Blot Stijn's Publications List

Antimicrobial prophylaxis in liver transplant patients - a multicenter survey endorsed by the European Liver and Intestine Transplant Association

2010-02-08T14:03:39Z

P>Perioperative infections remain an important problem for patients undergoing liver transplantation (LT). For prevention of these infections, perioperative prophylaxis has become the standard procedure. Yet, either guidelines or data on current practice are lacking. The aim of the study was to gain insight into prophylactic antimicrobial strategies used in Europe. A survey questionnaire was sent ...

E Vandecasteele, J De Waele, D Vandijck, S Blot, D Vogelaers, X Rogiers, H Van Vlierberghe, J Decruyenaere, E Hoste (2010) TRANSPLANT INTERNATIONAL 23: 19 182-190

Replacement of Administration Sets Used to Administer Blood, Blood Products, or Lipid Emulsions for the Prevention of Central Line-Associated Bloodstream Infection

2010-02-08T14:03:39Z

S Labeau, D Vandijck, C Lizy, A Piette, G Verschraegen, D Vogelaers, S Blot (2009) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 30: 7 494-494

Epidemiology and outcome of nosocomial bloodstream infection in elderly critically ill patients : A comparison between middle-aged, old, and very old patients

2010-02-08T14:03:39Z

Background: We investigated the epidemiology of nosocomial bloodstream infection in elderly intensive care unit (ICU) patients. Methods: In a single-center, historical cohort study (19922006), we compared middle-aged (45-64 years; n = 524), old (65-74 years; n = 326), and very old ICU patients (>= 75 years; n = 134) who developed a nosocomial bloodstream infection during their ICU stay. Results: A...

S Blot, M Cankurtaran, M Petrovic, D Vandijck, C Lizy, J Decruyenaere, C Danneels, K Vandewoude, A Piette, G Vershraegen, N Van Den Noortgate, R Peleman, D Vogelaers (2009) CRITICAL CARE MEDICINE 37: 54 1634-1641

Temporal trends, risk factors and outcomes in albicans and non-albicans candidaemia : an international epidemiological study in four multidisciplinary intensive care units

2010-02-08T14:03:39Z

This multicentre study (i) evaluated geographic and temporal changes in candidaemia ecology in the critically ill, (ii) identified risk factors associated with non-albicans candidaemia and (iii) examined the association of Candida ecology with mortality. A retrospective cohort study of patients who developed candidaemia in four general Intensive Care Units located in Australia, Greece, Belgium and...

A Holley, J Dulhunty, S Blot, J Lipman, S Lobo, C Dancer, J Rello, G Dimopoulos (2009) INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 33: 43 -

Enterobacteriaceae bacteremia after liver transplantation

2010-02-08T14:03:39Z

D Vandijck, E Hoste, D Vogelaers, S Blot (2009) TRANSPLANT INTERNATIONAL 22: 15 354-355

Development and validation of a model for prediction of mortality in patients with acute burn injury

2010-02-08T14:03:39Z

Background: The objective was to develop a user-friendly model to predict the probability of death from acute burns soon after injury, based on burned surface area, age and presence of inhalation injury. Methods: This population-based cohort study included all burned patients admitted to one of the six Belgian burn centres. Data from 1999 to 2003 (5246 patients) were used to develop a mortality pr...

S Blot, N Brusselaers, S Monstrey, K Vandewoude, J J De Waele, K Colpaert, J Decruyenaere, M Malbrain, C Lafaire, J P Fauville, S Jennes, M P Casaer, J Muller, D Jacquemin, D De Bacquer, E Hoste (2009) BRITISH JOURNAL OF SURGERY 96: 19 111-117

Radiologic Progression of Pulmonary Infiltrates Predicts a Worse Prognosis in Severe Community-Acquired Pneumonia Than Bacteremia

2010-02-08T14:03:39Z

Background: It remains unknown whether bacteremia and rapid radiologic progression of pulmonary. infiltrates increase the risk of shock and mortality in ICU patients with community-acquired pneumonia (CAP). The objective of this study was to investigate the relative importance of these two factors in the outcome of patients with severe CAP (sCAP). Methods: A secondary analysis in a multicenter obs...

T Lisboa, S Blot, G W Waterer, E Conalis, D de Mendoza, A Rodriguez, J Rello (2009) CHEST 135: 18 165-172

Centers for Disease Control and Prevention guidelines for preventing central venous catheter-related infection : Results of a knowledge test among 3405 European intensive care nurses

2010-02-08T14:03:39Z

Objective: To determine European intensive care unit (ICU) nurses' knowledge of guidelines for preventing central venous catheter-related infection from the Centers for Disease Control and Prevention. Design: Multicountry survey (October 2006-March 2007). Setting: Twenty-two European countries. Participants: ICU nurses. Measurements and Main Results: Using a validated multiple-choice test, knowled...

S O Labeau, D M Vandijck, J Rello, S Adam, A Rosa, C Wenisch, C Backman, K Agbaht, A Csomos, M Seha, G Dimopoulos, K H Vandewoude, S I Blot (2009) CRITICAL CARE MEDICINE 37: 19 320-323

The FLAMES Score Accurately Predicts Mortality Risk in Burn Patients (Gomez M, et al. 2008)

2010-02-08T14:03:39Z

N Brusselaers, S Monstrey, S Blot (2009) JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 67: 9 415-415

Mortality in ICU patients with bacterial community-acquired pneumonia : when antibiotics are not enough

2010-02-08T14:03:39Z

It remains uncertain why immunocompetent patients with bacterial community-acquired pneumonia (CAP) die, in spite of adequate antibiotics. This is a secondary analysis of the CAPUCI database which was a prospective observational multicentre study. Two hundred and twelve immunocompetent patients admitted to 33 Spanish ICUs for CAP were analyzed. Comparisons were made for lifestyle risk factors, com...

A Rodriguez, T Lisboa, S Blot, I Martin-Loeches, J Sole-Violan, D De Mendoza, J Rello (2009) INTENSIVE CARE MEDICINE 35: 35 430-438

Risk factors and outcome in extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae bacteremia

2010-02-08T14:03:39Z

S Blot (2009) SAUDI MEDICAL JOURNAL 30: 0 1366-1366

Implementation of an evidence-based sepsis program in the intensive care unit : evident or not?

2010-02-08T14:03:39Z

Severe sepsis and septic shock are among the most serious health conditions and are associated with unwelcome clinical, social, and economic outcomes. With the introduction of the Surviving Sepsis Campaign guidelines, the campaign leaders aimed to reduce mortality from severe sepsis by at least one quarter by 2009 by means of a six-point action plan, namely, building awareness among health care pr...

D M Vandijck, S I Blot, D P Vogelaers (2009) CRITICAL CARE 13: 17 -

Reduction of ventilator-associated pneumonia : enhancing knowledge is important

2010-02-08T14:03:39Z

S O Labeau, D M Vandijck, N Brusselaers, D De Wandel, D P Vogelaers, S I Blot (2009) INTENSIVE CARE MEDICINE 35: 5 1818-1819

Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections

2010-02-08T14:03:39Z

D M Vandijck, S O Labeau, N Brusselaers, D De Wandel, D P Vogelaers, S I Blot (2009) CRITICAL CARE MEDICINE 37: 6 2998-2999

Evaluation of mortality following severe burns injury in Hungary : External validation of a prediction model developed on Belgian burn data

2010-02-08T14:03:39Z

Purpose: To evaluate mortality in a group of Hungarian burn patients and, as such, to perform an external validation of a prediction model developed on Belgian burn data by which the mortality appraisal was executed. Basic procedures: In a historical cohort we analysed all burn patients admitted between 1998 and 2006 to the Debrecen University Hospital (n = 2326). The prediction model, based on th...

N Brusselaers, I Juhasz, I Erdei, S Monstrey, S Blot (2009) BURNS 35: 29 1009-1014

Hospital Costs in Patients with Nosocomial Methicillin-Resistant or Methicillin-Susceptible Staphylococcus aureus Bloodstream Infection

2010-02-08T14:03:39Z

D M Vandijck, L Annemans, D P Vogelaers, S I Blot (2009) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 30: 9 1127-1127

Incidence and mortality of systemic fungal infection in burned patients

2010-02-08T14:03:39Z

A Piette, S Blot, K Vandewoude, D Vogelaers (2009) BURNS 35: 8 1052-1053

Oral Care, Ventilator-Associated Pneumonia, and Counting Cultures

2010-02-08T14:03:39Z

C Lizy, N Brusselaers, S Labeau, D Vandijck, D De Wandel, D Vogelaers, S Blot (2009) AMERICAN JOURNAL OF CRITICAL CARE 18: 17 507-508

Costs and length of stay associated with antimicrobial resistance in acute kidney injury patients with bloodstream infection

2010-02-08T14:03:39Z

Introduction: Antimicrobial resistance negatively impacts on prognosis. Intensive care unit (ICU) patients, and particularly those with acute kidney injury (AKI), are at high risk for developing nosocomial bloodstream infections (BSI) due to multi-drug-resistant strains. Economic implications in terms of costs and length of stay (LOS) attributable to antimicrobial resistance are underevaluated. Th...

D M Vandijck, S I Blot, J M Decruyenaere, R C Vanholder, J J De Waele, N H Lameire, S Claus, J De Schuijmer, A W Dhondt, G Verschraegen, E A Hoste (2008) ACTA CLINICA BELGICA 63: 43 31-38

Hyperglycaemia upon onset of ICU-acquired bloodstream infection is associated with adverse outcome in a mixed ICU population

2010-02-08T14:03:39Z

This study aimed to assess whether a relationship exists between hyperglycaemia and outcome in a mixed cohort of critically ill patients with nosocomial bloodstream infection (BSI), and to evaluate patterns of blood glucose levels between survivors and non-survivors. A historical observational cohort study was conducted in the intensive care unit (ICU) of a tertiary care referral centre. One-hundr...

D M Vandijck, S G Oeyen, E M Buyle, B O Claus, S I Blot, J M Decruyenaere (2008) ANAESTHESIA AND INTENSIVE CARE 36: 23 25-29

Systematic surveillance cultures as a toolto predict involvement of multidrug antibiotic resistant bacteria in ventilator-associated pneumonia

2010-02-08T14:03:39Z

Objective: To assess prediction of multidrug resistant (MDR) pathogens in ventilator-associated pneumonia (VAP) by systematic surveillance cultures (SC) and to assess the contribution of SC to initial antibiotic therapy. Design: Prospective cohort study of patients with microbiologically confirmed VAP. Comparison of actual early antibiotic coverage with three hypothetical empirical schemes. Settin...

P Depuydt, D Benoit, D Vogelaers, J Decruyenaere, D Vandijck, G Claeys, G Verschraegen, S Blot (2008) INTENSIVE CARE MEDICINE 34: 35 675-682

Daily cost of antimicrobial therapy in patients with Intensive Care Unit-acquired, laboratory-confirmed bloodstream infection

2010-02-08T14:03:39Z

This study analysed daily antimicrobial costs of Intensive Care Unit (ICU)-acquired, laboratory-confirmed bloodstream infection (BSI) per patient admitted to the ICU of a university hospital, based on prospectively collected data over a 4-year period (2003-2006). Costs were calculated based on the price of the agent(s) initiated on the first day of appropriate treatment and according to: (i) focus...

D M Vandijck, M Depaemelaere, S O Labeau, P O Depuydt, L Annemans, F M Buyle, S Oeyen, K E Colpaert, R P Peeman, S I Blot, J A Decruyenaere (2008) INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 31: 13 161-165

Polyurethane cuffed endotracheal tubes to prevent early postoperative pneumonia after cardiac surgery : A pilot study

2010-02-08T14:03:39Z

Objective: Patients receiving mechanical ventilation through an endotracheal tube are at increased risk for pneumonia. Because microaspiration of contaminated supraglottic secretions past the endotracheal tube cuff is considered to be central in the pathogenesis of ventilator-associated and postoperative pneumonia, better sealing of the upper trachea by the endotracheal tube cuff could possibly re...

J Poelaert, P Depuydt, A De Wolf, S V de Velde, I Herck, S Blot (2008) JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 135: 35 771-776

Obstacles to implementing evidence-based guidelines

2010-02-08T14:03:39Z

S O Labeau, D M Vandijck, K H Vandewoude, S I Blot (2008) RESPIRATORY CARE 53: 9 505-506

Education reduces ventilator-associated pneumonia rates

2010-02-08T14:03:39Z

S O Labeau, D M Vandijck, K H Vandewoude, S I Blot (2008) CLINICAL INFECTIOUS DISEASES 46: 8 479-479

Delayed oxygenation assessment in patients with severe community-acquired pneumonia - Reply

2010-02-08T14:03:39Z

S I Blot, A Rodriguez, J Rello (2008) CRITICAL CARE MEDICINE 36: 7 1694-1695

Predictive value of surveillance cultures and subsequent bacteremia with extended-spectrum beta-lactamase-producing Enterobacteriaceae

2010-02-08T14:03:39Z

S Blot, P Depuydt, D Vandijck, K Vandewoude, R Peleman, D Vogelaers (2008) CLINICAL INFECTIOUS DISEASES 46: 10 481-482

Trends in mortality in coronary artery bypass graft patients with acute renal failure

2010-02-08T14:03:39Z

S I Blot, D M Vandijck, E A Hoste (2008) CRITICAL CARE MEDICINE 36: 5 656-656

Facilitating clinician adherence to guidelines in the intensive cafe unit

2010-02-08T14:03:39Z

D M Vandijck, S O Labeau, S I Blot (2008) CRITICAL CARE MEDICINE 36: 6 655-655

Undergraduate nursing students' knowledge and perception of infection prevention and control

2010-02-08T14:03:39Z

D M Vandijck, S O Labeau, J De Somere, B Claes, S I Blot (2008) JOURNAL OF HOSPITAL INFECTION 68: 8 92-94

Implementation of guidelines for the prevention of ventilator-associated pneumonia

2010-02-08T14:03:39Z

S Blot, S Labeau, D Vandijck (2008) AMERICAN SURGEON 74: 9 183-184

Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies

2010-02-08T14:03:39Z

Objective: To compare the characteristics and outcome of patients with hematological malignancies referred to the ICU with severe sepsis and septic shock who had or had not received recent intravenous chemotherapy, defined as within 3 weeks prior to ICU admission. Design and setting: Retrospective observational cohort study on prospectively collected data in a medical ICU of a university hospital....

D M Vandijck, D D Benoit, P O Depuydt, F C Offner, S I Blot, A K Van Tilborgh, J Nollet, E Steel, L A Noens, J M Decruyenaere (2008) INTENSIVE CARE MEDICINE 34: 42 847-855

Critical Care Nurses' Knowledge of Evidence-Based Guidelines for Preventing Infections Associated With Central Venous Catheters : An Evaluation Questionnaire

2010-02-08T14:03:39Z

Background Lack of adherence to recommended evidence-based guidelines for preventing infections associated with use of central venous catheters may be due to nurses' lack of knowledge of the guidelines. Objective To develop a reliable and valid questionnaire for evaluating critical care nurses' knowledge of evidence-based guidelines for preventing infections associated with central venous catheter...

S Labeau, A Vereecke, D M Vandijck, B Claes, S I Blot (2008) AMERICAN JOURNAL OF CRITICAL CARE 17: 28 65-71

Candidemia in critically ill patient : An analysis of daily antifungal therapy related costs

2010-02-08T14:03:39Z

Data on the cost of antifungal therapy in critically ill. patients with candidemia are Lacking. Therefore, a historical observational cohort study was conducted to evaluate the daily cost of antifungal treatment in the critically ill with a microbiologically documented nosocomial candidemia. Over a four-year period (2003-2006), costs were calculated according to the causative pathogen, the source ...

D Vandijck, S Blot, S Labeau, F Buyle, M Depaemelaere, K Vandewoude, J Decruyenaere (2008) JOURNAL DE MYCOLOGIE MEDICALE 18: 17 96-99

The value of procalcitonin to diagnose infection in critically ill patient : caveat emptor!

2010-02-08T14:03:39Z

J J De Waele, E Hoste, S Blot, D Vogelaers (2008) CRITICAL CARE MEDICINE 36: 6 3121-3121

Fluconazole Exposure and Selection for Candida Non-albicans

2010-02-08T14:03:39Z

D M Vandijck, S I Blot, L Vandekerckhove, D P Vogelaers (2008) ANESTHESIA AND ANALGESIA 107: 5 2091-2091

Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia

2010-02-08T14:03:39Z

Introduction The idea that multidrug resistance (MDR) to antibiotics in pathogens causing ventilator-associated pneumonia (VAP) is an independent risk factor for adverse outcome is still debated. We aimed to identify the determinants of MDR versus non-MDR microbial aetiology in VAP and assessed whether MDR versus non-MDR VAP was independently associated with increased 30-day mortality. Methods We ...

P O Depuydt, D M Vandijck, M A Bekaert, J M Decruyenaere, S I Blot, D P Vogelaers, D D Benoit (2008) CRITICAL CARE 12: 44 -

Maximizing rates of empiric appropriate antibiotic therapy with minimized use of broad-spectrum agents : are surveillance cultures the key?

2010-02-08T14:03:39Z

S Blot, P Depuydt, D Vogelaers (2008) INTENSIVE CARE MEDICINE 34: 16 2130-2133

Risk factors for Candida non-albicans candidemia

2010-02-08T14:03:39Z

S Blot, D Vandijck, K Vandewoude (2008) DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 61: 9 362-363

Evidence-based guidelines for the prevention of ventilator-associated pneumonia : results of a knowledge test among European intensive care nurses

2010-02-08T14:03:39Z

As part of a needs analysis preceding the development of an e-learning platform on infection prevention, European intensive care unit (ICU) nurses were subjected to a knowledge test on evidence-based guidelines for preventing ventilator-associated pneumonia (VAP). A validated multiple-choice questionnaire was distributed to 22 European countries between October 2006 and March 2007. Demographics in...

S Labeau, D Vandijck, J Rello, S Adam, A Rosa, C Wenisch, C Backman, K Agbaht, A Csomos, M Seha, G Dimopoulos, K H Vandewoude, S Blot (2008) JOURNAL OF HOSPITAL INFECTION 70: 16 180-185

Abacavir hypersensitivity

2010-02-08T14:03:39Z

L Vandekerckhove, S Blot, D Vogelaers (2008) NEW ENGLAND JOURNAL OF MEDICINE 358: 2 2514-2515

Discriminating invasive fungal infection from colonization

2010-02-08T14:03:39Z

S Blot, K Vandewoude, D Vogelaers (2008) CRITICAL CARE 12: 0 -

Bacteremia in patients with febrile neutropenia following chemotherapy

2010-02-08T14:03:39Z

D M Vandijck, P O Depuydt, S I Blot, J M Decruyenaere (2008) INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 12: 11 449-449

Improving the adequacy of empirical beta-lactam therapy for Pseudomonas aeruginosa ventilator-associated pneumonia

2010-02-08T14:03:39Z

P Depuydt, S Blot, D Benoit, J Decruyenaere (2008) INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 31: 7 489-490

Prediction of morbidity and mortality on admission to a burn unit

2010-02-08T14:07:23Z

N Brusselaers, S J Monstrey, D M Vandijck, S I Blot (2007) PLASTIC AND RECONSTRUCTIVE SURGERY 120: 5 360-361

Evidence-based guidelines for the prevention of ventilator-associated pneumonia : results of a knowledge test among intensive care nurses

2010-02-08T14:07:23Z

Objective: To determine intensive care nurses' knowledge of evidence-based guidelines for the prevention of ventilator-associated pneumonia (VAP). Design: A survey using a validated multiple-choice questionnaire, developed to evaluate nurses' knowledge of VAP prevention. The questionnaire was distributed and collected during the annual congress of the Flemish Society for Critical Care Nurses (Ghen...

S I Blot, S Labeau, D Vandijck, P Van Aken, B Claes (2007) INTENSIVE CARE MEDICINE 33: 20 1463-1467

Recurrent catheter-related bloodstream infections : risk factors and outcome

2010-02-08T14:07:23Z

D M Vandijck, S I Blot (2007) INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 11: 10 371-372

Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality : A study comparing bacteremic vs. nonbacteremic ventilator-associated pneumonia

2010-02-08T14:07:23Z

Objective: To assess whether bacteremic ventilator-associated pneumonia (B-VAP) differs in terms of risk factors, organisms, and outcomes from nonbacteremic VAP (NB-VAP). Design: A retrospective, single-center, observational, cohort study. Setting: Multidisciplinary teaching intensive care unit. Patients: Adult patients requiring mechanical ventilation, identified as having VAP in a 44-month prosp...

K Agbaht, E Diaz, E Munoz, T Lisboa, F Gomez, P Depuydt, S Blot, J Rello (2007) CRITICAL CARE MEDICINE 35: 39 2064-2070

Septicemia as a cause of death in burns

2010-02-08T14:07:23Z

D M Vandijck, N Brusselaers, S I Blot (2007) BURNS 33: 7 538-539

Antibiotic therapy for community-acquired pneumonia with septic shock : Follow the guidelines

2010-02-08T14:07:23Z

S Blot, P Depuydt (2007) CRITICAL CARE MEDICINE 35: 14 1617-1618

Health implications of antimicrobial resistance for patients with acute kidney injury and bloodstream infection

2010-02-08T14:07:23Z

Studies have produced conflicting findings on outcomes for patients with antimicrobial-resistant infection. This study evaluated whether infection with an antimicrobial-resistant organism affects outcome in critically ill patients with acute kidney injury treated with renal replacement therapy and whose clinical course is complicated with a nosocomial bloodstream infection. We found that infection...

E A J Hoste, D M Vandijck, R C Vanholder, J J De Waele, N H Lameire, S Claus, J De Schuijmer, A W Dhondt, J M A Decruyenaere, G Verschraegen, S I Blot (2007) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 28: 11 1107-1110

The value of IL-6 in predicting the severity of acute pancreatitis

2010-02-08T14:07:23Z

J J De Waele, S Blot (2007) JOURNAL OF CLINICAL GASTROENTEROLOGY 41: 3 534-534

Oral care practices in intensive care units : a survey of 59 European ICUs

2010-02-08T14:07:23Z

Objective: To explore the type and frequency of oral care practices in European ICUs and the attitudes, beliefs, and knowledge of health care workers. Design: An anonymous questionnaire was distributed to representatives of European ICUs. Results were obtained from 59 ICUs (one questionnaire per ICU) in seven countries 91% of respondents were registered nurses. Measurements and results: Of the res...

J Rello, D Koulenti, S Blot, R Sierra, E Diaz, J J De Waele, A Macor, K Agbaht, A Rodriguez (2007) INTENSIVE CARE MEDICINE 33: 26 1066-1070

Invasive devices : no need? No use!

2010-02-08T14:07:23Z

S I Blot, R Peleman, K H Vandewoude (2007) INTENSIVE CARE MEDICINE 33: 30 209-211

Comment on : Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia

2010-02-08T14:03:39Z

S Blot, D Vandijck, K Vandewoude, P Depuydt, D Vogelaers, R Peleman (2007) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 60: 10 1402-1402

Antibiotic therapy for ventilator-associated pneumonia : De-escalation in the real world

2010-02-08T14:07:23Z

P Depuydt, S Blot (2007) CRITICAL CARE MEDICINE 35: 15 632-633

Antimicrobial resistance among clinical isolates of Pseudomonas aeruginosa from patients in a teaching hospital

2010-02-08T14:03:39Z

D M Vandijck, S I Blot, J M Decruyenaere (2007) JAPANESE JOURNAL OF INFECTIOUS DISEASES 60: 5 416-416

Adherence to and efficacy and safety of an insulin protocol in the critically ill : A prospective observational study

2010-02-08T14:03:39Z

Background Blood glucose control during acute illness has been associated with improved-outcomes. Objectives To evaluate adherence to and efficacy and safety of an insulin protocol for critically ill patients with target blood glucose levels between 81 and 110 mg/dL and to determine factors associated with adequate daily blood glucose control. Methods In a prospective observational study, blood gl...

S G Oeyen, E A Hoste, C D Roosens, J M Decruyenaere, S I Blot (2007) AMERICAN JOURNAL OF CRITICAL CARE 16: 42 599-608

Critical care nurses' knowledge of evidence-based guideliness for preventing ventilator-associated pneumonia : An evaluation questionnaire

2010-02-08T14:03:39Z

Background Nurses' lack of knowledge may be a barrier to adherence to evidence-based guidelines for preventing ventilator-associated pneumonia. Objective To develop a reliable and valid questionnaire for evaluating critical care nurses' knowledge of evidence-based guidelines for preventing ventilator-associated pneumonia. Methods Ten nursing-related interventions were identified from a review of e...

S Labeau, D M Vandijck, B Claes, P Van Aken, S I Blot (2007) AMERICAN JOURNAL OF CRITICAL CARE 16: 33 371-377

Oral care practices in critical care unit

2010-02-08T14:03:39Z

J Rello, S Blot, A Rodriguez (2007) INTENSIVE CARE MEDICINE 33: 5 2228-2228

Effects of delayed oxygenation assessment on time to antibiotic delivery and mortality in patients with severe community-acquired pneumonia

2010-02-08T14:03:39Z

Background. Practice guidelines suggest processes of care such as timely oxygenation assessment and antibiotic therapy as quality indicators for the management of community-acquired pneumonia. The objective of this study was to determine whether postponed oxygenation assessment (either by pulse oximetry monitoring or arterial blood gas analysis) delays initiation of antibiotic therapy and adversel...

S I Blot, A Rodriguez, J Sole-Violan, J Blanquer, J Almirall, J Rello (2007) CRITICAL CARE MEDICINE 35: 38 2509-2514

Inflammatory markers in patients with severe burn injury : What is the best indicator of sepsis?

2010-02-08T14:07:23Z

D M Vandijck, N Brusselaers, S I Blot (2007) BURNS 33: 12 939-940

Epidemiology, risk factors, and outcomes of Candida albicans versus non-albicans candidemia in nonneutropenic patients

2010-02-08T14:07:23Z

D M Vandijck, S Blot, J Decruyenaere (2007) ANNALS OF PHARMACOTHERAPY 41: 6 1916-1917

Dynamics of C-reactive protein and white blood cell count in critically ill patients with nosocomial Gram positive vs. Gram negative bacteremia : a historical cohort study

2010-02-08T14:07:23Z

Background: Nosocomial bacteremia is associated with a poor prognosis. Early adequate therapy has been shown to improve outcome. Consequently, rapid detection of a beginning sepsis is therefore of the utmost importance. This historical cohort study was designed to evaluate if different patterns can be observed in either C-reactive protein (CRP) and white blood cell count (WCC) between Gram positiv...

D M Vandijck, E A Hoste, S I Blot, P O Depuydt, R A Peleman, J M Decruyenaere (2007) BMC INFECTIOUS DISEASES 7: 27 -

Community-acquired versus nosocomial Klebsiella pneumonia bacteremia : Clinical features, treatment outcomes, and clinical implication of antimicrobial resistance

2010-02-08T14:07:23Z

D M Vandijck, J M Decruyenaere, P Depuydt, S I Blot (2007) JOURNAL OF KOREAN MEDICAL SCIENCE 22: 9 770-771

Microbiologically documented nosocomial infections after coronary artery bypass surgery without cardiopulmonary bypass

2010-02-08T14:07:23Z

D M Vandijck, S I Blot, J I Poelaert (2007) JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 133: 5 590-591

Reduction of blood culture contamination rate by an educational intervention

2010-02-08T14:07:23Z

D M Vandijck, S I Blot, J M Decruyenaere (2007) CLINICAL MICROBIOLOGY AND INFECTION 13: 0 109-109

Antibiotic use and delayed source control in acute appendicitis

2010-02-08T14:07:23Z

J J De Waele, S Blot (2007) ARCHIVES OF SURGERY 142: 6 99-100

Usefulness of blood cultures in the management of febrile patients in long-term care facilities

2010-02-08T14:07:23Z

D M Vandijck, J M Decruyenaere, S I Blot (2006) EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 25: 5 279-279

Hospital consumption of antibiotics in 15 European countries : results of the ESAC retrospective data collection (1997-2002)

2010-02-08T14:07:23Z

Objectives: To collect reliable, comparable and publicly available data on hospital use of antibiotics in Europe aggregated at the national level (1997-2002). Methods: Consumption data of systemic antibiotics in Anatomical Therapeutic Chemical (ATC) class J01 were collected and expressed in defined daily doses (DDD) per 1000 inhabitants per day. Valid data for 2002 were available for 15 countries,...

R H VanderStichele, M M Elseviers, M Ferech, S Blot, H Goossens (2006) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 58: 39 159-167

Effects of selection of control subjects in a case-control study on the outcome of catheter-related bloodstream infection - Reply to Rijnders

2010-02-08T14:07:23Z

S Blot, P Depuydt, K Vandewoude (2006) CLINICAL INFECTIOUS DISEASES 42: 1 1057-1057

Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit

2010-02-08T14:15:41Z

Objective: To study the occurrence of multiple-drug-resistant pathogens in nosocomial bloodstream infection associated with pneumonia. To evaluate prediction of multiple drug resistance by systematic surveillance cultures. Design: A retrospective study of a prospectively gathered cohort. Setting: Fifty-four-bed adult medical-surgical intensive care unit of a tertiary hospital. Patients: One hundre...

P O Depuydt, S I Blot, D D Benoit, G W Claeys, G L Verschraegen, K H Vandewoude, D P Vogelaers, J M Decruyenaere, F A Colardyn (2006) CRITICAL CARE MEDICINE 34: 48 653-659

Saline volume in transvesical intra-abdominal pressure measurement : enough is enough

2010-02-08T14:15:41Z

Objective: The objective was to determine the minimum volume of instillation fluid for intra-abdominal pressure (IAP) measurement, and to evaluate the effect of instillation volume on transvesically measured IAP. Design: Prospective cohort study Setting: Twenty-two-bed surgical ICU of the Ghent University Hospital Patients and participants: Twenty patients at risk of intra-abdominal hypertension (...

J De Waele, P Pletinckx, S Blot, E Hoste (2006) INTENSIVE CARE MEDICINE 32: 14 455-459

Effect of fluconazole consumption on long-term trends in candidal ecology

2010-02-08T14:07:23Z

Background: Fluconazole is an antifungal agent that is widely used for the treatment of Candida infection. Because of its favourable safety profile it is extensively used for prophylaxis in patient populations with a substantial risk for Candida infection. At the individual patient level, exposure to fluconazole selects for Candida non-albicans strains such as Candida glabrata and Candida krusei, ...

S Blot, R Janssens, G Claeys, E Hoste, F Buyle, J J De Waele, R Peleman, D Vogelaers, K Vandewoude (2006) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 58: 10 474-477

Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit

2010-02-08T14:07:23Z

Colonization by antibiotic-resistant gram-negative bacteria and appropriate empirical antibiotic therapy in intensive care unit patients - Reply to Bellissimo-Rodrigues et al.

2010-02-08T14:07:23Z

S Blot (2006) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 27: 6 105-105

Nosocomial pneumonia : aetiology, diagnosis and treatment

2010-02-08T14:07:23Z

Purpose of review This review highlights recent advances in the aetiology of nosocomial pneumonia, and in strategies to increase accuracy of diagnosis and antibiotic prescription while limiting unnecessary antibiotic consumption. Recent findings Bacterial pathogens still cause the bulk of nosocomial pneumonia and are of concern because of ever-rising antimicrobial resistance. Yet, the pathogenic r...

P Depuydt, D Myny, S Blot (2006) CURRENT OPINION IN PULMONARY MEDICINE 12: 70 192-197

Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients

2010-02-08T14:07:23Z

Introduction The diagnosis of invasive pulmonary aspergillosis, according to the criteria as defined by the European Organisation for the Research and Treatment of Cancer/ Mycoses Study Group (EORTC/MSG), is difficult to establish in critically ill patients. The aim of this study is to address the clinical significance of isolation of Aspergillus spp. from lower respiratory tract samples in critic...

K H Vandewoude, S I Blot, P Depuydt, D Benoit, W Temmerman, F Colardyn, D Vogelaers (2006) CRITICAL CARE 10: 46 -

The value of sepsis definitions in daily ICU-practice

2010-02-08T14:07:23Z

Sepsis is a major disease entity with important clinical and economic implications. Sepsis is the hosts' reaction to infection and is characterized by a systemic inflammatory response. Because of difficulties in defining sepsis, the SIRS was introduced trying to summarize the inflammatory response in a limited set of elementary characteristics (fever or hypothermia, leucocytosis or leucopenia, tac...

D M Vandijck, J M Decruyenaere, S I Blot (2006) ACTA CLINICA BELGICA 61: 47 220-226

Invasive aspergillosis in immunocompetent patients

2010-02-08T14:07:23Z

S I Blot, K H Vandewoude (2006) SOUTHERN MEDICAL JOURNAL 99: 7 1398-1398

Outcome in bacteremia associated with nosocomial pneumonia and the impact of pathogen prediction by tracheal surveillance cultures

2010-02-08T14:07:23Z

Objective: To assess whether pathogen prediction in bacteremia associated with nosocomial pneumonia (NP) by tracheal surveillance cultures improves adequacy of early antibiotic therapy and impacts mortality. Design and setting: A retrospective observational study of a prospectively gathered cohort. This cohort included all adult patients admitted to the ICU of a tertiary care hospital from 1992 th...

P Depuydt, D Benoit, D Vogelaers, G Claeys, G Verschraegen, K Vandewoude, J Decruyenaere, S Blot (2006) INTENSIVE CARE MEDICINE 32: 48 1773-1781

Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa

2010-02-08T14:07:23Z

D M Vandijck, J M Decruyenaere, S I Blot (2006) JOURNAL OF INFECTION 53: 5 289-289

Critical issues in the clinical management of complicated intra-abdominal infections

2010-02-08T14:15:41Z

Intra-abdominal infections differ from other infections through the broad variety in causes and severity of the infection, the aetiology of which is often polymicrobial, the microbiological results that are difficult to interpret and the essential role of surgical intervention. From a clinical viewpoint, two major types of intra-abdominal infections can be distinguished: uncomplicated and complica...

S Blot, J J De Waele (2005) DRUGS 65: 55 1611-1620

Fluid vs. air for semicontinuous intra-abdominal pressure measurements using a compliance catheter

2010-02-08T14:15:41Z

J De Waele, E A I Billiet, E Hoste, S I Blot, F A Colardyn (2005) INTENSIVE CARE MEDICINE 31: 4 598-599

Sodium bicarbonate versus THAM in ICU patients with mild metabolic acidosis

2010-02-08T14:15:41Z

Background: Sodium bicarbonate is despite its side effects, considered the standard alkali therapy in metabolic acidosis. THAM is an alternative alkalizing agent; however, there are limited data on the use of THAM in metabolic acidosis. The aim of this study was to compare the efficacy and adverse effects of a single dose of sodium bicarbonate and THAM in intensive care unit (ICU) patients with mi...

E A Hoste, K Colpaert, R C Vanholder, N H Lameire, J J De Waele, S I Blot, F A Colardyn (2005) JOURNAL OF NEPHROLOGY 18: 17 303-307

Documented and clinically suspected bacterial infection precipitating intensive care unit admission in patients with hematological malignancies : impact on outcome

2010-02-08T14:15:41Z

Objective: To assess the impact of documented and clinically suspected bacterial infection precipitating ICU admission on in-hospital mortality in patients with hematological malignancies. Design and setting: Prospective observational study in a 14-bed medical ICU at a tertiary university hospital. Patients: A total of 172 consecutive patients with hematological malignancies admitted to the ICU fo...

D D Benoit, P O Depuydt, R A Peleman, F C Offner, K H Vandewoude, D P Vogelaers, S I Blot, L A Noens, F A Colardyn, J M Decruyenaere (2005) INTENSIVE CARE MEDICINE 31: 38 934-942

Influence of matching for exposure time on estimates of attributable mortality caused by nosocomial bacteremia in critically ill patients

2010-02-08T14:15:41Z

OBJECTIVE: To evaluate the influence of matching on exposure time on estimates of attributable mortality of nosocomial bacteremia as assessed by matched cohort studies. DESIGN: Two retrospective, pairwise-matched (1:2) cohort studies. SETTING: A 54-bed intensive care unit (ICU) in a university hospital. PATIENTS: Patients with nosocomial Escherichia coli bacteremia (n = 68) and control-patients wi...

S Blot, D De Bacquer, E Hoste, P Depuydt, K Vandewoude, J De Waele, D Benoit, J De Schuijmer, F Colardyn, D Vogelaers (2005) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 26: 27 352-356

Ventilator-associated pneumonia in a tertiary care ICU : Analysis of risk factors for acquisition and mortality

2010-02-08T14:15:41Z

Objective: To investigate the incidence, risk factors and mortality of ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients. Design: Prospective, observational, population-based study. Setting: The medical (14-bed) and surgical ICU (26-bed) of the Ghent University Hospital. Methods: All 1295 patients admitted to the ICU during 4 three-month periods between 1996 and 1998 were...

D Myny, P Depuydt, F Colardyn, S Blot (2005) ACTA CLINICA BELGICA 60: 29 114-121

Intra-abdominal hypertension in patients with severe acute pancreatitis

2010-02-08T14:15:41Z

Introduction Abdominal compartment syndrome has been described in patients with severe acute pancreatitis, but its clinical impact remains unclear. We therefore studied patient factors associated with the development of intra-abdominal hypertension (IAH), the incidence of organ failure associated with IAH, and the effect on outcome in patients with severe acute pancreatitis ( SAP). Methods We stud...

J J De Waele, E Hoste, S I Blot, J Decruyenaere, F Colardyn (2005) CRITICAL CARE 9: 23 R452-R457

Temporal scanner thermometry : A new method of core temperature estimation in ICU patients

2010-02-08T14:15:41Z

Background and Aims: Temperature measurement is a routine task of patient care, with considerable clinical impact, especially in the ICU. This study was conducted to evaluate the accuracy and variability of the Temporal Artety Thermometer (TAT) in ICU-patients. Therefore, a convenience sample Of 57 adult patients, with indwelling pulmonary artery catheters (PAC) in a 40-bed intensive care unit in ...

D Myny, J De Made, T Defloor, S Blot, F Colardyn (2005) SCOTTISH MEDICAL JOURNAL 50: 10 15-18

Colonization status and appropriate antibiotic therapy for nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in an intensive care unit

2010-02-08T14:15:41Z

OBJECTIVE: Timely initiation of antibiotic therapy is crucial for severe infection. Appropriate antibiotic therapy is often delayed for nosocomial infections caused by antibiotic-resistant bacteria. The relationship between knowledge of colonization caused by antibiotic-resistant gram-negative bacteria (ABR-GNB) and rate of appropriate initial antibiotic therapy for subsequent bacteremia was evalu...

S Blot, P Depuydt, D Vogelaers, J Decruyenaere, J De Waele, E Hoste, R Peleman, G Claeys, G Verschraegen, F Colardyn, K Vandewoude (2005) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 26: 27 575-579

Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections

2010-02-08T14:15:41Z

Background. Central venous catheters are universally used during the treatment of critically ill patients. Their use, however, is associated with a substantial infection risk, potentially leading to increased mortality and costs. We evaluate clinical and economic outcomes associated with nosocomial central venous catheter - related bloodstream infection (CR- BSI) in intensive care unit (ICU) patie...

S I Blot, P Depuydt, L Annemans, D Benoit, E Hoste, J J de Waele, J Decruyenaere, D Vogelaers, F Colardyn, K H Vandewoude (2005) CLINICAL INFECTIOUS DISEASES 41: 39 1591-1598

Outcome and changes over time in survival following severe burns from 1985 to 2004

2010-02-08T14:15:41Z

Objective: To investigate outcome in severely burned patients over a 20-year period and to evaluate survival over time. Historical cohort in a six-bed burn unit of a 1060-bed university hospital. Paitents: 1385 patients admitted to the burn unit over a 20-year period. Measurements and results: Outcome was evaluated in relation to the presence of three major risk factors for death: age 60 years or ...

N Brusselaers, E A J Hoste, S Monstrey, K E Colpaert, J J De Waele, K H Vandewoude, S I Blot (2005) INTENSIVE CARE MEDICINE 31: 31 1648-1653

Sodium bicarbonate versus THAM in ICU patients with mild metabolic acidosis

2010-02-08T14:07:23Z

Subclinical iron deficiency is a strong predictor of bacterial vaginosis in early pregnancy

2010-02-08T14:07:23Z

Background: Bacterial vaginosis (BV) is the single most common vaginal infection in women of childbearing age and associated with a sizeable infectious disease burden among both non-pregnant and pregnant women, including a significantly elevated risk of adverse pregnancy outcome. Overall, little progress has been made in identifying causal factors involved in BV acquisition and persistence. We sou...

H Verstraelen, J Delanghe, K Roelens, S Blot, G Claeys, M Temmerman (2005) BMC INFECTIOUS DISEASES 5: 45 -

Critical issues in the clinical management of complicated intra-abdominal infections

2010-02-08T14:07:23Z

Subclinical iron deficiency is a strong predictor of bacterial vaginosis in early pregnancy

2010-02-08T14:15:41Z

Intra-abdominal hypertension in patients with severe acute pancreatitis

2010-02-08T14:07:23Z

Ventilator-associated pneumonia in a tertiary care ICU : Analysis of risk factors for acquisition and mortality

2010-02-08T14:07:23Z

MRSA pneumonia : Better outcome through continuous infusion of vancomycin?

2010-02-08T14:07:23Z

S Blot (2005) CRITICAL CARE MEDICINE 33: 15 2127-2128

Outcome and changes over time in survival following severe burns from 1985 to 2004

2010-02-08T14:07:23Z

Documented and clinically suspected bacterial infection precipitating intensive care unit admission in patients with hematological malignancies : impact on outcome

2010-02-08T14:07:23Z

Influence of matching for exposure time on estimates of attributable mortality caused by nosocomial bacteremia in critically ill patients

2010-02-08T14:07:23Z

Temporal scanner thermometry : A new method of core temperature estimation in ICU patients

2010-02-08T14:07:23Z

Fluid vs. air for semicontinuous intra-abdominal pressure measurements using a compliance catheter

2010-02-08T14:07:23Z

J De Waele, E A I Billiet, E Hoste, S I Blot, F A Colardyn (2005) INTENSIVE CARE MEDICINE 31: 4 598-599

Invasive aspergillosis in critically ill patients : Analysis of risk factors for acquisition and mortality

2010-02-08T14:15:41Z

Objective: To investigate outcome in patients who develop invasive aspergillosis in the ICU, and to evaluate whether specific risk factors for the acquisition of invasive aspergillosis are associated with mortality. Design: Retrospective cohort study (07/1997-12/1999) with screening of 8988 admissions. Setting: 54-bed ICU of the 1060-bed Ghent University Hospital. Patients: 38 ICU patients with in...

K Vandewoude, S Blot, D Benoit, P Depuydt, D Vogelaers, F Colardyn (2004) ACTA CLINICA BELGICA 59: 24 251-257

Perioperative factors determine outcome after surgery for severe acute pancreatitis

2010-02-08T14:15:41Z

Introduction There is evidence that postponing surgery in critically ill patients with severe acute pancreatitis ( SAP) leads to improved survival, but previous reports included patients with both sterile and infected pancreatic necrosis who were operated on for various indications and with different degrees of organ dysfunction at the moment of surgery, which might be an important bias. The objec...

J J De Waele, E Hoste, S I Blot, U Hesse, P Pattyn, B de Hemptinne, J Decruyenaere, D Vogelaers, F Colardyn (2004) CRITICAL CARE 8: 27 R504-R511

Bloodstream infections after surgery for severe acute pancreatitis

2010-02-08T14:15:41Z

Objective: To analyze the incidence and outcome of bloodstream infections (BSIs) in patients operated on for severe acute pancreatitis to identify the source and associated risk factors. Methods: We retrospectively ( 1995 - 2001) analyzed 45 patients treated surgically for severe acute pancreatitis. We recorded demographic characteristics, data on surgical and medical treatment and disease severit...

J De Waele, S Blot, F Colardyn (2004) PANCREAS 28: 14 391-394

Emergence of antibiotic resistance in infected pancreatic necrosis

2010-02-08T14:15:41Z

Background: Overall, the use of antibiotics in the treatment of patients with severe acute pancreatitis has increased owing to the use of antibiotic prophylaxis. Hypothesis: The incidence of antibiotic-resistant (AB-R) bacteria in infected pancreatitis is related to prolonged antibiotic treatment and may affect outcome. Design: Case series. Setting: Fifty-six-bed intensive care unit of a tertiary ...

J J De Waele, D Vogelaers, E Hoste, S Blot, F Colardyn (2004) ARCHIVES OF SURGERY 139: 34 1371-1375

Early detection of systemic infections

2010-02-08T14:15:41Z

S Blot, K Vandewoude (2004) ACTA CLINICA BELGICA 59: 42 20-23

European Surveillance of Antimicrobial Consumption (ESAC) : Data collection performance and methodological approach

2010-02-08T14:07:23Z

Background Europe is a continent with strong public healthcare systems, but diverging antibiotic policies and resistance patterns. Aims To describe the performance and methodological approach in a retrospective data collection effort (1997-2001), through an international network of surveillance systems, aiming to collect publicly available, comparable and reliable data on antibiotic use in Europe....

R H Vander Stichele, M M Elseviers, M Ferech, S Blot, H Goossens (2004) BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 58: 19 419-428

European Surveillance of Antimicrobial Consumption (ESAC) : Data collection performance and methodological approach

2010-02-08T14:15:41Z

High infection rates in patients with severe acute necrotizing pancreatitis

2010-02-08T14:07:23Z

J J De Waele, S I Blot, D Vogelaers, F Colardyn (2004) INTENSIVE CARE MEDICINE 30: 6 1248-1248

Management of invasive candidiasis in critically ill patients

2010-02-08T14:15:41Z

Candida species have become predominant pathogens in critically ill patients. In this population, invasive candidiasis is associated with a poor prognosis but adequate management can limit the attributable mortality. Adequate management, however, is hampered by a problematic diagnosis as the clinical picture of invasive disease is non-specific and blood cultures have a low sensitivity. Moreover, i...

S Blot, K Vandewoude (2004) DRUGS 64: 132 2159-2175

Early detection of systemic infections

2010-02-08T14:07:23Z

S Blot, K Vandewoude (2004) ACTA CLINICA BELGICA 59: 42 20-23

Invasive aspergillosis in critically ill patients : attributable mortality and excesses in length of ICU stay and ventilator dependence

2010-02-08T14:15:41Z

Invasive aspergillosis is a rare disease in intensive care unit (ICU) patients and carries a poor prognosis. The aim of the present study was to determine the attributable mortality due to invasive aspergillosis in critically ill patients. In a retrospective, matched cohort study (July 1997-December 1999), 37 ICU patients with invasive aspergittosis were identified together with 74 control patient...

K H Vandewoude, S I Blot, D Benoit, F Colardyn, D Vogelaers (2004) JOURNAL OF HOSPITAL INFECTION 56: 32 269-276

Effect of nosocomial bloodstream infection on the outcome of critically ill patients with acute renal failure treated with renal replacement therapy

2010-02-08T14:15:41Z

Critically ill patients with acute renal failure (ARF) treated with renal replacement therapy (RRT) have a high mortality. The authors evaluated a cohort of 704 consecutive intensive care unit (ICU) patients with ARF treated with RRT to determine whether there was an increased incidence of nosocomial bloodstream infection and whether this resulted in a worse outcome. The incidence of nosocomial bl...

E A J Hoste, S I Blot, N H Lameire, R C Vanholder, D De Bacquer, F A Colardyn (2004) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 15: 43 454-462

Invasive aspergillosis in critically ill patients : attributable mortality and excesses in length of ICU stay and ventilator dependence

2010-02-08T14:07:23Z

Evaluation of outcome in critically ill patients with nosocomial Enterobacter bacteremia - Results of a matched cohort study

2010-02-08T14:15:41Z

Study objective: To evaluate the clinical impact of nosocomial Enterobacter bacteremia in critically ill patients. Design: Retrospective (January 1992 to December 2000) matched cohort study. Setting: Fifty-four-bed ICU (including medical, surgical, cardiosurgical ICU, and burns unit) from a university hospital. Patients: Sixty-seven ICU patients with Enterobacter bacteremia (case patients) and 134...

S I Blot, K H Vandewoude, F A Colardyn (2003) CHEST 123: 29 1208-1213

Absence ofexcess moktality in critically ill patients with nosocomial Escherichia coli bacteremia

2010-02-08T14:15:41Z

OBJECTIVE: To evaluate excess mortality in critically ill, patients with Escherichia coli bacteremia after adjustment for severity of illness. DESIGN: Retrospective (1992-2000), pairwise-matched (1:2), risk-adjusted cohort study. SETTING: Fifty-four-bed ICU in a university hospital including a medical and surgical ICU, a unit for care after cardiac surgery, and a burns unit. PATIENTS: ICU patients...

S Blot, K Vandewoude, E Hoste, J De Waele, K Kint, F Rosiers, D Vogelaers, F Colardyn (2003) INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 24: 26 912-915

Fungal infections in patients with severe acute pancreatitis and the use of prophylactic therapy

2010-02-08T14:15:41Z

Data from an 8-year period for 46 patients with severe acute pancreatitis and infected pancreatic necrosis were analyzed to determine the incidence of fungal infection, to identify risk factors for the development of fungal infection, and to assess the use of early fluconazole treatment. Intraabdominal fungal infection was found in 17 (37%) of 46 patients. Candida albicans was isolated most freque...

J J De Waele, D Vogelaers, S Blot, F Colardyn (2003) CLINICAL INFECTIOUS DISEASES 37: 19 208-213

Reappraisal of attributable mortality in critically ill patients with nosocomial bacteraemia involving Pseudomonas aeruginosa

2010-02-08T14:15:41Z

In a retrospective study, population characteristics and outcome were investigated in intensive care unit (ICU) patients with hospital-acquired Pseudomonas aeruginosa bacteraemia admitted over a seven-year period (January 1992 through December 1998). A matched cohort study was performed in which all ICU patients with P. aeruginosa bacteraemia were defined as cases (N = 53). Matching (1:2 ratio) of...

S Blot, K Vandewoude, E Hoste, F Colardyn (2003) JOURNAL OF HOSPITAL INFECTION 53: 28 18-24

Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients : a matched cohort study

2010-02-08T14:07:23Z

Objective: To determine outcome and attributable mortality in critically ill patients with nosocomial bacteremia involving A. baumannii. Design: A retrospective matched cohort study in which all ICU patients with microbiologically documented A. baumannii bacteremia were defined as cases. Matching of the controls was based on equivalent APACHE II score ( 2 points) and diagnostic category. Control p...

S Blot, K Vandewoude, F Colardyn (2003) INTENSIVE CARE MEDICINE 29: 17 471-475

Fungal infections in patients with severe acute pancreatitis and the use of prophylactic therapy

2010-02-08T14:07:23Z

Evaluation of outcome in critically ill patients with nosocomial Enterobacter bacteremia - Results of a matched cohort study

2010-02-08T14:07:23Z

Estimates of attributable mortality of systemic candida infection in the ICU

2010-02-08T14:07:23Z

S I Blot, E A Hoste, K H Vandewoude, F A Colardyn (2003) JOURNAL OF CRITICAL CARE 18: 4 130-131

Estimating attributable mortality of candidemia : Clinical judgement vs. matched cohort studies

2010-02-08T14:07:23Z

S I Blot, K H Vandewoude (2003) EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 22: 6 132-133

Effects of nosocomial candidemia on outcomes of critically ill patients

2010-02-08T14:18:40Z

PURPOSE: To determine whether nosocomial candidemia is associated with increased mortality in intensive care unit (ICU) patients. SUBJECTS AND METHODS: We performed a retrospective (1992 to 2000) cohort study of 73 ICU patients with candidemia and 146 matched controls. Controls were matched based on disease severity as measured by the Acute Physiology and Chronic Health Evaluation (APACHE) II scor...

S I Blot, K H Vandewoude, E A Hoste, F A Colardyn (2002) AMERICAN JOURNAL OF MEDICINE 113: 28 480-485

No early respiratory benefit with CVVHDF in patients with acute renal failure and acute lung injury

2010-02-08T14:15:41Z

Background. There is debate as to whether, in patients with acute lung injury, continuous renal replacement therapy has beneficial effects on pulmonary gas exchange by mechanisms other than fluid removal. Because continuous renal replacement therapy is associated with potential morbidity and mortality, it seems unethical to perform a randomized trial in patients with acute lung injury without rena...

E A J Hoste, R C Vanholder, N H Lameire, C D V K Roosens, J M A Decruyenaere, S I Blot, F A Colardyn (2002) NEPHROLOGY DIALYSIS TRANSPLANTATION 17: 24 2153-2158

Clinical impact of nosocomial Klebsiella bacteremia in critically ill patients

2010-02-08T14:18:40Z

In order to determine the clinical impact of Klebsiella bacteremia on critically ill patients, a matched cohort study was conducted between January 1992 and December 2000. During the study period, all intensive care unit (ICU) patients with nosocomial Klebsiella bacteremia were defined as cases (n=52), but two of these patients were excluded from the matched cohort due to incomplete medical record...

S I Blot, K H Vandewoude, F A Colardyn (2002) EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 21: 15 471-473

Outcome and attributable mortality in critically ill patients with bacteremia involving methicillin-susceptible and methicillin-resistant Staphylococcus aureus

2010-02-08T14:18:40Z

Background: Staphylococcus aureus bacteremia carries high mortality rates. The clinical impact of methicillin resistance remains controversial: outcome comparisons between patients with bacteremia involving methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) S aureus are difficult to perform because of important differences in severity of illness. Methods: A retrospective cohort analys...

S I Blot, K H Vandewoude, E A Hoste, F A Colardyn (2002) ARCHIVES OF INTERNAL MEDICINE 162: 43 2229-2235

Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients : Clinical outcome and length of hospitalization

2010-02-08T14:18:40Z

Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n = 208) or antibiotic-resistant (AB-R; n = 120) gram-negative bacteria. No significant differences in severity of illness and comorbidity factors were seen between groups. Patients with bacteremia caused by AB-R strains had a longer h...

S Blot, K Vandewoude, D De Bacquer, F Colardyn (2002) CLINICAL INFECTIOUS DISEASES 34: 27 1600-1606

Outcome in critically ill patients with candidal fungaemia : Candida albicans vs. Candida glabrata

2010-02-08T14:12:06Z

In a retrospective study (1 January 1992-12 December 1998), we investigated population characteristics and outcome in critically ill patients with fungaemia involving C. albicans (n=41) and C. glabrata (n=15). Patients with C. glabrata fungaemia were significantly older compared with patients in the C. albicans group (P=0.024). There were no other differences in population characteristics or sever...

S Blot, K Vandewoude, E Hoste, J Poelaert, F Colardyn (2001) JOURNAL OF HOSPITAL INFECTION 47: 28 308-313

Prevalence and risk factors for colonisation with Gram-negative bacteria in an intensive care unit

2010-02-08T14:12:06Z

Objective: To investigate prevalence and determine risk factors for colonisation with Cram-negative bacteria in ICU patients. Design: Prospective, surveillance study. Setting: 26-bed surgical and paediatric ICU. Patients: 159 patients - whereof 22 infants - admitted to the surgical/paediatric ICU over a two-month period. Intervention: In all patients routine microbiological monitoring was performe...

S Blot, K Vandewoude, K Blot, F Colardyn (2000) ACTA CLINICA BELGICA 55: 31 249-256