Míriam R. García's Publications List

Positive Feedback in the AKT/mTOR pathway and its implications for growth signal progression in skeletal muscle cells: An analytical study

2012-01-18T18:08:51Z

F López-Caamal, M.R. García, R.H. Middleton, H.J Huber (2012) Journal of Theoretical Biology. Accepted :

A Robust Multi-Model Predictive Controller for Distributed Parameter Systems

2012-01-18T16:02:35Z

In this work a robust nonlinear model predictive controller for nonlinear convection-diffusion-reaction systems is presented. The controller makes use of a collection of reduced order approximations of the plant (models) reconstructed on-line by projection methods on POD (Proper Orthogonal Decomposition) basis functions. The model selection and model update step is based on a sufficient condi...

M R García, C Vilas, L O Santos, A A Alonso (2012) Journal of Process Control 22: 1 60-71

Optimal On-line Decision Making for Food Thermal Processes

2012-01-18T17:57:41Z

The thermal processing of packaged foods is intended to inactivate possible spores, microorganisms or enzymes present in the foodstuff which may have a negative impact on consumer’s health or product quality. To that purpose, the product is subject to a given time-temperature profile on a heating-cooling cycle so to attain a pre-specified degree of inactivation indicated by the so-called micr...

A. Arias-Mendez, E. Balsa-Canto, M.R. Garcia, J.I. Molina, C. Vilas, M Villafin, A. A. Alonso (2011) 11th International Congress on Engineering and Food , May 22-26, 2011. Athens (Greece)

2012-01-18T18:01:24Z

Computational approaches are significant in the analysis of events that are multi-factorial. Parkinson’s Disease (PD) is the cumulative result of system malfunctioning that leads to severe degeneration in the Substantia nigra (SN), a locus in the mid-brain. Traditional approaches tend to focus on isolated sub-components of the pathogenic pathways. However, such an approach may be inadequate to d...

F. Francis, M.R. Garcia, P. Wellstead, R.H. Middleton Calcium handling aspects of Parkinson’s Disease pathogenesis (2011) 10th International Congress on Alzheimer's & Parkinson's Diseases. March 9-13. Barcelona (Spain)

On-line estimation in a distributed parameter bioreactor: Application to the gluconic acid production

2012-01-18T17:26:22Z

This work presents a methodology which exploits the underlying biochemical structure of bioprocesses to estimate concentrations in aerobic fermenters from oxygen measurements. Although a number of estimators have been proposed over the years in the literature, the methodology proposed in this work is able to operate in transient conditions while does not require the knowledge of the growth kinetic...

M R García, C Vilas, E Balsa-Canto, V N Lyubenova, M N Ignatova and A A Alonso (2011) Computers & Chemical Engineering 35: 1 84-91

Deep Brain Stimulation may Reduce Tremor by Preferential Blockade of Slower Axons via Antidromic Activation

2012-01-18T17:56:12Z

Deep brain stimulation (DBS) has been used to ameliorate essential and Parkinsonian tremor. The detailed mechanism by which this tremor reduction is achieved remains unclear. We hypothesize that the mechanism is the reduction of time delays in the feedback paths of the motor control system. Stimulator induced antidromic activation of axonal pathways will preferentially block axons with longe...

M R García, M Verwoerd, B A Pearlmutter, P E Wellstead, R H Middleton (2011) Proceedings of the 49th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC . December, Orlando (US)

2012-01-18T15:26:20Z

MR García, M Verwoerd, PE Wellstead, RH Middleton, BA Pearlmutter The Slow Axon Blockade Hypothesis for Deep Brain Stimulation (2011) Neuroscience Ireland Annual Conference 2011 September Maynooth (Ireland)

Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons. Ion exchange dynamics at the pacemaking membrane.

2012-01-18T18:09:40Z

Cytosolic calcium ion levels are critical in sustaining neuronal activity. They have an intricate relationship with the neuronal energy systems, and Parkinson’s disease probably involves a dysfunctional energy system in the pacemaking neu-rons of the Substantia nigra. This chapter explores the association of repetitive firing pattern of these neurons and cytosolic calcium using a mathematical mo...

F. Francis, M.R García, R.H. Middleton. (2011) Systems Biology of Parkinson's Disease (Accepted)

AN ILL-FATED Substantia Nigra THROUGH THE SYSTEMS LOOKING GLASS An Energetic Overview

2012-01-18T15:29:02Z

The understanding of neurodegeneration of the Substantia nigra (SN), the hallmark of Parkinson's Disease (PD) is limited. The majority of studies conducted focus on isolated sub-components of the relevant pathogenic pathways. However, this isolated approach may be inadequate to describe the pathogenesis. A systems approach employing in-silico modelling facilitates the linking of diverse sub-compon...

F Francis, M R García, P Wellstead, R Middleton (2010) 2nd World Parkinson Congress. September 28-October 1. Glasgow (Scotland). Abstract in Movement Disorders Volume: 25 Pages: S624-S625

2012-01-18T15:35:05Z

In recent years, Markov processes have been widely used to describe opening probabilities of ion-channels. This approach can be readily combined with thermodynamics to obtain a model without employing abstract concepts such as in the commonly used Hodgkin-Huxley formalism. However in these Markov models, the number of important states is often am- biguous and overestimating this number creates...

F. Francis, M R García, O Mason, R Middleton A Mathematical Model for Voltage Gated Ion-channel Conduction (2010) The 11th International Conference on Systems Biology. October 11-14. Edinburgh (Scotland)

3rd International Workshop on Systems Biology (IWSB)

2010-08-20T15:00:08Z

(2010) August, 15-18. National University of Ireland, Maynooth

1st Symposium on Systems Approaches to Parkinson's Disease (SAPD)

2010-08-20T15:00:16Z

(2010) August, 18-19. National University of Ireland, Maynooth

2012-01-18T17:51:34Z

The degeneration of dopaminergic (DA) neurons in the Substantia Nigra pars compacta (SNc) is a hallmark of idiopathic Parkinson's disease (PD). However, resolving the degeneration mechanisms which target these neurons is not simple. For example, it is well known that DA neurons in the SNc deteriorate with age and are prone to die in PD, but there is no clear picture of what causes this or other re...

M. R. García A whole cell model of calcium homeostasis in dopaminergic substantia nigra neurons (2010) Invited speaker, 1st symposium on Systems Approaches to Parkinson's Disease . August, 18-19. Maynooth (Ireland)

2012-01-18T17:51:15Z

F. Francis, M.R. García, R.H. Middleton. Implications of Lewy Body formation in Parkinson's Disease (2010) 1st symposium on Systems Approaches to Parkinson's Disease . August, 18-19. Maynooth (Ireland) :

Dynamic Modeling and Simulation for Robust Control of Distributed Processes and Bio-processes

2012-01-18T15:42:01Z

A.A. Alonso, M.R. García, C. Vilas (2010) Process Systems Engineering Vol. 7: Process Modeling. Chapter 11 369-402

Dynamic model building using optimal identification strategies, with applications in bioprocess engineering

2012-01-18T15:42:30Z

E. Balsa-Canto, M.R. García, J.R. Banga (2010) Process Systems Engineering Vol. 7: Process Modeling. Chapter 13 441-468

Real Time Optimisation for thermal Processes

2012-01-18T18:02:44Z

This work presents the theoretical design and the experimental validation of a real time optimisation logic for distributed parameter systems. This logic consists of a hierarchy of two layers. The upper layer is responsible of obtaining the optimal control profile by a suitable combination of the control vector parameterisation approach with a hybrid globallocal optimiser and the use of reduced mo...

M.R. García, C. Vilas, E. Balsa-Canto, A.A. Alonso (2009) Proceedings of the European Control Conference 2009 - Budapest, Hungary 2039-2044

Neurofuzzy model based predictive control for thermal batch processes

2011-01-26T13:38:27Z

In many cases, it is difficult to derive a precise mathematical model, based on first principles, for a given process. Besides, the computation of the solution of models obtained through this methodology may require a large computational effort making them useless for real time tasks like control or optimization. Neurofuzzy modelling, which permits an easy way to derive successful models, is a goo...

J.M. Escaño, C. Bordóns, C. Vilas, M.R. García and A.A. Alonso (2009) Journal of Process Control 19: 9 1566-1575

Development of a library of components in EcosimPro for the operation of thermal processing plants

2012-01-18T15:44:17Z

In this work a library of operation units for the simulation, optimisation and control of thermal processes in the food industry is presented. Food processing plants are good examples of hybrid systems where continuous dynamics are coupled with discrete events. The library was developed in EcosimPro since it is able to efficiently handle hybrid systems. In addition, it includes a user friendly gra...

C Vilas, M R García, J R Banga, A A Alonso (2008) Revista Iberoamericana de Automática e Informática Industrial (RIAI) 5: 1 51-65

A Library of Software Components for the Operation of Thermal Food Processing Plants

2011-01-26T13:52:53Z

C Vilas, M R García, J R Banga, A A Alonso (2008) Proceedings of the Fourth International Symposium on Applications of Modeling as an Innovative Technology in the Agri-Food-Chain, Madrid, Spain, 9-11 June 2008.

Identification and Real Time Optimisation in the Food Processing and Biotechnology Industries

2012-01-18T15:52:44Z

Many of the processes in the food and biotechnology industries are operated in batch or semi-continuous modes thus being dynamic in nature. In addition some relevant state variables, or even manipulable variables (controls), depend not only on time but on position, i.e. distributed process systems (DPSs). This PhD work has been aimed at the development of real time optimisation (RTO) schem...

M R García (2008)

Intelligent Control Based on Reinforcement Learning for Batch Thermal Sterilization of Canned Foods

2012-01-18T15:49:21Z

S Siafie, C Vilas, M R García, F Tadeo, A A Alonso, E Martinez (2008) IFAC’08. 6-11 July. Seul (Korea)

Robust feed-back control of travelling waves in a class of reaction–diffusion distributed biological system

2011-01-26T13:40:57Z

Reaction-Difusion (RD) mechanisms can describe many biological phenomena such as neuron firing in the brain, the heartbeat, cellular organization activities or even biological disorders such as fibrillation. The FitzHugh-Nagumo (FHN) model is a particular case of RD systems. It is able to capture the key features of many biolog- ical processes and since it is relatively simple it has been wide...

C Vilas, M R García, J R Banga, A A Alonso (2008) Physica D : Nonlinear Phenomena 237,: 18 2353-2364

Indirect adaptive linearizing control of a class of bioprocesses - Estimator tuning procedure

2011-01-26T13:40:49Z

In the paper, a class of bioprocesses with fully unknown kinetics is considered. Indirect adaptive control algorithm where the process kinetics is presented as unknown time-varying parameter is derived. A general procedure for optimal tuning of kinetic estimator design parameters is proposed by stability analysis of the control scheme. Theoretical results are verified by simulations of the control...

M N Ignatova, V N Lyubenova, M R García, C Vilas, A A Alonso (2008) Journal of Process Control 18: 1 27-35

A nonlinear model predictive controller for the start-up of a open plate reactor

2011-02-06T17:54:17Z

A novel chemical reactor, the Open Plate Reactor, is being develop by Alfa Laval AB. It combine good mixing with high heat transfer capacity. In this reactor highly exothermic reactions can be produced using more concentrated reactants. A nonlinear model predictive control is proposed to maximize the reaction yield under hard input and state constraints. A reduced order model is proposed to decrea...

M Rodríguez, C de Prada, A A. Alonso, C Vilas and M R. García (2008) International Workshop on assesment and future directions of Nonlinear model predictive control. NMPC08. 5-9 September Pavia (Italy)

Real Time Optimization of the thermal processing of bioproducts in batch units

2011-01-26T13:52:27Z

M R García, C Vilas, A A Alonso, E Balsa-Canto (2008) Proceedings of the Fourth International Symposium on Applications of Modeling as an Innovative Technology in the Agri-Food-Chain, Madrid, Spain, 9-11 June 2008.

Deep Brain Stimulation in Parkinson’s disease Workshop. Hamilton Institute. National University of Ireland, Maynooth

2012-01-18T17:49:19Z

(2008)

2012-01-18T17:53:09Z

The electrical stimulation of the brain for the treatment of neuropsychiatric disorders has a long history that goes back to the early 1950s. Specifically it was first used for the treatment of tremor in Parkinsons Disease (PD) in 1968. However it was not until the work of Limousin and coauthors that deep brain stimulation (DBS) was commonly accepted as a therapeutic procedure for PD. Since th...

M R García, M Verwoerd and P Wellstead Deep Brain Stimulation in Parkinson disease: the de-synchronisation hypothesis (2008) The 2nd International Workshop on Systems Biology . August 17-20. Maynooth (Ireland)

Exponential observers for distributed tubular (bio)reactors

2012-01-18T17:40:07Z

The dissipative nature of spatially distributed process systems is exploited to develop efficient exponential state observers based on a low-dimensional dynamic representation of the original set of partial differential equations. The suggested approach combines standard observer design techniques for reactors, where the reaction rates are unknown with efficient model reduction methodologies b...

M R García, C Vilas, J R Banga, A A Alonso (2008) AIChE Journal 54: 11 2943 - 2956

Optimal field reconstruction of distributed process systems from partial measurements

2011-01-26T13:43:15Z

In this article, we develop a systematic approach for efficient field reconstruction in distributed process systems from a limited number of measurements. The approach generalizes previous methods for sensor placement so as to be able to handle field reconstruction problems in arbitrary spatial domains where complex nonlinear phenomena take place. Pattern formation in fluid dynamics or diffusion-r...

M R García, C Vilas, J R Banga, A A Alonso (2007) Industrial and Engineering Chemistry Research 46: 2 530-539

Contribution to the project "Proyecto Neuston. Experimento 1. Explorando la interfase"

2012-01-18T13:58:38Z

Neuston is the collective term for the organisms that float on the top of water or live right under the surface, in the interface between water and air. Taking this as a metaphor, the project explores the interface science-art, prompting a dialogue which involves scientific researchers and artistic and literary creators concerned with the sea and with Galicia’s marine scientific environment. ...

(2007) Neuston. Experimento 1. Explorando a interface. (Ed.) Pintado, J. Museo do Mar de Galicia, Vigo. 160 pp. ISBN: 978-84-936963-3-7. (1000 ejemplares editados).

Robust feed-back control of distributed chemical reaction systems

2011-01-26T13:43:22Z

There are many distributed processes in the chemical industry as it is the case of tubular reactors in which the parameters or the structure of the reaction terms are only a rough approximation of reality. In order to efficiently control this kind of systems, it is important to take into account this lack of detailed information (robustness). In this work, we make use of the classical theory on th...

C Vilas, M R García, J R Banga, A A Alonso (2007) Chemical Engineering Science 62: 11 2941-2957

Control Predictivo basado en Modelo Neuroborroso de un Autoclave Industrial

2012-01-18T15:50:57Z

J M Escaño, C Bordóns, M R García, C Vilas, A A Alonso (2007) XXVIII Jornadas de Automática. 5-7 September. Huelva (Spain) :

Stabilization of inhomogeneous patterns in a diffusion-reaction system under structural and parametric uncertainties

2011-01-26T13:43:29Z

Many phenomena such as neuron firing in the brain, the travelling waves which produce the heartbeat, arrythmia and fibrillation in the heart, catalytic reactions or cellular organization activities, among others, can be described by a unifying paradigm based on a class of nonlinear reaction-diffusion mechanisms. The FitzHugh-Nagumo (FHN) model is a simplified version of such class which is known t...

C Vilas, M R García, J R Banga, A A Alonso (2006) Journal of Theoretical Biology 241: 2 295-306

2012-01-18T15:13:53Z

M R García, C Vilas, J R Banga, A A Alonso Optimal Field Reconstruction of Distributed Process Systems from Partial Measurements (2006) 2006 AIChE Annual Meeting. 12-17 November. San Francisco (USA)

Diseño óptimo de experimentos para calibración de modelos : Aplicación al procesamiento térmico de alimentos en autoclave

2012-01-18T15:51:30Z

M R García, E Balsa-Canto, J R Banga, A A Alonso (2006) XXVII Jornadas de Automática. 6-9 September. Almería (Spain) :

Entorno eficiente de Simulación Dinámica para la Operación de Plantas de Procesamiento de Alimentos

2012-01-18T15:51:55Z

C Vilas, M R García, M Villafín, J R Banga, A A Alonso (2006) XXVII Jornadas de Automática. 6-9 September. Almería (Spain) :

Control of Travelling Waves in Reaction-Diffusion Biological Systems

2011-01-26T14:03:02Z

C Vilas, M R García, J R Banga, A A Alonso (2006) 5º MathMod. 8-10 Februry. Vienna (Austria)

Adaptive Linearizing Control of Gluconic Acid Fermentation by Aspergillus Niger

2012-01-18T17:15:27Z

M Ignatova, V Lyubenova, C Vilas, M R García (2006) 2nd International BioInfo’2006 Workshop on Computational Intelligence in Bioinformatics. 5 October. Sophia (Bulgaria) :

2012-01-18T15:14:08Z

M R García, C Vilas, L O Santos, A A Alonso A Robust and Stabilizing Multi-Model Predictive Control Approach to Command the Operation of Distributed Process Systems (2006) 2006 AIChE Annual Meeting. 12-17 November. San Francisco (USA)

Robust Stabilization of Inhomogeneous Patterns in a Reaction-Diffusion Biological System

2012-01-18T15:44:40Z

C Vilas, M R García, J R Banga, A A Alonso (2006) Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses 93-100

An Eficient Real-Time Dynamic Optimization Architecture for the Control of Non-Isothermal Tubular Reactors

2011-01-26T14:04:53Z

In this work we present the development of an efficient model-based real time dynamic optimization (DO) architecture for the control of distributed parameter systems (DPS). The approach takes advantage of the dissipative nature of this class of systems to obtain reduced order models (ROM) which are then used by the optimization modules to compute in real time the optimal operation policy. The ...

M R García, E Balsa-Canto, C Vilas, J R Banga, A A Alonso (2005) Computer aided Chemical Engineering. Volume 20 1333-1338

Model for control of gluconic acid fermentation by Aspergillus Niger and its application for observers design

2011-08-22T13:42:04Z

MN Ignatova, VN Lyubenova, CV Fernández, MR García, AA Alonso. (2005) Agricultural and Food Sciences, Processes and Technologies. Sibiu

State reconstruction in spatially distributed BioProcess systems using reduced order models : Application to the gluconic acid production

2011-02-06T18:05:51Z

In this work, the dissipative nature of spatially distributed bioprocess systems is exploited to develop efficient state observers based on a low dimensional dynamic representation of the original set of partial differential equations. The approach we suggest combines standard observer design techniques for bioreactors with efficient model reduction methodologies based on projection of the origina...

M R García, C Vilas, J R Banga, V N Lyubenova, M N Ignatova, A A Alonso (2005) Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC. December 12-15. Seville (Spain) 6256-6261

2012-01-18T15:14:27Z

C Vilas, M R García, J R Banga, A A Alonso Robust control of inhomogeneous patterns in reaction-diffusion systems using reduced order models (2005) AIChE Annual Meeting, Conference Proceedings. September 30-October 4. Cincinnati (USA) : 6104-6105

An efficient real-time dynamic optimization architecture for the control of non-isothermal tubular reactors

2011-02-06T18:05:01Z

M R García, E Balsa-Canto, C Vilas, J R Banga, A A Alonso (2005) EUROPEAN SYMPOSIUM ON COMPUTER-AIDED PROCESS ENGINEERING-15. May 29-June 5. Barcelona (Spain) : 1333-1338

An Efficient Dynamic Simulation Environment for the Operation of Food Processing Plants

2011-08-22T13:40:18Z

C Vilas, MR García, M Villafín, JR Banga, AA Alonso (2004) International Congress on Engineering and Food (ICEF9), Montpellier.

On systematic model reduction techniques for dynamic optimization and robust control of distributed process systems

2011-02-06T18:06:42Z

C Vilas, M R García, M R Fernandez, E Balsa-Canto, J R Banga, A A Alonso (2004) EUROPEAN SYMPOSIUM ON COMPUTER-AIDED PROCESS ENGINEERING - 14. May 16-19. Lisbon (Portugal) : 841-846

Observer Design and Parameter Estimation Tools for Food Processing Plants

2011-08-22T13:39:08Z

MR García, C Vilas, JR Banga, AA Alonso (2004) International Congress on Engineering and Food (ICEF9), Montpellier.

On systematic model reduction techniques for dynamic optimization and robust control of distributed process systems

2011-01-26T14:07:12Z

C Vilas, M R García, M R Fernandez, E Balsa-Canto, J R Banga, A A Alonso (2004) Computer aided Chemical Engineering. Volume 18 : 841-846

Editor and writer of the supplement "Mar y Pesca" in the Newspaper Faro de Vigo

2012-01-18T13:58:23Z

(2003)

2009-12-15T11:34:55Z

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