http://publicationslist.org/data/mahmud.khan/atom.xml Mahmud Tareq Hassan Khanhttp://publicationslist.org/mahmud.khan$basepathfavicon.icoRecent additions to Mahmud Tareq Hassan Khan's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-03-20T14:03:09Z http://publicationslist.org/mahmud.khan/refid6 2008-03-20T13:57:55Z

A set of novel atom-based molecular fingerprints is proposed based on a bilinear map similar to that defined in linear algebra. These molecular descriptors (MDs) are proposed as a new means of molecular parametrization easily calculated from 2D molecular information. The nonstochastic and stochastic molecular indices match molecular structure provided by molecular topology by using the kth nonstoc...<br/><br/> Marrero-Ponce, Khan, Casañola Martín, Ather, Sultankhodzhaev, Torrens, Rotondo (2007) <i>ChemMedChem</i> <i></i> <i></i> 2: 4 449-478<br/>

http://publicationslist.org/mahmud.khan/refid7 2008-03-20T13:57:55Z

In this paper, we present a new set of bond-level TOMOCOMD-CARDD molecular descriptors (MDs), the bond-based bilinear indices, based on a bilinear map similar to those defined in linear algebra. These novel MDs are used here in Quantitative Structure-Activity Relationship (QSAR) studies of tyrosinase inhibitors, for finding functions that discriminate between the tyrosinase inhibitor compounds and...<br/><br/>Yovani Marrero-Ponce, Mahmud Tareq Hassan Khan, Gerardo M Casañola-Martín, Arjumand Ather, Mukhlis N Sultankhodzhaev, Ramón García-Domenech, Francisco Torrens, Richard Rotondo (2007) <i>J Comput Aided Mol Des</i> <i></i> <i></i> 21: 4 167-188<br/>

http://publicationslist.org/mahmud.khan/refid9 2008-03-20T13:57:55Z

A new set of bond-level molecular descriptors (bond-based linear indices) are used here in QSAR (quantitative structure-activity relationship) studies of tyrosinase inhibitors, for finding functions that discriminate between the tyrosinase inhibitor compounds and inactive ones. A database of 246 compounds was collected for this study; all organic chemicals were reported as tyrosinase inhibitors; t...<br/><br/>Gerardo M Casañola-Martín, Yovani Marrero-Ponce, Mahmud Tareq Hassan Khan, Arjumand Ather, Sadia Sultan, Francisco Torrens, Richard Rotondo (2007) <i>Bioorg Med Chem</i> <i></i> <i></i> 15: 3 1483-1503<br/>

http://publicationslist.org/mahmud.khan/refid4 2008-03-20T13:57:55Z

The ethanolic extract from Hemidesmus indicus (Linn) (Apocynaceae) (Hie) was studied for its otoprotective effects in ex vivo rat organotypic model of gentamicin (GM) toxicity. In organ of Corti organotypic cultures (OC), GM can induce a fast dose-dependent apoptosis of hair cells (HC), both external and internal. We found that, after coadministration of GM and Hie to organotypic cultures, the ext...<br/><br/>Maurizio Previati, Elisa Corbacella, Laura Astolfi, Marco Catozzi, Mahmud Tareq Hassan Khan, Ilaria Lampronti, Roberto Gambari, Silvano Capitani, Alessandro Martini (2007) <i>J Chem Neuroanat</i> <i></i> <i></i> 34: 3-4 128-133<br/>

http://publicationslist.org/mahmud.khan/refid5 2008-03-20T13:57:55Z

QSAR (quantitative structure-activity relationship) studies of tyrosinase inhibitors employing Dragon descriptors and linear discriminant analysis (LDA) are presented here. A data set of 653 compounds, 245 with tyrosinase inhibitory activity and 408 having other clinical uses were used. The active data set was processed by k-means cluster analysis in order to design training and prediction series....<br/><br/>Gerardo M Casañola-Martín, Yovani Marrero-Ponce, Mahmud Tareq Hassan Khan, Arjumand Ather, Khalid M Khan, Francisco Torrens, Richard Rotondo (2007) <i>Eur J Med Chem</i> <i></i> <i></i> 42: 11-12 1370-1381<br/>

http://publicationslist.org/mahmud.khan/refid1 2008-03-20T13:57:55Z

Chemical breakthrough generates large numbers of prospective drug molecules; the use of ADMET (absorption, distribution, metabolism, excretion and toxicity) properties is flattering progressively more imperative in the drug discovery, assortment, development and promotion processes. Due to the inauspicious ADMET properties a huge amount of molecules in the development stage got failure. In the pas...<br/><br/>Mahmud Tareq Hassan Khan, Ingebrigt Sylte (2007) <i>Curr Drug Discov Technol</i> <i></i> <i></i> 4: 3 141-149<br/>

http://publicationslist.org/mahmud.khan/refid2 2008-03-20T13:57:55Z

Identification of phenolic compounds and their derivatives interfering the several steps of the viral life cycle of the human immunodeficiency virus type 1 (HIV-1) is focused for the development of novel molecules for the treatment of AIDS. Several phenolic compounds isolated and characterized from natural sources have been studied in detail and found to exhibit inhibitory effects against differen...<br/><br/> Hassan Khan, Ather (2007) <i>Biotechnol Annu Rev</i> <i></i> <i></i> 13C: 223-264<br/>

http://publicationslist.org/mahmud.khan/refid3 2008-03-20T13:57:55Z

During the course of screening of medicinal plants of Pakistan for the isolation and structure elucidation of bioactive natural products, it was found that the methanol extract of the Rhododendron collettianum showed analgesic and spasmolytic activities. The methanol extract was then extracted with chloroform. Nine pentacyclic triterpenes were isolated from the chloroform extract and their structu...<br/><br/>Farman Ullah, Hidayat Hussain, Javid Hussain, Ishfaq A Bukhari, Mahmud Tareq Hassan Khan, M Iqbal Choudhary, Anwar H Gilani, Viqar Uddin Ahmad (2007) <i>Phytother Res</i> <i></i> <i></i> 21: 11 1076-1081<br/>

http://publicationslist.org/mahmud.khan/refid11 2008-03-20T13:57:55Z

In the present paper, tyrosinase inhibition studies and structure-activity relationship of eight cycloartane glycosides and one cucurbitane glycoside and its genin, which were isolated from Astragalus (Leguminoseae) and Bryonia (Cucurbitaceae) plants, have been discussed. The activities are compared with two reference tyrosinase inhibitors, kojic acid and l-mimosine. These studies and the SAR show...<br/><br/>Mahmud Tareq Hassan Khan, M Iqbal Choudhary, Atta-ur-Rahman, Reyhan P Mamedova, Manzura A Agzamova, Mukhlis N Sultankhodzhaev, Mahamed I Isaev (2006) <i>Bioorg Med Chem</i> <i></i> <i></i> 14: 17 6085-6088<br/>

http://publicationslist.org/mahmud.khan/refid10 2008-03-20T13:57:55Z

The tyrosinase inhibitory potential of seventeen synthesized oxazolone derivatives has been evaluated and their structure-activity relationships developed in the present work. All the synthesized derivatives, 3-19, demonstrated excellent in vitro tyrosinase inhibitory properties having IC50 values in the range of 1.23+/-0.37-17.73+/-2.69 microM, whereas standard inhibitors l-mimosine and kojic aci...<br/><br/>Khalid Mohammed Khan, Uzma Rasool Mughal, Mahmud Tareq Hassan Khan, Zia-Ullah, Shahnaz Perveen, Muhammad Iqbal Choudhary (2006) <i>Bioorg Med Chem</i> <i></i> <i></i> 14: 17 6027-6033<br/>

http://publicationslist.org/mahmud.khan/refid14 2008-03-20T13:57:55Z

New tyrosinase inhibitory cycloartane triterpenoids have been discovered from the methanol extract of the whole plant of Amberboa ramosa (Roxb.) Jafri, which is a member from the Compositae family. Utilizing the conventional spectroscopic techniques, including 1D and 2D NMR analysis, and also by comparing the experimental with literature data, the isolated compounds proved to be cycloartane type t...<br/><br/>Mahmud Tareq Hassan Khan, Sher Bahadar Khan, Arjumand Ather (2006) <i>Bioorg Med Chem</i> <i></i> <i></i> 14: 4 938-943<br/>

http://publicationslist.org/mahmud.khan/refid13 2008-03-20T13:57:55Z

In the present report, the use of the atom-based linear indices for finding functions that discriminate between the tyrosinase inhibitor compounds and inactive ones is presented. In this sense, discriminant models were applied and globally good classifications of 93.51% and 92.46% were observed for non-stochastic and stochastic linear indices best models, respectively, in the training set. The ext...<br/><br/>Gerardo M Casañola-Martín, Mahmud Tareq Hassan Khan, Yovani Marrero-Ponce, Arjumand Ather, Mukhlis N Sultankhodzhaev, Francisco Torrens (2006) <i>Bioorg Med Chem Lett</i> <i></i> <i></i> 16: 2 324-330<br/>

http://publicationslist.org/mahmud.khan/refid15 2008-03-20T13:57:55Z

Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC(50)=2.06 microM), 11 (IC(50)=2.09 microM), 15 (IC(50)=2.61 microM), and 27 (IC(50)=3.19 microM) were found to be the most active compounds of the series, even better than both standards kojic acid (IC(50)=16.67 microM) and L-mimosine (IC(50)=3.68 m...<br/><br/>Khalid Mohammed Khan, Ghulam Murtaza Maharvi, Mahmud Tareq Hassan Khan, Ahson Jabbar Shaikh, Shahnaz Perveen, Saeedan Begum, Mohammad Iqbal Choudhary (2006) <i>Bioorg Med Chem</i> <i></i> <i></i> 14: 2 344-351<br/>

http://publicationslist.org/mahmud.khan/refid20 2008-03-20T13:57:55Z

In the present article, tyrosinase inhibition studies on fifteen diterpenoid alkaloids, with lycoctonine skeleton, and their semisynthetic derivatives 1-15 and six napelline-type compounds 16-21 are discussed. Their structure-activity relationship for tyrosinase inhibition is also discussed. These activities were compared with two referenced tyrosinase inhibitors, kojic acid and L-mimosine. The st...<br/><br/>Mukhlis N Sultankhodzhaev, Mahmud Tareq Hassan Khan, Mahera Moin, M Iqbal Choudhary, Atta-ur-Rahman (2005) <i>Nat Prod Res</i> <i></i> <i></i> 19: 5 517-522<br/>

http://publicationslist.org/mahmud.khan/refid21 2008-03-20T13:57:55Z

Here the tyrosinase inhibition studies of library of 2,5-disubstituted-1,3,4-oxadiazoles have been reported and their structure-activity relationship (SAR) also have been discussed. The library of the oxadiazoles was synthesized under the microwave irradiation and was structures of these were characterized by different spectral techniques. From this study it could be concluded that for a better in...<br/><br/>Mahmud Tareq Hassan Khan, Muhammad Iqbal Choudhary, Khalid Mohammed Khan, Mubeen Rani, Atta-ur-Rahman (2005) <i>Bioorg Med Chem</i> <i></i> <i></i> 13: 10 3385-3395<br/>

http://publicationslist.org/mahmud.khan/refid19 2008-03-20T13:57:55Z

Vanadium complexes are known to possess potent insulin-mimetic effects, high affinity for several enzymes and anticancer activity, which deserve increasing attention for application to biomedical sciences. Different vanadium complexes have been found to be more effective than the simple vanadium-(IV) and -(V) salts in experiments performed both in vitro and in vivo. Application of polyoxometalates...<br/><br/>Ilaria Lampronti, Nicoletta Bianchi, Monica Borgatti, Enrica Fabbri, Leonardo Vizziello, Mahmud Tareq Hassan Khan, Arjumand Ather, Dan Brezena, Mohammad Mahroof Tahir, Roberto Gambari (2005) <i>Oncol Rep</i> <i></i> <i></i> 14: 1 9-15<br/>

http://publicationslist.org/mahmud.khan/refid22 2008-03-20T13:57:55Z

The present study evaluated the anticancer potential of 11 plants used in Bangladeshi folk medicine. The extracts were tested for cytotoxicity using the brine shrimp lethality assay, sea urchin eggs assay, hemolysis assay and MTT assay using tumor cell lines. The extract of Oroxylum indicum showed the highest toxicity on all tumor cell lines tested, with an IC(50) of 19.6 microg/ml for CEM, 14.2 m...<br/><br/>Letícia Veras Costa-Lotufo, Mahmud Tareq Hassan Khan, Arjumand Ather, Diego Veras Wilke, Paula Christine Jimenez, Cláudia Pessoa, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes (2005) <i>J Ethnopharmacol</i> <i></i> <i></i> 99: 1 21-30<br/>

http://publicationslist.org/mahmud.khan/refid18 2008-03-20T13:57:55Z

Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection. Therefore, the discovery of novel anti-HSV drugs deserves great efforts. In this paper, we review anti-HSV substances from natural sources, including both extracts and pure compounds from herbal ...<br/><br/>Mahmud Tareq Hassan Khan, Arjumand Ather, Kenneth D Thompson, Roberto Gambari (2005) <i>Antiviral Res</i> <i></i> <i></i> 67: 2 107-119<br/>

http://publicationslist.org/mahmud.khan/refid17 2008-03-20T13:57:55Z

The microbial transformation of the 17alpha-ethynyl-17beta-hydroxyandrost-4-en-3-one (1) (ethisterone) and 17alpha-ethyl-17beta-hydroxyandrost-4-en-3-one (2) by the fungi Cephalosporium aphidicola and Cunninghamella elegans were investigated. Incubation of compound 1 with C. aphidicola afforded oxidized derivative, 17alpha-ethynyl-17beta-hydroxyandrosta-1,4-dien-3-one (3), while with C. elegans af...<br/><br/>M Iqbal Choudhary, Sadia Sultan, Mahmud Tareq Hassan Khan, Atta-Ur- Rahman (2005) <i>Steroids</i> <i></i> <i></i> 70: 12 798-802<br/>

http://publicationslist.org/mahmud.khan/refid16 2008-03-20T13:57:55Z

The aim of the present study was to determine whether the expression of the estrogen receptor alpha (ERalpha) gene may be a possible target for compounds present in plant extracts from Aegle marmelos and Emblica officinalis, used in traditional Asian medicine in the treatment of tissue inflammation and cancer. To this aim, we evaluated the potential of the selected plant extracts to affect prolife...<br/><br/>Elizabeth Lambertini, Ilaria Lampronti, Letizia Penolazzi, Mahmud Tareq Hassan Khan, Arjumand Ather, Gianluca Giorgi, Roberto Gambari, Roberta Piva (2005) <i>Oncol Res</i> <i></i> <i></i> 15: 2 69-79<br/>

http://publicationslist.org/mahmud.khan/refid8 2008-03-20T13:57:55Z

The microwave-assisted synthesis and characterization of the ten new sildenafil (Viagra; 1) analogues 6-15 are described. A detailed structure-activity-relationship (SAR) study revealed that compounds 10 (= 4-ethoxy-N-hydroxy-3-(7-methoxy-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide) and 12 (= S-(2-hydroxyethyl) 4-ethoxy-3-(7-methoxy-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyr...<br/><br/>Khalid Mohammed Khan, Ghulam Murtaza Maharvi, Shahnaz Perveen, Mahmud Tareq Hassan Khan, Raid J Abdel-Jalil, Syed Tasadaque Ali Shah, Miriam Fecker, Muhammad Iqbal Choudhary, Wolfgang Voelter (2005) <i>Chem Biodivers</i> <i></i> <i></i> 2: 4 470-476<br/>

http://publicationslist.org/mahmud.khan/refid24 2008-03-20T13:57:55Z

In this study we determined the activity of extracts from Bangladeshi medicinal plants (Emblica officinalis, Aegle marmelos, Vernonia anthelmintica, Oroxylum indicum, Argemone mexicana) on human breast tumor cell lines. Extracts from E. officinalis and O. indicum displayed anti-proliferative activity on MCF7 and MDA-MB-231 breast cancer cell lines, while extracts from A. mexicana were active on MC...<br/><br/>Elisabetta Lambertini, Roberta Piva, Mahmud Tareq Hassan Khan, Ilaria Lampronti, Nicoletta Bianchi, Monica Borgatti, Roberto Gambari (2004) <i>Int J Oncol</i> <i></i> <i></i> 24: 2 419-423<br/>

http://publicationslist.org/mahmud.khan/refid23 2008-03-20T13:57:55Z

A new coumarinolignoid 8'-epi-cleomiscosin A (1) together with the new glycoside 8-O-beta-D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also...<br/><br/>Viqar Uddin Ahmad, Farman Ullah, Javid Hussain, Umar Farooq, Muhammad Zubair, Mahmud Tareq Hassan Khan, Muhammad Iqbal Choudhary (2004) <i>Chem Pharm Bull (Tokyo)</i> <i></i> <i></i> 52: 12 1458-1461<br/>

http://publicationslist.org/mahmud.khan/refid12 2008-03-20T13:57:55Z

The bioactivity studies of the individual ingredients of Dashamularishta--a classical Ayurvedic preparation were done with the aqueous extracts of the individual ingredients. The Aegle marmelos Correa. exhibited severe toxicity to the brine shrimp (BST) nauplii, wheat rootlet growth (WRG) inhibition bioassay and lettuce seed germination (LSG) bioassay. It exhibited no inhibition to the growth of P...<br/><br/>Shaila Jabbar, Mahmud Tareq Hassan Khan, M Shahabuddin K Choudhuri, Bijon K Sil (2004) <i>Pak J Pharm Sci</i> <i></i> <i></i> 17: 1 9-17<br/>

http://publicationslist.org/mahmud.khan/refid25 2008-03-20T13:57:55Z

In this study we compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-lymphoid Jurkat, erythroleukemic HEL cell lines. Extracts from Emblica officinalis were the most active in inhibiting in vitro cell proliferation, after comparison to those from Terminalia arjuna, Aphanamixis poly...<br/><br/>Mahmud Tareq Hassan Khan, Ilaria Lampronti, Dino Martello, Nicoletta Bianchi, Shaila Jabbar, Mohammad Shahabuddin Kabir Choudhuri, Bidduyt Kanti Datta, Roberto Gambari (2002) <i>Int J Oncol</i> <i></i> <i></i> 21: 1 187-192<br/>