http://publicationslist.org/data/tetsuo.shoji/atom.xml Tetsuo Shojihttp://publicationslist.org/tetsuo.shoji$basepathfavicon.icoRecent additions to Tetsuo Shoji's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-04-10T04:09:12Z http://publicationslist.org/tetsuo.shoji/refid102 2008-04-10T04:01:47Z

BACKGROUND: Full, as compared with partial, correction of anaemia did not reduce the mortality risk in patients with chronic kidney disease (CKD), although the underlying mechanisms are unknown. Since CKD is a high-risk population for cardiovascular disease (CVD), we tested a hypothesis that the presence of atherosclerosis affects the relationship between anaemia and mortality risk. METHODS: We pe...<br/><br/> Maekawa, Shoji, Emoto, Okuno, Yamakawa, Ishimura, Inaba, Nishizawa (2008) <i>Nephrol Dial Transplant</i> <i></i> <i></i> : <br/>

http://publicationslist.org/tetsuo.shoji/refid103 2008-04-10T04:01:47Z

Vascular calcification is highly prevalent in dialysis patients, and significantly increases cardiovascular mortality. The presence and progression of vascular calcification is significantly associated with chronic inflammation and malnutrition. Disorders of mineral metabolism, particularly hyperphosphatemia, have been emphasized as risk factors for vascular calcification. Although vascular calcif...<br/><br/>Eiji Ishimura, Senji Okuno, Hiromichi Taniwaki, Akane Kizu, Takao Tsuchida, Atsushi Shioi, Tetsuo Shoji, Tsutomu Tabata, Masaaki Inaba, Yoshiki Nishizawa (2008) <i>Kidney Blood Press Res</i> <i></i> <i></i> 31: 1 10-15<br/>

http://publicationslist.org/tetsuo.shoji/refid107 2008-04-10T04:01:47Z

Impaired activation of vitamin D in renal failure results in bone and mineral abnormalities, and causes renal osteodystrophy or chronic kidney disease mineral and bone disorder (CKD-MBD). Recent studies suggest that deficiency of active vitamin D is also involved in abnormalities in blood pressure, cardiac hypertrophy, atherosclerosis, glucose intolerance and immune dysfunction that are known as c...<br/><br/>Tetsuo Shoji, Yoshiki Nishizawa (2007) <i>Clin Calcium</i> <i></i> <i></i> 17: 5 691-697<br/>

http://publicationslist.org/tetsuo.shoji/refid108 2008-04-10T04:01:47Z

OBJECTIVE: Fetuin-A is a circulating glycoprotein which is well characterized as an inhibitor of ectopic calcification. Vascular calcification commonly found in chronic kidney disease (CKD) patients is a predictor of cardiovascular death. Recently, several groups have demonstrated that low fetuin-A levels are associated with mortality in uraemic patients, possibly through regulation of vascular ca...<br/><br/>Katsuhito Mori, Masanori Emoto, Takahiro Araki, Hisayo Yokoyama, Megumi Teramura, Eiko Lee, Koka Motoyama, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2007) <i>Clin Endocrinol (Oxf)</i> <i></i> <i></i> 66: 2 246-250<br/>

http://publicationslist.org/tetsuo.shoji/refid110 2008-04-10T04:01:47Z

OBJECTIVE: Receptor for advanced glycation end-products (RAGE) is involved in diabetic vascular complications. We have recently shown that plasma endogenously secretory RAGE (esRAGE), an alternatively spliced form of RAGE, is closely associated with metabolic syndrome and atherosclerosis. Here, we evaluated if plasma esRAGE is a predictor of cardiovascular mortality in a cohort of 206 (171 nondiab...<br/><br/>Hidenori Koyama, Tetsuo Shoji, Shinya Fukumoto, Kayo Shinohara, Takuhito Shoji, Masanori Emoto, Katsuhito Mori, Hideki Tahara, Eiji Ishimura, Ryusuke Kakiya, Tsutomu Tabata, Hiroshi Yamamoto, Yoshiki Nishizawa (2007) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 27: 1 147-153<br/>

http://publicationslist.org/tetsuo.shoji/refid109 2008-04-10T04:01:47Z

BACKGROUND: Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental models. So far, no study has examined its role in atherosclerosis in human subjects. We evaluated the possible association between plasma ANGPTL3 level and carotid artery intima-media thickness (CA-IMT) and femoral artery...<br/><br/>Sawako Hatsuda, Tetsuo Shoji, Kayo Shinohara, Eiji Kimoto, Katsuhito Mori, Shinya Fukumoto, Hidenori Koyama, Masanori Emoto, Yoshiki Nishizawa (2007) <i>J Vasc Res</i> <i></i> <i></i> 44: 1 61-66<br/>

http://publicationslist.org/tetsuo.shoji/refid106 2008-04-10T04:01:47Z

BACKGROUND: A close relationship has been reported between microalbuminuria and atherosclerosis in patients with diabetes mellitus. The aim of this study was to determine which of the 2 aspects of atherosclerosis, arterial thickening or stiffness, has more effect on levels of microalbuminuria in type 2 diabetic patients. METHODS: Twenty-four-hour urine samples of 167 Japanese type 2 diabetic patie...<br/><br/>Eiji Ishimura, Hiromichi Taniwaki, Takao Tsuchida, Naoko Obatake, Masanori Emoto, Tetsuo Shoji, Atsushi Shioi, Masaaki Inaba, Yoshiki Nishizawa (2007) <i>J Nephrol</i> <i></i> <i></i> 20: 2 204-211<br/>

http://publicationslist.org/tetsuo.shoji/refid105 2008-04-10T04:01:47Z

AIM: The present study aimed to clarify the clinical impact of modified NCEP-ATP III criteria for metabolic syndrome (MS) and Framingham Risk Score (FRS) on carotid atherosclerosis in 615 Japanese adults (319 men and 296 women) including 307 with type 2 diabetes. METHODS: Waist circumference was the only component from the original NCEP-ATP III criteria based on Japanese criteria. The intima-media...<br/><br/>Megumi Teramura, Masanori Emoto, Takahiro Araki, Hisayo Yokoyama, Koka Motoyama, Kayo Shinohara, Katsuhito Mori, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2007) <i>J Atheroscler Thromb</i> <i></i> <i></i> 14: 4 172-178<br/>

http://publicationslist.org/tetsuo.shoji/refid104 2008-04-10T04:01:47Z

PURPOSE OF REVIEW: The paradoxical and inverse association between body mass index and mortality risk in patients with end-stage renal disease has raised a question of whether an increased fat mass is good or bad for patients with chronic kidney disease. The purpose of this review is to update the concept on body fat in patients with chronic kidney disease. RECENT FINDINGS: A greater fat mass is a...<br/><br/>Tetsuo Shoji, Eiji Ishimura, Yoshiki Nishizawa (2007) <i>Curr Opin Nephrol Hypertens</i> <i></i> <i></i> 16: 6 572-576<br/>

http://publicationslist.org/tetsuo.shoji/refid111 2008-04-10T04:01:47Z

Yoshiki Nishizawa, Tetsuo Shoji (2006) <i>Nat Clin Pract Nephrol</i> <i></i> <i></i> 2: 7 352-353<br/>

http://publicationslist.org/tetsuo.shoji/refid112 2008-04-10T04:01:47Z

Patients with advanced stages of chronic kidney disease (CKD) have an increased risk of death from cardiovascular disease (CVD). Dyslipidemias are associated with atherosclerotic vascular changes and the risk of occurrence of acute myocardial infarction in hemodialysis patients. However, management of dyslipidemia in hemodialysis patients does not appear to be actively carried out in routine pract...<br/><br/>Tetsuo Shoji, Yoshiki Nishizawa (2006) <i>Ther Apher Dial</i> <i></i> <i></i> 10: 4 305-315<br/>

http://publicationslist.org/tetsuo.shoji/refid96 2008-04-10T04:01:47Z

CONTEXT: Impaired nonoxidative glucose disposal and decrease in mitochondrial glucose oxidation both contribute to insulin resistance in diabetic subjects. OBJECTIVE: In the present study, we investigated whether plasma adiponectin is associated with glucose oxidation and nonoxidative glucose disposal in subjects with and without type 2 diabetes. DESIGN: Euglycemic-hyperinsulinemic clamp was perfo...<br/><br/>Hisayo Yokoyama, Masanori Emoto, Katsuhito Mori, Takahiro Araki, Megumi Teramura, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2006) <i>J Clin Endocrinol Metab</i> <i></i> <i></i> 91: 1 290-294<br/>

http://publicationslist.org/tetsuo.shoji/refid97 2008-04-10T04:01:47Z

Adiponectin, an adipokine secreted specifically from adipose tissue, has plurifunctions including antidiabetic, antiatherosclerotic, and antiinflammatory functions. Recently, platelet activation and the subsequent local inflammation have been implicated in progression of atherosclerosis. The aim of the study is to examine the interrelation among plasma adiponectin levels, platelet activation statu...<br/><br/>Takuhito Shoji, Hidenori Koyama, Shinya Fukumoto, Takaaki Maeno, Hisayo Yokoyama, Kayo Shinohara, Masanori Emoto, Tetsuo Shoji, Takahisa Yamane, Masayuki Hino, Atsushi Shioi, Yoshiki Nishizawa (2006) <i>Atherosclerosis</i> <i></i> <i></i> 188: 1 190-195<br/>

http://publicationslist.org/tetsuo.shoji/refid101 2008-04-10T04:01:47Z

Adiponectin plays important roles in protecting against both insulin resistance and the development of atherosclerosis. The aim of the present study was to investigate the clinical impact of plasma adiponectin on arterial stiffness, a functional property of atherosclerosis, in type 2 diabetic and nondiabetic subjects. We evaluated plasma adiponectin levels and stiffness index beta for the common c...<br/><br/>Takahiro Araki, Masanori Emoto, Hisayo Yokoyama, Takaaki Maeno, Sawako Hatsuda, Katsuhito Mori, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2006) <i>Metabolism</i> <i></i> <i></i> 55: 5 587-592<br/>

http://publicationslist.org/tetsuo.shoji/refid113 2008-04-10T04:01:47Z

Angiogenic response is impaired in diabetes. Here, we examined the involvement of receptor for advanced glycation end products (RAGE) in diabetes-related impairment of angiogenesis in vivo. Angiogenesis was determined in reconstituted basement membrane protein (matrigel) plugs containing vascular endothelial growth factor (VEGF) implanted into nondiabetic or insulin-deficient diabetic wild-type or...<br/><br/>Takuhito Shoji, Hidenori Koyama, Tomoaki Morioka, Shinji Tanaka, Akane Kizu, Kohka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Noriko Shimogaito, Masayoshi Takeuchi, Yasuhiko Yamamoto, Hideto Yonekura, Hiroshi Yamamoto, Yoshiki Nishizawa (2006) <i>Diabetes</i> <i></i> <i></i> 55: 8 2245-2255<br/>

http://publicationslist.org/tetsuo.shoji/refid100 2008-04-10T04:01:47Z

Katsuhito Mori, Masanori Emoto, Hisayo Yokoyama, Takahiro Araki, Megumi Teramura, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2006) <i>Diabetes Care</i> <i></i> <i></i> 29: 2 <br/>

http://publicationslist.org/tetsuo.shoji/refid120 2008-04-10T04:01:47Z

Arterial stiffness is increased in type 2 diabetes mellitus, and diabetes preferentially affects arterial stiffness of the central (elastic, capacitive) over peripheral (muscular, conduit) arteries. We hypothesized that arterial stiffness of the central artery may be more closely associated with ischemic heart disease (IHD) than stiffness of peripheral arteries in type 2 diabetes mellitus. The sub...<br/><br/>Sawako Hatsuda, Tetsuo Shoji, Kayo Shinohara, Eiji Kimoto, Katsuhito Mori, Shinya Fukumoto, Hidenori Koyama, Masanori Emoto, Yoshiki Nishizawa (2006) <i>J Atheroscler Thromb</i> <i></i> <i></i> 13: 2 114-121<br/>

http://publicationslist.org/tetsuo.shoji/refid114 2008-04-10T04:01:47Z

Adiponectin, an adipocyte-specific plasma protein, has been reported to exhibit protective effects against atherosclerosis as well as an insulin-sensitizing effect. This study was designed to investigate the effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin. Twenty type 2 diabetic patients were enrolled and divided into 2 groups...<br/><br/>Takahiro Araki, Masanori Emoto, Megumi Teramura, Hisayo Yokoyama, Katsuhito Mori, Sawako Hatsuda, Takaaki Maeno, Kayo Shinohara, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2006) <i>Metabolism</i> <i></i> <i></i> 55: 8 996-1001<br/>

http://publicationslist.org/tetsuo.shoji/refid119 2008-04-10T04:01:47Z

A higher body mass index (BMI) is a predictor of better survival in hemodialysis patients, although the relative importance of body fat and lean mass has not been examined in the dialysis population. We performed an observational cohort study in 808 patients with end-stage renal disease on maintenance hemodialysis. At baseline, fat mass was measured by dual-energy X-ray absorptiometry and expresse...<br/><br/>R Kakiya, T Shoji, Y Tsujimoto, N Tatsumi, S Hatsuda, K Shinohara, E Kimoto, H Tahara, H Koyama, M Emoto, E Ishimura, T Miki, T Tabata, Y Nishizawa (2006) <i>Kidney Int</i> <i></i> <i></i> 70: 3 549-556<br/>

http://publicationslist.org/tetsuo.shoji/refid118 2008-04-10T04:01:47Z

OBJECTIVE: To investigate the impact of glycemic control during regular hemodialysis on the survival of diabetic patients with chronic kidney disease (CKD) in a longitudinal observational study. RESEARCH DESIGN AND METHODS: A total of 114 diabetic CKD patients on hemodialysis at Inoue Hospital (Suita, Japan) were surveyed from May 1995 to December 2002 (survey period 45.5 +/- 29.3 [means +/- SD] m...<br/><br/>Takeshi Oomichi, Masanori Emoto, Tsutomu Tabata, Tomoaki Morioka, Yoshihiro Tsujimoto, Hideki Tahara, Tetsuo Shoji, Yoshiki Nishizawa (2006) <i>Diabetes Care</i> <i></i> <i></i> 29: 7 1496-1500<br/>

http://publicationslist.org/tetsuo.shoji/refid115 2008-04-10T04:01:47Z

Increased arterial stiffness is an independent predictor of death from cardiovascular disease, and aortic stiffness is more predictive than stiffness of other arterial regions. Because little is known about the effect of chronic kidney disease (CKD) on regional arterial stiffness, pulse wave velocity (PWV) of four different arterial segments was measured in patients who had type 2 diabetes with an...<br/><br/>Eiji Kimoto, Tetsuo Shoji, Kayo Shinohara, Sawako Hatsuda, Katsuhito Mori, Shinya Fukumoto, Hidenori Koyama, Masanori Emoto, Yasuhisa Okuno, Yoshiki Nishizawa (2006) <i>J Am Soc Nephrol</i> <i></i> <i></i> 17: 8 2245-2252<br/>

http://publicationslist.org/tetsuo.shoji/refid116 2008-04-10T04:01:47Z

Death rate is unacceptably elevated in end-stage renal disease patients treated with hemodialysis. Excessive body fat, or obesity, is the well-known risk factor for cardiovascular disease and other health problems in the general population. However, hemodialysis patients with a higher body mass index (BMI) have a lower risk of death, as shown by many studies. There are several explanations for the...<br/><br/>Yoshiki Nishizawa, Tetsuo Shoji, Eiji Ishimura (2006) <i>J Ren Nutr</i> <i></i> <i></i> 16: 3 241-244<br/>

http://publicationslist.org/tetsuo.shoji/refid117 2008-04-10T04:01:47Z

Active vitamin D plays important roles not only in bone and mineral metabolism but also in the cardiovascular system. Cohort studies in hemodialysis patients demonstrated that use of active vitamin D analogs was associated with reduced risk of death, particularly death from cardiovascular disease. Treatment with vitamin D had beneficial effects on cardiac and immune functions in dialysis patients,...<br/><br/>Tetsuo Shoji, Yoshiki Nishizawa (2006) <i>Clin Calcium</i> <i></i> <i></i> 16: 7 1107-1114<br/>

http://publicationslist.org/tetsuo.shoji/refid93 2008-04-10T04:01:47Z

Sevelamer hydrochloride (SH) is widely used for the treatment of hyperphosphatemia in patients with renal failure who are on maintenance hemodialysis. In this study, we investigated the clinical effects of SH, administered as either monotherapy or combined with a calcium carbonate formulation, on the metabolism of calcium (Ca) and phosphorus (P) in patients who had been taking a Ca-based binder. P...<br/><br/>Hideki Tahara, Yoshihiro Tsujimoto, Tetsuo Shoji, Masaaki Inaba, Tsutomu Tabata, Yoshiki Nishizawa (2005) <i>Ther Apher Dial</i> <i></i> <i></i> 9 Suppl 1: S2-S6<br/>

http://publicationslist.org/tetsuo.shoji/refid94 2008-04-10T04:01:47Z

OBJECTIVE: A statin, a potent lipid-lowering drug, improves pain-free walking distance in patients with peripheral arterial disease (PAD) without increasing the ankle-brachial pressure index (ABI). Arterial stiffness affects the blood flow of peripheral arteries. The purpose of this study was to evaluate the effect of cholesterol-lowering with atorvastatin on regional arterial stiffness in patient...<br/><br/>Kayo Shinohara, Tetsuo Shoji, Eiji Kimoto, Hisayo Yokoyama, Shigehiko Fujiwara, Sawako Hatsuda, Takaaki Maeno, Takuhito Shoji, Shinya Fukumoto, Masanori Emoto, Hidenori Koyama, Yoshiki Nishizawa (2005) <i>J Atheroscler Thromb</i> <i></i> <i></i> 12: 4 205-210<br/>

http://publicationslist.org/tetsuo.shoji/refid91 2008-04-10T04:01:47Z

BACKGROUND: Although an increased serum phosphate concentration is a significant risk factor for vascular calcification, it is unclear whether serum phosphate level is a risk factor for increased arterial wall thickness in hemodialysis patients. METHODS: Using B-mode ultrasonography, we examined intima-medial thickness (IMT) of the carotid artery of hemodialysis patients and analyzed risk factors ...<br/><br/>Eiji Ishimura, Hiromichi Taniwaki, Tsutomu Tabata, Yoshihiro Tsujimoto, Shuichi Jono, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba, Takashi Inoue, Yoshiki Nishizawa (2005) <i>Am J Kidney Dis</i> <i></i> <i></i> 45: 5 859-865<br/>

http://publicationslist.org/tetsuo.shoji/refid82 2008-04-10T04:01:47Z

The aim of this cross-sectional study was to investigate whether physical activity and local arterial thickening may affect bone metabolism. To analyze the effects of physical activity and atherosclerosis on bone in healthy Japanese people, health-related quality of life (HRQL) and local arterial thickening were assessed by means of the Medical( )Outcomes Study 36-item Short Form (SF-36), and inti...<br/><br/>Shinsuke Yamada, Masaaki Inaba, Hitoshi Goto, Mayumi Nagata, Misako Ueda, Kiyoshi Nakatuka, Hideki Tahara, Hisayo Yokoyama, Masanori Emoto, Tetsuo Shoji, Yoshiki Nishizawa (2005) <i>Osteoporos Int</i> <i></i> <i></i> 16: 1 64-70<br/>

http://publicationslist.org/tetsuo.shoji/refid95 2008-04-10T04:01:47Z

OBJECTIVE: Advanced glycation endproducts, AGEs, and its specific receptor, RAGE, are involved in diabetic vascular complications. Endogenous secretory RAGE, esRAGE, has been identified as an alternatively spliced form of RAGE, and shown to act as a decoy receptor for AGE. Here, we measured plasma esRAGE level with a recently developed enzyme-linked immunosorbent assay (ELISA) and examined its ass...<br/><br/>Hidenori Koyama, Takuhito Shoji, Hisayo Yokoyama, Kohka Motoyama, Katsuhito Mori, Shinya Fukumoto, Masanori Emoto, Tetsuo Shoji, Hironori Tamei, Hirokazu Matsuki, Shigeru Sakurai, Yasuhiko Yamamoto, Hideto Yonekura, Takuo Watanabe, Hiroshi Yamamoto, Yoshiki Nishizawa (2005) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 25: 12 2587-2593<br/>

http://publicationslist.org/tetsuo.shoji/refid88 2008-04-10T04:01:47Z

Patients with end-stage renal disease (ESRD) show an inverse association between body mass index and risk of death from cardiovascular disease. Paradoxical epidemiology may suggest some beneficial effects of body fat in ESRD. Because an antiatherogenic adipocytokine adiponectin is increased in uremic plasma, we tested a hypothesis that, in ESRD, plasma adipocytokine profile may be less atherogenic...<br/><br/>Tetsuo Shoji, Kayo Shinohara, Sawako Hatsuda, Eiji Kimoto, Shinya Fukumoto, Masanori Emoto, Hideki Tahara, Hidenori Koyama, Eiji Ishimura, Takami Miki, Tsutomu Tabata, Yoshiki Nishizawa (2005) <i>Metabolism</i> <i></i> <i></i> 54: 3 330-334<br/>

http://publicationslist.org/tetsuo.shoji/refid89 2008-04-10T04:01:47Z

Intercellular adhesion molecule-1 (ICAM-1) is involved in inflammation and development of atherosclerotic change of vascular endothelium. The aim of the present study is to investigate whether K469E polymorphism of the ICAM-1 gene is associated with various clinical factors including plasma fibrinogen in patients with type 2 diabetes. ICAM-1 gene polymorphism was examined using polymerase chain re...<br/><br/>Hisayo Yokoyama, Hideki Tahara, Masanori Emoto, Shigehiko Fujiwara, Takahiro Araki, Kayo Shinohara, Sawako Hatsuda, Takaaki Maeno, Takuhito Shoji, Hidenori Koyama, Tetsuo Shoji, Yoshiki Nishizawa (2005) <i>Metabolism</i> <i></i> <i></i> 54: 3 381-386<br/>

http://publicationslist.org/tetsuo.shoji/refid90 2008-04-10T04:01:47Z

Patients with chronic kidney disease (CKD) have an increased risk for death from cardiovascular disease (CVD). They have multiple metabolic abnormalities that may accelerate atherosclerosis, such as hypertension, insulin resistance, and dyslipidemia, along with other CKD-related risk factors. In addition, a considerable proportion of patients with advanced stages of CKD are malnourished, presentin...<br/><br/>Tetsuo Shoji, Yoshiki Nishizawa (2005) <i>Intern Med</i> <i></i> <i></i> 44: 3 179-187<br/>

http://publicationslist.org/tetsuo.shoji/refid92 2008-04-10T04:01:47Z

BACKGROUND: Certain metabolic disorders, such as hyperphosphatemia induce vascular calcification in haemodialysis patients; it is unclear, however, whether these disorders contribute to aortic calcification in diabetic haemodialysis patients. This study examined the risk factors of aortic calcification in a large number of haemodialysis patients, and compared risk factors between diabetic and non-...<br/><br/>Hiromichi Taniwaki, Eiji Ishimura, Tsutomu Tabata, Yoshihiro Tsujimoto, Atushi Shioi, Tetsuo Shoji, Masaaki Inaba, Takashi Inoue, Yoshiki Nishizawa (2005) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 20: 11 2472-2478<br/>

http://publicationslist.org/tetsuo.shoji/refid121 2008-04-10T04:01:47Z

It is well-known that secondary hyperparathyroidism of uremia influences not only bone and mineral metabolism but also cardiovascular complications. Here we reported the effects of the level of serum intact PTH and its gene polymorphism on cardiovascular and non-cardiovascular mortality in hemodialysis patients. We analyzed the association between clinico-molecular parameters and 3-year survival i...<br/><br/>Yoshihiro Tsujimoto, Tsutomu Tabata, Takashi Inoue, Hideki Tahara, Tetsuo Shoji, Kayo Shinohara, Masaaki Inaba, Yoshiki Nishizawa (2005) <i>Clin Calcium</i> <i></i> <i></i> 15 Suppl 1: 106-9; discussion 109<br/>

http://publicationslist.org/tetsuo.shoji/refid122 2008-04-10T04:01:47Z

Yoshiki Nishizawa, Tetsuo Shoji, Hidenori Koyama, Masanori Emoto (2005) <i>Nippon Naika Gakkai Zasshi</i> <i></i> <i></i> 94: 3 485-489<br/>

http://publicationslist.org/tetsuo.shoji/refid99 2008-04-10T04:01:47Z

Recent evidence suggests important roles for platelet activation in the progression of atherosclerosis. We have recently shown that P-selectin expression or the presence of platelet-monocyte aggregates, a well-characterized marker of platelet activation, is associated with carotid atherosclerosis in the general population. It is not clear, however, whether platelet activation is also associated wi...<br/><br/>Takuhito Shoji, Hidenori Koyama, Shinya Fukumoto, Takaaki Maeno, Hisayo Yokoyama, Kayo Shinohara, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2005) <i>J Atheroscler Thromb</i> <i></i> <i></i> 12: 6 344-352<br/>

http://publicationslist.org/tetsuo.shoji/refid98 2008-04-10T04:01:47Z

BACKGROUND: It is difficult to predict the hypoglycemic effect of pioglitazone (a thiazolidinedione) as an insulin sensitizer. The purpose of the present study was to investigate whether insulin resistance index, homeostasis model assessment index (HOMA-IR) is a useful predictor of hypoglycemic effect of pioglitazone in comparison with body mass index (BMI). METHODS: Thirty-four type 2 diabetic pa...<br/><br/>Takahiro Araki, Masanori Emoto, Hisayo Yokoyama, Koka Motoyama, Tomoaki Morioka, Hideki Tahara, Hidenori Koyama, Tetsuo Shoji, Yasuhisa Okuno, Masaaki Inaba, Yoshiki Nishizawa (2005) <i>Osaka City Med J</i> <i></i> <i></i> 51: 1 19-25<br/>

http://publicationslist.org/tetsuo.shoji/refid83 2008-04-10T04:01:47Z

Tetsuo Shoji, Eiji Kimoto, Kayo Shinohara, Sawako Hatsuda, Yoshiki Nishizawa (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 7 1937-1938<br/>

http://publicationslist.org/tetsuo.shoji/refid81 2008-04-10T04:01:47Z

BACKGROUND: Fibroblast growth factor (FGF)-23 is a recently identified circulating factor which causes renal phosphate wasting disorders. Although the mechanism of regulation of FGF-23 secretion is unknown, plasma FGF-23 level may be regulated or affected by serum phosphate levels because of its hypophosphatemic effect. METHODS: We tested the hypothesis that plasma FGF-23 levels may be increased i...<br/><br/>Yasuo Imanishi, Masaaki Inaba, Kiyoshi Nakatsuka, Kyoko Nagasue, Senji Okuno, Asami Yoshihara, Masakazu Miura, Akimitsu Miyauchi, Keisuke Kobayashi, Takami Miki, Tetsuo Shoji, Eiji Ishimura, Yoshiki Nishizawa (2004) <i>Kidney Int</i> <i></i> <i></i> 65: 5 1943-1946<br/>

http://publicationslist.org/tetsuo.shoji/refid79 2008-04-10T04:01:47Z

BACKGROUND: Hemodialysis patients have advanced arterial wall stiffening as shown by increased aortic pulse wave velocity (PWV), an independent predictor of cardiovascular mortality. We compared aortic PWV of uremic patients before starting hemodialysis treatment with that of patients on maintenance hemodialysis. METHODS: The subjects were 71 patients with end-stage renal disease (ESRD) before sta...<br/><br/>Kayo Shinohara, Tetsuo Shoji, Yoshihiro Tsujimoto, Eiji Kimoto, Hideki Tahara, Hidenori Koyama, Masanori Emoto, Eiji Ishimura, Takami Miki, Tsutomu Tabata, Yoshiki Nishizawa (2004) <i>Kidney Int</i> <i></i> <i></i> 65: 3 936-943<br/>

http://publicationslist.org/tetsuo.shoji/refid76 2008-04-10T04:01:47Z

BACKGROUND: Renal failure results in deficiency of active vitamin D3 that has diverse effects on metabolism and organ functions. Treatment with active forms of vitamin D(3) ameliorates abnormalities in bone and mineral metabolism, cardiac function, immune response and others. We hypothesized that treatment with vitamin D(3) may be beneficial for survival in patients with end-stage renal disease (E...<br/><br/>Tetsuo Shoji, Kayo Shinohara, Eiji Kimoto, Masanori Emoto, Hideki Tahara, Hidenori Koyama, Masaaki Inaba, Shinya Fukumoto, Eiji Ishimura, Takami Miki, Tsutomu Tabata, Yoshiki Nishizawa (2004) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 19: 1 179-184<br/>

http://publicationslist.org/tetsuo.shoji/refid78 2008-04-10T04:01:47Z

Atherosclerosis has two key components, thickening and stiffening of arterial wall. These parameters are quantified ultrasonographically by IMT (intima-media thickness) and PWV (pulse wave velocity). In the present study, we determined the FA IMT (IMT of the bilateral femoral artery) and PWV of femoral-ankle (PWV fa) and brachial-ankle (PWV ba) segments in order to examine whether the degree of at...<br/><br/>Reiko Okabe, Masaaki Inaba, Shinrei Sakai, Eiji Ishimura, Atsushi Moriguchi, Tetsuo Shoji, Yoshiki Nishizawa (2004) <i>Clin Sci (Lond)</i> <i></i> <i></i> 106: 6 613-618<br/>

http://publicationslist.org/tetsuo.shoji/refid85 2008-04-10T04:01:47Z

OBJECTIVE: To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes. METHODS: Common carotid and femoral arterial stiffness was ultrasonographically evaluated using stiffness index beta in 23 type 2 diabetic subjects before and after a 3-week exercise protocol including ...<br/><br/>Hisayo Yokoyama, Masanori Emoto, Shigehiko Fujiwara, Koka Motoyama, Tomoaki Morioka, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2004) <i>Diabetes Res Clin Pract</i> <i></i> <i></i> 65: 2 85-93<br/>

http://publicationslist.org/tetsuo.shoji/refid80 2008-04-10T04:01:47Z

The purpose of the study was to investigate whether quantitative insulin sensitivity check index (QUICKI) and the reciprocal index of homeostasis model assessment (1/HOMA-IR) are excellent surrogate indexes of insulin resistance in type 2 diabetic patients with various ranges of fasting plasma glucose. One hundred eight type 2 diabetic patients were divided into tertiles according to fasting level...<br/><br/>Hisayo Yokoyama, Masanori Emoto, Shigehiko Fujiwara, Koka Motoyama, Tomoaki Morioka, Miyoko Komatsu, Hideki Tahara, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2004) <i>J Clin Endocrinol Metab</i> <i></i> <i></i> 89: 3 1481-1484<br/>

http://publicationslist.org/tetsuo.shoji/refid84 2008-04-10T04:01:47Z

Hisayo Yokoyama, Masanori Emoto, Takahiro Araki, Shigehiko Fujiwara, Koka Motoyama, Tomoaki Morioka, Hidenori Koyama, Tetsuo Shoji, Yasuhisa Okuno, Yoshiki Nishizawa (2004) <i>Diabetes Care</i> <i></i> <i></i> 27: 7 1756-1758<br/>

http://publicationslist.org/tetsuo.shoji/refid125 2008-04-10T04:01:47Z

Tetsuo Shoji, Yoshiki Nishizawa (2004) <i>Nippon Rinsho</i> <i></i> <i></i> 62 Suppl 6: 339-342<br/>

http://publicationslist.org/tetsuo.shoji/refid123 2008-04-10T04:01:47Z

Vitamin D receptors are expressed not only in the classical target organs (bone, parathyroid glands, kidneys and intestine) but also in other non-classical targets including arteries, heart, immune system, endocrine organs, and nervous system. Therefore, the deficiency of active forms of vitamin D in uremia may explain various abnormalities in biological functions and survival disadvantage in this...<br/><br/>Tetsuo Shoji, Yoshiki Nishizawa (2004) <i>Clin Calcium</i> <i></i> <i></i> 14: 9 64-68<br/>

http://publicationslist.org/tetsuo.shoji/refid124 2008-04-10T04:01:47Z

Eiko Lee, Hideki Tahara, Takuhito Shoji, Mayumi Nagata, Misako Ueda, Shinsuke Yamada, Hitoshi Goto, Masaaki Inaba, Yoshiki Nishizawa (2004) <i>Clin Calcium</i> <i></i> <i></i> 14: 3 462-465<br/>

http://publicationslist.org/tetsuo.shoji/refid87 2008-04-10T04:01:47Z

Patients with end-stage renal disease have markedly increased risk for death from cardiovascular disease. Renal failure is associated with multiple metabolic and endocrinologic abnormalities, and these alterations are involved in advanced atherosclerosis and high cardiovascular risk. Increased insulin resistance index by homeostasis model assessment (HOMA-IR), a simple index of insulin resistance,...<br/><br/>Yoshiki Nishizawa, Tetsuo Shoji, Masanori Emoto, Hideki Koyama, Hideki Tahara, Shinya Fukumoto, Masaaki Inaba, Eiji Ishimura, Takami Miki (2004) <i>Semin Nephrol</i> <i></i> <i></i> 24: 5 423-425<br/>

http://publicationslist.org/tetsuo.shoji/refid86 2008-04-10T04:01:47Z

Although evidence has accumulated indicating a close relationship between inflammation and atherosclerosis, the relationship between inflammation and vascular calcification in patients with chronic renal failure is unclear. In the present study, the relationship between C-reactive protein (CRP) and vascular calcification in dialysis patients was examined. Vascular calcification of the aorta and ha...<br/><br/>Eiji Ishimura, Senji Okuno, Kayoko Kitatani, Kiyoshi Maekawa, Tsuyoshi Izumotani, Tomoyuki Yamakawa, Shuichi Jono, Tetsuo Shoji, Atsushi Shioi, Masaaki Inaba, Shaul G Massry, Yoshiki Nishizawa (2004) <i>Semin Nephrol</i> <i></i> <i></i> 24: 5 408-412<br/>

http://publicationslist.org/tetsuo.shoji/refid67 2008-04-10T04:01:47Z

OBJECTIVE: Hyperglycemia and hypertension are known to be risk factors for the development of proteinuria in patients with diabetes. Little is known, however, about predictors of progression of renal failure in diabetic patients. RESEARCH DESIGN AND METHODS: We investigated factors affecting progression of renal failure by measuring the doubling of serum creatinine (s-Cr) as an end point in a coho...<br/><br/>Hideki Ueda, Eiji Ishimura, Tetsuo Shoji, Masanori Emoto, Tomoaki Morioka, Naoki Matsumoto, Shinya Fukumoto, Takami Miki, Masaaki Inaba, Yoshiki Nishizawa (2003) <i>Diabetes Care</i> <i></i> <i></i> 26: 5 1530-1534<br/>

http://publicationslist.org/tetsuo.shoji/refid68 2008-04-10T04:01:47Z

BACKGROUND: Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects. METHODS AND RESULTS: Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with...<br/><br/>Hidenori Koyama, Takaaki Maeno, Shinya Fukumoto, Takuhito Shoji, Takahisa Yamane, Hisayo Yokoyama, Masanori Emoto, Tetsuo Shoji, Hideki Tahara, Masaaki Inaba, Masayuki Hino, Atsushi Shioi, Takami Miki, Yoshiki Nishizawa (2003) <i>Circulation</i> <i></i> <i></i> 108: 5 524-529<br/>

http://publicationslist.org/tetsuo.shoji/refid69 2008-04-10T04:01:47Z

The aim of the present study is to investigate whether Met416Val (M416V) polymorphism of glycogen synthase (GYS1) gene is associated with insulin resistance in type 2 diabetes. In 100 type 2 diabetic subjects (66 men and 34 women), the M416V polymorphism of GYS1 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) as previously reported, and insulin re...<br/><br/>Koka Motoyama, Masanori Emoto, Hideki Tahara, Miyoko Komatsu, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2003) <i>Metabolism</i> <i></i> <i></i> 52: 7 895-899<br/>

http://publicationslist.org/tetsuo.shoji/refid66 2008-04-10T04:01:47Z

BACKGROUND: Immune response to oxidized low-density lipoprotein (oxLDL) may modulate atherogenesis. We recently reported that a high titer of serum anti-oxLDL antibody was an independent predictor of a low risk for cardiovascular death in patients with end-stage renal disease (ESRD). In the present study, we examined a possible association between anti-oxLDL antibody titer and arterial wall thickn...<br/><br/>Tetsuo Shoji, Eiji Kimoto, Kayo Shinohara, Masanori Emoto, Eiji Ishimura, Takami Miki, Yoshihiro Tsujimoto, Tsutomu Tabata, Yoshiki Nishizawa (2003) <i>Kidney Int Suppl</i> <i></i> <i></i> : 84 S128-S130<br/>

http://publicationslist.org/tetsuo.shoji/refid70 2008-04-10T04:01:47Z

OBJECTIVE: To investigate whether the quantitative insulin sensitivity check index (QUICKI) and the reciprocal index of homeostasis model assessment (1/HOMA-IR) derived from fasting plasma glucose and insulin level are excellent surrogate indices of insulin resistance in both normal range-weight and moderately obese type 2 diabetic and healthy subjects. RESEARCH DESIGN AND METHODS: The association...<br/><br/>Hisayo Yokoyama, Masanori Emoto, Shigehiko Fujiwara, Koka Motoyama, Tomoaki Morioka, Miyoko Komatsu, Hideki Tahara, Tetsuo Shoji, Yasuhisa Okuno, Yoshiki Nishizawa (2003) <i>Diabetes Care</i> <i></i> <i></i> 26: 8 2426-2432<br/>

http://publicationslist.org/tetsuo.shoji/refid60 2008-04-10T04:01:47Z

OBJECTIVE: ACE inhibitors are known to be effective in preventing the progression of diabetic nephropathy. Activation of the renin-angiotensin system (RAS) is reported to contribute to intrarenal hemodynamic abnormality in diabetic patients. We examined whether RAS blockade by captopril induces intrarenal hemodynamic changes in normotensive patients with type 2 diabetes. RESEARCH DESIGN AND METHOD...<br/><br/>Hiromichi Taniwaki, Eiji Ishimura, Takahiko Kawagishi, Naoki Matsumoto, Masayuki Hosoi, Masanori Emoto, Tetsuo Shoji, Shigeichi Shoji, Tatsuya Nakatani, Masaaki Inaba, Yoshiki Nishizawa (2003) <i>Diabetes Care</i> <i></i> <i></i> 26: 1 132-137<br/>

http://publicationslist.org/tetsuo.shoji/refid63 2008-04-10T04:01:47Z

BACKGROUND: Cardiovascular disease is the leading cause of death in patients with end-stage renal disease (ESRD). Previous studies showed that patients with ESRD had increased intima-media thickness of the carotid artery (CA-IMT). In the present study, we examined whether CA-IMT would predict cardiovascular mortality in patients with ESRD. METHODS: The cohort consisted of 438 patients with ESRD tr...<br/><br/>Yoshiki Nishizawa, Tetsuo Shoji, Kiyoshi Maekawa, Kyoko Nagasue, Senji Okuno, Masao Kim, Masanori Emoto, Eiji Ishimura, Tatsuya Nakatani, Takami Miki, Masaaki Inaba (2003) <i>Am J Kidney Dis</i> <i></i> <i></i> 41: 3 Suppl 1 S76-S79<br/>

http://publicationslist.org/tetsuo.shoji/refid61 2008-04-10T04:01:47Z

Arterial stiffness affects cardiac functions, peripheral circulation, and cardiovascular mortality. We examined whether arterial stiffness in different regions is equally affected by diabetes and other factors. The subjects were 161 patients with type 2 diabetes and 129 healthy subjects comparable in age and sex. Arterial stiffness was evaluated by measuring pulse wave velocity (PWV) in the heart-...<br/><br/>Eiji Kimoto, Tetsuo Shoji, Kayo Shinohara, Masaaki Inaba, Yasuhisa Okuno, Takami Miki, Hidenori Koyama, Masanori Emoto, Yoshiki Nishizawa (2003) <i>Diabetes</i> <i></i> <i></i> 52: 2 448-452<br/>

http://publicationslist.org/tetsuo.shoji/refid64 2008-04-10T04:01:47Z

BACKGROUND: Changes in body fat mass in a large number of hemodialysis patients is unknown. METHODS: Body fat mass and lean body mass were measured by dual x-ray absorptiometry (DXA) in 561 patients with hemodialysis duration less than 180 months (62.3 +/- 11.5 years old; mean +/- SD). RESULTS: Fat mass tended to increase during the first 3 years of hemodialysis, and it tended to decrease thereaft...<br/><br/>Eiji Ishimura, Senji Okuno, Taro Marukawa, Yoshikazu Katoh, Toshiyuki Hiranaka, Tomoyuki Yamakawa, Hirotoshi Morii, Masao Kim, Naoki Matsumoto, Tetsuo Shoji, Masaaki Inaba, Tatsuya Nakatani, Yoshiki Nishizawa (2003) <i>Am J Kidney Dis</i> <i></i> <i></i> 41: 3 Suppl 1 S137-S141<br/>

http://publicationslist.org/tetsuo.shoji/refid65 2008-04-10T04:01:47Z

BACKGROUND: Patients with end-stage renal disease (ESRD) often show lipid abnormalities that may promote atherosclerosis. Although the standard lipid marker is low-density lipoprotein cholesterol (LDL-C) in official recommendations, the need of fasting blood sampling has prevented routine screening for plasma lipids in hemodialysis patients. METHODS: We therefore evaluated the power of non-high-de...<br/><br/>Yoshiki Nishizawa, Tetsuo Shoji, Ryusuke Kakiya, Yoshihiro Tsujimoto, Tsutomu Tabata, Eiji Ishimura, Tatsuya Nakatani, Takami Miki, Masaaki Inaba (2003) <i>Kidney Int Suppl</i> <i></i> <i></i> : 84 S117-S120<br/>

http://publicationslist.org/tetsuo.shoji/refid71 2008-04-10T04:01:47Z

The prevalence of peripheral vascular disease (PVD) in diabetic patients is manyfold higher than that of age- and sex-matched nondiabetic subjects. This study was designed to evaluate the relationship between quantitatively determined peripheral circulation in the lower extremities and arterial wall thickness or stiffness in 68 patients with type 2 diabetes. Peripheral circulation during treadmill...<br/><br/>Akane Kizu, Hidenori Koyama, Shinji Tanaka, Takaaki Maeno, Miyoko Komatsu, Shinya Fukumoto, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba, Atsushi Shioi, Takami Miki, Yoshiki Nishizawa (2003) <i>Atherosclerosis</i> <i></i> <i></i> 170: 1 87-91<br/>

http://publicationslist.org/tetsuo.shoji/refid75 2008-04-10T04:01:47Z

OBJECTIVE: We recently reported that rheumatoid arthritis (RA) patients had increased intima-media thickness (IMT) of the common carotid artery (CCA). The present longitudinal study was performed to determine whether the change in arterial thickness was accelerated in RA patients and to determine which factor was important in the progression of arterial wall changes. METHODS: We studied 62 female ...<br/><br/>Mayumi Nagata-Sakurai, Masaaki Inaba, Hitoshi Goto, Yasuro Kumeda, Yutaka Furumitsu, Kentaro Inui, Hidenori Koyama, Masanori Emoto, Eiji Ishimura, Tetsuo Shoji, Yoshiki Nishizawa (2003) <i>Arthritis Rheum</i> <i></i> <i></i> 48: 11 3061-3067<br/>

http://publicationslist.org/tetsuo.shoji/refid74 2008-04-10T04:01:47Z

BACKGROUND: Although vitamin D has been reported to be useful in the treatment of patients with secondary hyperparathyroidism, it is not effective in some of them. The goal of this study was to see whether a relationship could be found between maxacalcitol responsiveness and parathyroid gland size. METHODS: Parathyroid gland size was measured by ultrasonography in 25 patients with secondary hyperp...<br/><br/>Senji Okuno, Eiji Ishimura, Kayoko Kitatani, Hidenori Chou, Kyoko Nagasue, Kiyoshi Maekawa, Tsuyoshi Izumotani, Tomoyuki Yamakawa, Yasuo Imanishi, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2003) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 18: 12 2613-2621<br/>

http://publicationslist.org/tetsuo.shoji/refid77 2008-04-10T04:01:47Z

Tetsuo Shoji, Yoshiki Nishizawa (2003) <i>Intern Med</i> <i></i> <i></i> 42: 11 1061-1062<br/>

http://publicationslist.org/tetsuo.shoji/refid73 2008-04-10T04:01:47Z

OBJECTIVE: Patients with type 2 diabetes mellitus are at an increased risk of atherosclerosis including peripheral arterial disease (PAD). The purpose of this study was to examine the possible alteration in pulse wave velocity (PWV) in lower-limb arteries among diabetic patients with PAD. METHODS: We measured brachial-ankle PWV (baPWV) using an automatic device in 101 healthy control subjects and ...<br/><br/>Hisayo Yokoyama, Tetsuo Shoji, Eiji Kimoto, Kayo Shinohara, Shinji Tanaka, Hidenori Koyama, Masanori Emoto, Yoshiki Nishizawa (2003) <i>J Atheroscler Thromb</i> <i></i> <i></i> 10: 4 253-258<br/>

http://publicationslist.org/tetsuo.shoji/refid72 2008-04-10T04:01:47Z

The aim of the present study was to investigate the independent association of the intimal-medial thickness of carotid and femoral arteries (CA-IMT and FA-IMT), a marker of atheroscelosis, with insulin resistance in type 2 diabetic patients. We evaluated CA-IMT and FA-IMT by high-resolution ultrasonography and insulin resistance determined by euglycemic hyperinsulinemic clamp in 119 type 2 diabeti...<br/><br/>Shigehiko Fujiwara, Masanori Emoto, Miyoko Komatsu, Koka Motoyama, Tomoaki Morioka, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba, Yoshiki Nishizawa (2003) <i>J Atheroscler Thromb</i> <i></i> <i></i> 10: 4 246-252<br/>

http://publicationslist.org/tetsuo.shoji/refid54 2008-04-10T04:01:47Z

Insulin resistance is closely associated with atherosclerosis and cardiovascular mortality in the general population. Patients with end-stage renal disease (ESRD) are known to have insulin resistance, advanced atherosclerosis, and a high cardiovascular mortality rate. We evaluated whether insulin resistance is a predictor of cardiovascular death in a cohort of ESRD. A prospective observational coh...<br/><br/>Kayo Shinohara, Tetsuo Shoji, Masanori Emoto, Hideki Tahara, Hidenori Koyama, Eiji Ishimura, Takami Miki, Tsutomu Tabata, Yoshiki Nishizawa (2002) <i>J Am Soc Nephrol</i> <i></i> <i></i> 13: 7 1894-1900<br/>

http://publicationslist.org/tetsuo.shoji/refid55 2008-04-10T04:01:47Z

OBJECTIVE: To determine whether arterial wall thickening is advanced in rheumatoid arthritis (RA) patients compared with healthy controls by measuring the intima-media thickness (IMT) of the common carotid and femoral arteries, and to evaluate the factors associated with arterial IMT in patients with RA. METHODS: We studied 138 RA patients and 94 healthy controls (matched for age, sex, and other m...<br/><br/>Yasuro Kumeda, Masaaki Inaba, Hitoshi Goto, Mayumi Nagata, Yasuko Henmi, Yutaka Furumitsu, Eiji Ishimura, Kentaro Inui, Yasutaka Yutani, Takami Miki, Tetsuo Shoji, Yoshiki Nishizawa (2002) <i>Arthritis Rheum</i> <i></i> <i></i> 46: 6 1489-1497<br/>

http://publicationslist.org/tetsuo.shoji/refid53 2008-04-10T04:01:47Z

Diabetic bone disease is characterized by low bone turnover resulting from either impaired secretion of parathyroid hormone (PTH) or refractoriness of osteoblasts to PTH. The present study was performed to elucidate which factor contributes more to the reduction in bone turnover by comparison between 64 hemodialyzed patients with diabetes mellitus and 106 hemodialyzed patients without diabetes mel...<br/><br/>Masaaki Inaba, Kyoko Nagasue, Senji Okuno, Misako Ueda, Yasuro Kumeda, Yasuo Imanishi, Tetsuo Shoji, Eiji Ishimura, Tomohiro Ohta, Tatsuya Nakatani, Masao Kim, Yoshiki Nishizawa (2002) <i>Am J Kidney Dis</i> <i></i> <i></i> 39: 6 1261-1269<br/>

http://publicationslist.org/tetsuo.shoji/refid50 2008-04-10T04:01:47Z

BACKGROUND: Few studies have addressed the effect of vasodilatory stimuli on the intrarenal arterial system in type 2 diabetes mellitus (DM), and factors affecting its responsiveness. METHODS: One hundred twenty-four patients with type 2 DM without renal failure were enrolled, and 25 subjects served as controls. Using duplex Doppler sonography, resistive indices (RI) of interlobar arteries were me...<br/><br/>Naoki Matsumoto, Eiji Ishimura, Hiromichi Taniwaki, Masanori Emoto, Tetsuo Shoji, Takahiko Kawagishi, Masaaki Inaba, Yoshiki Nishizawa (2002) <i>Nephrol Dial Transplant</i> <i></i> <i></i> 17: 4 608-613<br/>

http://publicationslist.org/tetsuo.shoji/refid56 2008-04-10T04:01:47Z

The association between endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism and vascular endothelial function has not been clarified. We investigated the impact of ecNOS gene polymorphism on endothelial function in 95 patients with Type 2 diabetes (ecNOS genotype: 4b/b, n = 62; 4b/a, n = 30; 4a/a, n = 3). Flow-mediated (endothelium dependent, FMD) and nitroglycerin-induced (en...<br/><br/>Miyoko Komatsu, Takahiko Kawagishi, Masanori Emoto, Tetsuo Shoji, Atsuko Yamada, Kyoko Sato, Masayuki Hosoi, Yoshiki Nishizawa (2002) <i>Am J Physiol Heart Circ Physiol</i> <i></i> <i></i> 283: 2 H557-H561<br/>

http://publicationslist.org/tetsuo.shoji/refid49 2008-04-10T04:01:47Z

Cholesteryl ester transfer protein (CETP) is a key regulating factor of lipid metabolism, and the polymorphism of its gene may therefore be a candidate for modulating the lipid parameters, altering the susceptibility to atherosclerosis in type 2 diabetic subjects. In a group of 443 unrelated Japanese patients with type 2 diabetes, we studied the B1B2 polymorphism at the CETP locus, which is detect...<br/><br/>Isao Kawasaki, Hideki Tahara, Masanori Emoto, Tetsuo Shoji, Yoshiki Nishizawa (2002) <i>Diabetes</i> <i></i> <i></i> 51: 3 871-874<br/>

http://publicationslist.org/tetsuo.shoji/refid51 2008-04-10T04:01:47Z

Polymorphism of alpha2 integrin (C807T) is shown to be associated with an increased incidence of thrombotic cardiovascular events. However, it is not clear whether this polymorphism is associated with atherosclerotic arterial wall thickening. In this study, we examined the association of C807T polymorphism with arterial wall thickness in 265 control subjects and 272 patients with type 2 diabetes. ...<br/><br/>Takaaki Maeno, Hidenori Koyama, Hideki Tahara, Miyoko Komatsu, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba, Takami Miki, Yasuhisa Okuno, Yoshiki Nishizawa (2002) <i>Diabetes</i> <i></i> <i></i> 51: 5 1523-1528<br/>

http://publicationslist.org/tetsuo.shoji/refid52 2008-04-10T04:01:47Z

BACKGROUND: Atherosclerosis is advanced in hemodialysis patients as shown by increased intima-media thickness of carotid arteries (CA-IMT), although it is not established whether the advanced atherosclerosis results from hemodialysis treatment or from chronic renal failure. The purpose of this study was to evaluate the effects of hemodialysis and renal failure on CA-IMT in patients with chronic re...<br/><br/>Tetsuo Shoji, Masanori Emoto, Tsutomu Tabata, Eiji Kimoto, Kayo Shinohara, Kiyoshi Maekawa, Takahiko Kawagishi, Hideki Tahara, Eiji Ishimura, Yoshiki Nishizawa (2002) <i>Kidney Int</i> <i></i> <i></i> 61: 6 2187-2192<br/>

http://publicationslist.org/tetsuo.shoji/refid57 2008-04-10T04:01:47Z

The peroxisome proliferator-activated receptor (PPAR) gamma is an important regulator of adipocyte differentiation and a modulator of intracellular insulin-signaling events. We examined the roles of the Pro12Ala variant of PPAR gamma2 in obesity and insulin resistance in 402 Japanese patients with type 2 diabetes and 116 control subjects. Among the diabetes subjects, the Pro12Pro homozygotes showe...<br/><br/>Isao Kawasaki, Hideki Tahara, Masanori Emoto, Tetsuo Shoji, Atsushi Shioji, Yasuhisa Okuno, Masaaki Inaba, Yoshiki Nishizawa (2002) <i>Osaka City Med J</i> <i></i> <i></i> 48: 1 23-28<br/>

http://publicationslist.org/tetsuo.shoji/refid62 2008-04-10T04:01:47Z

Elevated intermediate-density lipoprotein (IDL), a remnant lipoprotein, is an independent risk factor for atherosclerosis in patients with end-stage renal disease (ESRD). Since the presence of diabetes mellitus further increases the risk of cardiovascular mortality in ESRD, we examined the effect of diabetes on IDL among ESRD patients. The subjects were 330 healthy control subjects and 287 patient...<br/><br/>Eiji Kimoto, Tetsuo Shoji, Masonori Emoto, Takami Miki, Tsutomu Tabata, Yasuhisa Okuno, Eiji Ishimura, Masaaki Inaba, Yoshiki Nishizawa (2002) <i>J Atheroscler Thromb</i> <i></i> <i></i> 9: 6 305-313<br/>

http://publicationslist.org/tetsuo.shoji/refid126 2008-04-10T04:01:47Z

We have experienced rare cases of membranoproliferative glomerulonephritis (MPGN)-like nephritis, which was seen in siblings. Both the brothers had asymptomatic hematuria and proteinuria at an age before 10, 7 and 4 years old, respectively. Renal biopsy revealed proliferative glomerulonephritis, resembling MPGN type III. The family history showed that their father and grandfather suffered from end...<br/><br/>Hideki Ueda, Eiji Isimura, Senji Okuno, Kiyoshi Maekawa, Tsuyoshi Izumotani, Masao Kim, Naoki Matsumoto, Shinya Fukumoto, Yasuo Imanishi, Masanori Emoto, Tetsuo Shoji, Hideki Wanibuchi, Masaaki Inaba, Yoshiki Nishizawa (2002) <i>Nippon Jinzo Gakkai Shi</i> <i></i> <i></i> 44: 4 420-426<br/>

http://publicationslist.org/tetsuo.shoji/refid59 2008-04-10T04:01:47Z

BACKGROUND: Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease. METHODS: We performed a prospective, observational cohort study in 249 patients with end-stage renal disease (ESRD) to examine whether the serum titer of anti-oxLDL antibody can predict cardiovascular mortality. RESULTS: The median anti-oxLDL antibody titer ...<br/><br/>Tetsuo Shoji, Mariko Fukumoto, Eiji Kimoto, Kayo Shinohara, Masanori Emoto, Hideki Tahara, Hidenori Koyama, Eiji Ishimura, Tatsuya Nakatani, Takami Miki, Yoshihiro Tsujimoto, Tsutomu Tabata, Yoshiki Nishizawa (2002) <i>Kidney Int</i> <i></i> <i></i> 62: 6 2230-2237<br/>

http://publicationslist.org/tetsuo.shoji/refid58 2008-04-10T04:01:47Z

AIM/HYPOTHESIS: Although derangements of calcium and phosphate control have been emphasized as important risk factors for vascular calcification in non-diabetic haemodialysis patients, similar risk factors for diabetic haemodialysis patients are not known. We compared factors affecting peripheral vascular calcification between haemodialysis patients with and without diabetes. METHODS: We examined ...<br/><br/>E Ishimura, S Okuno, K Kitatani, M Kim, T Shoji, T Nakatani, M Inaba, Y Nishizawa (2002) <i>Diabetologia</i> <i></i> <i></i> 45: 10 1446-1448<br/>

http://publicationslist.org/tetsuo.shoji/refid41 2008-04-10T04:01:47Z

Paraoxonase is a high-density lipoprotein (HDL)-bound esterase that hydrolyzes various organophosphorus compounds and protects low-density lipoprotein (LDL) against accumulation of lipid peroxides. Paraoxonase activity is strongly affected by the polymorphism of the paraoxonase gene (PON1) at position 192. In addition, the enzyme activity shows a great variation within each genotype, although the ...<br/><br/>A Yamada, T Shoji, H Tahara, M Emoto, Y Nishizawa (2001) <i>Metabolism</i> <i></i> <i></i> 50: 7 805-811<br/>

http://publicationslist.org/tetsuo.shoji/refid42 2008-04-10T04:01:47Z

Stiffening and thickening of arterial wall are two important components of atherosclerosis. The purpose of this study was to evaluate the effects of femoral artery wall stiffness on clinical manifestation of peripheral vascular disease (PVD) in type 2 diabetes mellitus. The subjects were 315 patients with type 2 diabetes. Presence of intermittent claudication and/or leg pain at rest and reduced an...<br/><br/>H Taniwaki, T Shoji, M Emoto, T Kawagishi, E Ishimura, M Inaba, Y Okuno, Y Nishizawa (2001) <i>Atherosclerosis</i> <i></i> <i></i> 158: 1 207-214<br/>

http://publicationslist.org/tetsuo.shoji/refid40 2008-04-10T04:01:47Z

Cardiovascular risk is increased in patients with diabetic nephropathy. The aim of this study was to examine the relative impacts of albuminuria and renal failure, the two important features of diabetic nephropathy, on potentially atherogenic lipoprotein changes in this condition. The subjects were 160 non-diabetic healthy controls and a total of 200 type 2 diabetes patients with various degrees o...<br/><br/>T Shoji, M Emoto, T Kawagishi, E Kimoto, A Yamada, T Tabata, E Ishimura, M Inaba, Y Okuno, Y Nishizawa (2001) <i>Atherosclerosis</i> <i></i> <i></i> 156: 2 425-433<br/>

http://publicationslist.org/tetsuo.shoji/refid39 2008-04-10T04:01:47Z

OBJECTIVE: To investigate the impact of glycemic control on the survival of diabetic subjects with end-stage renal disease (ESRD) starting hemodialysis treatment. RESEARCH DESIGN AND METHODS: This single-center prospective observational study enrolled 150 diabetic ESRD subjects (109 men and 41 women; age at hemodialysis initiation, 60.5 +/- 10.2 years) at start of hemodialysis between January 1989...<br/><br/>T Morioka, M Emoto, T Tabata, T Shoji, H Tahara, H Kishimoto, E Ishimura, Y Nishizawa (2001) <i>Diabetes Care</i> <i></i> <i></i> 24: 5 909-913<br/>

http://publicationslist.org/tetsuo.shoji/refid38 2008-04-10T04:01:47Z

OBJECTIVE: To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy. RESEARCH DESIGN AND METHODS: Plasma tHcy levels were measured using the enzyme immunoassay method in 75 patients with type 2 diabetes and compared with those in 54 healthy control subjects. Insulin sensitivity indexe...<br/><br/>M Emoto, H Kanda, T Shoji, T Kawagishi, M Komatsu, K Mori, H Tahara, E Ishimura, M Inaba, Y Okuno, Y Nishizawa (2001) <i>Diabetes Care</i> <i></i> <i></i> 24: 3 533-538<br/>

http://publicationslist.org/tetsuo.shoji/refid43 2008-04-10T04:01:47Z

Nutritional status affects well-being and survival in patients who are undergoing hemodialysis. It was examined how maintenance hemodialysis altered body fat mass. In 72 patients with chronic renal failure (age, 62 +/- 12 yr; 42 men, 30 women), body fat was measured by dual x-ray absorptiometry 1 mo after initiation of maintenance hemodialysis and approximately 1 yr later (mean +/- SD, 11 +/- 2 mo...<br/><br/>E Ishimura, S Okuno, M Kim, T Yamamoto, T Izumotani, T Otoshi, T Shoji, M Inaba, Y Nishizawa (2001) <i>J Am Soc Nephrol</i> <i></i> <i></i> 12: 9 1921-1926<br/>

http://publicationslist.org/tetsuo.shoji/refid128 2008-04-10T04:01:47Z

T Shoji, Y Nishizawa (2001) <i>Nippon Rinsho</i> <i></i> <i></i> 59 Suppl 3: 130-135<br/>

http://publicationslist.org/tetsuo.shoji/refid45 2008-04-10T04:01:47Z

Patients with chronic uremia have a substantially elevated risk of death from cardiovascular disease than do the general population. Although uremic and nonuremic groups share some of the risk factors for cardiovascular mortality, such as older age, diabetes, and inflammation, other factors appear to affect cardiovascular mortality in the opposite direction. For example, being overweight and havin...<br/><br/>Y Nishizawa, T Shoji, E Ishimura, M Inaba, H Morii (2001) <i>Am J Kidney Dis</i> <i></i> <i></i> 38: 4 Suppl 1 S4-S7<br/>

http://publicationslist.org/tetsuo.shoji/refid127 2008-04-10T04:01:47Z

MRI and bone scintigraphy of a 64-year-old woman admitted with severe lumbago showed multiple metastatic bone cancer mainly on vertebrae, and breast cancer was found by mammography. After enucleation was performed, treatment with tegafur, tamoxifen and oral bisphosphonate/etidronate was started. Because symptoms associated with bone metastasis worsened, we began to administer 30 mg of pamidronate ...<br/><br/>H Yokoyama, K Nakatsuka, T Shoji, I Kawasaki, M Inaba, Y Nishizawa (2001) <i>Nippon Ronen Igakkai Zasshi</i> <i></i> <i></i> 38: 6 812-815<br/>

http://publicationslist.org/tetsuo.shoji/refid44 2008-04-10T04:01:47Z

Cardiovascular mortality is elevated in patients with end-stage renal disease (ESRD), especially in those with diabetes mellitus. Although the higher cardiovascular death rate in diabetic ESRD patients may be the result of more advanced atherosclerotic changes of the arterial wall, this has not been documented previously. Aortic stiffness was compared between ESRD patients with and without diabete...<br/><br/>T Shoji, M Emoto, K Shinohara, R Kakiya, Y Tsujimoto, H Kishimoto, E Ishimura, T Tabata, Y Nishizawa (2001) <i>J Am Soc Nephrol</i> <i></i> <i></i> 12: 10 2117-2124<br/>

http://publicationslist.org/tetsuo.shoji/refid48 2008-04-10T04:01:47Z

T Shoji, M Emoto, Y Nishizawa (2001) <i>Nephron</i> <i></i> <i></i> 89: 3 348-349<br/>

http://publicationslist.org/tetsuo.shoji/refid47 2008-04-10T04:01:47Z

Diabetes mellitus is a strong risk factor for the progression of atherosclerosis. In patients with chronic renal failure on hemodialysis, advanced atherosclerosis is reported to be present. We examined how renal insufficiency affects intima-medial thickness (IMT) of the carotid and femoral arteries in patients with type 2 diabetes mellitus. IMT was measured by B-mode ultrasonography in 115 patient...<br/><br/>E Ishimura, T Shoji, M Emoto, K Motoyama, K Shinohara, N Matsumoto, H Taniwaki, M Inaba, Y Nishizawa (2001) <i>Am J Kidney Dis</i> <i></i> <i></i> 38: 4 Suppl 1 S186-S190<br/>

http://publicationslist.org/tetsuo.shoji/refid46 2008-04-10T04:01:47Z

Cardiovascular mortality is substantially higher in patients with end-stage renal disease (ESRD). Lipoprotein abnormality in ESRD is one of the possible risk factors for advanced atherosclerosis. Uremic dyslipidemia is characterized by increased plasma triglycerides due to elevated very low density lipoprotein (VLDL) and decreased high-density lipoprotein (HDL). Plasma total or low-density lipopro...<br/><br/>T Shoji, E Ishimura, M Inaba, T Tabata, Y Nishizawa (2001) <i>Am J Kidney Dis</i> <i></i> <i></i> 38: 4 Suppl 1 S30-S33<br/>

http://publicationslist.org/tetsuo.shoji/refid34 2008-04-10T04:01:47Z

BACKGROUND/AIM: In patients with type 2 diabetes mellitus, the relationship between glomerular filtration rate (GFR) and urinary albumin excretion remains an unresolved issue. In order to investigate the early renal function abnormalities, GFR and urinary albumin excretion were assessed, and their relationship was examined in normotensive patients with type 2 diabetes mellitus. METHODS: In a cross...<br/><br/>H Taniwaki, E Ishimura, M Emoto, T Kawagishi, N Matsumoto, T Shoji, T Okamura, M Inaba, Y Nishizawa (2000) <i>Nephron</i> <i></i> <i></i> 86: 1 36-43<br/>

http://publicationslist.org/tetsuo.shoji/refid32 2008-04-10T04:01:47Z

Oxidized low density lipoprotein (oxLDL) has been implicated in the pathogenesis of atherosclerosis. Recent studies have shown that immunization of animals with oxLDL results in suppression of atherogenesis. Antibody against oxLDL (oxLDL Ab) is detectable in human sera, although its biological significance is not well established. We examined the relationship between oxLDL Ab titer and circulating...<br/><br/>T Shoji, Y Nishizawa, M Fukumoto, K Shimamura, J Kimura, H Kanda, M Emoto, T Kawagishi, H Morii (2000) <i>Atherosclerosis</i> <i></i> <i></i> 148: 1 171-177<br/>

http://publicationslist.org/tetsuo.shoji/refid33 2008-04-10T04:01:47Z

Oxidation of LDLs plays an important role in atherosclerosis, and immune response to oxidized LDL (oxLDL) may modulate atherogenesis. Although immunization with oxLDL is shown to suppress atherogenesis in animal models, the role of the immune response to oxLDL is not well established in humans. We investigated the relationship between the titer of anti-oxLDL antibody (oxLDL Ab) and arterial wall t...<br/><br/>M Fukumoto, T Shoji, M Emoto, T Kawagishi, Y Okuno, Y Nishizawa (2000) <i>Arterioscler Thromb Vasc Biol</i> <i></i> <i></i> 20: 3 703-707<br/>

http://publicationslist.org/tetsuo.shoji/refid35 2008-04-10T04:01:47Z

Duplex Doppler sonography has been reported to be useful in examining the intrarenal hemodynamic abnormalities in various renal diseases. We investigated the impact of diabetes on intrarenal hemodynamics in patients with chronic renal failure (CRF). The resistive index and pulsatility index of the renal interlobar arteries were measured using duplex Doppler sonography in 90 CRF patients (serum cre...<br/><br/>N Matsumoto, E Ishimura, H Taniwaki, M Emoto, T Shoji, T Kawagishi, M Inaba, Y Nishizawa (2000) <i>Nephron</i> <i></i> <i></i> 86: 1 44-51<br/>

http://publicationslist.org/tetsuo.shoji/refid36 2008-04-10T04:01:47Z

T Shoji, E Kimoto, A Yamada, M Emoto, T Kawagishi, T Tabata, Y Nishizawa (2000) <i>Nephron</i> <i></i> <i></i> 86: 3 389-390<br/>

http://publicationslist.org/tetsuo.shoji/refid37 2008-04-10T04:01:47Z

T Shoji, T Kawagishi, M Emoto, K Maekawa, H Taniwaki, H Kanda, Y Nishizawa (2000) <i>Atherosclerosis</i> <i></i> <i></i> 153: 1 257-258<br/>

http://publicationslist.org/tetsuo.shoji/refid28 2008-04-10T04:01:47Z

BACKGROUND: Patients with chronic renal failure often have alterations in lipoprotein profile including elevated very-low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL), and reduced high density lipoprotein (HDL) levels. Among these changes, raised IDL has been shown as an independent risk factor for atherosclerosis in hemodialysis patients. There are a limited number of stu...<br/><br/>Y Nishizawa, T Shoji, T Tabata, T Inoue, H Morii (1999) <i>Kidney Int Suppl</i> <i></i> <i></i> 71: S134-S136<br/>

http://publicationslist.org/tetsuo.shoji/refid29 2008-04-10T04:01:47Z

OBJECTIVE: The aim of this study was to assess the relationship between atherotic (structural) and sclerotic (functional) changes in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Aortic distensibility and carotid intimal-media thickness (IMT) were evaluated using carotid-femoral aortic pulse-wave velocity (a-PWV) and high-resolution B-mode ultrasonography in 271 patients with type 2 ...<br/><br/>H Taniwaki, T Kawagishi, M Emoto, T Shoji, H Kanda, K Maekawa, Y Nishizawa, H Morii (1999) <i>Diabetes Care</i> <i></i> <i></i> 22: 11 1851-1857<br/>

http://publicationslist.org/tetsuo.shoji/refid27 2008-04-10T04:01:47Z

OBJECTIVE: To investigate whether the insulin resistance index (IR) assessed by homeostasis model assessment (HOMA) is associated with the insulin resistance index assessed by euglycemic-hyperinsulinemic clamp (clamp IR) in type 2 diabetic patients who received sulfonylureas (SUs), as well as in those treated by diet alone. RESEARCH DESIGN AND METHODS: Retrospectively, the association between HOMA...<br/><br/>M Emoto, Y Nishizawa, K Maekawa, Y Hiura, H Kanda, T Kawagishi, T Shoji, Y Okuno, H Morii (1999) <i>Diabetes Care</i> <i></i> <i></i> 22: 5 818-822<br/>

http://publicationslist.org/tetsuo.shoji/refid30 2008-04-10T04:01:47Z

OBJECTIVE: To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects. RESEARCH DESIGN AND METHODS: Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave velocity (a-PWV) and carotid stiffness beta using an echo-tracking system in 137 pati...<br/><br/>H Taniwaki, T Kawagishi, M Emoto, T Shoji, M Hosoi, K Kogawa, Y Nishizawa, H Morii (1999) <i>Diabetes Care</i> <i></i> <i></i> 22: 11 1858-1864<br/>

http://publicationslist.org/tetsuo.shoji/refid31 2008-04-10T04:01:47Z

The adipocyte-derived hormone leptin is the 16-kd product of the ob gene that regulates food intake and body weight. Plasma leptin level is elevated in patients with chronic renal failure, partly because of impaired clearance through the kidney. In this study, we examined whether leptin is cleared into peritoneal dialysate in patients with end-stage renal disease treated by continuous ambulatory p...<br/><br/>Y Tsujimoto, T Shoji, T Tabata, A Morita, M Emoto, Y Nishizawa, H Morii (1999) <i>Am J Kidney Dis</i> <i></i> <i></i> 34: 5 832-838<br/>

http://publicationslist.org/tetsuo.shoji/refid24 2008-04-10T04:01:47Z

Leptin is a newly found hormone secreted by adipocytes that regulates food intake, thermogenesis, and body fat. We measured plasma leptin levels in 103 patients with chronic renal failure treated by hemodialysis and 167 age- and gender-matched healthy control subjects to examine the impact of renal failure on plasma leptin levels and the influence of leptin on body composition measured by dual-ene...<br/><br/>Y Nishizawa, T Shoji, S Tanaka, M Yamashita, A Morita, M Emoto, T Tabata, T Inoue, H Morii (1998) <i>Am J Kidney Dis</i> <i></i> <i></i> 31: 4 655-661<br/>

http://publicationslist.org/tetsuo.shoji/refid23 2008-04-10T04:01:47Z

T Shoji, Y Nishizawa, T Kawagishi, M Emoto, H Morii (1998) <i>Nephron</i> <i></i> <i></i> 78: 1 121-122<br/>

http://publicationslist.org/tetsuo.shoji/refid25 2008-04-10T04:01:47Z

Patients with chronic renal failure often show accumulation of intermediate-density lipoprotein (IDL). Because recent studies have emphasized the atherogenicity of IDL in the general population, we evaluated the relationship between this lipoprotein and aortic atherosclerosis in uremic patients treated with hemodialysis. Aortic pulse wave velocity (PWV) was measured as a noninvasive index of scler...<br/><br/>T Shoji, Y Nishizawa, T Kawagishi, K Kawasaki, H Taniwaki, T Tabata, T Inoue, H Morii (1998) <i>J Am Soc Nephrol</i> <i></i> <i></i> 9: 7 1277-1284<br/>

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OBJECTIVE: To investigate the association between arterial wall stiffness indexes beta of the common carotid artery (CCA) and the femoral artery (FA) and insulin resistance in NIDDM subjects in a cross-sectional study. RESEARCH DESIGN AND METHODS: We evaluated the arterial stiffness indexes beta of CCA and FA using an ultrasonic phase-locked echo-tracking system in 60 NIDDM subjects attending the ...<br/><br/>M Emoto, Y Nishizawa, T Kawagishi, K Maekawa, Y Hiura, H Kanda, K Izumotani, T Shoji, E Ishimura, M Inaba, Y Okuno, H Morii (1998) <i>Diabetes Care</i> <i></i> <i></i> 21: 7 1178-1182<br/>

http://publicationslist.org/tetsuo.shoji/refid18 2008-04-10T04:01:47Z

T Shoji, Y Nishizawa, K Kawasaki, T Tabata, Y Matsushita, T Inoue, H Morii (1997) <i>Nephron</i> <i></i> <i></i> 77: 1 112-113<br/>

http://publicationslist.org/tetsuo.shoji/refid19 2008-04-10T04:01:47Z

We examined the association between the polymorphism of the apolipoprotein E (apoE) and the ACE genes and the intima-media thickness (IMT) of the carotid and femoral arteries measured using ultrasonography. The values of IMT of each artery were significantly higher in NIDDM patients (n = 356) than in control subjects (n = 235). The E4 allele or the D allele did not affect clinical characteristics,...<br/><br/>K Kogawa, Y Nishizawa, M Hosoi, T Kawagishi, K Maekawa, T Shoji, Y Okuno, H Morii (1997) <i>Diabetes</i> <i></i> <i></i> 46: 4 682-687<br/>

http://publicationslist.org/tetsuo.shoji/refid17 2008-04-10T04:01:47Z

E Ishimura, Y Nishizawa, M Emoto, T Shoji, M Inaba, T Kawagishi, H Morii (1997) <i>Nephron</i> <i></i> <i></i> 76: 2 227-229<br/>

http://publicationslist.org/tetsuo.shoji/refid20 2008-04-10T04:01:47Z

We compared plasma lipid and lipoprotein parameters between 210 chronic renal failure patients treated by hemodialysis and 223 age- and sex-matched healthy control subjects to examine whether atherogenic lipoprotein changes were present in hemodialysis patients in the absence of hyperlipidemia. The hemodialysis group showed higher levels of plasma triglycerides, very low density lipoprotein (VLDL)...<br/><br/>T Shoji, Y Nishizawa, T Kawagishi, M Tanaka, K Kawasaki, T Tabata, T Inoue, H Morii (1997) <i>Atherosclerosis</i> <i></i> <i></i> 131: 2 229-236<br/>

http://publicationslist.org/tetsuo.shoji/refid22 2008-04-10T04:01:47Z

Cardiovascular motality is high in patients with chronic renal failure treated with dialysis, and secondary hyperparathyroidism may promote atherosclerogenesis. Recent studies have revealed advanced atherosclerosis in hemodialysis patients by using high-resolution B-mode ultrasonography. Multiple regression analyses indicated that hyperphosphatemia and hyperparathyroidism were associated with incr...<br/><br/>Y Nishizawa, T Shoji, T Kawagishi, H Morii (1997) <i>Kidney Int Suppl</i> <i></i> <i></i> 62: S90-S92<br/>

http://publicationslist.org/tetsuo.shoji/refid21 2008-04-10T04:01:47Z

Plasma leptin level is known to correlate with the degree of obesity. To determine the influences of renal function and insulin resistance on plasma leptin concentrations, we measured plasma leptin concentrations and performed the euglycaemic hyperinsulinaemic clamp studies in 57 patients with non-insulin-dependent diabetes mellitus with a wide range of renal function. In simple regression analyse...<br/><br/>T Shoji, Y Nishizawa, M Emoto, K Maekawa, Y Hiura, S Tanaka, T Kawagishi, Y Okuno, H Morii (1997) <i>Diabetologia</i> <i></i> <i></i> 40: 6 676-679<br/>

http://publicationslist.org/tetsuo.shoji/refid16 2008-04-10T04:01:47Z

BACKGROUND: The insertion/deletion (I/D) polymorphism of the ACE gene has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with non-insulin-dependent diabetes mellitus (NIDDM). We investigated the relationship between the ACE gene polymorphism and the wall thickness of both carotid and femoral arteries in NIDDM patients. METHODS AND RESULTS: We mea...<br/><br/>M Hosoi, Y Nishizawa, K Kogawa, T Kawagishi, T Konishi, K Maekawa, M Emoto, S Fukumoto, A Shioi, T Shoji, M Inaba, Y Okuno, H Morii (1996) <i>Circulation</i> <i></i> <i></i> 94: 4 704-707<br/>

http://publicationslist.org/tetsuo.shoji/refid14 2008-04-10T04:01:47Z

Elevated plasma intermediate density lipoprotein (IDL) is one of the features of uremic dyslipidemia which is potentially atherogenic. We examined the effects of pravastatin, an HMG-CoA reductase inhibitor, on IDL levels as well as other lipoprotein parameters in 19 uremic patients treated with hemodialysis (HD, n = 11) or continuous ambulatory peritoneal dialysis (CAPD, n = 8). The patients were ...<br/><br/>Y Nishizawa, T Shoji, M Emoto, K Kawasaki, T Konishi, T Tabata, T Inoue, H Morii (1995) <i>Clin Nephrol</i> <i></i> <i></i> 43: 4 268-277<br/>

http://publicationslist.org/tetsuo.shoji/refid15 2008-04-10T04:01:47Z

We sought to determine whether artherosclerosis may be accelerated in uremic patients on maintenance hemodialysis and investigated the risk factors for carotid and femoral atherosclerosis in such patients. High-resolution B-mode ultrasonography was used to determine the intima-media thickness (IMT) of the carotid and femoral arteries in 199 hemodialysis patients and 81 age-matched healthy controls...<br/><br/>T Kawagishi, Y Nishizawa, T Konishi, K Kawasaki, M Emoto, T Shoji, T Tabata, T Inoue, H Morii (1995) <i>Kidney Int</i> <i></i> <i></i> 48: 3 820-826<br/>

http://publicationslist.org/tetsuo.shoji/refid13 2008-04-10T04:01:47Z

We examined the effects of a fibric acid, clinofibrate, on lipoprotein metabolism in 12 hyperlipidemic patients with uremia treated on continuous ambulatory peritoneal dialysis during a 24 week treatment. Daily dose of clinofibrate was 200 mg for the initial four weeks, 400 mg for the second four weeks, and 600 mg for the subsequent 16 weeks. Serum and very-low density lipoprotein (VLDL) triglycer...<br/><br/>Y Nishizawa, T Shoji, H Nishitani, M Yamakawa, T Konishi, K Kawasaki, H Morii (1993) <i>Kidney Int</i> <i></i> <i></i> 44: 6 1352-1359<br/>

http://publicationslist.org/tetsuo.shoji/refid9 2008-04-10T04:01:47Z

We measured lipoproteins, apolipoproteins, lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL), lecithin: cholesterol acyltransferase (LCAT) and parameters of calcium metabolism to evaluate the roles of these enzymes and hypertriglyceridemia for impaired high-density lipoprotein (HDL) metabolism in chronic renal failure, and to examine the impact of altered calcium homeostasis on the lipo...<br/><br/>T Shoji, Y Nishizawa, H Nishitani, M Yamakawa, H Morii (1992) <i>Kidney Int</i> <i></i> <i></i> 41: 6 1653-1661<br/>

http://publicationslist.org/tetsuo.shoji/refid8 2008-04-10T04:01:47Z

1,5-Anhydro-D-glucitol (AG) is one of the main polyols and its structure resembles glucose. It has been proposed that decreased serum AG concentrations in diabetic patients are a novel indicator of diabetic metabolic derangement. However, the pathway of AG metabolism still remains to be clarified. In this study we investigated the transport of AG into human polymorphonuclear leukocytes (PMNLs) iso...<br/><br/>Y Okuno, Y Nishizawa, T Kawagishi, K Sekiya, T Shoji, H Morii (1992) <i>J Biochem</i> <i></i> <i></i> 111: 1 99-102<br/>

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Calcium homeostasis during a very-low-calorie diet (VLCD) was examined. During the treatment, intact parathyroid hormone tended to decrease initially, bone Gla-protein increased significantly in the third week, and tartrate-resistant acid phosphatase decreased during the entire treatment. Serum ketone bodies showed significant correlations with intact parathyroid hormone and bone Gla-protein in so...<br/><br/>Y Nishizawa, H Koyama, T Shoji, H Tahara, S Hagiwara, H Aratani, K Nakatsuka, T Miki, H Morii (1992) <i>Am J Clin Nutr</i> <i></i> <i></i> 56: 1 Suppl 265S-267S<br/>

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We examined the changes in high-density-lipoprotein (HDL) metabolism in eight female obese patients undergoing a very-low-calorie diet (VLCD). In the first half of the study, HDL cholesterol (HDL-C), apolipoprotein A-I (apo A-I), and apo A-II showed a parallel decrease. Although lipoprotein lipase (LPL) and hepatic lipase (HTGL) did not change, lecithin: cholesterol acyltransferase (LCAT) decrease...<br/><br/>T Shoji, Y Nishizawa, H Koyama, S Hagiwara, H Aratani, K Sasao, H Kishimoto, H Tanishita, H Morii (1992) <i>Am J Clin Nutr</i> <i></i> <i></i> 56: 1 Suppl 297S-298S<br/>

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We measured serum lipoprotein(a) [Lp (a)] concentrations in 50 uremic patients treated on continuous ambulatory peritoneal dialysis (CAPD) and compared them with those in 29 uremic patients on hemodialysis (HD) and those in 62 normal controls. The median values were 47.9 mg/dl in CAPD patients, 25.2 mg/dl in HD patients, and 11.7 mg/dl in controls, respectively. These differences were statisticall...<br/><br/>T Shoji, Y Nishizawa, H Nishitani, M Yamakawa, H Morii (1992) <i>Clin Nephrol</i> <i></i> <i></i> 38: 5 271-276<br/>

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Direct effects of human uremic serum on the production of endothelin-1 in cultured porcine endothelial cells were examined in this study. Uremic serum decreased the level of monomeric endothelin-1 secreted into the culture medium by endothelial cells. This effect occurred at a transcriptional step because uremic serum decreased the endothelin-1 mRNA level in those cells. For the partial characteri...<br/><br/>H Koyama, H Tahara, T Shoji, Y Nishizawa, M Inaba, S Otani, M Yanagisawa, Y Ishiguro, N Takanashi, H Morii (1991) <i>Contrib Nephrol</i> <i></i> <i></i> 90: 111-115<br/>

http://publicationslist.org/tetsuo.shoji/refid3 2008-04-10T04:01:47Z

T Shoji, Y Nishizawa, A Toyokawa, T Kawagishi, Y Okuno, H Morii (1991) <i>Nephron</i> <i></i> <i></i> 59: 4 664-665<br/>

http://publicationslist.org/tetsuo.shoji/refid5 2008-04-10T04:01:47Z

To assess the mechanism of serum lipoprotein abnormalities in continuous ambulatory peritoneal dialysis (CAPD), we measured serum lipids, apolipoproteins, and postheparin lipases in 46 patients with end-stage renal disease (ESRD) treated on CAPD, 26 patients on hemodialysis (HD), and 29 healthy subjects. HD patients had higher serum triglyceride levels than the healthy controls, showing type IV an...<br/><br/>T Shoji, Y Nishizawa, H Nishitani, M Yamakawa, H Morii (1991) <i>Metabolism</i> <i></i> <i></i> 40: 10 1002-1008<br/>

http://publicationslist.org/tetsuo.shoji/refid6 2008-04-10T04:01:47Z

We examined changes in high density lipoprotein (HDL) metabolism during a very low calorie diet weight reduction program in 6 massively obese normolipidemic women. The diet protocol consisted of a 1st low calorie diet (LCD; 1440, 1280, and 880 kcal daily for 1 week, each, in succession), a 1st very low calorie diet (VLCD; 420 kcal daily for 4 weeks, using Optifast 70), intermission (880 kcal daily...<br/><br/>T Shoji, Y Nishizawa, H Koyama, S Hagiwara, H Aratani, K Izumotani-Sasao, H Kishimoto, H Tanishita, H Morii (1991) <i>J Nutr Sci Vitaminol (Tokyo)</i> <i></i> <i></i> 37 Suppl: S57-S64<br/>

http://publicationslist.org/tetsuo.shoji/refid7 2008-04-10T04:01:47Z

Total body and regional bone mineral density (BMD) and bone mineral content (BMC) in obese patients and healthy controls were assessed by dual-photon absorptiometry (DPA) in this study. In both men and women, BMD values in total body, pelvis, upper and lower extremities were significantly (p less than 0.05) higher in the obese group (body mass index greater than 28) than in the non-obese group (bo...<br/><br/>Y Nishizawa, H Koyama, T Shoji, H Aratani, S Hagiwara, T Miki, H Morii (1991) <i>J Nutr Sci Vitaminol (Tokyo)</i> <i></i> <i></i> 37 Suppl: S65-S70<br/>

http://publicationslist.org/tetsuo.shoji/refid2 2008-04-10T04:01:47Z

Serum fructosamine levels were investigated in patients with uremia undergoing various modes of treatment. The serum fructosamine levels correlated positively with the blood glucose levels determined a week or two earlier. The fructosamine levels were significantly affected by the protein concentration, and those corrected for protein concentrations had a closer correlation to the blood glucose le...<br/><br/>T Shoji, T Tabata, Y Nishizawa, K Kikunami, Y Matsushita, T Inoue, M Kenmotsu, T Miki, H Morii (1989) <i>Nephron</i> <i></i> <i></i> 51: 3 338-343<br/>

http://publicationslist.org/tetsuo.shoji/refid1 2008-04-10T04:01:47Z

The immunoregulatory effect of 1 alpha-OHD3, a precursor form of active vitamin D3 1,25 (OH)2D3, was examined in hemodialysis patients. Peripheral blood mononuclear cells (PBM) from hemodialysis patients produced significantly less interleukin-2 (IL-2) than those from normal controls. Four weeks of oral administration of 0.5 micrograms/day of 1 alpha-OHD3 enhanced the IL-2 production of PBM from t...<br/><br/>T Tabata, T Shoji, K Kikunami, Y Matsushita, T Inoue, S Tanaka, M Hino, T Miki, Y Nishizawa, H Morii (1988) <i>Nephron</i> <i></i> <i></i> 50: 4 295-298<br/>