Puneetpal Singh's Publications List

A susceptibility putative haplotype within NLRP3 inflammasome gene influences ischaemic stroke risk in the population of Punjab, India.

2022-09-12T07:25:22Z

Despite strong genetic implications of NLRP3 inflammasome, its examination as genetic determinant of ischaemic stroke (IS) remains to be done in Punjab, which has been investigated in this study. In this case control study, 400 subjects (200 IS patients, 200 stroke free controls) were included. Contributions of 5 single nucleotide polymorphisms (SNPs) including a functional SNP within NLRP3 gene (...

Nitin Kumar, Manminder Kaur, Gurjinderpal Singh, Srishti Valecha, Rubanpal Khinda, Mario Di Napoli, Monica Singh, Puneetpal Singh, Sarabjit Mastana (2022) International journal of immunogenetics 49: 4 260-270

Prevalence and Predictors of Osteoporosis and Osteopenia in Postmenopausal Women of Punjab, India.

2022-09-12T07:24:49Z

The prevalence and predictors of osteoporosis and osteopenia remain to be examined in the postmenopausal women of Punjab, India. The present cross-sectional study screened 1628 postmenopausal women during September 2019 to March 2020. Osteoporosis and osteopenia were confirmed on the basis of T-scores using dual energy X-ray absorptiometry (DXA) at the hip (femoral neck) and lumbar spine regions (...

Rubanpal Khinda, Srishti Valecha, Nitin Kumar, J P S Walia, Kuldeep Singh, Sudhir Sethi, Avtar Singh, Monica Singh, Puneetpal Singh, Sarabjit Mastana (2022) International journal of environmental research and public health 19: 5

Genetic Scores of , and Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women.

2021-06-04T04:29:03Z

The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (), angiotensin converting enzyme () and vascular endothelial growth factor () genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without oste...

Puneetpal Singh, Monica Singh, Rubanpal Khinda, Srishti Valecha, Nitin Kumar, Surinderpal Singh, Pawan K Juneja, Taranpal Kaur, Sarabjit Mastana (2021) International journal of environmental research and public health 18: 3

Multifactorial Landscape Parses to Reveal a Predictive Model for Knee Osteoarthritis.

2021-06-04T04:29:33Z

The present study attempted to investigate whether concerted contributions of significant risk variables, pro-inflammatory markers, and candidate genes translate into a predictive marker for knee osteoarthritis (KOA). The present study comprised 279 confirmed osteoarthritis patients (Kellgren and Lawrence scale >2) and 287 controls. Twenty SNPs within five genes (CRP, COL1A1, IL-6, VDR, and eNOS),...

Monica Singh, Srishti Valecha, Rubanpal Khinda, Nitin Kumar, Surinderpal Singh, Pawan K Juneja, Taranpal Kaur, Mario Di Napoli, Jatinder S Minhas, Puneetpal Singh, Sarabjit Mastana (2021) International journal of environmental research and public health 18: 11

Promoter polymorphisms in IL-6 gene influence pro-inflammatory cytokines for the risk of osteoarthritis.

2020-06-16T07:19:10Z

Interleukin-6 (IL-6) gene regulates IL-6 levels, interplay of which has been found to influence pathophysiology of osteoarthritis (OA). Polymorphism within promoter region of IL-6 gene and its association with plasma levels of pro-inflammatory cytokines; IL-6, interleukin 1-beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) remained to be investigated in Punjab region of India, where OA is hig...

Monica Singh, Sarabjit Mastana, Surinderpal Singh, Pawan Kumar Juneja, Taranpal Kaur, Puneetpal Singh (2020) Cytokine 127:

The use of cilostazol for secondary stroke prevention: isn't time to be evaluated in Western countries?

2020-06-16T07:18:43Z

Mario Di Napoli, Puneetpal Singh, Simona Lattanzi, Afshin A Divani (2020) Expert opinion on pharmacotherapy 21: 4 381-387

Investigation of eNOS gene polymorphism exposes a genetic association between endothelial dysfunction and osteoporosis in postmenopausal women.

2020-06-16T07:19:33Z

To investigate the association of genetic polymorphisms of endothelial nitric oxide synthase (eNOS) gene with endothelial dysfunction associated osteoporosis in postmenopausal women of Punjab, India.

Puneetpal Singh, Monica Singh, Srishti Valecha, Rubanpal Khinda, Nitin Kumar, Sarabjit Mastana, Surinderpal Singh, Pawan K Juneja, Taranpal Kaur (2020) Menopause (New York, N.Y.) 27: 6 714-721

Genetic variation and differentiation among a native British and five migrant South Asian populations of the East Midlands (UK) based on CODIS forensic STR loci.

2020-09-03T07:39:49Z

: Short Tandem Repeats (STRs) are widely used in population and forensic genetic studies. The objective of this study was to document the level and extent of genetic variation of the FBI Combined DNA Index System (CODIS) STR loci (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX and CSF1PO) in 6 populations (British, Indian (Punjabis and Gujaratis), Pakistan...

Ella Jane Brearley, Puneetpal Singh, Jasvinder Singh Bhatti, Sarabjit Mastana (2020) Annals of human biology : 1-18

Vitamin D receptor (VDR) gene polymorphism and osteoporosis risk in White British men.

2020-06-16T07:18:11Z

In this study, VDR gene (rs7975232), (rs 1544410) and (rs731236) genotypes were compared in men with osteoporosis and male controls. Osteoporosis affects around 20% of all men and overall mortality in the first year after hip fracture is significantly higher in men than women, yet the genetic basis of osteoporosis is less well studied in males. This study consisted of White British males; 69 os...

Melissa Kow, Elizabeth Akam, Puneetpal Singh, Monica Singh, Nick Cox, Jasvinder Singh Bhatti, Stephen P Tuck, Roger M Francis, Harish Datta, Sarabjit Mastana (2019) Annals of human biology 46: 5 430-433

Monomeric C-Reactive Protein and Cerebral Hemorrhage: From Bench to Bedside.

2018-11-05T04:20:05Z

C-reactive protein (CRP) is an important mediator and a hallmark of the acute-phase response to inflammation. High-sensitivity assays that accurately measure levels of CRP have been recommended for use in risk assessment in ischemic stroke patients. Elevation of CRP during the acute-phase response in intracerebral hemorrhage (ICH) is also associated with the outcomes such as death and vascular com...

Mario Di Napoli, Mark Slevin, Aurel Popa-Wagner, Puneetpal Singh, Simona Lattanzi, Afshin A Divani (2018) Frontiers in immunology 9:

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

2018-11-05T04:20:39Z

Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography.

Rustam Al-Shahi Salman, Joseph Frantzias, Robert J Lee, Patrick D Lyden, Thomas W K Battey, Alison M Ayres, Joshua N Goldstein, Stephan A Mayer, Thorsten Steiner, Xia Wang, Hisatomi Arima, Hitoshi Hasegawa, Makoto Oishi, Daniel A Godoy, Luca Masotti, Dar Dowlatshahi, David Rodriguez-Luna, Carlos A Molina, Dong-Kyu Jang, Antonio Davalos, José Castillo, Xiaoying Yao, Jan Claassen, Bastian Volbers, Seiji Kazui, Yasushi Okada, Shigeru Fujimoto, Kazunori Toyoda, Qi Li, Jane Khoury, Pilar Delgado, José Álvarez Sabín, Mar Hernández-Guillamon, Luis Prats-Sánchez, Chunyan Cai, Mahesh P Kate, Rebecca McCourt, Chitra Venkatasubramanian, Michael N Diringer, Yukio Ikeda, Hans Worthmann, Wendy C Ziai, Christopher D d'Esterre, Richard I Aviv, Peter Raab, Yasuo Murai, Allyson R Zazulia, Kenneth S Butcher, Seyed Mohammad Seyedsaadat, James C Grotta, Joan Martí-Fàbregas, Joan Montaner, Joseph Broderick, Haruko Yamamoto, Dimitre Staykov, E Sander Connolly, Magdy Selim, Rogelio Leira, Byung Hoo Moon, Andrew M Demchuk, Mario Di Napoli, Yukihiko Fujii, Craig S Anderson, Jonathan Rosand, , (2018) The Lancet. Neurology 17: 10 885-894

Genetic variation of MHC Class I polymorphic Alu insertions (POALINs) in three sub-populations of the East Midlands, UK.

2017-08-04T07:10:34Z

Genetic variation of MHC Class I polymorphic Alu insertions (POALINs) in three sub-populations of the East Midlands, UK. Mastana SS1, Bhatti JS2, Singh P3, Wiles A1, Holland J1. Author information Abstract BACKGROUND: Alu elements are highly researched due to their useful nature as markers in the study of human population genetics. Recently discovered Major Histocompatibility Complex (MHC) ...

Sarabjit S Mastana, Jasvinder S Bhatti, Puneetpal Singh, Adam Wiles, Jonathan Holland (2017) Annals of human biology : 1-6

Pain: Causes, Concerns and Consequences

2017-08-04T07:21:29Z

Pain: Causes, Concerns and Consequences Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending inju...

Puneetpal Singh and Monica Singh (2017) :

The Role of TLR4, TNF-α and IL-1β in Type 2 Diabetes Mellitus Development within a North Indian Population.

2017-08-04T07:08:22Z

This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL-1β-511, TLR4-896 and TNF-α-308 loci. The C allele of IL-1β-511 was shown to increase T2D...

Natalie E Doody, Monika M Dowejko, Elizabeth C Akam, Nick J Cox, Jasvinder S Bhatti, Puneetpal Singh, Sarabjit S Mastana (2017) Annals of human genetics 81: 4 141-146

A hybrid cardiac rehabilitation is as effective as a hospital-based program in reducing chest pain intensity and discomfort.

2018-11-05T04:19:17Z

Health care services effort to provide alternative cardiac rehabilitation (CR) models to serve patients according to their preferences and needs. So, the present study aimed to assess and compare the effects of hospital-based and hybrid CR programs on chest pain intensity and discomfort in cardiac surgery patients.

Mozhgan Saeidi, Ali Soroush, Saeid Komasi, Puneetpal Singh (2017) The Korean journal of pain 30: 4 265-271

Genetic analysis of novel Alu insertion polymorphisms in selected indian populations.

2017-08-04T07:04:40Z

Abstract OBJECTIVES: Indian subpopulations (Chenchu, Koya, and Lobana Sikh) were analyzed at the genetic level for 12 Alu polymorphisms. These markers were then utilized to establish levels of genetic identity between the Indian populations and more widely between the Indian populations and a European population. METHODS: Previously collected blood samples were extracted using the phenol-chlor...

Susie Laybourn, Elizabeth Claire Akam, Nick Cox, Puneetpal Singh, Sarabjit S Mastana (2016) American journal of human biology : the official journal of the Human Biology Council 28: 6 941-944

The Prevalence and Predictors of Depression in Type 2 Diabetic Population of Punjab.

2017-08-04T07:27:51Z

The present cross sectional study was carried out on 787 type 2 diabetic subjects from tertiary health care hospitals to identify the prevalence and predictors of depression in diabetes. Depression was tested using Patient Health Questionnaire-9. Of the study participants, 199 (25.29%) met the criteria for mild to moderate depression, 252 (32.02%) were severely depressed and 336 (42.69%) were clin...

Shallu Khullar, Harjot Dhillon, Gurpreet Kaur, Ritu Sharma, Kanchan Mehta, Rohit Aggarwal, Monica Singh, Puneetpal Singh (2016) Community mental health journal 52: 4 479-483

Depression: A Silent Culprit in Health and Disease

2017-08-04T07:24:39Z

Depression is considered as a complex problem with potentially serious economic consequences for affected individuals as well as public healthcare systems. There is much debate among laypersons, patients, academics and clinicians about the causes of depression, its clinical significance and the effect of conventional medical interventions such as antidepressants. This monograph showcases some aspe...

(2015) :

Diabetes to cardiovascular disease: is depression the potential missing link?

2016-01-16T07:43:06Z

The etiopathological consequences of diabetes and its imperative sequels have been explored extensively in the scientific arena of cardiovascular diabetology. Innumerable risk covariates and confounders have been delineated for the primary and secondary prevention of diabetes and cardiovascular diseases (CVD). However, an intricate interaction of depression on them has been largely overlooked. Dep...

Puneetpal Singh, Shallu Khullar, Monica Singh, Gurpreet Kaur, Sarabjit Mastana (2015) Medical hypotheses 84: 4 370-378

C-reactive protein predicts hematoma growth in intracerebral hemorrhage.

2013-12-28T15:16:21Z

Early hematoma growth (EHG) occurs in about one third of patients with spontaneous intracerebral hemorrhage. The main aim of this study was to investigate the potential of plasma C-reactive protein (CRP) for predicting EHG after acute spontaneous intracerebral hemorrhage.

Mario Di Napoli, Adrian R Parry-Jones, Craig J Smith, Stephen J Hopkins, Mark Slevin, Luca Masotti, Veronica Campi, Puneetpal Singh, Francesca Papa, Aurel Popa-Wagner, Valerica Tudorica, Daniel Agustin Godoy (2014) Stroke; a journal of cerebral circulation 45: 1 59-65

A novel haplotype within C-reactive protein gene influences CRP levels and coronary heart disease risk in Northwest Indians.

2014-07-15T07:18:56Z

According to several epidemiological and clinical studies, the concentration of C-reactive protein (CRP) in blood is associated with the risk of coronary heart disease (CHD). However, these studies are limited in high incidence and prevalence area of North-West India. The present case control study investigated the contribution of three relevant CRP single nucleotide polymorphisms: -717A>G located...

Puneetpal Singh, Monica Singh, Harinder Singh Nagpal, Taranpal Kaur, Shallu Khullar, Gurpreet Kaur, Harjot Dhillon, Mario Di Napoli, Sarabjit Mastana (2014) Molecular biology reports :

Vitamin D receptor (VDR) gene polymorphism influences the risk of osteoporosis in postmenopausal women of Northwest India.

2013-12-28T15:15:24Z

The influence of VDR gene for the risk of osteoporosis has remained inconclusive. VDR gene polymorphism in relation to BMD in postmenopausal women of Northwest India revealed a susceptibility haplotype AGT. Possession of this haplotype exacerbates the risk of osteoporosis by 2.8 times, which manifests in recessive mode of inheritance.

Monica Singh, Puneetpal Singh, Surinder Singh, Pawan Kumar Juneja, Taranpal Kaur (2013) Archives of osteoporosis 8: 1-2

A susceptibility haplotype within the endothelial nitric oxide synthase gene influences bone mineral density in hypertensive women.

2013-12-28T15:15:54Z

The influence of the coordinated effect of various single-nucleotide polymorphisms (SNPs) within the endothelial nitric oxide synthase (eNOS) gene on the risk of osteoporosis in hypertension has remained undetermined. Four pertinent SNPs of the eNOS gene, rs2070774, rs1799983, rs1800780 and rs3918181, were examined for the risk of osteoporosis in 313 hypertensive postmenopausal women in Northwest ...

Monica Singh, Puneetpal Singh, Surinder Singh, Pawan Kumar Juneja, Taranpal Kaur (2013) Journal of bone and mineral metabolism :

A haplotype derived from the common variants at the -1997G/T and Sp1 binding site of the COL1A1 gene influences risk of postmenopausal osteoporosis in India.

2013-12-28T15:13:39Z

The aim of the present study was to investigate the association between Collagen 1 alpha 1 (COL1A1) polymorphism and osteoporosis in DEXA verified 349 (145 osteoporotic, 87 osteopenic and 117 normal) postmenopausal women of India, who were not taking hormone replacement therapy. Two single-nucleotide polymorphisms (SNPs), that is, -1997G/T (rs1107946) and +1245G/T (rs1800012, Sp1) of the COL1A1 ge...

Monica Singh, Puneetpal Singh, Surinder Singh, Pawan Kumar Juneja, Taranpal Kaur (2013) Rheumatology international 33: 2 501-506

Letter by Singh et al regarding article, "Apolipoprotein isoform e4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations".

2013-12-28T15:19:06Z

Puneetpal Singh, Mario Di Napoli, Monica Singh (2012) Circulation. Cardiovascular genetics 5: 2

Letter by Singh et al regarding article, "Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the GOLDN study".

2013-12-28T15:19:34Z

Puneetpal Singh, Mario Di Napoli, Monica Singh (2011) Circulation. Cardiovascular genetics 4: 1

Role of C-reactive protein in cerebrovascular disease: a critical review.

2013-12-28T15:18:31Z

C-reactive protein (CRP) is a blood marker of inflammation and a hallmark of the acute-phase response. Its elevation bears negative prognostic implications for many conditions and it has also been shown to be a nonspecific predictor of long-term risk of cerebrovascular disease (CVD) in several populations, while elevations of CRP associated with the major acute-phase response following ischemic or...

Mario Di Napoli, Mitchell S V Elkind, Daniel Agustin Godoy, Puneetpal Singh, Francesca Papa, Aurel Popa-Wagner (2011) Expert review of cardiovascular therapy 9: 12 1565-1584

Role and Relevance of Factor VIII Gene Haplotyping for the Indirect Genetic Analysis of Carrier Diagnosis in Hemophilia

2012-12-16T02:07:09Z

Hemophilia A is an X-linked recessive coagulation disorder because of the quantitative or qualitative deficiency of blood coagulation factor VIII (FVIII). Molecular genetic analysis; that is, direct mutation detection and linkage analysis of restriction markers, contribute effectively for the carrier detection in hemophilia. Due to the large size of FVIII gene (186 Kb), direct mutation analysis ...

Singh M, Singh PP (2010) Journal of Coagulation Disorders :

SNP-SNP interactions within APOE gene influence plasma lipids in postmenopausal osteoporosis.

2010-03-28T13:31:50Z

Monica Singh, Puneetpal Singh, Pawan Kumar Juneja, Surinder Singh, Taranpal Kaur (2010) Rheumatol Int :

A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India.

2010-08-16T04:29:18Z

BACKGROUND: The association of apolipoprotein E (APOE) genotypes with bone mineral density (BMD) and risk of osteoporosis have remained unclear. The influence of APOE gene polymorphisms on BMD as genetic mediators of osteoporosis risk needs to be explored in Indian postmenopausal females where this disease is rising rampantly. METHODS AND RESULTS: The present study investigated the role and releva...

Monica Singh, Puneetpal Singh, Surinder Singh, Pawan Kumar Juneja, Taranpal Kaur (2010) Maturitas :

Factor VIII gene haplotypes and linkage disequilibrium for the indirect genetic analysis of hemophilia A in India.

2009-10-09T12:24:40Z

Genomic consequences of factor VIII gene haplotypes for the indirect genetic analysis of haemophilia A has not been done in India hitherto. Consequently, BclI/intron18, HindIII/intron 19, and XbaI/intron 22 restriction sites were investigated in 159 individuals from 42 families with hemophilia A. The frequencies of haplotype II, IV, VI, that is, BclI (+)-HindIII (-)- XbaI (+), BclI (+)HindIII (+)-...

Monica Singh, Puneetpal Singh (2009) Clin Appl Thromb Hemost 15: 3 334-339

Is plasma fibrinogen useful in evaluating ischemic stroke patients?: why, how, and when.

2009-10-09T12:26:58Z

Mario Di Napoli, Puneetpal Singh (2009) Stroke 40: 5 1549-1552

Role of apolipoproteins E and A-I: Epistatic villains of triglyceride mediation in coronary heart disease.

2009-10-09T12:26:00Z

The epistatic effects of ApoE (HhaI) and ApoA-I (PstI) genes as the genetic modulators of lipid levels were investigated in 165 angiographically verified CHD patients and 120 controls of Punjab, a northwest province of India. It has been revealed that of all the genotypic combinations of ApoE and ApoA-I, E4 allele carriers (E4+) with P1P2 genotype (ApoA-I/PstI) had higher risk of CHD (OR 2.99, CI ...

Puneetpal Singh, Monica Singh, Taranpal Kaur (2009) Int J Cardiol 134: 3 410-412

Apolipoprotein C3 (SstI) gene variability in Northwest India: a global perspective.

2009-10-06T06:15:38Z

ABSTRACT Apolipoprotein C3 plays an important role in the receptor mediated hydrolysis of triglyceride rich lipoproteins (TRLs) by inhibition of lipoprotein lipase (LPL), delayed clearance of which causes hypertriglyceridemia (HTG). Indians are considered to be more vulnerable to the adverse effects of hypertriglyceridemia and consequently its probable sequel of cardiovascular disorders. Sever...

Singh PP, Singh M, Bhatnagar, DP, Mastana S. (2008) Int J Hum Genet. 8: 51-60

Factor IX gene haplotypes and its relevance for the indirect genetic analysis of haemophilia B in its Indian perspective.

2009-10-09T12:25:10Z

In developing countries, especially in those with limited facilities and low budget resources, a reliable approach to carrier detection and prenatal diagnosis of haemophilia B might be based on indirect diagnostic strategies. As, the cost-effectiveness of indirect genetic analysis of haemophilia B has been little investigated so far, we here report our experience in India. Polymerase chain reactio...

Monica Singh, Puneetpal Singh (2008) Blood Coagul Fibrinolysis 19: 5 429-432

Apolipoprotein E polymorphism and its relation to plasma lipids in coronary heart disease.

2009-10-09T12:25:42Z

BACKGROUND : The present investigation is aimed at examining the Apolipoprotein E (APOE) genotypic influence on coronary heart disease (CHD) risk in northwest India (Punjab), where this disease is emerging as a major threat to public-health care system. MATERIALS AND METHODS: The present study comprised of angiographically diagnosed coronary heart disease patients (n = 193) and controls (n = 150) ...

P P Singh, M Singh, D P Bhatnagar, T P Kaur, S K Gaur (2008) Indian J Med Sci 62: 3 105-112

A novel haplotype in ApoAI-CIII-AIV gene region is detrimental to Northwest Indians with coronary heart disease.

2009-10-09T12:26:28Z

The present study investigated the genetic variation of 3' flanking region of ApoA-I (PstI), 3' untranslated region of ApoC-III (SstI) and intron 2 of ApoA-IV (XbaI) in 193 angiographically diagnosed CHD patients and 150 CHD negative controls of Punjab, Northwest India. Haplotype analysis reveals that P2-S2-X1 is a susceptibility haplotype that confers the risk of CHD (OR 2.33, CI 1.08-4.38, P<0.0...

Puneetpal Singh, Monica Singh, T P Kaur, S S Grewal (2008) Int J Cardiol 130: 3 e93-e95

Plasma protein variations in hemophiliacs receiving factor replacement therapy.

2009-10-09T12:27:18Z

OBJECTIVE: Post transfusion manifestations and its affiliated factors are vital to understand in a disease like hemophilia where multi-transfusions are given to the patients. METHODS: To investigate the implications of factor replacement therapy on plasma proteins, 52 hemophiliacs and 68 carrier females were examined for 12 plasma proteins using various electrophoretic techniques. RESULTS: Severe ...

Monica Singh, Puneetpal Singh, Harsurinder Kaur (2007) Indian J Pediatr 74: 5 459-462

The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype.

2009-10-09T12:23:09Z

The present study investigated genetic variation in the 3' flanking region of ApoA-I (PstI), the 3' untranslated region of ApoC-III (SstI) and intron 2 of ApoA-IV (XbaI) in 435 type 2 diabetes mellitus patients, divided according to the presence or absence of coronary heart disease (CHD). Uncommon allele frequencies (P2, S2, X2) were 17.5%, 32.5%, 16.2% and 29.5%, 17.9%, 13.8% in patients with and...

Puneetpal Singh, Monica Singh, Sunil Gaur, Taranpal Kaur (2007) Diab Vasc Dis Res 4: 2 124-129

Association of APOE (HhaI)and ACE (I/D) gene polymorphism with type 2 diabetes mellitus in North West India.

2009-10-09T12:20:40Z

Familial and epidemiological studies have shown that genetic factors play a role in the development and progression of type 2 diabetes mellitus (T2DM). Asian Indians have shown an increasing prevalence of T2DM. Apolipoprotein E (APOE) and Angiotensin-1 converting enzyme (ACE) I/D polymorphisms have been associated with T2DM. This study examined the association of APOE and ACE genes with T2DM patie...

Singh, P.P., Naz, I., Gilmour, A., Singh, M and Mastana, S. (2006) Diab Res Clin Pract: 74: 1 95-102

APOE distribution in world populations with new data from India and the UK.

2009-10-09T12:22:15Z

BACKGROUND: The APOE gene and its protein product is associated with a number of plasma proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) chylomicrons, chylomicron remnants, and plays a crucial role in lipid metabolism. The APOE gene is polymorphic and common alleles (*E2, *E3 and *E4) have been associated with a number of common and complex diseases in different po...

Singh, P.P., Singh, M., Mastana, S. (2006) Ann Hum Biol 33: 3 279-308

Apolipoprotein A-I(PstI) polymorphism in two populations of Punjab.

2009-10-05T08:16:34Z

Singh, P.P., Bhatnagar, D.P. (2005) Ind J Phy Anth & Hum Genet 24: 1-5

Estimation of immunoglobulin IgG in haemophiliacs receiving factor replacement therapy.

2009-10-05T08:17:42Z

Singh, M., Singh, P.P., Bhatnagar, D.P., Kaur H. (2005) Ind J Phy Anth & Hum Genet 24: 57-60

Overview of issues and problems in the delivery of Haemophilia care and management.

2009-10-05T08:13:13Z

Singh, P.P., Singh, M.,Mastana, S.S., Bhatnagar, D.P (2003) Biospectrum. 1: 2 32-35

Coronary heart disease: window on a possible marker and its futuristic view point.

2009-10-05T08:25:04Z

Singh, P.P., Singh, M., Bhatnagar, D.P.,Mastana, S.S. (2003) Biospectrum. 1: 2 80-82

Molecular Phylogenetics: An Important Trajectory of Bioinformatics.

2009-10-06T06:16:52Z

Singh, P.P. (2003) Bioinformatics India 1: 2 79-83

Genetic analysis of atherosclerosis- apolipoproteins, LDL-R, LPL as biomarkers.

2009-10-05T08:14:21Z

Singh, P.P. and Singh,M. (2003) Ind J Phy Anth & Hum Genet 1: 1-13

Role of inflammatory factors in coronary atherogenesis: an assessment of some indicators for future research.

2009-10-05T08:15:32Z

Singh, P.P., Singh, M., Bhatnagar, D.P., Mastana, S.S and Gerdes, U. (2003) Ind J Phy Anth & Hum Genet 2: 155-162

Molecular variation in the East Midlands, England-analysis of VNTR, STR and Alu Insertion/deletion polymorphism.

2009-10-09T12:12:00Z

BACKGROUND: Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) have been used successfully in disease analysis and studies of human evolution and population genetic diversity. However DNA-based comprehensive population genetic studies of the East Midlands, England are limited. SUBJECTS AND METHODS: To enlarge our understanding of genetic variation in the East Midlands, a stu...

Mastana,S.S., Lee,D.R., Singh PP., Singh M. (2003) Ann Hum Biol 30: 538-550

Genetics of apolipoprotein H (Beta2-glycoprotein I)polymorphism in India.

2009-10-09T12:17:39Z

BACKGROUND: Human apolipoprotein H (beta(2)-glycoprotein I, apoH, protein; APOH, gene) is a single-chain glycoprotein that has been implicated in several metabolic pathways, including lipid metabolism, coagulation and production of antiphospholipid antibodies and many disease phenotypes. The structural, molecular and genetic bases of APOH have been studied in detail but population studies, especia...

Singh P.P., Singh, M., Mastana, S.S. (2002) Ann Hum Biol 29: 3 247-255

Genetic heterogeneity of apoCII locus in North India.

2009-10-09T12:19:14Z

Apolipoprotein CII genotypes were determined in Brahmins, Banias, Jat Sikhs, Khatris, Ramgarhia, Ramdasia and Scheduled Castes of Punjab, North India (n = 930). The Apo CII exhibits three common polymorphic alleles CII*1, CII*2 and CII*3 with pooled frequencies 0.883, 0.114 and 0.003, respectively. CII*3 was absent in Brahmins. Distribution of Apo CII isoforms highlights a considerable variation a...

Singh, P.P., Singh, M., Mastana, S.S. (2002) Anthrop Anz 60: 27-34

S.S.Overview of AIDS-an update

2009-10-05T08:24:16Z

Singh, P.P.,Singh M, Mastana, S.S (2002) Journal of Punjab Academy of Sciences 1: 81-87

Genetic variation of apolipoproteins In North India.

2009-10-09T12:16:03Z

Genetic variation at three apolipoprotein loci (APOA4, APOH, and APOE) has been examined in nine endogamous populations of Punjab, North India. The overall pattern of allele frequency variation at different loci is compatible with that of European populations, but observed microvariation differentiates the populations according to their position in the Indian caste structure. The most common allel...

Singh, P.P., Singh, M. and Mastana, S.S. (2002) Human Biology. 74: 5 673-682

Population genetic study of the STR loci(CSF1PO, TPOX,THO1, LPL, F13AO1, F13B, HSFESFPS) in North Indians.

2009-10-09T12:14:10Z

BACKGROUND: Highly polymorphic genetic markers like short tandem repeats (STRs) have been used successfully in disease analysis and studies of human evolution and population genetic diversity. However, DNA-based population genetic studies of Indian populations are limited. SUBJECTS AND METHODS: To enlarge our understanding of genetic variation in Indian populations, a population genetic study was ...

Mastana,S.S and Singh, P.P. (2002) Ann Hum Biol 29: 6 677-684

Dynamics of Molecular genetic diversity in East Midlands (UK) and paternity implications.

2009-10-06T06:17:53Z

Mastana,S.S., Lee, D.R., Singh, P.P. Singh, M. (2002) Inter J Hum Genet 2: 4 261-264

Genetic heterogeneity of Beta 2 - Glycoprotein I (Apo-H) in Ramgarhias and Ramdaias of Punjab-First report from North India.

2009-10-05T08:06:36Z

Singh, P.P., Singh, M. and Singhal, P. (2001) South Asian Anthropologist 1: 1 1-5

Human apolipoprotein A-IV polymorphism in two caste groups of Punjab-First report from North India. Nucleus. 44 (1,2) : 2001. 97-101.

2009-10-05T08:09:07Z

Singh, P.P., Singh, M. and Mastana, S.S. (2001) Nucleus. 44: 1,2 97-101

Probing AIDS awareness in Internet Savoir Faire.

2009-10-05T08:07:46Z

Singh, P.P., Singh, M. and Mastana, S.S. (2001) South Asian Anthropologist 1: 2 113-116

Apolipoprotein E polymorphism in India : High frequency of the Apo Epsilon*3 allele in Ramgarhias of Punjab.

2009-10-06T06:25:39Z

High resolution two dimensional gel electrophoresis with the combination of isoelectric focusing (IEF) and density gradient sodium dodecyl-polyacrylamide gel electrophoresis (DG-PAGE) have been employed to investigate the distribution of APOE in Ramgarhia (n = 80) and Ramdasia (n = 70) of Punjab, India. Three alleles APOE*E2, APOE*E3 and APOE*E4 were observed in Ramgarhia and Ramdasia with the fre...

Singh, P.P., Singh, M.,Gerdes, L.U.,Mastana, S.S (2001) Anthrop.Anz. 59: 1 27-34

Apolipoprotein A-IV polymorphism in five Punjabi populations : Gene frequencies and Gene diversities.

2009-10-05T08:01:00Z

Singh, P.P., Singh, M. and Singh, S.S (2000) The Anthropologist 2: 4 147-151

Do distances play role in AIDS info ? Decreasing vigilance towards countryside.

2009-10-05T08:02:44Z

Singh, P.P., Singh, M. and Singh, S.S. (2000) The Anthropologist 2: 4 253-255

AIDS Hullabaloo : Increasing vigilance in convent tutors.

2009-10-05T08:04:40Z

Singh, P.P., Singh, M. and Mastana, S.S (2000) Dis.& Imp. 14: 2 73-77

Genetic evaluation of plasma proteins by two dimensional gel electrophoresis.

2009-10-05T08:21:02Z

Singh, P.P., Singh, M. and Kaur, K. (2000) The Anthropologist. 2: 2 77-85

Apolipoprotein polymorphism in man-it’s role in health and disease

2009-10-05T07:50:55Z

Singh, P.P., Balgir, P.P., Bansal, I.J.S and Singh, M. (1999) The Anthropologist 1: 2 103-108

Genetic analysis of plasma apo C-II by two dimensional gel electrophoresis in two population groups of Punjab.

2009-10-05T07:52:40Z

Singh, P.P., Singh, M. and Mastana, S.S (1999) Ind. J. Hum. Genet. 5: 2 1-4

Study of some morphological, physiological and serological parameters in twins.

2009-10-05T08:26:12Z

Singh M., Singh S.P., Kaur, H., Singh P.P. (1999) The Anthropologist 1: 4 261-264

Menarcheal status and physical structure of Punjabi girls

2009-10-05T05:59:50Z

Singh SP, Singh PP,Bala M. (1998) J. Hum. Ecol. 9 : 1 4752

Apolipoproteins and Cardiovascular diseases-an overview

2009-10-05T07:44:58Z

Singh, P.P., Singh, M. and Singh S (1998) Indian Anthropoligist 11: 1 61-71

Genetic Hetrogeneity of apolipoprotein E-it’s role in Health and Disease

2009-10-05T05:16:02Z

Balgir, P.P.,Singh, P.P. and Bansal, I.J.S (1997) Bionature. 170 : 35-42

Age of eruption of primary teeth in khatri boys of Punjab

2009-10-05T05:13:07Z

Singh PP,Singh S P (1995) J.Ind.Anth. Soc. 30 : 273-277