http://publicationslist.org/data/thierry.lorca/atom.xml Thierry lorcahttp://publicationslist.org/thierry.lorca$basepathfavicon.icoRecent additions to Thierry lorca's PublicationsList.org pagehttp://publicationslist.org/publications.png2009-04-20T12:22:29Z http://publicationslist.org/thierry.lorca/refid1 2009-04-20T12:22:12Z

Chfr is a checkpoint protein that plays an important function in cell cycle progression and tumor suppression, although its exact role and regulation are unclear. Previous studies have utilized overexpression of Chfr to determine the signaling pathway of this protein in vivo. In this study, we demonstrate, by using three different antibodies against Chfr, that the endogenous and highly overexpress...<br/><br/> Burgess, Labbé, Vigneron, Bonneaud, Strub, Van Dorsselaer, Lorca, Castro (2008) <i>Oncogene</i> <i></i> <i></i> : <br/>

http://publicationslist.org/thierry.lorca/refid2 2009-04-20T12:22:12Z

The anaphase-promoting complex (APC) early mitotic inhibitor 1 (Emi1) is required to induce S- and M-phase entries by stimulating the accumulation of cyclin A and cyclin B through APC(Cdh1/cdc20) inhibition. In this report, we show that Emi1 proteolysis can be induced by cyclin A/cdk (cdk for cyclin-dependent kinase). Paradoxically, Emi1 is stable during G2 phase, when cyclin A/cdk, Plx1 and SCF(b...<br/><br/>Cyril Bernis, Suzanne Vigneron, Andrew Burgess, Jean-Claude Labbé, Didier Fesquet, Anna Castro, Thierry Lorca (2007) <i>EMBO Rep</i> <i></i> <i></i> 8: 1 91-98<br/>

http://publicationslist.org/thierry.lorca/refid5 2009-04-20T12:22:12Z

Events controlling cell division are governed by the degradation of different regulatory proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation. Xenopus egg extracts present many advantages for the study of the cell cycle, including the availability of a large quantity of mat...<br/><br/>Anna Castro, Suzanne Vigneron, Cyril Bernis, Jean-Claude Labbé, Thierry Lorca (2006) <i>Methods Mol Biol</i> <i></i> <i></i> 322: 223-234<br/>

http://publicationslist.org/thierry.lorca/refid3 2009-04-20T12:22:12Z

The transcription factors MyoD and Myf5 present distinct patterns of expression during cell cycle progression and development. In contrast to the mitosis-specific disappearance of Myf5, which requires a D-box-like motif overlapping the basic domain, here we describe a stable and inactive mitotic form of MyoD phosphorylated on its serine 5 and serine 200 residues by cyclin B-cdc2. In mitosis, these...<br/><br/>Sabrina Batonnet-Pichon, Lionel J Tintignac, Anna Castro, Valentina Sirri, Marie Pierre Leibovitch, Thierry Lorca, Serge A Leibovitch (2006) <i>Exp Cell Res</i> <i></i> <i></i> 312: 20 3999-4010<br/>

http://publicationslist.org/thierry.lorca/refid7 2009-04-20T12:22:12Z

Although the role of the b-cell lymphoma (Bcl)-2 family of apoptosis inhibitors is well documented in tumor cells and tissue morphogenesis, their role during the early development of vertebrates is unknown. Here, we characterize Nrz, a new Bcl-2-related inhibitor of apoptosis in zebrafish. Nrz is a mitochondrial protein, antagonizing the death-accelerator Bax. The nrz gene is mainly expressed duri...<br/><br/>E Arnaud, K F Ferri, J Thibaut, Z Haftek-Terreau, A Aouacheria, D Le Guellec, T Lorca, G Gillet (2006) <i>Cell Death Differ</i> <i></i> <i></i> 13: 7 1128-1137<br/>

http://publicationslist.org/thierry.lorca/refid4 2009-04-20T12:22:12Z

Xenopus RINGO/Speedy (XRINGO) is a potent inducer of oocyte meiotic maturation that can directly activate Cdk1 and Cdk2. Here, we show that endogenous XRINGO protein accumulates transiently during meiosis I entry and then is downregulated. This tight regulation of XRINGO expression is the consequence of two interconnected mechanisms: processing and degradation. XRINGO processing involves recogniti...<br/><br/>Gustavo J Gutierrez, Andrea Vögtlin, Ana Castro, Ingvar Ferby, Giorgia Salvagiotto, Ze'ev Ronai, Thierry Lorca, Angel R Nebreda (2006) <i>Nat Cell Biol</i> <i></i> <i></i> 8: 10 1084-1094<br/>

http://publicationslist.org/thierry.lorca/refid6 2009-04-20T12:22:12Z

BACKGROUND: The two myogenic regulatory factors Myf5 and MyoD are basic helix-loop-helix muscle transcription factors undergoing differential cell cycle dependent proteolysis in proliferating myoblasts. This regulated degradation results in the striking expression of these two factors at distinct phases of the cell cycle, and suggests that their precise and alternated disappearance is an important...<br/><br/>Christine Doucet, Gustavo J Gutierrez, Catherine Lindon, Thierry Lorca, Gwendaline Lledo, Christian Pinset, Olivier Coux (2005) <i>BMC Biochem</i> <i></i> <i></i> 6: <br/>

http://publicationslist.org/thierry.lorca/refid9 2009-04-20T12:22:12Z

The success of cell division relies on the activation of its master regulator Cdc2-cyclin B, and many other kinases controlling cellular organization, such as Aurora-A. Most of these kinase activities are regulated by phosphorylation. Despite numerous studies showing that okadaic acid-sensitive phosphatases regulate both Cdc2 and Aurora-A activation, their identity has not yet been established in ...<br/><br/>Gilliane Maton, Thierry Lorca, Jean-Antoine Girault, René Ozon, Catherine Jessus (2005) <i>J Cell Sci</i> <i></i> <i></i> 118: Pt 11 2485-2494<br/>

http://publicationslist.org/thierry.lorca/refid8 2009-04-20T12:22:12Z

Anna Castro, Thierry Lorca (2005) <i>EMBO Rep</i> <i></i> <i></i> 6: 9 821-825<br/>

http://publicationslist.org/thierry.lorca/refid10 2009-04-20T12:22:12Z

Events controlling cell division are governed by the degradation of different regulatory proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation by the 26S proteasome. Two different ubiquitin ligases play an important role in the cell cycle: the SCF (Skp1/Cullin/F-box) and the...<br/><br/>Anna Castro, Cyril Bernis, Suzanne Vigneron, Jean-Claude Labbé, Thierry Lorca (2005) <i>Oncogene</i> <i></i> <i></i> 24: 3 314-325<br/>