http://publicationslist.org/data/martin.welin/atom.xml Martin Welinhttp://publicationslist.org/martin.welin$basepathfavicon.icoRecent additions to Martin Welin's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-11-09T11:43:34Z http://publicationslist.org/martin.welin/refid10 2010-05-25T19:09:14Z

Interactions are the foundation of life at the molecular level. In the plethora of activities in the cell, the evolution of enzyme specificity requires the balancing of appropriate substrate affinity with a negative selection, in order to minimize interactions with other potential substrates in the cell. To understand the structural basis for enzyme specificity, the comparison of structural and bi...<br/><br/>Martin Welin, Pär Nordlund (2010) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 396: 1 157-163<br/>

http://publicationslist.org/martin.welin/refid11 2010-09-02T20:23:57Z

Human purine de novo synthesis pathway contains several multi-functional enzymes, one of which, tri-functional GART, contains three enzymatic activities in a single polypeptide chain. We have solved structures of two domains bearing separate catalytic functions: glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase. Structures are compared with those of homologous enzy...<br/><br/>Martin Welin, Jörg Günter Grossmann, Susanne Flodin, Tomas Nyman, Pål Stenmark, Lionel Trésaugues, Tetyana Kotenyova, Ida Johansson, Pär Nordlund, Lari Lehtiö (2010) <i>Nucleic Acids Res</i> <i></i> <i></i> : <br/>

http://publicationslist.org/martin.welin/refid12 2010-10-21T11:38:16Z

The human SnoN is an oncoprotein that interacts with several transcription-regulatory proteins such as the histone-deacetylase, N-CoR containing co-repressor complex and Smad proteins. This study presents the crystal structure of the Dachshund homology domain of human SnoN. The structure reveals a groove composed of conserved residues with characteristic properties of a protein-interaction surface...<br/><br/>Tomas Nyman, Lionel Trésaugues, Martin Welin, Lari Lehtiö, Susanne Flodin, Camilla Persson, Ida Johansson, Martin Hammarström, Pär Nordlund (2010) <i>PLoS One</i> <i></i> <i></i> 5: 9 <br/>

http://publicationslist.org/martin.welin/refid13 2010-11-09T11:41:45Z

Human hypoxanthine-guanine phosphoribosyltransferase (HPRT) (EC 2.4.2.8) catalyzes the conversion of hypoxanthine and guanine to their respective nucleoside monophosphates. Human HPRT deficiency as a result of genetic mutations is linked to both Lesch-Nyhan disease and gout. In the present study, we have characterized phosphoribosyltransferase domain containing protein 1 (PRTFDC1), a human HPRT ...<br/><br/>Martin Welin, Louise Egeblad, Andreas Johansson, Pål Stenmark, Liya Wang, Susanne Flodin, Tomas Nyman, Lionel Trésaugues, Tetyana Kotenyova, Ida Johansson, Staffan Eriksson, Hans Eklund, Pär Nordlund (2010) <i>FEBS J</i> <i></i> <i></i> : <br/>

http://publicationslist.org/martin.welin/refid1 2010-04-28T12:37:01Z

The inhibitor of apoptosis (IAP) family of proteins contains key modulators of apoptosis and inflammation that interact with caspases through baculovirus IAP-repeat (BIR) domains. Overexpression of IAP proteins frequently occurs in cancer cells, thus counteracting the activated apoptotic program. The IAP proteins have therefore emerged as promising targets for cancer therapy. In this work, X-ray c...<br/><br/>Maria Dolores Herman, Martin Moche, Susanne Flodin, Martin Welin, Lionel Trésaugues, Ida Johansson, Martina Nilsson, Pär Nordlund, Tomas Nyman (2009) <i>Acta Crystallogr Sect F Struct Biol Cryst Commun</i> <i></i> <i></i> 65: Pt 11 1091-1096<br/>

http://publicationslist.org/martin.welin/refid2 2010-04-28T12:37:01Z

Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide c...<br/><br/>Maria Dolores Herman, Tomas Nyman, Martin Welin, Lari Lehtiö, Susanne Flodin, Lionel Trésaugues, Tetyana Kotenyova, Alex Flores, Pär Nordlund (2008) <i>FEBS Lett</i> <i></i> <i></i> 582: 25-26 3590-3594<br/>

http://publicationslist.org/martin.welin/refid3 2010-04-28T12:37:01Z

Lionel Trésaugues, Pål Stenmark, Herwig Schüler, Susanne Flodin, Martin Welin, Tomas Nyman, Martin Hammarström, Martin Moche, Susanne Gräslund, Pär Nordlund (2008) <i>Proteins</i> <i></i> <i></i> 73: 4 1047-1052<br/>

http://publicationslist.org/martin.welin/refid4 2010-04-28T12:37:01Z

The crystal structure of uridine monophosphate kinase (UMP kinase, UMPK) from the opportunistic pathogen Ureaplasma parvum was determined and showed similar three-dimensional fold as other bacterial and archaeal UMPKs that all belong to the amino acid kinase family. Recombinant UpUMPK exhibited Michaelis-Menten kinetics with UMP, with K(m) and V(max) values of 214 +/- 4 microm and 262 +/- 24 micro...<br/><br/>Louise Egeblad-Welin, Martin Welin, Liya Wang, Staffan Eriksson (2007) <i>FEBS J</i> <i></i> <i></i> 274: 24 6403-6414<br/>

http://publicationslist.org/martin.welin/refid6 2010-04-28T12:37:01Z

Deoxyribonucleoside kinases (dNKs) catalyze the transfer of a phosphoryl group from ATP to a deoxyribonucleoside (dN), a key step in DNA precursor synthesis. Recently structural information concerning dNKs has been obtained, but no structure of a bacterial dCK/dGK enzyme is known. Here we report the structure of such an enzyme, represented by deoxyadenosine kinase from Mycoplasma mycoides subsp. m...<br/><br/>Martin Welin, Liya Wang, Staffan Eriksson, Hans Eklund (2007) <i>J Mol Biol</i> <i></i> <i></i> 366: 5 1615-1623<br/>

http://publicationslist.org/martin.welin/refid5 2010-04-28T12:37:01Z

We tested the general applicability of in situ proteolysis to form protein crystals suitable for structure determination by adding a protease (chymotrypsin or trypsin) digestion step to crystallization trials of 55 bacterial and 14 human proteins that had proven recalcitrant to our best efforts at crystallization or structure determination. This is a work in progress; so far we determined structur...<br/><br/>Aiping Dong, Xiaohui Xu, Aled M Edwards, Changsoo Chang, Maksymilian Chruszcz, Marianne Cuff, Marcin Cymborowski, Rosa Di Leo, Olga Egorova, Elena Evdokimova, Ekaterina Filippova, Jun Gu, Jennifer Guthrie, Alexandr Ignatchenko, Andrzej Joachimiak, Natalie Klostermann, Youngchang Kim, Yuri Korniyenko, Wladek Minor, Qiuni Que, Alexei Savchenko, Tatiana Skarina, Kemin Tan, Alexander Yakunin, Adelinda Yee, Veronica Yim, Rongguang Zhang, Hong Zheng, Masato Akutsu, Cheryl Arrowsmith, George V Avvakumov, Alexey Bochkarev, Lars-Göran Dahlgren, Sirano Dhe-Paganon, Slav Dimov, Ludmila Dombrovski, Patrick Finerty, Susanne Flodin, Alex Flores, Susanne Gräslund, Martin Hammerström, Maria Dolores Herman, Bum-Soo Hong, Raymond Hui, Ida Johansson, Yongson Liu, Martina Nilsson, Lyudmila Nedyalkova, Pär Nordlund, Tomas Nyman, Jinrong Min, Hui Ouyang, Hee-won Park, Chao Qi, Wael Rabeh, Limin Shen, Yang Shen, Deepthi Sukumard, Wolfram Tempel, Yufeng Tong, Lionel Tresagues, Masoud Vedadi, John R Walker, Johan Weigelt, Martin Welin, Hong Wu, Ting Xiao, Hong Zeng, Haizhong Zhu (2007) <i>Nat Methods</i> <i></i> <i></i> 4: 12 1019-1021<br/>

http://publicationslist.org/martin.welin/refid7 2010-04-28T12:37:01Z

The Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) double mutant N45D/N64D was identified during a previous directed evolution study. This mutant enzyme had a decreased activity towards the natural substrates and decreased feedback inhibition with dTTP, whereas the activity with 3'-modified nucleoside analogs like 3'-azidothymidine (AZT) was nearly unchanged. Here, we identify the mut...<br/><br/>Martin Welin, Tine Skovgaard, Wolfgang Knecht, Chunying Zhu, Dvora Berenstein, Birgitte Munch-Petersen, Jure Piskur, Hans Eklund (2005) <i>FEBS J</i> <i></i> <i></i> 272: 14 3733-3742<br/>

http://publicationslist.org/martin.welin/refid8 2010-04-28T12:37:01Z

Cytosolic thymidine kinase 1, TK1, is a well known cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs such as 3'-azido-3'-deoxythymidine (AZT). We have now determined the structures of the TK1 family, the human and Ureaplasma urealyticum enzymes, in complex with the feedback inhibitor dTTP. The TK1s have a tetrameric structu...<br/><br/>Martin Welin, Urszula Kosinska, Nils-Egil Mikkelsen, Cecilia Carnrot, Chunying Zhu, Liya Wang, Staffan Eriksson, Birgitte Munch-Petersen, Hans Eklund (2004) <i>Proc Natl Acad Sci U S A</i> <i></i> <i></i> 101: 52 17970-17975<br/>

http://publicationslist.org/martin.welin/refid9 2010-04-28T12:37:01Z

BACKGROUND: The bacterium Helicobacter pylori is associated with a number of gastrointestinal diseases, such as gastric ulcer, duodenal ulcer and gastric cancer. Several histological changes may be observed during the course of infection; some may influence the progression towards cancer. The aim of this study was to build a statistical model to discover direct interactions between H. pylori and d...<br/><br/>Martin Welin, Noél M A Holmgren, Patric Nilsson, Helena Enroth (2003) <i>Helicobacter</i> <i></i> <i></i> 8: 1 72-78<br/>