http://publicationslist.org/data/remy.durand/atom.xml Rémy DURANDhttp://publicationslist.org/remy.durand$basepathfavicon.icoRecent additions to Rémy DURAND's PublicationsList.org pagehttp://publicationslist.org/publications.png2016-05-12T08:22:51Z http://publicationslist.org/remy.durand/refid58 2016-05-11T08:58:41Z

Scabies, or mange as it is called in animals, is an ectoparasitic contagious infestation caused by the mite Sarcoptes scabiei. Sarcoptic mange is an important veterinary disease leading to significant morbidity and mortality in wild and domestic animals. A widely accepted hypothesis, though never substantiated by factual data, suggests that humans were the initial source of the animal contaminatio...<br/><br/>Valérie Andriantsoanirina, Fang Fang, Frédéric Ariey, Arezki Izri, Françoise Foulet, Françoise Botterel, Charlotte Bernigaud, Olivier Chosidow, Weiyi Huang, Jacques Guillot, Rémy Durand (2016) <i>Parasites & vectors</i> <i></i> <i></i> 9: 1 <br/>

http://publicationslist.org/remy.durand/refid61 2016-05-11T08:58:41Z

Arezki Izri, Valérie Andriantsoanirina, Olivier Chosidow, Rémy Durand (2015) <i>JAMA dermatology</i> <i></i> <i></i> 151: 8 909-910<br/>

http://publicationslist.org/remy.durand/refid62 2016-05-11T08:58:41Z

According to previous studies, Sarcoptes mites of wombats were relatively recently introduced into Australia by colonizers and/or their dogs. However, that affirmation has been called into question due to apparent flaws in the design of the phylogenetic studies. With the aim of providing a definitive answer to this question, a part of the mitochondrial gene coding for 12S rRNA of S. scabiei mites ...<br/><br/>V Andriantsoanirina, F Ariey, A Izri, C Bernigaud, F Fang, J Guillot, O Chosidow, R Durand (2015) <i>Parasitology research</i> <i></i> <i></i> 114: 6 2079-2083<br/>

http://publicationslist.org/remy.durand/refid88 2016-05-12T08:16:02Z

The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair the detection and assignment to one or another protein of some pathogenic processes inherent to Plasmodium falciparum malaria. The present study was intended to determine if the antibody and inflammatory responses of children living in a malaria-endemic area varied...<br/><br/>Cyril Badaut, Léa Guyonnet, Jacqueline Milet, Emmanuelle Renard, Rémy Durand, Firmine Viwami, Gratien Sagbo, Francis Layla, Philippe Deloron, Serge Bonnefoy, Florence Migot-Nabias (2015) <i>Malaria journal</i> <i></i> <i></i> 14: <br/>

http://publicationslist.org/remy.durand/refid60 2016-05-11T08:58:41Z

Sarcoptes scabiei infection is a contagious disease affecting both humans and animals. The transmission occurs either by direct contact or from the environment where mites could survive several days remaining infective. The number of products available for environmental control of S. scabiei is very limited. The objective of the present study was to assess the efficacy of biocides or repellents ag...<br/><br/>Fang Fang, Charlotte Bernigaud, Kerdalidec Candy, Elise Melloul, Arezki Izri, Rémy Durand, Françoise Botterel, Olivier Chosidow, Weiyi Huang, Jacques Guillot (2015) <i>Parasites & vectors</i> <i></i> <i></i> 8: <br/>

http://publicationslist.org/remy.durand/refid87 2016-05-12T08:14:54Z

Doxycycline is an antibiotic used in combination with quinine or artesunate for malaria treatment or alone for malaria chemoprophylaxis. Recently, one prophylactic failure has been reported, and several studies have highlighted in vitro doxycycline decreased susceptibility in Plasmodium falciparum isolates from different areas. The genetic markers that contribute to detecting and monitoring the su...<br/><br/>Tiphaine Gaillard, Nathalie Wurtz, Sandrine Houzé, Kanlaya Sriprawat, Chirapat Wangsing, Véronique Hubert, Jacques Lebras, François Nosten, Sébastien Briolant, Bruno Pradines, (2015) <i>Malaria journal</i> <i></i> <i></i> 14: <br/>

http://publicationslist.org/remy.durand/refid59 2016-05-11T08:58:41Z

Scabies is an ectoparasitic infestation caused by the mite Sarcoptes scabiei. Currently, S. scabiei is taxonomically divided into different varieties on the basis of host origin. Genetics-based research on scabies has been conducted, but the data on genetic diversity of populations of this mite in humans in Europe are lacking. We evaluated the genetic diversity of populations of S. scabiei. A la...<br/><br/>V Andriantsoanirina, F Ariey, A Izri, C Bernigaud, F Fang, R Charrel, F Foulet, F Botterel, J Guillot, O Chosidow, R Durand (2015) <i>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</i> <i></i> <i></i> 21: 12 1107-1114<br/>

http://publicationslist.org/remy.durand/refid67 2016-05-11T08:58:41Z

There are growing concerns about the emergence of resistance of Sarcoptes scabiei to permethrin and other pyrethroid derivatives. Sarcoptes scabiei mites collected from 40 patients visiting two hospitals near Paris, France, were genotypically characterized considering two parts of their voltage-sensitive sodium channel gene. No nucleotide polymorphism resulting in a codon change at codon 733 or ot...<br/><br/>V Andriantsoanirina, A Izri, F Botterel, F Foulet, O Chosidow, R Durand (2014) <i>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</i> <i></i> <i></i> 20: 2 O139-O141<br/>

http://publicationslist.org/remy.durand/refid64 2016-05-11T08:58:41Z

Arezki Izri, Amina Bendjaballah, Valérie Andriantsoanirina, Rémy Durand (2014) <i>Emerging infectious diseases</i> <i></i> <i></i> 20: 3 502-504<br/>

http://publicationslist.org/remy.durand/refid63 2016-05-11T08:58:41Z

Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infection triggered by P. falciparum infections expose ...<br/><br/>Nimol Khim, Voahangy Andrianaranjaka, Jean Popovici, Saorin Kim, Arsene Ratsimbasoa, Christophe Benedet, Celine Barnadas, Remy Durand, Marc Thellier, Eric Legrand, Lise Musset, Michela Menegon, Carlo Severini, Bakri Y M Nour, Magali Tichit, Christiane Bouchier, Odile Mercereau-Puijalon, Didier Ménard (2014) <i>Emerging infectious diseases</i> <i></i> <i></i> 20: 10 1637-1644<br/>

http://publicationslist.org/remy.durand/refid68 2016-05-11T08:58:41Z

Chloroquine (CQ) was the main malaria therapy worldwide from the 1940s until the 1990s. Following the emergence of CQ-resistant Plasmodium falciparum, most African countries discontinued the use of CQ, and now promote artemisinin-based combination therapy as the first-line treatment. This change was generally initiated during the last decade in West and Central Africa. The aim of this study is to ...<br/><br/>Myriam Gharbi, Jennifer A Flegg, Véronique Hubert, Eric Kendjo, Jessica E Metcalf, Lionel Bertaux, Philippe J Guérin, Jacques Le Bras, , Ahmed Aboubaca, Patrice Agnamey, Adela Angoulvant, Patricia Barbut, Didier Basset, Ghania Belkadi, Anne Pauline Bellanger, Dieudonné Bemba, Françoise Benoit-Vica, Antoine Berry, Marie-Laure Bigel, Julie Bonhomme, Françoise Botterel, Olivier Bouchaud, Marie-Elisabeth Bougnoux, Patrice Bourée, Nathalie Bourgeois, Catherine Branger, Laurent Bret, Bernadette Buret, Enrique Casalino, Sylviane Chevrier, Frédérique Conquere de Monbrison, Bernadette Cuisenier, Martin Danis, Marie-Laure Darde, Ludovic De Gentile, Jean-Marie Delarbre, Pascal Delaunay, Anne Delaval, Guillaume Desoubeaux, Michel Develoux, Jean Dunand, Rémy Durand, Odile Eloy, Nathalie Fauchet, Bernard Faugere, Alber Faye, Odile Fenneteau, Pierre Flori, Madeleine Fontrouge, Chantal Garabedian, Françoise Gayandrieu, Nadine Godineau, Pascal Houzé, Sandrine Houzé, Jean-Pierre Hurst, Houria Ichou, Laurence Lachaud, Agathe Lebuisson, Magalie Lefevre, Anne-Sophie LeGuern, Gwenaë Le Moal, Daniel Lusina, Marie-Claude Machouart, Denis Malvy, Sophie Matheron, Danièle Maubon, Denis Mechali, Bruno Megarbane, Guillaume Menard, Laurence Millon, Muriel Mimoun Aiach, Philippe Minodier, Christelle Morelle, Gilles Nevez, Philippe Parola, Daniel Parzy, Olivier Patey, Pierre Patoz, Pascale Penn, Alice Perignon, Stéphane Picot, Jean-Etienne Pilo, Isabelle Poilane, Denis Pons, Marie Poupart, Bruno Pradines, Didier Raffenot, Christophe Rapp, Marie-Catherine Receveur, Claudine Sarfati, Yaye Senghor, Fabrice Simon, Jean-Yves Siriez, Nicolas Taudon, Marc Thellier, Maxime Thouvenin, Dominique Toubas (2013) <i>Malaria journal</i> <i></i> <i></i> 12: <br/>

http://publicationslist.org/remy.durand/refid69 2016-05-11T08:58:41Z

To date, 11 studies conducted in different countries to test the association between Plasmodium falciparum Na(+)/H(+) exchanger gene (pfnhe-1; PF13_0019) polymorphisms and in vitro susceptibility to quinine have generated conflicting data. In this context and to extend our knowledge of the genetic polymorphism of Pfnhe gene, we have sequenced the ms4760 locus from 595 isolates collected in the Com...<br/><br/>Valérie Andriantsoanirina, Nimol Khim, Arsene Ratsimbasoa, Benoit Witkowski, Christophe Benedet, Lydie Canier, Christiane Bouchier, Magali Tichit, Rémy Durand, Didier Ménard (2013) <i>The American journal of tropical medicine and hygiene</i> <i></i> <i></i> 88: 1 37-42<br/>

http://publicationslist.org/remy.durand/refid78 2016-05-11T10:30:03Z

The objective of this study was to evaluate the distribution of a series of independent doxycycline inhibitory concentration 50% (IC50) values to validate the trimodal distribution previously described and to validate the use of the pftetQ and pfmdt genes as molecular markers of decreased in vitro doxycycline susceptibility in Plasmodium falciparum malaria.<br/><br/>Tiphaine Gaillard, Sébastien Briolant, Sandrine Houzé, Meïli Baragatti, Nathalie Wurtz, Véronique Hubert, Morgane Lavina, Aurélie Pascual, Christelle Travaillé, Jacques Le Bras, Bruno Pradines, (2013) <i>Malaria journal</i> <i></i> <i></i> 12: <br/>

http://publicationslist.org/remy.durand/refid66 2016-05-11T08:58:41Z

Plasmodium vivax is the most prevalent human malaria parasite, causing serious public health problems in malaria-endemic countries. Until recently the Duffy-negative blood group phenotype was considered to confer resistance to vivax malaria for most African ethnicities. We and others have reported that P. vivax strains in African countries from Madagascar to Mauritania display capacity to cause cl...<br/><br/>Didier Menard, Ernest R Chan, Christophe Benedet, Arsène Ratsimbasoa, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski, Remy Durand, Marc Thellier, Carlo Severini, Eric Legrand, Lise Musset, Bakri Y M Nour, Odile Mercereau-Puijalon, David Serre, Peter A Zimmerman (2013) <i>PLoS neglected tropical diseases</i> <i></i> <i></i> 7: 11 <br/>

http://publicationslist.org/remy.durand/refid65 2016-05-11T08:58:41Z

The aim of this study was to provide a comprehensive analysis of the worldwide genetic polymorphism of ms4760 alleles of the pfnhe-1 gene and to discuss their usefulness as molecular marker of quinine resistance (QNR). A new numbering of ms4760 allele, classification grouping ms4760 alleles according to the number of DNNND and DDNHNDNHNND repeat motifs in blocks II and V was also proposed. A total...<br/><br/>Didier Ménard, Valérie Andriantsoanirina, Nimol Khim, Arsène Ratsimbasoa, Benoit Witkowski, Christophe Benedet, Lydie Canier, Odile Mercereau-Puijalon, Rémy Durand (2013) <i>International journal for parasitology. Drugs and drug resistance</i> <i></i> <i></i> 3: 8-19<br/>

http://publicationslist.org/remy.durand/refid70 2016-05-11T08:58:41Z

Bed bugs are hematophagous insects responsible for a re-emerging and challenging indoor pest in many countries. Bed bugs infestations may have health consequences including nuisance biting, cutaneous and systemic reactions. This resurgence can probably be attributed to factors such as increased international travel and development of resistance against insecticides. Resistance against pyrethroids ...<br/><br/>R Durand, A Cannet, Z Berdjane, C Bruel, D Haouchine, P Delaunay, A Izri (2012) <i>Parasite (Paris, France)</i> <i></i> <i></i> 19: 4 381-387<br/>

http://publicationslist.org/remy.durand/refid71 2016-05-11T08:58:41Z

Treatment of head lice infestation relies on the application of topical insecticides. Overuse of these products has led to the emergence of resistance to pyrethroids and malathion worldwide. Permethrin resistance in head lice is mostly conferred by the knockdown resistance (kdr) trait.<br/><br/>Sophie Bouvresse, Zohra Berdjane, Rémy Durand, Julie Bouscaillou, Arezki Izri, Olivier Chosidow (2012) <i>Journal of the American Academy of Dermatology</i> <i></i> <i></i> 67: 6 1143-1150<br/>

http://publicationslist.org/remy.durand/refid73 2016-05-11T08:58:41Z

Insecticide treatment resistance is considered to be a major factor in the increasing number of infestations by head lice. The large insecticide selection pressure induced by conventional topical pediculicides has led to the emergence and spread of resistance in many parts of the world. Possible mechanisms of resistance include accelerated detoxification of insecticides by enzyme-mediated reductio...<br/><br/>R Durand, S Bouvresse, Z Berdjane, A Izri, O Chosidow, J M Clark (2012) <i>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</i> <i></i> <i></i> 18: 4 338-344<br/>

http://publicationslist.org/remy.durand/refid72 2016-05-11T08:58:41Z

Plasmodium falciparum exports proteins that remodel the erythrocyte membrane. One such protein, called Pf155/RESA (RESA1) contributes to parasite fitness, optimizing parasite survival during febrile episodes. Resa1 gene is a member of a small family comprising three highly related genes. Preliminary evidence led to a search for clues indicating the involvement of RESA2 protein in the pathophysiolo...<br/><br/>Rémy Durand, Florence Migot-Nabias, Valérie Andriantsoanirina, Elise Seringe, Firmine Viwami, Gratien Sagbo, Francis Lalya, Philippe Deloron, Odile Mercereau-Puijalon, Serge Bonnefoy (2012) <i>Malaria journal</i> <i></i> <i></i> 11: <br/>

http://publicationslist.org/remy.durand/refid74 2016-05-11T08:58:41Z

Molecular investigations performed following the emergence of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum have allowed the identification of the dihydrofolate reductase (DHFR) enzyme as the target of pyrimethamine. Although clinical cases of Plasmodium malariae are not usually treated with antifolate therapy, incorrect diagnosis and the high frequency of undetected mixed inf...<br/><br/>Nimol Khim, Saorin Kim, Christiane Bouchier, Magali Tichit, Frédéric Ariey, Thierry Fandeur, Pheaktra Chim, Sopheakvatey Ke, Sarorn Sum, Somnang Man, Arsène Ratsimbasoa, Rémy Durand, Didier Ménard (2012) <i>Antimicrobial agents and chemotherapy</i> <i></i> <i></i> 56: 2 863-868<br/>

http://publicationslist.org/remy.durand/refid79 2016-05-11T10:13:33Z

We investigated chloroquine sensitivity to Plasmodium falciparum in travelers returning to France and Canada from Haiti during a 23-year period. Two of 19 isolates obtained after the 2010 earthquake showed mixed pfcrt 76K+T genotype and high 50% inhibitory concentration. Physicians treating malaria acquired in Haiti should be aware of possible chloroquine resistance.<br/><br/>Myriam Gharbi, Dylan R Pillai, Rachel Lau, Véronique Hubert, Krishna Khairnar, Alexandre Existe, Eric Kendjo, Sabina Dahlström, Philippe J Guérin, Jacques Le Bras, (2012) <i>Emerging infectious diseases</i> <i></i> <i></i> 18: 8 1346-1349<br/>

http://publicationslist.org/remy.durand/refid75 2016-05-11T08:58:41Z

The human body louse is the only known vector of Bartonella quintana. However, the presence of this bacterium has recently been detected in the head lice of homeless individuals and Nepalese slum children. Previous studies have reported the isolation of Acinetobacter baumannii from the body lice of homeless individuals. An epidemiological survey including 74 schools was conducted between 2008 and ...<br/><br/>Sophie Bouvresse, Cristina Socolovshi, Zohra Berdjane, Rémy Durand, Arezki Izri, Didier Raoult, Olivier Chosidow, Philippe Brouqui (2011) <i>Comparative immunology, microbiology and infectious diseases</i> <i></i> <i></i> 34: 6 475-477<br/>

http://publicationslist.org/remy.durand/refid2 2016-05-11T08:58:41Z

Little is known about severe imported Plasmodium falciparum malaria in industrialized countries where the disease is not endemic because most studies have been case reports or have included <200 patients. To identify factors independently associated with the severity of P. falciparum, we conducted a retrospective study using surveillance data obtained from 21,888 P. falciparum patients in France d...<br/><br/>Elise Seringe, Marc Thellier, Arnaud Fontanet, Fabrice Legros, Olivier Bouchaud, Thierry Ancelle, Eric Kendjo, Sandrine Houze, Jacques Le Bras, Martin Danis, Rémy Durand, (2011) <i>Emerging infectious diseases</i> <i></i> <i></i> 17: 5 807-813<br/>

http://publicationslist.org/remy.durand/refid1 2016-05-11T08:58:41Z

Virginie Prendki, Pierre Fenaux, Rémy Durand, Marc Thellier, Olivier Bouchaud (2011) <i>Emerging infectious diseases</i> <i></i> <i></i> 17: 5 931-932<br/>

http://publicationslist.org/remy.durand/refid77 2016-05-11T08:58:41Z

The purpose of this review was to provide up-to-date information on the resistance of Plasmodium falciparum to the main antimalarials used in Madagascar and to assist implementation of the malaria control and elimination program. In 2006, the failure rate for chloroquine treatment was 44% (n = 300) and was comparable to the rate observed in continental Africa. Most treatment failures occurred afte...<br/><br/>V Andriantsoanirina, D Ménard, L Tuséo, A Ratsimbasoa, R Durand (2011) <i>Médecine tropicale : revue du Corps de santé colonial</i> <i></i> <i></i> 71: 3 298-304<br/>

http://publicationslist.org/remy.durand/refid76 2016-05-11T08:58:41Z

Recently, Plasmodium falciparum parasites bearing Pfdhfr I164L single mutation were found in Madagascar. These new mutants may challenge the use of antifolates for the intermittent preventive treatment of malaria during pregnancy (IPTp). Assays with transgenic bacteria suggested that I164L parasites have a wild-type phenotype for pyrimethamine but it had to be confirmed by testing the parasites th...<br/><br/>Valérie Andriantsoanirina, Rémy Durand, Bruno Pradines, Eric Baret, Christiane Bouchier, Arsène Ratsimbasoa, Didier Ménard (2011) <i>Malaria journal</i> <i></i> <i></i> 10: <br/>

http://publicationslist.org/remy.durand/refid3 2016-05-11T08:58:41Z

Resistance of head lice to pyrethroids induces difficult therapeutic problems. Previous studies demonstrated that this resistance was present in a French urban area, but its prevalence needed to be more precisely evaluated in terms of genotyping lice collected from more infested children over a certain period of time. We monitored the presence of the head lice kdr-like haplotype of the voltage-gat...<br/><br/>Rémy Durand, Sophie Bouvresse, Valérie Andriantsoanirina, Zohra Berdjane, Olivier Chosidow, Arezki Izri (2011) <i>Journal of medical entomology</i> <i></i> <i></i> 48: 1 73-75<br/>

http://publicationslist.org/remy.durand/refid5 2016-05-11T08:58:41Z

Large studies on severe imported malaria in non-endemic industrialized countries are lacking. We sought to describe the clinical spectrum of severe imported malaria in French adults and to identify risk factors for mortality at admission to the intensive care unit.<br/><br/>Fabrice Bruneel, Florence Tubach, Philippe Corne, Bruno Megarbane, Jean-Paul Mira, Eric Peytel, Christophe Camus, Frederique Schortgen, Elie Azoulay, Yves Cohen, Hugues Georges, Agnes Meybeck, Herve Hyvernat, Jean-Louis Trouillet, Eric Frenoy, Laurent Nicolet, Carine Roy, Remy Durand, Jacques Le Bras, Michel Wolff, (2010) <i>PloS one</i> <i></i> <i></i> 5: 10 <br/>

http://publicationslist.org/remy.durand/refid4 2016-05-11T08:58:41Z

Molecular studies have demonstrated that mutations in the Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) play a major role in chloroquine resistance, while mutations in P. falciparum multidrug resistance gene (Pfmdr-1) act as modulator. In Madagascar, the high rate of chloroquine treatment failure (44%) appears disconnected from the overall level of in vitro CQ susceptibilit...<br/><br/>Valérie Andriantsoanirina, Arsène Ratsimbasoa, Christiane Bouchier, Magali Tichit, Martial Jahevitra, Stéphane Rabearimanana, Rogelin Raherinjafy, Odile Mercereau-Puijalon, Rémy Durand, Didier Ménard (2010) <i>PloS one</i> <i></i> <i></i> 5: 10 <br/>

http://publicationslist.org/remy.durand/refid6 2016-05-11T08:58:41Z

We sought to test the association of polymorphisms in Plasmodium falciparum nhe-1 (Pfnhe-1, gene PF13_0019) with in vitro susceptibility to quinine, which was previously reported in a limited number of reference strains or culture-adapted isolates. Determination of in vitro susceptibility to quinine, genotyping of Pfnhe-1 ms4760 microsatellite and polymorphism in codon 76 of Pfcrt were performed f...<br/><br/>Valérie Andriantsoanirina, Didier Ménard, Stéphane Rabearimanana, Véronique Hubert, Christiane Bouchier, Magali Tichit, Jacques Le Bras, Rémy Durand (2010) <i>The American journal of tropical medicine and hygiene</i> <i></i> <i></i> 82: 5 782-787<br/>

http://publicationslist.org/remy.durand/refid7 2016-05-11T08:58:41Z

The combination of sulfadoxine-pyrimethamine is recommended for use as intermittent preventive treatment of malaria during pregnancy and is deployed in Africa. The emergence and the spread of resistant parasites are major threats to such an intervention. We have characterized the Plasmodium falciparum dhfr (pfdhfr) haplotypes and flanking microsatellites in 322 P. falciparum isolates collected fro...<br/><br/>Valérie Andriantsoanirina, Christiane Bouchier, Magali Tichit, Martial Jahevitra, Stéphane Rabearimanana, Rogelin Randrianjafy, Arsène Ratsimbasoa, Odile Mercereau-Puijalon, Rémy Durand, Didier Ménard (2010) <i>Antimicrobial agents and chemotherapy</i> <i></i> <i></i> 54: 6 2323-2329<br/>

http://publicationslist.org/remy.durand/refid8 2016-05-11T08:58:41Z

Malaria remains a major health problem in Madagascar. Over past decades, the burden of malarial disease has fluctuated over time, partly in line with the successes and failures of antimalarial policy. In the 1950s and 1960s, a sharp decline in malaria transmission was observed in the central highlands due to indoor spraying with DDT and to the massive use of chloroquine by the population. Followin...<br/><br/>Valérie Andriantsoanirina, Didier Ménard, Luciano Tuseo, Rémy Durand (2010) <i>Scandinavian journal of infectious diseases</i> <i></i> <i></i> 42: 1 22-32<br/>

http://publicationslist.org/remy.durand/refid9 2016-05-11T08:58:41Z

The aim of this study was to provide the first comprehensive spatiotemporal picture of Plasmodium falciparum resistance in various geographic areas in Madagascar. Additional data about the antimalarial resistance in the neighboring islands of the Comoros archipelago were also collected. We assessed the prevalence of pfcrt, pfmdr-1, pfdhfr, and pfdhps mutations and the pfmdr-1 gene copy number in 1...<br/><br/>Valérie Andriantsoanirina, Arsène Ratsimbasoa, Christiane Bouchier, Martial Jahevitra, Stéphane Rabearimanana, Rogelin Radrianjafy, Voahangy Andrianaranjaka, Tantely Randriantsoa, Marie Ange Rason, Magali Tichit, Léon Paul Rabarijaona, Odile Mercereau-Puijalon, Rémy Durand, Didier Ménard (2009) <i>Antimicrobial agents and chemotherapy</i> <i></i> <i></i> 53: 11 4588-4597<br/>

http://publicationslist.org/remy.durand/refid10 2016-05-11T08:58:41Z

We have developed a High-Resolution DNA Melting method to detect mutations related to Plasmodium falciparum resistance. This method is based on real-time PCR followed by High Resolution Melting ramping from 67 degrees C to 80 degrees C with fluorescence data acquisition set at 0.1 degrees C increments. The accuracy of the technique was assessed using 177 P. falciparum clinical isolates and two ref...<br/><br/>Valérie Andriantsoanirina, Vincent Lascombes, Arsène Ratsimbasoa, Christiane Bouchier, Jonathan Hoffman, Magali Tichit, Leon-Paul Rabarijaona, Rémy Durand, Didier Ménard (2009) <i>Journal of microbiological methods</i> <i></i> <i></i> 78: 2 165-170<br/>

http://publicationslist.org/remy.durand/refid13 2016-05-11T08:58:41Z

Post-malaria neurological syndrome (PMNS) defined by a post-infective encephalopathy occurring within 2 months after an episode of Plasmodium falciparum infection is still a debated entity. We describe 2 cases of PMNS in 2 patients of African origin, born and living in France. Both patients had severe P. falciparum infection, followed by PMNS. They recovered with no sequelae. These are the first-r...<br/><br/>Virginie Prendki, Claire Elzière, Rémy Durand, Aicha Hamdi, Yves Cohen, Igor Onnen, Olivier Bouchaud (2008) <i>The American journal of tropical medicine and hygiene</i> <i></i> <i></i> 78: 5 699-701<br/>

http://publicationslist.org/remy.durand/refid14 2016-05-11T08:58:41Z

In Gabon, following the adoption of amodiaquine/artesunate combination (AQ/AS) as first-line treatment of malaria and of sulphadoxine/pyrimethamine (SP) for preventive intermittent treatment of pregnant women, a clinical trial of SP versus AQ was conducted in a sub-urban area. This is the first study carried out in Gabon following the WHO guidelines.<br/><br/>Basile Nsimba, Vincent Guiyedi, Modeste Mabika-Mamfoumbi, Jean Romain Mourou-Mbina, Edgard Ngoungou, Marielle Bouyou-Akotet, Romaric Loembet, Rémy Durand, Jacques Le Bras, Maryvonne Kombila (2008) <i>Malaria journal</i> <i></i> <i></i> 7: <br/>

http://publicationslist.org/remy.durand/refid15 2011-07-20T07:45:49Z

We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum-infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability. The follow-up of such patients should be strengthened.<br/><br/>Rémy Durand, Virginie Prendki, Johann Cailhol, Véronique Hubert, Pascal Ralaimazava, Laurent Massias, Olivier Bouchaud, Jacques Le Bras (2008) <i>Emerg Infect Dis</i> <i></i> <i></i> 14: 2 320-322<br/>

http://publicationslist.org/remy.durand/refid11 2016-05-11T08:58:41Z

To investigate whether the severity of Plasmodium falciparum attack in endemic areas was associated with the multiplicity of infection (MOI) and/or with a particular genotype(s).<br/><br/>Rémy Durand, Frédéric Ariey, Sandrine Cojean, Arnaud Fontanet, Louise Ranaivo, Lanto-Alisoa Ranarivelo, Jeanne Aimée Vonimpaisomihanta, Didier Menard, Virginio Pietra, Jacques Le Bras, David Modiano, Milijaona Randrianarivelojosia (2008) <i>Tropical medicine & international health : TM & IH</i> <i></i> <i></i> 13: 11 1392-1399<br/>

http://publicationslist.org/remy.durand/refid12 2016-05-11T08:58:41Z

The adhesion of infected red blood cells (IRBCs) to the cell lining of microvasculature is thought to play a central role in the pathogenesis of severe malaria. Individual IRBC can bind to more than one host receptor and parasites with multiple binding phenotypes may cause severe disease more frequently. However, as most clinical isolates are multiclonal, previous studies were hampered by the diff...<br/><br/>S Cojean, S Jafari-Guemouri, J Le Bras, R Durand (2008) <i>Parasite (Paris, France)</i> <i></i> <i></i> 15: 2 163-169<br/>

http://publicationslist.org/remy.durand/refid18 2011-07-20T07:45:49Z

Plasmodium falciparum malaria is a serious health hazard for travelers to malaria-endemic areas and is often diagnosed on return to the country of residence. We conducted a retrospective study of imported falciparum malaria among travelers returning to France from malaria-endemic areas from 1996 through 2003. Epidemiologic, clinical, and parasitologic data were collected by a network of 120 labora...<br/><br/>Fabrice Legros, Olivier Bouchaud, Thierry Ancelle, Amandine Arnaud, Sandrine Cojean, Jacques Le Bras, Martin Danis, Arnaud Fontanet, Rémy Durand (2007) <i>Emerg Infect Dis</i> <i></i> <i></i> 13: 6 883-888<br/>

http://publicationslist.org/remy.durand/refid16 2011-07-20T07:45:49Z

Rémy Durand, Jacques Le Bras, Olivier Bouchaud (2007) <i>Rev Prat</i> <i></i> <i></i> 57: 14 1513-1515<br/>

http://publicationslist.org/remy.durand/refid20 2011-07-20T07:45:49Z

Inadequate treatment practices with antimalarials are considered major contributors to Plasmodium falciparum resistance to chloroquine, pyrimethamine and sulfadoxine. The longitudinal survey conducted in Dielmo, a rural Senegalese community, offers a unique frame to explore the impact of strictly controlled and quantified antimalarial use for diagnosed malaria on drug resistance.<br/><br/>Nitchakarn Noranate, Rémy Durand, Adama Tall, Laurence Marrama, André Spiegel, Cheikh Sokhna, Bruno Pradines, Sandrine Cojean, Micheline Guillotte, Emmanuel Bischoff, Marie-Thérèse Ekala, Christiane Bouchier, Thierry Fandeur, Frédéric Ariey, Jintana Patarapotikul, Jacques Le Bras, Jean François Trape, Christophe Rogier, Odile Mercereau-Puijalon (2007) <i>PLoS One</i> <i></i> <i></i> 2: 1 <br/>

http://publicationslist.org/remy.durand/refid17 2011-07-20T07:45:49Z

The head louse, Pediculus humanus capitis (De Geer), is an hematophagous ectoparasite that affects mainly children. Resistance to insecticides belonging to pyrethroids and other pediculicides, such as malathion, is responsible for frequently reported treatment failures. Recent studies showed that a M815I-T929I-L932F kdr-like mutation in the voltage-gated sodium channel alpha-subunit gene was assoc...<br/><br/>Rémy Durand, Bénédicte Millard, Claire Bouges-Michel, Christiane Bruel, Sophie Bouvresse, Arezki Izri (2007) <i>J Med Entomol</i> <i></i> <i></i> 44: 5 796-798<br/>

http://publicationslist.org/remy.durand/refid22 2011-07-20T07:45:49Z

Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas. CQR was reported in East Africa in the 1970's, and has since invaded the African continent. Many questions remain a...<br/><br/>Frédéric Ariey, Thierry Fandeur, Remy Durand, Milijaona Randrianarivelojosia, Ronan Jambou, Eric Legrand, Marie Thérèse Ekala, Christiane Bouchier, Sandrine Cojean, Jean Bernard Duchemin, Vincent Robert, Jacques Le Bras, Odile Mercereau-Puijalon (2006) <i>Malar J</i> <i></i> <i></i> 5: <br/>

http://publicationslist.org/remy.durand/refid23 2011-07-20T07:45:49Z

Plasmodium falciparum drug resistance represents a major health problem in malaria endemic countries. The mechanisms of resistance are not fully elucidated. Recently, an association between putative transporter gene polymorphisms and in vitro response to chloroquine (CQ) and quinine has been reported in culture-adapted, cloned isolates from various geographical origins. However, this was not confi...<br/><br/>Sandrine Cojean, Alain Noël, Dimitri Garnier, Véronique Hubert, Jacques Le Bras, Rémy Durand (2006) <i>Malar J</i> <i></i> <i></i> 5: <br/>

http://publicationslist.org/remy.durand/refid80 2016-05-11T10:15:30Z

In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.<br/><br/>Francesco Grandesso, Andres Hagerman, Sarian Kamara, Eva Lam, Francesco Checchi, Suna Balkan, Giuseppe Scollo, Rémy Durand, Jean-Paul Guthmann (2006) <i>Tropical medicine & international health : TM & IH</i> <i></i> <i></i> 11: 7 1017-1021<br/>

http://publicationslist.org/remy.durand/refid24 2011-07-20T07:45:49Z

We examined the atovaquone in vitro susceptibility and the cytochrome b (cytb) gene polymorphism of African Plasmodium falciparum isolates during the first years of atovaquone/proguanil use.<br/><br/>Lise Musset, Bruno Pradines, Daniel Parzy, Rémy Durand, Patricia Bigot, Jacques Le Bras (2006) <i>J Antimicrob Chemother</i> <i></i> <i></i> 57: 1 110-115<br/>

http://publicationslist.org/remy.durand/refid21 2011-07-20T07:45:49Z

Procalcitonin (PCT) has been found elevated in complicated forms of Plasmodium falciparum malaria. Its usefulness has almost never been assessed in uncomplicated falciparum malaria.<br/><br/>Bernard Uzzan, Arezki Izri, Rémy Durand, Michèle Deniau, Olivier Bouchaud, Gérard-Yves Perret (2006) <i>Travel Med Infect Dis</i> <i></i> <i></i> 4: 2 77-80<br/>

http://publicationslist.org/remy.durand/refid19 2011-07-20T07:45:49Z

Sandrine Cojean, Véronique Hubert, Jacques Le Bras, Rémy Durand (2006) <i>Emerg Infect Dis</i> <i></i> <i></i> 12: 11 1798-1799<br/>

http://publicationslist.org/remy.durand/refid27 2011-07-20T07:45:49Z

Controversy exists about which antimalarial chemoprophylaxis regimen should be used among travellers to Africa: the WHO and other experts recommend the use of mefloquine throughout sub-Saharan Africa, whereas French experts still support the combination of chloroquine and proguanil in most of West Africa (the so-called zone 2 countries). In this case-control study based at a travel clinic, we exam...<br/><br/>Arnaud L Fontanet, Sandrine Houzé, Annick Keundjian, Ricarda Schiemann, Pascal Ralaimazava, Rémy Durand, Olivier Cha, Jean-Pierre Coulaud, Jacques Le Bras, Olivier Bouchaud (2005) <i>Trans R Soc Trop Med Hyg</i> <i></i> <i></i> 99: 2 91-100<br/>

http://publicationslist.org/remy.durand/refid81 2016-05-11T10:17:44Z

In Congo, urgent efforts are needed to help with the revision of the national antimalarial drug policy. Despite its high resistance level, chloroquine (CQ) is still extensively used as the first-line treatment for uncomplicated Plasmodium falciparum malaria. The study was conducted in children under 5 years with uncomplicated malaria in Pointe-Noire and Brazzaville, the two largest cities that con...<br/><br/>Basile Nsimba, Sayeh Jafari-Guemouri, David A Malonga, André M Mouata, Jeannine Kiori, Frédéric Louya, Dominique Yocka, Maurice Malanda, Rémy Durand, Jacques Le Bras (2005) <i>Tropical medicine & international health : TM & IH</i> <i></i> <i></i> 10: 10 1030-1037<br/>

http://publicationslist.org/remy.durand/refid25 2011-07-20T07:45:49Z

Among populations living in areas endemic for malaria, repeated parasite exposure leads to a gradual increase in protective immunity to the disease. In contrast, this immunity is assumed to disappear after several years of non-exposure. This study was designed to investigate long-term immunity in subjects removed from the risk of exposure. Plasmodium falciparum malaria attacks occurring after shor...<br/><br/>Olivier Bouchaud, Michel Cot, Sabine Kony, Rémy Durand, Ricarda Schiemann, Pascal Ralaimazava, Jean-Pierre Coulaud, Jacques Le Bras, Philippe Deloron (2005) <i>Am J Trop Med Hyg</i> <i></i> <i></i> 72: 1 21-25<br/>

http://publicationslist.org/remy.durand/refid82 2016-05-11T10:18:39Z

To provide nationally relevant information on the antimalarial efficacy of chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ) in Sierra Leone, with a view to updating antimalarial policy in the country.<br/><br/>Francesco Checchi, Paul Roddy, Sarian Kamara, Arthur Williams, Guy Morineau, Abdul Rahman Wurie, Bona Hora, Nadine de Lamotte, Tim Baerwaldt, Annette Heinzelmann, Alison Danks, Loretxu Pinoges, Aggrey Oloo, Rémy Durand, Lisa Ranford-Cartwright, Martin Smet, (2005) <i>Tropical medicine & international health : TM & IH</i> <i></i> <i></i> 10: 2 146-153<br/>

http://publicationslist.org/remy.durand/refid83 2016-05-11T10:19:26Z

A 12-year-old Dutch boy was admitted because of severe neurotrauma after a traffic accident. On day 33 after admission, a Plasmodium falciparum infection was found in a routine blood smear. Most probably he was infected by blood of a patient next to him, a girl with severe malaria tropica. The genotype of the P. falciparum in both patients was identical.<br/><br/>Dirk H Winterberg, Peter C Wever, Cora van Rheenen-Verberg, Oscarina Kempers, Rémy Durand, Albert P Bos, Arianne H Teeuw, Lodewijk Spanjaard, Jacob Dankert (2005) <i>The Pediatric infectious disease journal</i> <i></i> <i></i> 24: 1 89-91<br/>

http://publicationslist.org/remy.durand/refid28 2011-07-20T07:45:49Z

We have developed a new fragment-analysis method to enumerate the clones and to quantify their proportions within Plasmodium falciparum isolates. We prospectively enrolled 20 adult patients with uncomplicated malaria who were returning to France from various sub-Saharan countries, from January 2000 through July 2001. The analysis of clonal populations was performed on blood samples obtained at 10 ...<br/><br/>Sayeh Jafari, Jacques Le Bras, Olivier Bouchaud, Rémy Durand (2004) <i>J Infect Dis</i> <i></i> <i></i> 189: 2 195-203<br/>

http://publicationslist.org/remy.durand/refid26 2011-07-20T07:45:49Z

Msp-1 and Msp-2 genes, each present as a unique copy in the genome of Plasmodium, contain polymorphic repeats in bloc 2. We studied allelic polymorphism of Msp-1 and Msp-2 by amplifying bloc 2 with a fluorescent primer, and analysing the fragment generated. We validated this method by mixing two cloned strains: chloroquine-susceptible HB3-Honduras and chloroquine-resistant FCM29-Cameroon. This met...<br/><br/>Halima Kaddouri, Sayeh Jafari, Rémy Durand, Jacques Le Bras (2004) <i>J Soc Biol</i> <i></i> <i></i> 198: 3 199-206<br/>

http://publicationslist.org/remy.durand/refid29 2011-07-20T07:45:49Z

The number of travellers in malaria striken areas increases each year (2). The risk of infection is high in Sub-Saharan Africa, but appropriate chemoprophylaxis can reduce the morbidity and mortality rate of malaria. Half of the samples of malaria cases received by the National reference centre of malaria chemosensibility (CNRCP) for chemosensibility analysis came from two hospitals in the north o...<br/><br/>P Ralaimazava, O Bouchaud, N Godineau, S Hamane, A Keundjian, R Durand, J Le Bras (2003) <i>Bull Soc Pathol Exot</i> <i></i> <i></i> 96: 2 119-122<br/>

http://publicationslist.org/remy.durand/refid30 2011-07-20T07:45:49Z

To assess the relationship between the presence of DHFR and DHPS mutations in Plasmodium falciparum, parasite in vitro resistance, and in vivo efficacy of sulfadoxine-pyrimethamine (SP) treatment.<br/><br/>Agnès Aubouy, Sayeh Jafari, Virginie Huart, Florence Migot-Nabias, Justice Mayombo, Rémy Durand, Mohamed Bakary, Jacques Le Bras, Philippe Deloron (2003) <i>J Antimicrob Chemother</i> <i></i> <i></i> 52: 1 43-49<br/>

http://publicationslist.org/remy.durand/refid32 2011-07-20T07:45:49Z

Drug-resistant malaria is primarily caused by Plasmodium falciparum, a species highly prevalent in tropical Africa, the Amazon region and South-east Asia. It causes severe fever or anaemia that leads to more than a million deaths each year. The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality among inhabitants of some endemic regions. The ration...<br/><br/>Jacques Le Bras, Rémy Durand (2003) <i>Fundam Clin Pharmacol</i> <i></i> <i></i> 17: 2 147-153<br/>

http://publicationslist.org/remy.durand/refid35 2011-07-20T07:45:49Z

Little is known about severe imported malaria in nonendemic industrialized countries. The purpose of this retrospective study was to describe the clinical spectrum of severe imported malaria in adults and to determine factors that were present at admission and were associated with in-intensive care unit mortality. This retrospective study evaluated the 188 patients who were admitted to our intensi...<br/><br/>Fabrice Bruneel, Laurent Hocqueloux, Corinne Alberti, Michel Wolff, Sylvie Chevret, Jean-Pierre Bédos, Rémy Durand, Jacques Le Bras, Bernard Régnier, François Vachon (2003) <i>Am J Respir Crit Care Med</i> <i></i> <i></i> 167: 5 684-689<br/>

http://publicationslist.org/remy.durand/refid31 2011-07-20T07:45:49Z

In south-eastern Iran, the sulfadoxine-pyrimethamine (SP) combination has been used to treat malaria caused by chloroquine-resistant Plasmodium falciparum. To explore the molecular basis of antimalarial resistance in this region, the dhfr, dhps and pfcrt genes of 50 clinical isolates of P. falciparum, collected from cases of uncomplicated malaria in 2000-2001, were checked for the point mutations ...<br/><br/>S Jafari, J Le Bras, M Asmar, R Durand (2003) <i>Ann Trop Med Parasitol</i> <i></i> <i></i> 97: 2 119-124<br/>

http://publicationslist.org/remy.durand/refid37 2011-07-20T07:45:49Z

Four airport malaria cases have been observed in the vicinity of the Roissy-Charles-de-Gaulle International Airport, Paris, France. These cases were geographically very close to each other and clustered in a short period of time during the summer of 1999. The phenotype and genotype of the Plasmodium falciparum isolates obtained from these patients were determined in order to know whether a single ...<br/><br/>S Jafari, R Durand, D Lusina, J Le Bras (2002) <i>Parasite</i> <i></i> <i></i> 9: 2 187-191<br/>

http://publicationslist.org/remy.durand/refid33 2011-07-20T07:45:49Z

In 2000, the chemosusceptibility of imported malaria was stable in France. All countries of infection considered, the bi-resistance to chloroquine and cycloguanil has not changed from 1996 to 2000. The monotherapy using quinine or mefloquine remains the first-line treatment to falciparum malaria. Resistance to these two antimalarials is rare in Africa and has not evolved over the past 15 years.<br/><br/>P Ralaimazava, R Durand, N Godineau, A Keundjian, Z Jezic, B Pradines, O Bouchaud, J Le Bras (2002) <i>Euro Surveill</i> <i></i> <i></i> 7: 7 113-118<br/>

http://publicationslist.org/remy.durand/refid36 2011-07-20T07:45:49Z

A PCR-based technique using molecular beacons was developed to detect the chloroquine resistance-associated pfcrt K76T point mutation in Plasmodium falciparum. One hundred thirty African clinical isolates were tested by the new method in comparison with the PCR-restriction fragment length polymorphism method. This rapid and inexpensive genomic assay could expand the possibilities for monitoring ch...<br/><br/>Rémy Durand, Virginie Huart, Sayeh Jafari, Jacques Le Bras (2002) <i>Antimicrob Agents Chemother</i> <i></i> <i></i> 46: 8 2684-2686<br/>

http://publicationslist.org/remy.durand/refid34 2011-07-20T07:45:49Z

In Liberia, little information is available on the efficacy of antimalarials against Plasmodium falciparum malaria. We measured parasitological resistance to chloroquine and sulfadoxine-pyrimethamine (SP) in Harper, south-west Liberia in a 28-d study in vivo. A total of 50 patients completed follow-up in the chloroquine group, and 66 in the SP group. The chloroquine failure rate was 74.0% (95% con...<br/><br/>F Checchi, R Durand, S Balkan, B T Vonhm, J Z Kollie, P Biberson, E Baron, J Le Bras, J P Guthmann (2002) <i>Trans R Soc Trop Med Hyg</i> <i></i> <i></i> 96: 6 664-669<br/>

http://publicationslist.org/remy.durand/refid42 2011-07-20T07:50:38Z

Drug resistant malaria is mostly due to Plasmodium falciparum, a species highly prevalent in tropical Africa, Amazon and Southeast Asia. P. falciparum is responsible for severe involvement of fever or anaemia prompting more than a million deaths per year. The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality in some human populations from endemic...<br/><br/>J Le Bras, R Durand (2001) <i>Ann Pharm Fr</i> <i></i> <i></i> 59: 2 85-92<br/>

http://publicationslist.org/remy.durand/refid43 2011-07-20T07:50:38Z

C Giverne, F Bruneel, B Gachot, R Durand, J Le Bras (2001) <i>Presse Med</i> <i></i> <i></i> 30: 10 488-489<br/>

http://publicationslist.org/remy.durand/refid41 2011-07-20T07:50:38Z

Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine resistance in Plasmodium falciparum, was not the resistance determinant. A further analysis of the initial 36 kb locus comprising the cg2 gene led to the discovery of another gene, pfcrt, which was absolutely associated with chloroquine resistance in forty parasite lines [Fidock DA, Nomura T, Talley AT, Su XZ...<br/><br/>R Durand, S Jafari, J Vauzelle, J F Delabre, Z Jesic, J Le Bras (2001) <i>Mol Biochem Parasitol</i> <i></i> <i></i> 114: 1 95-102<br/>

http://publicationslist.org/remy.durand/refid39 2011-07-20T07:50:38Z

R Durand, S Jafari, O Bouchaud, P Ralaimazava, A Keundjian, J Le Bras (2001) <i>J Infect Dis</i> <i></i> <i></i> 184: 12 1633-1634<br/>

http://publicationslist.org/remy.durand/refid38 2011-07-20T07:50:38Z

Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine resistance in Plasmodium faiciparum, was not the resistance determinant. A further analysis of the initial 36 kb locus comprising the cg2 gene led to the discovery of another gene, pfcrt, which was absolutely associated with chloroquine resistance in forty parasite lines. The aim of this study was to evaluate...<br/><br/>R Durand, J Le Bras (2001) <i>Ann Pharm Fr</i> <i></i> <i></i> 59: 5 312-318<br/>

http://publicationslist.org/remy.durand/refid40 2011-07-20T07:50:38Z

The parasitic loads of mouse livers experimentally infected with Leishmania infantum were determined using a double real-time quantitative PCR test targeted to the parasite DNA polymerase gene and to the mouse brain-derived neutrophic factor gene. The Leishmania DNA copy number was normalized to the number of mouse gene copies in order to quantify the former independently of liver weight. The corr...<br/><br/>S Bretagne, R Durand, M Olivi, J F Garin, A Sulahian, D Rivollet, M Vidaud, M Deniau (2001) <i>Clin Diagn Lab Immunol</i> <i></i> <i></i> 8: 4 828-831<br/>

http://publicationslist.org/remy.durand/refid45 2011-07-20T07:50:38Z

The purpose of this prospective study was to update epidemiological data on cutaneous larva migrans (CLM) and to assess the therapeutic efficacy of ivermectin. We performed the study between June 1994 and December 1998 at our travel clinic. Ivermectin (a single dose of 200 microg/kg) was offered to all the patients with CLM, and its efficacy and tolerability were assessed by a questionnaire. Sixty...<br/><br/>O Bouchaud, S Houzé, R Schiemann, R Durand, P Ralaimazava, C Ruggeri, J P Coulaud (2000) <i>Clin Infect Dis</i> <i></i> <i></i> 31: 2 493-498<br/>

http://publicationslist.org/remy.durand/refid44 2011-07-20T07:50:38Z

A PCR-based technique using new fluorescent probes, called molecular beacons, was developed to detect the antifolate resistance-associated S108N point mutation in Plasmodium falciparum. One hundred African clinical isolates were tested by the new method in comparison with the PCR-restriction fragment length polymorphism method. This new molecular technique appears to be a promising tool for epidem...<br/><br/>R Durand, J Eslahpazire, S Jafari, J F Delabre, A Marmorat-Khuong, J P di Piazza, J Le Bras (2000) <i>Antimicrob Agents Chemother</i> <i></i> <i></i> 44: 12 3461-3464<br/>

http://publicationslist.org/remy.durand/refid47 2011-07-20T07:50:38Z

The correlation between the structure of two short sequences from the Plasmodium falciparum cg2 gene and parasite chloroquine susceptibility was evaluated in unselected clinical isolates obtained from travellers returning mainly from Africa to France in 1995 and 1996. As determined by an isotopic semi-microtest, 74 isolates were susceptible to chloroquine (50% inhibitory concentration < 80 nM), 13...<br/><br/>R Durand, E Gabbett, J P Di Piazza, J F Delabre, J Le Bras (1999) <i>Mol Biochem Parasitol</i> <i></i> <i></i> 101: 1-2 185-197<br/>

http://publicationslist.org/remy.durand/refid46 2011-07-20T07:50:38Z

The incidence of cycloguanil resistance in 501 Plasmodium falciparum isolates from individuals entering France from Africa was estimated by a method based on PCR-restriction-fragment-length polymorphisms. None of the subjects had taken antifol prophylaxis. Annual incidence of the resistance, detected as a point mutation at codon 108 in the parasite's dihydrofolate-reductase gene, increased from 19...<br/><br/>R Durand, J P di Piazza, C Longuet, Y Sécardin, J Clain, J le Bras (1999) <i>Ann Trop Med Parasitol</i> <i></i> <i></i> 93: 1 25-30<br/>

http://publicationslist.org/remy.durand/refid50 2011-07-20T07:50:38Z

Amphotericin B (AmB) has been used as a second-line treatment of visceral leishmaniasis, particularly in human immunodeficiency virus-positive patients. AmB median effective doses (ED50s) were determined on an isolate obtained before any treatment and on a second isolate obtained 4 years later from the same AmB-treated patient. ED50s were similar (0.059 and 0.067 mg/kg of body weight, respectively...<br/><br/>R Durand, M Paul, F Pratlong, D Rivollet, M L Dubreuil-Lemaire, R Houin, A Astier, M Deniau (1998) <i>Antimicrob Agents Chemother</i> <i></i> <i></i> 42: 8 2141-2143<br/>

http://publicationslist.org/remy.durand/refid49 2011-07-20T07:50:38Z

Assess the efficacy of preventive and curative treatments of imported malaria.<br/><br/>J Le Bras, R Durand, J P di Piazza, B Pradines, C Longuet, D Parzy (1998) <i>Presse Med</i> <i></i> <i></i> 27: 28 1419-1423<br/>

http://publicationslist.org/remy.durand/refid48 2011-07-20T07:50:38Z

The in vitro susceptibility of chloroquine and the genomic profile of dihydrofolate reductase (DHFR) codon 108 was determined against african isolates of P. falciparum (Pf) from imported malaria cases without previous drug intake by an isotopic microtest or PCR + RFLP. Pf resistance to chloroquine or to the DHFR inhibitor was present in 49% and 46% of isolates, respectively. Pf drug resistance was...<br/><br/>J Le Bras, B Pradines, J P di Piazza, R Durand, N Godineau, O Bouchaud, R Roué, B Marchou, G Martet, C Longuet, D Parzy (1998) <i>Bull Soc Pathol Exot</i> <i></i> <i></i> 91: 5 Pt 1-2 490-492<br/>

http://publicationslist.org/remy.durand/refid84 2016-05-11T10:25:25Z

This work describes the preparation, the physicochemical properties, the tolerance and the intracellular trafficking of pentamidine loaded nanoparticles. Pentamidine was bound to the polymer by ionic interaction. This interaction involved the carboxylic acid functions of methacrylic acid (10% of the polymer) and the amine groups of the drug. Pentamidine fixation and release were pH dependent. An a...<br/><br/>M Paul, R Durand, Y Boulard, T Fusaï, C Fernandez, D Rivollet, M Deniau, A Astier (1998) <i>Journal of drug targeting</i> <i></i> <i></i> 5: 6 481-490<br/>

http://publicationslist.org/remy.durand/refid85 2016-05-11T10:28:00Z

The activity of pentamidine-loaded poly(D,L-lactide) nanoparticles was compared, by determination of median effective doses (ED50), to that of free pentamidine in a murine model of visceral leishmaniasis induced by Leishmania infantum. BALB/c mice were infected intravenously on day O with promastigotes and then treated on days 14, 16, and 18. Groups of 5 mice received either 0.57, 1.14 and 2.28 mg...<br/><br/>R Durand, M Paul, D Rivollet, H Fessi, R Houin, A Astier, M Deniau (1997) <i>Parasite (Paris, France)</i> <i></i> <i></i> 4: 4 331-336<br/>

http://publicationslist.org/remy.durand/refid86 2016-05-11T10:28:41Z

The efficacy of a new liposomal formulation of amphotericin B was compared to that of amphotericin B deoxycholate (Fungizone) in a murine model of visceral leishmaniasis induced by Leishmania infantum. Median effective doses (ED50) were determined with two different strains: strain 1 was obtained from an untreated patient, and strain 2 was obtained from a patient who had received 12.5 g of amphote...<br/><br/>M Paul, R Durand, H Fessi, D Rivollet, R Houin, A Astier, M Deniau (1997) <i>Antimicrobial agents and chemotherapy</i> <i></i> <i></i> 41: 8 1731-1734<br/>

http://publicationslist.org/remy.durand/refid52 2011-07-20T07:50:38Z

R Durand, O Ramiliarisoa, Y Sécardin, P Eldin de Pécoulas, L K Basco, J Le Bras (1997) <i>Trans R Soc Trop Med Hyg</i> <i></i> <i></i> 91: 4 460-461<br/>

http://publicationslist.org/remy.durand/refid51 2011-07-20T07:50:38Z

The use of drug delivery systems may reduce the toxicity and improve the activity of antileishmanial compounds. In view of such a strategy, we loaded the antileishmanial agent pentamidine on polymethacrylate nanoparticles. The activity of pentamidine-loaded nanoparticles was compared with that of free pentamidine in a BALB/c mice model of visceral leishmaniasis induced by Leishmania infantum. On d...<br/><br/>R Durand, M Paul, D Rivollet, R Houin, A Astier, M Deniau (1997) <i>Int J Parasitol</i> <i></i> <i></i> 27: 11 1361-1367<br/>

http://publicationslist.org/remy.durand/refid53 2011-07-20T07:50:38Z

Drug targeting enhances drug efficacy. This principle was tested in the treatment of an experimental visceral leishmaniasis. Using transmission electron microscopy (TEM) we localized pentamidine-loaded polymethocrylate nanoparticles in the liver of mice infected with Leishmania major and compared the ultrastructural changes in the parasites of these mice when they were treated with bound versus fr...<br/><br/>T Fusai, Y Boulard, R Durand, M Paul, C Bories, D Rivollet, A Astier, R Houin, M Deniau (1997) <i>Parasite</i> <i></i> <i></i> 4: 2 133-139<br/>

http://publicationslist.org/remy.durand/refid54 2011-07-20T07:50:38Z

A PCR enzyme-linked immunosorbent assay (ELISA) involving the use of bone marrow aspirates (BMA) and blood samples (BS) for the diagnosis of visceral leishmaniasis (VL) in human immunodeficiency virus-infected patients was developed with primers selected from the sequence of the small-subunit rRNA gene and compared with direct examination and in vitro cultivation. The PCR was optimized for routine...<br/><br/>J M Costa, R Durand, M Deniau, D Rivollet, M Izri, R Houin, M Vidaud, S Bretagne (1996) <i>J Clin Microbiol</i> <i></i> <i></i> 34: 7 1831-1833<br/>

http://publicationslist.org/remy.durand/refid55 2011-07-20T07:50:38Z

Visceral leishmaniasis is caused by hemoflagellate protozoa which are obligatory parasites of the mononuclear phagocyte system. Leishmaniasis causes high morbidity and mortality worldwide. The treatment of choice remains pentavalent antimonials, but high toxicity and failures have been reported. An alternative to conventional treatment is delivery anti-leishmania agents using colloidal carrier sys...<br/><br/>T Fusai, R Durand, Y Boulard, M Paul, C Bories, D Rivollet, R Houin, M Deniau (1995) <i>Med Trop (Mars)</i> <i></i> <i></i> 55: 1 73-78<br/>

http://publicationslist.org/remy.durand/refid56 2011-07-20T07:50:38Z

The efficiency of antileishmanial agents may be enhanced by improving their bioavailability with a colloidal drug carrier. We have investigated the action of free pentamidine, compared with pentamidine bound to polymethacrylate nanoparticles, in a rodent model. BALB/c mice were infected, via the tail vein, with 4 x 10(7) L. major (MON 74) promastigotes. Twelve days after infection, seven groups of...<br/><br/>T Fusai, M Deniau, R Durand, C Bories, M Paul, D Rivollet, A Astier, R Houin (1994) <i>Parasite</i> <i></i> <i></i> 1: 4 319-324<br/>

http://publicationslist.org/remy.durand/refid57 2016-05-11T09:19:16Z

Antileishmanial chemotherapy is hampered by the location of parasites within lysosomal vacuoles of the macrophages which restricts the bioavailability of many potential antileishmanial compounds. In this study, the effectiveness of pentamidine targeted to the infected cells by a linkage to a colloidal drug carrier, methacrylate polymer nanoparticles was explored. In the same way, polyisoalkylcyano...<br/><br/>M Deniau, R Durand, C Bories, M Paul, A Astier, P Couvreur, R Houin (1993) <i>Annales de parasitologie humaine et comparée</i> <i></i> <i></i> 68: 1 34-37<br/>