http://publicationslist.org/data/oscar.braun/atom.xml Oscar Braunhttp://publicationslist.org/oscar.braun$basepathfavicon.icoRecent additions to Oscar Braun's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-05-23T05:49:49Z http://publicationslist.org/oscar.braun/refid16 2009-05-23T05:49:10Z

Aims The metabolic pathways leading to the formation of prasugrel and clopidogrel active metabolites differ. We hypothesized that decreased CYP2C19 activity affects the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. Methods and results Ninety-eight patients with coronary artery disease (CAD) taking either clopidogrel 600 mg loading dose (LD)/75 mg maintenance dose (...<br/><br/> Varenhorst, James, Erlinge, Brandt, Braun, Man, Siegbahn, Walker, Wallentin, Winters, Close (2009) <i>Eur Heart J</i> <i></i> <i></i> : <br/>

http://publicationslist.org/oscar.braun/refid14 2009-03-25T04:27:08Z

ABSTRACT: BACKGROUND: Mild hypothermia is currently standard of care for cardiac arrest patients in many hospitals and a common belief is that hypothermia attenuates platelet aggregation. We wanted to examine the effects of clopidogrel on platelet aggregation during hypothermia. METHODS: Platelet reactivity at 37 degrees C and 33 degrees C was evaluated by light transmission aggregometry and vasod...<br/><br/>Carl Högberg, David Erlinge, Oscar O Braun (2009) <i>Thromb J</i> <i></i> <i></i> 7: <br/>

http://publicationslist.org/oscar.braun/refid13 2009-05-23T05:49:10Z

BACKGROUND: Variability in response to thienopyridines has led to the development of point-of-care devices to assess adenosine diphosphate (ADP)-induced platelet aggregation. These tests need to be evaluated in comparison to reference measurements of P2Y(12) function during different thienopyridine treatments. METHODS: After a run-in on 75 mg aspirin, 110 subjects were randomized to double-blind t...<br/><br/>Christoph Varenhorst, Stefan James, David Erlinge, Oscar O Braun, John T Brandt, Kenneth J Winters, Joseph A Jakubowski, Sylvia Olofsson, Lars Wallentin, Agneta Siegbahn (2009) <i>Am Heart J</i> <i></i> <i></i> 157: 3 562.e1-562.e9<br/>

http://publicationslist.org/oscar.braun/refid15 2009-05-23T05:49:10Z

OBJECTIVE: Recent findings indicate that platelets not only regulate thrombosis and hemostasis but may also be involved in proinflammatory activities. Herein, we hypothesized that platelets may play a role in sepsis by activating and priming circulating neutrophils for subsequent recruitment into the lung. DESIGN: Prospective experimental study. SETTING: University Hospital Research Unit. SUBJECT:...<br/><br/>Muhammad Asaduzzaman, Shahram Lavasani, Milladur Rahman, Su Zhang, Oscar O Braun, Bengt Jeppsson, Henrik Thorlacius (2009) <i>Crit Care Med</i> <i></i> <i></i> 37: 4 1389-1396<br/>

http://publicationslist.org/oscar.braun/refid7 2009-02-05T17:13:23Z

AIMS: P2Y(12) receptor antagonism and platelet inhibition by prasugrel vs. clopidogrel were investigated in patients with stable coronary artery disease. METHODS AND RESULTS: One hundred and ten aspirin treated subjects were randomized to double-blind treatment with clopidogrel (n = 55) 600 mg loading dose (LD) and 75 mg maintenance dose (MD) or prasugrel (n = 55) 60 mg LD and 10 mg MD for 28 days...<br/><br/>Lars Wallentin, Christoph Varenhorst, Stefan James, David Erlinge, Oscar O Braun, Joseph A Jakubowski, Atsuhiro Sugidachi, Kenneth J Winters, Agneta Siegbahn (2008) <i>Eur Heart J</i> <i></i> <i></i> 29: 1 21-30<br/>

http://publicationslist.org/oscar.braun/refid6 2009-02-05T17:13:23Z

BACKGROUND AND AIMS: The aims of this study were to investigate (1) if P2Y(12) polymorphisms defining the P2Y(12) H2 allele are associated with any other SNPs that may explain the previously reported association with increased ADP induced platelet activation and association with peripheral arterial disease and coronary artery disease and (2) if such variants are associated with acute myocardial in...<br/><br/>Stefan Amisten, Oscar O Braun, Lovisa Johansson, Martin Ridderstråle, Olle Melander, David Erlinge (2008) <i>PLoS ONE</i> <i></i> <i></i> 3: 1 <br/>

http://publicationslist.org/oscar.braun/refid5 2009-02-05T17:13:23Z

BACKGROUND: Platelet-endothelial cell interactions play a key role in hemostasis and pathological coagulation and are dependent on different surface molecules that are expressed upon activation (eg, mediated by lipopolysaccharide [LPS]). Recently, we have shown that Rho kinase plays a central role in LPS-mediated leukocyte-endothelial cell interactions. We investigated the role of Rho-kinase in in...<br/><br/>Jan E Slotta, Oscar O Braun, Michael D Menger, Henrik Thorlacius (2008) <i>J Investig Med</i> <i></i> <i></i> 56: 4 720-725<br/>

http://publicationslist.org/oscar.braun/refid8 2009-02-05T17:13:23Z

INTRODUCTION AND MATERIALS AND METHODS: G-protein coupled receptors (GPCRs) play an important role in platelet aggregation. To identify new platelet GPCRs, a platelet gene expression profile was generated and validated using quantitative real-time PCR. RESULTS: In total, mRNA of 28 GPCR genes was detected in human platelets. The 12 most abundant platelet GPCR transcripts were: thrombin receptor PA...<br/><br/>Stefan Amisten, Oscar O Braun, Anders Bengtsson, David Erlinge (2008) <i>Thromb Res</i> <i></i> <i></i> 122: 1 47-57<br/>

http://publicationslist.org/oscar.braun/refid2 2009-02-05T17:13:23Z

Prasugrel, a novel P2Y(12) ADP-receptor antagonist, has been reported to achieve greater inhibition of platelet aggregation compared to clopidogrel as assessed by light transmission aggregometry. It was the objective of this study to investigate the effect of prasugrel on alternative markers of platelet activation in comparison to a high loading dose and the approved maintenance dose of clopidogre...<br/><br/>Oscar O Braun, Matilda Johnell, Christoph Varenhorst, Stefan James, John T Brandt, Joseph A Jakubowski, Kenneth J Winters, Lars Wallentin, David Erlinge, Agneta Siegbahn (2008) <i>Thromb Haemost</i> <i></i> <i></i> 100: 4 626-633<br/>

http://publicationslist.org/oscar.braun/refid3 2009-02-05T17:13:23Z

Platelets constitute a key role in vascular injuries, however, the detailed mechanisms behind platelet-endothelial cell and platelet-leukocyte interactions in the femoral artery are not yet fully elucidated. We used intravital fluorescence microscopy of the femoral artery in C57BL/6 mice to study primary and secondary capture of platelets onto endothelial cells as well as onto adherent platelets a...<br/><br/>Oscar O Braun, Jan E Slotta, Michael D Menger, David Erlinge, Henrik Thorlacius (2008) <i>Eur J Pharmacol</i> <i></i> <i></i> 592: 1-3 128-132<br/>

http://publicationslist.org/oscar.braun/refid1 2009-02-05T17:13:23Z

OBJECTIVES: We evaluated the prevalence and mechanism of poor responsiveness to clopidogrel and prasugrel in coronary artery disease patients with and without diabetes. BACKGROUND: Low platelet inhibition by clopidogrel is associated with ischemic clinical events. A higher 600-mg loading dose (LD) has been advocated to increase responsiveness to clopidogrel. METHODS: In this study, 110 aspirin-tre...<br/><br/>David Erlinge, Christoph Varenhorst, Oscar O Braun, Stefan James, Kenneth J Winters, Joseph A Jakubowski, John T Brandt, Atsuhiro Sugidachi, Agneta Siegbahn, Lars Wallentin (2008) <i>J Am Coll Cardiol</i> <i></i> <i></i> 52: 24 1968-1977<br/>

http://publicationslist.org/oscar.braun/refid4 2009-02-05T17:13:23Z

Two ADP receptors have been identified on human platelets: P2Y(1) and P2Y(12). The P2Y(12) receptor blocker clopidogrel is widely used to reduce the risks in acute coronary syndromes, but, currently, there is no P2Y(1) blocker in clinical use. Evidence for variable responses to clopidogrel has been described in several reports. The mechanistic explanation for this phenomenon is not fully understoo...<br/><br/>Oscar O Braun, Stefan Amisten, Anna-Karin Wihlborg, Karen Hunting, David Nilsson, David Erlinge (2007) <i>Purinergic Signal</i> <i></i> <i></i> 3: 3 195-201<br/>

http://publicationslist.org/oscar.braun/refid9 2009-02-05T17:13:23Z

OBJECTIVE AND DESIGN: Emerging data suggest that Rho-kinase signaling may regulate numerous aspects of inflammatory reactions. Herein, we investigated the role of Rho-kinase in inflammatory interactions between leukocytes and the endothelium in femoral arteries and veins in vivo. MATERIAL AND METHODS: Mice were injected with lipopolysaccharide (LPS) and Rho-kinase was inhibited by pre-treatment wi...<br/><br/>J E Slotta, O O Braun, M D Menger, H Thorlacius (2006) <i>Inflamm Res</i> <i></i> <i></i> 55: 9 364-367<br/>

http://publicationslist.org/oscar.braun/refid10 2009-02-05T17:13:23Z

Peripheral arterial disease (PAD) is associated with platelet hyperaggregability as well as an increase in morbidity and mortality from myocardial infarction (MI) and stroke. Purinergic signaling has been shown, both experimentally and clinically, to play an important role in the activation of platelets. Platelets express three different purinergic receptors: P2Y1, P2Y12 and P2X1. We assessed the ...<br/><br/>Oscar O Braun, Anita Jagroop, Lingwei Wang, Dimitri P Mikhailidis, Geoffrey Burnstock, David Erlinge (2005) <i>Platelets</i> <i></i> <i></i> 16: 5 261-267<br/>

http://publicationslist.org/oscar.braun/refid11 2009-02-05T17:13:23Z

OBJECTIVE: ADP plays an important role in platelet aggregation by activating P2Y12 receptors. We assessed the hypothesis that P2Y12 receptors are expressed in vascular smooth muscle cells (VSMC). METHODS AND RESULTS: P2Y12 receptor mRNA was found to have a high expression among the P2 receptors in human VSMC, significantly higher than the other 2 ADP receptors (P2Y1 and P2Y13, real-time polymerase...<br/><br/>Anna-Karin Wihlborg, Lingwei Wang, Oscar Ostberg Braun, Atli Eyjolfsson, Ronny Gustafsson, Tomas Gudbjartsson, David Erlinge (2004) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 24: 10 1810-1815<br/>

http://publicationslist.org/oscar.braun/refid12 2009-02-05T17:14:09Z

The mechanism of ADP-mediated platelet activation has been difficult to unravel due to the large number of receptors for extracellular nucleotides (P2 receptors). mRNA levels in circulating platelets are very low, but have been shown to be translationally active. By optimizing mRNA extraction and using real time (RT)-PCR we were able to establish a protocol for highly sensitive platelet mRNA quant...<br/><br/>L Wang, O Ostberg, A-K Wihlborg, H Brogren, S Jern, D Erlinge (2003) <i>J Thromb Haemost</i> 1: 2 330-336<br/>