http://publicationslist.org/data/massimo.cossu/atom.xml massimo cossuhttp://publicationslist.org/massimo.cossu$basepathfavicon.icoRecent additions to massimo cossu's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-06-30T09:59:58Z http://publicationslist.org/massimo.cossu/refid56 2008-06-30T09:59:34Z

PURPOSE: To retrospectively analyze the results on seizures of surgery in children with drug-resistant focal epilepsy. To identify the factors predicting seizure control among several presurgical, surgical, and postsurgical variables. METHODS: One hundred thirteen patients (67 male, 46 female), younger than 16 years, operated on from 1996 to 2004 and followed-up for at least 2 years were identifie...<br/><br/>Massimo Cossu, Giorgio Lo Russo, Stefano Francione, Roberto Mai, Lino Nobili, Ivana Sartori, Laura Tassi, Alberto Citterio, Nadia Colombo, Manuela Bramerio, Carlo Galli, Laura Castana, Francesco Cardinale (2008) <i>Epilepsia</i> 49: 1 65-72<br/>

http://publicationslist.org/massimo.cossu/refid2 2008-06-30T09:51:32Z

PURPOSE: We recently demonstrated that in nocturnal frontal lobe epilepsy (NFLE) highly stereotyped minor motor events (MMEs, in the form of short-lasting stereotyped movements involving the limbs, the axial musculature, and/or the head), could occur in either the presence or absence of an epileptiform discharge (ED). In lack of a systematic analysis, both MMEs and EDs were frequently observed to ...<br/><br/>Michele Terzaghi, Ivana Sartori, Roberto Mai, Laura Tassi, Stefano Francione, Francesco Cardinale, Laura Castana, Massimo Cossu, Giorgio LoRusso, Raffaele Manni, Lino Nobili (2008) <i>Epilepsia</i> <i></i> <i></i> 49: 4 670-676<br/>

http://publicationslist.org/massimo.cossu/refid1 2008-06-30T09:51:32Z

In the stereo-electro-encephalography (SEEG) methodology developed by Talairach and Bancaud in Sainte-Anne Hospital in Paris, France, the objective of placing depth electrode recordings in presurgical evaluation is to study the spatial and temporal organization of a seizure. This defines for each patient the cortical onset zone, the propagation pattern of the seizure, and the possible involvement ...<br/><br/> Cossu, Chabardès, Hoffmann, Lo Russo (2008) <i>Neurochirurgie</i> <i></i> <i></i> 54: 3 367-373<br/>

http://publicationslist.org/massimo.cossu/refid5 2008-06-30T09:51:32Z

PURPOSE: Nocturnal frontal lobe epilepsy (NFLE) is characterized by a wide spectrum of sleep-related motor manifestations of increasing complexity, ranging from major episodes to brief motor events (minor motor events, MMEs). NFLE patients may exhibit a large quantity of MMEs in the form of short-lasting stereotyped movements. Whereas major episodes are considered epileptiform manifestations, it r...<br/><br/>Michele Terzaghi, Ivana Sartori, Roberto Mai, Laura Tassi, Stefano Francione, Francesco Cardinale, Laura Castana, Massimo Cossu, Giorgio LoRusso, Raffaele Manni, Lino Nobili (2007) <i>Epilepsia</i> <i></i> <i></i> 48: 2 335-341<br/>

http://publicationslist.org/massimo.cossu/refid6 2008-06-30T09:51:32Z

Of the cases with nocturnal frontal lobe epilepsy (NFLE) approximately 30% are refractory to antiepileptic medication, with several patients suffering from the effects of both ongoing seizures and disrupted sleep. From a consecutive series of 522 patients operated on for drug-resistant focal epilepsy, 21 cases (4%), whose frontal lobe seizures occurred almost exclusively (>90%) during sleep, were ...<br/><br/>L Nobili, S Francione, R Mai, F Cardinale, L Castana, L Tassi, I Sartori, G Didato, A Citterio, N Colombo, C Galli, G Lo Russo, M Cossu (2007) <i>Brain</i> <i></i> <i></i> 130: Pt 2 561-573<br/>

http://publicationslist.org/massimo.cossu/refid4 2008-06-30T09:51:32Z

PURPOSE: The optimal management of cerebral cavernous malformations (CCMs) with epileptic seizures is still a matter of debate. The aim of our study was to examine seizure outcome in the largest published series of surgically treated patients with epilepsy due to a supratentorial CCM, and to define predictors for good surgical outcome. METHODS: We retrospectively studied 168 consecutive patients w...<br/><br/>Christian R Baumann, Nicola Acciarri, Helmut Bertalanffy, Orrin Devinsky, Christian E Elger, Giorgio Lo Russo, Massimo Cossu, Uli Sure, Anuradha Singh, Hermann Stefan, Tilo Hammen, Dimitrios Georgiadis, Ralf W Baumgartner, Frederick Andermann, Adrian M Siegel (2007) <i>Epilepsia</i> <i></i> <i></i> 48: 3 559-563<br/>

http://publicationslist.org/massimo.cossu/refid3 2008-06-30T09:51:32Z

BACKGROUND: There is compelling evidence indicating that sleep plays a crucial role in the consolidation of new declarative, hippocampus-dependent memories. Given the increasing interest in the spatiotemporal relationships between cortical and hippocampal activity during sleep, this study aimed to shed more light on the basic features of human sleep in the hippocampus. METHODOLOGY/PRINCIPAL FINDIN...<br/><br/>Fabio Moroni, Lino Nobili, Giuseppe Curcio, Fabrizio De Carli, Fabiana Fratello, Cristina Marzano, Luigi De Gennaro, Franco Ferrillo, Massimo Cossu, Stefano Francione, Giorgio Lo Russo, Mario Bertini, Michele Ferrara (2007) <i>PLoS ONE</i> <i></i> <i></i> 2: 9 <br/>

http://publicationslist.org/massimo.cossu/refid10 2008-06-30T09:51:32Z

PURPOSE: Considering the epileptogenic effect of cavernoma-surrounding hemosiderin, assumptions are made that resection only of the cavernoma itself may not be sufficient as treatment of symptomatic epilepsy in patients with cavernous malformations. The purpose of this study was to test the hypothesis whether seizure outcome after removal of cavernous malformations may be related to the extent of ...<br/><br/>Christian R Baumann, Bernhard Schuknecht, Giorgio Lo Russo, Massimo Cossu, Alberto Citterio, Frederick Andermann, Adrian M Siegel (2006) <i>Epilepsia</i> <i></i> <i></i> 47: 3 563-566<br/>

http://publicationslist.org/massimo.cossu/refid9 2008-06-30T09:51:32Z

We describe the case of a patient with nocturnal frontal lobe epilepsy, presenting with periodic leg movements during sleep and complaining of excessive daytime sleepiness. With the support of intracerebral electroencephalogram recordings and the corroboration of the postoperative outcome, periodic leg movements during sleep and excessive daytime sleepiness appeared to be associated to enhanced ar...<br/><br/>Lino Nobili, Ivana Sartori, Michele Terzaghi, Francione Stefano, Roberto Mai, Laura Tassi, Liborio Parrino, Massimo Cossu, Giorgio Lo Russo (2006) <i>Sleep</i> <i></i> <i></i> 29: 5 701-704<br/>

http://publicationslist.org/massimo.cossu/refid8 2008-06-30T09:51:32Z

BACKGROUND: Stereotactic placement of intracerebral multilead electrodes for chronic EEG recording of seizures or stereoelectroencephalography (SEEG) was introduced 50 years ago at Saint Anne Hospital in Paris, France for the presurgical evaluation of patients with drug-resistant focal epilepsy. SEEG explorations are indicated whenever the noninvasive tests fail to adequately localize the epilepto...<br/><br/>M Cossu, F Cardinale, L Castana, L Nobili, I Sartori, G Lo Russo (2006) <i>Childs Nerv Syst</i> <i></i> <i></i> 22: 8 766-778<br/>

http://publicationslist.org/massimo.cossu/refid7 2008-06-30T09:51:32Z

Altered excitatory synaptic activity is likely a key factor in the neuronal hyperexcitability of developmental cerebral malformations. Using a combined morphologic and molecular approach, we investigated the NMDA receptor and related protein composition in human epileptic patients affected by periventricular nodular heterotopia, subcortical band heterotopia, or focal cortical dysplasia. Our result...<br/><br/>Adele Finardi, Fabrizio Gardoni, Stefania Bassanini, Giovanni Lasio, Massimo Cossu, Laura Tassi, Claudio Caccia, Franco Taroni, Giorgio LoRusso, Monica Di Luca, Giorgio Battaglia (2006) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 65: 9 883-893<br/>

http://publicationslist.org/massimo.cossu/refid16 2008-06-30T09:51:32Z

Focal cortical dysplasia of Taylor type (FCDT) usually presents with seizures at an early age, whereas adult onset of epilepsy is uncommon. We reviewed the medical records of 213 patients with FCDT. In 21 patients (10%), age at seizure onset ranged from 18 to 55 years (mean 25.3). The outcome of seizures in patients with FCDT and adult-onset epilepsy seems favorable vs childhood-onset seizures.<br/><br/>A M Siegel, G D Cascino, C E Elger, O Devinsky, R Laff, S Najjar, M R Sperling, G LoRusso, M Cossu, H Urbach, E Aronica, F B Meyer, B W Scheithauer, F Dubeau, F Andermann (2005) <i>Neurology</i> <i></i> <i></i> 64: 10 1771-1774<br/>

http://publicationslist.org/massimo.cossu/refid15 2008-06-30T09:51:32Z

OBJECTIVE: To report on indications, surgical technique, results, and morbidity of stereoelectroencephalography (SEEG) in the presurgical evaluation of patients with drug-resistant focal epilepsy. METHODS: Two-hundred fifteen stereotactic implantations of multilead intracerebral electrodes were performed in 211 patients (4 patients were explored twice), who showed variable patterns of localizing i...<br/><br/>Massimo Cossu, Francesco Cardinale, Laura Castana, Alberto Citterio, Stefano Francione, Laura Tassi, Alim L Benabid, Giorgio Lo Russo (2005) <i>Neurosurgery</i> <i></i> <i></i> 57: 4 706-18; discussion 706-18<br/>

http://publicationslist.org/massimo.cossu/refid17 2008-06-30T09:51:32Z

We present the results of a retrospective study on 10 patients operated on for intractable epilepsy associated with nodular heterotopia as identified by high resolution MRI. Seven patients had unilateral heterotopia, one patient had symmetric bilateral heterotopia and two patients had asymmetric bilateral heterotopia. By stereo-electroencephalogram (SEEG) (nine patients) interictal activity within...<br/><br/>L Tassi, N Colombo, M Cossu, R Mai, S Francione, G Lo Russo, C Galli, M Bramerio, G Battaglia, R Garbelli, A Meroni, R Spreafico (2005) <i>Brain</i> <i></i> <i></i> 128: Pt 2 321-337<br/>

http://publicationslist.org/massimo.cossu/refid14 2008-06-30T09:51:32Z

OBJECT: The authors report on indications for, techniques of, and results of stereoelectroencephalography (stereo-EEG) monitoring in the presurgical evaluation of childhood drug-resistant focal epilepsy. METHODS: Thirty-five children (24 boys and 11 girls; mean age 8.8 +/- 3.9 years; mean age at seizure onset 2.1 +/- 2.2 years) underwent 37 tailored stereotactic placements of intracerebral, multil...<br/><br/>Massimo Cossu, Francesco Cardinale, Nadia Colombo, Roberto Mai, Lino Nobili, Ivana Sartori, Giorgio Lo Russo (2005) <i>J Neurosurg</i> <i></i> <i></i> 103: 4 Suppl 333-343<br/>

http://publicationslist.org/massimo.cossu/refid11 2008-06-30T09:51:32Z

Hyperkinetic seizures are considered a typical manifestation of nocturnal frontal lobe epilepsy (NFLE). Patients with temporal lobe epilepsy with mainly sleep-related seizures have been described; however they commonly lack hyperkinetic activity and seizure frequency is low. We retrospectively analysed our population of 442 consecutive patients surgically treated between January 1996 and January 2...<br/><br/>R Mai, I Sartori, S Francione, L Tassi, L Castana, F Cardinale, M Cossu, A Citterio, N Colombo, G Lo Russo, L Nobili (2005) <i>Neurol Sci</i> <i></i> <i></i> 26 Suppl 3: s220-s224<br/>

http://publicationslist.org/massimo.cossu/refid12 2008-06-30T09:51:32Z

The clinical features of nocturnal frontal lobe epilepsy (NFLE) consist of a spectrum of paroxysmal motor manifestations ranging from minor motor events (MMEs) to paroxysmal arousals (PAs) and major seizures. During MMEs and PAs scalp EEG generally does not show definite ictal abnormalities. We describe the clinical and electrophysiological features of three patients affected by drug-resistant NFL...<br/><br/>L Nobili, I Sartori, M Terzaghi, L Tassi, R Mai, S Francione, M Cossu, F Cardinale, L Castana, G Lo Russo (2005) <i>Neurol Sci</i> <i></i> <i></i> 26 Suppl 3: s215-s219<br/>

http://publicationslist.org/massimo.cossu/refid13 2008-06-30T09:51:32Z

It is commonly assumed that interictal spikes (ISs) in focal epilepsies set off a period of inhibition that transiently reduces tissue excitability. Post-spike inhibition was described in experimental models but was never demonstrated in the human epileptic cortex. In the present study post-spike excitability was retrospectively evaluated on intracerebral stereo-electroencephalographic recordings ...<br/><br/>Marco Curtis, Laura Tassi, Giorgio Lo Russo, Roberto Mai, Massimo Cossu, Stefano Francione (2005) <i>Eur J Neurosci</i> <i></i> <i></i> 22: 11 2971-2976<br/>

http://publicationslist.org/massimo.cossu/refid18 2008-06-30T09:51:32Z

Sleep-related hyperkinetic seizures are a common feature of nocturnal frontal lobe epilepsy. Although sleep-related seizures with a temporal lobe origin have been reported, they commonly lack hyperkinetic activity. The authors describe three patients with sleep-related seizures characterized by frenetic, agitated, hyperactive movements (bimanual/bipedal activity, rocking, axial, pelvic, and hemiba...<br/><br/>L Nobili, M Cossu, R Mai, L Tassi, F Cardinale, L Castana, A Citterio, I Sartori, G Lo Russo, S Francione (2004) <i>Neurology</i> <i></i> <i></i> 62: 3 482-485<br/>

http://publicationslist.org/massimo.cossu/refid22 2008-06-30T09:51:32Z

The authors performed an MRI, stereo-EEG, and pathology study on a woman with subcortical band heterotopia and partial epilepsy. Clinical manifestations of seizures always started when ictal discharges were present in outer and heterotopic cortices. Simultaneous activation of both cortices and presence of differentiated neurons in the white matter and the heterotopia strongly suggest that the cort...<br/><br/>R Mai, L Tassi, M Cossu, S Francione, G Lo Russo, R Garbelli, A Ferrario, C Galli, F Taroni, A Citterio, R Spreafico (2003) <i>Neurology</i> <i></i> <i></i> 60: 11 1834-1838<br/>

http://publicationslist.org/massimo.cossu/refid21 2008-06-30T09:51:32Z

Malformations of cortical development may be associated with drug-resistant partial epilepsy suitable for surgical therapy. From the anatomopathological point of view, this categorisation has been used in reference to a wide range of alterations of the cortical mantle. Focal cortical dysplasias represent the main group of malformations of cortical development, but there are also other types of alt...<br/><br/>Giorgio Lo Russo, Laura Tassi, Massimo Cossu, Francesca Cardinale, Roberto Mai, Laura Castana, Nadia Colombo, Manuela Bramerio (2003) <i>Epileptic Disord</i> <i></i> <i></i> 5 Suppl 2: S115-S123<br/>

http://publicationslist.org/massimo.cossu/refid19 2008-06-30T09:51:32Z

We report a presurgical fMRI study and a longitudinal behavioral and structural MRI study in a 26-year-old right-handed woman with drug-resistant epilepsy of the supplementary motor region with cytoarchitectural dysplasia and minimal cortico-subcortical gliotic damage. fMRI scans were acquired during a silent phonemic verbal fluency task (VF), an automatic counting task (CT), and a finger-tapping ...<br/><br/>C Deblieck, G Pesenti, P Scifo, F Fazio, E Bricolo, G Lo Russo, G Scialfa, M Cossu, G Bottini, E Paulesu (2003) <i>Neuroimage</i> <i></i> <i></i> 20: 4 2225-2234<br/>

http://publicationslist.org/massimo.cossu/refid20 2008-06-30T09:51:32Z

PURPOSES: To show the results of the investigation conducted with intracerebral electrodes in a patient with drug-resistant nocturnal frontal lobe epilepsy, characterized by sleep-related paroxysmal motor attacks of increasing complexity ranging from simple and brief stereotyped motor events to paroxysmal arousals and major attacks. METHODS: The patient was studied with long-term video-stereo-elec...<br/><br/>Lino Nobili, Stefano Francione, Roberto Mai, Laura Tassi, Francesco Cardinale, Laura Castana, Ivana Sartori, Giorgio Lo Russo, Massimo Cossu (2003) <i>Sleep</i> <i></i> <i></i> 26: 7 883-886<br/>

http://publicationslist.org/massimo.cossu/refid23 2008-06-30T09:51:32Z

Since the original description by Taylor, the term focal cortical dysplasia has been used to refer to a wide range of alterations of the cortical mantle. More recently, these conditions have been described from neuroimaging, neuropathological and genetic standpoints, generating several classifications. It is widely recognized that these classifications are unsatisfactory. We propose a simplified c...<br/><br/>L Tassi, N Colombo, R Garbelli, S Francione, G Lo Russo, R Mai, F Cardinale, M Cossu, A Ferrario, C Galli, M Bramerio, A Citterio, R Spreafico (2002) <i>Brain</i> <i></i> <i></i> 125: Pt 8 1719-1732<br/>

http://publicationslist.org/massimo.cossu/refid25 2008-06-30T09:51:32Z

The release of [(3)H]-dopamine ([(3)H]-DA) from human neocortex nerve terminals was studied in synaptosomes prepared from brain specimens removed in neurosurgery and exposed during superfusion to different releasing stimuli. Treatment with 15 mM KCl, 100 microM 4-aminopyridine, 1 microM ionomycin or 30 mM caffeine elicited almost identical overflows of tritium. Removal of external Ca(2+) ions abol...<br/><br/>G Bonanno, R Sala, L Cancedda, P Cavazzani, M Cossu, M Raiteri (2000) <i>Br J Pharmacol</i> <i></i> <i></i> 129: 8 1780-1786<br/>

http://publicationslist.org/massimo.cossu/refid24 2008-06-30T09:51:32Z

INTRODUCTION: In order to define accurately the relationship between EEG components (spindles, delta and theta frequencies) and the occurrence of interictal epileptiform discharges (IED) during sleep in partial epilepsy, a correlation study between spike overnight distribution and EEG spectral power time series was performed. METHODS: Eighteen patients (mean age: 24.7+/-5.5 years) affected by part...<br/><br/>F Ferrillo, M Beelke, F De Carli, M Cossu, C Munari, G Rosadini, L Nobili (2000) <i>Clin Neurophysiol</i> <i></i> <i></i> 111: 5 916-923<br/>

http://publicationslist.org/massimo.cossu/refid26 2008-06-30T09:51:32Z

BACKGROUND: Little information is available about the extent and the time course of possible impairment of cerebral circulation occurring after aneurysmal subarachnoid haemorrhage (SAH). The aim of this study was to correlate cerebral autoregulation, neurological impairment at surgery and timing of surgery in patients with ruptured intracerebral aneurysms. METHODS: Cortical blood flow (CoBF) was m...<br/><br/>M Cossu, S Gennaro, A Rossi, M A Balestrero, F Cella, G L Viale (1999) <i>J Neurosurg Sci</i> <i></i> <i></i> 43: 2 99-105; discussion 105<br/>

http://publicationslist.org/massimo.cossu/refid28 2008-06-30T09:51:32Z

Dopamine (DA) autoreceptors expressed at DA nerve terminals regulate DA release. Considerable evidence has indicated that, in rodents, these autoreceptors belong to the D2 type of the DA receptor family, which, in turn, comprises the D2, D3 and D4 subtypes. We investigated here, for the first time, the subclassification of native human DA autoreceptors by studying the release of [3H]DA evoked by e...<br/><br/>E Fedele, G Fontana, C Munari, M Cossu, M Raiteri (1999) <i>Eur J Neurosci</i> <i></i> <i></i> 11: 7 2351-2358<br/>

http://publicationslist.org/massimo.cossu/refid27 2008-06-30T09:51:32Z

BACKGROUND: The surgical management of pure apical tumours of the orbit may be problematic with traditional approaches. A postero-lateral approach, specifically designed for apical growths, provides a more favourable angle of vision through a relatively small bone opening. METHODS: A series of 103 consecutive cases of intraorbital tumours, operated on in a community-based institution, was retrospe...<br/><br/>F Carta, D Siccardi, M Cossu, C Viola, M Maiello (1998) <i>J Neurosurg Sci</i> <i></i> <i></i> 42: 4 185-188<br/>

http://publicationslist.org/massimo.cossu/refid29 2008-06-30T09:51:32Z

1. Nitric oxide (NO) synthase activity was studied in slices of human temporal cortex samples obtained in neurosurgery by measuring the conversion of L-[3H]-arginine to L-[3H]-citrulline. 2. Elevation of extracellular K+ to 20, 35 or 60 mM concentration-dependently augmented L-[3H]-citrulline production. The response to 35 mM KCl was abolished by N(G)-nitro-L-arginine (100 microM) demonstrating NO...<br/><br/>G Fontana, E Fedele, M Cossu, C Munari, M Raiteri (1997) <i>Br J Pharmacol</i> <i></i> <i></i> 122: 5 930-934<br/>

http://publicationslist.org/massimo.cossu/refid30 2008-06-30T09:51:32Z

Prolactin (PRL) circulates as multiple molecular weight variants: glycosylated phosphorylated, deamidated and sulphated forms. The profiles of the forms, as determined by isoelectrofocusing (IEF), differ in physiological and pathological conditions. The case of a 72-year-old woman affected by an invasive prolactinoma is described. The patient had undergone surgical treatment followed by radiothera...<br/><br/>R Guido, S Valenti, L Foppiani, D De Martini, M Cossu, M Giusti (1997) <i>J Endocrinol Invest</i> <i></i> <i></i> 20: 5 289-293<br/>

http://publicationslist.org/massimo.cossu/refid31 2008-06-30T09:51:32Z

A modification of the lateral orbitotomy is reported for the microsurgical approach to tumors located in the posterior intraconal space. The orbital apex is entered through a small bone opening on the orbital and temporal portions of the greater wing of the sphenoid, with the lesser sphenoidal wing, the orbital plate of the frontal bone, and the lateral orbital rim being left intact. This surgical...<br/><br/>M Cossu, A Pau, G L Viale (1995) <i>Minim Invasive Neurosurg</i> <i></i> <i></i> 38: 3 129-131<br/>

http://publicationslist.org/massimo.cossu/refid34 2008-06-30T09:51:32Z

Out of a series of 43 cases operated on for ruptured intracranial aneurysms over a 12-month-period, 32 patients were followed up to 12 months postoperatively with repeated evaluations of cerebral blood flow, using the Xenon133 inhalation technique. No statistically significant differences in cerebral perfusion were detected between the subgroups of good-grade patients, who were submitted respectiv...<br/><br/>G L Viale, E V Sehrbundt, M Cossu, C Viola, G Rodriguez, A Pau, C Bernucci (1994) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 131: 1-2 6-11<br/>

http://publicationslist.org/massimo.cossu/refid36 2008-06-30T09:51:32Z

Forty-three patients were operated on for ruptured intracranial aneurysms during a 12-month-period. Intraoperative evaluation of cortical blood flow by means of a thermal diffusion probe was performed in 23 out of the 41 patients who were operated on for aneurysms of the anterior circulation. The autoregulation index was determined at the time of raising the systemic blood pressure after clipping ...<br/><br/>G L Viale, M Cossu, F Cella, M Balestrero, A Rossi, D Masoni (1994) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 131: 1-2 1-5<br/>

http://publicationslist.org/massimo.cossu/refid35 2008-06-30T09:51:32Z

Early changes of cerebellar and cerebral blood flow, as well as subsequent infratentorial ischaemia, were evaluated in an experimental model of cerebellar haemorrhage. Eight anaesthetized male adult Sprague-Dawley rats received an injection of autologous arterial blood (50 microliters) into the right cerebellar hemisphere. Eight animals were sham-operated and served as controls. Cerebellar blood f...<br/><br/>M Cossu, A Pau, D Siccardi, G L Viale (1994) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 131: 1-2 146-150<br/>

http://publicationslist.org/massimo.cossu/refid33 2008-06-30T09:51:32Z

As far as we know, only 20 patients with association of aneurysm and arteriovenous malformation (AVM) on the posterior inferior cerebellar artery (PICA) have been reported so far. Further three personal cases are presented here and the pertinent literature is reviewed, the coexistence of aneurysm(s) and AVM on the PICA district increases the risk of intracranial bleeding compared with patients har...<br/><br/>A Pau, M Cossu, S Turtas (1994) <i>Acta Neurol (Napoli)</i> <i></i> <i></i> 16: 1-2 52-57<br/>

http://publicationslist.org/massimo.cossu/refid32 2008-06-30T09:51:32Z

M Cossu, D Siccardi, A Pau (1994) <i>Surg Neurol</i> <i></i> <i></i> 42: 3 <br/>

http://publicationslist.org/massimo.cossu/refid39 2008-06-30T09:51:32Z

Forty-seven patients, who underwent surgery over a 34-year period by the wrapping or coating of ruptured intracranial aneurysms, have been retrospectively evaluated. The following materials were used in the surgical procedures: muscle with gelatin sponge (7 cases), gauze (2 cases), oxidized cellulose with Biobond (28 cases), Histoacryl with gauze or fascia (10 cases). The patients were monitored f...<br/><br/>M Cossu, A Pau, S Turtas, C Viola, G L Viale (1993) <i>Neurosurgery</i> <i></i> <i></i> 32: 3 344-6; discussion 347<br/>

http://publicationslist.org/massimo.cossu/refid37 2008-06-30T09:51:32Z

The association of a pituitary adenoma with a dural arteriovenous fistula supplied by the posterior branches of the middle meningeal artery and draining into the transverse sinus is reported. Among the possible etiopathogenic explanations of such an unusual association, a progressive mechanical obstacle to the dural venous blood drainage to the left wing of the compressed cavernous sinus and subse...<br/><br/>M Cossu, A Lucano, F Sardanelli, A Pau (1993) <i>Acta Neurol (Napoli)</i> <i></i> <i></i> 15: 6 442-448<br/>

http://publicationslist.org/massimo.cossu/refid38 2008-06-30T09:51:32Z

The CBF of eight patients, who underwent surgery for ruptured aneurysm, was monitored using the termodiffusion technique (TDF). The device employed in this investigation allowed a continuous monitoring in "real time" of the cortical flow. The purpose of the study was to detect disorders of autoregulation, which were evaluated with the autoregulation index (AI). Autoregulation was correlated with t...<br/><br/>A Rossi, M A Balestrero, F Cella, M Cossu, D Masoni, G Rodriguez, E Sehrbundt Viale, G Viale (1993) <i>Minerva Anestesiol</i> <i></i> <i></i> 59: 11 567-570<br/>

http://publicationslist.org/massimo.cossu/refid40 2008-06-30T09:51:32Z

Out of a consecutive series of 1082 operations performed on head-injured patients over a 9-year period, 28 cases of acute subdural haematomas (SDHs) or epidural haematomas (EDHs) occurring in patients aged between 80 and 100 years were selected. Mortality rates in these patients (100% in 2 EDHs, 88% in 26 SDHs) were significantly higher (p less than 0.01) compared with patients under 80 years (12%...<br/><br/>B Cagetti, M Cossu, A Pau, C Rivano, G Viale (1992) <i>Br J Neurosurg</i> <i></i> <i></i> 6: 3 227-231<br/>

http://publicationslist.org/massimo.cossu/refid42 2008-06-30T09:51:32Z

The temporal progression of changes in blood flow within the hemispheric cerebellar cortex, following an experimental cerebellar ipsilateral haemorrhage, was investigated in rats by using the hydrogen clearance technique. Stereotactical injection of 50 microliters of fresh autologous blood into the paramedian white matter was found to produce an early drop of cerebellar blood flow, with subsequent...<br/><br/>M Cossu, A Dorcaratto, A Pau, G Rodriguez, E Sehrbundt Viale, D Siccardi, G L Viale (1991) <i>Ital J Neurol Sci</i> <i></i> <i></i> 12: 3 Suppl 11 69-73<br/>

http://publicationslist.org/massimo.cossu/refid41 2008-06-30T09:51:32Z

A case of spinal subarachnoid hematoma at T3-T7 level is reported in a 60-year-old hunter, who developed progressive spinal cord impairment after receiving the recoil of his shotgun. Both clinical and neuroradiological investigations, including the selective spinal angiography, failed to demonstrate the origin of the bleeding. The combination of an apparently trivial spinal trauma with temporary i...<br/><br/>A Pau, M Brambilla, M Cossu, N Francaviglia, D Siccardi, C Silvestro (1991) <i>Neurochirurgia (Stuttg)</i> <i></i> <i></i> 34: 5 151-153<br/>

http://publicationslist.org/massimo.cossu/refid45 2008-06-30T09:51:32Z

Regional cerebral blood flow, recorded by the 133Xenon inhalation method, was measured preoperatively and over a five years postoperative period in six patients with completed stroke and stabilized neurological deficits, who had undergone omental transposition for revascularization of the ischaemic brain. Comparisons of the preoperative blood flow values with those recorded following surgery demon...<br/><br/>H S Goldsmith, P Bacciu, M Cossu, A Pau, G Rodriguez, G Rosadini, P Ruju, E Sehrbundt Viale, S Turtas, G L Viale (1990) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 106: 3-4 145-152<br/>

http://publicationslist.org/massimo.cossu/refid44 2008-06-30T09:51:32Z

In order to assess the actual incidence of gas bubbles trapped within acute intracranial epidural haematomas, as revealed by computed tomography (CT) of the skull, a series of 204 patients with surgically verified epidural haematomas was retrospectively reviewed. Gas bubbles were observed on CT scan in 22.5% of the cases, with the incidence rising to 37% when CT scanners of the last generation wer...<br/><br/>M Cossu, T Arcuri, B Cagetti, M Brambilla Bas, D Siccardi, A Pau (1990) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 102: 1-2 22-24<br/>

http://publicationslist.org/massimo.cossu/refid43 2008-06-30T09:51:32Z

A case of chronic subdural hematoma associated with contralateral upper monoballism is reported. Intracranial midline shift and transtentorial herniation of the ipsilateral temporal lobe were the only demonstrated CT abnormalities. Complete neurological recovery followed the evacuation of the hematoma. Direct mechanical injury caused by the marked brain compression and distortion, and transient is...<br/><br/>A Pau, M Brambilla Bas, D Siccardi, M Cossu (1990) <i>Acta Neurol (Napoli)</i> <i></i> <i></i> 12: 3 237-241<br/>

http://publicationslist.org/massimo.cossu/refid47 2008-06-30T09:51:32Z

We retrospectively examined regional cerebral blood flow values in 78 patients in the stabilized phase of stroke to evaluate the consistency of lateralization compared with computed tomographic imaging. Examinations were performed using the xenon-133 inhalation technique, and the data were processed and displayed by a computer-assisted system of our own design that allows statistical analysis in r...<br/><br/>G Rosadini, M Cossu, F De Carli, S Marenco, F Nobili, G Rodriguez (1989) <i>Stroke</i> <i></i> <i></i> 20: 9 1182-1189<br/>

http://publicationslist.org/massimo.cossu/refid48 2008-06-30T09:51:32Z

Bilateral Parkinsonism has been observed in a 60-year-old female with a chronic subdural intracranial haematoma. Scattered, poorly marginated, hypodense areas within the ipsilateral pallidus and putamen were evident on the preoperative CT scans. The rapid neurological improvement following the surgical drainage of the subdural clot and the evolution of the densitometric features of the nuclear les...<br/><br/>A Pau, M Brambilla, M Cossu, R Schoenhuber, D Siccardi, S Turtas (1989) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 96: 3-4 159-160<br/>

http://publicationslist.org/massimo.cossu/refid46 2008-06-30T09:51:32Z

Two patients with a herniated disk respectively at the level of the L4-L5 and of the L5-S1 intervertebral spaces presented with pyramidal signs, bladder paralysis and radicular impairment. The symptoms subsided immediately following surgical removal of the prolapsed disk. The role of transient ischemia in the lower segments of the spinal cord as possible cause of this uncommon clinical picture is ...<br/><br/>A Pau, M Cossu, S Turtas, G Zirattu (1989) <i>Acta Neurol (Napoli)</i> <i></i> <i></i> 11: 6 439-443<br/>

http://publicationslist.org/massimo.cossu/refid50 2008-06-30T09:51:32Z

Long term results of the surgical treatment of intracranial hydatid disease ist reported in 11 personal cases. Nine patients are alive 9 to 15 years following the operation, only one of them being disabled. The remaining two patients died respectively 6 months and 2 years after the first operation.<br/><br/>A Pau, M Brambilla, M Cossu, E Sehrbundt Viale, S Turtas (1987) <i>Acta Neurochir (Wien)</i> <i></i> <i></i> 88: 3-4 116-118<br/>

http://publicationslist.org/massimo.cossu/refid49 2008-06-30T09:51:32Z

After destruction of the thalamocortical projections of one side in 12 adult rats, the ipsilateral thalamic ventrobasal nucleus was connected with the contralateral somatosensory cortex through an autologous peripheral nerve graft. Three months after the implanting procedure, horseradish peroxidase was applied to the transected nerve. Retrograde labeling of cells occurred in all examined animals. ...<br/><br/>M Cossu, A Martelli, A Pau, E S Viale, D Siccardi, G L Viale (1987) <i>Brain Res</i> <i></i> <i></i> 415: 2 399-403<br/>

http://publicationslist.org/massimo.cossu/refid52 2008-06-30T09:51:32Z

21 patients with hydatid disease of the spine were operated on upon a 30-year period. The follow-up ranged up to 24 years. 12 cases underwent one or more reoperations, due to recurrences. 8 patients died between 1 and 21 years after the first operation. The surgical treatment usually allows only a transient remission and does not avoid recurrence or progression of the illness. Although the parasit...<br/><br/>A Pau, M Cossu, E S Viale, D Siccardi, S Turtas, G L Viale (1986) <i>Zentralbl Neurochir</i> <i></i> <i></i> 47: 4 316-321<br/>

http://publicationslist.org/massimo.cossu/refid51 2008-06-30T09:51:32Z

An increasing number of arteriovenous malformations of the posterior cranial fossa can be radically extirpated with good functional results, by using microsurgical techniques. Extensive involvement of the brain stem represents the limit for effective surgery. An anatomo-surgical classification of these lesions is presented, and the surgical indications are discussed.<br/><br/>G L Viale, T Capuzzo, M Cossu, A Pau, E Sehrbundt Viale (1986) <i>Minerva Med</i> <i></i> <i></i> 77: 25 1187-1194<br/>

http://publicationslist.org/massimo.cossu/refid53 2008-06-30T09:51:32Z

Seventeen patients with minor cerebral contusion were selected from a series of patients with head injuries of various severity, who had undergone repeat evaluations of the regional cerebral blood flow. The mean global flow (expressed as mean global initial slope index) on early examination was found to be significantly lower, compared with that recorded in healthy volunteers. A tendency towards t...<br/><br/>F Arvigo, M Cossu, B Fazio, A Gris, A Pau, G Rodriguez, G Rosadini, E Sehrbundt Viale, D Siccardi, S Turtas (1985) <i>Surg Neurol</i> <i></i> <i></i> 24: 2 211-217<br/>

http://publicationslist.org/massimo.cossu/refid54 2008-06-30T09:51:32Z

The third ventricle can be approached by performing a few surgical maneuvers: (a) dividing the ependyma on the inferolateral aspect of the choroid plexus of the lateral ventricle; (b) separating leptomeningeal bundles within the tela chorioidea, and (c) dividing the roof of the third ventricle along the stria medullaris. Main landmarks are the thalamostriate vein and the direct lateral vein. Small...<br/><br/>M Cossu, F Lubinu, G Orunesu, A Pau, E Sehrbundt Viale, M G Sini, S Turtas (1984) <i>Surg Neurol</i> <i></i> <i></i> 21: 4 325-331<br/>

http://publicationslist.org/massimo.cossu/refid55 2008-06-30T09:51:32Z

Regional cerebral blood flow (CBF) was measured in 15 healthy young volunteers in psycho-sensorial rest by the 32 probes Xe133 inhalation system. The mean hemispheric values are in good agreement with those reported in literature and obtained with a limited number of probes. The regional values of the flow in the gray matter are higher in the basal-temporal and frontal regions. This regional patte...<br/><br/>M Cossu, M Cabri, F De Carli, V Montano, G Rodriguez, A Siccardi, R Traverso, G Rosadini (1982) <i>Boll Soc Ital Biol Sper</i> <i></i> <i></i> 58: 12 766-772<br/>