http://publicationslist.org/data/susan.coort/atom.xml Susan Coorthttp://publicationslist.org/susan.coort$basepathfavicon.icoRecent additions to Susan Coort's PublicationsList.org pagehttp://publicationslist.org/publications.png2015-07-27T07:23:26Z http://publicationslist.org/susan.coort/refid36 2015-07-27T07:21:38Z

Nowadays a broad collection of transcriptomics data is publicly available in online repositories. Methods for analyzing these data often aim at deciphering the influence of gene expression at the process level. Biological pathway diagrams depict known processes and capture the interactions of gene products and metabolites, information that is essential for the computational analysis and interpreta...<br/><br/>Martina Kutmon, Chris T Evelo, Susan L Coort (2014) <i>BMC genomics</i> <i></i> <i></i> 15: <br/>

http://publicationslist.org/susan.coort/refid35 2015-07-27T07:21:38Z

There is growing interest in the potential health benefits of diets that involve regular periods of fasting. While animal studies have provided compelling evidence that feeding patterns such as alternate-day fasting can increase longevity and reduce incidence of many chronic diseases, the evidence from human studies is much more limited and equivocal. Additionally, although several candidate proce...<br/><br/>R M Elliott, B de Roos, S J Duthie, F G Bouwman, I Rubio-Aliaga, L K Crosley, C Mayer, A C Polley, C Heim, S L Coort, C T Evelo, F Mulholland, H Daniel, E C Mariman, I T Johnson (2014) <i>Genes & nutrition</i> <i></i> <i></i> 9: 6 <br/>

http://publicationslist.org/susan.coort/refid33 2014-08-26T13:19:20Z

Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from healthy subjects and patients with platelet function deficiencies. A systematic comparison is made of 52 adhesive surfaces with components activat...<br/><br/>Susanne M de Witt, Frauke Swieringa, Rachel Cavill, Moniek M E Lamers, Roger van Kruchten, Tom Mastenbroek, Constance Baaten, Susan Coort, Nicholas Pugh, Ansgar Schulz, Inge Scharrer, Kerstin Jurk, Barbara Zieger, Kenneth J Clemetson, Richard W Farndale, Johan W M Heemskerk, Judith M E M Cosemans (2014) <i>Nature communications</i> <i></i> <i></i> 5: <br/>

http://publicationslist.org/susan.coort/refid34 2015-07-27T07:21:38Z

The high complexity and dynamic nature of the regulation of gene expression, protein synthesis, and protein activity pose a challenge to fully understand the cellular machinery. By deciphering the role of important players, including transcription factors, microRNAs, or small molecules, a better understanding of key regulatory processes can be obtained. Various databases contain information on the...<br/><br/>Martina Kutmon, Thomas Kelder, Pooja Mandaviya, Chris T A Evelo, Susan L Coort (2013) <i>PloS one</i> <i></i> <i></i> 8: 12 <br/>

http://publicationslist.org/susan.coort/refid28 2014-08-26T13:19:21Z

Moderate selenium deficiency may lead to an impaired capacity to cope with health challenges. Functional effects of suboptimal selenium intake are not fully known, and biomarkers for an insufficient selenium supply are inadequate. We therefore fed mice diets of moderately deficient or adequate selenium intake for 6 weeks. Changes in global gene expression were monitored by microarray analysis in s...<br/><br/>Anna P Kipp, Antje Banning, Evert M van Schothorst, Catherine Méplan, Susan L Coort, Chris T Evelo, Jaap Keijer, John Hesketh, Regina Brigelius-Flohé (2012) <i>The Journal of nutritional biochemistry</i> <i></i> <i></i> 23: 9 1170-1177<br/>

http://publicationslist.org/susan.coort/refid32 2014-08-26T13:19:21Z

Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in previously healthy people. The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown.<br/><br/>Maarten F Corsten, Anna Papageorgiou, Wouter Verhesen, Paolo Carai, Morten Lindow, Susanna Obad, Georg Summer, Susan L M Coort, Mark Hazebroek, Rick van Leeuwen, Marion J J Gijbels, Erwin Wijnands, Erik A L Biessen, Menno P J De Winther, Frank R M Stassen, Peter Carmeliet, Sakari Kauppinen, Blanche Schroen, Stephane Heymans (2012) <i>Circulation research</i> <i></i> <i></i> 111: 4 415-425<br/>

http://publicationslist.org/susan.coort/refid20 2014-08-26T13:19:21Z

Proteomic technologies applied for profiling human biofluids and blood cells are considered to reveal new biomarkers of exposure or provide insights into novel mechanisms of adaptation.<br/><br/>Freek G Bouwman, Baukje de Roos, Isabel Rubio-Aliaga, L Katie Crosley, Susan J Duthie, Claus Mayer, Graham Horgan, Abigael C Polley, Carolin Heim, Susan L M Coort, Chris T Evelo, Francis Mulholland, Ian T Johnson, Ruan M Elliott, Hannelore Daniel, Edwin C M Mariman (2011) <i>BMC medical genomics</i> <i></i> <i></i> 4: <br/>

http://publicationslist.org/susan.coort/refid29 2014-08-26T13:19:21Z

Recent studies demonstrate that maternal diet during pregnancy results in long-lasting effects on the progeny. Supplementation of maternal diet with genistein, a phytoestrogen ubiquitous in the daily diet, altered coat color of agouti mice due to epigenetic changes. We studied hematopoiesis of mice prenatally exposed to genistein (270 mg/kg feed) compared with that of mice prenatally exposed to ph...<br/><br/>Kimberly Vanhees, Susan Coort, Erik J B Ruijters, Roger W L Godschalk, Frederik J van Schooten, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani (2011) <i>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</i> <i></i> <i></i> 25: 2 797-807<br/>

http://publicationslist.org/susan.coort/refid21 2014-08-26T13:19:21Z

Obesity frequently leads to insulin resistance and the development of hepatic steatosis. To characterize the molecular changes that promote hepatic steatosis, transcriptomics, proteomics, and metabolomics technologies were applied to liver samples from C57BL/6J mice obtained from two independent intervention trials. After 12 wk of high-fat feeding the animals became obese, hyperglycemic, and insul...<br/><br/>Isabel Rubio-Aliaga, Baukje de Roos, Manuela Sailer, Gerard A McLoughlin, Mark V Boekschoten, Marjan van Erk, Eva-Maria Bachmair, Evert M van Schothorst, Jaap Keijer, Susan L Coort, Chris Evelo, Michael J Gibney, Hannelore Daniel, Michael Muller, Robert Kleemann, Lorraine Brennan (2011) <i>Physiological genomics</i> <i></i> <i></i> 43: 8 408-416<br/>

http://publicationslist.org/susan.coort/refid22 2014-08-26T13:19:21Z

Although CPT-I (carnitine palmitoyltransferase-I) is generally regarded to present a major rate-controlling site in mitochondrial beta-oxidation, it is incompletely understood whether CPT-I is rate-limiting in the overall LCFA (long-chain fatty acid) flux in the heart. Another important site of regulation of the LCFA flux in the heart is trans-sarcolemmal LCFA transport facilitated by CD36 and FAB...<br/><br/>Joost J F P Luiken, Hanneke E C Niessen, Susan L M Coort, Nicole Hoebers, Will A Coumans, Robert W Schwenk, Arend Bonen, Jan F C Glatz (2009) <i>The Biochemical journal</i> <i></i> <i></i> 419: 2 447-455<br/>

http://publicationslist.org/susan.coort/refid30 2014-08-26T13:19:21Z

Selenium is an essential micronutrient. Its recommended daily allowance is not attained by a significant proportion of the population in many countries and its intake has been suggested to affect colorectal carcinogenesis. Therefore, microarrays were used to determine how both selenoprotein and global gene expression patterns in the mouse colon were affected by marginal selenium deficiency compara...<br/><br/>Anna Kipp, Antje Banning, Evert M van Schothorst, Catherine Méplan, Lutz Schomburg, Chris Evelo, Susan Coort, Stan Gaj, Jaap Keijer, John Hesketh, Regina Brigelius-Flohé (2009) <i>Molecular nutrition & food research</i> <i></i> <i></i> 53: 12 1561-1572<br/>

http://publicationslist.org/susan.coort/refid31 2014-08-26T13:19:21Z

Carotenoid metabolism is relevant to the prevention of various diseases. Although the main actors in this metabolic pathway are known, our understanding of the pathway is still incomplete. The information on the carotenoids is scattered in the large and growing body of scientific literature. We designed a text-mining work flow to enrich existing pathways. It has been validated on the vitamin A pat...<br/><br/>Andra Waagmeester, Piotr Pezik, Susan Coort, Franck Tourniaire, Chris Evelo, Dietrich Rebholz-Schuhmann (2009) <i>Omics : a journal of integrative biology</i> <i></i> <i></i> 13: 5 367-379<br/>

http://publicationslist.org/susan.coort/refid19 2011-12-12T14:28:10Z

Biological pathways are a useful abstraction of biological concepts, and software tools to deal with pathway diagrams can help biological research. PathVisio is a new visualization tool for biological pathways that mimics the popular GenMAPP tool with a completely new Java implementation that allows better integration with other open source projects. The GenMAPP MAPP file format is replaced by GPM...<br/><br/>Martijn P van Iersel, Thomas Kelder, Alexander R Pico, Kristina Hanspers, Susan Coort, Bruce R Conklin, Chris Evelo (2008) <i>BMC Bioinformatics</i> <i></i> <i></i> 9: 1 <br/>

http://publicationslist.org/susan.coort/refid1 2008-06-27T17:01:59Z

Contraction-induced glucose uptake is only partly mediated by AMPK activation. We examined whether the diacylglycerol-sensitive protein kinase D (PKD; also known as novel PKC isoform mu) is also involved in the regulation of glucose uptake in the contracting heart. As an experimental model, we used suspensions of cardiac myocytes, which were electrically stimulated to contract or treated with the ...<br/><br/>Joost J F P Luiken, Didier Vertommen, Susan L M Coort, Daphna D J Habets, Mohammed El Hasnaoui, Maurice M L Pelsers, Benoit Viollet, Arend Bonen, Louis Hue, Mark H Rider, Jan F C Glatz (2008) <i>Cell Signal</i> <i></i> <i></i> 20: 3 543-556<br/>

http://publicationslist.org/susan.coort/refid18 2011-07-18T14:17:42Z

Biological pathways are abstract and functional visual representations of existing biological knowledge. By mapping high-throughput data on these representations, changes and patterns in biological systems on the genetic, metabolic and protein level are instantly assessable. Many public domain repositories exist for storing biological pathways, each applying its own conventions and storage format....<br/><br/>Michiel E Adriaens, Magali Jaillard, Andra Waagmeester, Susan L M Coort, Alex R Pico, Chris T A Evelo (2008) <i>Drug Discov Today</i> <i></i> <i></i> 13: 19-20 856-862<br/>

http://publicationslist.org/susan.coort/refid24 2011-07-18T14:17:42Z

Michela Baccini, Eva-Maria Bachmaier, Annibale Biggeri, Mark V Boekschoten, Freek G Bouwman, Lorraine Brennan, Robert Caesar, Saverio Cinti, Susan L Coort, Katie Crosley, Hannelore Daniel, Christian A Drevon, Susan Duthie, Lars Eijssen, Ruan M Elliott, Marjan van Erk, Chris Evelo, Mike Gibney, Carolin Heim, Graham W Horgan, Ian T Johnson, Thomas Kelder, Robert Kleemann, Teake Kooistra, Martijn P van Iersel, Edwin C Mariman, Claus Mayer, Gerard McLoughlin, Michael Müller, Francis Mulholland, Ben van Ommen, Abigael C Polley, Estelle Pujos-Guillot, Isabel Rubio-Aliaga, Helen M Roche, Baukje de Roos, Manuela Sailer, Giulia Tonini, Lynda M Williams, Nicole de Wit (2008) <i>Genes Nutr</i> <i></i> <i></i> 3: 3-4 147-151<br/>

http://publicationslist.org/susan.coort/refid23 2011-07-18T14:17:42Z

Insulin resistance is a characteristic of type-2 diabetes and its development is associated with an increased fat consumption. Muscle is one of the tissues that becomes insulin resistant after high fat (HF) feeding. The aim of the present study is to identify processes involved in the development of HF-induced insulin resistance in muscle of ApOE3*Leiden mice by using microarrays. These mice are k...<br/><br/>Susan L M Coort, Martijn P van Iersel, Marjan van Erk, Teake Kooistra, Robert Kleemann, Chris T A Evelo (2008) <i>Genes Nutr</i> <i></i> <i></i> 3: 3-4 185-191<br/>

http://publicationslist.org/susan.coort/refid3 2008-06-27T17:01:59Z

Cardiovascular disease is the primary cause of death in obesity and type-2 diabetes mellitus (T2DM). Alterations in substrate metabolism are believed to be involved in the development of both cardiac dysfunction and insulin resistance in these conditions. Under physiological circumstances the heart utilizes predominantly long-chain fatty acids (LCFAs) (60-70%), with the remainder covered by carboh...<br/><br/>Susan L M Coort, Arend Bonen, Ger J van der Vusse, Jan F C Glatz, Joost J F P Luiken (2007) <i>Mol Cell Biochem</i> <i></i> <i></i> 299: 1-2 5-18<br/>

http://publicationslist.org/susan.coort/refid2 2008-06-27T17:01:59Z

AIMS/HYPOTHESIS: Changes in cardiac substrate utilisation leading to altered energy metabolism may underlie the development of diabetic cardiomyopathy. We studied cardiomyocyte substrate uptake and utilisation and the role of the fatty acid translocase CD36 in relation to in vivo cardiac function in rats fed a high-fat diet (HFD). METHODS: Rats were exposed to an HFD or a low-fat diet (LFD). In vi...<br/><br/>D M Ouwens, M Diamant, M Fodor, D D J Habets, M M A L Pelsers, M El Hasnaoui, Z C Dang, C E van den Brom, R Vlasblom, A Rietdijk, C Boer, S L M Coort, J F C Glatz, J J F P Luiken (2007) <i>Diabetologia</i> <i></i> <i></i> 50: 9 1938-1948<br/>

http://publicationslist.org/susan.coort/refid4 2008-06-27T17:01:59Z

Recently, fatty acid transport across the plasma membrane has been shown to be a key process that contributes to the regulation of fatty acid metabolism in the heart. Since AMP kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D: -ribofuranoside (AICAR) stimulates fatty acid oxidation, as well as the expression of selected proteins involved with energy provision, we examined (a) whether A...<br/><br/>Adrian Chabowski, Iman Momken, Susan L M Coort, Jorge Calles-Escandon, Narendra N Tandon, Jan F C Glatz, Joost J F P Luiken, Arend Bonen (2006) <i>Mol Cell Biochem</i> <i></i> <i></i> 288: 1-2 201-212<br/>

http://publicationslist.org/susan.coort/refid5 2008-06-27T17:01:59Z

Cellular fatty acid uptake is facilitated by a number of fatty acid transporters, FAT/CD36, FABPpm and FATP1. It had been presumed that FABPpm, was confined to the plasma membrane and was not regulated. Here, we demonstrate for the first time that FABPpm and FATP1 are also present in intracellular depots in cardiac myocytes. While we confirmed previous work that insulin and AICAR each induced the ...<br/><br/>Adrian Chabowski, Susan L M Coort, Jorge Calles-Escandon, Narendra N Tandon, Jan F C Glatz, Joost J F P Luiken, Arend Bonen (2005) <i>FEBS Lett</i> <i></i> <i></i> 579: 11 2428-2432<br/>

http://publicationslist.org/susan.coort/refid6 2008-06-27T17:01:59Z

Thiazolidinediones (TZDs) increase tissue insulin sensitivity in diabetes. Here, we hypothesize that, in adipose tissue, skeletal muscle, and heart, alterations in protein-mediated FA uptake are involved in the effect of TZDs. As a model, we used obese Zucker rats, orally treated for 16 days with 5 mg rosiglitazone (Rgz)/kg body mass/day. In adipose tissue from Rgz-treated rats, FA uptake capacity...<br/><br/>S L M Coort, W A Coumans, A Bonen, G J van der Vusse, J F C Glatz, J J F P Luiken (2005) <i>J Lipid Res</i> <i></i> <i></i> 46: 6 1295-1302<br/>

http://publicationslist.org/susan.coort/refid7 2008-06-27T17:01:59Z

Glucose and long-chain fatty acids (LCFA) are two major substrates used by heart and skeletal muscle to support contractile activity. In quiescent cardiac myocytes a substantial portion of the glucose transporter GLUT4 and the putative LCFA transporter fatty acid translocase (FAT)/CD36 are stored in intracellular compartments. Induction of cellular contraction by electrical stimulation results in ...<br/><br/>Joost J F P Luiken, Susan L M Coort, Debby P Y Koonen, Arend Bonen, Jan F C Glatz (2004) <i>Proc Nutr Soc</i> <i></i> <i></i> 63: 2 251-258<br/>

http://publicationslist.org/susan.coort/refid8 2008-06-27T17:01:59Z

Fatty acid (FA) translocase (FAT)/CD36 is a key protein involved in regulating the uptake of FA across the plasma membrane in heart and skeletal muscle. A null mutation of FAT/CD36 reduces FA uptake rates and metabolism, while its overexpression increases FA uptake rates and metabolism. FA uptake into the myocyte may be regulated (a) by altering the expression of FAT/CD36, thereby increasing the p...<br/><br/>Arend Bonen, Shannon E Campbell, Carley R Benton, Adrian Chabowski, Susan L M Coort, Xiao-Xia Han, Debby P Y Koonen, Jan F C Glatz, Joost J F P Luiken (2004) <i>Proc Nutr Soc</i> <i></i> <i></i> 63: 2 245-249<br/>

http://publicationslist.org/susan.coort/refid11 2008-06-27T17:03:24Z

In cardiac myocytes, uptake rates of glucose and long-chain fatty acids (FA) are regulated by translocation of GLUT4 and FA translocase (FAT)/CD36, respectively, from intracellular stores to the sarcolemma. Insulin and contractions are two major physiological stimuli able to induce translocation of both transporters and therefore enhance the uptake of both substrates. Interestingly, the cardiovasc...<br/><br/>Joost J F P Luiken, Susan L M Coort, Jodil Willems, Will A Coumans, Arend Bonen, Jan F C Glatz (2004) <i>Mol Pharmacol</i> <i></i> <i></i> 65: 3 639-645<br/>

http://publicationslist.org/susan.coort/refid13 2008-06-27T17:03:24Z

Disturbed cardiac lipid homoeostasis in obesity is regarded as a key player in the development of cardiovascular diseases. In this study, we show that FAT (fatty acid translocase)/CD36-mediated LCFA (long-chain fatty acid) uptake in cardiac myocytes from young adult obese Zucker rats is markedly increased, but insensitive to insulin. Basal and insulin-induced glucose uptake rates in these myocytes...<br/><br/>S L M Coort, J J F P Luiken, G J van der Vusse, A Bonen, J F C Glatz (2004) <i>Biochem Soc Trans</i> <i></i> <i></i> 32: Pt 1 83-85<br/>

http://publicationslist.org/susan.coort/refid9 2008-06-27T17:01:59Z

In obesity, the development of cardiomyopathy is associated with the accumulation of myocardial triacylglycerols (TAGs), possibly stemming from elevation of myocardial long-chain fatty acid (LCFA) uptake. Because LCFA uptake is regulated by insulin and contractions, we examined in cardiac myocytes from lean and obese Zucker rats the effects of insulin and the contraction-mimetic agent oligomycin o...<br/><br/>Susan L M Coort, Danny M Hasselbaink, Debby P Y Koonen, Jodil Willems, Will A Coumans, Adrian Chabowski, Ger J van der Vusse, Arend Bonen, Jan F C Glatz, Joost J F P Luiken (2004) <i>Diabetes</i> <i></i> <i></i> 53: 7 1655-1663<br/>

http://publicationslist.org/susan.coort/refid12 2008-06-27T17:03:24Z

Cardiac uptake of long-chain fatty acids (FA) is mediated predominantly by two membrane-associated proteins, the 43-kDa plasma membrane fatty acid-binding protein (FABPpm) and the 88-kDa fatty acid translocase/CD36 (FAT/CD36). While FABPpm is present constitutively in the sarcolemma, FAT/CD36 is recycled between an intracellular membrane compartment and the sarcolemma. Since the amount of sarcolem...<br/><br/>Joost J F P Luiken, Susan L M Coort, Debby P Y Koonen, Dick J van der Horst, Arend Bonen, Antonio Zorzano, Jan F C Glatz (2004) <i>Pflugers Arch</i> <i></i> <i></i> 448: 1 1-15<br/>

http://publicationslist.org/susan.coort/refid10 2008-06-27T17:01:59Z

Because insulin has been shown to stimulate long-chain fatty acid (LCFA) esterification in skeletal muscle and cardiac myocytes, we investigated whether insulin increased the rate of LCFA transport by altering the expression and the subcellular distribution of the fatty acid transporters FAT/CD36 and FABPpm. In cardiac myocytes, insulin very rapidly increased the expression of FAT/CD36 protein in ...<br/><br/>Adrian Chabowski, Susan L M Coort, Jorge Calles-Escandon, Narendra N Tandon, Jan F C Glatz, Joost J F P Luiken, Arend Bonen (2004) <i>Am J Physiol Endocrinol Metab</i> <i></i> <i></i> 287: 4 E781-E789<br/>

http://publicationslist.org/susan.coort/refid15 2008-06-27T17:03:24Z

Contraction of rat cardiac myocytes induces translocation of fatty acid translocase (FAT)/CD36 and GLUT4 from intracellular stores to the sarcolemma, leading to enhanced rates of long-chain fatty acid (FA) and glucose uptake, respectively. Because intracellular AMP/ATP is elevated in contracting cardiac myocytes, we investigated whether activation of AMP-activated protein kinase (AMP kinase) is in...<br/><br/>Joost J F P Luiken, Susan L M Coort, Jodil Willems, Will A Coumans, Arend Bonen, Ger J van der Vusse, Jan F C Glatz (2003) <i>Diabetes</i> <i></i> <i></i> 52: 7 1627-1634<br/>

http://publicationslist.org/susan.coort/refid14 2008-06-27T17:03:24Z

In contrast to UCP1, the primary function of UCP3 is not the dissipation of energy. Rather, several lines of evidence suggest that UCP3 is related to cellular long-chain fatty acid homeostasis. If long-chain fatty acids enter the mitochondrial matrix in their non-esterified form, they cannot be metabolized and may exert deleterious effects. To test the feasibility that UCP3 exports fatty acid anio...<br/><br/>Patrick Schrauwen, Joris Hoeks, Gert Schaart, Esther Kornips, Bert Binas, Ger J Van De Vusse, Marc Van Bilsen, Joost J F P Luiken, Susan L M Coort, Jan F C Glatz, Wim H M Saris, Matthijs K C Hesselink (2003) <i>FASEB J</i> <i></i> <i></i> 17: 15 2272-2274<br/>

http://publicationslist.org/susan.coort/refid17 2008-06-27T17:03:24Z

Recently, we established that cellular contractions increase long-chain fatty-acid (FA) uptake by cardiac myocytes. This increase is dependent on the transport function of an 88 kDa membrane FA transporter, FA translocase (FAT/CD36), and, in analogy to skeletal muscle, is likely to involve its translocation from an intracellular pool to the sarcolemma. In the present study, we investigated whether...<br/><br/>J J F P Luiken, J Willems, S L M Coort, W A Coumans, A Bonen, G J Van Der Vusse, J F C Glatz (2002) <i>Biochem J</i> <i></i> <i></i> 367: Pt 3 881-887<br/>

http://publicationslist.org/susan.coort/refid16 2008-06-27T17:03:24Z

Sulfo-N-succinimidyl esters of LCFAs are a powerful tool to investigate the functional significance of plasmalemmal proteins in the LCFA uptake process. This notion is based on the following observations. First, sulfo-N-succinimidyl oleate (SSO) was found to inhibit the bulk of LCFA uptake into various cell types, i.e. rat adipocytes, type II pneumocytes and cardiac myocytes. Second, using cardiac...<br/><br/>Susan L M Coort, Jodil Willems, Will A Coumans, Ger J van der Vusse, Arend Bonen, Jan F C Glatz, Joost J F P Luiken (2002) <i>Mol Cell Biochem</i> <i></i> <i></i> 239: 1-2 213-219<br/>