Narendra Nathoo's Publications List

History of the Vertebral Venous Plexus and the Significant Contributions of Breschet and Batson.

2011-07-05T02:47:01Z

Prior to the eighteenth century, the vertebral venous plexus (VVP) received scant mention, had no clinical relevance and was largely ignored by anatomists, most likely due to its location and non - distensible nature. Gilbert Breschet in 1819 provided the first detailed anatomical description of the VVP, describing it as a large plexiform valveless network of vertebral veins consisting of three in...

Narendra Nathoo, Elizabeth C Caris, Judith A Wiener, Ehud Mendel (2011) Neurosurgery :

Reconstruction of the pelvis and lumbar-pelvic junction using 2 vascularized autologous bone grafts after en bloc resection for an iliosacral chondrosarcoma.

2011-07-05T02:47:01Z

Primary pelvic sarcomas remain challenging and complex surgical problems with significant potential for postoperative impairment of ambulation, as well as bowel, bladder, and sexual function. En bloc resection with negative tumor margins represents the best chance of control or cure as current adjuvant therapies remain ineffective. Tumor involvement of the sacrum with extension to the greater scia...

Ehud Mendel, Joel L Mayerson, Narendra Nathoo, Rick L Edgar, Carl Schmidt, Michael J Miller (2011) J Neurosurg Spine :

Nail-gun injury of the cervical spine: simple technique for removal of a barbed nail.

2011-04-17T12:46:38Z

Although nail-gun injuries are a common form of penetrating low-velocity injury, impalement with barbed nails has been underreported to date. Barbed nails are designed to resist dislodgment once embedded, and any attempt at removal may splay open the barbs along the path of entry, with the potential for significant soft-tissue and neurovascular injury. A 25-year-old man sustained a nail impalement...

Narendra Nathoo, Atom Sarkar, Gandhi Varma, Ehud Mendel (2011) J Neurosurg Spine :

Brain abscess: management and outcome analysis of a computed tomography era experience with 973 patients.

2011-07-05T02:47:01Z

Brain abscess (BA) is a neurosurgical emergency and despite significant medical advances, it remains a surgical challenge. A single institution's two decade computed tomography era management experience with BA is reported.

Narendra Nathoo, Sameer S Nadvi, Pradeep K Narotam, James R van Dellen (2011) World Neurosurg 75: 5-6 716-726

Garré disease.

2010-11-01T02:19:19Z

Narendra Nathoo, Pradeep K Narotam, James R van Dellen (2010) J Neurosurg 112: 2 475-6; author reply 476

Posterior fossa duraplasty and hydrodynamic complications.

2010-11-01T02:19:19Z

Narendra Nathoo, Pradeep K Narotam (2010) Neurosurgery 66: 5

Collagen matrix duraplasty.

2010-11-01T02:21:38Z

Narendra Nathoo, Pradeep K Narotam (2009) J Neurosurg 110: 1 192-193

Collagen matrix duraplasty for posterior fossa surgery: evaluation of surgical technique in 52 adult patients. Clinical article.

2010-11-01T02:21:38Z

OBJECT: Complete dural closure is not always possible following posterior fossa surgery, often requiring a graft to secure complete closure. The authors report their experience of using a collagen matrix as an onlay dural graft for repair of a posterior fossa dural defect. METHODS: A retrospective analysis was performed in 52 adult patients who had undergone collagen matrix duraplasty for the post...

Pradeep K Narotam, Fan Qiao, Narendra Nathoo (2009) J Neurosurg 111: 2 380-386

The first direct human blood transfusion: the forgotten legacy of George W. Crile.

2010-11-01T02:19:19Z

GEORGE W. CRILE is best known as the father of physiological surgery in the United States, a pioneer surgeon, an innovator and inventor, a founding member of the American College of Surgeons, and the principal founder of the Cleveland Clinic Foundation. However, Crile's legacy of performing the first direct blood transfusion in humans has been all but forgotten, even though the results were publis...

Narendra Nathoo, Frederick K Lautzenheiser, Gene H Barnett (2009) Neurosurgery 64: 3 Suppl 20-6; discussion 26-7

Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy.

2010-11-01T02:19:19Z

OBJECT: Cerebral ischemia is the leading cause of preventable death in cases of major trauma with severe traumatic brain injury (TBI). Intracranial pressure (ICP) control and cerebral perfusion pressure (CPP) manipulation have significantly reduced the mortality but not the morbidity rate in these patients. In this study, the authors describe their 5-year experience with brain tissue oxygen (PbtO(...

Pradeep K Narotam, John F Morrison, Narendra Nathoo (2009) J Neurosurg 111: 4 672-682

Management of hypertensive emergencies in acute brain disease: evaluation of the treatment effects of intravenous nicardipine on cerebral oxygenation.

2010-11-01T02:21:38Z

OBJECT: Inappropriate sudden blood pressure (BP) reductions may adversely affect cerebral perfusion. This study explores the effect of nicardipine on regional brain tissue O(2) (PbtO(2)) during treatment of acute hypertensive emergencies. METHODS: A prospective case-control study was performed in 30 patients with neurological conditions and clinically elevated BP. All patients had a parenchymal Pb...

Pradeep K Narotam, Varun Puri, John M Roberts, Charles Taylon, Yashail Vora, Narendra Nathoo (2008) J Neurosurg 109: 6 1065-1074

Collagen matrix duraplasty for cranial and spinal surgery: a clinical and imaging study.

2010-11-01T02:21:38Z

OBJECT: The repair of dural defects is controversial in contemporary neurosurgery. To date, collagen-based products remain a continued area of interest in the development of dural grafts. The authors conducted a prospective case-control study in which they evaluated collagen matrix in the repair of dural defects following cranial and spinal surgery by using specific clinical and magnetic resonance...

Pradeep K Narotam, Kesava Reddy, Derek Fewer, Fan Qiao, Narendra Nathoo (2007) J Neurosurg 106: 1 45-51

The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas.

2010-11-01T02:21:38Z

OBJECTIVE: Meningiomas are common brain tumors with somatostatin receptors that bind octreotide. We report the use of (111)indium-octreotide brain scintigraphy (OBS) for the non-invasive differentiation of meningiomas from other cranial dural-based pathology. METHODS: A retrospective analysis of our experience with OBS for non-invasive identification of meningiomas was performed. Two neuroradiolog...

Narendra Nathoo, Kene Ugokwe, Albert S Chang, Liang Li, Jeffrey Ross, John H Suh, Michael A Vogelbaum, Gene H Barnett (2007) J Neurooncol 81: 2 167-174

Increased expression of 5-lipoxygenase in high-grade astrocytomas.

2010-11-01T02:21:38Z

OBJECTIVE: 5-Lipoxygenase (5-LO) oxidizes arachidonic acid into proinflammatory eicosanoids that may promote tumorigenesis. In this study, we investigated whether 5-LO is expressed in human astrocytomas and what effect its expression may have on patient outcome. METHODS: Increased 5-LO messenger ribonucleic acid and protein expression was detected by the polymerase chain reaction and antibody-base...

Narendra Nathoo, Richard A Prayson, Judy Bondar, Linda Vargo, Susana Arrigain, Edward J Mascha, John H Suh, Gene H Barnett, Mladen Golubic (2006) Neurosurgery 58: 2 347-54; discussion 347-54

Gamma knife radiosurgery for glomus jugulare tumors: volumetric analysis in 17 patients.

2010-11-01T02:21:38Z

OBJECTIVE: Stereotactic radiosurgery has been used increasingly for the treatment of glomus jugulare tumors. The authors report their experience treating these tumors using gamma knife radiosurgery (GKRS), documenting the clinical and radiological outcome. METHODS: A retrospective analysis identified 17 patients with glomus jugulare tumors who underwent GKRS. Besides analysis of clinical outcome, ...

Abhay Varma, Narendra Nathoo, Gennady Neyman, John H Suh, Jeffrey Ross, John Park, Gene H Barnett (2006) Neurosurgery 59: 5 1030-6; discussion 1036

Pathobiology of brain metastases.

2010-11-01T02:23:11Z

Brain metastasis is a major cause of systemic cancer morbidity and mortality. Many factors participate in the development and maintenance of brain metastases. The survival of the metastasis depends upon crucial interactions between tumour cells and the brain microenvironment during its development at the new site. This review focuses on the pathobiological mechanisms involved in the establishment ...

N Nathoo, A Chahlavi, G H Barnett, S A Toms (2005) J Clin Pathol 58: 3 237-242

In touch with robotics: neurosurgery for the future.

2010-11-01T02:23:11Z

The introduction of multiple front-end technologies during the past quarter century has generated an emerging futurism for the discipline of neurological surgery. Driven primarily by synergistic developments in science and engineering, neurosurgery has always managed to harness the potential of the latest technical developments. Robotics represents one such technology. Progress in development of t...

Narendra Nathoo, M Cenk Cavuşoğlu, Michael A Vogelbaum, Gene H Barnett (2005) Neurosurgery 56: 3 421-33; discussion 421-33

Blind transpyloric nasojejunal versus nasogastric tube intubation in severe head injuries: a preliminary report.

2010-11-01T02:23:11Z

AIM: To compare the efficacy of blind transpyloric placement using a specifically designed nasojejunal tube (NJT) versus a standard nasogastric tube (NGT) in severe head injury (SHI). METHODS: This was a randomised trial conducted in a neurosurgical intensive care unit. Fourteen patients were enrolled with a Glasgow Coma Score (GCS) less than 8 (mean 6.8 SEM+/-0.36). Patients were randomised to re...

L V Marino, Praneel Ramchandra, Narendra Nathoo (2005) J Clin Neurosci 12: 4 435-437

Cushing, the Mayos, and George Crile.

2010-11-01T02:21:38Z

Narendra Nathoo, Frederick K Lautzenheiser, Gene Barnett (2005) J Neurosurg 103: 2 392-3; author reply 393

Trigeminal nerve schwannoma with ancient change. Case report and review of the literature.

2010-11-01T02:23:11Z

Ancient change in a schwannoma is a histological variant typically found in longstanding tumors. Histologically, the tumor has biphasic features typical of a schwannoma with evidence of degenerative changes that may complicate diagnosis. The authors report on a 23-year-old man with no features of neurofibromatosis who presented with headaches, blurred vision, and ataxic gait. Magnetic resonance im...

Kene Ugokwe, Narendra Nathoo, Richard Prayson, Gene H Barnett (2005) J Neurosurg 102: 6 1163-1165

George W. Crile, Ohio's first neurosurgeon, and his relationship with Harvey Cushing.

2010-11-01T02:21:38Z

Much has been written about Harvey Cushing, his contributions to neurosurgery, and his relationship with many of his contemporaries. Nevertheless, there is no independent report documenting his relationship with Ohio's first neurosurgeon, George W. Crile. Crile's role as a neurosurgeon is limited to the late nineteenth and early twentieth centuries, and he is best remembered for other accomplishme...

Narendra Nathoo, Frederick K Lautzenheiser, Gene H Barnett (2005) J Neurosurg 103: 2 378-386

Mapping prosody: correlation of functional magnetic resonance imaging with intraoperative electrocorticography recordings in a patient with a right-sided temporooccipital glioma. Case illustration.

2010-11-01T02:21:38Z

Narendra Nathoo, Dileep Nair, Michael Phillips, Michael A Vogelbaum (2005) J Neurosurg 103: 5

Epidermal growth factor receptor antagonists: novel therapy for the treatment of high-grade gliomas.

2010-11-01T02:23:11Z

Overactivation of epidermal growth factor receptor (EGFR) signaling has been recognized as an important step in the pathogenesis and progression of multiple forms of cancer of epithelial origin. This knowledge has led to a surge of interest in novel anticancer therapies targeting key constituents of the EGFR signal transduction pathway. Several molecular strategies have been developed recently to ...

Narendra Nathoo, Samuel Goldlust, Michael A Vogelbaum (2004) Neurosurgery 54: 6 1480-8; discussion 1488-9

W. James Gardner: pioneer neurosurgeon and inventor.

2010-11-01T02:24:18Z

W. James Gardner, a skillful neurosurgeon and inventor, is best remembered for his cervical tongs and hydrodynamic theory of syringomyelia. A pioneer of modern neurosurgery, Gardner trained under Charles Frazier in Philadelphia, and in 1929 he moved to Ohio where he became chief of neurosurgery at the Cleveland Clinic, a position he was to hold for the next 33 years. A large surgical practice made...

Narendra Nathoo, Marc R Mayberg, Gene H Barnett (2004) J Neurosurg 100: 5 965-973

The eicosanoid cascade: possible role in gliomas and meningiomas.

2010-11-01T02:24:18Z

Eicosanoids constitute a large family of biologically active lipid mediators that are produced by two enzyme classes, cyclooxygenases (COX-1 and COX-2) and lipoxygenases (5-LO, 12-LO, and 15-LO). Increasing evidence suggests that in addition to a variety of epithelial malignancies, the two most common types of human brain tumour, gliomas and meningiomas, aberrantly overexpress eicosanoid producing...

N Nathoo, G H Barnett, M Golubic (2004) J Clin Pathol 57: 1 6-13

Evaluation of the behaviour of a thermal diffusion sensor in a high field strength magnetic resonance system: an experimental study.

2010-11-01T02:24:18Z

Patients with acute brain pathology requiring ferromagnetic bio-medical implants for on-going invasive monitoring are largely excluded from the benefits of MRI scanning. We evaluated the behaviour of a thermal diffusion cortical blood flow (TD-CBF) sensor both in vitro (phantom gelatin model) and in vivo environments in a high field strength MRI system. Two baboons underwent cranial subdural impla...

Narendra Nathoo, Sameer S Nadvi, Duncan Royston, Mahesh Rana, Premjith Gathiram, Pratistadevi K Ramdial, James R van Dellen (2004) J Clin Neurosci 11: 1 61-65

Conservative neurological management of intracranial epidural abscesses in children.

2010-11-01T02:23:11Z

Narendra Nathoo, James R van Dellen, S Sameer Nadvi (2004) Neurosurgery 55: 1 263-4; author reply 264

Metastases to the brain: current management perspectives.

2010-11-01T02:23:11Z

Brain metastases are ten-times more common than primary brain tumors and are a common complication in patients with systemic cancer. The most common sources of brain metastases are lung and breast cancers, although in 15% of patients, the primary site is unknown. Optimal treatment is dependant upon tumor location, size, number of tumors and status of the systemic disease. Currently, management of ...

Narendra Nathoo, Steven A Toms, Gene H Barnett (2004) Expert Rev Neurother 4: 4 633-640

Influence of apoptosis on neurological outcome following traumatic cerebral contusion.

2010-11-01T02:23:11Z

OBJECT: Apoptosis has increasingly been implicated in the pathobiology of traumatic brain injury (TBI). The present study was undertaken to confirm the presence of apoptosis in the periischemic zone (PIZ) of traumatic cerebral contusions and to determine the role of apoptosis, if any, in neurological outcome. METHODS: Brain tissue harvested at Wentworth Hospital from the PIZ in 29 patients with tr...

Narendra Nathoo, Pradeep K Narotam, Devendra K Agrawal, Catherine A Connolly, James R van Dellen, Gene H Barnett, Runjan Chetty (2004) J Neurosurg 101: 2 233-240

Collagen matrix (DuraGen) in dural repair: analysis of a new modified technique.

2010-11-01T02:23:11Z

STUDY DESIGN: Retrospective review of 110 patients undergoing spinal dural repair and regeneration using an onlay, suture-free, 3-dimensional-collagen matrix graft (DuraGen) over an 8-year period (1995-2003). OBJECTIVES: Technique appraisal of collagen matrix to repair spinal dura following incidental durotomy, spinal tumor surgery, and trauma. SUMMARY OF BACKGROUND DATA: Traditional methods of sp...

Pradeep K Narotam, Sunil José, Narendra Nathoo, Charles Taylon, Yashail Vora (2004) Spine (Phila Pa 1976) 29: 24 2861-7; discussion 2868-9

The modern brain tumor operating room: from standard essentials to current state-of-the-art.

2010-11-01T02:23:11Z

It is just over a century since successful brain tumor resection. Since then the diagnosis, imaging, and management of brain tumors have improved, in large part due to technological advances. Similarly, the operating room (OR) for brain tumor surgery has increased in complexity and specificity with multiple forms of equipment now considered necessary as technical adjuncts. It is evident that the t...

Gene H Barnett, Narendra Nathoo (2004) J Neurooncol 69: 1-3 25-33

Evaluation of an antibiotic-impregnated shunt system for the treatment of hydrocephalus.

2010-11-01T02:24:18Z

OBJECT: Staphylococcus species are the most common organisms responsible for infection following implantable cerebrospinal fluid (CSF) diversionary procedures. The role of an antibiotic-impregnated shunt (AIS) system in the prevention of shunt infection has remained unclear because no human clinical trial has been reported on thus far. In this study, the authors assess an AIS system with respect t...

Soma T Govender, Narendra Nathoo, James R van Dellen (2003) J Neurosurg 99: 5 831-839

Visuospatial deficits in children 3-7 years old with shunted hydrocephalus.

2010-11-01T02:24:18Z

OBJECTIVE: To define non-verbal intelligence deficits in children 3-7 years of age following shunted hydrocephalus (HCP). DESIGN: Prospective randomised single-blinded study. Thirty shunted HCP (study) and 30 cardiac (control) patients between the ages of 3 and 7 years were compared on eight non-verbal subtests of the Junior South African Individual Scales (JSAIS). SETTING: Department of Neurosurg...

Serena V Frank, Theophilus Lazarus, Narendra Nathoo (2003) S Afr Med J 93: 11 865-868

Robotics and neurosurgery.

2010-11-01T02:24:18Z

Ultimately, neurosurgery performed via a robotic interface will serve to improve the standard of a neurosurgeon's skills, thus making a good surgeon a better surgeon. In fact, computer and robotic instrumentation will become allies to the neurosurgeon through the use of these technologies in training, diagnostic, and surgical events. Nonetheless, these technologies are still in an early stage of d...

Narendra Nathoo, Todd Pesek, Gene H Barnett (2003) Surg Clin North Am 83: 6 1339-1350

Combined spinal subdural tuberculous empyema and intramedullary tuberculoma in an HIV-positive patient.

2010-11-01T02:24:18Z

Tuberculous involvement of the spinal subdural and intramedullary compartments is extremely uncommon. Simultaneous involvement of both compartments has never been reported, to our knowledge. We present an HIV-positive patient with such kind of combined involvement. Diagnosis was made on the basis of a prior history of pulmonary tuberculous infection and a positive therapeutic response to antituber...

Giovanni Alessi, Marc Lemmerling, Narendra Nathoo (2003) Eur Radiol 13: 8 1899-1901

To determine the effect of metoclopramide on gastric emptying in severe head injuries: a prospective, randomized, controlled clinical trial.

2010-11-01T02:25:13Z

To determine the effect of 8-hourly administration of 10 mg intravenous metoclopramide, over a 48-h period on gastric emptying in severe head injury (SHI), 22 patients were prospectively randomized (Glasgow Coma Score of 3-8) to receive 2 ml of intravenous metoclopramide or 2 ml of 5% saline 8-hourly for 48 h. Baseline and serial blood paracetamol absorption assays were performed at time (t) = 0, ...

L V Marino, E M Kiratu, S French, N Nathoo (2003) Br J Neurosurg 17: 1 24-28

Telemedicine and neurosurgery: experience of a regional unit based in South Africa.

2010-11-01T02:25:13Z

We carried out a retrospective analysis of all emergency referrals to the neurosurgery department of the Wentworth Hospital from 1996 to 1999. The hospital provided a service to seven peripheral hospitals with computerized tomography (CT) scanners and 46 hospitals without, in the province of KwaZulu Natal. By the end of the study, six of the hospitals with CT scanners had facilities for teleradiol...

R Jithoo, P V Govender, P Corr, N Nathoo (2003) J Telemed Telecare 9: 2 63-66

Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.

2010-11-01T02:25:13Z

Apolipoprotein E (APOE) is thought to be responsible for the transportation of lipids within the brain, maintaining structural integrity of the microtubule within the neurone, and assisting with neural transmission. Possession of the APOE epsilon4 allele has also been shown to influence neuropathological findings in patients who die from traumatic brain injury, including the accumulation of amyloi...

N Nathoo, R Chetty, J R van Dellen, G H Barnett (2003) Mol Pathol 56: 3 132-136

Apolipoprotein E polymorphism and outcome after closed traumatic brain injury: influence of ethnic and regional differences.

2010-11-01T02:25:13Z

OBJECT: The presence of the apolipoprotein E-epsilon4 (APOE-epsilon4) allele is reported to be associated with poor outcome after traumatic brain injury (TBI). This study was performed to determine if the presence of the APOE-epsilon4 allele influenced outcome in a cohort of black patients with TBI who had homogeneous neuropathological findings. METHODS: Venous blood was collected at the time of a...

Narendra Nathoo, Runjan Chetry, James R van Dellen, Catherine Connolly, Richard Naidoo (2003) J Neurosurg 98: 2 302-306

Long-term results after radiosurgery for benign intracranial tumors.

2010-11-01T02:24:18Z

BACKGROUND: Stereotactic radiosurgery is the principal therapeutic alternative to resecting benign intracranial tumors. The goals of radiosurgery are the long-term prevention of tumor growth, the maintenance of patient function, and the prevention of new neurological deficits or adverse radiation effects. Evaluation of long-term outcomes more than 10 years after radiosurgery is needed. METHODS: We...

Douglas Kondziolka, Narendra Nathoo, John C Flickinger, Ajay Niranjan, Ann H Maitz, L Dade Lunsford (2003) Neurosurgery 53: 4 815-21; discussion 821-2

Endoscopic aqueductoplasty and stenting--report of initial experience.

2010-11-01T02:25:13Z

Narendra Nathoo, Erastus Kiratu, Nirmula Dasi (2002) S Afr Med J 92: 1 51-52

Aspirin and trauma--uncommon and preventable causes of intracranial haemorrhage in the newborn.

2010-11-01T02:25:13Z

M Adhikari, T Pillay, N Nathoo (2002) S Afr Med J 92: 5 345-346

Home-made gun injury: spontaneous version and anterior migration of bullet.

2010-11-01T02:25:13Z

We report a unique case of a self-inflicted brain injury using an ingenious home-made gun with spontaneous anterior migration of the intact bullet. On admission, the patient was fully conscious with no neurological deficits. Computed tomography (CT) confirmed a penetrating missile injury with transventricular across midline trajectory and multi-lobe injury with the bullet lodged in the occipital l...

G Alessi, S Aiyer, N Nathoo (2002) Br J Neurosurg 16: 4 381-384

Civilian infratentorial gunshot injuries: outcome analysis of 26 patients.

2010-11-01T02:25:13Z

BACKGROUND: Craniocerebral missile injuries have steadily increased to become the most common form of penetrating neurotrauma in our environment resulting in continued morbidity and neuropsychological sequelae. Civilian infratentorial gunshot injuries are uncommon but generally regarded as fatal injuries, with many patients dying before reaching hospital. METHODS: A retrospective analysis of 1,069...

Narendra Nathoo, Stewart H Chite, Philip J Edwards, James R van Dellen (2002) Surg Neurol 58: 3-4 225-32; discussion 232-3

Craniotomy improves outcomes for cranial subdural empyemas: computed tomography-era experience with 699 patients.

2010-11-01T02:26:19Z

OBJECTIVE: Uncertainty regarding the best surgical management for subdural empyemas (SDEs) continues. Our unit has considered craniotomy the preferred method of surgical drainage for all cranial SDEs since 1988. We performed an analysis of our previously published, computed tomography-era, experience with 699 patients. METHODS: Two analyses of the database (1983-1997) were performed. First, analys...

N Nathoo, S S Nadvi, E Gouws, J R van Dellen (2001) Neurosurgery 49: 4 872-7; discussion 877-8

Neuroendoscopy--report of initial experience.

2010-11-01T02:26:19Z

N Nathoo, S T Govender, P V Govender, A Landers, N Dasi, P Corr (2001) S Afr Med J 91: 12 1046-1047

Cranial fasciitis. Case illustration.

2010-11-01T02:26:19Z

P V Govender, R Jithoo, V Chrystal, T Däuth, N Nathoo (2001) J Neurosurg 94: 4

Is skull radiography necessary for open scalp wounds in minor head injuries?

2010-11-01T02:24:18Z

H Boodhoo, N Nathoo (2001) S Afr J Surg 39: 3

Penetrating nail gun injury of the head and chest with incidental pericallosal artery aneurysm.

2010-11-01T02:26:19Z

R Jithoo, S T Govender, N Nathoo (2001) S Afr Med J 91: 4 316-317

The CRASH trial--the first large-scale randomised controlled trial in head injury.

2010-11-01T02:25:13Z

B Hartzenberg, N Nathoo (2001) S Afr Med J 91: 11

Longstanding retained foreign bodies in the cranium: a short case report.

2010-11-01T02:25:13Z

Two cases of longstanding retained cranial foreign bodies treated surgically are reported. Patients with longstanding retained foreign bodies may remain clinically well until complications arise. This report emphasizes the importance of maintaining clinical suspicion in mild head injured patients presenting with open scalp wounds, and the value of skull radiographs.

H Boodhoo, S S Nadvi, N Nathoo (2001) Cent Afr J Med 47: 7 182-184

Lumbar puncture is dangerous in patients with brain abscess or subdural empyema.

2010-11-01T02:26:19Z

S S Nadvi, N Nathoo, J R van Dellen (2000) S Afr Med J 90: 6 609-610

Role of cerebrospinal fluid shunting for human immunodeficiency virus-positive patients with tuberculous meningitis and hydrocephalus.

2010-11-01T02:26:19Z

OBJECTIVE: Tuberculous meningitis (TBM) and its complications continue to have devastating neurological consequences for patients. Budgetary constraints, especially in developing countries, have made it necessary to select patients for shunting who are likely to experience good recoveries. To date, the value of cerebrospinal fluid shunting for human immunodeficiency virus (HIV)-positive patients w...

S S Nadvi, N Nathoo, K Annamalai, J R van Dellen, A I Bhigjee (2000) Neurosurgery 47: 3 644-9; discussion 649-50

Spinal epidural abscess.

2010-11-01T02:26:19Z

P Corr, N Nathoo, A T Landers (2000) S Afr Med J 90: 8 779-780

Cerebral blood flow changes in rhinogenic subdural empyema and the role of hyperaemia in brain swelling.

2010-11-01T02:24:18Z

BACKGROUND: Previous studies have demonstrated that rhinogenic subdural empyema (SDE) generally has a good prognosis. Most patients are admitted with an altered level of consciousness or significant neurological deficit, but eventually have a good outcome. It is well known that intra-operative brain swelling may occur with subdural empyema. OBJECTIVE: To define cerebral blood flow (CBF) dynamics a...

N Nathoo, S S Nadvi, D Royston, J R van Dellen, M Rana, P K Narotam, E Gouws (2000) East Afr Med J 77: 7 359-363

Transcranial brainstem stab injuries: a retrospective analysis of 17 patients.

2010-11-01T02:26:19Z

OBJECTIVE: Transcranial stab injuries remain a frequent cause of emergent neurosurgical admissions to neurosurgical units in South Africa. Brainstem stabs are an uncommon, yet often fatal, form of brain injury. METHODS: A retrospective audit of 597 patients with transcranial stab injuries admitted to our unit over a 12-year period (January 1987 to December 1998) identified 17 patients (2.85%) with...

N Nathoo, H Boodhoo, S S Nadvi, S R Naidoo, E Gouws (2000) Neurosurgery 47: 5 1117-22; discussion 1123

Traumatic cranial empyemas: a review of 55 patients.

2010-11-01T02:26:19Z

A 15-year (1983-1997) review of our unit's computed tomographic experience with traumatic cranial empyema (TCE) is reported. Fifty-five patients with documented history and clinical evidence of neurotrauma with secondary cranial empyema at surgery were identified. The clinical records and CT scans were analysed. TCE [four extradural and 51 subdural collections (SDE)] accounted for 7.86% of the tot...

N Nathoo, S S Nadvi, J R Van Dellen (2000) Br J Neurosurg 14: 4 326-330

Cranial extradural empyema in the era of computed tomography: a review of 82 cases.

2010-11-01T02:27:41Z

OBJECTIVE: Intracranial suppurative disorders (abscesses and empyemas) continue to be common neurosurgical emergencies in South Africa. Cranial extradural empyema (EDE) occurs less frequently than its subdural counterpart but remains a potentially devastating disease process. We present our 15-year experience with this condition in the era of computed tomography. METHODS: Of the 4623 patients with...

N Nathoo, S S Nadvi, J R van Dellen (1999) Neurosurgery 44: 4 748-53; discussion 753-4

Intracranial subdural empyemas in the era of computed tomography: a review of 699 cases.

2010-11-01T02:27:41Z

OBJECTIVE: Intracranial empyemas are the most common form of intracranial suppuration seen in our unit and, despite modern antibiotic therapy and advanced neurosurgical and imaging facilities, these pus collections remain a formidable challenge, often resulting in significant morbidity and death. We present an analysis of our 15-year experience with this condition in the era of computed tomography...

N Nathoo, S S Nadvi, J R van Dellen, E Gouws (1999) Neurosurgery 44: 3 529-35; discussion 535-6

'Yes!' to telemedicine.

2010-11-01T02:27:41Z

R Jithoo, N Nathoo, P Corr (1999) S Afr Med J 89: 11

Cytokine expression in patients with treated congenital hydrocephalus: a preliminary report of five patients.

2010-11-01T02:26:19Z

BACKGROUND: Previous studies have described the elaboration of cytokines in experimental models of congenital hydrocephalus using rats or mice. However, there have been no reports of similar studies in humans. OBJECTIVE: To determine the cytokine expression pattern in the cerebrospinal fluid (CSF) of patients with treated congenital hydrocephalus. DESIGN: A prospective study. SETTING: Wentworth Ho...

S S Nadvi, K Annamalai, V L Naicker, U G Govender, N Nathoo, J R Van Dellen, A I Bhigjee (1999) East Afr Med J 76: 12 696-699

Traumatic intracranial aneurysms following penetrating stab wounds to the head: two unusual cases and review of the literature.

2010-11-01T02:27:41Z

Two patients with rare complications of traumatic intracranial aneurysms following penetrating cranial stab wounds are described. One patient had a good outcome despite a secondary rupture of a traumatic proximal middle cerebral artery aneurysm, while the second patient had a traumatic basilar bifurcation artery aneurysm. To our knowledge neither the survival from a secondary rupture of a traumati...

N Nathoo, S S Nadvi (1999) Cent Afr J Med 45: 8 213-217

Intracranial malposition of a nasogastric tube following repair of choanal atresia.

2010-11-01T02:27:41Z

Intracranial penetration during attempted nasogastric intubation is a rare, often lethal occurrence. We report the inadvertent introduction of a nasogastric tube intracranially in a neonate following repair of unilateral choanal atresia. Following manual removal of the tube, the patient made a good recovery.

N Nathoo, S S Nadvi (1999) Br J Neurosurg 13: 4 409-410

Intracranial tuberculous subdural empyema: case report.

2010-11-01T02:27:41Z

OBJECTIVE AND IMPORTANCE: Many types of neurotuberculosis have been described; the most common intracranial forms are tuberculous meningitis and tuberculomas. We report a unique and as yet unreported form of neurotuberculosis, which is an intracranial tuberculous subdural empyema. CLINICAL PRESENTATION: A 59-year-old man who had been previously treated for pulmonary tuberculosis (TB) presented at ...

A van Dellen, S S Nadvi, N Nathoo, P K Ramdial (1998) Neurosurgery 43: 2 370-373

Spontaneous drainage of an infratentorial extradural empyema: case report.

2010-11-01T02:27:41Z

We describe a 21-year-old male who presented with spontaneous drainage of an infratentorial extradural empyema secondary to mastoiditis. Following eradication of the primary source, the patient was commenced on high dose intravenous antibiotics. Serial computed tomography (CT) revealed complete resolution of the pus collection. Antibiotic therapy was successful and no neurosurgical intervention wa...

N Nathoo, S Nadvi, R van der Merwe (1997) Br J Neurosurg 11: 1 75-77

Infratentorial empyema: analysis of 22 cases.

2010-11-01T02:27:41Z

OBJECTIVE: Infratentorial empyema is an uncommon form of intracranial suppuration that is usually secondary to neglected otogenic infection. The diagnosis is frequently delayed and often confused with that of meningitis. The associated mortality is distressingly high, yet it has, as a clinical entity, received scant attention in the literature. We present a 13-year experience of this condition. PA...

N Nathoo, S S Nadvi, J R van Dellen (1997) Neurosurgery 41: 6 1263-8; discussion 1268-9