http://publicationslist.org/data/oliver.noga/atom.xml Oliver Nogahttp://publicationslist.org/oliver.noga$basepathfavicon.icoRecent additions to Oliver Noga's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-03-02T12:20:42Z http://publicationslist.org/oliver.noga/refid3 2008-03-02T12:09:08Z

BACKGROUND: Asthma is a chronic disease defined by airway inflammation, increased airway hyperresponsiveness and episodes of airway obstruction. Although there are abundant clinical and experimental data showing that stress may worsen asthma, the mechanisms linking stress to asthma are not well understood. By inducing a pro-inflammatory cytokine milieu, stress might enhance airway inflammation in ...<br/><br/>R A Joachim, O Noga, V Sagach, G Hanf, H Fliege, R D Kocalevent, E M Peters, B F Klapp (2008) <i>Clin Exp Allergy</i> <i></i> <i></i> 38: 2 283-290<br/>

http://publicationslist.org/oliver.noga/refid6 2008-02-03T09:55:03Z

BACKGROUND & OBJECTIVE: Because of environmental concerns CFC-containing pressurised metered dose inhalers (pMDI) had to be replaced by dry powder inhalers (DPI). The Novolizer((R)), a novel DPI has previously been shown to be as effective as the Turbuhaler((R)) in delivering budesonide. The objective of this study was to show non-inferiority of inhaled formoterol therapy delivered through the Nov...<br/><br/> Otto-Knapp, Conrad, Hösch, Metzenauer, Maus, Noga, Petzold, Kunkel (2008) <i>Pulm Pharmacol Ther</i> <i></i> <i></i> 21: 1 47-53<br/>

http://publicationslist.org/oliver.noga/refid1 2008-03-02T12:09:08Z

BACKGROUND: Neurotrophins are produced by various cells upon different stimuli and participate in the initiation and regulation of inflammation in various diseases including allergy and asthma, but little is known about the production and control of neurotrophins by dendritic cells (DCs). The aim of this study was to assess whether DCs produce the neurotrophins nerve growth factor (NGF) and brain-...<br/><br/>O Noga, M Peiser, M Altenähr, B Schmeck, R Wanner, Q T Dinh, G Hanf, N Suttorp (2008) <i>Clin Exp Allergy</i> <i></i> <i></i> 38: 3 473-479<br/>

http://publicationslist.org/oliver.noga/refid2 2008-03-02T12:09:08Z

Background: Omalizumab is an established add-on therapy efficacious in allergic diseases with additional anti-inflammatory activity in the treatment of asthma. The evaluation of responders to anti-IgE treatment is critical to maximize benefit/risk/cost ratio. The aim of the study was to monitor the efficacy of anti-IgE treatment by ex vivo basophil histamine release. Methods: Seventeen patients wi...<br/><br/> Noga, Hanf, Kunkel, Kleine-Tebbe (2007) <i>Int Arch Allergy Immunol</i> <i></i> <i></i> 146: 1 66-70<br/>

http://publicationslist.org/oliver.noga/refid5 2008-02-03T09:55:03Z

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a molecule influencing neuronal proliferation and differentiation. In states of allergy, it may orchestrate inflammatory changes by linking the immune system with the nervous system. Because the precise regulation of gene transcription in mast cells MCs is not clear, the present studies assessed the gene regulation of BDNF in this inflammator...<br/><br/>D A Groneberg, T C Fischer, N Peckenschneider, O Noga, Q T Dinh, T Welte, P Welker (2007) <i>Clin Exp Allergy</i> <i></i> <i></i> 37: 9 1386-1391<br/>

http://publicationslist.org/oliver.noga/refid4 2008-02-03T09:55:03Z

BACKGROUND: Neurotrophins are involved in inflammatory reactions influencing several cells in health and disease including allergy and asthma. Dendritic cells (DCs) play a major role in the induction of inflammatory processes with an increasing role in allergic diseases as well. OBJECTIVE: The aim of this study was to investigate the influence of neurotrophins on DC function. METHODS: Monocyte-der...<br/><br/>O Noga, M Peiser, M Altenähr, H Knieling, R Wanner, G Hanf, R Grosse, N Suttorp (2007) <i>Clin Exp Allergy</i> <i></i> <i></i> 37: 11 1701-1708<br/>

http://publicationslist.org/oliver.noga/refid8 2008-02-03T09:55:03Z

BACKGROUND: Omalizumab is a recombinant monoclonal anti-IgE antibody with proven efficacy in allergic diseases and further anti-inflammatory potency in the treatment of asthma. OBJECTIVES: To explore the anti-inflammatory mechanism of omalizumab, we investigated the induction of immunologic changes leading to eosinophil apoptosis and examined T-lymphocyte cytokine profiles in patients with allergi...<br/><br/>Oliver Noga, Gerald Hanf, Ilka Brachmann, Andrea C Klucken, Jörg Kleine-Tebbe, Simone Rosseau, Gert Kunkel, Norbert Suttorp, Joachim Seybold (2006) <i>J Allergy Clin Immunol</i> <i></i> <i></i> 117: 6 1493-1499<br/>

http://publicationslist.org/oliver.noga/refid7 2008-02-03T09:55:03Z

BACKGROUND: Omalizumab, a recombinant monoclonal anti-immunoglobulin E (IgE) antibody, shows proven efficacy in the treatment of allergic diseases. A little is known about the immunological pathways affected by the decrease of circulating free IgE during omalizumab treatment. AIM OF THE STUDY: To investigate the immunological consequence of IgE withdrawal, we studied the influence of omalizumab on...<br/><br/>G Hanf, I Brachmann, J Kleine-Tebbe, J Seybold, G Kunkel, N Suttorp, O Noga (2006) <i>Allergy</i> <i></i> <i></i> 61: 9 1141-1144<br/>

http://publicationslist.org/oliver.noga/refid10 2008-02-03T09:55:03Z

OBJECTIVE: Persistent perennial allergic rhinitis belongs to the most frequent diseases in occupational and environmental medicine. Because the innervation may play a role in the pathogenesis of the disease, the present study analyzed nasal mucosal nerve profiles. METHODS: Neuropeptide-containing nerve fibers were examined using immunohistochemistry and related to eosinophil and mast cell numbers....<br/><br/>Axel Fischer, Anke Wussow, Annette Cryer, Bernd Schmeck, Oliver Noga, Martina Zweng, Christian Peiser, Q Thai Dinh, Werner Heppt, David A Groneberg (2005) <i>J Occup Environ Med</i> <i></i> <i></i> 47: 1 20-25<br/>

http://publicationslist.org/oliver.noga/refid9 2008-02-03T09:55:03Z

BACKGROUND: Recent studies have shown that the neurotrophins NGF and BDNF are produced by eosinophils. The influence of neurotrophins in allergic diseases including asthma has been described. The regulation by pharmacological substance remains unclear. OBJECTIVES: The aim of this study was to assess whether approved pharmacological substances in the treatment of asthma such as corticosteroids or t...<br/><br/>Oliver Noga, Gerald Hanf, Dunja Görges, Q Thai Dinh, David A Groneberg, Norbert Suttorp, Gert Kunkel (2005) <i>Regul Pept</i> <i></i> <i></i> 132: 1-3 74-79<br/>

http://publicationslist.org/oliver.noga/refid22 2008-02-03T09:56:58Z

INTRODUCTION: Recent studies have shown that neurotrophins (NTs) are involved in inflammatory processes. Elevated plasma levels of NTs were found allergic diseases with the highest levels in allergic asthma. However, the exact cellular sources involved in the regulation and release of neurotrophins in allergic inflammation are still not well defined. OBJECTIVE: The aim of this study was to assess ...<br/><br/>Bettina Rost, Gerald Hanf, Ulrich Ohnemus, Ralf Otto-Knapp, David A Groneberg, Gert Kunkel, Oliver Noga (2005) <i>Regul Pept</i> <i></i> <i></i> 124: 1-3 19-25<br/>

http://publicationslist.org/oliver.noga/refid19 2008-02-03T09:56:58Z

Elevated serum levels of antigen-specific immunoglobulin (Ig)E are often associated with allergic respiratory diseases. This parallel-group, randomised, double-blind, placebo-controlled trial was designed to study the influence of omalizumab on the early nasal response to allergen challenge reflected by symptom score and inflammatory marker levels in nasal lavage fluid (NAL). A total of 23 patient...<br/><br/>G Hanf, O Noga, A O'Connor, G Kunkel (2004) <i>Eur Respir J</i> <i></i> <i></i> 23: 3 414-418<br/>

http://publicationslist.org/oliver.noga/refid21 2008-02-03T09:56:58Z

BACKGROUND: Allergic rhinitis (AR) is the most common allergic disease affecting the respiratory tract. Next to inflammatory changes, the airway innervation plays an important modulatory role in the pathogenesis of the disease. OBJECTIVE: To examine the participation of different neuropeptides in the human nasal mucosa of intermittent (seasonal) AR tissues in the allergic season. METHODS: Immunohi...<br/><br/>W Heppt, Q Thai Dinh, A Cryer, M Zweng, O Noga, C Peiser, M Melvan, C Witt, A Fischer, D A Groneberg (2004) <i>Clin Exp Allergy</i> <i></i> <i></i> 34: 7 1105-1110<br/>

http://publicationslist.org/oliver.noga/refid18 2008-02-03T09:56:58Z

BACKGROUND/OBJECTIVES: The mechanical aerosol generator, MAGhaler, is a new chlorofluorocarbon-free inhalation device. The objective of this trial was to show equivalent efficacy and safety of beclomethasone dipropionate (BDP) delivered via the MAGhaler and the metered-dose inhaler (MDI) in patients with mild to moderate bronchial asthma. Moreover, user-friendliness and acceptance of the two devic...<br/><br/>G Kunkel, C Schäper, O Noga, S Schläfke, G Lemmnitz, S Köhler (2003) <i>Respiration</i> <i></i> <i></i> 70: 4 399-406<br/>

http://publicationslist.org/oliver.noga/refid17 2008-02-03T09:56:58Z

IgE plays a key role in allergic asthma. We investigated whether omalizumab treatment of patients with moderate to severe allergic asthma leads to changes in inflammatory mediators and clinical symptoms. This sub-study was conducted on 35 patients with a positive skin prick test (SPT) requiring daily administration of beclomethasone dipropionate (500-1,000 microg), who participated in a multicentr...<br/><br/>Oliver Noga, Gerald Hanf, Gert Kunkel (2003) <i>Int Arch Allergy Immunol</i> <i></i> <i></i> 131: 1 46-52<br/>

http://publicationslist.org/oliver.noga/refid16 2008-02-03T09:56:58Z

BACKGROUND: Recent studies have shown that neurotrophins are produced by and can act on several immune-inflammatory cells. The origin of circulating as well as local neurotrophins is unknown. OBJECTIVES: The aim of this study was to assess whether eosinophils of allergic and non-allergic donors produce, store and release the neurotrophic factors NGF, BDNF and NT-3. METHODS: Eosinophils were purifi...<br/><br/>O Noga, C Englmann, G Hanf, A Grützkau, J Seybold, G Kunkel (2003) <i>Clin Exp Allergy</i> <i></i> <i></i> 33: 5 649-654<br/>

http://publicationslist.org/oliver.noga/refid15 2008-02-03T09:56:58Z

BACKGROUND: Recent studies have shown that nerve growth factor (NGF) can act on several immune cells as well as residential cells. But little is known about their role in modulating eosinophil function via activation of high-affinity receptors. OBJECTIVES: The aim of this study was to assess whether eosinophils express functional receptors and if their function is influenced by NGF, brain-derived ...<br/><br/>O Noga, C Englmann, G Hanf, A Grützkau, S Guhl, G Kunkel (2002) <i>Clin Exp Allergy</i> <i></i> <i></i> 32: 9 1348-1354<br/>

http://publicationslist.org/oliver.noga/refid14 2008-02-03T09:56:58Z

The ability of omalizumab, an anti-immnoglobulin-E agent, to maintain long-term disease control in patients with moderate-to-severe allergic asthma was investigated in a 24-week double-blind extension to a 28-week core trial. During the extension, 483 of the initial 546 patients were maintained on randomised treatment and the lowest sustainable dose of beclomethasone dipropionate (BDP) as establis...<br/><br/>R Buhl, M Solèr, J Matz, R Townley, J O'Brien, O Noga, K Champain, H Fox, J Thirlwell, G Della Cioppa (2002) <i>Eur Respir J</i> <i></i> <i></i> 20: 1 73-78<br/>

http://publicationslist.org/oliver.noga/refid13 2008-02-03T09:56:58Z

BACKGROUND: The neurotrophins Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin (NT)-3 are produced, stored and released by various immunological cells. The influence of NTs upon the function of these cells is described. Elevated plasma levels were found in inflammatory, autoimmune and allergic diseases with the highest levels in allergic asthma. A connection bet...<br/><br/>O Noga, G Hanf, C Schäper, A O'Connor, G Kunkel (2001) <i>Clin Exp Allergy</i> <i></i> <i></i> 31: 12 1906-1912<br/>

http://publicationslist.org/oliver.noga/refid12 2008-02-03T09:56:58Z

OBJECTIVE AND DESIGN: There is evidence that substance P (SP) is involved in events related to allergic and nonallergic rhinitis. Furthermore, some effects of SP seem to be greater in subjects suffering from allergic rhinitis than in nonallergic subjects. To investigate if these effects may be partly mediated by histamine release (HR) we studied the influence of SP on HR from nasal mucosa of subje...<br/><br/>G Hanf, K Schierhorn, T Brunnée, O Noga, D Verges, G Kunkel (2000) <i>Inflamm Res</i> <i></i> <i></i> 49: 10 520-523<br/>

http://publicationslist.org/oliver.noga/refid11 2008-02-03T09:56:58Z

BACKGROUND: In a recent study mast cell heparin proteoglycan (HepPG) of a cell line derived from a mouse mastocytoma was isolated. Glycosaminoglycans proved to be an initiating surface for starting contact activation and could explain kinin generation present in allergic reactions. It is the aim of the present study to prove that HepPG or glycosaminoglycan derived from human mast cells is also cap...<br/><br/>O Noga, T Brunnée, C Schäper, G Kunkel (1999) <i>Int Arch Allergy Immunol</i> <i></i> <i></i> 120: 4 310-316<br/>