http://publicationslist.org/data/takeshi.imai/atom.xml Takeshi Imaihttp://publicationslist.org/takeshi.imai$basepathfavicon.icoRecent additions to Takeshi Imai's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-03-11T06:27:01Z http://publicationslist.org/takeshi.imai/refid2 2010-03-11T06:16:31Z

In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR...<br/><br/>T Imai, H Sakano (2009) <i>Results Probl Cell Differ</i> <i></i> <i></i> 47: 57-75<br/>

http://publicationslist.org/takeshi.imai/refid1 2010-03-11T06:16:31Z

Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and ...<br/><br/>Takeshi Imai, Takahiro Yamazaki, Reiko Kobayakawa, Ko Kobayakawa, Takaya Abe, Misao Suzuki, Hitoshi Sakano (2009) <i>Science</i> <i></i> <i></i> 325: 5940 585-590<br/>

http://publicationslist.org/takeshi.imai/refid3 2010-03-11T06:16:31Z

In the mouse olfactory system, there are approximately 1000 types of odorant receptors (ORs), which perform multiple functions in olfactory sensory neurons (OSNs). In addition to detecting odors, the functional OR protein ensures the singular gene choice of the OR by negative-feedback regulation. ORs also direct the axonal projection of OSNs both globally and locally by modulating the transcriptio...<br/><br/>Takeshi Imai, Hitoshi Sakano (2008) <i>Curr Opin Neurobiol</i> <i></i> <i></i> 18: 3 251-260<br/>

http://publicationslist.org/takeshi.imai/refid4 2010-03-11T06:16:31Z

In mammals, olfactory sensory neurons project their axons exclusively to the ipsilateral olfactory bulb. It remains unclear how odor information interacts between the two hemispheres of the brain. In this issue of Neuron, Yan et al. describe the precise interbulbar connection through the anterior olfactory nucleus pars externa (AONpE), which links contralateral isotypic olfactory columns.<br/><br/>Takeshi Imai, Hitoshi Sakano (2008) <i>Neuron</i> <i></i> <i></i> 58: 4 465-467<br/>

http://publicationslist.org/takeshi.imai/refid6 2010-03-11T06:16:31Z

In V(D)J recombination, the RAG1 and RAG2 protein complex cleaves the recombination signal sequences (RSSs), generating a hairpin structure at the coding end. The cleavage occurs only between two RSSs with different spacer lengths of 12 and 23 bp. Here we report that in the synaptic complex, recombination-activating gene (RAG) proteins interact with the 7-mer and unstack the adjacent base in the c...<br/><br/>Tadashi Nishihara, Fumikiyo Nagawa, Takeshi Imai, Hitoshi Sakano (2008) <i>J Biol Chem</i> <i></i> <i></i> 283: 8 4877-4885<br/>

http://publicationslist.org/takeshi.imai/refid8 2010-03-11T06:16:31Z

In the mouse olfactory epithelium, there are about ten million olfactory sensory neurons, each expressing a single type of odorant receptor out of approximately 1000. Olfactory sensory neurons expressing the same odorant receptor converge their axons to a specific set of glomeruli on the olfactory bulb. How odorant receptors play an instructive role in the projection of axons to the olfactory bulb...<br/><br/>Takeshi Imai, Hitoshi Sakano (2007) <i>Curr Opin Neurobiol</i> <i></i> <i></i> 17: 5 507-515<br/>

http://publicationslist.org/takeshi.imai/refid7 2010-03-11T06:16:31Z

The mammalian olfactory system mediates various responses, including aversive behaviours to spoiled foods and fear responses to predator odours. In the olfactory bulb, each glomerulus represents a single species of odorant receptor. Because a single odorant can interact with several different receptor species, the odour information received in the olfactory epithelium is converted to a topographic...<br/><br/>Ko Kobayakawa, Reiko Kobayakawa, Hideyuki Matsumoto, Yuichiro Oka, Takeshi Imai, Masahito Ikawa, Masaru Okabe, Toshio Ikeda, Shigeyoshi Itohara, Takefumi Kikusui, Kensaku Mori, Hitoshi Sakano (2007) <i>Nature</i> <i></i> <i></i> 450: 7169 503-508<br/>

http://publicationslist.org/takeshi.imai/refid5 2010-03-11T06:16:31Z

Takeshi Imai, Hitoshi Sakano (2007) <i>Seikagaku</i> <i></i> <i></i> 79: 12 1148-1152<br/>

http://publicationslist.org/takeshi.imai/refid10 2010-03-11T06:16:31Z

Vertebrate odorant receptor (OR) genes are divided phylogenetically into two distinct classes: the fish-like class I and the terrestrial-specific class II. In the present study, we systematically analysed mouse class I OR genes (42 subfamilies) to elucidate the expression profiles in the olfactory epithelium (OE) and the projection sites of their olfactory sensory neurons (OSNs) in the olfactory b...<br/><br/>Akio Tsuboi, Takaaki Miyazaki, Takeshi Imai, Hitoshi Sakano (2006) <i>Eur J Neurosci</i> <i></i> <i></i> 23: 6 1436-1444<br/>

http://publicationslist.org/takeshi.imai/refid9 2010-03-11T06:16:31Z

In mammals, odorant receptors (ORs) direct the axons of olfactory sensory neurons (OSNs) toward targets in the olfactory bulb. We show that cyclic adenosine monophosphate (cAMP) signals that regulate the expression of axon guidance molecules are essential for the OR-instructed axonal projection. Genetic manipulations of ORs, stimulatory G protein, cAMP-dependent protein kinase, and cAMP response e...<br/><br/>Takeshi Imai, Misao Suzuki, Hitoshi Sakano (2006) <i>Science</i> <i></i> <i></i> 314: 5799 657-661<br/>

http://publicationslist.org/takeshi.imai/refid11 2010-03-11T06:17:28Z

In rodents, olfactory receptor (OR) genes are expressed in one of four zones in the olfactory epithelium (OE), and olfactory sensory neurons (OSNs) expressing the same OR project their axons to a specific set of glomeruli on the olfactory bulb (OB). Using the yeast artificial chromosome (YAC) transgenic system, we have analysed the expression of the murine OR gene MOR29A of the MOR28 cluster locat...<br/><br/>Hiroko Nakatani, Shou Serizawa, Miho Nakajima, Takeshi Imai, Hitoshi Sakano (2003) <i>Eur J Neurosci</i> <i></i> <i></i> 18: 9 2425-2432<br/>