http://publicationslist.org/data/takanori.eguchi/atom.xml Takanori EGUCHIhttp://publicationslist.org/takanori.eguchi$basepathfavicon.icoRecent additions to Takanori EGUCHI's PublicationsList.org pagehttp://publicationslist.org/publications.png2011-07-28T16:46:31Z http://publicationslist.org/takanori.eguchi/refid17 2009-01-08T06:41:07Z

CCN2/CTGF is a multifunctional factor that plays a crucial role in the growth and differentiation of chondrocytes. The chicken ccn2 gene is regulated not only at the transcriptional level but also by the interaction between a posttranscriptional element in the 3' untranslated region (3'-UTR) and a cofactor. In the present study, we identified a nucleophosmin (NPM) (also called B23) as this cofacto...<br/><br/>Yoshiki Mukudai, Satoshi Kubota, Harumi Kawaki, Seiji Kondo, Takanori Eguchi, Kumi Sumiyoshi, Toshihiro Ohgawara, Tsuyoshi Shimo, Masaharu Takigawa (2008) <i>Mol Cell Biol</i> 28: 19 6134-6147<br/>

http://publicationslist.org/takanori.eguchi/refid1 2008-05-26T08:37:42Z

Matrix metalloproteinase 3 (MMP3) is well known as a secretory endopeptidase that degrades extracellular matrices. Recent reports indicated the presence of MMPs in the nucleus (A. J. Kwon et al., FASEB J. 18:690-692, 2004); however, its function has not been well investigated. Here, we report a novel function of human nuclear MMP3 as a trans regulator of connective tissue growth factor (CCN2/CTGF)...<br/><br/>Takanori Eguchi, Satoshi Kubota, Kazumi Kawata, Yoshiki Mukudai, Junji Uehara, Toshihiro Ohgawara, Soichiro Ibaragi, Akira Sasaki, Takuo Kuboki, Masaharu Takigawa (2008) <i>Mol Cell Biol</i> 28: 7 2391-2413<br/>

http://publicationslist.org/takanori.eguchi/refid3 2011-07-28T16:42:55Z

Connective tissue growth factor (CTGF/CCN2) plays a critical role in endochondral bone formation; however, CCN2 also promotes angiogenesis and bone metastasis in breast cancer. Chondrocytic HCS-2/8 cells and breast cancer MDA231 cells produce over 6 times more CCN2 than any other cell type. In this study, we demonstrate that these cell lines employ different transcriptional strategies for ccn2 gen...<br/><br/>Takanori Eguchi, Satoshi Kubota, Kazumi Kawata, Yoshiki Mukudai, Toshihiro Ohgawara, Kohei Miyazono, Kyouji Nakao, Seiji Kondo, Masaharu Takigawa (2007) <i>Biochimie</i> <i></i> <i></i> 89: 3 278-288<br/>

http://publicationslist.org/takanori.eguchi/refid2 2008-04-16T04:14:56Z

CCN2/connective tissue growth factor (CCN2/CTGF) is a critical signaling modulator of mesenchymal tissue development. This study investigated the localization and expression of CCN2/CTGF as a factor supporting angiogenesis and chondrogenesis during development of secondary ossification centers in the mouse tibial epiphysis. Formation of the secondary ossification center was initiated by cartilage ...<br/><br/>Morihiko Oka, Satoshi Kubota, Seiji Kondo, Takanori Eguchi, Chisa Kuroda, Kazumi Kawata, Shogo Minagi, Masaharu Takigawa (2007) <i>J Histochem Cytochem</i> <i></i> <i></i> 55: 12 1245-1255<br/>

http://publicationslist.org/takanori.eguchi/refid5 2008-04-16T04:14:56Z

Low density lipoprotein receptor (LDLR)-related protein 1 (LRP1/CD91) is one of the receptors of CCN2 that conducts endochondral ossification and cartilage repair. LRP1 is a well-known endocytic receptor, but its distribution among chondrocytes remains to be elucidated. We herein demonstrate for the first time that the distribution of LRP1 in chondrocytes except for hypertrophic chondrocytes in vi...<br/><br/>Kazumi Kawata, Takanori Eguchi, Satoshi Kubota, Harumi Kawaki, Morihiko Oka, Shogo Minagi, Masaharu Takigawa (2006) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 345: 2 552-559<br/>

http://publicationslist.org/takanori.eguchi/refid4 2008-04-16T04:14:56Z

The role of CTGF/CCN2 in osteolytic metastasis by breast cancer cells and its mechanism of action were studied. Osteolytic metastasis accompanied by CCN2 and PTHrP overproduction was efficiently inhibited by an anti-CCN2 antibody. Furthermore, we found that CCN2 was induced by PTHrP through PKA-, PKC-, and ERK-mediated pathways therein. INTRODUCTION: Connective tissue growth factor (CTGF/CCN2) is ...<br/><br/>Tsuyoshi Shimo, Satoshi Kubota, Norie Yoshioka, Soichiro Ibaragi, Sachiko Isowa, Takanori Eguchi, Akira Sasaki, Masaharu Takigawa (2006) <i>J Bone Miner Res</i> <i></i> <i></i> 21: 7 1045-1059<br/>

http://publicationslist.org/takanori.eguchi/refid6 2008-04-16T04:14:56Z

It is known that expression of the macrophage colony-stimulating factor (M-CSF) gene is induced in articular chondrocytes upon inflammation. However, the functional role of M-CSF in cartilage has been unclear. In this study, we describe possible roles of M-CSF in the protection and maintenance of the articular cartilage based on the results of experiments using human chondrocytic cells and rat pri...<br/><br/>Kyouji Nakao, Satoshi Kubota, Hideyuki Doi, Takanori Eguchi, Morihiko Oka, Takuo Fujisawa, Takashi Nishida, Masaharu Takigawa (2005) <i>Bone</i> <i></i> <i></i> 36: 5 884-892<br/>

http://publicationslist.org/takanori.eguchi/refid7 2008-04-16T04:14:56Z

CCN2/CTGF is a multifunctional growth factor. Our previous studies have revealed that CCN2 plays important roles in both growth and differentiation of chondrocytes and that the 3'-untranslated region (3'-UTR) of ccn2 mRNA contains a cis-repressive element of gene expression. In the present study, we found that the stability of chicken ccn2 mRNA is regulated in a differentiation stage-dependent man...<br/><br/>Yoshiki Mukudai, Satoshi Kubota, Takanori Eguchi, Seiji Kondo, Kyouji Nakao, Masaharu Takigawa (2005) <i>J Biol Chem</i> <i></i> <i></i> 280: 5 3166-3177<br/>

http://publicationslist.org/takanori.eguchi/refid8 2008-04-16T04:14:56Z

The expression of the connective tissue growth factor ( ctgf) gene increases along with the differentiation of growth cartilage cells, and the highest expression is observed in the hypertrophic stage. Similarly, recent reports demonstrated c- fos expression in chondrocytes in the early hypertrophic zone of growth cartilage, and suggested that the c- fos gene may play a crucial role in the regulati...<br/><br/>Norifumi H Moritani, Satoshi Kubota, Takanori Eguchi, Tomohiro Fukunaga, Takashi Yamashiro, Teruko Takano-Yamamoto, Hideki Tahara, Kazumi Ohyama, Toshio Sugahara, Masaharu Takigawa (2003) <i>J Bone Miner Metab</i> <i></i> <i></i> 21: 4 205-210<br/>

http://publicationslist.org/takanori.eguchi/refid9 2008-04-16T04:14:56Z

To clarify the chondrocyte-specific regulatory mechanism of connective tissue growth factor (ctgf) gene expression, we analyzed the functionality and DNA-protein interaction of the CTGF promoter. Comparative luciferase assay of the CTGF promoter deletion mutants among HCS-2/8 chondrocytic cells and fibroblastic cells revealed that a 110-bp region in the promoter was crucial for the HCS-2/8-specifi...<br/><br/>Takanori Eguchi, Satoshi Kubota, Seiji Kondo, Takuo Kuboki, Hirofumi Yatani, Masaharu Takigawa (2002) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 295: 2 445-451<br/>

http://publicationslist.org/takanori.eguchi/refid10 2008-04-16T04:14:56Z

Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here we investigated how CTGF and matrix metalloproteinases (MMPs) are involved in the early stage of hypoxia-induced angiogenesis using human breast cancer cell line, MDA231, and vascular endothelial cells. Hypoxic stimulation (5% O(2)) of MDA231 cells increased their steady-state level of ctgf mRNA by approximately...<br/><br/>Seiji Kondo, Satoshi Kubota, Tsuyoshi Shimo, Takashi Nishida, Gen Yosimichi, Takanori Eguchi, Toshio Sugahara, Masaharu Takigawa (2002) <i>Carcinogenesis</i> <i></i> <i></i> 23: 5 769-776<br/>

http://publicationslist.org/takanori.eguchi/refid12 2008-04-16T04:14:56Z

The synthesis, processing, and secretion of human connective tissue growth factor (CTGF/Hcs24) in a human chondrocytic cell line, HCS-2/8, were analyzed immunochemically. By metabolic pulse-labeling, chasing, and subsequent immunoprecipitation analyses, active synthesis of CTGF was observed not only in growing HCS-2/8 cells, but also in confluent cells. However, secretion and processing of CTGF we...<br/><br/>S Kubota, T Eguchi, T Shimo, T Nishida, T Hattori, S Kondo, T Nakanishi, M Takigawa (2001) <i>Bone</i> <i></i> <i></i> 29: 2 155-161<br/>

http://publicationslist.org/takanori.eguchi/refid13 2008-04-16T04:14:56Z

CTGF/Hcs24 is a multi-functional growth factor that potentiates either the growth or differentiation of mesenchymal cells, according to the biological conditions. Among various functional aspects of CTGF/Hcs24, it is especially notable that CTGF/Hcs24 may promote endochondral ossification in growth cartilage through all stages, and it is highly expressed in a human chondrosarcoma-derived chondrocy...<br/><br/>T Eguchi, S Kubota, S Kondo, T Shimo, T Hattori, T Nakanishi, T Kuboki, H Yatani, M Takigawa (2001) <i>J Biochem</i> <i></i> <i></i> 130: 1 79-87<br/>

http://publicationslist.org/takanori.eguchi/refid11 2008-04-16T04:14:56Z

The human T-cell leukemia virus type I Tax protein (HTLV-I Tax) is known as a trans-activating factor for a variety of genes, including those of cytokines. Here, we show that Tax is capable of activating the herpes simplex virus thymidine kinase (HSV-TK) promoter in certain mammalian cell lines. In murine NIH 3T3 fibroblasts and human HeLa cells, trans-activation by Tax was remarkably strong, wher...<br/><br/>S Kubota, Y Mukudai, T Hattori, T Eguchi, S Kondo, M Takigawa (2001) <i>DNA Cell Biol</i> <i></i> <i></i> 20: 9 563-568<br/>

http://publicationslist.org/takanori.eguchi/refid15 2008-04-16T04:14:56Z

The repressive effect of the 3'-untranslated region (3'-UTR) in human connective tissue growth factor/ hypertrophic chondrocyte specific 24 (ctgf/hcs24) mRNA on gene expression had been demonstrated in our previous study. Here, we identified a minimal RNA element in the 3'-UTR, which acts as a cis-acting element of structure-anchored repression (CAESAR). Deletion analyses of the 3'-UTR led us to m...<br/><br/>S Kubota, S Kondo, T Eguchi, T Hattori, T Nakanishi, R J Pomerantz, M Takigawa (2000) <i>Oncogene</i> <i></i> <i></i> 19: 41 4773-4786<br/>

http://publicationslist.org/takanori.eguchi/refid14 2008-04-16T04:14:56Z

We isolated a small segment of the 3'-untranslated region (3'-UTR) in the mouse connective tissue growth factor (ctgf/fisp12) gene and evaluated its functionality. Comparison of the nucleotide sequences of human and mouse ctgf 3'-UTRs revealed a conserved small segment of 91 bases. The corresponding segments of the 3'-UTRs shared as much as 82.4% homology, whereas the overall homology between the ...<br/><br/>S Kondo, S Kubota, T Eguchi, T Hattori, T Nakanishi, T Sugahara, M Takigawa (2000) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 278: 1 119-124<br/>

http://publicationslist.org/takanori.eguchi/refid16 2009-01-08T06:38:33Z

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