http://publicationslist.org/data/s.berkov/atom.xml Strahil Berkovhttp://publicationslist.org/s.berkov$basepathfavicon.icoRecent additions to Strahil Berkov's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-03-18T17:57:53Z http://publicationslist.org/s.berkov/refid1 2010-03-18T17:52:08Z

INTRODUCTION: Pancratium canariense Ker Gawler is a plant species belonging to family Amaryllidaceae. Plants from this family are known to synthesise a particular type of bioactive compounds, named Amaryllidaceae alkaloids, which have shown AChE inhibitory activity. OBJECTIVE: To perform the metabolite profiling of methanolic extracts from P. canariense in order to identify bioactive compounds. ME...<br/><br/>Laura Torras-Claveria, Strahil Berkov, Olga Jáuregui, Juli Caujapé, Francesc Viladomat, Carles Codina, Jaume Bastida (2010) <i>Phytochem Anal</i> <i></i> <i></i> 21: 1 80-88<br/>

http://publicationslist.org/s.berkov/refid3 2010-03-18T17:52:08Z

The common effect of NH4+, NO3-, KH2PO4 and sucrose on the biosynthesis of galanthamine by a Leucojum aestivum shoot culture was studied. Polynominal regression models were elaborated for the description of the galanthamine biosynthesis as a consequence of variation of the investigated variables (NH4+ between 0.20 and 0.54 g/L; NO3- between 1.44 and 3.44 g/L; KH2PO4 between 0.10 and 0.24 g/L, and ...<br/><br/>Vasil Georgiev, Strahil Berkov, Milen Georgiev, Monique Burrus, Carles Codina, Jaume Bastida, Mladenka Ilieva, Atanas Pavlov (2009) <i>Z Naturforsch C</i> <i></i> <i></i> 64: 3-4 219-224<br/>

http://publicationslist.org/s.berkov/refid6 2010-03-18T17:52:08Z

Hyoscyamine biosynthesis in Datura stramonium hairy roots with different ploidy levels was investigated. For the first time, we report that hairy roots undergo endoreduplication and therefore consist mainly of cells with doupled sets of chromosomes of primary plant tissues, used for Agrobacterium transformation. The alkaloid profiles of hairy roots obtained from diploid and tetraploid plants were ...<br/><br/>A Pavlov, S Berkov, J Weber, Th Bley (2009) <i>Appl Biochem Biotechnol</i> <i></i> <i></i> 157: 2 210-225<br/>

http://publicationslist.org/s.berkov/refid5 2010-03-18T17:52:08Z

Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3',3'',3'''-trihydroxybutanoyl)hamayne, 8-O-demethylvasconine, tazettine, epimacron...<br/><br/>Strahil Berkov, María Cuadrado, Edison Osorio, Francesc Viladomat, Carles Codina, Jaume Bastida (2009) <i>Planta Med</i> <i></i> <i></i> 75: 12 1351-1355<br/>

http://publicationslist.org/s.berkov/refid2 2010-03-18T17:52:08Z

Twenty-one alkaloids and related compounds were found in Sternbergia colchiciflora (Amaryllidaceae), a hitherto not studied plant species. Twenty of them were detected by GC-MS in the crude extracts of this plant species. Ten alkaloids were isolated and their structures confirmed by NMR, MS and CD measurements. Many of the compounds found in this species, such as lycorine, tazettine, haemanthidine...<br/><br/>Strahil Berkov, Jaume Bastida, Reneta Tsvetkova, Francesc Viladomat, Carles Codina (2009) <i>Z Naturforsch C</i> <i></i> <i></i> 64: 5-6 311-316<br/>

http://publicationslist.org/s.berkov/refid4 2010-03-18T17:52:08Z

The alkaloids of intact plants, calli and shoot-clump cultures of L. aestivum were analyzed by GC-MS. Twenty-four alkaloids were detected. Calli appeared to produce sparse alkaloid profiles in stark contrast to shoot-clumps that had similar profiles to those of the intact plant. Seven shoot-clump strains produced galanthamine predominantly whereas another three were dominated by lycorine. Shoot-cl...<br/><br/>Strahil Berkov, Atanas Pavlov, Vasil Georgiev, Jaume Bastida, Monique Burrus, Mladenka Ilieva, Carles Codina (2009) <i>Nat Prod Commun</i> <i></i> <i></i> 4: 3 359-364<br/>

http://publicationslist.org/s.berkov/refid7 2010-03-18T17:52:08Z

Alkaloid extracts from 12 plant species of the families Amaryllidaceae, Fumariacae and Papaveraceae were studied with respect to their acetylcholinesterase inhibitory activity and alkaloid patterns. Fifty-three alkaloids were identified by GC-MS, including known acetylcholinesterase (AChE) inhibitors such as galanthamine, epigalanthamine, sanguinine and epinorgalanthamine in extracts of Amaryllida...<br/><br/>Strahil Berkov, Jaume Bastida, Milena Nikolova, Francesc Viladomat, Carles Codina (2008) <i>Phytochem Anal</i> <i></i> <i></i> 19: 5 411-419<br/>

http://publicationslist.org/s.berkov/refid8 2010-03-18T17:52:08Z

Galanthamine, an acetylcholinesterase inhibitor used for the treatment of Alzheimer's disease, and galanthamine-type alkaloids are synthesised in different plants of the family Amaryllidaceae. A capillary gas chromatographic-mass spectroscopic (CGC-MS) method for the separation of 7 galanthamine type alkaloids, including galanthamine and epigalanthamine, is described in the present paper. A simple...<br/><br/>Strahil Berkov, Jaume Bastida, Francesc Viladomat, Carles Codina (2008) <i>Phytochem Anal</i> <i></i> <i></i> 19: 4 285-293<br/>

http://publicationslist.org/s.berkov/refid9 2010-03-18T17:52:08Z

N-(14-Methylallyl)norgalanthamine, a new natural compound, together with five known alkaloids: N-allylnorgalanthamine, galanthamine, epinorgalanthamine, narwedine, and lycorine were isolated from mother liquors (waste material) obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves. The structures of N-allylnorgalanthamine and N-(14-methylallyl)norgalantham...<br/><br/>Strahil Berkov, Carles Codina, Francesc Viladomat, Jaume Bastida (2008) <i>Bioorg Med Chem Lett</i> <i></i> <i></i> 18: 7 2263-2266<br/>

http://publicationslist.org/s.berkov/refid10 2010-03-18T17:52:08Z

Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s...<br/><br/>Liliya Georgieva, Strahil Berkov, Violeta Kondakova, Jaume Bastida, Francesc Viladomat, Atanas Atanassov, Carles Codina (2007) <i>Z Naturforsch C</i> <i></i> <i></i> 62: 9-10 627-635<br/>

http://publicationslist.org/s.berkov/refid14 2010-03-18T17:57:00Z

Phytochemical studies on Galanthus nivalis of Bulgarian origin resulted in the isolation of five compounds: 11-O-(3'-hydroxybutanoyl)hamayne, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3-O-(2''-butenoyl)-11-O-(3'-hydroxybutanoyl)hamayne, 3,11,3''-O-(3',3'',3'''-trihydroxybutanoyl)hamayne, and 2-O-(3'-acetoxybutanoyl)lycorine, together with five known alkaloids: ungeremine, lycorine, tazettine, hama...<br/><br/>Strahil Berkov, Carles Codina, Francesc Viladomat, Jaume Bastida (2007) <i>Phytochemistry</i> <i></i> <i></i> 68: 13 1791-1798<br/>

http://publicationslist.org/s.berkov/refid13 2010-03-18T17:57:00Z

Phytochemical studies on Galanthus elwesii resulted in the isolation of five alkaloids: incartine, hordenine, hippeastrine, 8-O-demethylhomolycorine and lycorine. The NMR data given previously for incartine were revised and completed by two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments. In vitro studies on the bioactivity of incartine were carried out.<br/><br/>Strahil Berkov, Ricardo Reyes-Chilpa, Carles Codina, Francesc Viladomat, Jaume Bastida (2007) <i>Molecules</i> <i></i> <i></i> 12: 7 1430-1435<br/>

http://publicationslist.org/s.berkov/refid15 2010-03-18T17:57:00Z

A comparative GC-MS investigation of the alkaloid patterns of three varieties of Datura stramonium vars. stramonium, tatula and godronii, was carried out. Twenty-five tropane alkaloids were identified in the plant organs. Alkaloid patterns of the roots, leaves and seeds of the varieties grown at equal conditions in Bulgaria were very similar. In contrast, alkaloid pattern of D. stramonium var. str...<br/><br/>Strahil Berkov, Rawia Zayed, Tsvetelina Doncheva (2006) <i>Fitoterapia</i> <i></i> <i></i> 77: 3 179-182<br/>

http://publicationslist.org/s.berkov/refid16 2010-03-18T17:57:00Z

Underivatised alkaloid mixtures extracted from intact plants and in vitro cultures of Leucojum aestivum (Amaryllidaceae) were investigated by capillary GC-MS. Excellent peak resolution for the alkaloids was exhibited and isomers of galanthamine and N-formylnorgalanthamine were well separated. Fourteen alkaloids of galanthamine, lycorine and crinane types were identified, 11 in the intact plants an...<br/><br/>Strahil Berkov, Atanas Pavlov, Mladenka Ilieva, Monique Burrus, Simeon Popov, Marina Stanilova (2005) <i>Phytochem Anal</i> <i></i> <i></i> 16: 2 98-103<br/>

http://publicationslist.org/s.berkov/refid20 2010-03-18T17:57:00Z

Alkaloid pattern of individuals from 16 Bulgarian Galanthus elwesii populations was investigated by GC/MS and TLC. Twenty-one Amaryllidaceae alkaloids were detected and 14 of them were identified. Crinane type alkaloids, haemanthamine or crinine, dominated alkaloid metabolism in most of the populations. With exception of one population, where the separate individuals showed variable alkaloid profi...<br/><br/>Strahil Berkov, Borjana Sidjimova, Luba Evstatieva, Simeon Popov (2004) <i>Phytochemistry</i> <i></i> <i></i> 65: 5 579-586<br/>

http://publicationslist.org/s.berkov/refid19 2010-03-18T17:57:00Z

A GC/MS analysis of alkaloids from leaves, bulbs and roots of Pancratium maritimum was performed. From the identified 16 alkaloids, 5 alkaloids were reported for the first time for this plant. Several compounds with pharmacological activity were found. Haemanthamine was main alkaloid in the leaves and bulbs whereas galanthane was found to be main alkaloid in roots.<br/><br/>Strahil Berkov, Luba Evstatieva, Simeon Popov (2004) <i>Z Naturforsch C</i> <i></i> <i></i> 59: 1-2 65-69<br/>

http://publicationslist.org/s.berkov/refid17 2010-03-18T17:57:00Z

The alkaloid spectra of Datura innoxia plants grown in Egypt and Bulgaria were investigated by GC-MS. Thirty-eight alkaloids were detected in the roots, leaves and fruits of the plants. Five new alkaloids for D. innoxia are reported. Alkaloid spectra of Egyptian and Bulgarian plants differ significantly in respect to their alkaloid composition and main alkaloids accumulated in the plant organs.<br/><br/>Strahil Berkov, Rawia Zayed (2004) <i>Z Naturforsch C</i> <i></i> <i></i> 59: 3-4 184-186<br/>

http://publicationslist.org/s.berkov/refid18 2010-03-18T17:57:00Z

A rapid and convenient method for sample preparation and simultaneous densitometric quantification of hyoscyamine (1) and scopolamine (2) has been developed. The alkaloid profiles of plant samples, as well as the content of 1 and 2, determined by TLC-densitometry corresponded well with those obtained using a GC method. The proposed method is simple and sensitive and can be used for the routine ass...<br/><br/>Strahil Berkov, Atanas Pavlov (2004) <i>Phytochem Anal</i> <i></i> <i></i> 15: 3 141-145<br/>

http://publicationslist.org/s.berkov/refid22 2010-03-18T17:57:00Z

Thirty-six alkaloids were identified in the organs of Datura ceratocaula by GC/MS. Thirty-three of them have not been previously reported for the species. Furthermore, a new tropane ester was tentatively identified as 3-(3'-formyloxytropoyloxy)tropane on basis of its mass spectral fragmentation. Hyoscyamine was the main alkaloid in the plant organs.<br/><br/>Strahil Berkov (2003) <i>Z Naturforsch C</i> <i></i> <i></i> 58: 7-8 455-458<br/>

http://publicationslist.org/s.berkov/refid21 2010-03-18T17:57:00Z

Sixteen populations of Galanthus elwesii Hook.fil and five populations of Galanthus nivalis L. growing in Bulgaria were investigated for the presence of galanthamine by TLC and GC-MS. Between 3 and 11 alkaloids were detected by TLC in the total alkaloid fractions. Galanthamine was found in 2 populations of G. elwesii.<br/><br/>B Sidjimova, S Berkov, S Popov, L Evstatieva (2003) <i>Pharmazie</i> <i></i> <i></i> 58: 12 935-936<br/>

http://publicationslist.org/s.berkov/refid11 2010-03-18T17:54:08Z

Hairy root cultures were obtained from diploid and induced tetraploid plants of Datura stramonium and analyzed by gas chromatography/mass spectrometry. Twenty alkaloids (19 for diploid and 9 for tetraploid hairy root cultures) were identified. A new tropane ester 3-tigloyloxy-6-propionyloxy-7-hydroxytropane was identified on the basis of mass spectral data. Hyoscyamine was the main alkaloid in bot...<br/><br/>Strahil Berkov, Atanas Pavlov, Petia Kovatcheva, Pepa Stanimirova, Stefan Philipov (2003) <i>Z Naturforsch C</i> <i></i> <i></i> 58: 1-2 42-46<br/>

http://publicationslist.org/s.berkov/refid12 2010-03-18T17:54:08Z

Alkaloids, GS-MS, Datura stramonium The alkaloid spectrum in roots, leaves and seeds of Datura stramonium L. was investigated by GC-MS. Twenty-nine tropane alkaloids are detected. Twelve of them are new constituents for the species and the two tropane esters 3-(3'-acetoxytropoyloxy)tropane (21) and 3-(2'-hydroxytropoyloxy)tropane (26) are described for the first time.<br/><br/>Stefan Philipov, Strahil Berkov (2002) <i>Z Naturforsch C</i> <i></i> <i></i> 57: 5-6 559-561<br/>