Roland Meesters's Publications List

Dried Blood Spots UHPLC-MS/MS Analysis of Oseltamivir and Oseltamivircarboxylate – a validated assay for the clinic

2011-07-14T06:05:27Z

Gero P Hooff, Roland JW Meesters, Jeroen JA van Kampen, Nick A van Huizen, Birgit Koch, Asmar FY Al Hadithy, Teun van Gelder, Albert DME Osterhaus, Rob A Gruters, Theo M Luider (2011) Anal.Biochem.Chem. 400: 10 3473-3479

Ultra-fast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution tandem mass spectrometry

2011-06-19T07:15:51Z

R.J.W. Meesters, E. den Boer, R.A. Mathot, R. de Jonge, R. van Klaveren, J.lindemans and T.Luider (2011) Bioanalysis 3: 12 1369-1378

Determination of the antiretroviral drug tenofovir in plasma from HIV infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry

2011-03-10T19:02:33Z

Roland J.W. Meesters, Jeroen J.A. van Kampen, Rachel D. Scheuer, Marchina E. van der Ende , Rob A. Gruters and Theo M. Luider (2011) J. Mass. Spectrom 46: 282-289

Impact of internal standard addition on dried blood spot analysis in bioanalytical method development

2011-10-22T06:05:24Z

Roland J.W. Meesters, Gero Hooff, Nick van Huizen, Rob Gruters and Theo Luider (2011) Bioanalysis 3: 20 2357-2364

A novel strategy for the identification of β-lactamase activity in bacterial lysates using ultra fast mass spectrometry (MALDI-MS)

2011-07-14T06:06:30Z

Gero P. Hooff, Jeroen J.A. van Kampen, Roland J.W. Meesters, Alex van Belkum, Wil H.F. Goessens, Theo M. Luider (2011) Journal of Clinical Microbiology, under review :

Analytical Investigations of Toxic p-Phenylenediamine (PPD) Levels in Clinical Urine Samples with Special Focus on MALDI-MS/MS

2011-08-05T17:49:07Z

Gero Peter Hooff; Nick A van Huizen; Roland JW Meesters; Ed E Zijlstra; Mohamed Abdelraheem; Waleed Abdelraheem; Mohamed Hamdouk; Jan Lindemans; Theo M Luider (2011) PloS ONE 6: 8 e22191

Assesment of intracellular methotrexate and methotrexateployglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry

2011-10-22T06:03:31Z

Roland J.W. Meesters, Ethan den Boer, Robert de Jonge, Jan Lindemans and Theo M. Luider (2011) Rapid Commun. Mass Spectrom 25: 3063-3070

Application of MALDI-triple quadrupole mass spectrometry for the quantification of small molecules in biomedical research

2011-08-09T07:57:35Z

Roland. J.W. Meesters (2011)

Impact of internal standard addition on dried blood spot analysis in method development

2011-07-14T06:06:10Z

Roland J.W. Meesters, Gero P. Hoof, Nick van Huizen, Rob A. Gruters and Theo M. Luider (2011) accepted for publication in Bioanalysis :

Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast MALDI-triple quadrupole tandem mass spectrometry

2011-06-19T07:16:50Z

Roland J.W. Meesters, Ethan den Boer, Robert de Jonge, Jan Lindemans and Theo M. Luider (2011) In revision, Rapid communication in mass spectrometry :

Roland J.W. Meesters, Jeroen J.A. van Kampen, Mariska L. Reedijk, Rachel D. Scheuer, Lennard J.M. Dekker, David M. Burger, Nico G. Hartwig, Albert D.M.E. Osterhaus, Theo M. Luider and Rob A.Gruters

2010-07-09T19:02:24Z

Ultrafast and high-throughput therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots (2010) FIP Pharmaceutical Sciences 2010 World Congress, New Orleans-USA, November 14-17, 2010

A new ultrafast and high-throughput assay for disease-specific diagnostics of collagen and collagen cross-links

2010-07-09T19:13:17Z

Roland J.W. Meesters , Yvonne M. Bastiaansen-Jenniskens, Joris Harlaar, Johan F. Lange, Gerjo J.V.M. van Osch and Theo M.Luider (2010) Biomedica 2010, Aachen-Germany, March 17-19, 2010

Ultrafast and high-throughput therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots

2010-07-09T19:03:50Z

Roland J.W. Meesters, Jeroen J.A. van Kampen, Mariska L. Reedijk, Rachel D. Scheuer, Lennard J.M. Dekker, David M. Burger, Nico G. Hartwig, Albert D.M.E. Osterhaus, Theo M. Luider and Rob A.Gruters (2010) 1.st AB SCIEX European Conference on MS/MS (ECMSMS), Noorwijkerhout-the Netherlands, October 6-7, 2010

Ultrafast and high-throughput therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots

2010-07-09T19:02:11Z

Roland J.W. Meesters, Jeroen J.A. van Kampen, Mariska L. Reedijk, Rachel D. Scheuer, Lennard J.M. Dekker, David M. Burger, Nico G. Hartwig, Albert D.M.E. Osterhaus, Theo M. Luider and Rob A.Gruters (2010) TIPharma springmeeting 2010, Utrecht-the Netherlands, April 15, 2010

Ultrafast and high-throughput therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots

2010-07-09T19:22:34Z

R.A. Gruters, R.J.W. Meesters, J.J.A. van Kampen, D. M. Burger, N. G. Hartwig, T. M. Luider et al. (2010) Antiviral Congress, Amsterdam-the Netherlands, November 7-9, 2010

A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate Pemetrexed in plasma from lung cancer patients

2010-11-23T08:34:42Z

Roland J.W.Meesters, Robin Cornelissen, Rob J. van Klaveren, Robert de Jonge, Ethan den Boer, Jan Lindemans and Theo M. Luider (2010) Anal. Bioanal. Chem. 398: 7-8 2943-2948

Ultrafast and high-throughput therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots

2010-07-09T18:58:04Z

Roland J.W. Meesters, Jeroen J.A. van Kampen, Mariska L. Reedijk, Rachel D. Scheuer, Lennard J.M. Dekker, David M. Burger, Nico G. Hartwig, Albert D.M.E. Osterhaus, Theo M. Luider and Rob A.Gruters (2010) FIGON Dutch Medicine Days, Lunteren-the Netherlands, October 4-6, 2010

MALDI-MS/MS analyses of antiretroviral drugs used in HIV-1 treatment

2010-07-09T19:09:52Z

Roland J.W. Meesters, Jeroen J.A. van Kampen, Mariska L. Reedijk, Rachel D. Scheuer, Lennard J.M. Dekker, David M. Burger, Nico G. Hartwig, Albert D.M.E. Osterhaus, Theo M. Luider and Rob A.Gruters (2010) HTC-11 congress, Bruges-Belgium, January 27-29, 2010

Pediatric therapeutic drug monitoring of the protease inhibitor Lopinavir and two metabolites in HIV-1 infected children treated with Kaletra®

2010-07-09T19:25:51Z

RJW Meesters, JJA van Kampen, ML Reedijk, RD Scheuer, LJM Dekker, DM. Burger, R de Groot, NG Hartwig, ADME Osterhaus, RA Gruters and TM Luider (2010) FIGON 2010 Dutch Medicine Days, Lunteren-the Netherlands, October 4-6, 2010

Resistance to HIV protease inhibitor lopinavir in a human T cell line (CEM) is associated with ABCG1 downregulation and decreased apoptosis capacity

2010-09-30T13:46:53Z

Wouter F.W. Bierman, George L. Scheffer, Monique Nijhuis, Dorien de Jong, Roland J.W. Meesters, Jeroen J.A. van Kampen, Ruud Oerlemans, Jean-Pierre Gillet, Saskia A.G.M. Cillessen, Gerrit Jansen, Sven A. Danner, Michiel A. van Agtmael, Rik J. Scheper. (2010) submitted :

Ultrafast and high-throughput therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots

2010-10-31T07:14:44Z

Roland J W Meesters, Jeroen J A van Kampen, Mariska L Reedijk, Rachel D Scheuer, Lennard J M Dekker, David M Burger, Nico G Hartwig, Albert D M E Osterhaus, Theo M Luider, Rob A Gruters (2010) NVMS Fall meeting, October 28, Amsterdam, the Netherlands

Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots.

2010-09-02T19:02:23Z

Kaletra (Abott Laboratories) is a co-formulated medication used in the treatment of HIV-1-infected children, and it contains the two antiretroviral protease inhibitor drugs lopinavir and ritonavir. We validated two new ultrafast and high-throughput mass spectrometric assays to be used for therapeutic drug monitoring of lopinavir and ritonavir concentrations in whole blood and in plasma from HIV-1-...

Roland J W Meesters, Jeroen J A van Kampen, Mariska L Reedijk, Rachel D Scheuer, Lennard J M Dekker, David M Burger, Nico G Hartwig, Albert D M E Osterhaus, Theo M Luider, Rob A Gruters (2010) Anal Bioanal Chem 398: 1 319-328

Application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of stable isotope enrichments of phenylalanine and tyrosine.

2010-09-02T19:02:23Z

Whole-body protein synthesis and breakdown are measured by a combined tracer infusion protocol with the stable isotope amino acids L-[ring-(2)H(5)]-phenylalanine, L-[ring-(2)H(2)]-tyrosine and L-[ring-(2)H(4)]-tyrosine that enable the measurement of the phenylalanine to tyrosine conversion rate. We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the measurement of v...

Roland J W Meesters, Robert R Wolfe, Nicolaas E P Deutz (2009) J Chromatogr B Analyt Technol Biomed Life Sci 877: 1-2 43-49

Analyses of antiviral drugs with MALDI-MS/MS

2010-07-09T19:19:00Z

Roland Meesters, Jeroen van Kampen, Lennard Dekker, Marleen Reedijk, Rachel Schreuer, David Burger, Ab Osterhaus, Theo Luider and Rob Gruters (2009) FIGON 2009 Dutch Medicine Days, Lunteren-the Netherlands, October 12-14, 2009

Toepassing van massa spectrometrie in de klinische chemie“diagnostiek m.b.v. MALDI-MS/MS bij HIV-geinfecteerde patienten”

2010-07-09T19:29:42Z

Roland J.W. Meesters (2009) OLVG Hospital, Amsterdam-the Netherlands,September 10, 2009

Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?

2010-09-02T19:02:23Z

1. The cytochrome P450-mediated metabolism of the tea tree oil ingredient p-cymene (p-isopropyltoluene) was studied by the application of in vitro enzymatic assays using different recombinant human cytochrome P450 enzymes. 2. In total, four enzymatic products were identified by gas chromatography-mass spectrometry. The enzymatic products identified were: thymol (2-isopropyl-5-methylphenol), p-isop...

R J W Meesters, M Duisken, J Hollender (2009) Xenobiotica 39: 9 663-671

Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates.

2010-07-11T07:22:07Z

A method was developed for the determination of the monoterpene alcohols verbenol, myrtenol, perillyl alcohol, alpha-terpineol, Delta(3)-carene-10-ol, thymol and p-alpha,alpha-trimethylbenzylalcohol in urine samples. After an enzymatic cleavage of their glucuronide- and sulfate conjugates the monoterpene alcohols were converted in the urine matrix with 7-diethylaminocoumarin-3-carbonylazide into m...

Roland J W Meesters, Mike Duisken, Heike Jähnigen, Juliane Hollender (2008) J Chromatogr B Analyt Technol Biomed Life Sci 875: 2 444-450

Application of liquid chromatography-mass spectrometry to measure the concentrations and study the synthesis of short chain fatty acids following stable isotope infusions.

2008-05-17T02:16:59Z

A new method involving zinc sulphate deproteinization was developed to study short chain fatty acids (SCFA) production in the colon and subsequent occurrence of SCFA in blood. SCFA were baseline separated in a 30 min cycle using ion-exclusion chromatography and detected by mass spectrometry. Concentrations could be measured down to 10 microM and isotopomeric distributions could be assessed, enabli...

R J W Meesters, H M H van Eijk, G A M ten Have, A A de Graaf, K Venema, B E J van Rossum, N E P Deutz (2007) J Chromatogr B Analyt Technol Biomed Life Sci 854: 1-2 57-62

Study on the cytochrome P450-mediated oxidative metabolism of the terpene alcohol linalool: indication of biological epoxidation.

2008-05-17T02:16:59Z

The cytochrome P450-mediated oxidative metabolism of the terpene alcohol linalool was studied in vitro by enzymatic assays using recombinant human cytochrome P450 enzymes. Three different enzymatic products of allylic hydroxylation and epoxidation were identified by gas chromatography-mass spectrometry. Identified enzymatic products were 8-hydroxylinalool ((R/S)-3,7-dimethyl-1,6-octadiene-3,8-diol...

R J W Meesters, M Duisken, J Hollender (2007) Xenobiotica 37: 6 604-617

Contribution to the detection and identification of oxidation metabolites of nonylphenol in Sphingomonas sp. strain TTNP3

2008-05-17T16:26:45Z

Sphingomonas sp. strain TTNP3 has been previously described as a bacterium that is capable of degrading the technical mixture of nonylphenol (NP) isomers and also the 4(3′,5′-dimethyl-3′-heptyl)-phenol single isomer of NP. Until recently, 3,5-dimethyl-3-heptanol was the only reported metabolite of 4(3′,5′-dimethyl-3′-heptyl)-phenol. A short time ago, the detection of an intracellular m...

P.F.X. Corvini, R. Meesters , M. Nundt, A. Schaeffer, B. Schmidt, H.Fr. Schröder, W. Verstraete, R. Vinken, J. Hollender (2007) Biodegradation 18: 233-245

Concentration and distribution of organochlorine pesticides in surface water and sediments in lake Volvi (N. Greece).

2008-05-17T16:27:47Z

The objective of the study was to monitor the occurrence of a wide range of OCPs and sediments of the Lake Volvi in northern Greece and to determine their temporal and spatial variations. The samples have been collected seasonally for a period of one year. Solid-phase extraction followed by gas-chromatographic techniques with electron-capture detection was used for the determination of the compoun...

Fytianos K., Meesters R.J.W., Schroeder H. Fr., Gouliarmou B., Gantidis N (2006) Inter. J. Environ, Anal. Chem. 2006 86: 109-118

Elucidation of the metabolism of the monoterpenes Linalool and p-cymene by recombinant human cytochrome P450 enzymes

2008-11-15T17:11:20Z

(2006)

Stability of fluorinated surfactants in advanced oxidation processes--A follow up of degradation products using flow injection-mass spectrometry, liquid chromatography-mass spectrometry and liquid chromatography-multiple stage mass spectrometry.

2008-05-17T02:16:59Z

The advanced oxidation process (AOP) reagents ozone (O3), O3/UV, O3/H2O2, and H2O2/Fe2+ (Fenton's reagent) were applied to the anionic and the non-ionic fluorinated surfactants perfluorooctanesulfonate (PFOS) and N-ethyl-N-(perfluoroalkyl)-sulfonyl-glycinic acid (HFOSA-glycinic acid) or N-ethyl-N-perfluoroalkyl sulfonylamido-2-ethanol polyethoxylates (NEtFASE-PEG), their methyl ethers (NEtFASE-PEG...

Horst F Schröder, Roland J W Meesters (2005) J Chromatogr A 1082: 1 110-119

Sorption, volatilisation and biodegradation of trace pollutants in conventional aeration tanks and in membrane bioreactors.

2010-07-09T19:05:27Z

Ivashechkin, P., Corvini, P. F. X., Fahrbach, M., Hollender, J., Konietzko, M., Meesters, R., Schröder, H. F., and Dohmann, M. (2005) Conference proceedings of the First IWA National Young Researches Conference "Emerging Pollutants" (NYRC 2005) 27-28.10.2005 Aachen (Germany)

Microbial degradation of a single branched isomer of nonylphenol by Sphingomonas TTNP3

2008-05-17T16:28:14Z

The endocrine disrupting chemical nonylphenol (NP) is a technical product which consists of a complex mixture of nonylphenols with different alkyl side-chain isomers. Since the bio-degradation of each NP isomer may lead to its own range of metabolites, the isolation and identification of transformation products is very difficult. In order to overcome this difficulty, the nonylphenol isomer 4(3',5'...

P.F.X. Corvini, R. Vinken, G. Hommes, M. Mundt, R. Meesters, H.F. Schröder, J. Hollender, B. Schmidt (2004) Water Sci Technol 50: 189-194

Mass spectrometric analytical methods for the determination of endocrine disrupting chemicals (EDCs).

2008-05-17T02:16:59Z

This paper describes a method for the determination of endocrine disrupting chemicals (EDCs) in waste water. The method involves a SPE-C18 extraction followed by a SPE-silica gel column clean up and elution of the analytes with a mixture of acetone/pentane (2+1). Thereafter derivatisation of the analytes with heptafluorobutyric acid anhydride (HFBA) and analysis by gas chromatography/mass spectrom...

A Stehmann, R J W Meesters, Horst Fr Schröder (2004) Water Sci Technol 50: 5 165-171

Degradation of a nonylphenol single isomer by Sphingomonas sp. strain TTNP3 leads to a hydroxylation-induced migration product.

2008-05-17T02:16:59Z

Sphingomonas sp. strain TTNP3 degrades 4(3',5'-dimethyl-3'-heptyl)-phenol and unidentified metabolites that were described previously. The chromatographic analyses of the synthesized reference compound and the metabolites led to their identification as 2(3',5'-dimethyl-3'-heptyl)-1,4-benzenediol. This finding indicates that the nonylphenol metabolism of this bacterium involves unconventional degra...

P F X Corvini, R J W Meesters, A Schäffer, H F Schröder, R Vinken, J Hollender (2004) Appl Environ Microbiol 70: 11 6897-6900

sorption, volatilization and biodegradation of trace pollutants in conventional aeration tanks and in membrane bioreactors

2010-07-09T19:05:43Z

P.Ivashechkin, P.F.X. Corvini, M.Farbach, J.Hollender, M. Konietzko, R.J.W.Meesters, H.Fr. Schroeder and M.Dohman (2004) IWA first Natinal young researchers conference” Emerging pollutants”, 2005, 27-28 october, Aachen, Germany

Perfluorooctane sulfonate--a quite mobile anionic anthropogenic surfactant, ubiquitously found in the environment.

2008-05-17T02:16:59Z

The biochemical degradation of perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) under aerobic and anaerobic conditions in closed-loop systems was monitored in laboratory scale. Adsorptive effects of these compounds to glass and polypropylene were also examined. Liquid chromatography/mass spectrometry (LC-MS) under negative electrospray (ESI(-)) conditions was applied for determina...

R J W Meesters, H Fr Schröder (2004) Water Sci Technol 50: 5 235-242

Risk-assesment of Kathon in waterborne paint products

2008-11-15T16:56:27Z

(2004)

Simultaneous determination of 4-nonylphenol and bisphenol A in sewage sludge.

2008-05-17T02:16:59Z

An analytical method has been developed for simultaneous extraction and determination of two estrogenic active agents, 4-nonylphenol (4-NP) and bisphenol A (BPA), in activated sewage sludge and anaerobically stabilized sewage sludge. Both compounds were determined by GC/MS in freeze-dried sewage sludge samples that had been spiked with these compounds in order to indicate different contamination l...

Roland J W Meesters, Horst Fr Schröder (2002) Anal Chem 74: 14 3566-3574

The fate of Atrazine and Simazine in the drinking water treatment process using ozone and ozone/UV

2008-05-17T00:34:25Z

Meesters R.J.W., Forge F., Schroeder H.Fr. (1995) Vom Wasser 84: 287-300

The fate of atrazine and simazine in the drinking water treatment process using ozone and ozone/uv

2008-11-15T16:59:23Z

(1994)

2011-03-31T06:28:03Z

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