http://publicationslist.org/data/s.ott/atom.xml Stephan Otthttp://publicationslist.org/s.ott$basepathfavicon.icoRecent additions to Stephan Ott's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-10-16T12:21:10Z http://publicationslist.org/s.ott/refid3 2009-10-16T12:04:50Z

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a histologically distinct tumour derived from MALT acquired as a result of Helicobacter pylori infection. The genetic susceptibility to develop primary gastric B-cell lymphoma in patients with chronic H. pylori infection is unknown. MALT1 plays a key role in malignant B-cell transformation and lymphoma progression. Thus, we investigated ...<br/><br/>Stephan Hellmig, Tobias Bartscht, Wolfgang Fischbach, Stephan Johannes Ott, Philip Rosenstiel, Wolfram Klapper, Ulrich Robert Fölsch, Stefan Schreiber (2009) <i>Eur J Cancer</i> <i></i> <i></i> 45: 10 1865-1870<br/>

http://publicationslist.org/s.ott/refid20 2009-10-16T12:13:33Z

A strictly anaerobic, Gram-positive, short-rod/coccobacillus-shaped bacterial strain, designated 7-10-1-b(T), was isolated from the colon of a patient suffering from acute Crohn's disease. The isolate formed small, pale-white, semi-translucent colonies on solid cultivation media. The strain was catalase-positive and metabolized only a small number of carbon sources. Whole-cell fatty acids consiste...<br/><br/>Dieco Würdemann, Brian J Tindall, Rüdiger Pukall, Heinrich Lünsdorf, Carsten Strömpl, Theresa Namuth, Hannes Nahrstedt, Melissa Wos-Oxley, Stephan Ott, Stephan Schreiber, Kenneth N Timmis, Andrew P A Oxley (2009) <i>Int J Syst Evol Microbiol</i> 59: Pt 6 1405-1415<br/>

http://publicationslist.org/s.ott/refid2 2009-10-16T12:04:50Z

S Hellmig, K Troch, S J Ott, U R Fölsch, T Schwarz (2009) <i>Clin Exp Dermatol</i> <i></i> <i></i> 34: 7 <br/>

http://publicationslist.org/s.ott/refid1 2009-10-16T12:04:50Z

OBJECTIVE: Plaque accumulation on implant surfaces can result in peri-implantitis with potential implant loss. The aim of the present study was to examine the influence of zirconium nitride (ZrN) as a potential implant surface on the biofilm composition and diversity in vivo. MATERIAL AND METHODS: ZrN- or titanium (Ti)-coated glass specimens and ZrN or roughened Ti discs were used as substrates. P...<br/><br/>Birte Grössner-Schreiber, Jan Teichmann, Matthias Hannig, Christof Dörfer, Dirk F Wenderoth, Stephan J Ott (2009) <i>Clin Oral Implants Res</i> <i></i> <i></i> 20: 8 817-826<br/>

http://publicationslist.org/s.ott/refid4 2009-10-16T12:04:50Z

INTRODUCTION: Chronic urticaria is thought to have numerous causative factors including a large variety of infectious conditions, food intake, and drugs. The impact of Helicobacter pylori infection has been studied with ambiguous results. The aim of this study was to investigate the course of chronic urticaria in H. pylori-positive patients undergoing eradication compared to H. pylori-negative urt...<br/><br/>S Hellmig, K Troch, S J Ott, T Schwarz, U R Fölsch (2008) <i>Helicobacter</i> <i></i> <i></i> 13: 5 341-345<br/>

http://publicationslist.org/s.ott/refid7 2009-10-16T12:04:50Z

OBJECTIVE: Altered bacterial diversity of the intestinal mucosa-associated microbiota may reflect the net influence of lifestyle factors associated with the development of chronic inflammatory bowel diseases (IBD). While a reduced bacterial diversity has been reported in IBD, little is known about the fungal microbiota. The aim of this study was to carry out a systematic analysis of intestinal fun...<br/><br/>Stephan J Ott, Tanja Kühbacher, Meike Musfeldt, Philip Rosenstiel, Stephan Hellmig, Ateequr Rehman, Oliver Drews, Wilko Weichert, Kenneth N Timmis, Stefan Schreiber (2008) <i>Scand J Gastroenterol</i> <i></i> <i></i> 43: 7 831-841<br/>

http://publicationslist.org/s.ott/refid6 2009-10-16T12:04:50Z

The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time.<br/><br/>Stephan J Ott, Sophie Plamondon, Ailsa Hart, Alexander Begun, Ateequr Rehman, Michael A Kamm, Stefan Schreiber (2008) <i>J Clin Microbiol</i> <i></i> <i></i> 46: 10 3510-3513<br/>

http://publicationslist.org/s.ott/refid5 2009-10-16T12:04:50Z

TM7 is a recently described subgroup of Gram-positive uncultivable bacteria originally found in natural environmental habitats. An association of the TM7 bacterial division with the inflammatory pathogenesis of periodontitis has been previously shown. This study investigated TM7 phylogenies in patients with inflammatory bowel diseases (IBDs). The mucosal microbiota of patients with active Crohn's ...<br/><br/>Tanja Kuehbacher, Ateequr Rehman, Patricia Lepage, Stephan Hellmig, Ulrich R Fölsch, Stefan Schreiber, Stephan J Ott (2008) <i>J Med Microbiol</i> <i></i> <i></i> 57: Pt 12 1569-1576<br/>

http://publicationslist.org/s.ott/refid21 2009-10-16T12:15:16Z

B Flesch, J Miller, R Repp, S Ott, B Gahn, N Schub, M Gramatzki, A Humpe (2008) <i>Bone Marrow Transplant</i> 42: 7 489-491<br/>

http://publicationslist.org/s.ott/refid9 2009-10-16T12:04:50Z

BACKGROUND: Bacterial DNA has been repeatedly detected in atheromatous lesions of coronary heart disease (CHD) patients. Phylogenetic signatures in the atheroma lesions that are similar to those of bacterial biofilms on human barrier organs, including the respiratory or gastrointestinal tract, raise the question of a defective barrier function in CHD. NOD2 plays a major role in defense against bac...<br/><br/>Nour Eddine El Mokhtari, Stephan J Ott, Almut Nebel, Arne Schäfer, Philip Rosenstiel, Matti Förster, Michael Nothnagel, Rüdiger Simon, Stefan Schreiber (2007) <i>BMC Genet</i> <i></i> <i></i> 8: <br/>

http://publicationslist.org/s.ott/refid8 2009-10-16T12:04:50Z

Bacterial DNA has been found in coronary plaques and it has therefore been concluded that bacteria may play a role as trigger factors in the chronic inflammatory process underlying coronary atherosclerosis. However, the microbial spectrum is complex and it is not known whether microorganisms other than bacteria are involved in coronary disease. Fungal 18S rDNA signatures were systematically invest...<br/><br/>Stephan J Ott, Nour Eddine El Mokhtari, Ateequr Rehman, Philip Rosenstiel, Stephan Hellmig, Tanja Kühbacher, Markus Lins, Rüdiger Simon, Stefan Schreiber (2007) <i>Environ Microbiol</i> <i></i> <i></i> 9: 12 3035-3045<br/>

http://publicationslist.org/s.ott/refid22 2009-10-16T12:15:50Z

BACKGROUND: Chlamydophila pneumoniae is an obligate intracellular bacterium that replicates in a biphasic life cycle within eukaryotic host cells. Four published genomes revealed an identity of > 99 %. This remarkable finding raised questions about the existence of distinguishable genotypes in correlation with geographical and anatomical origin. RESULTS: We studied the genetic diversity of C. pneu...<br/><br/>Thomas Rattei, Stephan Ott, Michaela Gutacker, Jan Rupp, Matthias Maass, Stefan Schreiber, Werner Solbach, Thierry Wirth, Jens Gieffers (2007) <i>BMC Genomics</i> 8: <br/>

http://publicationslist.org/s.ott/refid14 2009-10-16T12:05:30Z

BACKGROUND: The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. However, the mechanism by which therapy with probiotics works remains elusive. This...<br/><br/>T Kühbacher, S J Ott, U Helwig, T Mimura, F Rizzello, B Kleessen, P Gionchetti, M Blaut, M Campieri, U R Fölsch, M A Kamm, S Schreiber (2006) <i>Gut</i> <i></i> <i></i> 55: 6 833-841<br/>

http://publicationslist.org/s.ott/refid12 2009-10-16T12:05:30Z

BACKGROUND AND STUDY AIM: Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colonic dysplasias. Dysplastic changes in flat mucosa are likely to be missed by conventional colonoscopy. Endoscopic fluorescence imaging, using 5-aminolevulinic acid (5-ALA) as photosensitizer, has evolved as a new technique to differentiate between normal colonic mucosa an...<br/><br/>T Ochsenkühn, C Tillack, H Stepp, J Diebold, S J Ott, R Baumgartner, S Brand, B Göke, M Sackmann (2006) <i>Endoscopy</i> <i></i> <i></i> 38: 5 477-482<br/>

http://publicationslist.org/s.ott/refid10 2009-10-16T12:04:50Z

Infection and innate immunity have been suggested as playing an important role in the pathogenesis of atherosclerosis. The recently discovered pattern-recognition receptor (PRR) proteins initiate signalling after host-pathogen interactions and several PRRs, especially the Toll-like receptor 4 (TLR4), have been shown to be involved in the development and progression of atherosclerosis. A new additi...<br/><br/>N E El Mokhtari, S J Ott, A Nebel, R Simon, S Schreiber (2006) <i>Int J Immunogenet</i> <i></i> <i></i> 33: 4 307-311<br/>

http://publicationslist.org/s.ott/refid13 2009-10-16T12:05:30Z

BACKGROUND: Bacterial infection has been discussed as a potential etiologic factor in the pathophysiology of coronary heart disease (CHD). This study analyzes molecular phylogenies to systematically explore the presence, frequency, and diversity of bacteria in atherosclerotic lesions in patients with CHD. METHODS AND RESULTS: We investigated 16S rDNA signatures in atherosclerotic tissue obtained t...<br/><br/>Stephan J Ott, Nour Eddine El Mokhtari, Meike Musfeldt, Stephan Hellmig, Sandra Freitag, Ateequr Rehman, Tanja Kühbacher, S Nikolaus, Pawel Namsolleck, Michael Blaut, Jochen Hampe, Hany Sahly, Alexander Reinecke, Nils Haake, Rainer Günther, Dietmar Krüger, Markus Lins, Gunhild Herrmann, Ulrich R Fölsch, Rüdiger Simon, Stefan Schreiber (2006) <i>Circulation</i> <i></i> <i></i> 113: 7 929-937<br/>

http://publicationslist.org/s.ott/refid26 2009-10-16T12:16:57Z

We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronic Helicobacter pylori infection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.0...<br/><br/>Stephan Hellmig, Frank Gieseler, Stephan Ott, Phillip Rosenstiel, Wolfgang Fischbach, Ulrich Robert Fölsch, Stefan Schreiber (2006) <i>Cancer Lett</i> <i></i> <i></i> 238: 2 295-303<br/>

http://publicationslist.org/s.ott/refid24 2009-10-16T12:16:23Z

Host immune response influences the clinical outcome of Helicobacter pylori infection leading to ulcer disease, gastric carcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. A genetic risk profile for gastric cancer has been identified, but genetic susceptibility to develop MALT lymphoma is still unclear. We investigated the role of NOD1 and NOD2 as intracellular recognition molecules f...<br/><br/>Philip Rosenstiel, Stephan Hellmig, Jochen Hampe, Stefan Ott, Andreas Till, Wolfgang Fischbach, Hany Sahly, Ralph Lucius, Ulrich R Fölsch, Dana Philpott, Stefan Schreiber (2006) <i>Cell Microbiol</i> <i></i> <i></i> 8: 7 1188-1198<br/>

http://publicationslist.org/s.ott/refid25 2009-10-16T12:16:57Z

BACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) are a family of enzymes that degrade most of the macromolecules making up the extracellular matrix. H. pylori infection increases the secretion of MMPs in the gastric mucosa leading to severe mucosal damage. The aim of this study was to investigate if genetic variants in MMPs involved in the inflammatory response to H. pylori could predispose p...<br/><br/>Stephan Hellmig, Stefan Ott, Phillip Rosenstiel, Ulrich Robert Fölsch, Jochen Hampe, Stefan Schreiber (2006) <i>Am J Gastroenterol</i> <i></i> <i></i> 101: 1 29-35<br/>

http://publicationslist.org/s.ott/refid11 2009-10-16T12:05:30Z

S J Ott, S Schreiber (2006) <i>Gut</i> <i></i> <i></i> 55: 8 <br/>

http://publicationslist.org/s.ott/refid23 2009-10-16T12:16:23Z

To investigate the effect of long-term consumption of probiotic bacteria on viral respiratory tract infections (common cold, influenza), a randomized, double blind, controlled intervention study was performed during two winter/spring periods (3 and 5 month). Four hundred and seventy-nine healthy adults were supplemented daily with vitamins plus minerals with or without probiotic lactobacilli and b...<br/><br/>Michael de Vrese, Petra Winkler, Peter Rautenberg, Timm Harder, Christian Noah, Christiane Laue, Stephan Ott, Jochen Hampe, Stefan Schreiber, Knut Heller, Jürgen Schrezenmeir (2006) <i>Vaccine</i> <i></i> <i></i> 24: 44-46 6670-6674<br/>

http://publicationslist.org/s.ott/refid28 2009-10-16T12:16:57Z

BACKGROUND & AIMS: The aim of this study was to investigate whether the consumption of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 (5 x 10(7) cfu/tablet) during at least 3 months influences the severity of symptoms and the incidence and duration of the common cold. METHODS: A randomized, double-blind, placebo-controlled intervention study was performed over at...<br/><br/>Michael de Vrese, Petra Winkler, Peter Rautenberg, Timm Harder, Christian Noah, Christiane Laue, Stephan Ott, Jochen Hampe, Stefan Schreiber, Knut Heller, Jürgen Schrezenmeir (2005) <i>Clin Nutr</i> <i></i> <i></i> 24: 4 481-491<br/>

http://publicationslist.org/s.ott/refid27 2009-10-16T12:16:57Z

Chronic diarrheal illness and malabsorption are challenging diagnostic and clinical problems. The identification of the causative pathogens that are involved in gastrointestinal infections is often difficult. It took 85 years after the first description of a case of intestinal lipodystrophy by Georg Whipple in 1907 until the causative bacterium was characterized by using molecular genetics techniq...<br/><br/>Stephan Hellmig, Stephan Ott, Meike Musfeldt, Markus Kosmahl, Phillip Rosenstiel, Eckhard Stüber, Jochen Hampe, Ulrich R Fölsch, Stefan Schreiber (2005) <i>Gastroenterology</i> <i></i> <i></i> 129: 2 706-712<br/>

http://publicationslist.org/s.ott/refid29 2009-10-16T12:17:25Z

BACKGROUND AND AIMS: Chronic H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1beta and its natural receptor antagonist IL-1ra are involved in the inflammatory response to H. pylor...<br/><br/>Stephan Hellmig, Andrea Titz, Stefanie Steinel, Stephan Ott, Ulrich Robert Fölsch, Jochen Hampe, Stefan Schreiber (2005) <i>Immunol Lett</i> 100: 2 107-112<br/>

http://publicationslist.org/s.ott/refid17 2009-10-16T12:05:30Z

BACKGROUND AND AIMS: The intestinal bacterial microflora plays an important role in the aetiology of inflammatory bowel disease (IBD). As most of the colonic bacteria cannot be identified by culture techniques, genomic technology can be used for analysis of the composition of the microflora. PATIENTS AND METHODS: The mucosa associated colonic microflora of 57 patients with active inflammatory bowe...<br/><br/>S J Ott, M Musfeldt, D F Wenderoth, J Hampe, O Brant, U R Fölsch, K N Timmis, S Schreiber (2004) <i>Gut</i> <i></i> <i></i> 53: 5 685-693<br/>

http://publicationslist.org/s.ott/refid15 2009-10-16T12:05:30Z

The human gastrointestinal tract harbors an extremely diverse and complex microbial ecosystem. Most of the existent data about the enteric microflora have been generated using stool samples, but the collection and storage of fecal samples are often problematic. The influence of the storage of stool samples on the bacterial diversity and the degradation of bacterial DNA was analysed in this study. ...<br/><br/>Stephan J Ott, Meike Musfeldt, Kenneth N Timmis, Jochen Hampe, Dirk F Wenderoth, Stefan Schreiber (2004) <i>Diagn Microbiol Infect Dis</i> <i></i> <i></i> 50: 4 237-245<br/>

http://publicationslist.org/s.ott/refid16 2009-10-16T12:05:30Z

The composition of the human intestinal flora is important for the health status of the host. The global composition and the presence of specific pathogens are relevant to the effects of the flora. Therefore, accurate quantification of all major bacterial populations of the enteric flora is needed. A TaqMan real-time PCR-based method for the quantification of 20 dominant bacterial species and grou...<br/><br/>Stephan J Ott, Meike Musfeldt, Uwe Ullmann, Jochen Hampe, Stefan Schreiber (2004) <i>J Clin Microbiol</i> <i></i> <i></i> 42: 6 2566-2572<br/>

http://publicationslist.org/s.ott/refid19 2009-10-16T12:05:30Z

Adult Still's disease is a well-characterized rheumatic disorder of unknown origin, which may affect multiple organs and may have a fatal course. However, liver failure has rarely been described in adult Still's disease. We present the case of a 25-year-old woman who was admitted with acute liver failure 2 years after the start of symptoms (arthritis, fever, sore throat) of a yet undefined rheumat...<br/><br/>Stephan J Ott, Andreas Baron, Thomas Berghaus, Rolf Lamerz, Ulrich Beuers (2003) <i>Eur J Gastroenterol Hepatol</i> <i></i> <i></i> 15: 1 87-90<br/>

http://publicationslist.org/s.ott/refid30 2009-10-16T12:18:23Z

The production of abundant connective tissue within malignant tumors, the so-called desmoplastic stromal reaction, is a hallmark of colorectal adenocarcinomas. This stroma is produced to a large extent by myofibroblasts and contains various amounts of collagens (type I, III, and V), chondroitin sulfate proteoglycan, hyaluronic acid, fibronectin, and tenascin-C. In this study we have established a ...<br/><br/>Steffen Hauptmann, Antje Siegert, Stefan Berger, Carsten Denkert, Martin Köbel, Stefan Ott, Annalisa Siri, Laura Borsi (2003) <i>Eur J Cell Biol</i> 82: 1 1-8<br/>

http://publicationslist.org/s.ott/refid18 2009-10-16T12:05:30Z

Stephan J Ott, Thomas Helmberger, Ulrich Beuers (2003) <i>Am J Gastroenterol</i> <i></i> <i></i> 98: 2 512-513<br/>

http://publicationslist.org/s.ott/refid31 2009-10-16T12:19:41Z

R M Hoffmann, S Ott, K G Parhofer, R Bartl, G R Pape (1998) <i>J Hepatol</i> 29: 1 <br/>

http://publicationslist.org/s.ott/refid32 2009-10-16T12:20:14Z

In this study we compared the expression of integrin alpha chains 2, 3, 4, 5, 6, v and the beta chains 1, 3, 4 in 2 colorectal carcinoma cell lines (HRT-18 and CX-2), growing in confluent and subconfluent monolayer cultures, as multicellular tumor spheroids and in nude mice, using the immunofluorescence technique (confocal microscopy) and flow cytometry. The fast-growing cell line HRT-18 expressed...<br/><br/>S Hauptmann, C Denkert, H Löhrke, L Tietze, S Ott, B Klosterhalfen, C Mittermayer (1995) <i>Int J Cancer</i> 61: 6 819-825<br/>