Saadettin Sel's Publications List

Complications of dexamethasone implants: risk factors, prevention, and clinical management.

2021-01-03T17:33:45Z

To evaluate major complications after intravitreal injection of dexamethasone implants (Ozurdex) and their clinical management.

Nil Celik, Ramin Khoramnia, Gerd U Auffarth, Saadettin Sel, Christian S Mayer (2020) International journal of ophthalmology 13: 10 1612-1620

[Sudden loss of vision after cosmetic face treatment].

2019-12-07T19:29:41Z

F N Auerbach, R Khoramnia, G U Auffarth, J A Carmona Hernandez, T Tandogan, D Kaiser, S Hähnel, S Sel (2018) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 115: 7 598-602

Quantification of surfactant proteins in tears of patients suffering from dry eye disease compared to healthy subjects.

2019-12-07T19:29:41Z

To quantify and compare the amounts of surfactant proteins SP-A, SP-B, SP-C and SP-D in the tear fluid collected from patients with dry eye syndrome and from individuals with a healthy ocular surface.

Andreas Posa, Friedrich Paulsen, Richard Dietz, Fabian Garreis, Ralph Sander, Martin Schicht, Saadettin Sel, Michael Scholz, Christian M Hammer, Lars Bräuer (2018) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 216: 90-94

Repeatability and Agreement of Central Corneal Thickness and Keratometry Measurements between Four Different Devices.

2018-05-04T18:38:10Z

To estimate repeatability and comparability of central corneal thickness (CCT) and keratometry measurements obtained by four different devices in healthy eyes. Fifty-five healthy eyes from 55 volunteers were enrolled in this study. CCT (IOLMaster 700, Pentacam HR, and Cirrus HD-OCT) and keratometry readings (IOLMaster 700, Pentacam HR, and iDesign) were measured. For statistical analysis, the cor...

Laszlo Kiraly, Jana Stange, Kathleen S Kunert, Saadettin Sel (2017) Journal of ophthalmology 2017:

Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment.

2018-05-04T18:39:00Z

Laboratory analysis and optical quality assessment of explanted hydrophilic intraocular lenses (IOLs) with clinically significant opacification after posterior lamellar keratoplasty (DMEK and DSAEK).

Bert C Giers, Tamer Tandogan, Gerd U Auffarth, Chul Y Choi, Florian N Auerbach, Saadettin Sel, Christian Mayer, Ramin Khoramnia (2017) BMC ophthalmology 17: 1

Repeatability and agreement of Scheimpflug-based and swept-source optical biometry measurements.

2018-05-04T18:39:00Z

To evaluate the repeatability and comparability of biometry parameters between a Scheimpflug-based topography with axial length measurement (Pentacam AXL, Oculus, Wetzlar, Germany) and a swept-source optical biometry (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany).

Saadettin Sel, Jana Stange, Delia Kaiser, Laszlo Kiraly (2017) Contact lens & anterior eye : the journal of the British Contact Lens Association 40: 5 318-322

Accumulation of the advanced glycation end product carboxymethyl lysine in breast cancer is positively associated with estrogen receptor expression and unfavorable prognosis in estrogen receptor-negative cases.

2018-05-04T18:40:13Z

Advanced glycation end products (AGEs) accumulate as a result of high concentrations of reactive aldehydes, oxidative stress, and insufficient degradation of glycated proteins. AGEs are therefore accepted biomarkers for aging, diabetes, and several degenerative diseases. Due to the Warburg effect and increased oxidative stress, cancer cells frequently accumulate significant amounts of AGEs. As the...

Norbert Nass, Atanas Ignatov, Ludwig Andreas, Christine Weißenborn, Thomas Kalinski, Saadettin Sel (2017) Histochemistry and cell biology 147: 5 625-634

High neuronatin (NNAT) expression is associated with poor outcome in breast cancer.

2018-05-04T18:39:00Z

Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein a...

Norbert Nass, Sarah Walter, Dörthe Jechorek, Christine Weissenborn, Atanas Ignatov, Johannes Haybaeck, Saadettin Sel, Thomas Kalinski (2017) Virchows Archiv : an international journal of pathology 471: 1 23-30

The receptor for advanced glycation end products RAGE is involved in corneal healing.

2018-05-04T18:39:00Z

Impaired corneal healing is still a major cause of blindness. As RAGE (receptor for advanced glycation endproducts) is involved in inflammation and wound healing in other tissues, we here investigated its relevance for corneal wound healing. Corneal re-epithelialization after alkaline injury was analysed in an ex-vivo approach with cultured, enucleated eyes from mice either of the C57Bl/6 NChR gen...

Norbert Nass, Stefanie Trau, Friedrich Paulsen, Delia Kaiser, Thomas Kalinski, Saadettin Sel (2017) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 211: 13-20

[Sudden bilateral decreased vision in a 14-year-old boy].

2019-12-07T19:29:41Z

S Marx, A Scheuerle, R Khoramnia, T Tandogan, D Kaiser, G U Auffarth, S Sel (2017) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 114: 8 748-750

The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages.

2018-05-04T18:38:10Z

Monitoring cycling behaviours of stem and somatic cells in the living animal is a powerful tool to better understand tissue development and homeostasis. The tg(anillin:anillin-eGFP) transgenic line carries the full-length zebrafish F-actin binding protein Anillin fused to eGFP from a bacterial artificial chromosome (BAC) containing Anillin cis-regulatory sequences. Here we report the suitability o...

Meret Cepero Malo, Anne-Laure Duchemin, Luca Guglielmi, Eva Patzel, Saadettin Sel, Gerd U Auffarth, Matthias Carl, Lucia Poggi (2017) PloS one 12: 1

Temporal and spatial expression pattern of Nnat during mouse eye development.

2017-09-09T20:49:30Z

Neuronatin (Nnat) was initially identified as a highly expressed gene in neonatal mammalian brain. In this study, we analyze the spatial and temporal expression pattern of Nnat during mouse eye development as well as in the adult.

Saadettin Sel, Eva Patzel, Lucia Poggi, Delia Kaiser, Thomas Kalinski, Martin Schicht, Friedrich Paulsen, Norbert Nass (2017) Gene expression patterns : GEP 23-24: 7-12

1,25-dihydroxyvitamin D3 inhibits corneal wound healing in an ex-vivo mouse model.

2016-12-29T16:25:01Z

Impaired healing of corneal injuries can result in ulceration and complete loss of vision, especially in the elderly. Such patients frequently also exhibit vitamin D insufficiency. 1,25-dihydroxyvitamin D3 is the active vitamin D metabolite. As it affects cell proliferation and inflammation, we herein aimed at elucidating its influence on corneal wound healing after alkali burn by using in vitro a...

Saadettin Sel, Stefanie Trau, Friedrich Paulsen, Thomas Kalinski, Gabriele I Stangl, Norbert Nass (2016) Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 254: 4 717-724

CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.

2016-12-29T16:25:01Z

Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing. For a long time, a receptor for TFF3 had not yet been identified. However, the chemokine receptor CXCR4 has been described as a low affinity receptor for TFF2. Additionally, CXCR7, which is able to ...

Julia Dieckow, Wolfgang Brandt, Kirsten Hattermann, Stefan Schob, Ute Schulze, Rolf Mentlein, Philipp Ackermann, Saadettin Sel, Friedrich P Paulsen (2016) Investigative ophthalmology & visual science 57: 1 56-65

Somatostatin supports corneal wound healing in vivo.

2017-09-09T20:50:20Z

To evaluate the influence of somatostatin (SST) and its analog octreotid (Oct) on corneal wound healing processes.

Ulrike Hampel, Paul Frömmling, Lars Bräuer, Ivonne Schaefer, Saadettin Sel, Detlev Holland, Friedrich Paulsen (2016) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 205: 1-8

[Anatomy and physiology of the nasolacrimal ducts].

2017-09-09T20:50:20Z

Ophthalmologists and interventional radiologists are not the only professionals for whom diseases of the efferent tear duct system occupy centre stage; this applies also to ENT specialists involving endonasal conservative or surgical treatment. On the basis of current knowledge and taking account of results yielded by own research in recent years and of clinical aspects, we here give an overview o...

F Paulsen, F Garreis, M Schicht, L Bräuer, M J Ali, S Sel (2016) HNO 64: 6 354-366

Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative.

2017-09-09T20:50:20Z

Acquired tamoxifen resistance is a significant problem in estrogen receptor positive breast cancer. In a cellular model, tamoxifen resistance was associated with increased sensitivity towards toxic dicarbonyls and reduced free sulfhydryl group content. We here analyzed the role of oxidative stress and glyoxalase I activity on dicarbonyl resistance and the significance of glyoxalase I expression fo...

Norbert Nass, Saadettin Sel, Atanas Ignatov, Albert Roessner, Thomas Kalinski (2016) Biochimica et biophysica acta 1860: 6 1272-1280

[Bilateral crystalline deposits in corneal stroma].

2018-05-04T18:40:13Z

F N Auerbach, R Khoramnia, G U Auffarth, J A Carmona Hernandez, T Tandogan, S Sel (2016) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 113: 6 520-523

The distribution of human surfactant proteins within the oral cavity and their role during infectious diseases of the gingiva.

2016-12-29T16:25:01Z

The oral cavity with the teeth and the surrounding gingival epithelium, the periodontium, the salivary glands and other structures are open to the oral environment and thus exposed to multiple microbiological and pathogenic influences. To prevent permanent inflammatory processes such as gingivitis or periodontitis an efficient defense system is essential to ensure healthy and physiological functio...

Martin Schicht, Christina Stengl, Sadettin Sel, Friedhelm Heinemann, Werner Götz, Anselm Petschelt, Matthias Pelka, Michael Scholz, Felix Rausch, Friedrich Paulsen, Lars Bräuer (2015) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 199: 92-97

Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function.

2016-12-29T16:25:01Z

Divisions that generate one neuronal lineage-committed and one self-renewing cell maintain the balance of proliferation and differentiation for the generation of neuronal diversity. The asymmetric inheritance of apical domains and components of the cell division machinery has been implicated in this process, and might involve interactions with cell fate determinants in regulatory feedback loops of...

Alessio Paolini, Anne-Laure Duchemin, Shahad Albadri, Eva Patzel, Dorothee Bornhorst, Paula González Avalos, Steffen Lemke, Anja Machate, Michael Brand, Saadettin Sel, Vincenzo Di Donato, Filippo Del Bene, Flavio R Zolessi, Mirana Ramialison, Lucia Poggi (2015) Development (Cambridge, England) 142: 5 832-839

[Avulsion of the Globe after Bicycle Accident--Clinical and Histopathological Evaluation].

2016-12-29T16:25:01Z

Potential pathological mechanisms and complications of traumatic avulsio bulbi will be discussed based on the history, clinical, and histopathological findings of two patients.

I Schmack, M Schargus, S Hähnel, G Auffarth, S Sel (2015) Klinische Monatsblatter fur Augenheilkunde 232: 11 1308-1311

Biomechanical efficacy of collagen crosslinking in porcine cornea using a femtosecond laser pocket.

2016-12-29T16:26:20Z

The aim of this study was to assess the biomechanical efficacy of transepithelial collagen crosslinking using the femtosecond laser pocket technique compared with that using the standard crosslinking (CXL) technique.

Gregor Wollensak, Christian M Hammer, Eberhard Spörl, Jörg Klenke, Katrin Skerl, Yao Zhang, Saadettin Sel (2014) Cornea 33: 3 300-305

Special pattern of endochondral ossification in human laryngeal cartilages: X-ray and light-microscopic studies on thyroid cartilage.

2016-12-29T16:26:20Z

Endochondral ossification is a process that also occurs in the skeleton of the larynx. Differences in the ossification mechanism in comparison to growth plates are not understood until now. To get deeper insights into this process, human thyroid cartilage was investigated by the use of X-rays and a series of light-microscopic stainings. A statistical analysis of mineralization was done by scanning...

Horst Claassen, Martin Schicht, Saadettin Sel, Friedrich Paulsen (2014) Clinical anatomy (New York, N.Y.) 27: 3 423-430

Differential response to α-oxoaldehydes in tamoxifen resistant MCF-7 breast cancer cells.

2016-12-29T16:26:20Z

Tamoxifen is the standard adjuvant endocrine therapy for estrogen-receptor positive premenopausal breast cancer patients. However, tamoxifen resistance is frequently observed under therapy. A tamoxifen resistant cell line has been generated from the estrogen receptor positive mamma carcinoma cell line MCF-7 and was analyzed for putative differences in the aldehyde defence system and accumulation o...

Norbert Nass, Hans-Jürgen Brömme, Roland Hartig, Sevil Korkmaz, Saadettin Sel, Frank Hirche, Aoife Ward, Andreas Simm, Stefan Wiemann, Anne E Lykkesfeldt, Albert Roessner, Thomas Kalinski (2014) PloS one 9: 7

UVA irradiation of riboflavin generates oxygen-dependent hydroxyl radicals.

2016-12-29T16:26:20Z

The aim of this study was to verify the formation of hydroxyl radicals (·OH) after ultraviolet A (UVA) irradiation of riboflavin (RF) by spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), and electron spin resonance spectroscopy.

Saadettin Sel, Norbert Nass, Sandy Pötzsch, Stefanie Trau, Andreas Simm, Thomas Kalinski, Gernot Iw Duncker, Friedrich E Kruse, Gerd U Auffarth, Hans-Jürgen Brömme (2014) Redox report : communications in free radical research 19: 2 72-79

[In vitro and in vivo investigations of a modified textile keratoprosthesis. ACTO TexKPRO].

2015-06-22T23:59:03Z

Clinical application of a keratoprosthesis (KPRO) is still a challenging task. Recent developments reflect the concepts of nut and bolt, intrastromal implantation or an osteoodontokeratoprosthesis (OOKP). A new concept of a textile KPRO has been evaluated in a limited human study with considerable difficulties which after termination of the study and considerable improvements was restarted using a...

N Schrage, A K Cordes, J Storsberg, S Sel, H Röthgen, N Nass, E Berndt, S Jockenhövel, A Meßner, C Panfil (2014) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 111: 3 247-253

Distribution of Young's modulus in porcine corneas after riboflavin/UVA-induced collagen cross-linking as measured by atomic force microscopy.

2016-12-29T16:26:20Z

Riboflavin/UVA-induced corneal collagen cross-linking has become an effective clinical application to treat keratoconus and other ectatic disorders of the cornea. Its beneficial effects are attributed to a marked stiffening of the unphysiologically weak stroma. Previous studies located the stiffening effect predominantly within the anterior cornea. In this study, we present an atomic force microsc...

Jan Seifert, Christian M Hammer, Johannes Rheinlaender, Saadettin Sel, Michael Scholz, Friedrich Paulsen, Tilman E Schäffer (2014) PloS one 9: 1

Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.

2016-12-29T16:26:20Z

Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required...

Thomas Kalinski, Saadettin Sel, Heiko Hütten, Martin Röpke, Albert Roessner, Norbert Nass (2014) PloS one 9: 6

SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation.

2016-12-29T16:26:20Z

The lung constantly interacts with numerous pathogens. Thus, complex local immune defence mechanisms are essential to recognise and dispose of these intruders. This work describes the detection, characterisation and three-dimensional structure of a novel protein of the lung (surfactant-associated protein 3 (SFTA3/SP-H)) with putative immunological features. Bioinformatics, biochemical and immunolo...

Martin Schicht, Felix Rausch, Susetta Finotto, Martina Mathews, Anja Mattil, Melanie Schubert, Beate Koch, Maximilian Traxdorf, Christopher Bohr, Dieter Worlitzsch, Wolfgang Brandt, Fabian Garreis, Saadettin Sel, Friedrich Paulsen, Lars Bräuer (2014) The European respiratory journal 44: 2 447-456

Trefoil factor family peptide 3 (TFF3) is upregulated under experimental conditions similar to dry eye disease and supports corneal wound healing effects in vitro.

2016-12-29T16:26:20Z

To elucidate the role of trefoil family peptide (TFF) 3 at the ocular surface under conditions similar to dry eye disease (DED) and in tears of patients suffering from DED.

Ute Schulze, Ulrike Hampel, Saadettin Sel, Laura Contreras-Ruiz, Martin Schicht, Julia Dieckow, Yolanda Diebold, Friedrich Paulsen (2014) Investigative ophthalmology & visual science 55: 5 3037-3042

[Updated incidence of dry eye syndrome in Germany].

2016-12-29T16:26:20Z

Dry eye is one of the most common eye surface disorders. Patients suffer in particular from annoying subjective symptoms that compromise quality of life. The aim of the study was to find out when patients consult ophthalmologists in Germany and what symptoms they present.

A Posa, S Sel, R Dietz, R Sander, L Bräuer, F Paulsen (2014) Klinische Monatsblatter fur Augenheilkunde 231: 1 42-46

Insulin-like factor 3 promotes wound healing at the ocular surface.

2015-06-22T23:59:03Z

Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL3 and RXFP2 was determined in tissues of the ocular surface and lacrimal apparatu...

Ulrike Hampel, Thomas Klonisch, Saadettin Sel, Ute Schulze, Fabian Garreis, Holger Seitmann, Christos C Zouboulis, Friedrich P Paulsen (2013) Endocrinology 154: 6 2034-2045

Artifical cornea for ultima ratio patients

2013-04-17T13:53:58Z

Joachim Storsberg, Gernot I.W. Duncker, Christian Schmidt, Karin Kobuch, Arthur Messner, Saadettin Sel (2013) Zeitschrift für praktische Augenheilkunde und augenärztliche Fortbildung (ZPA) 34: 107-111

[Trauma of periorbital soft tissue. Reconstruction with regard to functional and aesthetic aspects].

2014-03-24T23:15:31Z

Complex midfacial trauma requires interdisciplinary management. A wide range of reconstructive procedures are needed and if necessary secondary and even tertiary interventions should be performed at the appropriate time. We present the case of a 45-year-old man who was involved in a car accident and presented with severe injuries to the periorbital soft tissue. The focus was on the reconstruction ...

W Reich, S Sel, L Holbach, F Paulsen, K Scheller (2013) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 110: 7 663-667

Detection of surfactant proteins A, B, C, and D in human nasal mucosa and their regulation in chronic rhinosinusitis with polyps.

2015-06-22T23:59:03Z

The nasal mucosa is characterized by a multirow high prismatic ciliated epithelium representing the first barrier of the immune defense system against microbial and other environmental pathogenic influences. A number of nonspecific defense mechanisms, including the presence of lactoferrin, peroxidases, proteases, interferons, and lysozymes in nasal secretions, act to counter inflammatory processes...

Martin Schicht, Stephan Knipping, Roman Hirt, Stephanie Beileke, Saadettin Sel, Friedrich Paulsen, Lars Bräuer (2013) American journal of rhinology & allergy 27: 1 24-29

Intraorbital oculomotor nerve schwannoma affecting only the parasympathetic fibers.

2014-03-24T23:15:31Z

C Scheller, J C Rachinger, J Prell, A Alfieri, S Rampp, S Sel, K Scheller, C Strauss (2013) Journal of neurological surgery. Part A, Central European neurosurgery 74: 2 120-123

Evaluation of central corneal thickness after cataract surgery, penetrating keratoplasty and long-term soft contact lens wear.

2015-06-22T23:59:03Z

The aim of this study was to compare central corneal thickness (CCT) between corneas of normal healthy eyes (cNHE), corneas of eyes that had undergone cataract surgery by clear corneal phacoemulsification with implantation of an intracapsular intraocular lens (cIOL), corneal grafts after penetrating keratoplasty (gPK) and corneas of long-term soft contact lens wearers (cCL).

Saadettin Sel, Stefanie Trau, Matthias Knak, Thomas Kalinski, Delia Kaiser, Friedrich E Kruse, Cord Huchzermeyer, Gernot I W Duncker, Friedrich Paulsen, Gerd U Auffarth, Norbert Nass (2013) Contact lens & anterior eye : the journal of the British Contact Lens Association 36: 5 238-242

Test anxiety among German medical students and its impact on lifestyle and substance abuse.

2015-06-22T23:59:03Z

Ozan Yüksel Tektaş, Friedrich Paulsen, Saadetin Sel (2013) Medical teacher 35: 11

Correction: The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS.

2014-03-24T23:15:31Z

[This corrects the article on p. e74412 in vol. 8.].

Stefan Schob, Martin Schicht, Saadettin Sel, Dankwart Stiller, Alexander S Kekulé, Friedrich Paulsen, Erik Maronde, Lars Bräuer (2013) PloS one 8: 11

The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS.

2016-12-29T16:26:20Z

Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system. The ability of surfactant protein A and surfactant protein D to bind various pathogens and facilitate their elimination has been described in a vast number of studies...

Stefan Schob, Martin Schicht, Saadettin Sel, Dankwart Stiller, Alexander S Kekulé, Alexander Kekulé, Friedrich Paulsen, Erik Maronde, Lars Bräuer (2013) PloS one 8: 9

Chemokine and cytokine levels in osteoarthritis and rheumatoid arthritis synovial fluid.

2015-06-22T23:59:03Z

To develop a method of the assay of chemokine and cytokine signaling in synovial fluid from patients suffering from osteoarthritis (OA) or rheumatoid arthritis (RA) and evaluate the effect of heterophilic antibodies on the reliability of the data. 21 synovial fluid samples from OA and 16 synovial fluid samples from RA patients were analyzed using a unique 2 step dot sandwich ELISA based micro-well...

Ulrike Hampel, Stefan Sesselmann, Pavel Iserovich, Saadettin Sel, Friedrich Paulsen, Robert Sack (2013) Journal of immunological methods 396: 1-2 134-139

Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome.

2015-06-22T23:59:03Z

The present study aims at determining whether enzymes of urea synthesis are expressed in the human lacrimal gland and in tissues of ocular surface (conjunctiva, cornea), to give evidence for the hypothesis that urea can be locally formed from ocular tissues and is important for the composition of the tear fluid.

Kristin Jäger, Heike Kielstein, Matthias Dunse, Norbert Nass, Friedrich Paulsen, Saadettin Sel (2013) Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 251: 8 1995-2002

The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina.

2015-06-22T23:59:03Z

The forkhead transcription factor Foxk1 is an important regulator of myogenic progenitor cells. Since our previous data from mouse retina revealed that Foxk1 is upregulated in Ptf1a-deficient mice we investigated the spatial and temporal expression of Foxk1 during development of mouse retina. Expression of Foxk1 was analyzed on both mRNA and protein level. To identify Foxk1 transcripts, retina and...

Saadettin Sel, Christoph Münzenberg, Norbert Nass, Thomas Kalinski, Maja Datan, Gerd U Auffarth, Marc Töteberg-Harms, Matthias Zenkel, Friedrich E Kruse, Friedrich Paulsen, Martin Schicht (2013) Gene expression patterns : GEP 13: 7 280-286

Fresh and cryopreserved amniotic membrane secrete the trefoil factor family peptide 3 that is well known to promote wound healing.

2014-03-24T23:15:31Z

Amniotic membrane (AM) is often used for the treatment of ocular surface ulcerations and other corneal defects. Trefoil factor family (TFF) peptide 3 is produced by conjunctival goblet cells, participates in tear film physiology and has also been shown to be involved in ocular surface restitution after corneal injury. In the present study, we questioned whether AM also might be a source of TFF3 an...

Ute Schulze, Ulrike Hampel, Saadettin Sel, Tamme W Goecke, Volker Thäle, Fabian Garreis, Friedrich Paulsen (2012) Histochemistry and cell biology 138: 2 243-250

Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels.

2014-03-24T23:15:31Z

The Rho GTPase activating protein (RhoGAP) Oligophrenin 1 (Ophn1) regulates numerous members of the Rho family that are involved in neuronal morphogenesis of the central and peripheral nervous system. In the present study we investigated the spatial and temporal expression of Ophn1 in the mouse eye. The expression of Ophn1 was analysed on both mRNA and protein level. To identify the Ophn1 transcri...

Saadettin Sel, Maja Kaiser, Norbert Nass, Stefanie Trau, Albrecht Roepke, Joachim Storsberg, Ulrike Hampel, Friedrich Paulsen, Thomas Kalinski (2012) Gene expression patterns : GEP 12: 1-2 63-67

RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet.

2014-03-24T23:15:31Z

The metabolic syndrome is defined by the presence of obesity, insulin resistance, dyslipidemia, and hypertension. Advanced glycation end products (AGEs) are stable end products of the Maillard reaction, whereby AGE accumulation is considered not only a biomarker of aging but is also associated with several degenerative diseases. AGEs are recognized by several receptor molecules of which the recept...

B Leuner, M Max, K Thamm, C Kausler, Y Yakobus, A Bierhaus, S Sel, B Hofmann, R-E Silber, A Simm, N Nass (2012) Zeitschrift für Gerontologie und Geriatrie 45: 2 102-108

Bone marrow cells and CD117-positive haematopoietic stem cells promote corneal wound healing.

2014-03-24T23:15:31Z

The present study was conducted to evaluate the therapeutic effects of topically applied bone marrow (BM) cells and CD117-positive haematopoietic stem (CD117(+)) cells on alkali-induced corneal ulcers.

Saadettin Sel, Ulf M Schilling, Norbert Nass, Andreas Simm, Fabian Garreis, Matthias Knak, Joachim Storsberg, Maja Kaiser, Thomas Kalinski, Dirk Ehrich, Timm Bredehorn-Mayr, Friedrich Paulsen (2012) Acta ophthalmologica 90: 5 e367-e373

Relaxin 2 is functional at the ocular surface and promotes corneal wound healing.

2014-03-24T23:15:31Z

We aimed to determine if the insulin-like peptide hormone relaxin 2 (RLN2) is expressed at the ocular surface and in tears and if RLN2 influences wound healing at the ocular surface, which is associated with extracellular matrix (ECM) remodeling.

Ulrike Hampel, Thomas Klonisch, Saadettin Sel, Ute Schulze, Fabian Garreis, Friedrich P Paulsen (2012) Investigative ophthalmology & visual science 53: 12 7780-7790

Expression analysis of ADAM17 during mouse eye development.

2014-03-24T23:15:31Z

ADAM17 (a disintegrin and metallopeptidase domain 17) is crucial for eye morphogenesis. In this study we analysed the expression pattern of ADAM17 during mouse eye development. ADAM17 expression in adult retina was examined using the reverse transcription-polymerase chain reaction (RT-PCR) and verification of the RT-PCR products by DNA sequencing. Immunohistochemistry was performed to evaluate the...

Saadettin Sel, Thomas Kalinski, Isabelle Enssen, Maja Kaiser, Norbert Nass, Stefanie Trau, Gregor Wollensak, Lars Bräuer, Kristin Jäger, Friedrich Paulsen (2012) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 194: 4 334-338

A novel ELISA-based crossmatch procedure to detect donor-specific anti-HLA antibodies responsible for corneal allograft rejections.

2014-03-24T23:15:31Z

Previous studies had shown that donor-specific anti-HLA antibodies may highly influence the survival rate of corneal allografts, although the anterior chamber generally represents an immune-privileged compartment of the eye. We postulated that the introduction of a novel crossmatch procedure for the detection of donor-specific anti-HLA antibodies in recipients awaiting a corneal graft would be ade...

Saadettin Sel, Gerald Schlaf, Oliver Schurat, Wolfgang W Altermann (2012) Journal of immunological methods 381: 1-2 23-31

Metabolic profile of porcine corneas after photodynamic cross-linking treatment.

2014-03-24T23:15:31Z

Tomasz Kryczka, Saadettin Sel, Gregor Wollensak, Anna Midelfart (2012) Acta ophthalmologica 90: 8 e658-e659

RAGE-dependent activation of gene expression of superoxide dismutase and vanins by AGE-rich extracts in mice cardiac tissue and murine cardiac fibroblasts.

2014-03-24T23:15:31Z

Advanced glycation end products (AGEs) are stable compounds formed from initial Maillard reaction products. They are considered as markers for ageing and often associated with age-related, degenerative diseases. Bread crust represents an established model for nutritional compounds rich in AGEs and is able to induce antioxidative defense genes such as superoxide dismutases and vanins in cardiac cel...

Beatrice Leuner, Stefanie Ruhs, Hans-Jürgen Brömme, Angelika Bierhaus, Saadettin Sel, Rolf-Edgar Silber, Veronika Somoza, Andreas Simm, Norbert Nass (2012) Food & function 3: 10 1091-1098

Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light.

2014-03-24T23:15:31Z

Collagen crosslinking treatment of progressive keratoconus using the photosensitiser riboflavin and ultraviolet A light of 370 nm wavelength has been shown to increase significantly the tensile strength of corneal collagen by about 300%. In keratoconus, interlamellar and interfibrillar slippage have been proposed as pathogenetic mechanisms. Therefore, the aim of this study was to assess the impact...

G Wollensak, E Spörl, C Mazzotta, T Kalinski, S Sel (2011) The British journal of ophthalmology 95: 6 876-880

[Unilateral papilledema with contralateral loss of vision].

2014-03-24T23:15:31Z

A 46-year-old woman presented with a 4-day history of headache, dizziness and blurred vision in the left eye and a 1-year history of neck pain. Fundoscopy revealed a pale optic disc in the left eye and a swollen optic disc in the right eye. Furthermore a bilateral anosmia was evident. Cranial magnetic resonance imaging (MRI) showed a mass in the anterior cranial fossa, which was classified as a WH...

C Münzenberg, F Paulsen, T Kalinski, M Kaiser, N Nass, G I W Duncker, S Sel (2011) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 108: 2 170-173

Retinal astrocytomas: long-term follow-up.

2014-03-24T23:15:31Z

Retinal astrocytomas are exceedingly rare benign tumours of the retina. Their occurrence can be solitary or multiple, uni- or bilateral, isolated or in association with a phakomatosis such as tuberous sclerosis or neurofibromatosis type 1.

M Töteberg-Harms, V Sturm, S Sel, A Sasse, K Landau (2011) Klinische Monatsblätter für Augenheilkunde 228: 4 337-339

Impact of clinical factors on the long-term functional and anatomic outcomes of osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis.

2014-03-24T23:15:31Z

To report the long-term functional and anatomic outcomes of osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis; to analyze the influence of clinical factors, such as surgical technique, primary diagnosis, age, and postoperative complications, on the final outcome.

María Fideliz De La Paz, Juan Álvarez De Toledo, Victor Charoenrook, Saadettin Sel, José Temprano, Rafael I Barraquer, Ralph Michael (2011) American journal of ophthalmology 151: 5 829-839.e1

In vitro evidence of involvement of the epithelial y+ transporter in β-defensin production on the ocular surface.

2014-03-24T23:15:31Z

To analyse the hypothesis as to whether there is a functional relationship between human cationic amino acid transporters (hCATs, y(+) transporter, the main transporter of L-arginine and L-lysine) and human β-defensin (important components of immune function) production on the ocular surface, arginase and nitrate monoxide synthase (NOS), enzymes that compete for L-arginine, were inhibited by norN...

Kristin Jäger, Andrea Nielitz, Fabian Garreis, Saadettin Sel, Heike Nave, Friedrich P Paulsen (2011) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 193: 6 479-485

Expression analysis of ADAM17 during mouse eye development.

2011-11-12T21:35:16Z

Limbal and conjunctival epithelium after corneal cross-linking using riboflavin and UVA.

2014-03-24T23:15:31Z

To assess possible cellular damage in the corneal and conjunctival epithelium after corneal cross-linking treatment.

Gregor Wollensak, Cosimo Mazzotta, Thomas Kalinski, Saadettin Sel (2011) Cornea 30: 12 1448-1454

Lossless compression of JPEG2000 whole slide images is not required for diagnostic virtual microscopy.

2014-03-24T23:15:31Z

The use of lossy compression in medical imaging is controversial, although it is inevitable to reduce large data amounts. In contrast with lossy compression, lossless compression does not impair image quality. In addition to our previous studies, we evaluated virtual 3-dimensional microscopy using JPEG2000 whole slide images of gastric biopsy specimens with or without Helicobacter pylori gastritis...

Thomas Kalinski, Ralf Zwönitzer, Florian Grabellus, Sien-Yi Sheu, Saadettin Sel, Harald Hofmann, Albert Roessner (2011) American journal of clinical pathology 136: 6 889-895

Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes.

2014-03-24T23:15:31Z

Trefoil factor 3 (TFF3, also known as intestinal trefoil factor) is a member of a family of protease-resistant peptides containing a highly conserved motif with 6 cysteine residues. Recent studies have shown that TFF3 is expressed in injured cornea, where it plays a role in corneal wound healing, but not in healthy cornea. Since cartilage and cornea have similar matrix properties, we undertook the...

Sophie Rösler, Tobias Haase, Horst Claassen, Ute Schulze, Martin Schicht, Dagmar Riemann, Jörg Brandt, David Wohlrab, Brigitte Müller-Hilke, Mary B Goldring, Saadettin Sel, Deike Varoga, Fabian Garreis, Friedrich P Paulsen (2010) Arthritis and rheumatism 62: 3 815-825

Significance of the riboflavin film in corneal collagen crosslinking.

2014-03-24T23:15:31Z

To evaluate the role of the preocular riboflavin film in ultraviolet-A (UVA) absorption in corneal collagen crosslinking (CXL).

Gregor Wollensak, Henning Aurich, Christopher Wirbelauer, Saadettin Sel (2010) Journal of cataract and refractive surgery 36: 1 114-120

Trefoil factor family peptide 3 at the ocular surface. A promising therapeutic candidate for patients with dry eye syndrome?

2014-03-24T23:15:31Z

Dry eye syndrome is a widespread disease accompanied by discomfort and potential visual impairments. Basic causes are tear film instability, hyperosmolarity of the tear film, increased apoptosis as well as chronic inflammatory processes. During the last decades, our understanding of dry eye syndrome has considerably increased. However, the molecular mechanisms of the disease remain largely elusive...

U Schulze, S Sel, F P Paulsen (2010) Developments in ophthalmology 45: 1-11

Expression profile of aquaporins in human nasolacrimal duct epithelium.

2014-03-24T23:15:31Z

To determine whether the epithelium of the human nasolacrimal ducts contains aquaporins (AQPs), a family of membrane proteins that function as selective pores and are able to transport water, glycerol, and other small solutes across the cell plasma membrane.

Kristin Jäger, Dorothea Reh, Matthias Gebhardt, Ulrich Schaudig, Saadettin Sel, Lars Bräuer, Friedrich Paulsen (2010) Current eye research 35: 4 267-273

The fate of chondrocytes during ageing of human thyroid cartilage.

2014-03-24T23:15:31Z

Human laryngeal cartilages, especially thyroid cartilage, exhibit gender-specific ageing. In contrast to male thyroid cartilages, the ventral half of the female thyroid cartilage plate remains unmineralized until advanced age. In cartilage specimens from laryngectomies and autopsies, apoptosis was studied immunohistochemically and the oxidative mitochondrial enzyme nicotinamide adenine dinucleotid...

Horst Claassen, Martin Schicht, Saadettin Sel, Jochen Werner, Friedrich Paulsen (2009) Histochemistry and cell biology 131: 5 605-614

Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes.

2014-03-24T23:15:31Z

Recent investigations support the presence of human somatostatin (SS) in the excretory system of the human lacrimal gland. To get deeper insights into a possible role of SS at the ocular surface and in the lacrimal apparatus, we investigated the distribution pattern of SS and its receptors 1-5 (SSTR1-5) by means of RT-PCR, real-time RT-PCR, Western blot and immunodot blot analysis as well as immun...

Ivonne Minsel, Rolf Mentlein, Saadettin Sel, Yolanda Diebold, Lars Bräuer, Eckhard Mühlbauer, Friedrich P Paulsen (2009) Endocrinology 150: 5 2254-2263

Lossy compression in diagnostic virtual 3-dimensional microscopy--where is the limit?

2014-03-24T23:15:31Z

Data compression is inevitable to reduce the huge data amounts of virtual slides, especially in virtual 3-dimensional (3D) microscopy. Lossy compression influences the image quality and leads to recognizable compression artifacts above a compression ratio of 20:1 in JPEG2000 format. To test out whether higher compression ratios are acceptable in diagnostic pathology, we prepared virtual 3D slides ...

Thomas Kalinski, Ralf Zwönitzer, Florian Grabellus, Sien-Yi Sheu, Saadettin Sel, Harald Hofmann, Johannes Bernarding, Albert Roessner (2009) Human pathology 40: 7 998-1005

Heterogeneity of angiogenesis and blood vessel maturation in cartilage tumors.

2014-03-24T23:15:31Z

Cartilage tumors have a special angiogenic phenotype, with blood vessels arranged predominantly in pericartilage fibrous septa and relatively low microvessel density (MVD), except in dedifferentiated chondrosarcomas. To further elucidate angiogenesis in cartilage tumors, we used double-labeling immunohistochemistry to determine microvessel pericyte coverage index (MPI) and proliferating capillary ...

Thomas Kalinski, Saadettin Sel, Irina Kouznetsova, Martin Röpke, Albert Roessner (2009) Pathology, research and practice 205: 5 339-345

Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma.

2014-03-24T23:15:31Z

As ephrins have been associated with tumorigenesis and tumor progression, we investigated ephrin-A5 (EFNA5) expression in specimens of normal cartilage and chondrosarcomas of different grade by conventional and quantitative reverse transcription polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry. We detected a significant EFNA5 down-regulation in chondrosarcomas compared wi...

Thomas Kalinski, Albrecht Röpke, Saadettin Sel, Irina Kouznetsova, Martin Röpke, Albert Roessner (2009) Human pathology 40: 12 1679-1685

[Unusual myopic fundus alteration].

2014-03-24T23:15:31Z

A 44-year-old female patient reported a "black dot" which had been in front of the right eye for more than 4 days and which moved together with eye movements. The optical coherence tomography (OCT) image of the right macula showed large cystic cavities and thickening within the retinal pigment epithelium (RPE) near the fovea centralis as well as small bore cystic alterations, which indicated an ev...

C Münzenberg, F Paulsen, T Kalinski, A Dmitriew, G I W Duncker, S Sel (2009) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 106: 7 628-631

WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes.

2014-03-24T23:15:31Z

Odonto-onycho-dermal dysplasia (OODD), a rare autosomal-recessive inherited form of ectodermal dysplasia including severe oligodontia, nail dystrophy, palmoplantar hyperkeratosis, and hyperhidrosis, was recently shown to be caused by a homozygous nonsense WNT10A mutation in three consanguineous Lebanese families. Here, we report on 12 patients, from 11 unrelated families, with ectodermal dysplasia...

Axel Bohring, Thomas Stamm, Christiane Spaich, Claudia Haase, Kerstin Spree, Ute Hehr, Mandy Hoffmann, Susanne Ledig, Saadettin Sel, Peter Wieacker, Albrecht Röpke (2009) American journal of human genetics 85: 1 97-105

[Clinical course of a solitary retinal astrocytoma].

2014-03-24T23:15:31Z

Retinal astrocytomas are benign tumors of the retina. Their localization can be solitary, multiple, or bilateral in both eyes. It is also known that they can be part of a phakomatosis syndrome (i.e., tuberous sclerosis or neurofibromatosis). Because retinal astrocytomas have a slow growth rate, yearly controls by an ophthalmologist with interdisciplinary consultation are adequate. Some uncommon ca...

M Töteberg-Harms, F Paulsen, G I W Duncker, S Sel (2009) Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 106: 10 921-923

Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds.

2014-03-24T23:15:31Z

Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem. These conditions affect many tissues, are painful, and are difficult to treat. In this study using cornea as a model, we demonstrate the importance of trefoil factor 3 (TFF3, also known as intestinal trefoil factor) in re-epithelialization of wounds. In two different models of cornea...

Friedrich P Paulsen, Chee-Wai Woon, Deike Varoga, Anne Jansen, Fabian Garreis, Kristin Jäger, Marita Amm, Daniel K Podolsky, Philipp Steven, Nicholas P Barker, Saadettin Sel (2008) The Journal of biological chemistry 283: 19 13418-13427

Digital workflow management for quality assessment in pathology.

2014-03-24T23:15:31Z

Information systems (IS) are well established in the multitude of departments and practices of pathology. Apart from being a collection of doctor's reports, IS can be used to organize and evaluate workflow processes. We report on such a digital workflow management using IS at the Department of Pathology, University Hospital Magdeburg, Germany, and present an evaluation of workflow data collected o...

Thomas Kalinski, Saadettin Sel, Harald Hofmann, Ralf Zwönitzer, Johannes Bernarding, Albert Roessner (2008) Pathology, research and practice 204: 1 17-21

Regulation of MUC16 by inflammatory mediators in ocular surface epithelial cell lines.

2014-03-24T23:15:31Z

The aim of the present study was to evaluate the regulation of membrane-anchored mucin MUC16 by proinflammatory cytokines and bacterial components at the ocular surface. Expression and distribution of MUC16 in conjunctival (HCjE) and corneal (HCE) epithelial cell lines was monitored by RT-PCR and immunohistochemistry. To determine the regulation of MUC16, cultured HCjEs and HCEs were stimulated wi...

Friedrich Paulsen, Kristin Jäger, Dieter Worlitzsch, Lars Bräuer, Ute Schulze, Gesa Schäfer, Saadettin Sel (2008) Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 190: 1 59-70

Virtual 3D microscopy using multiplane whole slide images in diagnostic pathology.

2014-03-24T23:15:31Z

To reproduce focusing in virtual microscopy, it is necessary to construct 3-dimensional (3D) virtual slides composed of whole slide images with different focuses. As focusing is frequently used for the assessment of Helicobacter pylori colonization in diagnostic pathology, we prepared virtual 3D slides with up to 9 focus planes from 144 gastric biopsy specimens with or without H pylori gastritis. ...

Thomas Kalinski, Ralf Zwönitzer, Saadettin Sel, Matthias Evert, Thomas Guenther, Harald Hofmann, Johannes Bernarding, Albert Roessner (2008) American journal of clinical pathology 130: 2 259-264

Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system.

2014-03-24T23:15:31Z

To evaluate the expression and presence of surfactant protein (SP) A and SP-D in the lacrimal apparatus, at the ocular surface, and in tears in healthy and pathologic states.

Lars Bräuer, Christian Kindler, Kristin Jäger, Saadettin Sel, Bernhard Nölle, Uwe Pleyer, Matthias Ochs, Friedrich P Paulsen (2007) Investigative ophthalmology & visual science 48: 9 3945-3953

ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma.

2014-03-24T23:15:31Z

Angiogenesis is characteristic of cartilage tumors, not of normal cartilage tissue. In addition to our previous report on differential expression of proangiogenic vascular endothelial growth factor A (VEGF-A) in cartilage tumors, we analyzed the expression of a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), which has been identified as a potent inhibitor of VEGF-A. We fu...

Thomas Kalinski, Sabine Krueger, Saadettin Sel, Kerstin Werner, Martin Röpke, Albert Roessner (2007) Human pathology 38: 1 86-94

MUC16 in the lacrimal apparatus.

2014-03-24T23:15:31Z

The aim of the present study was to determine the possible expression of the mucin MUC16 in the lacrimal apparatus. Expression and distribution of MUC16 in lacrimal gland, accessory lacrimal glands, and nasolacrimal ducts was monitored by RT-PCR and immunohistochemistry. MUC16 was expressed and detected in all tissues investigated. Comparable to conjunctiva and cornea it was membrane-anchored in a...

Kristin Jäger, Guangxi Wu, Saadettin Sel, Fabian Garreis, Lars Bräuer, Friedrich P Paulsen (2007) Histochemistry and cell biology 127: 4 433-438

Distribution of sex chromosomes in dysgenetic gonads of mixed type.

2014-03-24T23:15:31Z

In a four-week-old child with female external and internal genitalia but with clitoris hypertrophy chromosome analysis from blood lymphocytes revealed a 46,XY karyotype. No deletion of Y chromosomal sequences was detected by PCR analysis of genomic DNA isolated from peripheral blood leucocytes. Because of the increased risk for gonadal tumours, gonadectomy was performed. Conventional cytogenetic a...

A Röpke, T Kalinski, K Mohnike, S Sel, S Jakubiczka, A-F Pelz, A Roessner, P F Wieacker (2007) Cytogenetic and genome research 116: 1-2 146-151

Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina.

2014-03-24T23:15:31Z

Basic helix-loop-helix (bHLH) transcription factors are important regulators of retinal neurogenesis. In the developing retina, proneural bHLH genes have highly defined expressions, which are influenced by pattern formation and cell-specification pathways. We report here that the tissue-specific bHLH transcription factor Ptf1a (also known as PTF1-p48) is expressed from embryonic day 12.5 of gestat...

Hassan Nakhai, Saadettin Sel, Jack Favor, Lidia Mendoza-Torres, Friedrich Paulsen, Gernot I W Duncker, Roland M Schmid (2007) Development (Cambridge, England) 134: 6 1151-1160

TFF peptides and mucins are major components of dacryoliths.

2014-03-24T23:15:31Z

The study was performed to determine whether trefoil factor peptides (TFF) and/or mucins are components of dacryoliths and to gain further insight into dacryolith composition and formation.

Friedrich P Paulsen, Ulrich Schaudig, Alexander Fabian, Dirk Ehrich, Saadettin Sel (2006) Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 244: 9 1160-1170

Comparison of the established standard complement-dependent cytotoxicity and flow cytometric crossmatch assays with a novel ELISA-based HLA crossmatch procedure.

2014-03-24T23:15:31Z

The detection of donor-specific anti-HLA antibodies by standard procedures such as complement-dependent cytotoxicity assay (CDC) or flow cytometric (FACS) analysis is limited by its low sensitivity and the quality of the donor cells. Therefore, an ELISA-based technique was employed using solid phase-immobilized monoclonal antibodies to capture HLA class I or class II molecules of the donor, respec...

W W Altermann, B Seliger, S Sel, D Wendt, G Schlaf (2006) Histology and histopathology 21: 10 1115-1124

Differential expression of VEGF-A and angiopoietins in cartilage tumors and regulation by interleukin-1beta.

2014-03-24T23:15:31Z

Vascular endothelial growth factor (VEGF)-A and angiopoietin (Ang)-1 and Ang-2 are key factors in angiogenic signaling. In this study the expression of these factors was identified in cartilage tumors. As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling, we further analyzed the effect of IL-1beta on the expression of VEGF-A, Ang-1, and Ang-2 using a previ...

Thomas Kalinski, Sabine Krueger, Saadettin Sel, Kerstin Werner, Martin Ropke, Albert Roessner (2006) Cancer 106: 9 2028-2038

Androgen receptors and gender-specific distribution of alkaline phosphatase in human thyroid cartilage.

2014-03-24T23:15:31Z

The degree of mineralization in human thyroid cartilage is gender specific. Until now, laryngeal tissue was tested for sexual hormone receptors by the use of radiolabelled hormones only without exact localization of the receptors. In this study immediately frozen cartilage specimens from seven male and one female patient who underwent laryngectomy were used for immunolocalization of sexual hormone...

Horst Claassen, Heiner Mönig, Saadettin Sel, Jochen A Werner, Friedrich Paulsen (2006) Histochemistry and cell biology 126: 3 381-388

Rosai-Dorfman disease with bilateral serous retinal detachment.

2014-03-24T23:15:31Z

Carsten H Meyer, Saadettin Sel, Steffen Hörle, Jürgen Burg, Peter Kroll (2003) Archives of ophthalmology 121: 5 733-735

HLA-B4431: a new HLA-B variant with a complex ancestral history involving HLA-B44, B40 and B07 alleles.

2014-03-24T23:15:31Z

We here describe the identification of the new allele HLA-B*4431, which was found in three members of a Turkish family. Sequencing of the new allele following haplotype-specific PCR amplification revealed that exon 2 is identical to HLA-B*4402, whereas exon 3 resembles a HLA-B*40 variant with the exception of position 572, where a single nucleotide transversion (C > G) leads to an amino acid excha...

M Przemeck, H-A Elsner, S Sel, L T Pastucha, R Blasczyk (2002) Tissue antigens 60: 1 91-94

Tumor cell-based vaccination in renal cell carcinoma: rationale. approaches, and recent clinical development.

2014-03-24T23:15:31Z

Since there is some evidence for spontaneous immunity against renal cell carcinoma, vaccination strategies are often used in patients with this tumor type, both in the adjuvant and the metastatic setting. Therefore, therapeutic strategies aim at augmenting anti-tumor immunity, but tumor-specific antigens suitable for vaccination purposes in renal cell carcinoma still remain to be identified. Early...

Johannes Volk, Saadettin Sel, Arnold Ganser, Patrick Schöffski (2002) Current drug targets 3: 5 401-408

Equivalent mobilization and collection of granulocytes for transfusion after administration of glycosylated G-CSF (3 microg/kg) plus dexamethasone versus glycosylated G-CSF (12 microg/kg) alone.

2014-03-24T23:15:31Z

The aim of this study was to find a regimen for mobilization and collection of granulocytes that combines low-dose G-CSF administration with satisfactory PMN mobilization and apheresis at a low rate of donor adverse reactions.

H G Heuft, L Goudeva, S Sel, R Blasczyk (2002) Transfusion 42: 7 928-934

The adjunctive value of routine biochemistry in nutritional assessment of hospitalized patients.

2014-03-24T23:15:31Z

Nutritional screening and assessment of patients are not part of the routine procedures at hospital admission, although a large percentage of patients is malnourished. Similarly, nutritional status of patients and dietary intake is usually not monitored during hospitalization. In contrast a great number of laboratory investigations for screening purposes accompanies most, if not all, hospital admi...

O Selberg, S Sel (2001) Clinical nutrition (Edinburgh, Scotland) 20: 6 477-485

Tumour microdissemination and survival in metastatic melanoma.

2014-03-24T23:15:31Z

The value of tyrosinase messenger RNA (mRNA) detection by reverse-transcriptase polymerase chain reaction (RT-PCR) as a marker for circulating melanoma cells remains controversial. However, it has been suggested that detection of melanoma cell mRNA may be used to evaluate prognosis and disease progression in patients with advanced malignant melanoma. We used a highly sensitive tyrosinase RT-PCR de...

A J Schrader, M Probst-Kepper, J Grosse, U Kunter, A Franzke, S Sel, E Atzpodien, J Buer (2000) Anticancer research 20: 5B 3619-3624

Interleukin 10 (IL-10): an immunosuppressive factor and independent predictor in patients with metastatic renal cell carcinoma.

2014-03-24T23:15:31Z

Interleukin 10 (IL-10) is an immunosuppressive factor and has been detected in tumour cell cultures of renal cell carcinoma and of malignant melanoma. IL-10 has been described as a cytokine of the Th2 response; it is able to suppress antigen-presenting cells (APCs) and may lead to down-regulation of HLA class I and II molecules on dendritic cells and to anergy of T-lymphocytes. We evaluated pretre...

F Wittke, R Hoffmann, J Buer, I Dallmann, K Oevermann, S Sel, T Wandert, A Ganser, J Atzpodien (1999) British journal of cancer 79: 7-8 1182-1184

[Chemoimmunotherapy in the systemic treatment of advanced renal carcinoma].

2014-03-24T23:15:31Z

Polychemotherapy and immunomodulating treatment using IL-2 and/or IFN-alpha produce objective responses in a proportion of advanced renal cell carcinoma patients. The goals of an improved cost effectiveness and therapeutic index of interleukin-2 and/or Interferon-alpha in combination with chemotherapeutic agents require the design of risk factor adapted individual therapeutic strategies for the ou...

J Atzpodien, J Buer, S Sel, J Janssen, K Oevermann (1999) Der Urologe. Ausg. A 38: 5 474-478

Prognostic impact of in vivo soluble cell adhesion molecules in metastatic renal cell carcinoma.

2014-03-24T23:15:31Z

The purpose of the study was to determine prognostic significance of pretreatment serum levels of different molecules involved in cell to cell interactions along with other clinical parameters in patients with metastatic renal cell carcinoma. sICAM-1, sVCAM-1 and sELAM-1 serum levels were determined by ELISA assays in sera from 99 patients with histologically confirmed progressive metastatic renal...

R Hoffmann, A Franzke, J Buer, S Sel, K Oevermann, A Duensing, M Probst, S Duensing, H Kirchner, A Ganser, J Atzpodien (1999) British journal of cancer 79: 11-12 1742-1745

Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4 alpha and HNF1 alpha.

2014-03-24T23:15:31Z

Human renal cell carcinogenesis is usually accompanied by dedifferentiation processes including the loss of expression of tissue specifically expressed genes. Based on the hypothesis that these dedifferentiation processes might be attributed to a functional change in tissue specific transcription factors, we have analyzed the expression and function of the tissue specific transcription factor HNF4...

S Sel, T Ebert, G U Ryffel, T Drewes (1996) Cancer letters 101: 2 205-210