http://publicationslist.org/data/simone.tomasi/atom.xml Simone Tomasihttp://publicationslist.org/simone.tomasi$basepathfavicon.icoRecent additions to Simone Tomasi's PublicationsList.org pagehttp://publicationslist.org/publications.png2018-09-10T23:15:29Z http://publicationslist.org/simone.tomasi/refid13 2018-09-10T23:15:19Z

The GABAergic system is regulated by the brain-derived neurotrophic factor (BDNF)/Tropomyosin-related kinase B (TrkB) pathway, but the cell-intrinsic role of TrkB signaling in parvalbumin cortical interneuron development and function is unclear. We performed conditional ablation of the TrkB receptor in parvalbumin-expressing (PV) interneurons to study whether postnatal loss of TrkB in parvalbumin ...<br/><br/>Dionysios Xenos, Marija Kamceva, Simone Tomasi, Jessica A Cardin, Michael L Schwartz, Flora M Vaccarino (2017) <i>Cerebral cortex (New York, N.Y. : 1991)</i> <i></i> <i></i> : 1-15<br/>

http://publicationslist.org/simone.tomasi/refid14 2018-09-10T23:15:19Z

One major aim in quantitative and translational neuroscience is to achieve a precise and fast neuronal counting method to work on high throughput scale to obtain reliable results. Here, we tested the isotropic fractionator (IF) method for evaluating neuronal and non-neuronal cell loss in different models of central nervous system (CNS) pathologies. Sprague-Dawley rats underwent: (i) ischemic brain...<br/><br/>Ivan E Repetto, Riccardo Monti, Marta Tropiano, Simone Tomasi, Alessia Arbini, Carlos-Humberto Andrade-Moraes, Roberto Lent, Alessandro Vercelli (2016) <i>Frontiers in cellular neuroscience</i> <i></i> <i></i> 10: <br/>

http://publicationslist.org/simone.tomasi/refid15 2018-09-10T23:15:19Z

Despite strong evidence linking fibroblast growth factor 2 (FGF2) with anxiety and depression in both rodents and humans, the molecular mechanisms linking FGF2 with anxiety are not understood.<br/><br/>Natalina Salmaso, Hanna E Stevens, Jessica McNeill, Maha ElSayed, Qiuyin Ren, Maria E Maragnoli, Michael L Schwartz, Simone Tomasi, Robert M Sapolsky, Ronald Duman, Flora M Vaccarino (2016) <i>Biological psychiatry</i> <i></i> <i></i> 80: 6 479-489<br/>

http://publicationslist.org/simone.tomasi/refid16 2018-09-10T23:15:19Z

Claudia Queiroga, Ana Almeida, Simone Tomasi, Alessandro Vercelli, Paula Paula, Helena Vieira (2015) <i>SpringerPlus</i> <i></i> <i></i> 4: Suppl 1 <br/>

http://publicationslist.org/simone.tomasi/refid11 2018-09-10T23:15:19Z

Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads to neuronal death. c-Jun-N-terminal kinase (JNK) has a key role in excitotoxic cell death. We have previously shown that JNK inhibition by a specific cell-permeable peptide significantly reduces infarct size and neuronal death in an in vivo model of cerebral ischemia. However, systemic inhibition of JNK may have de...<br/><br/>A Vercelli, S Biggi, A Sclip, I E Repetto, S Cimini, F Falleroni, S Tomasi, R Monti, N Tonna, F Morelli, V Grande, M Stravalaci, E Biasini, O Marin, F Bianco, D di Marino, T Borsello (2015) <i>Cell death & disease</i> <i></i> <i></i> 6: <br/>

http://publicationslist.org/simone.tomasi/refid12 2015-11-17T14:56:19Z

Steroid hormones are important players to regulate adult neurogenesis in the dentate gyrus of the hippocampus, but their involvement in the regulation of the same phenomenon in the subventricular zone (SVZ) of the lateral ventricles is not completely understood. Here, in male rats, we tested the existence of activational effects of testosterone (T) on cell proliferation in the adult SVZ. To this a...<br/><br/>A Farinetti, S Tomasi, B Foglio, A Ferraris, G Ponti, S Gotti, P Peretto, G C Panzica (2015) <i>Neuroscience</i> <i></i> <i></i> 286: 162-170<br/>

http://publicationslist.org/simone.tomasi/refid10 2014-02-22T21:51:44Z

The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. Several animal models have been employe...<br/><br/>Natalina Salmaso, Simone Tomasi, Flora M Vaccarino (2014) <i>Clinics in perinatology</i> <i></i> <i></i> 41: 1 229-239<br/>

http://publicationslist.org/simone.tomasi/refid8 2015-11-17T14:57:19Z

The photothrombotic stroke model aims to induce an ischemic damage within a given cortical area by means of photo-activation of a previously injected light-sensitive dye. Following illumination, the dye is activated and produces singlet oxygen that damages components of endothelial cell membranes, with subsequent platelet aggregation and thrombi formation, which eventually determines the interrupt...<br/><br/>Vivien Labat-gest, Simone Tomasi (2013) <i>Journal of visualized experiments : JoVE</i> <i></i> <i></i> : 76 <br/>

http://publicationslist.org/simone.tomasi/refid7 2013-12-15T03:19:48Z

Gyrification allows an expanded cortex with greater functionality to fit into a smaller cranium. However, the mechanisms of gyrus formation have been elusive. We show that ventricular injection of FGF2 protein at embryonic day 11.5-before neurogenesis and before the formation of intrahemispheric axonal connections-altered the overall size and shape of the cortex and induced the formation of promin...<br/><br/>Brian G Rash, Simone Tomasi, H David Lim, Carol Y Suh, Flora M Vaccarino (2013) <i>The Journal of neuroscience : the official journal of the Society for Neuroscience</i> <i></i> <i></i> 33: 26 10802-10814<br/>

http://publicationslist.org/simone.tomasi/refid5 2013-12-15T03:19:48Z

Perinatal hypoxia-ischemia is a major cause of acute mortality in newborns and cognitive and motor impairments in children. Cerebral hypoxia-ischemia leads to excitotoxicity and necrotic and apoptotic cell death, in which mitochondria play a major role. Increased resistance against major damage can be achieved by preconditioning triggered by subtle insults. CO, a toxic molecule that is also genera...<br/><br/>Cláudia S F Queiroga, Simone Tomasi, Marius Widerøe, Paula M Alves, Alessandro Vercelli, Helena L A Vieira (2012) <i>PloS one</i> <i></i> <i></i> 7: 8 <br/>

http://publicationslist.org/simone.tomasi/refid9 2013-12-15T03:19:48Z

Urinary incontinence, defined as the complaint of any involuntary loss of urine, is a pathological condition, which affects 30% females and 15% males over 60, often following a progressive decrease of rhabdosphincter cells due to increasing age or secondary to damage to the pelvic floor musculature, connective tissue and/or nerves. Recently, stem cell therapy has been proposed as a source for cell...<br/><br/>Monica Gunetti, Simone Tomasi, Alessandro Giammò, Marina Boido, Deborah Rustichelli, Katia Mareschi, Edoardo Errichiello, Maurizio Parola, Ivana Ferrero, Franca Fagioli, Alessandro Vercelli, Roberto Carone (2012) <i>PloS one</i> <i></i> <i></i> 7: 9 <br/>

http://publicationslist.org/simone.tomasi/refid6 2013-12-15T03:22:30Z

Cortical areas differ in the size and distribution of neuronal cell bodies, density, and distribution of myelinated axons, connections, and functional properties. We find that they also differ in the diameter of long corticofugal axons, with the thickest axons originating from primary motor, somatosensory, and visual areas and the thinnest ones from prefrontal and temporal areas. Since diameter is...<br/><br/>Simone Tomasi, Roberto Caminiti, Giorgio M Innocenti (2012) <i>Cerebral cortex (New York, N.Y. : 1991)</i> <i></i> <i></i> 22: 6 1463-1472<br/>

http://publicationslist.org/simone.tomasi/refid4 2011-07-27T20:27:19Z

M5 is a mutant of the fibrin-specific proenzyme, single-chain urokinase-type plasminogen activator. M5 has the unusual property that its non-specific two-chain enzymatic form (tcM5) is inhibited rapidly by plasma C1-inhibitor (C1I). As a result, non-specific plasminogen activation, responsible for the hemorrhagic complications of plasminogen activators, can be prevented by C1I. Exceptionally, the ...<br/><br/>S Tomasi, P Sarmientos, G Giorda, V Gurewich, A Vercelli (2011) <i>Stroke</i> <i>International Stroke Conference and Nursing</i> 42: 3 E231-E231<br/>

http://publicationslist.org/simone.tomasi/refid1 2013-12-15T03:22:30Z

A single-site mutant (M5) of native urokinase plasminogen activator (prouPA) induces effective thrombolysis in dogs with venous or arterial thrombosis with a reduction in bleeding complications compared to tPA. This effect, related to inhibition of two-chain M5 (tcM5) by plasma C1-inhibitor (C1I), thereby preventing non-specific plasmin generation, was augmented by the addition of exogenous C1I to...<br/><br/>Simone Tomasi, Paolo Sarmientos, Giada Giorda, Victor Gurewich, Alessandro Vercelli (2011) <i>PloS one</i> <i></i> <i></i> 6: 7 <br/>

http://publicationslist.org/simone.tomasi/refid2 2011-07-27T20:09:35Z

The c-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in ischemic brain injury. The d-retro-inverso form of c-Jun N-terminal kinase-inhibitor (D-JNKI1), a cell-permeable inhibitor of JNK, powerfully reduces neuronal death induced by permanent and transient ischemia, even when administered 6 h after the ischemic insult, offering a clinically relevant window. We investigated the ...<br/><br/>M Repici, C Centeno, S Tomasi, G Forloni, C Bonny, A Vercelli, T Borsello (2007) <i>Neuroscience</i> <i></i> <i></i> 150: 1 40-49<br/>

http://publicationslist.org/simone.tomasi/refid3 2011-07-27T20:10:28Z

Beta-nicotinamidedinucleotide phosphate diaphorase (NADPH-d) colocalizes with NOS in the central nervous system. Two types of NADPH-d-positive neurons are present in the primate cerebral cortex: type 1, intensely and Golgi-like labeled neurons, a subset of GABAergic interneurons; type 2, lightly labeled neurons (divided into two subclasses, a first one having a lightly stained cell body bearing on...<br/><br/>Diego Garbossa, Marco Fontanella, Simone Tomasi, Alessandro Ducati, Alessandro Vercelli (2005) <i>Brain Res</i> <i></i> <i></i> 1034: 1-2 1-10<br/>