http://publicationslist.org/data/tobias.nef/atom.xml Gerontechnology & Rehabilitation Group //publicationslist.org/tobias.nef$basepathfavicon.icoRecent additions to Gerontechnology & Rehabilitation Group 's PublicationsList.org page//publicationslist.org/publications.png2026-04-30T05:56:25Z //publicationslist.org/tobias.nef/refid637 2026-04-30T05:51:29Z

Despina Zlatkova, Stephan M Gerber, Branislav Savic, Tobias Nef, Adrian G Guggisberg, Marija Uscumlic (2026) <i>Brain topography</i> <i></i> <i></i> 39: 4 <br/>

//publicationslist.org/tobias.nef/refid638 2026-04-30T05:51:57Z

Pareidolia-the perception of illusory patterns such as faces or objects in ambiguous stimuli-has been extensively studied, but less is known about how different visual environments shape this phenomenon. This study investigated pareidolia experienced in unmodified natural images (NI) and white noise (WN) images in 81 healthy participants under open-ended instructions. Across both conditions, anima...<br/><br/>N Göbel, M Camenzind, T Nef, U P Mosimann, R M Müri, A K Eberhard-Moscicka (2026) <i>Scientific reports</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid633 2026-02-25T15:16:30Z

α-band-mediated brain network communication underlies visual processing and is disrupted in visual deficits. We aimed to develop and evaluate an EEG-based neurofeedback targeting α-band connectivity of source-reconstructed visual areas with the rest of the brain, to determine whether modulating this network enhances detection of low-contrast visual stimuli. In this randomized, active-controlled ...<br/><br/>Despina Zlatkova, Stephan M Gerber, Branislav Savic, Tobias Nef, Adrian G Guggisberg, Marija Ušćumlić (2026) <i>Brain topography</i> <i></i> <i></i> 39: 2 <br/>

//publicationslist.org/tobias.nef/refid639 2026-04-30T05:52:50Z

Post-stroke fatigue (PSF) is common and impacts stroke rehabilitation. Dopaminergic treatment may have beneficial effects on PSF. This study investigated whether levodopa, compared with placebo, was associated with a lower frequency or severity of PSF during in-hospital rehabilitation.<br/><br/>Lukas Boos, Josefin E Kaufmann, Mirjam I Sauter, Philippe Lyrer, Annaelle Zietz, Simon Trüssel, Sophia V Engelter, Andreas R Luft, Alexandros Polymeris, Valerian L Altersberger, Karin Wiesner, Jeremia P O Held, Yannik Rottenberger, Anne Schwarz, Friedrich Medlin, Ettore A Accolla, Sandrine Foucras, Georg Kägi, Gian Marco De Marchis, Svetlana Politz, Matthias Greulich, Alexander A Tarnutzer, Rolf Sturzenegger, Mira Katan, Urs Fischer, Krassen Nedeltchev, Janine Schär, Katrien Van Den Keybus Deglon, Pierre-André Rapin, Alexander Salerno, David Seiffge, Elias Auer, Julian Lippert, Leo H Bonati, Corina Schuster-Amft, Szabina Gäumann, Joelle N Chabwine, Andrea M Humm, Jens Carsten Möller, Raoul Schweinfurther, Bartosz Bujan, Piotr Jedrysiak, Peter S Sandor, Roman Gonzenbach, Mylius Veit, Dietmar Lutz, Carmen Lienert, Nils Peters, Davide Strambo, René M Müri, Sabine Schädelin, Lars G Hemkens, Gary A Ford, Anna Kuppuswamy, Anners Lerdal, Dawn B Simpson, Coralie English, Stewart Blackwell, Henrik Gensicke, Christopher Traenka, Stefan T Engelter (2026) <i>European stroke journal</i> <i></i> <i></i> 11: 4 <br/>

//publicationslist.org/tobias.nef/refid641 2026-04-30T05:53:24Z

Post-stroke depression (PSD) frequently occurs after acute stroke and negatively affects rehabilitation. Dopamine has beneficial effects on motivation and emotional stability. In stroke patients, low dopamine levels are linked to PSD. This study investigated whether levodopa treatment during in-hospital rehabilitation impacts PSD compared to placebo.<br/><br/>Mirjam I Sauter, Josefin E Kaufmann, Lukas Boos, Annaelle Zietz, Simon Trüssel, Andreas R Luft, Alexandros Polymeris, Valerian L Altersberger, Karin Wiesner, Martina Wiegert, Jeremia P O Held, Yannik Rottenberger, Anne Schwarz, Friedrich Medlin, Ettore A Accolla, Sandrine Foucras, Georg Kägi, Gian Marco De Marchis, Svetlana Politz, Matthias Greulich, Alexander A Tarnutzer, Rolf Sturzenegger, Mira Katan, Marcel Arnold, Krassen Nedeltchev, Janine Schär, Katrien Van Den Keybus Deglon, Pierre-André Rapin, Alexander Salerno, David J Seiffge, Elias Auer, Julian Lippert, Leo H Bonati, Corina Schuster-Amft, Szabina Gäumann, Joelle N Chabwine, Andrea Humm, J Carsten Möller, Raoul Schweinfurther, Bartosz Bujan, Piotr Jedrysiak, Peter S Sandor, Roman Gonzenbach, Veit Mylius, Dietmar Lutz, Carmen Lienert, Nils Peters, Patrik Michel, René M Müri, Sabine Schädelin, Lars G Hemkens, Gary A Ford, Philippe A Lyrer, Henrik Gensicke, Christopher Traenka, Stefan T Engelter (2026) <i>European stroke journal</i> <i></i> <i></i> 11: 2 <br/>

//publicationslist.org/tobias.nef/refid630 2025-05-08T14:27:07Z

Aortic stenosis is a progressive condition with a grim prognosis, underscoring the importance of timely intervention to prevent decompensation. Home monitoring systems, particularly those utilizing ambient sensors, offer promise in detecting early signs of deterioration.<br/><br/>Nisha Arenja, Narayan Schütz, Philipp Buluschek, Tobias Nef, Hugo Saner (2025) <i>European heart journal. Case reports</i> <i></i> <i></i> 9: 2 <br/>

//publicationslist.org/tobias.nef/refid632 2025-05-08T14:27:56Z

Impulse control disorders (ICD) are common side effects of dopaminergic treatment in Parkinson's disease (PD). Whereas some studies show a reduction in ICD after subthalamic nucleus deep brain stimulation (STN-DBS), others report worsening of ICD or impulsivity.<br/><br/>Deborah Amstutz, Katrin Petermann, Mario Sousa, Ines Debove, Marie Elise Maradan-Gachet, Lena C Bruhin, Andreia D Magalhães, Gerd Tinkhauser, Andreas Diamantaras, Julia Waskönig, Lenard Martin Lachenmayer, Claudio Pollo, Dario Cazzoli, Tobias Nef, Masud Husain, Paul Krack (2025) <i>Movement disorders clinical practice</i> <i></i> <i></i> 12: 4 484-496<br/>

//publicationslist.org/tobias.nef/refid631 2025-05-08T14:27:31Z

Effects of subthalamic nucleus deep brain stimulation (STN-DBS) on neuropsychiatric symptoms of Parkinson's disease (PD) remain debated. Sensor technology might help to objectively assess behavioural changes after STN-DBS.<br/><br/>Lena C Bruhin, Michael Single, Aileen C Naef, Katrin Petermann, Mario Sousa, Matilde Castelli, Ines Debove, Marie E Maradan-Gachet, Andreia D Magalhães, Andreas A Diamantaras, M Lenard Lachenmayer, Gerd Tinkhauser, Julia Waskönig, Christopher M El Achkar, Alia Lemkaddem, Mathieu Lemay, Paul Krack, Tobias Nef, Deborah Amstutz (2025) <i>BMC neurology</i> <i></i> <i></i> 25: 1 <br/>

//publicationslist.org/tobias.nef/refid629 2025-05-08T14:26:37Z

This pilot study aimed to evaluate the usability of a new, feedback-based dexterity training system in people with Parkinson's disease (PwPD) and healthy adults. Seven PwPD and seven healthy adults participated in the study. The System Usability Scale (SUS) and the Post-Study System Usability Questionnaire Version 3 (PSSUQ) were used to assess usability. Additionally, the feedback shown as a count...<br/><br/>Nic Krummenacher, Stephan M Gerber, Manuela Pastore-Wapp, Michael Single, Stephan Bohlhalter, Tobias Nef, Tim Vanbellingen (2025) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 25: 4 <br/>

//publicationslist.org/tobias.nef/refid623 2025-05-08T14:24:28Z

Over the past decade, neuropsychiatric fluctuations in Parkinson's disease (PD) have been increasingly recognized for their impact on patients' quality of life. Speech, a complex function carrying motor, emotional, and cognitive information, offers potential insights into these fluctuations. While previous studies have focused on acoustic analysis to assess motor speech disorders reliably, the pot...<br/><br/>Matilde Castelli, Mario Sousa, Illner Vojtech, Michael Single, Deborah Amstutz, Marie Elise Maradan-Gachet, Andreia D Magalhães, Ines Debove, Jan Rusz, Pablo Martinez-Martin, Raphael Sznitman, Paul Krack, Tobias Nef (2025) <i>NPJ Parkinson's disease</i> <i></i> <i></i> 11: 1 <br/>

//publicationslist.org/tobias.nef/refid625 2025-05-08T14:25:01Z

Sensor-based surveillance technology (SST) is increasingly employed in the care of people with dementia (PwD) in hospitals, nursing homes, and home care. With improved functionality and availability of SST, there will likely be a growing utilization in clinical settings. In the context of staff shortage, the expected resource-efficient safety benefits are attractive but must be critically balanced...<br/><br/>Jacob Lahr, Nicole Schulze, Larissa N Wüst, Claus Beisbart, Lena C Bruhin, Marcello Ienca, Tobias Nef, Manuel Trachsel, Stefan Klöppel (2025) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 25: 7 <br/>

//publicationslist.org/tobias.nef/refid627 2026-02-25T15:16:30Z

Auditory motion stimulation is a promising new therapeutical approach for visual neglect, whereby patients listen to music which repeatedly moves from the ipsi - to the contralateral hemispace. In this study, we investigated the feasibility, enjoyability, and efficacy of auditory motion simulation in an inpatient neurorehabilitation setting. 30 patients with left-sided visual neglect due to a righ...<br/><br/>Nora Geiser, Brigitte C Kaufmann, Dario Cazzoli, Tobias Nef, Thomas Nyffeler (2025) <i>Neuropsychological rehabilitation</i> <i></i> <i></i> 35: 10 1903-1917<br/>

//publicationslist.org/tobias.nef/refid628 2026-02-25T15:17:15Z

Novel commercial brain-sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real-life ambulatory settings in Parkinson's disease (PD). Although various candidate biomarkers have been proposed for adaptive deep brain stimulation (DBS), a comprehensive comparison of their ambulatory profiles is lacking.<br/><br/>Aaron Colombo, Elena Bernasconi, Laura Alva, Mario Sousa, Ines Debove, Andreas Nowacki, Camille Serquet, Katrin Petermann, T A Khoa Nguyen, Andreia D Magalhães, Lenard Lachenmayer, Julia Waskönig, Tobias Nef, Michael Schuepbach, Claudio Pollo, Paul Krack, Alberto Averna, Gerd Tinkhauser (2025) <i>Movement disorders : official journal of the Movement Disorder Society</i> <i></i> <i></i> 40: 5 881-895<br/>

//publicationslist.org/tobias.nef/refid626 2025-05-08T14:25:01Z

Patients with postural tachycardia syndrome report position-dependent visual symptoms. Despite their impact on daily life, these symptoms have remained largely unexplored in research. The aim of this study was to investigate the nature of visual symptoms in postural tachycardia syndrome and possible underlying pathophysiological mechanisms.<br/><br/>Belén Rodriguez, Lynn Pantano, Tobias Nef, René M Müri, Werner J Z'Graggen (2025) <i>European journal of neurology</i> <i></i> <i></i> 32: 1 <br/>

//publicationslist.org/tobias.nef/refid644 2026-04-30T05:55:15Z

The thalamus plays a key role in motor and sensory processes of the brain. Though thalamic stroke is among the less frequent, even a minimal lesion can result in a serious impairment and long-lasting disability. After thalamic stroke, cases of dysexecutive syndrome and so-called diencephalic amnesia have been observed, yet the precise characterisation or categorisation of such amnestic syndrome is...<br/><br/>Jakub Grulich, Elisabeth Lösken, René M Müri (2025) <i>BMC neurology</i> <i></i> <i></i> 25: 1 <br/>

//publicationslist.org/tobias.nef/refid634 2026-02-25T15:16:30Z

The sense of one's own body, also referred to as bodily self-consciousness (BSC), is an important aspect of self-consciousness, that allows us to experience our body as our own. Previous research has identified the distinct components of BSC (i.e., body ownership, sense of agency, and self-location), and investigated their neural correlates separately. However, a consensus on the brain regions inv...<br/><br/>Nicola Brunello, Lorenzo Diana, Jothini Sritharan, Marija Glisic, Tobias Nef, Rajeev K Verma, Giuseppe A Zito (2025) <i>Neuroscience and biobehavioral reviews</i> <i></i> <i></i> 179: <br/>

//publicationslist.org/tobias.nef/refid642 2026-04-30T05:54:01Z

Random noise stimulation (tRNS) applied to the dorsolateral prefrontal cortex (DLPFC) enhances fluency and originality in verbal divergent thinking tasks. However, the underlying neural mechanisms of this behavioral change remain unclear. Given that the DLPFC is a key node of the executive control network (ECN) and that creativity is a two-stage process in which the ECN is primarily involved in th...<br/><br/>Magdalena Camenzind, Rahel A Steuri, Branislav Savic, Fred W Mast, René M Müri, Aleksandra K Eberhard-Moscicka (2025) <i>Network neuroscience (Cambridge, Mass.)</i> <i></i> <i></i> 9: 2 569-590<br/>

//publicationslist.org/tobias.nef/refid643 2026-04-30T05:54:44Z

Parkinson's disease (PD) encompasses motor (e.g., bradykinesia) and non-motor (e.g., apathy) symptoms.<br/><br/>Fabian Rey, Damien Benis, Radek Ptak, Diego Kaski, Matthieu Béreau, René M Müri, Paul Krack, André Zacharia (2025) <i>Journal of neurology</i> <i></i> <i></i> 272: 3 <br/>

//publicationslist.org/tobias.nef/refid635 2026-02-25T15:17:15Z

Hemispatial neglect affects approximately 33% of patients after acute stroke and is linked to poor recovery. Auditory motion stimulation, particularly using spatial cues, can enhance spatial awareness and has shown promise in experimental settings.<br/><br/>Tobias Nef, Nora Geiser, Brigitte C Kaufmann, Noora Emilia Angelva, Nic Krummenacher, Michael Single, Dario Cazzoli, Thomas Nyffeler (2025) <i>Journal of medical Internet research</i> <i></i> <i></i> 27: <br/>

//publicationslist.org/tobias.nef/refid640 2026-04-30T05:52:50Z

Levodopa enhances dopaminergic signaling and may stimulate neuroplasticity, which could potentially enhance motor recovery after stroke. Levodopa is used in stroke rehabilitation despite mixed evidence for its effectiveness.<br/><br/>Stefan T Engelter, Josefin E Kaufmann, Annaelle Zietz, Andreas R Luft, Alexandros Polymeris, Valerian L Altersberger, Karin Wiesner, Martina Wiegert, Jeremia P O Held, Yannik Rottenberger, Anne Schwarz, Friedrich Medlin, Ettore A Accolla, Sandrine Foucras, Georg Kägi, Gian Marco De Marchis, Svetlana Politz, Matthias Greulich, Alexander A Tarnutzer, Rolf Sturzenegger, Mira Katan, Urs Fischer, Krassen Nedeltchev, Janine Schär, Katrien Van Den Keybus Deglon, Pierre-André Rapin, Alexander Salerno, David J Seiffge, Elias Auer, Julian Lippert, Leo H Bonati, Corina Schuster-Amft, Szabina Gäumann, Joelle N Chabwine, Andrea Humm, J Carsten Möller, Raoul Schweinfurther, Bartosz Bujan, Piotr Jedrysiak, Peter S Sandor, Roman Gonzenbach, Veit Mylius, Dietmar Lutz, Carmen Lienert, Nils Peters, Patrik Michel, René M Müri, Sabine Schädelin, Lars G Hemkens, Gary A Ford, Philippe A Lyrer, Henrik Gensicke, Christopher Traenka, (2025) <i>JAMA</i> <i></i> <i></i> 334: 17 1523-1532<br/>

//publicationslist.org/tobias.nef/refid636 2026-02-25T15:18:00Z

Speech abnormalities in Parkinson's disease (PD) are heterogeneous and often considered resistant to levodopa. However, human hearing may miss subtle treatment-related speech changes. Digital speech biomarkers offer a sensitive alternative to measure such changes objectively. Speech was recorded in 51 PD patients during ON and OFF medication states and compared to 43 healthy controls matched for l...<br/><br/>M Sousa, P Krýže, D Amstutz, K Petermann, A Averna, M Castelli, A D Magalhães, A Jorge, J Švihlík, T Tykalová, V Illner, M E Maradan-Gachet, A A Diamantaras, J Waskönig, M L Lachenmayer, I Debove, G Tinkhauser, T Nef, J Rusz, P Krack (2025) <i>NPJ Parkinson's disease</i> <i></i> <i></i> 11: 1 <br/>

//publicationslist.org/tobias.nef/refid646 2026-04-30T05:56:17Z

Novel therapeutic approaches are needed in stroke recovery. Whether pharmacological therapies are beneficial for enhancing stroke recovery is unclear. Dopamine is a neurotransmitter involved in motor learning, reward, and brain plasticity. Its prodrug levodopa is a promising agent for stroke recovery.<br/><br/>Annaelle Zietz, Josefin E Kaufmann, Karin Wiesner, Sandro Kevin Fischer, Martina Wiegert, Wilma Dj Verhagen-Kamerbeek, Yannik Rottenberger, Anne Schwarz, Nils Peters, Henrik Gensicke, Friedrich Medlin, Jens Carsten Möller, Bartosz Bujan, Leo H Bonati, Marcel Arnold, Sabine Schaedelin, René M Müri, Lars G Hemkens, Patrik Michel, Philippe A Lyrer, Jeremia P Held, Gary A Ford, Andreas R Luft, Christopher Traenka, Stefan T Engelter (2024) <i>European stroke journal</i> <i></i> <i></i> 9: 4 1093-1102<br/>

//publicationslist.org/tobias.nef/refid614 2024-05-03T05:58:53Z

Flow can be described as a subjective state that people report when they fully engage in an activity and experience pleasure, satisfaction, and enjoyment. Flow experiences are measured to determine the extent to which patients engage in therapy activities. Several flow questionnaires are used in neurorehabilitation. However, none have been validated for patients with (sub)acute stroke.<br/><br/>Beatrice Ottiger, Janne Marieke Veerbeek, Dario Cazzoli, Thomas Nyffeler, Tim Vanbellingen (2024) <i>The American journal of occupational therapy : official publication of the American Occupational Therapy Association</i> <i></i> <i></i> 78: 2 <br/>

//publicationslist.org/tobias.nef/refid610 2024-04-15T12:55:38Z

Pareidolia are perceptions of recognizable images or meaningful patterns where none exist. In recent years, this phenomenon has been increasingly studied in healthy subjects and patients with neurological or psychiatric diseases. The current study examined pareidolia production in a group of 53 stroke patients and 82 neurologically healthy controls who performed a natural images task. We found a s...<br/><br/>M Camenzind, N Göbel, A K Eberhard-Moscicka, S E J Knobel, H Hegi, M Single, B C Kaufmann, R Schumacher, T Nyffeler, T Nef, R M Müri (2024) <i>Heliyon</i> <i></i> <i></i> 10: 5 <br/>

//publicationslist.org/tobias.nef/refid612 2024-05-03T05:57:51Z

Exercise therapy may increase brain-derived neurotrophic factor (BDNF) levels and improve clinical outcomes in people living with Parkinson's disease (PD). This systematic review was performed to investigate the effect of exercise therapy on BDNF levels and clinical outcomes in human PD and to discuss mechanisms proposed by authors.<br/><br/>Daan G M Kaagman, Erwin E H van Wegen, Natalie Cignetti, Emily Rothermel, Tim Vanbellingen, Mark A Hirsch (2024) <i>Brain sciences</i> <i></i> <i></i> 14: 3 <br/>

//publicationslist.org/tobias.nef/refid622 2024-07-09T10:41:43Z

Analyzing irregularities in walking patterns helps detect human locomotion abnormalities that can signal health changes. Traditional observation-based assessments have limitations due to subjective biases and capture only a single time point. Ambient and wearable sensor technologies allow continuous and objective locomotion monitoring but face challenges due to the need for specialized expertise a...<br/><br/>Michael Single, Lena C Bruhin, Aileen C Naef, Paul Krack, Tobias Nef, Stephan M Gerber (2024) <i>Scientific reports</i> <i></i> <i></i> 14: 1 <br/>

//publicationslist.org/tobias.nef/refid621 2024-06-06T06:50:55Z

The results of telemedicine intervention studies in patients with heart failure (HF) to reduce rehospitalization rate and mortality by early detection of HF decompensation are encouraging. However, the benefits are lower than expected. A possible reason for this could be the fact that vital signs, including blood pressure, heart rate, heart rhythm, and weight changes, may not be ideal indicators o...<br/><br/>Benjamin Vögeli, Nisha Arenja, Narayan Schütz, Tobias Nef, Philipp Buluschek, Hugo Saner (2024) <i>JMIR research protocols</i> <i></i> <i></i> 13: <br/>

//publicationslist.org/tobias.nef/refid624 2025-05-08T14:24:28Z

Chronic pain presents a significant treatment challenge, often leading to frustration for both patients and therapists due to the limitations of traditional methods. Research has shown that synchronous visuo-tactile stimulation, as used in the rubber hand experiment, can induce a sense of ownership over a fake body part and reduces pain perception when ownership of the fake body part is reported. ...<br/><br/>Samuel E J Knobel, Raphael Oberson, Jonas Räber, Narayan Schütz, Niklaus Egloff, Angela Botros, Stephan M Gerber, Tobias Nef, Lukas Heydrich (2024) <i>JMIR serious games</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid605 2024-02-23T07:57:44Z

Spatial neglect is characterized by the failure to attend stimuli presented in the contralesional space. Typically, the visual modality is more severely impaired than the auditory one. This dissociation offers the possibility of cross-modal interactions, whereby auditory stimuli may have beneficial effects on the visual modality. A new auditory motion stimulation method with music dynamically movi...<br/><br/>Nora Geiser, Brigitte Charlotte Kaufmann, Samuel Elia Johannes Knobel, Dario Cazzoli, Tobias Nef, Thomas Nyffeler (2024) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 171: 194-203<br/>

//publicationslist.org/tobias.nef/refid611 2024-04-15T12:56:42Z

Gait abnormalities in older adults are linked to increased risks of falls, institutionalization, and mortality, necessitating accurate and frequent gait assessments beyond traditional clinical settings. Current methods, such as pressure-sensitive walkways, often lack the continuous natural environment monitoring needed to understand an individual's gait fully during their daily activities. To addr...<br/><br/>Michael Single, Lena C Bruhin, Aaron Colombo, Kevin Möri, Stephan M Gerber, Jacob Lahr, Paul Krack, Stefan Klöppel, René M Müri, Urs P Mosimann, Tobias Nef (2024) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 24: 4 <br/>

//publicationslist.org/tobias.nef/refid645 2026-04-30T05:55:51Z

There is currently a lack of easy-to-use and effective robotic devices for upper-limb rehabilitation after stroke. Importantly, most current systems lack the provision of somatosensory information that is congruent with the virtual training task. This paper introduces a novel haptic robotic system designed for upper-limb rehabilitation, focusing on enhancing sensorimotor rehabilitation through com...<br/><br/>Raphael Rätz, François Conti, Irène Thaler, René M Müri, Laura Marchal-Crespo (2024) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 21: 1 <br/>

//publicationslist.org/tobias.nef/refid601 2023-04-28T09:05:29Z

Parallel test versions require a comparable degree of difficulty and must capture the same characteristics using different items. This can become challenging when dealing with multivariate items, which are for example very common in language or image data. Here, we propose a heuristic to identify and select similar multivariate items for the generation of equivalent parallel test versions. This he...<br/><br/>Nicole Göbel, Dario Cazzoli, Clemens Gutbrod, René M Müri, Aleksandra K Eberhard-Moscicka (2023) <i>PloS one</i> <i></i> <i></i> 18: 4 <br/>

//publicationslist.org/tobias.nef/refid603 2023-08-11T07:43:06Z

Odors evoking vivid and intensely felt autobiographical memories are known as the "Proust phenomenon," delineating the particularity of olfaction in being more effective with eliciting emotional memories than other sensory modalities. The phenomenon has been described extensively in healthy participants as well as in patients during pre-epilepsy surgery evaluation after focal stimulation of the am...<br/><br/>Sophie De Beukelaer, A A Sokolov, R M Müri (2023) <i>Frontiers in neurology</i> <i></i> <i></i> 14: <br/>

//publicationslist.org/tobias.nef/refid602 2023-08-11T07:41:28Z

Exposure to elevated sound pressure levels within the intensive care unit is known to negatively affect patient and staff health. In the past, interventions to address this problem have been unsuccessful as there is no conclusive evidence on the severity of each sound source and their role on the overall sound pressure levels. Therefore, the goal of the study was to perform a continuous 1 week rec...<br/><br/>Aileen C Naef, Samuel E J Knobel, Nicole Ruettgers, Marilyne Rossier, Marie-Madlen Jeitziner, Bjoern Zante, René M Müri, Joerg C Schefold, Tobias Nef, Stephan M Gerber (2023) <i>Frontiers in medicine</i> <i></i> <i></i> 10: <br/>

//publicationslist.org/tobias.nef/refid599 2023-06-06T09:30:52Z

In this study, the feasibility of Action Observation Training (AOT) in combination with sensor-based measurements in infants at high risk of Unilateral Spastic Cerebral Palsy (UCP) were evaluated. Over a four-week period, eight infants at high risk of UCP performed AOT at home while wearing sensors with assistance of caregivers. Sensor data were compared to clinical assessments of upper limb funct...<br/><br/>Miriam von Gunten, Angela Botros, Bernadette Tobler-Ammann, Tobias Nef, Sebastian Grunt (2023) <i>Developmental neurorehabilitation</i> <i></i> <i></i> 26: 4 234-243<br/>

//publicationslist.org/tobias.nef/refid586 2023-04-28T09:04:04Z

In everyday life, information from different cognitive domains-such as visuospatial attention, alertness and inhibition-needs to be integrated between different brain regions. Early models suggested that completely segregated brain networks control these three cognitive domains. However, more recent accounts, mainly based on neuroimaging data in healthy participants, indicate that different tasks ...<br/><br/>Brigitte C Kaufmann, Dario Cazzoli, Manuela Pastore-Wapp, Tim Vanbellingen, Tobias Pflugshaupt, Daniel Bauer, René M Müri, Tobias Nef, Paolo Bartolomeo, Thomas Nyffeler (2023) <i>Brain : a journal of neurology</i> <i></i> <i></i> 146: 4 1467-1482<br/>

//publicationslist.org/tobias.nef/refid590 2023-06-06T09:31:49Z

The mechanisms of action of high-frequency stimulation (HFS) are unknown. We investigated the possible mechanism of subthreshold superexcitability of HFS on the excitability of the peripheral nerve.<br/><br/>Vedran Deletis, Jay Shils, Juan Anso, Eduardo Villar Ortega, Laura Marchal-Crespo, Karin A Buetler, Andreas Raabe, Kathleen Seidel (2023) <i>Neuromodulation : journal of the International Neuromodulation Society</i> <i></i> <i></i> 26: 3 614-619<br/>

//publicationslist.org/tobias.nef/refid604 2024-02-23T08:06:53Z

Reduplicative paramnesia refers to the delusional belief that there are identical places in different locations. In this case-control study we investigated the clinical, phenomenological, neuropsychological and neuroanatomical data of eleven patients with reduplicative paramnesia and compared them against a control group of eleven patients with severe spatial disorientation without signs of redupl...<br/><br/>A A Diamantaras, E Blondiaux, R Schumacher, R M Müri, O Blanke, L Heydrich (2023) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 167: 12-24<br/>

//publicationslist.org/tobias.nef/refid593 2023-03-16T09:18:35Z

Virtual reality (VR) is a promising tool to promote motor (re)learning in healthy users and brain-injured patients. However, in current VR-based motor training, movements of the users performed in a three-dimensional space are usually visualized on computer screens, televisions, or projection systems, which lack depth cues (2D screen), and thus, display information using only monocular depth cues....<br/><br/>N Wenk, J Penalver-Andres, K A Buetler, T Nef, R M Müri, L Marchal-Crespo (2023) <i>Virtual reality</i> <i></i> <i></i> 27: 1 307-331<br/>

//publicationslist.org/tobias.nef/refid594 2023-07-03T08:56:55Z

Isolated rapid eye movement sleep behavior disorder (iRBD) is a parasomnia characterized by dream enactment. It represents a prodromal state of α-synucleinopathies, like Parkinson's disease. In recent years, biomarkers of increased risk of phenoconversion from iRBD to overt α-synucleinopathies have been identified. Currently, diagnosis and monitoring rely on self-reported reports and polysomnogr...<br/><br/>Oriella Gnarra, Marie-Angela Wulf, Carolin Schäfer, Tobias Nef, Claudio L A Bassetti (2023) <i>Sleep</i> <i></i> <i></i> 46: 6 <br/>

//publicationslist.org/tobias.nef/refid595 2023-03-16T09:19:40Z

Digital sensing devices have become an increasingly important component of modern biomedical research, as they help provide objective insights into individuals' everyday behavior in terms of changes in motor and nonmotor symptoms. However, there are significant barriers to the adoption of sensor-enhanced biomedical solutions in terms of both technical expertise and associated costs. The currently ...<br/><br/>Michael Single, Lena C Bruhin, Narayan Schütz, Aileen C Naef, Heinz Hegi, Pascal Reuse, Kaspar A Schindler, Paul Krack, Roland Wiest, Andrew Chan, Tobias Nef, Stephan M Gerber (2023) <i>JMIR formative research</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid596 2023-03-16T09:21:54Z

We often interact with our environment through manual handling of objects and exploration of their properties. Object properties (OP), such as texture, stiffness, size, shape, temperature, weight, and orientation provide necessary information to successfully perform interactions. The human haptic perception system plays a key role in this. As virtual reality (VR) has been a growing field of intere...<br/><br/>Myla van Wegen, Just L Herder, Rolf Adelsberger, Manuela Pastore-Wapp, Erwin E H van Wegen, Stephan Bohlhalter, Tobias Nef, Paul Krack, Tim Vanbellingen (2023) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 23: 3 <br/>

//publicationslist.org/tobias.nef/refid600 2023-04-03T07:33:43Z

In the past decade, there has been substantial progress in the development of robotic controllers that specify how lower-limb exoskeletons should interact with brain-injured patients. However, it is still an open question which exoskeleton control strategies can more effectively stimulate motor function recovery. In this review, we aim to complement previous literature surveys on the topic of exos...<br/><br/>Jesús de Miguel-Fernández, Joan Lobo-Prat, Erik Prinsen, Josep M Font-Llagunes, Laura Marchal-Crespo (2023) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 20: 1 <br/>

//publicationslist.org/tobias.nef/refid616 2024-05-03T05:59:47Z

Background Laboratory-based assessments have shown that stroke recovery is heterogeneous between patients and affected domains such as motor and language function. However, laboratory-based assessments are not ecologically valid and do not necessarily reflect patients' daily life performance. Therefore, we aimed to give an innovative view on stroke recovery by profiling daily life performance reco...<br/><br/>Janne M Veerbeek, Clemens Hutter, Beatrice Ottiger, Soel Micheletti, Simone Riedi, Enrico Bianchi, Noortje Maaijwee, Tim Vanbellingen, Thomas Nyffeler (2023) <i>Journal of the American Heart Association</i> <i></i> <i></i> 12: 16 <br/>

//publicationslist.org/tobias.nef/refid615 2024-05-03T05:58:53Z

Hemispatial neglect, the inability to attend to the contralesional side of space, is the most common disturbance of visuospatial attention. Both hemispatial neglect and visuospatial attention are typically associated with extended cortical networks. Nevertheless, recent accounts challenge this so-called corticocentric view and postulate the participation of structures well beyond the telencephalic...<br/><br/>Dario Cazzoli, Brigitte C Kaufmann, Henrik Rühe, Nora Geiser, Tim Vanbellingen, Thomas Nyffeler (2023) <i>Journal of neurophysiology</i> <i></i> <i></i> 129: 6 1534-1539<br/>

//publicationslist.org/tobias.nef/refid617 2024-05-03T05:59:47Z

Impaired manual dexterity is frequent and disabling in patients with multiple sclerosis (MS), affecting activities of daily living and quality of life.<br/><br/>Christian P Kamm, Remo Blättler, Roger Kueng, Tim Vanbellingen (2023) <i>Multiple sclerosis and related disorders</i> <i></i> <i></i> 71: <br/>

//publicationslist.org/tobias.nef/refid618 2024-05-03T06:00:34Z

About 77% of adults with stroke have upper limb impairments. Many scales are available to measure the impairment and activity level of the affected limb. However, an observational scale to assess dependency on others in upper limb performance during daily life activities instead of laboratory settings is lacking. Therefore, we developed a new 5-item Upper Limb Lucerne ICF-based Multidisciplinary O...<br/><br/>Ann Van de Winckel, Beatrice Ottiger, Janne Marieke Veerbeek, Thomas Nyffeler, Tim Vanbellingen (2023) <i>Frontiers in neurology</i> <i></i> <i></i> 14: <br/>

//publicationslist.org/tobias.nef/refid619 2024-05-03T06:11:02Z

Tim Vanbellingen (2023) <i>Revue medicale suisse</i> <i></i> <i></i> 19: 811 136-137<br/>

//publicationslist.org/tobias.nef/refid620 2024-05-03T06:11:25Z

Persons with Parkinson's disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL), inter alia due to dysfunctional supplementary motor area (SMA). Combined intermittent theta-burst stimulation (iTBS) over the SMA followed by video game-based training (VBT) may therefore improve dexterity related ADL. The VBT may induce high flow levels relat...<br/><br/>Manuela Pastore-Wapp, Brigitte C Kaufmann, Thomas Nyffeler, Simona Wapp, Stephan Bohlhalter, Tim Vanbellingen (2023) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 20: 1 <br/>

//publicationslist.org/tobias.nef/refid613 2024-05-03T05:57:51Z

Physical exercise is receiving increasing interest as an augmentative non-pharmacological intervention in Parkinson's disease (PD). This pilot study primarily aimed to quantify individual response patterns of motor symptoms to alternating exercise modalities, along with non-motor functioning and blood biomarkers of neuroplasticity and neurodegeneration.<br/><br/>Elvira S Amaral Gomes, Odile A Van den Heuvel, Marc B Rietberg, Vincent De Groot, Mark A Hirsch, Wilma D J Van de Berg, Richard T Jaspers, Chris Vriend, Tim Vanbellingen, Erwin E H Van Wegen (2023) <i>Brain sciences</i> <i></i> <i></i> 13: 6 <br/>

//publicationslist.org/tobias.nef/refid606 2024-02-23T07:57:44Z

Sensory overload and sensory deprivation have both been associated with negative health outcomes in critically ill patients. While there is a lack of any clear treatment or prevention strategies, immersive virtual reality is a promising tool for addressing such problems, but which has not been repetitively tested in random samples. Therefore, this study aimed to determine how critically ill patien...<br/><br/>Aileen C Naef, Stephan M Gerber, Michael Single, René M Müri, Matthias Haenggi, Stephan M Jakob, Marie-Madlen Jeitziner, Tobias Nef (2023) <i>Frontiers in medicine</i> <i></i> <i></i> 10: <br/>

//publicationslist.org/tobias.nef/refid608 2024-02-23T07:58:22Z

The use of virtual reality (VR) stimulation in clinical settings has increased in recent years. In particular, there has been increasing interest in the use of VR stimulation for a variety of purposes, including medical training, pain therapy, and relaxation. Unfortunately, there is still a limited amount of real-world 360-degree content that is both available and suitable for these applications. ...<br/><br/>Aileen C Naef, Marie-Madlen Jeitziner, Stephan M Jakob, René M Müri, Tobias Nef (2023) <i>JMIR medical education</i> <i></i> <i></i> 9: <br/>

//publicationslist.org/tobias.nef/refid609 2024-02-23T07:58:59Z

Promoting cognitive health is key to maintaining cognitive and everyday functions and preventing the risk of cognitive impairment or dementia. Existing scientific evidence shows the benefits of various training modalities on cognition. One way to promote cognitive health is through engagement in cognitive activities (eg, board and video games).<br/><br/>Prabitha Urwyler, Rajnish Kumar Gupta, Michael Falkner, Joel Niklaus, René Martin Müri, Tobias Nef (2023) <i>JMIR aging</i> <i></i> <i></i> 6: <br/>

//publicationslist.org/tobias.nef/refid607 2024-02-23T07:58:22Z

Sleep is crucial in rehabilitation processes, promoting neural plasticity and immune functions. Nocturnal body postures can indicate sleep quality and frequent repositioning is required to prevent bedsores for bedridden patients after a stroke or spinal cord injury. Polysomnography (PSG) is considered the gold standard for sleep assessment. Unobtrusive methods for classifying sleep body postures h...<br/><br/>Oriella Gnarra, Alexander Breuss, Lorenzo Rossi, Manuel Fujs, Samuel E J Knobel, Jan D Warncke, Stephan M Gerber, Claudio L A Bassetti, Robert Riener, Tobias Nef, Markus H Schmidt (2023) <i>IEEE ... International Conference on Rehabilitation Robotics : [proceedings]</i> <i></i> <i></i> 2023: 1-6<br/>

//publicationslist.org/tobias.nef/refid573 2022-09-27T12:46:20Z

This pilot cross-sectional study aimed to evaluate the usability of two new interactive game sensor-based hand devices (GripAble and Smart Sensor Egg) in both healthy adults as well as in persons with Parkinson's Disease (PD). Eight healthy adults and eight persons with PD participated in this study. Besides a standardised usability measure, the state of flow after one training session and the eff...<br/><br/>Lea Saric, Samuel E J Knobel, Manuela Pastore-Wapp, Tobias Nef, Fred W Mast, Tim Vanbellingen (2022) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 22: 16 <br/>

//publicationslist.org/tobias.nef/refid575 2022-10-31T14:16:53Z

To determine what type (e.g., television, photographs, music, etc), content (e.g., nature scenes, family members, etc), and duration of visual and auditory stimuli should be provided to intensive care unit patients during their hospitalisation.<br/><br/>Aileen C Naef, Katja Erne, Matthias Thomas Exl, Tobias Nef, Marie-Madlen Jeitziner (2022) <i>Intensive & critical care nursing</i> <i></i> <i></i> 73: <br/>

//publicationslist.org/tobias.nef/refid577 2022-09-27T12:48:44Z

Virtual reality (VR) devices are increasingly being used in medicine and other areas for a broad spectrum of applications. One of the possible applications of VR involves the creation of an environment manipulated in a way that helps patients with disturbances in the spatial allocation of visual attention (so-called hemispatial neglect). One approach to ameliorate neglect is to apply cross-modal c...<br/><br/>Samuel Elia Johannes Knobel, Brigitte Charlotte Kaufmann, Nora Geiser, Stephan Moreno Gerber, René M Müri, Tobias Nef, Thomas Nyffeler, Dario Cazzoli (2022) <i>JMIR serious games</i> <i></i> <i></i> 10: 2 <br/>

//publicationslist.org/tobias.nef/refid576 2022-09-27T12:48:16Z

Despite many studies in the field examining excessive noise in the intensive care unit, this issue remains an ongoing problem. A limiting factor in the progress of the field is the inability to draw conclusions across studies due to the different and poorly reported approaches used. Therefore, the first goal is to present a method for the general measurement of sound pressure levels and sound sour...<br/><br/>Aileen C Naef, Samuel E J Knobel, Nicole Ruettgers, Marie-Madlen Jeitziner, Martin Grosse Holtforth, Bjoern Zante, Joerg C Schefold, Tobias Nef, Stephan M Gerber (2022) <i>Frontiers in medicine</i> <i></i> <i></i> 9: <br/>

//publicationslist.org/tobias.nef/refid574 2022-09-27T12:46:57Z

Using connected sensing devices to remotely monitor health is a promising way to help transition healthcare from a rather reactive to a more precision medicine oriented proactive approach, which could be particularly relevant in the face of rapid population ageing and the challenges it poses to healthcare systems. Sensor derived digital measures of health, such as digital biomarkers or digital cli...<br/><br/>Narayan Schütz, Samuel E J Knobel, Angela Botros, Michael Single, Bruno Pais, Valérie Santschi, Daniel Gatica-Perez, Philipp Buluschek, Prabitha Urwyler, Stephan M Gerber, René M Müri, Urs P Mosimann, Hugo Saner, Tobias Nef (2022) <i>NPJ digital medicine</i> <i></i> <i></i> 5: 1 <br/>

//publicationslist.org/tobias.nef/refid559 2022-03-21T13:59:04Z

Noise exposure leads to a reduction in cognitive abilities in diverse settings, however, only limited data exist examining the effects of environmental ICU noise on the cognitive performance of ICU professionals. A frequently occurring and demanding retention task in ICUs are ward rounds, which are considered key for the provision of medical care. Here, we investigate the influence of noise on inf...<br/><br/>Katja Erne, Samuel E J Knobel, Aileen C Naef, Stephan M Gerber, Tim Fischer, Fred W Mast, Joerg C Schefold, Bjoern Zante, Tobias Nef, Marie-Madlen Jeitziner (2022) <i>Intensive care medicine experimental</i> <i></i> <i></i> 10: 1 <br/>

//publicationslist.org/tobias.nef/refid557 2022-03-21T13:57:59Z

After cerebellar stroke, cognition can be impaired, as described within the framework of the so-called Cerebellar Cognitive Affective Syndrome (CCAS). However, it remains unclear whether visual neglect can also be part of CCAS. We describe the case of a patient with a subacute cerebellar stroke after thrombosis of the left posterior inferior cerebellar artery (PICA), who showed a left-sided visual...<br/><br/>Nora Geiser, Brigitte Charlotte Kaufmann, Henrik Rühe, Noortje Maaijwee, Tobias Nef, Dario Cazzoli, Thomas Nyffeler (2022) <i>Brain sciences</i> <i></i> <i></i> 12: 2 <br/>

//publicationslist.org/tobias.nef/refid556 2022-03-21T13:56:10Z

For patients suffering from neurodegenerative disorders, the behavior and activities of daily living are an indicator of a change in health status, and home-monitoring over a prolonged period of time by unobtrusive sensors is a promising technology to foster independent living and maintain quality of life. The aim of this pilot case study was the development of a multi-sensor system in an apartmen...<br/><br/>Stephan M Gerber, Michael Single, Samuel E J Knobel, Narayan Schütz, Lena C Bruhin, Angela Botros, Aileen C Naef, Kaspar A Schindler, Tobias Nef (2022) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 22: 4 <br/>

//publicationslist.org/tobias.nef/refid558 2022-03-21T13:58:33Z

Spatial neglect after right-hemispheric stroke, characterized by the failure to attend or respond to the contralesional space, is a strong negative outcome predictor. Neglect is a supramodal syndrome affecting not only the visual but also the auditory modality. Preliminary studies used this audio-visual cross-modal effect to show short-lasting effects on attention towards the neglected space. The ...<br/><br/>B C Kaufmann, D Cazzoli, P Bartolomeo, J Frey, T Pflugshaupt, S E J Knobel, T Nef, R M Müri, T Nyffeler (2022) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 148: 152-167<br/>

//publicationslist.org/tobias.nef/refid579 2022-09-27T12:49:39Z

The use of robotic technology for neurorehabilitative applications has become increasingly important for adults and children with different motor impairments.<br/><br/>Farouk Chrif, Hubertus J A van Hedel, Mauro Vivian, Tobias Nef, Kenneth J Hunt (2022) <i>Technology and health care : official journal of the European Society for Engineering and Medicine</i> <i></i> <i></i> 30: 5 1183-1197<br/>

//publicationslist.org/tobias.nef/refid568 2022-10-31T14:22:45Z

Current robot-aided training allows for high-intensity training but might hamper the transfer of learned skills to real daily tasks. Many of these tasks, e.g., carrying a cup of coffee, require manipulating objects with complex dynamics. Thus, the absence of somatosensory information regarding the interaction with virtual objects during robot-aided training might be limiting the potential benefits...<br/><br/>Özhan Özen, Karin A Buetler, Laura Marchal-Crespo (2022) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 19: 1 <br/>

//publicationslist.org/tobias.nef/refid563 2022-10-31T14:17:57Z

Hallucinations occur across neurodegenerative disorders, with increasing severity, poorer cognition and impaired hallucination-specific insight associated with worse outcomes and faster disease progression. It remains unclear how changes in cognition, temporal aspects of hallucinations, hallucination-specific insight and distress relate to each other. Extant samples of patients experiencing visual...<br/><br/>Marcella Montagnese, Miriam Vignando, Daniel Collerton, Dominic Ffytche, Urs Peter Mosimann, John-Paul Taylor, Katrina daSilva Morgan, Prabitha Urwyler (2022) <i>Cognitive neuropsychiatry</i> <i></i> <i></i> 27: 2-3 105-121<br/>

//publicationslist.org/tobias.nef/refid569 2022-10-31T14:23:44Z

Combining immersive virtual reality (VR) using head-mounted displays (HMDs) with assisting robotic devices might be a promising procedure to enhance neurorehabilitation. However, it is still an open question how immersive virtual environments (VE) should be designed when interacting with rehabilitation robots. In conventional training, the robot is usually not visually represented in the VE, resul...<br/><br/>Nicolas Wenk, Mirjam V Jordi, Karin A Buetler, Laura Marchal-Crespo (2022) <i>IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society</i> <i></i> <i></i> 30: 390-399<br/>

//publicationslist.org/tobias.nef/refid578 2022-09-27T12:49:05Z

With growing use of machine learning algorithms and big data in health applications, digital measures, such as digital biomarkers, have become highly relevant in digital health. In this paper, we focus on one important use case, the long-term continuous monitoring of cognitive ability in older adults. Cognitive ability is a factor both for long-term monitoring of people living alone as well as a r...<br/><br/>Angela A Botros, Narayan Schuetz, Christina Röcke, Robert Weibel, Mike Martin, René M Müri, Tobias Nef (2022) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 22: 7 <br/>

//publicationslist.org/tobias.nef/refid597 2023-03-16T09:24:13Z

The noise levels in intensive care units have been repeatedly reported to exceed the recommended guidelines and yield negative health outcomes among healthcare professionals. However, it is unclear which sound sources within this environment are perceived as disturbing. Therefore, this study aimed to evaluate how healthcare professionals in Germany, Switzerland, and Austria perceive the sound leve...<br/><br/>Nicole Ruettgers, Aileen C Naef, Marilyne Rossier, Samuel E J Knobel, Marie-Madlen Jeitziner, Martin Grosse Holtforth, Bjoern Zante, Joerg C Schefold, Tobias Nef, Stephan M Gerber (2022) <i>PloS one</i> <i></i> <i></i> 17: 12 <br/>

//publicationslist.org/tobias.nef/refid591 2022-12-29T09:25:00Z

Developing motor and cognitive skills is needed to achieve expert (motor) performance or functional recovery from a neurological condition, e.g., after stroke. While extensive practice plays an essential role in the acquisition of good motor performance, it is still unknown whether certain person-specific traits may predetermine the rate of motor learning. In particular, learners' functional brain...<br/><br/>Joaquin A Penalver-Andres, Karin A Buetler, Thomas Koenig, René M Müri, Laura Marchal-Crespo (2022) <i>Brain topography</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid588 2022-10-31T14:20:13Z

Stroke survivors are commonly affected by somatosensory impairment, hampering their ability to interpret somatosensory information. Somatosensory information has been shown to critically support movement execution in healthy individuals and stroke survivors. Despite the detrimental effect of somatosensory impairments on performing activities of daily living, somatosensory training-in stark contras...<br/><br/>Eduardo Villar Ortega, Efe Anil Aksöz, Karin A Buetler, Laura Marchal-Crespo (2022) <i>Frontiers in rehabilitation sciences</i> <i></i> <i></i> 3: <br/>

//publicationslist.org/tobias.nef/refid589 2022-10-31T14:21:08Z

Sensorimotor impairments of the hand after stroke can drastically reduce the ability to perform activities of daily living. Recently, there has been an increased interest in minimally supervised and unsupervised rehabilitation to increase therapy dosage and to complement conventional therapy. Several devices have been developed that are simple to use and portable. Yet, they do not incorporate dive...<br/><br/>Nathan Van Damme, Raphael Ratz, Laura Marchal-Crespo (2022) <i>IEEE ... International Conference on Rehabilitation Robotics : [proceedings]</i> <i></i> <i></i> 2022: 1-6<br/>

//publicationslist.org/tobias.nef/refid598 2023-03-16T09:25:27Z

Jonas Marschall, Hilary M Babcock, Urs P Mosimann (2022) <i>Antimicrobial stewardship & healthcare epidemiology : ASHE</i> <i></i> <i></i> 2: 1 <br/>

//publicationslist.org/tobias.nef/refid592 2022-12-29T09:25:36Z

The relearning of movements after brain injury can be optimized by providing intensive, meaningful, and motivating training using virtual reality (VR). However, most current solutions use two-dimensional (2D) screens, where patients interact via symbolic representations of their limbs (e.g., a cursor). These 2D screens lack depth cues, potentially deteriorating movement quality and increasing cogn...<br/><br/>Nicolas Wenk, Karin A Buetler, Joaquin Penalver-Andres, René M Müri, Laura Marchal-Crespo (2022) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 19: 1 <br/>

//publicationslist.org/tobias.nef/refid585 2022-10-31T14:13:59Z

Stress is a part of everyday life which can be counteracted by evoking the relaxation response via nature scenes presented using immersive virtual reality (VR). The aim of this study was to determine which sensory aspect of immersive VR intervention is responsible for the greatest relaxation response. We compared four conditions: auditory and visual combined (audiovisual), auditory only, visual on...<br/><br/>Aileen C Naef, Marie-Madlen Jeitziner, Samuel E J Knobel, Matthias Thomas Exl, René M Müri, Stephan M Jakob, Tobias Nef, Stephan M Gerber (2022) <i>Scientific reports</i> <i></i> <i></i> 12: 1 <br/>

//publicationslist.org/tobias.nef/refid581 2022-09-27T12:52:27Z

Brain fog is a common and highly disturbing symptom for patients with neuropathic postural tachycardia syndrome (POTS). Cognitive deficits have been measured exclusively in the upright body position and mainly comprised impairments of higher cognitive functions. The cause of brain fog is still unclear today. This study aimed to investigate whether increased autonomic activation might be an underly...<br/><br/>Belén Rodriguez, Annie Hochstrasser, Philippe J Eugster, Eric Grouzmann, René M Müri, Werner J Z'Graggen (2022) <i>Frontiers in neuroscience</i> <i></i> <i></i> 16: <br/>

//publicationslist.org/tobias.nef/refid582 2022-09-27T12:53:50Z

Mental imagery is a powerful capability that engages similar neurophysiological processes that underlie real sensory and motor experiences. Previous studies show that motor cortical excitability can increase during mental imagery of actions. In this study, we focused on possible inhibitory effects of mental imagery on motor functions. We assessed whether imagined arm paralysis modulates motor cort...<br/><br/>Matthias Hartmann, Caroline J Falconer, Alain Kaelin-Lang, René M Müri, Fred W Mast (2022) <i>Psychophysiology</i> <i></i> <i></i> 59: 10 <br/>

//publicationslist.org/tobias.nef/refid583 2022-10-31T14:11:50Z

Mobile health applications (mHealth apps) may lead to health benefits. In recent years, the use of apps in multiple sclerosis (MS) has increased. Apps to train and improve dexterity in MS are scarce. This study investigated the effectiveness of a tablet app-based home-based training to improve dexterity in individuals with MS.<br/><br/>Judith J W van Beek, Dirk Lehnick, Manuela Pastore-Wapp, Simona Wapp, Christian P Kamm, Tobias Nef, Tim Vanbellingen (2022) <i>Disability and rehabilitation. Assistive technology</i> <i></i> <i></i> : 1-11<br/>

//publicationslist.org/tobias.nef/refid584 2022-12-29T09:23:39Z

B C Kaufmann, D Cazzoli, P Bartolomeo, N Geiser, T Nef, T Nyffeler (2022) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 157: 336-337<br/>

//publicationslist.org/tobias.nef/refid580 2022-09-27T12:51:59Z

To address the clinical need for high-intensity, repetitive sensorimotor hand training after stroke, we developed in a first step a novel haptic device for practicing finger movements. Because the thumb plays a fundamental role in the loss of autonomy and prehensile functions after stroke, we present here the development of a thumb module that complements our previous design. The novelties of our ...<br/><br/>Raphael Ratz, Rene M Muri, Laura Marchal-Crespo (2022) <i>Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference</i> <i></i> <i></i> 2022: 2644-2647<br/>

//publicationslist.org/tobias.nef/refid547 2021-09-03T09:32:44Z

Population aging is posing multiple social and economic challenges to society. One such challenge is the social and economic burden related to increased health care expenditure caused by early institutionalizations. The use of modern pervasive computing technology makes it possible to continuously monitor the health status of community-dwelling older adults at home. Early detection of health issue...<br/><br/>Narayan Schütz, Hugo Saner, Angela Botros, Bruno Pais, Valérie Santschi, Philipp Buluschek, Daniel Gatica-Perez, Prabitha Urwyler, René M Müri, Tobias Nef (2021) <i>JMIR mHealth and uHealth</i> <i></i> <i></i> 9: 6 <br/>

//publicationslist.org/tobias.nef/refid549 2021-09-03T09:31:45Z

In immersive virtual reality, the own body is often visually represented by an avatar. This may induce a feeling of body ownership over the virtual limbs. Importantly, body ownership and the motor system share neural correlates. Yet, evidence on the functionality of this neuroanatomical coupling is still inconclusive. Findings from previous studies may be confounded by the congruent vs. incongruen...<br/><br/>Ingrid A Odermatt, Karin A Buetler, Nicolas Wenk, Özhan Özen, Joaquin Penalver-Andres, Tobias Nef, Fred W Mast, Laura Marchal-Crespo (2021) <i>Frontiers in neuroscience</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid548 2021-06-28T10:01:48Z

In a parallel development to traditional rigid rehabilitation robotic systems, cable-driven systems are becoming popular. The robowalk expander product uses passive elastic bands in the training of the lower limbs. However, a well-controlled assistance or resistance is desirable for effective walking relearning and muscle training. To achieve well-controlled force during locomotion training with t...<br/><br/>Juan Fang, Michael Haldimann, Laura Marchal-Crespo, Kenneth J Hunt (2021) <i>Frontiers in neurorobotics</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid546 2021-06-28T09:56:35Z

[This corrects the article DOI: 10.3389/fneur.2020.00875.].<br/><br/>Johannes Pohl, Jeremia Philipp Oskar Held, Geert Verheyden, Margit Alt Murphy, Stefan Engelter, Agnes Flöel, Thierry Keller, Gert Kwakkel, Tobias Nef, Nick Ward, Andreas Rüdiger Luft, Janne Marieke Veerbeek (2021) <i>Frontiers in neurology</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid550 2021-09-03T09:32:26Z

Serious games are gaining increasing importance in neurorehabilitation since they increase motivation and adherence to therapy, thereby potentially improving its outcome. The benefits of serious games, such as the possibility to implement adaptive feedback and the calculation of comparable performance measures, can be even further improved by using immersive virtual reality (iVR), allowing a more ...<br/><br/>Samuel Elia Johannes Knobel, Brigitte Charlotte Kaufmann, Stephan Moreno Gerber, Prabitha Urwyler, Dario Cazzoli, René M Müri, Tobias Nef, Thomas Nyffeler (2021) <i>JMIR serious games</i> <i></i> <i></i> 9: 3 <br/>

//publicationslist.org/tobias.nef/refid539 2021-03-29T10:48:03Z

Recent studies suggest that computerized puzzle games are enjoyable, easy to play, and engage attentional, visuospatial, and executive functions. They may help mediate impairments seen in cognitive decline in addition to being an assessment tool. Eye tracking provides a quantitative and qualitative analysis of gaze, which is highly useful in understanding visual search behavior.<br/><br/>Christine Krebs, Michael Falkner, Joel Niklaus, Luca Persello, Stefan Klöppel, Tobias Nef, Prabitha Urwyler (2021) <i>JMIR serious games</i> <i></i> <i></i> 9: 1 <br/>

//publicationslist.org/tobias.nef/refid535 2021-01-29T08:13:32Z

Hallucinations can occur in different sensory modalities, both simultaneously and serially in time. They have typically been studied in clinical populations as phenomena occurring in a single sensory modality. Hallucinatory experiences occurring in multiple sensory systems-multimodal hallucinations (MMHs)-are more prevalent than previously thought and may have greater adverse impact than unimodal ...<br/><br/>Marcella Montagnese, Pantelis Leptourgos, Charles Fernyhough, Flavie Waters, Frank Larøi, Renaud Jardri, Simon McCarthy-Jones, Neil Thomas, Rob Dudley, John-Paul Taylor, Daniel Collerton, Prabitha Urwyler (2021) <i>Schizophrenia bulletin</i> <i></i> <i></i> 47: 1 237-248<br/>

//publicationslist.org/tobias.nef/refid533 2021-01-29T07:56:05Z

At present, the standard practices for home-based assessments of abnormal movements in Parkinson's disease (PD) are based either on subjective tools or on objective measures that often fail to capture day-to-day fluctuations and long-term information in real-life conditions in a way that patient's compliance and privacy are secured. The employment of wearable technologies in PD represents a great ...<br/><br/>Stefania Ancona, Francesca D Faraci, Elina Khatab, Luigi Fiorillo, Oriella Gnarra, Tobias Nef, Claudio L A Bassetti, Panagiotis Bargiotas (2021) <i>Journal of neurology</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid530 2021-01-29T07:54:17Z

The clinical link between spatial and non-spatial attentional aspects in patients with hemispatial neglect is well known; in particular, an increase in alerting can transitorily help to allocate attention towards the contralesional side. In models of attention, this phenomenon is postulated to rely on an interaction between ventral and dorsal cortical networks, subtending non-spatial and spatial a...<br/><br/>Dario Cazzoli, Brigitte C Kaufmann, Rebecca E Paladini, René M Müri, Tobias Nef, Thomas Nyffeler (2021) <i>Brain communications</i> <i></i> <i></i> 3: 1 <br/>

//publicationslist.org/tobias.nef/refid537 2021-03-01T12:24:45Z

Home monitoring systems are increasingly used to monitor seniors in their apartments for detection of emergency situations. More recently, multimodal ambient sensor systems are also used to monitor digital biomarkers to detect clinically relevant health problems over longer time periods. Clinical signs of HF decompensation including increase of heart rate and respiration rate, decreased physical a...<br/><br/>Hugo Saner, Narayan Schuetz, Philipp Buluschek, Guillaume Du Pasquier, Giuseppe Ribaudo, Prabitha Urwyler, Tobias Nef (2021) <i>Frontiers in cardiovascular medicine</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid540 2021-09-03T09:37:39Z

Non-invasive brain stimulation (NIBS) techniques are widely used in research settings to investigate brain mechanisms and increasingly being used for treatment purposes. The aim of this study was to systematically identify and review the current literature on NIBS studies of limb praxis and apraxia in healthy subjects and stroke patients with a scoping review using PRISMA-ScR guidelines. MEDLINE-P...<br/><br/>Manuela Pastore-Wapp, Thomas Nyffeler, Tobias Nef, Stephan Bohlhalter, Tim Vanbellingen (2021) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 138: 152-164<br/>

//publicationslist.org/tobias.nef/refid543 2021-04-29T08:41:36Z

Spatial neglect has been shown to occur in 17-65% of patients after acute left-hemispheric stroke. One reason for this varying incidence values might be that left-hemispheric stroke is often accompanied by aphasia, which raises difficulties in assessing attention deficits with conventional neuropsychological tests entailing verbal instructions. Video-oculography during free visual exploration (FVE...<br/><br/>Brigitte C Kaufmann, Dario Cazzoli, Monica Koenig-Bruhin, René M Müri, Tobias Nef, Thomas Nyffeler (2021) <i>Frontiers in neuroscience</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid541 2021-06-28T09:56:35Z

Delirium has been long considered as a major contributor to cognitive impairments and increased mortality following a critical illness. Pharmacologic and non-pharmacologic strategies are used against delirium in the intensive care unit (ICU), despite these strategies remaining controversial. Previous studies have shown the feasibility of using virtual reality within the ICU setting, and we propose...<br/><br/>Aileen C Naef, Marie-Madlen Jeitziner, Stephan M Gerber, Béatrice Jenni-Moser, René M Müri, Stephan M Jakob, Tobias Nef, Matthias Hänggi (2021) <i>Trials</i> <i></i> <i></i> 22: 1 <br/>

//publicationslist.org/tobias.nef/refid545 2021-09-03T09:33:35Z

Flow is a subjective psychological state that people report when they are fully involved in an activity to the point of forgetting time and their surrounding except the activity itself. Being in flow during physical/cognitive rehabilitation may have a considerable impact on functional outcome, especially when patients with neurological diseases engage in exercises using robotics, virtual/augmented...<br/><br/>Beatrice Ottiger, Erwin Van Wegen, Katja Keller, Tobias Nef, Thomas Nyffeler, Gert Kwakkel, Tim Vanbellingen (2021) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 18: 1 <br/>

//publicationslist.org/tobias.nef/refid567 2022-03-21T14:04:54Z

Neurorehabilitation research suggests that not only high training intensity, but also somatosensory information plays a fundamental role in the recovery of stroke patients. Yet, there is currently a lack of easy-to-use robotic solutions for sensorimotor hand rehabilitation. We addressed this shortcoming by developing a novel clinical-driven robotic hand rehabilitation device, which is capable of f...<br/><br/>Raphael Rätz, François Conti, René M Müri, Laura Marchal-Crespo (2021) <i>Frontiers in neurorobotics</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid566 2022-03-21T14:04:25Z

Transcranial Direct Current Stimulation (tDCS) has been employed to modulate visuo-spatial attentional asymmetries, however, further investigation is needed to characterize tDCS-associated variability in more ecological settings. In the present research, we tested the effects of offline, anodal conventional tDCS (Experiment 1) and HD-tDCS (Experiment 2) delivered over the posterior parietal cortex...<br/><br/>Lorenzo Diana, Giulia Scotti, Edoardo N Aiello, Patrick Pilastro, Aleksandra K Eberhard-Moscicka, René M Müri, Nadia Bolognini (2021) <i>Brain sciences</i> <i></i> <i></i> 12: 1 <br/>

//publicationslist.org/tobias.nef/refid565 2022-03-21T14:03:45Z

To offer engaging neurorehabilitation training to neurologic patients, motor tasks are often visualized in virtual reality (VR). Recently introduced head-mounted displays (HMDs) allow to realistically mimic the body of the user from a first-person perspective (i.e., avatar) in a highly immersive VR environment. In this immersive environment, users may embody avatars with different body characteris...<br/><br/>Karin A Buetler, Joaquin Penalver-Andres, Özhan Özen, Luca Ferriroli, René M Müri, Dario Cazzoli, Laura Marchal-Crespo (2021) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid570 2022-03-21T14:07:22Z

The use of robots has attracted researchers to design numerous haptic training methods to support motor learning. However, investigations of new methods yielded inconclusive results regarding their effectiveness to enhance learning due to the diversity of tasks, haptic designs, participants' skill level, and study protocols. In this review, we developed a taxonomy to identify generalizable finding...<br/><br/>Ekin Basalp, Peter Wolf, Laura Marchal-Crespo (2021) <i>IEEE transactions on haptics</i> <i></i> <i></i> 14: 4 722-739<br/>

//publicationslist.org/tobias.nef/refid571 2022-03-21T14:08:11Z

Thomas Nyffeler, Brigitte C Kaufmann, Dario Cazzoli (2021) <i>JAMA neurology</i> <i></i> <i></i> 78: 12 1531-1533<br/>

//publicationslist.org/tobias.nef/refid587 2022-10-31T14:16:06Z

Patients with Parkinson's disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL) due to dysfunctional supplementary motor area (SMA). The aim of this clinical trial protocol work is to describe how the effectiveness of a combined repetitive transcranial magnetic stimulation (rTMS) over SMA and video-game-based skill training (VBT) in PD wi...<br/><br/>Manuela Pastore-Wapp, Dirk Lehnick, Tobias Nef, Stephan Bohlhalter, Tim Vanbellingen (2021) <i>Frontiers in rehabilitation sciences</i> <i></i> <i></i> 2: <br/>

//publicationslist.org/tobias.nef/refid551 2021-09-03T09:39:07Z

In Parkinson's disease (PD) patients, visual misperceptions are a major problem within the non-motor symptoms. Pareidolia, i.e., the tendency to perceive a specific, meaningful image in an ambiguous visual pattern, is a phenomenon that occurs also in healthy subjects. Literature suggests that the perception of face pareidolia may be increased in patients with neurodegenerative diseases. We aimed t...<br/><br/>Nicole Göbel, Jens Carsten Möller, Nathalie Hollenstein, Andreas Binder, Matthias Oechsner, Jörg Ide, Prabitha Urwyler, Dario Cazzoli, René M Müri (2021) <i>Frontiers in neurology</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid564 2022-03-21T14:02:41Z

Learning a new motor task is a complex cognitive and motor process. Especially early during motor learning, cognitive functions such as attentional engagement, are essential, e.g., to discover relevant visual stimuli. Drawing participant's attention towards task-relevant stimuli-e.g., with task instructions using visual cues or explicit written information-is a common practice to support cognitive...<br/><br/>Joaquin Penalver-Andres, Karin A Buetler, Thomas Koenig, René Martin Müri, Laura Marchal-Crespo (2021) <i>Frontiers in neuroscience</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid572 2022-03-21T14:09:31Z

This preliminary investigation aimed to assess beta (β) oscillation, a marker of the brain GABAergic signaling, as a potential objective pain marker, hence contributing at the same time to the mechanistic approach of pain management. This case-control observational study measured β electroencephalographic (EEG) oscillation in 12 right-handed adult male with chronic neuropathic pain and 10 matche...<br/><br/>Micael Teixeira, Christian Mancini, Corentin Aurèle Wicht, Gianluca Maestretti, Thierry Kuntzer, Dario Cazzoli, Michael Mouthon, Jean-Marie Annoni, Joelle Nsimire Chabwine (2021) <i>Frontiers in neuroscience</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid552 2021-09-03T09:39:39Z

Theta burst stimulation (TBS) is a non-invasive brain stimulation method. Various stimulation protocols have been proposed, for instance, stimulation at 50 Hz with pattern at 5 Hz, or at 30 Hz with pattern at 6 Hz. To identify better stimulation parameters for behavioral applications, we investigated the effects of 50-Hz continuous TBS (cTBS) on the sense of agency (SoA), and compared them with a ...<br/><br/>Giuseppe A Zito, Yulia Worbe, Jean-Charles Lamy, Joel Kälin, Janine Bühler, Samantha Weber, René M Müri, Selma Aybek (2021) <i>Frontiers in neuroscience</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid553 2022-03-21T14:08:53Z

When humans visually explore an image, they typically tend to start exploring its left side. This phenomenon, so-called pseudoneglect, is well known, but its time-course has only sparsely been studied. Furthermore, it is unclear whether age influences pseudoneglect, and the relationship between visuo-spatial attentional asymmetries in a free visual exploration task and a classical line bisection t...<br/><br/>Kathrin Chiffi, Lorenzo Diana, Matthias Hartmann, Dario Cazzoli, Claudio L Bassetti, René M Müri, Aleksandra K Eberhard-Moscicka (2021) <i>Experimental brain research</i> <i></i> <i></i> 239: 9 2693-2700<br/>

//publicationslist.org/tobias.nef/refid562 2022-03-21T14:00:51Z

Modern sensor technology is increasingly used in older adults to not only provide additional safety but also to monitor health status, often by means of sensor derived digital measures or biomarkers. Social isolation is a known risk factor for late-life depression, and a potential component of social-isolation is the lack of home visits. Therefore, home visits may serve as a digital measure for so...<br/><br/>Narayan Schutz, Angela Amira Botros, Sami Ben Hassen, Hugo Saner, Philipp Buluschek, Prabitha Urwyler, Bruno Pais, Valerie Santschi, Daniel Gatica-Perez, Rene M Muri, Tobias Lukas Nef (2021) <i>IEEE journal of biomedical and health informatics</i> <i></i> <i></i> PP: <br/>

//publicationslist.org/tobias.nef/refid561 2022-03-21T14:00:12Z

Gait analysis is an important part of assessments for a variety of health conditions, specifically neurodegenerative diseases. Currently, most methods for gait assessment are based on manual scoring of certain tasks or restrictive technologies. We present an unobtrusive sensor system based on light detection and ranging sensor technology for use in home-like environments. In our evaluation, we com...<br/><br/>Angela Botros, Nathan Gyger, Narayan Schütz, Michael Single, Tobias Nef, Stephan M Gerber (2021) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 21: 18 <br/>

//publicationslist.org/tobias.nef/refid508 2020-07-20T05:21:28Z

Adjustment disorders (AjD) with depressive symptoms following an acquired brain injury (ABI) is a common phenomenon. Although brain injuries are increasing more and more, research on psychological therapies is comparably scarce. The present study compared, by means of a randomized controlled trial (RCT), a newly developed integrative treatment (Standard PLUS) to a standard neuropsychological treat...<br/><br/>Antoine Urech, Tobias Krieger, Eveline Frischknecht, Franziska Stalder-Lüthy, Martin Grosse Holtforth, René Martin Müri, Hansjörg Znoj, Helene Hofer (2020) <i>Journal of clinical medicine</i> <i></i> <i></i> 9: 6 <br/>

//publicationslist.org/tobias.nef/refid507 2020-07-20T05:21:28Z

An amendment to this paper has been published and can be accessed via the original article.<br/><br/>Roman Trepp, Raphaela Muri, Stephanie Abgottspon, Lenka Bosanska, Michel Hochuli, Johannes Slotboom, Christian Rummel, Roland Kreis, Regula Everts (2020) <i>Trials</i> <i></i> <i></i> 21: 1 <br/>

//publicationslist.org/tobias.nef/refid510 2020-08-04T13:26:12Z

Noise levels on intensive care units (ICUs) are typically elevated. While many studies reported negative effects of ICU ambient sounds on patients, only few investigated noise as a factor to influence well-being or performance in healthcare professionals.<br/><br/>Nadine Schmidt, Stephan M Gerber, Björn Zante, Tom Gawliczek, Alvin Chesham, Klemens Gutbrod, René M Müri, Tobias Nef, Joerg C Schefold, Marie-Madlen Jeitziner (2020) <i>Intensive care medicine experimental</i> <i></i> <i></i> 8: 1 <br/>

//publicationslist.org/tobias.nef/refid509 2021-01-29T07:57:21Z

Migraine with aura (MwA) in pediatric patients is clinically frequent. Clinically complex symptoms need to be differentiated to exclude mimicking conditions.<br/><br/>Frauke Kellner-Weldon, Vera Franziska Lehmann, Philipe Sebastian Breiding, Lorenz Grunder, Raphaela Muri, Manuela Pastore-Wapp, Sandra Bigi, Roland Wiest, Marwan El-Koussy, Nedelina Slavova (2020) <i>European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society</i> <i></i> <i></i> 28: 221-227<br/>

//publicationslist.org/tobias.nef/refid511 2020-10-29T08:09:44Z

In recent years, consumer-grade sensors that measure health relevant physiological signals have become widely available and are increasingly used by consumers and researchers alike. While this allows for multiple novel, potentially highly beneficial, large-scale health monitoring applications, quality of these data streams is oftentimes suboptimal. This makes alignment of different high-frequency ...<br/><br/>Narayan Schutz, Angela A Botros, Samuel E J Knobel, Hugo Saner, Philipp Buluschek, Tobias Nef (2020) <i>Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference</i> <i></i> <i></i> 2020: 5858-5962<br/>

//publicationslist.org/tobias.nef/refid514 2020-10-13T12:32:58Z

Outcome measures are key to tailor rehabilitation goals to the stroke patient's individual needs and to monitor poststroke recovery. The large number of available outcome measures leads to high variability in clinical use. Currently, an internationally agreed core set of motor outcome measures for clinical application is lacking. Therefore, the goal was to develop such a set to serve as a quality ...<br/><br/>Johannes Pohl, Jeremia Philipp Oskar Held, Geert Verheyden, Margit Alt Murphy, Stefan Engelter, Agnes Flöel, Thierry Keller, Gert Kwakkel, Tobias Nef, Nick Ward, Andreas Rüdiger Luft, Janne Marieke Veerbeek (2020) <i>Frontiers in neurology</i> <i></i> <i></i> 11: <br/>

//publicationslist.org/tobias.nef/refid513 2020-10-29T08:09:44Z

Spatial attention is an important feature for filtering everyday inputs. The direction of the attention can be guided by the use of visual, auditory or tactile stimuli. The literature regarding the effect of cueing spatial attention in visual search tasks consistently shows an improvement in accuracy and reaction time. So far, most studies have used two-dimensional setups, for which ecological val...<br/><br/>Samuel E J Knobel, Nathan T Gyger, Thomas Nyffeler, Dario Cazzoli, Rene M Muri, Tobias Nef (2020) <i>Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference</i> <i></i> <i></i> 2020: 3192-3195<br/>

//publicationslist.org/tobias.nef/refid512 2020-10-29T08:09:44Z

Pervasive computing based home-monitoring has attracted increasing interest over the past years, especially regarding applications in the growing population of older adults. Applications include safety, monitoring chronic conditions like dementia, or providing preventive information about changes in health and behavior. Commonly used components of such systems are inexpensive and low-power passive...<br/><br/>Angela A Botros, Narayan Schutz, Hugo Saner, Philipp Buluschek, Tobias Nef (2020) <i>Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference</i> <i></i> <i></i> 2020: 5826-5830<br/>

//publicationslist.org/tobias.nef/refid506 2021-01-29T07:54:17Z

Clinical, neuroimaging, and non-invasive brain stimulation studies have associated the dorsolateral prefrontal cortex (DLPFC) with the multilingual language control system. Here, we investigated if this role is increased during the processing of the non-dominant language due to the higher cognitive/attentional demands. We used an inhibitory repetitive transcranial magnetic stimulation (rTMS) proto...<br/><br/>Lea B Jost, Maria I Pestalozzi, Dario Cazzoli, Michael Mouthon, René M Müri, Jean-Marie Annoni (2020) <i>Brain topography</i> <i></i> <i></i> 33: 4 504-518<br/>

//publicationslist.org/tobias.nef/refid503 2020-07-20T05:18:49Z

: Unilateral spatial neglectis an attention disorder frequently occurring after a right-hemispheric stroke. Neglect results in a reduction in qualityof life and performance in activities of daily living. With current technical improvements in virtual reality (VR) technology, trainingwith stereoscopic head-mounted displays (HMD) has become a promising new approach for the assessment and the rehabil...<br/><br/>Samuel E J Knobel, Brigitte C Kaufmann, Stephan M Gerber, Dario Cazzoli, René M Müri, Thomas Nyffeler, Tobias Nef (2020) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 14: <br/>

//publicationslist.org/tobias.nef/refid499 2020-05-29T07:42:59Z

This study investigated the role of the left dorsolateral prefrontal cortex (DLPFC) in language switching using theta burst stimulation (TBS) and electroencephalography in late bilinguals. After a sham-controlled baseline, participants received either excitatory or inhibitory TBS over the left DLPFC before conducting picture naming tasks in pure language blocks and a language switching block, as w...<br/><br/>Maria I Pestalozzi, Jean-Marie Annoni, René M Müri, Lea B Jost (2020) <i>Brain and language</i> <i></i> <i></i> 205: <br/>

//publicationslist.org/tobias.nef/refid498 2021-01-04T12:12:15Z

We developed a standardized, comprehensive, ambulatory, hospital-based neurorehabilitation program ("MS-Fit") to improve disability, activities of daily living and quality of life in people with multiple sclerosis (PwMS).<br/><br/>Isabelle Lehmann, Irène Thaler, Gere Luder, Ulrike Damm, Charlotte Wälti, Saskia Steinheimer, Martin L Verra, Rene M Müri, Thomas Nyffeler, Tim Vanbellingen, Christian P Kamm (2020) <i>European journal of physical and rehabilitation medicine</i> <i></i> <i></i> 56: 3 279-285<br/>

//publicationslist.org/tobias.nef/refid497 2020-05-29T07:42:59Z

The sense of agency is an important aspect of motor control. Impaired sense of agency has been linked to several medical conditions, including schizophrenia and functional neurological disorders. A complex brain network subserves the sense of agency, and the right temporoparietal junction is one of its main nodes. In this paper, we tested whether transcranial magnetic stimulation over the right te...<br/><br/>Giuseppe A Zito, Laura B Anderegg, Kallia Apazoglou, René M Müri, Roland Wiest, Martin Grosse Holtforth, Selma Aybek (2020) <i>Journal of psychiatry & neuroscience : JPN</i> <i></i> <i></i> 45: 4 <br/>

//publicationslist.org/tobias.nef/refid485 2020-05-29T07:38:46Z

There is currently a need for engaging, user-friendly, and repeatable tasks for assessment of cognitive and motor function in aging and neurodegenerative diseases. This study evaluated the feasibility of a maze-like Numberlink puzzle game in assessing differences in game-based measures of cognition and motor function due to age and neurodegenerative diseases. Fifty-five participants, including you...<br/><br/>Tobias Nef, Alvin Chesham, Narayan Schütz, Angela Amira Botros, Tim Vanbellingen, Jean-Marc Burgunder, Julia Müllner, René Martin Müri, Prabitha Urwyler (2020) <i>Frontiers in aging neuroscience</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid500 2020-05-29T07:42:59Z

The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood phenylalanine (Phe) levels in adults outside pregnancy is a matter of debate. Therefore, prospective intervention studies are needed to evaluate the effects of an elevated Phe concentration on cognition and structural, functional, and neuro...<br/><br/>Roman Trepp, Raphaela Muri, Stephanie Abgottspon, Lenka Bosanska, Michel Hochuli, Johannes Slotboom, Christian Rummel, Roland Kreis, Regula Everts (2020) <i>Trials</i> <i></i> <i></i> 21: 1 <br/>

//publicationslist.org/tobias.nef/refid504 2021-06-28T10:07:05Z

Persons with multiple sclerosis (MS) often experience dexterous difficulties during the performance of activities of daily living, such as fastening buttons, handling coins, or writing, therefore impacting their health-related quality of life. Mobile health (mHealth) solutions, such as tablet apps, may be used to train impaired dexterous skills. The feasibility of a tablet app-based dexterity home...<br/><br/>Judith Jantine Willemijn van Beek, Erwin Everardus Henri van Wegen, Marc Berend Rietberg, Thomas Nyffeler, Stephan Bohlhalter, Christian Philipp Kamm, Tobias Nef, Tim Vanbellingen (2020) <i>JMIR mHealth and uHealth</i> <i></i> <i></i> 8: 6 <br/>

//publicationslist.org/tobias.nef/refid495 2020-05-29T07:42:03Z

René M Müri, Dario Cazzoli (2020) <i>JAMA neurology</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid502 2020-05-29T07:42:59Z

The representation and processing of numerosity is a crucial cognitive capacity. Converging evidence points to the posterior parietal cortex (PPC) as primary "number" region. However, the exact role of the left and right PPC for different types of numerical and arithmetic tasks remains controversial. In this study, we used high-definition transcranial direct current stimulation (HD-tDCS) to furthe...<br/><br/>Matthias Hartmann, Sarah Singer, Branislav Savic, René M Müri, Fred W Mast (2020) <i>Journal of cognitive neuroscience</i> <i></i> <i></i> 32: 5 862-876<br/>

//publicationslist.org/tobias.nef/refid505 2021-06-28T10:03:40Z

Neglect after stroke is most accurately diagnosed by a systematic, ecological observation during everyday behaviour using the Catherine Bergego Scale (CBS). However, the CBS is time-consuming and often omitted in clinical settings, especially stroke units. In this study, we aimed to explore if video-oculography during free visual exploration (FVE), which can be performed in few minutes, is sensiti...<br/><br/>Brigitte C Kaufmann, Dario Cazzoli, Tobias Pflugshaupt, Stephan Bohlhalter, Tim Vanbellingen, René M Müri, Tobias Nef, Thomas Nyffeler (2020) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 129: 223-235<br/>

//publicationslist.org/tobias.nef/refid516 2020-10-13T12:32:58Z

The Mean gaze position during free visual exploration (FVE) is a sensitive tool to detect neglect in patients after a right-hemispheric stroke. Here we investigated the test-retest-reliability of mean gaze position during FVE in 23 patients with left-sided neglect after a first-ever sub-acute right-hemispheric stroke. We analyzed the reliability between different test sets administered within 11 d...<br/><br/>Brigitte Charlotte Kaufmann, Dario Cazzoli, René Martin Müri, Tobias Nef, Thomas Nyffeler (2020) <i>Frontiers in neuroscience</i> <i></i> <i></i> 14: <br/>

//publicationslist.org/tobias.nef/refid528 2021-06-28T10:07:05Z

Gestures are an important part of communication. Patients with schizophrenia present gesture deficits that tend to deteriorate in the course of the disease and hamper functional outcome. This gesture deficit has been associated with motor abnormalities, cognitive impairment, and psychotic symptoms. Unaffected, first-degree relatives of schizophrenia patients share some subclinical motor and cognit...<br/><br/>Florian Wüthrich, Anastasia Pavlidou, Katharina Stegmayer, Sarah Eisenhardt, Jeanne Moor, Lea Schäppi, Tim Vanbellingen, Stephan Bohlhalter, Sebastian Walther (2020) <i>Schizophrenia research</i> <i></i> <i></i> 223: 258-264<br/>

//publicationslist.org/tobias.nef/refid527 2021-01-04T12:09:10Z

People with Parkinson's disease (PD) experience not only motor problems but also non-motor problems that seriously impede their daily functioning and quality of life. The current pharmacologic treatment of PD is symptomatic, and alternative rehabilitation treatments, which preferably also have a disease-modifying effect and promote neuroplasticity, are needed. Recent studies suggest that high-inte...<br/><br/>Erwin E H van Wegen, Mark A Hirsch, Wilma D J van de Berg, Chris Vriend, Marc B Rietberg, Mark A Newman, Tim Vanbellingen, Odile A van den Heuvel (2020) <i>Frontiers in neurology</i> <i></i> <i></i> 11: <br/>

//publicationslist.org/tobias.nef/refid526 2021-01-04T12:09:10Z

Cognitive estimation is a mental ability applied to solve numerical problems when precise facts are unknown, unavailable or impractical to calculate. It has been associated with several underlying cognitive components, most often with executive functions and semantic memory. Little is known about the neural correlates of cognitive estimation. To address this issue, the present cross-sectional stud...<br/><br/>Tobias Pflugshaupt, Daniel Bauer, Julia Frey, Tim Vanbellingen, Brigitte C Kaufmann, Stephan Bohlhalter, Thomas Nyffeler (2020) <i>Brain communications</i> <i></i> <i></i> 2: 2 <br/>

//publicationslist.org/tobias.nef/refid529 2021-01-04T12:10:22Z

In October 2019, a Swiss panel of experts met for the Dementia Summit in Brunnen, Switzerland, to discuss the latest scientific findings on basic and clinical research, as well as practical and political approaches to the challenges of dementia disorders in Switzerland. Here, we present the conference summary. To study pathophysiological changes, as well as the underlying mechanism of fluid biomar...<br/><br/>Thomas Leyhe, Mathias Jucker, Tobias Nef, Marc Sollberger, Florian Riese, Jose Haba-Rubio, Henk Verloo, Regula Lüthi, Stefanie Becker, Julius Popp (2020) <i>Swiss medical weekly</i> <i></i> <i></i> 150: <br/>

//publicationslist.org/tobias.nef/refid538 2021-03-01T12:26:36Z

Despite recent advances in robot-assisted training, the benefits of haptic guidance on motor (re)learning are still limited. While haptic guidance may increase task performance during training, it may also decrease participants' effort and interfere with the perception of the environment dynamics, hindering somatosensory information crucial for motor learning. Importantly, haptic guidance limits m...<br/><br/>Özhan Özen, Karin A Buetler, Laura Marchal-Crespo (2020) <i>Frontiers in neuroscience</i> <i></i> <i></i> 14: <br/>

//publicationslist.org/tobias.nef/refid560 2022-03-21T13:59:40Z

Passive infrared motion sensors are commonly used in telemonitoring applications to monitor older community-dwelling adults at risk. One possible use case is quantification of in-home physical activity, a key factor and potential digital biomarker for healthy and independent aging. A major disadvantage of passive infrared sensors is their lack of performance and comparability in physical activity ...<br/><br/>Narayan Schütz, Hugo Saner, Angela Botros, Philipp Buluschek, Prabitha Urwyler, René M Müri, Tobias Nef (2020) <i>Frontiers in digital health</i> <i></i> <i></i> 2: <br/>

//publicationslist.org/tobias.nef/refid542 2021-03-29T10:49:26Z

Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear although visual evoked potenti...<br/><br/>Nicholas Murphy, Alison Killen, Rajnish Kumar Gupta, Sara Graziadio, Lynn Rochester, Michael Firbank, Mark R Baker, Charlotte Allan, Daniel Collerton, John-Paul Taylor, Prabitha Urwyler (2020) <i>Frontiers in neurology</i> <i></i> <i></i> 11: <br/>

//publicationslist.org/tobias.nef/refid525 2021-01-04T12:09:10Z

Discharge planning of stroke patients during inpatient neurorehabilitation is often difficult since it depends both on the patient's ability to perform activities of daily living (ADL) and the social context. The aim of this study was to define ADL cut-off scores using the Lucerne ICF-based multidisciplinary observation scale (LIMOS) that allow the clinicians to decide whether stroke patients who ...<br/><br/>Beatrice Ottiger, Dirk Lehnick, Tobias Pflugshaupt, Tim Vanbellingen, Thomas Nyffeler (2020) <i>Frontiers in neurology</i> <i></i> <i></i> 11: <br/>

//publicationslist.org/tobias.nef/refid536 2021-01-29T08:13:32Z

Visual hallucinations are common in older people and are especially associated with ophthalmological and neurological disorders, including dementia and Parkinson's disease. Uncertainties remain whether there is a single underlying mechanism for visual hallucinations or they have different disease-dependent causes. However, irrespective of mechanism, visual hallucinations are difficult to treat. Th...<br/><br/>John O'Brien, John Paul Taylor, Clive Ballard, Roger A Barker, Clare Bradley, Alistair Burns, Daniel Collerton, Sonali Dave, Rob Dudley, Paul Francis, Andrea Gibbons, Kate Harris, Vanessa Lawrence, Iracema Leroi, Ian McKeith, Michel Michaelides, Chaitali Naik, Claire O'Callaghan, Kirsty Olsen, Marco Onofrj, Rebecca Pinto, Gregor Russell, Peter Swann, Alan Thomas, Prabitha Urwyler, Rimona Sharon Weil, Dominic Ffytche (2020) <i>Journal of neurology, neurosurgery, and psychiatry</i> <i></i> <i></i> 91: 5 512-519<br/>

//publicationslist.org/tobias.nef/refid519 2021-06-28T10:02:57Z

Hand gestures are an integral part of social interactions and communication. Several imaging studies in healthy subjects and lesion studies in patients with apraxia suggest the praxis network for gesture production, involving mainly left inferior frontal, posterior parietal and temporal regions. However, little is known about the structural connectivity underlying gesture production. We recruited ...<br/><br/>Petra V Viher, Ahmed Abdulkadir, Peter Savadijev, Katharina Stegmayer, Marek Kubicki, Nikos Makris, Sarina Karmacharya, Andrea Federspiel, Stephan Bohlhalter, Tim Vanbellingen, René Müri, Roland Wiest, Werner Strik, Sebastian Walther (2020) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 132: 322-333<br/>

//publicationslist.org/tobias.nef/refid518 2020-10-13T12:32:58Z

Tim Vanbellingen, Judith van Beek, Thomas Nyffeler, Prabitha Urwyler, Tobias Nef, Stephan Bohlhalter (2020) <i>Annals of physical and rehabilitation medicine</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid524 2020-11-30T10:55:00Z

Population aging is increasing the needs and costs of healthcare. Both frailty and the chronic diseases affecting older people reduce their ability to live independently. However, most older people prefer to age in their own homes. New development of in-home monitoring can play a role in staying independent, active, and healthy for older people. This 12-month observational study aimed to evaluate ...<br/><br/>Bruno Pais, Philipp Buluschek, Guillaume DuPasquier, Tobias Nef, Narayan Schütz, Hugo Saner, Daniel Gatica-Perez, Valérie Santschi (2020) <i>Frontiers in public health</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid520 2020-10-13T12:34:39Z

Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to their level of oxygenation. Our study aimed at evaluating the frequency of regions of prominent focal veins (PF...<br/><br/>Frauke Kellner-Weldon, Marina Jossen, Philipe S Breiding, Lorenz Grunder, Christoph Schankin, Adrian Scutelnic, Urs Fischer, Raphaela Muri, Manuela Pastore-Wapp, Roland Wiest, Marwan El-Koussy (2020) <i>Clinical neuroradiology</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid517 2020-10-13T12:32:58Z

Home monitoring sensor systems are increasingly used to monitor seniors in their apartments for detection of emergency situations. The aim of this study was to deliver a proof-of-concept for the use of multimodal sensor systems with pervasive computing technology for the detection of clinically relevant health problems over longer time periods. Data were collected with a longitudinal home monitor...<br/><br/>Hugo Saner, Narayan Schütz, Angela Botros, Prabitha Urwyler, Philipp Buluschek, Guillaume du Pasquier, Tobias Nef (2020) <i>Frontiers in cardiovascular medicine</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid521 2020-10-29T08:12:13Z

Pneumococcal meningitis (PM) causes damage to the hippocampus, a brain structure critically involved in learning and memory. Hippocampal injury-which compromises neurofunctional outcome-occurs as apoptosis of progenitor cells and immature neurons of the hippocampal dentate granule cell layer thereby impairing the regenerative capacity of the hippocampal stem cell niche. Repetitive transcranial mag...<br/><br/>Lukas Muri, Simone Oberhänsli, Michelle Buri, Ngoc Dung Le, Denis Grandgirard, Rémy Bruggmann, René M Müri, Stephen L Leib (2020) <i>PloS one</i> <i></i> <i></i> 15: 9 <br/>

//publicationslist.org/tobias.nef/refid523 2021-03-29T10:48:03Z

Isometric strength measures and timed up and go (TUG) tests are both recognized as valuable tools for fall prediction in older adults. However, results from direct comparison of these two tests are lacking. We aimed to assess the potential of isometric strength measures and the different modalities of the TUG test to detect individuals at risk of falling.<br/><br/>Pedro L Valenzuela, Nicola A Maffiuletti, Hugo Saner, Narayan Schütz, Beatrice Rudin, Tobias Nef, Prabitha Urwyler (2020) <i>Clinical interventions in aging</i> <i></i> <i></i> 15: 2001-2008<br/>

//publicationslist.org/tobias.nef/refid522 2021-03-29T10:48:03Z

Aphasia is a common language disorder acquired after stroke that reduces the quality of life of affected patients. The impairment is frequently accompanied by a deficit in cognitive functions. The state-of-the-art therapy is speech and language therapy but recent findings highlight positive effects of high-frequency therapy. Telerehabilitation has the potential to enable high-frequency therapy for...<br/><br/>Arif Sinan Uslu, Stephan M Gerber, Nadine Schmidt, Carina Röthlisberger, Patric Wyss, Tim Vanbellingen, Sandra Schaller, Corina Wyss, Monica Koenig-Bruhin, Thomas Berger, Thomas Nyffeler, René Müri, Tobias Nef, Prabitha Urwyler (2020) <i>BMJ open</i> <i></i> <i></i> 10: 11 <br/>

//publicationslist.org/tobias.nef/refid474 2019-06-26T13:37:52Z

Traumatic brain injury (TBI) and its potential long-term consequences are of major concern for public health. Neurorehabilitation of affected individuals has some specific characteristics in contrast to neurorehabilitation of patients with acquired brain lesions of other aetiology. This review will deal with the clinical consequences of the distinct lesions of TBI. In severe TBI, clinical course o...<br/><br/>Michael Oberholzer, René M Müri (2019) <i>Medical sciences (Basel, Switzerland)</i> <i></i> <i></i> 7: 3 <br/>

//publicationslist.org/tobias.nef/refid473 2019-06-26T13:37:52Z

Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Chiffi, Aleksandra K Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René M Müri, Reto Huber, Marcello Massimini, Claudio Bassetti (2019) <i>Journal of neuroscience methods</i> <i></i> <i></i> 321: <br/>

//publicationslist.org/tobias.nef/refid472 2019-06-26T13:35:16Z

Brigitte C Kaufmann, Manuela Pastore-Wapp, Maria Lübeck, Monica Koenig, Stephan Bohlhalter, Tim Vanbellingen, Dario Cazzoli, Thomas Nyffeler (2019) <i>Brain stimulation</i> <i></i> <i></i> 12: 4 1069-1071<br/>

//publicationslist.org/tobias.nef/refid475 2019-06-26T13:37:52Z

Humankind faces a plethora of environmental problems, many of which are directly influenced by individual human behaviour. To better understand pro-environmental behaviour, we here try to identify interindividual markers that explain variance in the frequency of every-day pro-environmental behaviour. So far, research on this topic has mainly relied on subjective self-report measures and has yielde...<br/><br/>Thomas Baumgartner, Benedikt P Langenbach, Lorena R R Gianotti, René M Müri, Daria Knoch (2019) <i>Scientific reports</i> <i></i> <i></i> 9: 1 <br/>

//publicationslist.org/tobias.nef/refid476 2019-06-26T13:37:52Z

Our own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decades of experimental research have highlighted which aspects and mechanisms of sleep are likely to underlie these forms of recovery. Conversely, damage to certa...<br/><br/>Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Chiffi, Aleksandra K Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René M Müri, Reto Huber, Marcello Massimini, Claudio Bassetti (2019) <i>Journal of neuroscience methods</i> <i></i> <i></i> 313: 37-43<br/>

//publicationslist.org/tobias.nef/refid471 2019-06-26T13:34:31Z

Robotic algorithms that augment movement errors have been proposed as promising training strategies to enhance motor learning and neurorehabilitation. However, most research effort has focused on rehabilitation of upper limbs, probably because large movement errors are especially dangerous during gait training, as they might result in stumbling and falling. Furthermore, systematic large movement e...<br/><br/>Laura Marchal-Crespo, Panagiotis Tsangaridis, David Obwegeser, Serena Maggioni, Robert Riener (2019) <i>Frontiers in neuroscience</i> <i></i> <i></i> 13: <br/>

//publicationslist.org/tobias.nef/refid480 2020-05-29T07:38:46Z

The ageing of the Swiss population is increasing the healthcare needs and costs. Both frailty and chronic diseases affecting older people reduce their ability to live independently. However, the vast majority of older people want to continue living at home, while having a quality of life and receiving the best healthcare services. In this context, new connected healthcare technologies can be a rel...<br/><br/>Bruno Pais, Philipp Buluschek, Tobias Nef, Narayan Schütz, Hugo Saner, Daniel Gatica, Valérie Santschi (2019) <i>Revue medicale suisse</i> <i></i> <i></i> 15: 658 1407-1411<br/>

//publicationslist.org/tobias.nef/refid467 2019-06-26T13:33:16Z

Aphasia is the loss or impairment of language functions and affects everyday social life. The disorder leads to the inability to understand and be understood in both written and verbal communication and affects the linguistic modalities of auditory comprehension, verbal expression, reading, and writing. Due to heterogeneity of the impairment, therapy must be adapted individually and dynamically to...<br/><br/>Stephan Moreno Gerber, Narayan Schütz, Arif Sinan Uslu, Nadine Schmidt, Carina Röthlisberger, Patric Wyss, Sandra Perny, Corina Wyss, Monica Koenig-Bruhin, Prabitha Urwyler, Thomas Nyffeler, Laura Marchal-Crespo, Urs Peter Mosimann, René Martin Müri, Tobias Nef (2019) <i>JMIR rehabilitation and assistive technologies</i> <i></i> <i></i> 6: 1 <br/>

//publicationslist.org/tobias.nef/refid465 2019-06-26T13:33:16Z

To provide an updated review article studying the applicability and effectiveness of sensor networks in measuring and supporting activities of daily living (ADLs) among non-demented older adults.<br/><br/>Eric Lenouvel, Lan Novak, Tobias Nef, Stefan Klöppel (2019) <i>The Gerontologist</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid464 2019-06-26T13:37:52Z

Previous studies showed that the small leftward bias found in healthy humans' spatial judgments of lines ("pseudoneglect") shifts to the right with increasing distance between stimuli and observer. In this study, we investigated whether such a modulation of attentional asymmetry can also be observed in free visual exploration. Participants freely explored photographs of naturalistic scenes for 7â€...<br/><br/>Matthias Hartmann, Nils R Sommer, Lorenzo Diana, René M Müri, Aleksandra K Eberhard-Moscicka (2019) <i>Brain and cognition</i> <i></i> <i></i> 129: 40-48<br/>

//publicationslist.org/tobias.nef/refid481 2020-05-29T07:38:46Z

There is increasing interest in using virtual reality (VR) in robotic neurorehabilitation. However, the use of conventional VR displays (i.e., computer screens), implies several transformations between the real movements in 3D and their 2D virtual representations that might negatively impact the rehabilitation interventions. In this study, we compared the impact on movement quality and cognitive l...<br/><br/>Nicolas Wenk, Joaquin Penalver-Andres, Rara Palma, Karin A Buetler, Rene Muri, Tobias Nef, Laura Marchal-Crespo (2019) <i>IEEE ... International Conference on Rehabilitation Robotics : [proceedings]</i> <i></i> <i></i> 2019: 1037-1042<br/>

//publicationslist.org/tobias.nef/refid466 2019-06-26T13:33:16Z

Visual search declines with aging, dementia, and brain injury and is linked to limitations in everyday activities. Recent studies suggest that visual search can be improved with practice using computerized visual search tasks and puzzle video games. For practical use, it is important that visual search ability can be assessed and practiced in a controlled and adaptive way. However, commercial puzz...<br/><br/>Alvin Chesham, Stephan Moreno Gerber, Narayan Schütz, Hugo Saner, Klemens Gutbrod, René Martin Müri, Tobias Nef, Prabitha Urwyler (2019) <i>JMIR serious games</i> <i></i> <i></i> 7: 2 <br/>

//publicationslist.org/tobias.nef/refid469 2020-05-29T07:42:03Z

Spatial neglect is a strong and negative predictor of general functional outcome after stroke, and its therapy remains a challenge. Whereas inhibitory non-invasive brain stimulation over the contralesional, intact hemisphere has generally been shown to ameliorate neglect on a group level, a conspicuous variability of the effects at the individual level is typically observed. We aimed to assess the...<br/><br/>Thomas Nyffeler, Tim Vanbellingen, Brigitte C Kaufmann, Tobias Pflugshaupt, Daniel Bauer, Julia Frey, Magdalena Chechlacz, Stephan Bohlhalter, René M Müri, Tobias Nef, Dario Cazzoli (2019) <i>Brain : a journal of neurology</i> <i></i> <i></i> 142: 4 992-1008<br/>

//publicationslist.org/tobias.nef/refid468 2019-06-26T13:33:16Z

Falls are the primary contributors of accidents in elderly people. An important factor of fall severity is the amount of time that people lie on the ground. To minimize consequences through a short reaction time, the motion sensor "AIDE-MOI" was developed. "AIDE-MOI" senses acceleration data and analyzes if an event is a fall. The threshold-based fall detection algorithm was developed using motion...<br/><br/>Simon Scheurer, Janina Koch, Martin Kucera, Hȧkon Bryn, Marcel Bärtschi, Tobias Meerstetter, Tobias Nef, Prabitha Urwyler (2019) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 19: 6 <br/>

//publicationslist.org/tobias.nef/refid470 2020-05-29T07:42:03Z

The literature suggests that neglect patients not only show impairments in directing attention toward the left, contralesional space, but also present with perseverative behavior. Moreover, previous studies described re-fixations during visual search tasks, and interpreted this finding as an impairment of spatial working memory. The aim of the present study was to study re-fixations and perseverat...<br/><br/>Rebecca E Paladini, Patric Wyss, Brigitte C Kaufmann, Prabitha Urwyler, Tobias Nef, Dario Cazzoli, Thomas Nyffeler, René M Müri (2019) <i>The European journal of neuroscience</i> <i></i> <i></i> 49: 10 1244-1253<br/>

//publicationslist.org/tobias.nef/refid515 2020-10-13T12:32:58Z

Leg-press devices are one of the most widely used training tools for musculoskeletal strengthening of the lower-limbs, and have demonstrated important cardiopulmonary benefits for healthy and patient populations. Further engineering development was done on a dynamic leg-press for work-rate estimation by integrating force and motion sensors, power calculation and a visual feedback system for voliti...<br/><br/>Farouk Chrif, Tobias Nef, Kenneth J Hunt (2019) <i>BMC biomedical engineering</i> <i></i> <i></i> 1: <br/>

//publicationslist.org/tobias.nef/refid490 2020-05-29T07:40:23Z

Research into hallucinations typically regards them as single sensory or unimodal experiences leading to a comparative neglect of co-occurring multi-sensory hallucinations (MSH). People with psychosis who have visual hallucinations (VH) report high rates of hallucinations in other senses (auditory, olfactory, tactile). However, it is not known if this is similar to other groups who report VH. Cons...<br/><br/>R Dudley, C Aynsworth, U Mosimann, J-P Taylor, D Smailes, D Collerton, S McCarthy-Jones, P Urwyler (2019) <i>Psychiatry research</i> <i></i> <i></i> 272: 86-92<br/>

//publicationslist.org/tobias.nef/refid489 2020-05-29T07:38:46Z

Parkinson's disease (PD) is characterized by a highly individual disease-profile as well as fluctuating symptoms. Consequently, 24-h home monitoring in a real-world environment would be an ideal solution for precise symptom diagnostics. In recent years, small lightweight sensors which have assisted in objective, reliable analysis of motor symptoms have attracted a lot of attention. While technical...<br/><br/>Angela Botros, Narayan Schütz, Martin Camenzind, Prabitha Urwyler, Daniel Bolliger, Tim Vanbellingen, Rolf Kistler, Stephan Bohlhalter, Rene M Müri, Urs P Mosimann, Tobias Nef (2019) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 19: 23 <br/>

//publicationslist.org/tobias.nef/refid493 2020-05-29T07:41:24Z

One key question in motor learning is how the complex tasks in daily life - those that require coordinated movements of multiple joints - should be trained. Often, complex tasks are directly taught as a whole, even though training of simple movement components before training the entire movement has been shown to be more effective for particularly complex tasks ("part-whole transfer paradigm"). Th...<br/><br/>Joaquin Penalver-Andres, Jaime Duarte, Heike Vallery, Verena Klamroth-Marganska, Robert Riener, Laura Marchal-Crespo, Georg Rauter (2019) <i>IEEE ... International Conference on Rehabilitation Robotics : [proceedings]</i> <i></i> <i></i> 2019: 1085-1090<br/>

//publicationslist.org/tobias.nef/refid494 2020-05-29T07:41:24Z

Motivation plays a crucial role in motor learning and neurorehabilitation. Participants' motivation could decline to a point where they may stop training when facing a very difficult task. Conversely, participants may perform well and consider the training boring if the task is too easy. In this paper, we present a combination of a virtual reality environment with different robotic training strate...<br/><br/>Fabio Bernardoni, Ozhan Ozen, Karin Buetler, Laura Marchal-Crespo (2019) <i>IEEE ... International Conference on Rehabilitation Robotics : [proceedings]</i> <i></i> <i></i> 2019: 760-765<br/>

//publicationslist.org/tobias.nef/refid482 2020-05-29T07:38:46Z

One of the main challenges in robotic neuroreha-bilitation is to understand how robots should physically interact with trainees to optimize motor leaning. There is evidence that motor exploration (i.e., the active exploration of new motor tasks) is crucial to boost motor learning. Furthermore, effectiveness of a robotic training strategy depends on several factors, such as task type and trainee's ...<br/><br/>Ozhan Ozen, Flavio Traversa, Sofiane Gadi, Karin A Buetler, Tobias Nef, Laura Marchal-Crespo (2019) <i>IEEE ... International Conference on Rehabilitation Robotics : [proceedings]</i> <i></i> <i></i> 2019: 754-759<br/>

//publicationslist.org/tobias.nef/refid531 2021-01-29T07:55:14Z

Although robot-assisted training is present in various fields such as sports engineering and rehabilitation, provision of training strategies that optimally support individual motor learning remains as a challenge. Literature has shown that guidance strategies are useful for beginners, while skilled trainees should benefit from challenging conditions. The Challenge Point Theory also supports this ...<br/><br/>Ekin Basalp, Laura Marchal-Crespo, Georg Rauter, Robert Riener, Peter Wolf (2019) <i>Frontiers in robotics and AI</i> <i></i> <i></i> 6: <br/>

//publicationslist.org/tobias.nef/refid488 2020-05-29T07:38:46Z

Newly acquired long-term cognitive impairments are common among survivors of critical illness. They have been linked to the stressful situation that patients experience in the intensive care unit (ICU). In this paper we use virtual reality (VR) technology to comfort critically ill patients and reduce stress during their ICU stay. We investigate the acceptance, comfort, recollection, and visual per...<br/><br/>Stephan M Gerber, Marie-Madlen Jeitziner, Samuel E J Knobel, Urs P Mosimann, René M Müri, Stephan M Jakob, Tobias Nef (2019) <i>Frontiers in medicine</i> <i></i> <i></i> 6: <br/>

//publicationslist.org/tobias.nef/refid496 2021-01-29T07:54:17Z

Intergenerational sustainability is probably humankind's most pressing challenge, exacerbated by the fact that the present generation has to incur costs in order to benefit future generations. However, people often fail to restrict their consumption, despite reporting strong pro-environmental attitudes. Recent theorising sees self-control processes as key component of sustainable decision-making a...<br/><br/>Benedikt P Langenbach, Thomas Baumgartner, Dario Cazzoli, René M Müri, Daria Knoch (2019) <i>Scientific reports</i> <i></i> <i></i> 9: 1 <br/>

//publicationslist.org/tobias.nef/refid532 2021-01-29T07:55:14Z

After a prolonged intensive care unit (ICU) stay, approximately 50%-75% of all critically ill patients suffer from neurocognitive late effects and a reduction of health-related quality of life. It is assumed that the noisy and stressful ICU environment leads to sensory overload and deprivation and potentially to long-term cognitive impairment.<br/><br/>Stephan M Gerber, Marie-Madlen Jeitziner, Simon D Sänger, Samuel E J Knobel, Laura Marchal-Crespo, René M Müri, Joerg C Schefold, Stephan M Jakob, Tobias Nef (2019) <i>JMIR perioperative medicine</i> <i></i> <i></i> 2: 2 <br/>

//publicationslist.org/tobias.nef/refid487 2020-05-29T07:38:46Z

In healthy individuals, increasing cognitive load induces an asymmetric deployment of visuospatial attention, which favors the right visual space. To date, the neural mechanisms of this left/right attentional asymmetry are poorly understood. The aim of the present study was thus to investigate whether a left/right asymmetry under high cognitive load is due to a shift in the interhemispheric balanc...<br/><br/>Rebecca E Paladini, Fluri A M Wieland, Lien Naert, Mario Bonato, Urs P Mosimann, Tobias Nef, René M Müri, Thomas Nyffeler, Dario Cazzoli (2019) <i>Frontiers in neuroscience</i> <i></i> <i></i> 13: <br/>

//publicationslist.org/tobias.nef/refid483 2021-01-29T07:53:34Z

In older adults, physical activity is crucial for healthy aging and associated with numerous health indicators and outcomes. Regular assessments of physical activity can help detect early health-related changes and manage physical activity targeted interventions. The quantification of physical activity, however, is difficult as commonly used self-reported measures are biased and rather unprecise p...<br/><br/>Narayan Schütz, Hugo Saner, Beatrice Rudin, Angela Botros, Bruno Pais, Valérie Santschi, Philipp Buluschek, Daniel Gatica-Perez, Prabitha Urwyler, Laura Marchal-Crespo, René M Müri, Tobias Nef (2019) <i>Scientific reports</i> <i></i> <i></i> 9: 1 <br/>

//publicationslist.org/tobias.nef/refid486 2020-05-29T07:38:46Z

Video-oculography during free visual exploration (FVE) is a valuable tool to evaluate visual attention spatial allocation in neglect patients after right-hemispheric stroke. In conventional FVE analyses, the position of a visual fixation is conceived as a single point in space. Here, we describe a new complementary method to analyze FVE data based on foveal vision, leading to an accurate estimate ...<br/><br/>Brigitte Charlotte Kaufmann, Samuel Elia Johannes Knobel, Tobias Nef, René Martin Müri, Dario Cazzoli, Thomas Nyffeler (2019) <i>Frontiers in neuroscience</i> <i></i> <i></i> 13: <br/>

//publicationslist.org/tobias.nef/refid484 2019-09-27T06:06:37Z

The incidental acquisition of a succession of tasks is termed implicit task sequence learning. Patients with dorsolateral prefrontal cortex (DLPFC) lesions are strongly impaired in this ability. However, recent results of conventional transcranial direct current stimulation (tDCS) above the prefrontal cortex showed no modulation of implicit task sequence learning and consolidation. One explanation...<br/><br/>Branislav Savic, René Müri, Beat Meier (2019) <i>Neuroscience</i> <i></i> <i></i> 414: 77-87<br/>

//publicationslist.org/tobias.nef/refid444 2018-04-24T12:57:31Z

Leg-press machines are widely employed for musculoskeletal conditioning of the lower-limbs and they provide cardiovascular benefits for resistance training in cardiac patients. The aim of this study was to assess the feasibility of a dynamic leg press (DLP) for incremental cardiopulmonary exercise testing (CPET) and to compare the results with those obtained using a cycle ergometer (CE).<br/><br/>Farouk Chrif, Tobias Nef, Kenneth J Hunt (2018) <i>BMC sports science, medicine & rehabilitation</i> <i></i> <i></i> 10: <br/>

//publicationslist.org/tobias.nef/refid445 2019-06-26T13:35:17Z

Deficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of the presen...<br/><br/>B C Kaufmann, J Frey, T Pflugshaupt, P Wyss, R E Paladini, T Vanbellingen, S Bohlhalter, M Chechlacz, T Nef, R M Müri, D Cazzoli, T Nyffeler (2018) <i>Neuropsychologia</i> <i></i> <i></i> 115: 42-50<br/>

//publicationslist.org/tobias.nef/refid446 2018-04-24T12:59:52Z

To investigate, in two separate studies, whether amnesic patients with a severe memory impairment can learn to perform a habitual prospective memory task when they receive immediate feedback on prospective memory failures (Study 1) and whether amnesic patients are able to benefit from previous habitual prospective memory performance after a 24-h retention interval.<br/><br/>Beat Meier, Severin Fanger, Giannina Toller, Sibylle Matter, René Müri, Klemens Gutbrod (2018) <i>The Clinical neuropsychologist</i> <i></i> <i></i> : 1-16<br/>

//publicationslist.org/tobias.nef/refid448 2019-06-26T13:35:17Z

Visual attention allows the allocation of limited neural processing resources to stimuli based on their behavioral priorities. The selection of task-relevant visual targets entails the processing of multiple competing stimuli and the suppression of distractors that may be either perceptually salient or perceptually similar to targets. The posterior parietal cortex controls the interaction between ...<br/><br/>Magdalena Chechlacz, Peter C Hansen, Joy J Geng, Dario Cazzoli (2018) <i>Journal of cognitive neuroscience</i> <i></i> <i></i> 30: 6 851-866<br/>

//publicationslist.org/tobias.nef/refid450 2019-06-26T13:33:16Z

To validate a purpose-built two-coloured chewing gum (Hue-Check Gum ), and to test the accuracy of a custom-built smartphone application for a colour-mixing ability test to assess chewing function.<br/><br/>Ramona Buser, Valerie Ziltener, Stefanie Samietz, Marta Fontolliet, Tobias Nef, Martin Schimmel (2018) <i>Journal of oral rehabilitation</i> <i></i> <i></i> 45: 11 845-853<br/>

//publicationslist.org/tobias.nef/refid451 2018-09-13T12:25:09Z

The role of nonverbal communication in patients with post-stroke language impairment (aphasia) is not yet fully understood. This study investigated how aphasic patients perceive and produce co-speech gestures during face-to-face interaction, and whether distinct brain lesions would predict the frequency of spontaneous co-speech gesturing. For this purpose, we recorded samples of conversations in p...<br/><br/>Basil C Preisig, Noëmi Eggenberger, Dario Cazzoli, Thomas Nyffeler, Klemens Gutbrod, Jean-Marie Annoni, Jurka R Meichtry, Tobias Nef, René M Müri (2018) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid452 2019-06-26T13:34:31Z

To promote motor learning, robotic devices have been used to improve subjects' performance by guiding desired movements (haptic guidance-HG) or by artificially increasing movement errors to foster a more rapid learning (error amplification-EA). To better understand the neurophysiological basis of motor learning, a few studies have evaluated brain regions activated during EA/HG, but none has compar...<br/><br/>Marie-Hélène Milot, Laura Marchal-Crespo, Louis-David Beaulieu, David J Reinkensmeyer, Steven C Cramer (2018) <i>Experimental brain research</i> <i></i> <i></i> 236: 11 3085-3099<br/>

//publicationslist.org/tobias.nef/refid432 2018-09-13T12:26:36Z

This chapter presents an overview of different addictive and obsessive-compulsive symptoms and their constellations due to focal brain lesions. In general, such symptoms are not systematically reported in the literature, and the knowledge about the networks involved is sometimes sparse. Finally, we present an original case with an unusual combination of kleptomania and hyper-religiosity.<br/><br/>René M Müri, Dario Cazzoli (2018) <i>Frontiers of neurology and neuroscience</i> <i></i> <i></i> 41: 61-70<br/>

//publicationslist.org/tobias.nef/refid447 2018-06-25T13:25:08Z

Common sequelae of subarachnoid hemorrhage (SAH) include somatic and/or cognitive impairment. This can cause emotional stress, social tensions, and difficulties in relationships. To test our hypothesis that more severe somatic and cognitive impairments increased the likelihood of disruption of a relationship after SAH, we assessed the integrity of marriage or partnership status in a well-evaluated...<br/><br/>Daniel Schöni, Lara Lauber, Christian Fung, Johannes Goldberg, René Müri, Andreas Raabe, Thomas Nyffeler, Jürgen Beck (2018) <i>World neurosurgery</i> <i></i> <i></i> 113: e161-e165<br/>

//publicationslist.org/tobias.nef/refid462 2021-05-31T08:55:57Z

Quantitative assessment of the muscle tone is important when studying patients with neurological disorders such as Parkinson's disease (PD). For the assessment of therapeutic progress, quantitative and objective outcome measures are needed. This article presents a novel electromechanical device to monitor the quantitative rigidity of the wrist joint against passive movement. The novel device is eq...<br/><br/>Giuseppe A Zito, Stephan M Gerber, Prabitha Urwyler, Mohammad J Shamsollahi, Natassja Pal, David Benninger, Tobias Nef (2018) <i>Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference</i> <i></i> <i></i> 2018: 4885-4888<br/>

//publicationslist.org/tobias.nef/refid477 2019-06-26T13:42:00Z

Translation is a demanding process during which a message is analyzed, translated and communicated from one language to another. Despite numerous studies on translation mechanisms, the electrophysiological processes underlying translation with overt production remain largely unexplored. Here, we investigated how behavioral response patterns and spatial-temporal brain dynamics differ in a translati...<br/><br/>Lea B Jost, Narges Radman, Karin A Buetler, Jean-Marie Annoni (2018) <i>Neuropsychologia</i> <i></i> <i></i> 109: 245-254<br/>

//publicationslist.org/tobias.nef/refid438 2018-04-24T12:57:31Z

Cross-modal spatial cueing can affect performance in a visual search task. For example, search performance improves if a visual target and an auditory cue originate from the same spatial location, and it deteriorates if they originate from different locations. Moreover, it has recently been postulated that multisensory settings, i.e., experimental settings, in which critical stimuli are concurrent...<br/><br/>Rebecca E Paladini, Lorenzo Diana, Giuseppe A Zito, Thomas Nyffeler, Patric Wyss, Urs P Mosimann, René M Müri, Tobias Nef, Dario Cazzoli (2018) <i>PloS one</i> <i></i> <i></i> 13: 1 <br/>

//publicationslist.org/tobias.nef/refid463 2019-09-27T05:58:22Z

After severe injury or neurodegenerative disorders patients often experience long-term functional deficits, resulting in a reduction o performance in activities of daily living (ADL). Given their direct relevance to everyday functioning and quality of life, neurorehabilitative programs using simulated ADL's have seen increased interest recently. One of the core elements in simulated ADL's is the i...<br/><br/>Stephan M Gerber, Rene M Muri, Urs P Mosimann, Tobias Nef, Prabitha Urwyler (2018) <i>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</i> <i></i> <i></i> 2018: 1-4<br/>

//publicationslist.org/tobias.nef/refid491 2020-05-29T07:40:23Z

Martin Hatzinger, Ulrich Hemmeter, Therese Hirsbrunner, Edith Holsboer-Trachsler, Thomas Leyhe, Jean-Frédéric Mall, Urs Mosimann, Nicole Rach, Nathalie Trächsel, Egemen Savaskan (2018) <i>Praxis</i> <i></i> <i></i> 107: 3 127-144<br/>

//publicationslist.org/tobias.nef/refid478 2019-06-26T13:42:00Z

Word retrieval in bilingual speakers partly depends on executive control systems in the left prefrontal cortex - including dorsolateral prefrontal cortex (DLPFC). We tested the hypothesis that DLPFC modulates word production of words specifically in a second language (L2) by measuring the effects of anodal transcranial direct current stimulation (anodal-tDCS) over the DLPFC on picture naming and w...<br/><br/>Narges Radman, Juliane Britz, Karin Buetler, Brendan S Weekes, Lucas Spierer, Jean-Marie Annoni (2018) <i>Frontiers in neuroscience</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid430 2018-06-25T13:21:55Z

Prediction of peak work rate (WRpeak) for incremental exercise testing (IET) is important to bring subjects to their maximal performance within the recommended 8-12 min. This study developed a novel method for prediction of WRpeak for IET on cycles and treadmills.<br/><br/>Jittima Saengsuwan, Tobias Nef, Kenneth J Hunt (2017) <i>Clinical physiology and functional imaging</i> <i></i> <i></i> 37: 6 610-614<br/>

//publicationslist.org/tobias.nef/refid434 2017-11-24T07:16:30Z

Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments.<br/><br/>Mirjam R Heldner, Sigal Kaufmann-Ezra, Klemens Gutbrod, Corrado Bernasconi, Sandra Bigi, Verena Blatter, Heinrich P Mattle, René M Müri, Rajeev K Verma, Christian P Kamm (2017) <i>Frontiers in neurology</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid435 2017-11-24T07:16:30Z

Robert Gürkov, Luis Wittwer, Guillaume Speierer, René Müri, Georgios Mantokoudis, Roger Kalla (2017) <i>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</i> <i></i> <i></i> 128: 10 2048-2049<br/>

//publicationslist.org/tobias.nef/refid431 2017-11-24T07:15:10Z

After prolonged stay in an intensive care unit (ICU) patients often complain about cognitive impairments that affect health-related quality of life after discharge. The aim of this proof-of-concept study was to test the feasibility and effects of controlled visual and acoustic stimulation in a virtual reality (VR) setup in the ICU. The VR setup consisted of a head-mounted display in combination wi...<br/><br/>Stephan M Gerber, Marie-Madlen Jeitziner, Patric Wyss, Alvin Chesham, Prabitha Urwyler, René M Müri, Stephan M Jakob, Tobias Nef (2017) <i>Scientific reports</i> <i></i> <i></i> 7: 1 <br/>

//publicationslist.org/tobias.nef/refid422 2017-09-26T12:27:20Z

Despite growing interest in developing ecological assessment of difficulties in patients with Alzheimer's disease new methods assessing the cognitive difficulties related to functional activities are missing. To complete current evaluation, the use of Serious Games can be a promising approach as it offers the possibility to recreate a virtual environment with daily living activities and a precise ...<br/><br/>Vanessa Vallejo, Patric Wyss, Luca Rampa, Andrei V Mitache, René M Müri, Urs P Mosimann, Tobias Nef (2017) <i>PloS one</i> <i></i> <i></i> 12: 5 <br/>

//publicationslist.org/tobias.nef/refid436 2019-06-26T13:35:17Z

Neurostimulation of the dorsolateral prefrontal cortex (DLPFC) can modulate performance in cognitive tasks. In a recent study, however, transcranial direct current stimulation (tDCS) of the DLPFC did not affect implicit task sequence learning and consolidation in a paradigm that involved bimanual responses. Because bimanual performance increases the coupling between homologous cortical areas of th...<br/><br/>Branislav Savic, Dario Cazzoli, René Müri, Beat Meier (2017) <i>Scientific reports</i> <i></i> <i></i> 7: 1 <br/>

//publicationslist.org/tobias.nef/refid421 2017-02-28T13:53:25Z

Transcranial direct current stimulation (tDCS) is assumed to affect cortical excitability and dependent on the specific stimulation conditions either to increase or decrease learning.<br/><br/>Branislav Savic, René Müri, Beat Meier (2017) <i>Brain stimulation</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid418 2018-04-24T12:58:04Z

With a reduced level of alertness, healthy individuals typically show a rightward shift when deploying visual attention in space. The impact of alertness on the neural networks governing visuospatial attention is, however, poorly understood. By using a transcranial magnetic stimulation twin-coil approach, the present study aimed at investigating the effects of an alertness manipulation on the exci...<br/><br/>Rebecca E Paladini, René M Müri, Jurka Meichtry, Tobias Nef, Fred W Mast, Urs P Mosimann, Thomas Nyffeler, Dario Cazzoli (2017) <i>Cerebral cortex (New York, N.Y. : 1991)</i> <i></i> <i></i> 27: 1 233-243<br/>

//publicationslist.org/tobias.nef/refid417 2018-11-14T13:02:19Z

Cognitive impairment due to dementia decreases functionality in Activities of Daily Living (ADL). Its assessment is useful to identify care needs, risks and monitor disease progression. This study investigates differences in ADL pattern-performance between dementia patients and healthy controls using unobtrusive sensors. Around 9,600 person-hours of activity data were collected from the home of te...<br/><br/>Prabitha Urwyler, Reto Stucki, Luca Rampa, René Müri, Urs P Mosimann, Tobias Nef (2017) <i>Scientific reports</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid423 2017-05-17T06:58:16Z

In recent computerized cognitive training studies, video games have emerged as a promising tool that can benefit cognitive function and well-being. Whereas most video game training studies have used first-person shooter (FPS) action video games, subsequent studies found that older adults dislike this type of game and generally prefer casual video games (CVGs), which are a subtype of video games th...<br/><br/>Alvin Chesham, Patric Wyss, René Martin Müri, Urs Peter Mosimann, Tobias Nef (2017) <i>JMIR serious games</i> <i></i> <i></i> 5: 2 <br/>

//publicationslist.org/tobias.nef/refid424 2017-05-17T07:00:57Z

Goodale and Milner's two visual system hypothesis is an influential model for the understanding of the primate visual system. Lesions of either the ventral (occipito-temporal) or the dorsal (occipito-parietal) stream produce distinct and dissociated syndromes in humans: visual agnosia is typical for ventral damage, whereas optic ataxia (OA) for dorsal damage. We studied the case of a 59-year-old l...<br/><br/>Jurka R Meichtry, Dario Cazzoli, Silvia Chaves, Sebastian von Arx, Tobias Pflugshaupt, Roger Kalla, Claudio L Bassetti, Klemens Gutbrod, René M Müri (2017) <i>Journal of neuropsychology</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid428 2017-07-12T06:55:24Z

Schizophrenia is characterized by social interaction deficits contributing to poor functional outcome. Hand gesture use is particularly impaired, linked to frontal lobe dysfunction and frontal grey matter deficits. The functional neural correlates of impaired gesturing are currently unclear. We therefore investigated aberrant brain activity during impaired gesturing in schizophrenia. We included 2...<br/><br/>Katharina Stegmayer, Stephan Bohlhalter, Tim Vanbellingen, Andrea Federspiel, Roland Wiest, René M Müri, Werner Strik, Sebastian Walther (2017) <i>Schizophrenia bulletin</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid427 2017-07-12T06:55:24Z

Recent research provides evidence that galvanic vestibular stimulation (GVS) has a modulating effect on somatosensory perception and spatial cognition. However, other vestibular stimulation techniques have induced changes in affective control and decision making. The aim of this study was to investigate the effect of GVS on framing susceptibility in a risky-choice game. The participants were to de...<br/><br/>Nora Preuss, Roger Kalla, Rene Müri, Fred W Mast (2017) <i>Scientific reports</i> <i></i> <i></i> 7: 1 <br/>

//publicationslist.org/tobias.nef/refid426 2018-04-24T12:57:31Z

Patients with Parkinson's disease exhibit disturbed manual dexterity. This impairment leads to difficulties in activities of daily living, such as buttoning a shirt or hand-writing. The aim of the present study was to investigate the effectiveness of a home-based dexterity program on fine motor skills in a single-blinded, randomized controlled trial, in patients with Parkinson's disease.<br/><br/>Tim Vanbellingen, Thomas Nyffeler, Julia Nigg, Jorina Janssens, Johanna Hoppe, Tobias Nef, René M Müri, Erwin E H van Wegen, Gert Kwakkel, Stephan Bohlhalter (2017) <i>Parkinsonism & related disorders</i> <i></i> <i></i> 41: 92-98<br/>

//publicationslist.org/tobias.nef/refid425 2018-06-25T13:21:55Z

Motor tests performed at stroke onset have been shown to predict the recovery of upper limb motor impairment. Less is known about upper limb recovery at the level of functional activity or of participation and how spatial neglect may influence the integration of the upper limb in the activities of daily living (ADL). Our objective was to investigate whether the initial severity of spatial neglect ...<br/><br/>Tim Vanbellingen, Beatrice Ottiger, Noortje Maaijwee, Tobias Pflugshaupt, Stephan Bohlhalter, René M Müri, Tobias Nef, Dario Cazzoli, Thomas Nyffeler (2017) <i>Cerebrovascular diseases (Basel, Switzerland)</i> <i></i> <i></i> 44: 3-4 122-127<br/>

//publicationslist.org/tobias.nef/refid429 2017-09-26T12:27:20Z

In stroke patients, the clinical presentation of visual field defects (VFDs) is frequently accompanied by visual neglect, i.e., the inability to attend and respond to the contralesional space. However, the diagnostic discrimination between the lack of reactions to contralesional stimuli due to VFDs or visual neglect is challenging during clinical examination. This discrimination is particularly re...<br/><br/>Thomas Nyffeler, Rebecca E Paladini, Simone Hopfner, Oliver Job, Tobias Nef, Tobias Pflugshaupt, Tim Vanbellingen, Stephan Bohlhalter, René M Müri, Georg Kerkhoff, Dario Cazzoli (2017) <i>Frontiers in neurology</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid433 2018-04-24T12:59:52Z

Traumatic brain injuries are common, especially within the elderly population, which is typically defined as age 65 and older. This narrative review aims at summarizing and critically evaluating important aspects of their health care management in covering the entire pathway from prehospital care to rehabilitation and beyond.<br/><br/>Rahel Schumacher, René M Müri, Bernhard Walder (2017) <i>Current neurology and neuroscience reports</i> <i></i> <i></i> 17: 12 <br/>

//publicationslist.org/tobias.nef/refid439 2018-11-14T13:03:28Z

This review provides an update on interdisciplinary treatment for dizziness. Dizziness can have various causes and the treatment offered should depend on the cause. After reading this article, the clinician will have an overview of current treatment recommendations. Recommendations are made for the most prevalent causes of dizziness including acute and chronic vestibular syndromes, vestibular neur...<br/><br/>Rainer Spiegel, Heiko Rust, Thomas Baumann, Hergen Friedrich, Raoul Sutter, Martina Göldlin, Christiane Rosin, René Müri, Georgios Mantokoudis, Roland Bingisser, Michael Strupp, Roger Kalla (2017) <i>Swiss medical weekly</i> <i></i> <i></i> 147: <br/>

//publicationslist.org/tobias.nef/refid454 2018-09-13T12:28:22Z

Previous research suggests that the effectiveness of robotic training depends on the motor task to be learned. However, it is still an open question which specific task's characteristics influence the efficacy of error-modulating training strategies. Motor tasks can be classified based on the time characteristics of the task, in particular the task's duration (discrete vs. continuous). Continuous ...<br/><br/>Laura Marchal-Crespo, Nicole Rappo, Robert Riener (2017) <i>Experimental brain research</i> <i></i> <i></i> 235: 12 3799-3816<br/>

//publicationslist.org/tobias.nef/refid492 2020-05-29T07:40:23Z

The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness o...<br/><br/>Giovanni B Frisoni, Marina Boccardi, Frederik Barkhof, Kaj Blennow, Stefano Cappa, Konstantinos Chiotis, Jean-Francois Démonet, Valentina Garibotto, Panteleimon Giannakopoulos, Anton Gietl, Oskar Hansson, Karl Herholz, Clifford R Jack, Flavio Nobili, Agneta Nordberg, Heather M Snyder, Mara Ten Kate, Andrea Varrone, Emiliano Albanese, Stefanie Becker, Patrick Bossuyt, Maria C Carrillo, Chiara Cerami, Bruno Dubois, Valentina Gallo, Ezio Giacobini, Gabriel Gold, Samia Hurst, Anders Lönneborg, Karl-Olof Lovblad, Niklas Mattsson, José-Luis Molinuevo, Andreas U Monsch, Urs Mosimann, Alessandro Padovani, Agnese Picco, Corinna Porteri, Osman Ratib, Laure Saint-Aubert, Charles Scerri, Philip Scheltens, Jonathan M Schott, Ida Sonni, Stefan Teipel, Paolo Vineis, Pieter Jelle Visser, Yutaka Yasui, Bengt Winblad (2017) <i>The Lancet. Neurology</i> <i></i> <i></i> 16: 8 661-676<br/>

//publicationslist.org/tobias.nef/refid443 2018-11-14T13:05:26Z

The aim of this study was to assess the feasibility, acceptability and effectiveness of a pilot COPD integrated care programme implemented in Valais, Switzerland.<br/><br/>Tania Carron, Pierre-Olivier Bridevaux, Karin Lörvall, Rachel Parmentier, Jean-Bernard Moix, Vincent Beytrison, Raymond Pernet, Constance Rey, Pierre-Yves Roberfroid, Prashant N Chhajed, Thomas Dieterle, Ladina Joos Zellweger, Malcolm Kohler, Sabrina Maier, David Miedinger, Robert Thurnheer, Pascal Urwyler, Jean-Marie Tschopp, Emilie Zuercher, Jörg Daniel Leuppi, Bernard Burnand, Isabelle Peytremann-Bridevaux (2017) <i>Swiss medical weekly</i> <i></i> <i></i> 147: <br/>

//publicationslist.org/tobias.nef/refid453 2018-09-13T12:28:22Z

Up to date, the functional gains obtained after robot-aided gait rehabilitation training are limited. Error augmenting strategies have a great potential to enhance motor learning of simple motor tasks. However, little is known about the effect of these error modulating strategies on complex tasks, such as relearning to walk after a neurologic accident. Additionally, neuroimaging evaluation of brai...<br/><br/>Laura Marchal-Crespo, Lars Michels, Lukas Jaeger, Jorge López-Olóriz, Robert Riener (2017) <i>Frontiers in neuroscience</i> <i></i> <i></i> 11: <br/>

//publicationslist.org/tobias.nef/refid440 2018-11-14T13:03:28Z

This review aims to assist emergency physicians in finding the underlying aetiology when a patient presents with dizziness to the emergency department. After reading this review, the emergency physician will be able to consider the most relevant differential diagnoses and have an idea about dangerous aetiologies that require immediate action. The emergency physician will also know what diagnostic ...<br/><br/>Rainer Spiegel, Mark Kirsch, Christiane Rosin, Heiko Rust, Thomas Baumann, Raoul Sutter, Hergen Friedrich, Martina Göldlin, René Müri, Roger Kalla, Roland Bingisser, Georgios Mantokoudis (2017) <i>Swiss medical weekly</i> <i></i> <i></i> 147: <br/>

//publicationslist.org/tobias.nef/refid442 2018-01-03T15:14:12Z

Considerable evidence suggests that, on a group level, human visuospatial attention is asymmetrically organized, with a right-hemispheric dominance. The asymmetrical organization of the superior longitudinal fasciculus (SLF) has been shown to account for the right-hemispheric dominance in visual attention. However, such account is by no means universal, and large individual differences in asymmetr...<br/><br/>Dario Cazzoli, Magdalena Chechlacz (2017) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 86: 230-246<br/>

//publicationslist.org/tobias.nef/refid407 2016-06-02T13:23:38Z

Reading strategies vary across languages according to orthographic depth - the complexity of the grapheme in relation to phoneme conversion rules - notably at the level of eye movement patterns. We recently demonstrated that a group of early bilinguals, who learned both languages equally under the age of seven, presented a first fixation location (FFL) closer to the beginning of words when reading...<br/><br/>Diego de León Rodríguez, Karin A Buetler, Noëmi Eggenberger, Marina Laganaro, Thomas Nyffeler, Jean-Marie Annoni, René M Müri (2016) <i>Frontiers in psychology</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid406 2017-02-28T14:00:22Z

Gesturing plays an important role in social behavior and social learning. Deficits are frequent in schizophrenia and may contribute to impaired social functioning. Information about deficits during the course of the disease and presence of severity and patterns of impairment in first-episode patients is missing. Hence, we aimed to investigate gesturing in first- compared to multiple-episode schizo...<br/><br/>Katharina Stegmayer, Jeanne Moor, Tim Vanbellingen, Stephan Bohlhalter, René M Müri, Werner Strik, Sebastian Walther (2016) <i>Neuropsychobiology</i> <i></i> <i></i> 73: 4 201-208<br/>

//publicationslist.org/tobias.nef/refid405 2016-06-02T13:23:38Z

The human turn-taking system regulates the smooth and precise exchange of speaking turns during face-to-face interaction. Recent studies investigated the processing of ongoing turns during conversation by measuring the eye movements of noninvolved observers. The findings suggest that humans shift their gaze in anticipation to the next speaker before the start of the next turn. Moreover, there is e...<br/><br/>Basil C Preisig, Noëmi Eggenberger, Giuseppe Zito, Tim Vanbellingen, Rahel Schumacher, Simone Hopfner, Klemens Gutbrod, Thomas Nyffeler, Dario Cazzoli, Jean-Marie Annoni, Stephan Bohlhalter, René M Müri (2016) <i>Journal of cognitive neuroscience</i> <i></i> <i></i> : 1-12<br/>

//publicationslist.org/tobias.nef/refid408 2017-02-28T14:00:22Z

Screening of aphasia in acute stroke is crucial for directing patients to early language therapy. The Language Screening Test (LAST), originally developed in French, is a validated language screening test that allows detection of a language deficit within a few minutes. The aim of the present study was to develop and validate two parallel German versions of the LAST.<br/><br/>M Koenig-Bruhin, T Vanbellingen, R Schumacher, T Pflugshaupt, J M Annoni, R M Müri, S Bohlhalter, T Nyffeler (2016) <i>Cerebrovascular diseases extra</i> <i></i> <i></i> 6: 1 27-31<br/>

//publicationslist.org/tobias.nef/refid404 2016-05-09T06:15:06Z

One of the leading approaches to non-invasively treat a variety of brain disorders is transcranial magnetic stimulation (TMS). However, despite its clinical prevalence, very little is known about the action of TMS at the cellular level let alone what effect it might have at the subcellular level (e.g. dendrites). Here, we examine the effect of single-pulse TMS on dendritic activity in layer 5 pyra...<br/><br/>Sean C Murphy, Lucy M Palmer, Thomas Nyffeler, René M Müri, Matthew E Larkum (2016) <i>eLife</i> <i></i> <i></i> 5: <br/>

//publicationslist.org/tobias.nef/refid411 2016-09-16T10:25:19Z

Visual exploration is an omnipresent activity in everyday life, and might represent an important determinant of visual attention deficits in patients with Alzheimer's Disease (AD). The present study aimed at investigating visual search performance in AD patients, in particular target detection in the far periphery, in daily living scenes. Eighteen AD patients and 20 healthy controls participated i...<br/><br/>Vanessa Vallejo, Dario Cazzoli, Luca Rampa, Giuseppe A Zito, Flurin Feuerstein, Nicole Gruber, René M Müri, Urs P Mosimann, Tobias Nef (2016) <i>Frontiers in aging neuroscience</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid409 2016-09-16T10:25:19Z

Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson's disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with o...<br/><br/>Tim Vanbellingen, Manuela Wapp, Katharina Stegmayer, Manuel Bertschi, Eugenio Abela, Stefanie Kübel, Thomas Nyffeler, René Müri, Sebastian Walther, Tobias Nef, Mark Hallett, Stephan Bohlhalter (2016) <i>Journal of neural transmission (Vienna, Austria : 1996)</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid401 2016-03-15T10:53:15Z

Robert Gürkov, Guillaume Speierer, Luis Wittwer, René Muri, Roger Kalla (2016) <i>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</i> <i></i> <i></i> 127: 4 2115-2118<br/>

//publicationslist.org/tobias.nef/refid398 2017-05-17T06:59:04Z

Increasing time-on-task leads to fatigue and, as shown by previous research, differentially affects the deployment of visual attention towards the left and the right visual space. In healthy participants, an increasing rightward bias is commonly observed with increasing time-on-task. Yet, it is unclear whether specific mechanisms involved in the spatial deployment of visual attention are different...<br/><br/>Rebecca E Paladini, Lorenzo Diana, Thomas Nyffeler, Urs P Mosimann, Tobias Nef, René M Müri, Dario Cazzoli (2016) <i>Neuropsychologia</i> <i></i> <i></i> 92: 107-114<br/>

//publicationslist.org/tobias.nef/refid397 2016-01-18T15:38:09Z

Co-speech gestures are omnipresent and a crucial element of human interaction by facilitating language comprehension. However, it is unclear whether gestures also support language comprehension in aphasic patients. Using visual exploration behavior analysis, the present study aimed to investigate the influence of congruence between speech and co-speech gestures on comprehension in terms of accurac...<br/><br/>Noëmi Eggenberger, Basil C Preisig, Rahel Schumacher, Simone Hopfner, Tim Vanbellingen, Thomas Nyffeler, Klemens Gutbrod, Jean-Marie Annoni, Stephan Bohlhalter, Dario Cazzoli, René M Müri (2016) <i>PloS one</i> <i></i> <i></i> 11: 1 <br/>

//publicationslist.org/tobias.nef/refid396 2016-01-18T15:38:09Z

Tim Vanbellingen, Romina Simonet, Stefanie Kübel, Christina Knisoviti, Thomas Nyffeler, René M Müri, Stephan Bohlhalter (2016) <i>International journal of stroke : official journal of the International Stroke Society</i> <i></i> <i></i> 11: 1 NP11-NP12<br/>

//publicationslist.org/tobias.nef/refid399 2018-04-24T12:58:04Z

Visual hallucinations (VH) most commonly occur in eye disease (ED), Parkinson disease (PD), and Lewy body dementia (LBD). The phenomenology of VH is likely to carry important information about the brain areas within the visual system generating them.<br/><br/>Prabitha Urwyler, Tobias Nef, René Müri, Neil Archibald, Selina Margaret Makin, Daniel Collerton, John-Paul Taylor, David Burn, Ian McKeith, Urs Peter Mosimann (2016) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 24: 5 350-358<br/>

//publicationslist.org/tobias.nef/refid400 2016-03-15T10:53:15Z

A large body of research demonstrated that participants preferably look back to the encoding location when retrieving visual information from memory. However, the role of this 'looking back to nothing' is still debated. The goal of the present study was to extend this line of research by examining whether an important area in the cortical representation of the oculomotor system, the frontal eye fi...<br/><br/>Andrea L Wantz, Corinna S Martarelli, Dario Cazzoli, Roger Kalla, René Müri, Fred W Mast (2016) <i>Neuroreport</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid402 2016-05-09T06:18:43Z

An impairment of the spatial deployment of visual attention during exploration of static (i.e., motionless) stimuli is a common finding after an acute, right-hemispheric stroke. However, less is known about how these deficits: (a) are modulated through naturalistic motion (i.e., without directional, specific spatial features); and, (b) evolve in the subacute/chronic post-stroke phase. In the prese...<br/><br/>Dario Cazzoli, Simone Hopfner, Basil Preisig, Giuseppe Zito, Tim Vanbellingen, Michael Jäger, Tobias Nef, Urs Mosimann, Stephan Bohlhalter, René M Müri, Thomas Nyffeler (2016) <i>Neuropsychologia</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid412 2016-09-16T10:25:19Z

Perceptual accuracy is known to be influenced by stimuli location within the visual field. In particular, it seems to be enhanced in the lower visual hemifield (VH) for motion and space processing, and in the upper VH for object and face processing. The origins of such asymmetries are attributed to attentional biases across the visual field, and in the functional organization of the visual system....<br/><br/>Giuseppe A Zito, Dario Cazzoli, René M Müri, Urs P Mosimann, Tobias Nef (2016) <i>Frontiers in behavioral neuroscience</i> <i></i> <i></i> 10: <br/>

//publicationslist.org/tobias.nef/refid403 2016-05-09T06:15:06Z

The neural correlates of impaired performance of gestures are currently unclear. Lesion studies showed variable involvement of the ventro-dorsal stream particularly left inferior frontal gyrus (IFG) in gesture performance on command. However, findings cannot be easily generalized as lesions may be biased by the architecture of vascular supply and involve brain areas beyond the critical region. The...<br/><br/>Katharina Stegmayer, Stephan Bohlhalter, Tim Vanbellingen, Andrea Federspiel, Jeanne Moor, Roland Wiest, René Müri, Werner Strik, Sebastian Walther (2016) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 78: 125-137<br/>

//publicationslist.org/tobias.nef/refid410 2017-02-28T13:51:39Z

Exercise testing devices for evaluating cardiopulmonary fitness in patients with severe disability after stroke are lacking, but we have adapted a robotics-assisted tilt table (RATT) for cardiopulmonary exercise testing (CPET). Using the RATT in a sample of patients after stroke, this study aimed to investigate test-retest reliability and repeatability of CPET and to prospectively investigate chan...<br/><br/>Jittima Saengsuwan, Lucia Berger, Corina Schuster-Amft, Tobias Nef, Kenneth J Hunt (2016) <i>BMC neurology</i> <i></i> <i></i> 16: 1 <br/>

//publicationslist.org/tobias.nef/refid420 2017-02-28T13:51:39Z

Patients with Parkinson's disease exhibit disturbed dexterity. Validated self-reported outcomes for dexterity in Parkinson's disease are lacking. The aim of this study was to investigate the reliability, content and construct validity of a new Dexterity Questionnaire 24.<br/><br/>Tim Vanbellingen, Thomas Nyffeler, Tobias Nef, Gert Kwakkel, Stephan Bohlhalter, Erwin E H van Wegen (2016) <i>Parkinsonism & related disorders</i> <i></i> <i></i> 33: 78-83<br/>

//publicationslist.org/tobias.nef/refid457 2018-09-13T12:28:22Z

To date, the neurophysiological correlates of muscle activation required for weight bearing during walking are poorly understood although, a supraspinal involvement has been discussed in the literature for many years. The present study investigates the effect of simulated ground reaction forces (0, 20, and 40% of individual body weight) on brain activation in sixteen healthy participants. A magnet...<br/><br/>Lukas Jaeger, Laura Marchal-Crespo, Peter Wolf, Andreas R Luft, Robert Riener, Lars Michels, Spyros Kollias (2016) <i>Brain topography</i> <i></i> <i></i> 29: 1 193-205<br/>

//publicationslist.org/tobias.nef/refid413 2017-07-12T06:54:16Z

Dementia with Lewy bodies (DLB) patients frequently experience well formed recurrent complex visual hallucinations (RCVH). This is associated with reduced blood flow or hypometabolism on imaging of the primary visual cortex. To understand these associations in DLB we used pathological and biochemical analysis of the primary visual cortex to identify changes that could underpin RCVH. Alpha-synuclei...<br/><br/>Ahmad A Khundakar, Peter S Hanson, Daniel Erskine, Nichola Z Lax, Joseph Roscamp, Evangelia Karyka, Eliona Tsefou, Preeti Singh, Simon J Cockell, Andrew Gribben, Lynne Ramsay, Peter G Blain, Urs P Mosimann, Deborah J Lett, Matthias Elstner, Douglass M Turnbull, Charles C Xiang, Michael J Brownstein, John T O'Brien, John-Paul Taylor, Johannes Attems, Alan J Thomas, Ian G McKeith, Christopher M Morris (2016) <i>Acta neuropathologica communications</i> <i></i> <i></i> 4: 1 <br/>

//publicationslist.org/tobias.nef/refid441 2018-01-03T15:14:12Z

Magdalena Chechlacz, Glyn W Humphreys, Dario Cazzoli (2016) <i>Neuropsychologia</i> <i></i> <i></i> 92: 1-6<br/>

//publicationslist.org/tobias.nef/refid419 2017-02-28T13:51:39Z

Good responsive functional outcome measures are important to measure change in stroke patients. The aim of study was to compare the internal and external responsiveness, floor and ceiling effects of the motor, cognition, and communication subscales of the Lucerne ICF-based Multidisciplinary Observation Scale (LIMOS) with the motor and cognition subscales of the Functional Independence Measure (FIM...<br/><br/>Tim Vanbellingen, Beatrice Ottiger, Tobias Pflugshaupt, Jan Mehrholz, Stephan Bohlhalter, Tobias Nef, Thomas Nyffeler (2016) <i>Frontiers in neurology</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid455 2018-09-13T12:28:22Z

Previous results suggest that haptic guidance enhances learning of the timing components of motor tasks, whereas error amplification is better for learning the spatial components. In this paper we evaluate a novel mixed guidance controller that combines haptic guidance and error amplification to simultaneously promote learning of the timing and spatial components. The controller is realized using ...<br/><br/>Laura Marchal-Crespo, Tanja Baumann, Daniela Fichmann, Steve Maassen, Jaime E Duarte, Robert Riener (2016) <i>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</i> <i></i> <i></i> 2016: 5136-5139<br/>

//publicationslist.org/tobias.nef/refid414 2016-09-16T10:27:32Z

The functional outcome of schizophrenia is heterogeneous and markers of the course are missing. Functional outcome is associated with social cognition and negative symptoms. Gesture performance and nonverbal social perception are critically impaired in schizophrenia. Here, we tested whether gesture performance or nonverbal social perception could predict functional outcome and the ability to adequ...<br/><br/>Sebastian Walther, Sarah Eisenhardt, Stephan Bohlhalter, Tim Vanbellingen, René Müri, Werner Strik, Katharina Stegmayer (2016) <i>Schizophrenia bulletin</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid415 2016-09-16T10:27:32Z

To describe the discharge destination of patients with severe traumatic brain injury (sTBI) after acute care. To identify predictors associated with inpatient rehabilitation (vs discharge home) and to identify predictors associated with neurorehabilitation (vs general rehabilitation).<br/><br/>Rahel Schumacher, Bernhard Walder, Cécile Delhumeau, René M Müri (2016) <i>Brain injury</i> <i></i> <i></i> 30: 10 1186-1193<br/>

//publicationslist.org/tobias.nef/refid416 2016-09-16T10:27:32Z

Hemianopic reading impairment is a consequence of a visual field defect to either the right or the left side and is characterized by an increased reading time and reduced reading performance. Depending on the side of the visual field defect, reading will be affected differently: Patients suffering from a visual field defect to the right side have noticeable difficulties in reading fluently with sl...<br/><br/>Denise de Jong, Sigal Kaufmann-Ezra, Jurka R Meichtry, Sebastian von Arx, Dario Cazzoli, Klemens Gutbrod, René M Müri (2016) <i>Journal of clinical and experimental neuropsychology</i> <i></i> <i></i> : 1-7<br/>

//publicationslist.org/tobias.nef/refid383 2015-10-21T13:14:17Z

We evaluated the feasibility of an augmented robotics-assisted tilt table (RATT) for incremental cardiopulmonary exercise testing (CPET) and exercise training in dependent-ambulatory stroke patients.<br/><br/>Jittima Saengsuwan, Celine Huber, Jonathan Schreiber, Corina Schuster-Amft, Tobias Nef, Kenneth J Hunt (2015) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 12: 1 <br/>

//publicationslist.org/tobias.nef/refid377 2015-04-27T06:26:38Z

Schizophrenia patients are severely impaired in nonverbal communication, including social perception and gesture production. However, the impact of nonverbal social perception on gestural behavior remains unknown, as is the contribution of negative symptoms, working memory, and abnormal motor behavior. Thus, the study tested whether poor nonverbal social perception was related to impaired gesture ...<br/><br/>Sebastian Walther, Katharina Stegmayer, Jeanne Sulzbacher, Tim Vanbellingen, René Müri, Werner Strik, Stephan Bohlhalter (2015) <i>Schizophrenia bulletin</i> <i></i> <i></i> 41: 2 338-345<br/>

//publicationslist.org/tobias.nef/refid376 2015-04-27T06:26:38Z

According to the direct matching hypothesis, perceived movements automatically activate existing motor components through matching of the perceived gesture and its execution. The aim of the present study was to test the direct matching hypothesis by assessing whether visual exploration behavior correlate with deficits in gestural imitation in left hemisphere damaged (LHD) patients. Eighteen LHD pa...<br/><br/>Tim Vanbellingen, Rahel Schumacher, Noëmi Eggenberger, Simone Hopfner, Dario Cazzoli, Basil C Preisig, Manuel Bertschi, Thomas Nyffeler, Klemens Gutbrod, Claudio L Bassetti, Stephan Bohlhalter, René M Müri (2015) <i>Neuropsychologia</i> <i></i> <i></i> 71: 158-164<br/>

//publicationslist.org/tobias.nef/refid378 2016-03-15T10:50:40Z

Activities of daily living (ADL) are important for quality of life. They are indicators of cognitive health status and their assessment is a measure of independence in everyday living. ADL are difficult to reliably assess using questionnaires due to self-reporting biases. Various sensor-based (wearable, in-home, intrusive) systems have been proposed to successfully recognize and quantify ADL witho...<br/><br/>Prabitha Urwyler, Luca Rampa, Reto Stucki, Marcel Büchler, René Müri, Urs P Mosimann, Tobias Nef (2015) <i>Biomedical engineering online</i> <i></i> <i></i> 14: <br/>

//publicationslist.org/tobias.nef/refid382 2015-10-21T13:14:17Z

Brain lesions in the visual associative cortex are known to impair visual perception, i.e., the capacity to correctly perceive different aspects of the visual world, such as motion, color, or shapes. Visual perception can be influenced by non-invasive brain stimulation such as transcranial direct current stimulation (tDCS). In a recently developed technique called high definition (HD) tDCS, small ...<br/><br/>Giuseppe A Zito, Theresa Senti, Dario Cazzoli, René M Müri, Urs P Mosimann, Thomas Nyffeler, Tobias Nef (2015) <i>Frontiers in behavioral neuroscience</i> <i></i> <i></i> 9: <br/>

//publicationslist.org/tobias.nef/refid359 2015-04-28T11:55:00Z

When briefly presented with pairs of words, skilled readers can sometimes report words with migrated letters (e.g., they report hunt when presented with the words hint and hurt). This and other letter migration phenomena have been often used to investigate factors that influence reading such as letter position coding. However, the neural basis of letter migration is poorly understood. Previous evi...<br/><br/>Dario Cazzoli, René M Müri, Christopher Kennard, Clive R Rosenthal (2015) <i>Journal of cognitive neuroscience</i> <i></i> <i></i> 27: 2 377-386<br/>

//publicationslist.org/tobias.nef/refid375 2015-04-27T06:26:10Z

Robotics-assisted tilt table (RATT) technology provides body support, cyclical stepping movement and physiological loading. This technology can potentially be used to facilitate the estimation of peak cardiopulmonary performance parameters in patients who have neurological or other problems that may preclude testing on a treadmill or cycle ergometer. The aim of the study was to compare the magnitu...<br/><br/>Jittima Saengsuwan, Tobias Nef, Marco Laubacher, Kenneth J Hunt (2015) <i>PloS one</i> <i></i> <i></i> 10: 4 <br/>

//publicationslist.org/tobias.nef/refid379 2015-12-16T14:56:51Z

Smart homes for the aging population have recently started attracting the attention of the research community. The "health state" of smart homes is comprised of many different levels; starting with the physical health of citizens, it also includes longer-term health norms and outcomes, as well as the arena of positive behavior changes. One of the problems of interest is to monitor the activities o...<br/><br/>Tobias Nef, Prabitha Urwyler, Marcel Büchler, Ioannis Tarnanas, Reto Stucki, Dario Cazzoli, René Müri, Urs Mosimann (2015) <i>Sensors (Basel, Switzerland)</i> <i></i> <i></i> 15: 5 11725-11740<br/>

//publicationslist.org/tobias.nef/refid381 2015-10-21T13:14:17Z

The decision when to cross a street safely is a challenging task that poses high demands on perception and cognition. Both can be affected by normal aging, neurodegenerative disorder, and brain injury, and there is an increasing interest in studying street-crossing decisions. In this article, we describe how driving simulators can be modified to study pedestrians' street-crossing decisions. The dr...<br/><br/>M Jäger, T Nyffeler, R Müri, U P Mosimann, T Nef (2015) <i>Assistive technology : the official journal of RESNA</i> <i></i> <i></i> 27: 1 1-8<br/>

//publicationslist.org/tobias.nef/refid373 2015-01-29T10:22:44Z

ABSTRACT Background: Driving a car requires adapting one's behavior to current task demands taking into account one's capacities. With increasing age, driving-relevant cognitive performance may decrease, creating a need for risk-reducing behavioral adaptations. Three different kinds of behavioral adaptations are known: selection, optimization, and compensation. These can occur on the tactical and ...<br/><br/>Rahel Bieri, Tobias Nef, René M Müri, Urs P Mosimann (2015) <i>International psychogeriatrics / IPA</i> <i></i> <i></i> : 1-11<br/>

//publicationslist.org/tobias.nef/refid368 2015-04-28T11:54:12Z

Co-speech gestures are part of nonverbal communication during conversations. They either support the verbal message or provide the interlocutor with additional information. Furthermore, they prompt as nonverbal cues the cooperative process of turn taking. In the present study, we investigated the influence of co-speech gestures on the perception of dyadic dialogue in aphasic patients. In particula...<br/><br/>Basil C Preisig, Noëmi Eggenberger, Giuseppe Zito, Tim Vanbellingen, Rahel Schumacher, Simone Hopfner, Thomas Nyffeler, Klemens Gutbrod, Jean-Marie Annoni, Stephan Bohlhalter, René M Müri (2015) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 64: 157-168<br/>

//publicationslist.org/tobias.nef/refid367 2015-04-27T06:26:10Z

Patients with amnestic mild cognitive impairment are at high risk for developing Alzheimer's disease. Besides episodic memory dysfunction they show deficits in accessing contextual knowledge that further specifies a general spatial navigation task or an executive function (EF) virtual action planning. Virtual reality (VR) environments have already been successfully used in cognitive rehabilitation...<br/><br/>Ioannis Tarnanas, Nikos Laskaris, Magda Tsolaki, René Muri, Tobias Nef, Urs P Mosimann (2015) <i>Advances in experimental medicine and biology</i> <i></i> <i></i> 821: 63-77<br/>

//publicationslist.org/tobias.nef/refid366 2015-12-16T15:01:52Z

Continuous theta burst stimulation (cTBS) represents a promising approach in the treatment of neglect syndrome. However, it is not known whether cTBS in conjunction with another technique may enhance the therapeutic effects. In the present sham-controlled study, we aimed to combine cTBS with smooth pursuit training (SPT), another method known to effectively improve neglect symptoms, and to evaluat...<br/><br/>Simone Hopfner, Dario Cazzoli, René M Müri, Tobias Nef, Urs P Mosimann, Stephan Bohlhalter, Tim Vanbellingen, Thomas Nyffeler (2015) <i>Neuropsychologia</i> <i></i> <i></i> 74: 145-151<br/>

//publicationslist.org/tobias.nef/refid370 2018-01-03T15:15:12Z

Visual hallucinations (VHs) are a very personal experience, and it is not clear whether information about them is best provided by informants or patients. Some patients may not share their hallucinatory experiences with caregivers to avoid distress or for fear of being labeled insane, and others do not have informants at all, which limits the use of informant-based questionnaires. The aim of this ...<br/><br/>Prabitha Urwyler, Tobias Nef, René M Müri, Alison Killen, Daniel Collerton, David Burn, Ian McKeith, Urs Peter Mosimann (2015) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 23: 9 970-976<br/>

//publicationslist.org/tobias.nef/refid371 2015-01-29T10:22:44Z

Impaired manual dexterity is frequent and disabling in patients with multiple sclerosis (MS), affecting activities of daily living (ADL) and quality of life.<br/><br/>Christian P Kamm, Heinrich P Mattle, René M Müri, Mirjam R Heldner, Verena Blatter, Sandrine Bartlome, Judith Lüthy, Debora Imboden, Giovanna Pedrazzini, Stephan Bohlhalter, Roger Hilfiker, Tim Vanbellingen (2015) <i>Multiple sclerosis (Houndmills, Basingstoke, England)</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid384 2015-10-21T13:14:17Z

In stroke patients, neglect diagnostic is often performed by means of paper-pencil cancellation tasks. These tasks entail static stimuli, and provide no information concerning possible changes in the severity of neglect symptoms when patients are confronted with motion. We therefore aimed to directly contrast the cancellation behaviour of neglect patients under static and dynamic conditions. Since...<br/><br/>Simone Hopfner, Sonja Kesselring, Dario Cazzoli, Klemens Gutbrod, Annett Laube-Rosenpflanzer, Magdalena Chechlacz, Tobias Nef, Urs Mosimann, Stephan Bohlhalter, René M Müri, Thomas Nyffeler (2015) <i>PloS one</i> <i></i> <i></i> 10: 7 <br/>

//publicationslist.org/tobias.nef/refid372 2015-01-29T10:22:44Z

The frontal eye field (FEF) is known to be involved in saccade generation and visual attention control. Studies applying covert attentional orienting paradigms have shown that the right FEF is involved in attentional shifts to both the left and the right hemifield. In the current study, we aimed at examining the effects of inhibitory continuous theta burst (cTBS) transcranial magnetic stimulation ...<br/><br/>Dario Cazzoli, Simon Jung, Thomas Nyffeler, Tobias Nef, Pascal Wurtz, Urs P Mosimann, René M Müri (2015) <i>Neuropsychologia</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid374 2018-01-03T15:15:12Z

Central and peripheral vision is needed for object detection. Previous research has shown that visual target detection is affected by age. In addition, light conditions also influence visual exploration. The aim of the study was to investigate the effects of age and different light conditions on visual exploration behavior and on driving performance during simulated driving.<br/><br/>Prabitha Urwyler, Nicole Gruber, René M Müri, Michael Jäger, Rahel Bieri, Thomas Nyffeler, Urs P Mosimann, Tobias Nef (2015) <i>BMC geriatrics</i> <i></i> <i></i> 15: <br/>

//publicationslist.org/tobias.nef/refid380 2016-03-15T10:50:40Z

BACKGROUND/STUDY CONTEXT: Older drivers are at increased risk of becoming involved in car crashes. Contrary to well-studied illness-related factors contributing to crash risk, the non-illness-related factors that can influence safety of older drivers are underresearched.<br/><br/>Tobias Nef, Rahel Bieri, René M Müri, Urs P Mosimann (2015) <i>Experimental aging research</i> <i></i> <i></i> 41: 3 325-360<br/>

//publicationslist.org/tobias.nef/refid394 2016-01-18T15:36:44Z

Computer games for a serious purpose - so called serious games can provide additional information for the screening and diagnosis of cognitive impairment. Moreover, they have the advantage of being an ecological tool by involving daily living tasks. However, there is a need for better comprehensive designs regarding the acceptance of this technology, as the target population is older adults that a...<br/><br/>Vanessa Vallejo, Andrei V Mitache, Ioannis Tarnanas, Rene Muri, Urs P Mosimann, Tobias Nef (2015) <i>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</i> <i></i> <i></i> 2015: 1327-1330<br/>

//publicationslist.org/tobias.nef/refid393 2016-09-16T10:25:19Z

Visual perception is not identical in the upper and lower visual hemifields. The mechanisms behind this difference can be found at the retinal, cortical, or higher attentional level. In this study, a new visual test battery, that involves real-time comparisons of complex visual stimuli, such as shape of objects, and speed of moving dot patterns, in the upper and lower visual hemifields, is present...<br/><br/>Giuseppe A Zito, Rene Muri, Urs P Mosimann, Thomas Nyffeler, Tobias Nef (2015) <i>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</i> <i></i> <i></i> 2015: 2522-2525<br/>

//publicationslist.org/tobias.nef/refid385 2015-10-21T13:16:05Z

The present topical review deals with the motor control of facial expressions in humans. Facial expressions are a central part of human communication. Emotional face expressions have a crucial role in human non-verbal behavior, allowing a rapid transfer of information between individuals. Facial expressions can be both voluntarily or emotionally controlled. Recent studies in non-human primates and...<br/><br/>René M Müri (2015) <i>The Journal of comparative neurology</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid456 2018-09-13T12:28:22Z

Brain activity has been shown to undergo cortical and sub-cortical functional reorganisation over the course of gait rehabilitation in patients suffering from a spinal cord injury or a stroke. These changes however, have not been completely elucidated by neuroimaging to date, mainly due to the scarcity of long-term, follow-up investigations. The magnetic resonance imaging (MRI) compatible stepper ...<br/><br/>Lukas Jaeger, Laura Marchal-Crespo, Peter Wolf, Robert Riener, Spyros Kollias, Lars Michels (2015) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 12: <br/>

//publicationslist.org/tobias.nef/refid460 2018-09-13T12:28:22Z

Bouncing a ball with a racket is a hybrid rhythmic-discrete motor task, combining continuous rhythmic racket movements with discrete impact events. Rhythmicity is exceptionally important in motor learning, because it underlies fundamental movements such as walking. Studies suggested that rhythmic and discrete movements are governed by different control mechanisms at different levels of the Central...<br/><br/>Laura Marchal-Crespo, Mathias Bannwart, Robert Riener, Heike Vallery (2015) <i>IEEE transactions on haptics</i> <i></i> <i></i> 8: 2 222-234<br/>

//publicationslist.org/tobias.nef/refid459 2018-09-13T12:28:22Z

Concurrent augmented feedback has been shown to be less effective for learning simple motor tasks than for complex tasks. However, as mostly artificial tasks have been investigated, transfer of results to tasks in sports and rehabilitation remains unknown. Therefore, in this study, the effect of different concurrent feedback was evaluated in trunk-arm rowing. It was then investigated whether multi...<br/><br/>Roland Sigrist, Georg Rauter, Laura Marchal-Crespo, Robert Riener, Peter Wolf (2015) <i>Experimental brain research</i> <i></i> <i></i> 233: 3 909-925<br/>

//publicationslist.org/tobias.nef/refid392 2018-06-25T13:25:46Z

The ability to determine what activity of daily living a person performs is of interest in many application domains. It is possible to determine the physical and cognitive capabilities of the elderly by inferring what activities they perform in their houses. Our primary aim was to establish a proof of concept that a wireless sensor system can monitor and record physical activity and these data can...<br/><br/>Prabitha Urwyler, Reto Stucki, Rene Muri, Urs P Mosimann, Tobias Nef (2015) <i>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</i> <i></i> <i></i> 2015: 8042-8045<br/>

//publicationslist.org/tobias.nef/refid395 2016-09-16T10:26:27Z

Crossing a street can be a very difficult task for older pedestrians. With increased age and potential cognitive decline, older people take the decision to cross a street primarily based on vehicles' distance, and not on their speed. Furthermore, older pedestrians tend to overestimate their own walking speed, and could not adapt it according to the traffic conditions. Pedestrians' behavior is ofte...<br/><br/>G A Zito, D Cazzoli, L Scheffler, M Jäger, R M Müri, U P Mosimann, T Nyffeler, F W Mast, T Nef (2015) <i>BMC geriatrics</i> <i></i> <i></i> 15: 1 <br/>

//publicationslist.org/tobias.nef/refid387 2015-12-16T14:56:51Z

The robotics-assisted tilt table (RATT), including actuators for tilting and cyclical leg movement, is used for rehabilitation of severely disabled neurological patients. Following further engineering development of the system, i.e. the addition of force sensors and visual bio-feedback, patients can actively participate in exercise testing and training on the device. Peak cardiopulmonary performan...<br/><br/>Jittima Saengsuwan, Tobias Nef, Marco Laubacher, Kenneth J Hunt (2015) <i>Biomedical engineering online</i> <i></i> <i></i> 14: 1 <br/>

//publicationslist.org/tobias.nef/refid386 2015-12-16T14:56:51Z

We aimed at further elucidating whether aphasic patients' difficulties in understanding non-canonical sentence structures, such as Passive or Object-Verb-Subject sentences, can be attributed to impaired morphosyntactic cue recognition, and to problems in integrating competing interpretations.<br/><br/>Rahel Schumacher, Dario Cazzoli, Noëmi Eggenberger, Basil Preisig, Tobias Nef, Thomas Nyffeler, Klemens Gutbrod, Jean-Marie Annoni, René M Müri (2015) <i>PloS one</i> <i></i> <i></i> 10: 11 <br/>

//publicationslist.org/tobias.nef/refid391 2015-12-16T14:58:06Z

In a high proportion of patients with favorable outcome after aneurysmal subarachnoid hemorrhage (aSAH), neuropsychological deficits, depression, anxiety, and fatigue are responsible for the inability to return to their regular premorbid life and pursue their professional careers. These problems often remain unrecognized, as no recommendations concerning a standardized comprehensive assessment hav...<br/><br/>Antoinette E Zweifel-Zehnder, Martin N Stienen, Christian Chicherio, Aline Studerus-Germann, Stefan Bläsi, Stefania Rossi, Klemens Gutbrod, Nicole Schmid, Valérie Beaud, Christian Mondadori, Peter Brugger, Leonardo Sacco, Rene Müri, Gerhard Hildebrandt, Jean-Yves Fournier, Emanuela Keller, Luca Regli, Javier Fandino, Luigi Mariani, Andreas Raabe, Roy Thomas Daniel, Michael Reinert, Thomas Robert, Bawarjan Schatlo, Philippe Bijlenga, Karl Schaller, Andreas U Monsch, (2015) <i>Acta neurochirurgica</i> <i></i> <i></i> 157: 9 1449-1458<br/>

//publicationslist.org/tobias.nef/refid388 2015-12-16T14:58:06Z

Roger Kalla, Jurka Meichtry, Rahel Schumacher, Dario Cazzoli, Roland Wiest, Eberhard Seifert, Rene Müri (2015) <i>JAMA neurology</i> <i></i> <i></i> : 1-2<br/>

//publicationslist.org/tobias.nef/refid390 2019-06-26T13:42:00Z

Referred to as orthographic depth, the degree of consistency of grapheme/phoneme correspondences varies across languages from high in shallow orthographies to low in deep orthographies. The present study investigates the impact of orthographic depth on reading route by analyzing evoked potentials to words in a deep (French) and shallow (German) language presented to highly proficient bilinguals. E...<br/><br/>Karin A Buetler, Diego de León Rodríguez, Marina Laganaro, René Müri, Thomas Nyffeler, Lucas Spierer, Jean-Marie Annoni (2015) <i>Brain and language</i> <i></i> <i></i> 150: 166-176<br/>

//publicationslist.org/tobias.nef/refid389 2015-12-16T14:58:06Z

Visual neglect is considerably exacerbated by increases in visual attentional load. These detrimental effects of attentional load are hypothesised to be dependent on an interplay between dysfunctional inter-hemispheric inhibitory dynamics and load-related modulation of activity in cortical areas such as the posterior parietal cortex (PPC). Continuous Theta Burst Stimulation (cTBS) over the contral...<br/><br/>Dario Cazzoli, Clive R Rosenthal, Christopher Kennard, Giuseppe A Zito, Simone Hopfner, René M Müri, Thomas Nyffeler (2015) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 73: 317-329<br/>

//publicationslist.org/tobias.nef/refid188 2014-04-02T05:44:41Z

Neuro-imaging studies have suggested that the ability to imitate meaningless and meaningful gestures may differentially depend on superior (SPL) and inferior (IPL) parietal lobule. Therefore, we hypothesized that imaging-guided neuro-navigated continuous theta burst stimulation (cTBS) over left SPL mainly affects meaningless and over left IPL predominantly meaningful gestures.<br/><br/>Tim Vanbellingen, Manuel Bertschi, Thomas Nyffeler, Dario Cazzoli, Roland Wiest, Claudio Bassetti, Alain Kaelin-Lang, René Müri, Stephan Bohlhalter (2014) <i>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</i> <i></i> <i></i> 125: 3 457-462<br/>

//publicationslist.org/tobias.nef/refid187 2014-05-23T10:35:38Z

To evaluate the feasibility and effectiveness of a comprehensive outpatient rehabilitation program combining secondary prevention and neurorehabilitation to improve vascular risk factors, neurologic functions, and health-related quality of life (HRQOL) in patients surviving a transient ischemic attack (TIA) or stroke with minor or no residual deficits.<br/><br/>Christian P Kamm, Jean-Paul Schmid, René M Müri, Heinrich P Mattle, Prisca Eser, Hugo Saner (2014) <i>Archives of physical medicine and rehabilitation</i> <i></i> <i></i> 95: 4 656-662<br/>

//publicationslist.org/tobias.nef/refid190 2015-09-18T09:33:53Z

Effective visual exploration is required for many activities of daily living and instruments to assess visual exploration are important for the evaluation of the visual and the oculomotor system. In this article, the development of a new instrument to measure central and peripheral target recognition is described. The measurement setup consists of a hemispherical projection which allows presenting...<br/><br/>T Nef, N Gruber, G A Zito, T Nyffeler, R Müri, U P Mosimann (2014) <i>Medical engineering & physics</i> <i></i> <i></i> 36: 4 490-495<br/>

//publicationslist.org/tobias.nef/refid192 2014-04-23T14:13:27Z

In patients with dementia, Behavioral and Psychological Symptoms of Dementia (BPSD) are frequent findings that accompany deficits caused by cognitive impairment and thus complicate diagnostics, therapy and care. BPSD are a burden both for affected individuals as well as care-givers, and represent a significant challenge for therapy of a patient population with high degree of multi-morbidity. The g...<br/><br/>Egemen Savaskan, Irene Bopp-Kistler, Markus Buerge, Regina Fischlin, Dan Georgescu, Umberto Giardini, Martin Hatzinger, Ulrich Hemmeter, Isabella Justiniano, Reto W Kressig, Andreas Monsch, Urs P Mosimann, Renè Mueri, Anna Munk, Julius Popp, Ruth Schmid, Marc A Wollmer (2014) <i>Praxis</i> <i></i> <i></i> 103: 3 135-148<br/>

//publicationslist.org/tobias.nef/refid185 2014-10-07T06:46:47Z

Systematic differences in circadian rhythmicity are thought to be a substantial factor determining inter-individual differences in fatigue and cognitive performance. The synchronicity effect (when time of testing coincides with the respective circadian peak period) seems to play an important role. Eye movements have been shown to be a reliable indicator of fatigue due to sleep deprivation or time ...<br/><br/>Dario Cazzoli, Chrystalina A Antoniades, Christopher Kennard, Thomas Nyffeler, Claudio L Bassetti, René M Müri (2014) <i>PloS one</i> <i></i> <i></i> 9: 1 <br/>

//publicationslist.org/tobias.nef/refid321 2014-05-23T07:39:57Z

Fatigue is a frequently reported symptom after a stroke. Although the phenomenology of poststroke fatigue is well known, clear definitions as well as diagnostic and therapeutic guidelines are missing. Poststroke fatigue can be regarded as a multidimensional phenomenon that might be influenced by neurological, physical, psychological, and cognitive factors. It can range from mild to severe and can ...<br/><br/>Hofer H, Grosse Holtforth M, Lüthy F, Frischknecht E, Znoj H, Müri RM (2014) <i>Mindfullness</i> 5: 2 192-199<br/>

//publicationslist.org/tobias.nef/refid191 2014-12-03T14:55:14Z

Armin von Gunten, Urs Peter Mosimann, Jean-Philippe Antonietti (2014) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 22: 4 420-421<br/>

//publicationslist.org/tobias.nef/refid169 2018-06-25T13:27:19Z

Visual symptoms are common in Parkinson's disease (PD) and are frequently under-diagnosed. The detection of visual symptoms is important for differential diagnosis and patient management.<br/><br/>Prabitha Urwyler, Tobias Nef, Alison Killen, Daniel Collerton, Alan Thomas, David Burn, Ian McKeith, Urs Peter Mosimann (2014) <i>Parkinsonism & related disorders</i> <i></i> <i></i> 20: 3 318-322<br/>

//publicationslist.org/tobias.nef/refid171 2014-03-31T06:46:54Z

Arm hemiparesis secondary to stroke is common and disabling. We aimed to assess whether robotic training of an affected arm with ARMin--an exoskeleton robot that allows task-specific training in three dimensions-reduces motor impairment more effectively than does conventional therapy.<br/><br/>Verena Klamroth-Marganska, Javier Blanco, Katrin Campen, Armin Curt, Volker Dietz, Thierry Ettlin, Morena Felder, Bernd Fellinghauer, Marco Guidali, Anja Kollmar, Andreas Luft, Tobias Nef, Corina Schuster-Amft, Werner Stahel, Robert Riener (2014) <i>Lancet neurology</i> <i></i> <i></i> 13: 2 159-166<br/>

//publicationslist.org/tobias.nef/refid158 2014-10-07T06:46:47Z

The assessment of driving-relevant cognitive functions in older drivers is a difficult challenge as there is no clear-cut dividing line between normal cognition and impaired cognition and not all cognitive functions are equally important for driving.<br/><br/>Rahel Bieri, Michael Jäger, Nicole Gruber, Tobias Nef, René M Müri, Urs P Mosimann (2014) <i>International psychogeriatrics / IPA</i> <i></i> <i></i> 26: 2 229-238<br/>

//publicationslist.org/tobias.nef/refid172 2014-03-26T08:53:29Z

Robotics-assisted tilt table technology was introduced for early rehabilitation of neurological patients. It provides cyclical stepping movement and physiological loading of the legs. The aim of the present study was to assess the feasibility of this type of device for peak cardiopulmonary performance testing using able-bodied subjects.METHODS: A robotics-assisted tilt table was augmented with for...<br/><br/>J Saengsuwan, M Laubacher, T Nef, K J Hunt (2014) <i>Technology and health care : official journal of the European Society for Engineering and Medicine</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid175 2014-03-31T06:46:54Z

Virtual reality testing of everyday activities is a novel type of computerized assessment that measures cognitive, executive, and motor performance as a screening tool for early dementia. This study used a virtual reality day-out task (VR-DOT) environment to evaluate its predictive value in patients with mild cognitive impairment (MCI).<br/><br/>Ioannis Tarnanas, Magda Tsolaki, Tobias Nef, René M Müri, Urs P Mosimann (2014) <i>Alzheimer's & dementia : the journal of the Alzheimer's Association</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid182 2014-04-02T05:44:41Z

Introduction: The orthographic depth hypothesis (Katz and Feldman, 1983) posits that different reading routes are engaged depending on the type of grapheme/phoneme correspondence of the language being read. Shallow orthographies with consistent grapheme/phoneme correspondences favor encoding via non-lexical pathways, where each grapheme is sequentially mapped to its corresponding phoneme. In contr...<br/><br/>Karin A Buetler, Diego de León Rodríguez, Marina Laganaro, René Müri, Lucas Spierer, Jean-Marie Annoni (2014) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid184 2014-04-02T05:44:41Z

This study investigated the roles of the right and left dorsolateral prefrontal (rDLPFC, lDLPFC) and the medial frontal cortex (MFC) in executive functioning using a theta burst transcranial magnetic stimulation (TMS) approach. Healthy subjects solved two visual search tasks: a number search task with low cognitive demands, and a number and letter search task with high cognitive demands. To observ...<br/><br/>Mathias Lüthi, Katharina Henke, Klemens Gutbrod, Thomas Nyffeler, Silvia Chaves, René M Müri (2014) <i>Frontiers in behavioral neuroscience</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid354 2014-07-21T12:37:22Z

A group of European experts was commissioned to establish guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) from evidence published up until March 2014, regarding pain, movement disorders, stroke, amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, consciousness disorders, tinnitus, depression, anxiety disorders, obsessive-compulsive disorder, schizo...<br/><br/>Jean-Pascal Lefaucheur, Nathalie André-Obadia, Andrea Antal, Samar S Ayache, Chris Baeken, David H Benninger, Roberto M Cantello, Massimo Cincotta, Mamede de Carvalho, Dirk De Ridder, Hervé Devanne, Vincenzo Di Lazzaro, Saša R Filipović, Friedhelm C Hummel, Satu K Jääskeläinen, Vasilios K Kimiskidis, Giacomo Koch, Berthold Langguth, Thomas Nyffeler, Antonio Oliviero, Frank Padberg, Emmanuel Poulet, Simone Rossi, Paolo Maria Rossini, John C Rothwell, Carlos Schönfeldt-Lecuona, Hartwig R Siebner, Christina W Slotema, Charlotte J Stagg, Josep Valls-Sole, Ulf Ziemann, Walter Paulus, Luis Garcia-Larrea (2014) <i>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid358 2014-07-24T12:59:34Z

The number of older adults in the global population is increasing. This demographic shift leads to an increasing prevalence of age-associated disorders, such as Alzheimer's disease and other types of dementia. With the progression of the disease, the risk for institutional care increases, which contrasts with the desire of most patients to stay in their home environment. Despite doctors' and careg...<br/><br/>Reto A Stucki, Prabitha Urwyler, Luca Rampa, René Müri, Urs P Mosimann, Tobias Nef (2014) <i>Journal of medical Internet research</i> <i></i> <i></i> 16: 7 <br/>

//publicationslist.org/tobias.nef/refid369 2015-04-28T11:54:30Z

Optimal identification of subtle cognitive impairment in the primary care setting requires a very brief tool combining (a) patients' subjective impairments, (b) cognitive testing, and (c) information from informants. The present study developed a new, very quick and easily administered case-finding tool combining these assessments ('BrainCheck') and tested the feasibility and validity of this inst...<br/><br/>Michael M Ehrensperger, Kirsten I Taylor, Manfred Berres, Nancy S Foldi, Myriam Dellenbach, Irene Bopp, Gabriel Gold, Armin von Gunten, Daniel Inglin, René Müri, Brigitte Rüegger, Reto W Kressig, Andreas U Monsch (2014) <i>Alzheimer's research & therapy</i> <i></i> <i></i> 6: 9 <br/>

//publicationslist.org/tobias.nef/refid461 2018-09-13T12:28:22Z

Reports about standardized and repeatable experimental procedures investigating supraspinal activation in patients with gait disorders are scarce in current neuro-imaging literature. Well-designed and executed tasks are important to gain insight into the effects of gait-rehabilitation on sensorimotor centers of the brain. The present study aims to demonstrate the feasibility of a novel imaging par...<br/><br/>Lukas Jaeger, Laura Marchal-Crespo, Peter Wolf, Robert Riener, Lars Michels, Spyros Kollias (2014) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 8: <br/>

//publicationslist.org/tobias.nef/refid364 2015-04-27T08:49:05Z

Textbooks divide between human memory systems based on consciousness. Hippocampus is thought to support only conscious encoding, while neocortex supports both conscious and unconscious encoding. We tested whether processing modes, not consciousness, divide between memory systems in three neuroimaging experiments with 11 amnesic patients (mean age=45.55 years, standard deviation=8.74, range=23-60) ...<br/><br/>Simone B Duss, Thomas P Reber, Jürgen Hänggi, Simon Schwab, Roland Wiest, René M Müri, Peter Brugger, Klemens Gutbrod, Katharina Henke (2014) <i>Brain : a journal of neurology</i> <i></i> <i></i> 137: Pt 12 3355-3370<br/>

//publicationslist.org/tobias.nef/refid361 2014-09-10T13:49:52Z

Lesions of the ventromedial prefrontal cortex can result in a deficient decision-making behavior. So far, most experimental results in the neuropsychological decision-making research have been obtained with gambling tasks. Due to their high complexity, it is difficult to evaluate the underlying processes of the decision-making deficits. The aim of this study was to assess if patients with ventrome...<br/><br/>Céline Eggen, Oswald Huber, Arlette Bär, Odilo W Huber, Walter J Perrig, René Müri, Klemens Gutbrod (2014) <i>Neurocase</i> <i></i> <i></i> : 1-11<br/>

//publicationslist.org/tobias.nef/refid360 2015-04-27T06:26:10Z

Higher visual functions can be defined as cognitive processes responsible for object recognition, color and shape perception, and motion detection. People with impaired higher visual functions after unilateral brain lesion are often tested with paper pencil tests, but such tests do not assess the degree of interaction between the healthy brain hemisphere and the impaired one. Hence, visual functio...<br/><br/>Giuseppe A Zito, René Müri, Urs P Mosimann, Thomas Nyffeler, Tobias Nef (2014) <i>Biomedical engineering online</i> <i></i> <i></i> 13: <br/>

//publicationslist.org/tobias.nef/refid357 2014-09-18T06:34:57Z

Lee Silverman Voice Treatment Big (LSVT BIG) is characterized by intensive exercising of high-amplitude movements to overcome bradykinesia and hypokinesia in patients with Parkinson disease (PD). The aim of the present case series was to explore possible beneficial effects of LSVT BIG training on gait, balance, bed mobility, and dexterity.<br/><br/>Jorina Janssens, Klaartje Malfroid, Thomas Nyffeler, Stephan Bohlhalter, Tim Vanbellingen (2014) <i>Physical therapy</i> <i></i> <i></i> 94: 7 1014-1023<br/>

//publicationslist.org/tobias.nef/refid458 2018-09-13T12:28:22Z

Research on motor learning has emphasized that errors drive motor adaptation. Thereby, several researchers have proposed robotic training strategies that amplify movement errors rather than decrease them. In this study, the effect of different robotic training strategies that amplify errors on learning a complex locomotor task was investigated. The experiment was conducted with a one degree-of fre...<br/><br/>Laura Marchal-Crespo, Jorge López-Olóriz, Lukas Jaeger, Robert Riener (2014) <i>Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference</i> <i></i> <i></i> 2014: 5304-5307<br/>

//publicationslist.org/tobias.nef/refid351 2015-04-27T06:26:10Z

User comfort during simulated driving is of key importance, since reduced comfort can confound the experiment and increase dropout rates. A common comfort-affecting factor is simulator-related transient adverse health effect (SHE). In this study, we propose and evaluate methods to adapt a virtual driving scene to reduce SHEs. In contrast to the manufacturer-provided high-sensory conflict scene (hi...<br/><br/>M Jäger, N Gruber, R Müri, U P Mosimann, T Nef (2014) <i>Medical & biological engineering & computing</i> <i></i> <i></i> 52: 7 601-610<br/>

//publicationslist.org/tobias.nef/refid352 2018-06-25T13:27:19Z

Much of the research on visual hallucinations (VHs) has been conducted in the context of eye disease and neurodegenerative conditions, but little is known about these phenomena in psychiatric and nonclinical populations. The purpose of this article is to bring together current knowledge regarding VHs in the psychosis phenotype and contrast this data with the literature drawn from neurodegenerative...<br/><br/>Flavie Waters, Daniel Collerton, Dominic H Ffytche, Renaud Jardri, Delphine Pins, Robert Dudley, Jan Dirk Blom, Urs Peter Mosimann, Frank Eperjesi, Stephen Ford, Frank Larøi (2014) <i>Schizophrenia bulletin</i> <i></i> <i></i> 40 Suppl 4: S233-S245<br/>

//publicationslist.org/tobias.nef/refid353 2015-01-29T10:23:43Z

Impaired manual dexterity is frequent and disabling in people with multiple sclerosis (MS). Therefore, convenient, quick, and validated tests for manual dexterity in people with MS are needed.<br/><br/>Mirjam R Heldner, Tim Vanbellingen, Stephan Bohlhalter, Heinrich P Mattle, René M Müri, Christian P Kamm (2014) <i>Physical therapy</i> <i></i> <i></i> 94: 11 1644-1651<br/>

//publicationslist.org/tobias.nef/refid164 2013-11-06T14:36:32Z

Visuoperceptual deficits are common in dementia with Lewy bodies (DLB) and Alzheimer disease (AD). Testing visuoperception in dementia is complicated by decline in other cognitive domains and extrapyramidal features. To overcome these issues, we developed a computerized test, the Newcastle visuoperception battery (NEVIP), which is independent of motor function and has minimal cognitive load.We aim...<br/><br/>Joshua S Wood, Michael J Firbank, Urs P Mosimann, Rosie Watson, Robert Barber, Andrew M Blamire, John T O'Brien (2013) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 21: 6 501-508<br/>

//publicationslist.org/tobias.nef/refid163 2014-03-31T06:46:54Z

Social networking sites can be beneficial for senior citizens to promote social participation and to enhance intergenerational communication. Particularly for older adults with impaired mobility, social networking sites can help them to connect with family members and other active social networking users. The aim of this systematic review is to give an overview of existing scientific literature on...<br/><br/>Tobias Nef, Raluca L Ganea, René M Müri, Urs P Mosimann (2013) <i>International psychogeriatrics / IPA</i> <i></i> <i></i> 25: 7 1041-1053<br/>

//publicationslist.org/tobias.nef/refid153 2013-03-20T15:45:20Z

Robotic exoskeletons can be used to study and treat patients with neurological impairments. They can guide and support the human limb over a large range of motion, which requires that the movement trajectory of the exoskeleton coincide with the one of the human arm. This is straightforward to achieve for rather simple joints like the elbow, but very challenging for complex joints like the human sh...<br/><br/>Tobias Nef, Robert Riener, René Müri, Urs P Mosimann (2013) <i>Med Biol Eng Comput</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid154 2013-11-06T14:36:32Z

Parkinson's disease, typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairment and dementia. Eye movement abnormalities are also described, including impairment of rapid eye movements (saccades) and the fixations interspersed between them. Such movements are under the influence of cortical and subcortical networks commonly targeted by the neurodegenera...<br/><br/>Neil K Archibald, Sam B Hutton, Michael P Clarke, Urs P Mosimann, David J Burn (2013) <i>Brain : a journal of neurology</i> <i></i> <i></i> 136: Pt 3 739-750<br/>

//publicationslist.org/tobias.nef/refid159 2014-05-23T10:35:38Z

Driving a car is a complex instrumental activity of daily living and driving performance is very sensitive to cognitive impairment. The assessment of driving-relevant cognition in older drivers is challenging and requires reliable and valid tests with good sensitivity and specificity to predict safe driving. Driving simulators can be used to test fitness to drive. Several studies have found strong...<br/><br/>Tobias Nef, René M Müri, Rahel Bieri, Michael Jäger, Nora Bethencourt, Ioannis Tarnanas, Urs P Mosimann (2013) <i>Journal of medical Internet research</i> <i></i> <i></i> 15: 10 <br/>

//publicationslist.org/tobias.nef/refid156 2013-11-06T14:36:32Z

Joanna M Jefferis, Michael P Clarke, Urs P Mosimann, John T O'Brien, John-Paul Taylor (2013) <i>Acta ophthalmologica</i> <i></i> <i></i> 91: 2 e159-e160<br/>

//publicationslist.org/tobias.nef/refid165 2018-06-25T13:27:19Z

To investigate the evolution of delirium of nursing home (NH) residents and their possible predictors.<br/><br/>Armin von Gunten, Urs Peter Mosimann, Jean-Philippe Antonietti (2013) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 21: 10 963-972<br/>

//publicationslist.org/tobias.nef/refid160 2014-07-11T10:06:35Z

Robot-assisted therapy has become increasingly common in neurorehabilitation. Sophisticated controllers have been developed for robots to assist and cooperate with the patient. It is difficult for the patient to judge to what extent the robot contributes to the execution of a movement. Therefore, methods to comprehensively quantify the patient's contribution and provide feedback are of key importa...<br/><br/>Marco Guidali, Urs Keller, Verena Klamroth-Marganska, Tobias Nef, Robert Riener (2013) <i>Journal of rehabilitation research and development</i> <i></i> <i></i> 50: 3 379-394<br/>

//publicationslist.org/tobias.nef/refid161 2014-07-11T10:09:13Z

Here, we review the effects of non-invasive brain stimulation such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) in the rehabilitation of neglect. We found 12 studies including 172 patients (10 TMS studies and 2 tDCS studies) fulfilling our search criteria. Activity of daily living measures such as the Barthel Index or, more specifically for neglect, ...<br/><br/>René Martin Müri, Dario Cazzoli, Tobias Nef, Urs P Mosimann, Simone Hopfner, Thomas Nyffeler (2013) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid155 2013-11-06T14:36:32Z

Background: visual and cognitive impairments are common in later life. Yet there are very few cognitive screening tests for the visually impaired. Objective: to screen for cognitive impairment in the visually impaired. Methods: case-control study including 150 elderly participants with visual impairment (n = 74) and a control group without visual impairment (n = 76) using vision-independent cognit...<br/><br/>Alison Killen, Michael J Firbank, Daniel Collerton, Michael Clarke, Joanna Mary Jefferis, John-Paul Taylor, Ian G McKeith, Urs Peter Mosimann (2013) <i>Age and ageing</i> <i></i> <i></i> 42: 1 98-102<br/>

//publicationslist.org/tobias.nef/refid162 2013-11-06T14:34:14Z

In this article, we review the impact of vision on older people's night driving abilities. Driving is the preferred and primary mode of transport for older people. It is a complex activity where intact vision is seminal for road safety. Night driving requires mesopic rather than scotopic vision, because there is always some light available when driving at night. Scotopic refers to night vision, ph...<br/><br/>Nicole Gruber, Urs P Mosimann, René M Müri, Tobias Nef (2013) <i>Traffic injury prevention</i> <i></i> <i></i> 14: 5 477-485<br/>

//publicationslist.org/tobias.nef/refid226 2014-05-09T11:16:02Z

Eye-movement abnormalities in schizophrenia are a well-established phenomenon that has been observed in many studies. In such studies, visual targets are usually presented in the center of the visual field, and the subject's head remains fixed. However, in every-day life, targets may also appear in the periphery. This study is among the first to investigate eye and head movements in schizophrenia ...<br/><br/>Simon Schwab, Othmar Würmle, Nadja Razavi, René M Müri, Andreas Altorfer (2013) <i>PloS one</i> <i></i> <i></i> 8: 9 <br/>

//publicationslist.org/tobias.nef/refid228 2014-05-09T11:16:02Z

Neuropsychological deficits (NPD) are common in patients with aneurysmal subarachnoid haemorrhage (aSAH). NPD are one of the major limiting factors for patients with an otherwise acceptable prognosis for sustained quality of life. There are only a few studies reporting outcome after aSAH, which used a standardized neuropsychological test battery as a primary or secondary outcome measure. Aim of th...<br/><br/>Martin N Stienen, Rahel Weisshaupt, Javier Fandino, Christian Fung, Emanuela Keller, Gerhard Hildebrandt, Aline Studerus-Germann, Rene Müri, Klemens Gutbrod, Stefan Bläsi, Andreas U Monsch, Peter Brugger, Christian Mondadori, Martin Sailer, Philippe Bijlenga, Karl Schaller, Bawarjan Schatlo, (2013) <i>Acta neurochirurgica</i> <i></i> <i></i> 155: 11 2045-2051<br/>

//publicationslist.org/tobias.nef/refid227 2014-09-18T06:34:57Z

Schizophrenia patients frequently present with subtle motor impairments, including higher order motor function such as hand gesture performance. Using cut off scores from a standardized gesture test, we previously reported gesture deficits in 40% of schizophrenia patients irrespective of the gesture content. However, these findings were based on normative data from an older control group. Hence, w...<br/><br/>Sebastian Walther, Tim Vanbellingen, René Müri, Werner Strik, Stephan Bohlhalter (2013) <i>Neuropsychologia</i> <i></i> <i></i> 51: 13 2674-2678<br/>

//publicationslist.org/tobias.nef/refid229 2014-05-09T11:16:02Z

The 2012 Swiss consensus paper on diagnosis and management of patients suffering from dementia resulted from the work of an expert panel who met on March 23d to 25th in Luzem. Based on a literature review, panel members wrote a first draft that was subsequently circulated among multiple dementia experts in Switzerland. After adaptation and revisions according to comments, all consulted dementia sp...<br/><br/>A U Monsch, C Büla, M Hermelink, R W Kressig, B Martensson, U Mosimann, R Müri, S Vögeli, A von Gunten, (2013) <i>Revue médicale suisse</i> <i></i> <i></i> 9: 382 838-847<br/>

//publicationslist.org/tobias.nef/refid230 2014-05-09T11:16:02Z

The purpose of the present study was to investigate whether amnesic patients show a bivalency effect. The bivalency effect refers to the performance slowing that occurs when switching tasks and bivalent stimuli appear occasionally among univalent stimuli. According to the episodic context binding account, bivalent stimuli create a conflict-loaded context that is re-activated on subsequent trials a...<br/><br/>Beat Meier, Alodie Rey-Mermet, Todd S Woodward, René Müri, Klemens Gutbrod (2013) <i>Neuropsychologia</i> <i></i> <i></i> 51: 5 886-892<br/>

//publicationslist.org/tobias.nef/refid234 2014-05-09T11:16:02Z

Gestures are important for nonverbal communication and were shown to be impaired in schizophrenia. Two categories of gestures can be differentiated: pantomime on verbal command and imitation of seen gestures. There is evidence that the neural basis of these domains may be distinct, pantomime being critically dependent on prefrontal cortex function. The aim of the study was to investigate gestural ...<br/><br/>Sebastian Walther, Tim Vanbellingen, René Müri, Werner Strik, Stephan Bohlhalter (2013) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 49: 2 520-527<br/>

//publicationslist.org/tobias.nef/refid149 2014-05-09T11:16:02Z

A 27-year-old patient with traumatic brain injury and neuropsychiatric symptoms fitting the obsessive-compulsive disorder was investigated. Brain CT-scan revealed left temporal and bilateral fronto-basal parenchymal contusions. Main Outcome Measure was the Yale-Brown Obsessive Compulsive Scale at pre- and post-treatment and at 6 months follow-up. The combination of pharmacotherapy and psychotherap...<br/><br/>Helene Hofer, Susanna Frigerio, Eveline Frischknecht, Daniel Gassmann, Klemens Gutbrod, René M Müri (2013) <i>Neurocase</i> <i></i> <i></i> 19: 4 390-400<br/>

//publicationslist.org/tobias.nef/refid225 2014-05-09T11:16:02Z

Mutations in the voltage-gated Cav2.1 P/Q-type calcium channel (CACNA1A) can cause a wide spectrum of phenotypes, including the episodic ataxia type 2. Beside the growing number of descriptions of novel CACNA1A mutations with episodic ataxia type 2 phenotype; there are only rare reports on interictal oculomotor signs other than nystagmus. We describe a novel CACNA1A mutation and an unclassified CA...<br/><br/>Stefan Kipfer, Simon Jung, Johannes R Lemke, Anna Kipfer-Kauer, Jeremy P Howell, Alain Kaelin-Lang, Thomas Nyffeler, Klemens Gutbrod, Angela Abicht, René M Müri (2013) <i>Journal of neurology</i> <i></i> <i></i> 260: 12 3010-3014<br/>

//publicationslist.org/tobias.nef/refid168 2014-02-15T09:35:30Z

The aim of this study was to examine the effects of aging and target eccentricity on a visual search task comprising 30 images of everyday life projected into a hemisphere, realizing a ±90° visual field. The task performed binocularly allowed participants to freely move their eyes to scan images for an appearing target or distractor stimulus (presented at 10°; 30°, and 50° eccentricity). The ...<br/><br/>Nicole Gruber, René M Müri, Urs P Mosimann, Rahel Bieri, Andrea Aeschimann, Giuseppe A Zito, Prabitha Urwyler, Thomas Nyffeler, Tobias Nef (2013) <i>Frontiers in aging neuroscience</i> <i></i> <i></i> 5: <br/>

//publicationslist.org/tobias.nef/refid167 2013-11-06T14:38:32Z

The parietal cortex is a critical interface for attention and integration of multiple sensory signals that can be used for the implementation of motor plans. Many neurons in this region exhibit strong attention-, reach-, grasp- or saccade-related activity. Here, we review human lesion studies supporting the critical role of the parietal cortex in saccade planning. Studies of patients with unilater...<br/><br/>Radek Ptak, René M Müri (2013) <i>Frontiers in human neuroscience</i> <i></i> <i></i> 7: <br/>

//publicationslist.org/tobias.nef/refid183 2014-04-02T05:44:41Z

The purpose of this study was to investigate the role of the fronto-striatal system for implicit task sequence learning. We tested performance of patients with compromised functioning of the fronto-striatal loops, that is, patients with Parkinson's disease and patients with lesions in the ventromedial or dorsolateral prefrontal cortex. We also tested amnesic patients with lesions either to the bas...<br/><br/>Beat Meier, Brigitte Weiermann, Klemens Gutbrod, Marianne A Stephan, Josephine Cock, René M Müri, Alain Kaelin-Lang (2013) <i>Neuropsychologia</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid186 2014-10-07T06:46:47Z

In the antisaccade task, subjects are requested to suppress a reflexive saccade towards a visual target and to perform a saccade towards the opposite side. In addition, in order to reproduce an accurate saccadic amplitude, the visual saccade vector (i.e., the distance between a central fixation point and the peripheral target) must be exactly inverted from one visual hemifield to the other. Result...<br/><br/>Katrin Jaun-Frutiger, Dario Cazzoli, René M Müri, Claudio L Bassetti, Thomas Nyffeler (2013) <i>PloS one</i> <i></i> <i></i> 8: 12 <br/>

//publicationslist.org/tobias.nef/refid189 2014-04-10T11:34:06Z

Background: Dementia is a multifaceted disorder that impairs cognitive functions, such as memory, language, and executive functions necessary to plan, organize, and prioritize tasks required for goal-directed behaviors. In most cases, individuals with dementia experience difficulties interacting with physical and social environments. The purpose of this study was to establish ecological validity a...<br/><br/>Ioannis Tarnanas, Winfried Schlee, Magda Tsolaki, René Müri, Urs Mosimann, Tobias Nef (2013) <i>JMIR Serious Games</i> 1: 1 e1<br/>

//publicationslist.org/tobias.nef/refid166 2014-05-09T11:13:56Z

This study aimed to test the prediction from the Perception and Attention Deficit model of complex visual hallucinations (CVH) that impairments in visual attention and perception are key risk factors for complex hallucinations in eye disease and dementia.<br/><br/>S M Makin, J Redman, U P Mosimann, R Dudley, M P Clarke, C Colbourn, D Collerton (2013) <i>International journal of geriatric psychiatry</i> <i></i> <i></i> 28: 12 1232-1238<br/>

//publicationslist.org/tobias.nef/refid147 2014-05-09T11:13:56Z

Visuo-perceptual abnormalities are a prominent feature in dementia with Lewy bodies (DLB) and also occur in Alzheimer's disease (AD) to a lesser extent. We studied the progression of visuo-perceptual abnormalities over a 12-month period in DLB and AD by using a novel computerised test battery.<br/><br/>Joshua S Wood, Rosie Watson, Michael J Firbank, Urs P Mosimann, Robert Barber, Andrew M Blamire, John T O'Brien (2013) <i>International journal of geriatric psychiatry</i> <i></i> <i></i> 28: 6 567-572<br/>

//publicationslist.org/tobias.nef/refid479 2019-06-26T13:42:00Z

Following prolonged exposure to adaptor sounds moving in a single direction, participants may perceive stationary-probe sounds as moving in the opposite direction [direction-selective auditory motion aftereffect (aMAE)] and be less sensitive to motion of any probe sounds that are actually moving (motion-sensitive aMAE). The neural mechanisms of aMAEs, and notably whether they are due to adaptation...<br/><br/>David A Magezi, Karin A Buetler, Leila Chouiter, Jean-Marie Annoni, Lucas Spierer (2013) <i>Journal of neurophysiology</i> <i></i> <i></i> 109: 2 321-331<br/>

//publicationslist.org/tobias.nef/refid232 2014-05-09T11:16:02Z

A U Monsch, C Büla, M Hermelink, R W Kressig, B Martensson, U Mosimann, R Müri, S Vögeli, A von Gunten, (2012) <i>Praxis</i> <i></i> <i></i> 101: 19 1239-1249<br/>

//publicationslist.org/tobias.nef/refid140 2012-09-04T14:17:29Z

Dario Cazzoli, Rahel Schumacher, Uli Baas, René M Müri, Roland Wiest, Stephan Bohlhalter, Christian W Hess, Thomas Nyffeler (2012) <i>Cortex</i> <i></i> <i></i> 48: 4 504-508<br/>

//publicationslist.org/tobias.nef/refid141 2012-04-12T10:48:20Z

Kamm CP, Heldner MR, Vanbellingen T, Mattle HP, Müri R, Bohlhalter S. Limb apraxia in multiple sclerosis: prevalence and impact on manual dexterity and activities of daily living. OBJECTIVE: To evaluate the prevalence and impact of limb apraxia on manual dexterity and activities of daily living (ADLs) in patients with multiple sclerosis (MS). DESIGN: Survey. SETTING: University hospital. PARTICIP...<br/><br/>Christian P Kamm, Mirjam R Heldner, Tim Vanbellingen, Heinrich P Mattle, René Müri, Stephan Bohlhalter (2012) <i>Arch Phys Med Rehabil</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid231 2014-09-10T14:06:34Z

The role of low-level stimulus-driven control in the guidance of overt visual attention has been difficult to establish because low- and high-level visual content are spatially correlated within natural visual stimuli. Here we show that impairment of parietal cortical areas, either permanently by a lesion or reversibly by repetitive transcranial magnetic stimulation (rTMS), leads to fixation of lo...<br/><br/>José P Ossandón, Selim Onat, Dario Cazzoli, Thomas Nyffeler, Rene Müri, Peter König (2012) <i>Neuropsychologia</i> <i></i> <i></i> 50: 14 3478-3487<br/>

//publicationslist.org/tobias.nef/refid138 2012-09-04T14:17:29Z

Stefan Kipfer, Christian Pirovino, Marwan El-Koussy, Thomas Nyffeler, Anton Lukes, René M Müri (2012) <i>Lancet</i> <i></i> <i></i> 379: 9830 <br/>

//publicationslist.org/tobias.nef/refid133 2012-09-04T14:14:12Z

Memory Clinics provide evidence based diagnosis and treatment of dementia. Whenever a diagnosis of dementia is made, it is important to inform the patients about the possible impact of dementia on driving. Patients and their next of kin require competent advice whenever this difficult question is addressed and the mobility desire and the risks related to driving need to be carefully weight up. The...<br/><br/>U P Mosimann, J Bächli-Biétry, J Boll, I Bopp-Kistler, F Donati, R W Kressig, B Martensson, A U Monsch, R Müri, T Nef, A Rothenberger, R Seeger, A von Gunten, U Wirz (2012) <i>Praxis (Bern 1994)</i> <i></i> <i></i> 101: 7 451-464<br/>

//publicationslist.org/tobias.nef/refid134 2012-09-04T14:14:12Z

Visual hallucinations (VH) are a common experience and can be distressing and disabling, particularly for people suffering from psychotic illness. However, not everyone with visual hallucinations reports the experience to be distressing. Models of VH propose that appraisals of VH as a threat to wellbeing and the use of safety seeking behaviours help maintain the distress.<br/><br/>Robert Dudley, Markku Wood, Helen Spencer, Alison Brabban, Urs P Mosimann, Daniel Collerton (2012) <i>Behav Cogn Psychother</i> <i></i> <i></i> 40: 3 367-375<br/>

//publicationslist.org/tobias.nef/refid233 2014-05-09T11:16:02Z

To evaluate the prevalence and impact of limb apraxia on manual dexterity and activities of daily living (ADLs) in patients with multiple sclerosis (MS).<br/><br/>Christian P Kamm, Mirjam R Heldner, Tim Vanbellingen, Heinrich P Mattle, René Müri, Stephan Bohlhalter (2012) <i>Archives of physical medicine and rehabilitation</i> <i></i> <i></i> 93: 6 1081-1085<br/>

//publicationslist.org/tobias.nef/refid139 2012-09-04T14:17:29Z

In the present multi-modal study we aimed to investigate the role of visual exploration in relation to the neuronal activity and performance during visuospatial processing. To this end, event related functional magnetic resonance imaging er-fMRI was combined with simultaneous eye tracking recording and transcranial magnetic stimulation (TMS). Two groups of twenty healthy subjects each performed an...<br/><br/>Silvia Chaves, Patrizia Vannini, Kay Jann, Pascal Wurtz, Andrea Federspiel, Thomas Nyffeler, Mathias Luethi, Daniela Hubl, Roland Wiest, Thomas Dierks, René M Müri (2012) <i>Neuroimage</i> <i></i> <i></i> 59: 4 3652-3661<br/>

//publicationslist.org/tobias.nef/refid142 2012-04-12T10:48:20Z

INTRODUCTION: Gestures are important for nonverbal communication and were shown to be impaired in schizophrenia. Two categories of gestures can be differentiated: pantomime on verbal command and imitation of seen gestures. There is evidence that the neural basis of these domains may be distinct, pantomime being critically dependent on prefrontal cortex function. The aim of the study was to investi...<br/><br/>Sebastian Walther, Tim Vanbellingen, René Müri, Werner Strik, Stephan Bohlhalter (2012) <i>Cortex</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid148 2013-03-20T15:53:27Z

Left-sided spatial neglect is a common neurological syndrome following right-hemispheric stroke. The presence of spatial neglect is a powerful predictor of poor rehabilitation outcome. In one influential account of spatial neglect, interhemispheric inhibition is impaired and leads to a pathological hyperactivity in the contralesional hemisphere, resulting in a biased attentional allocation towards...<br/><br/>Dario Cazzoli, René M Müri, Rahel Schumacher, Sebastian von Arx, Silvia Chaves, Klemens Gutbrod, Stephan Bohlhalter, Daniel Bauer, Tim Vanbellingen, Manuel Bertschi, Stefan Kipfer, Clive R Rosenthal, Christopher Kennard, Claudio L Bassetti, Thomas Nyffeler (2012) <i>Brain</i> <i></i> <i></i> 135: Pt 11 3426-3439<br/>

//publicationslist.org/tobias.nef/refid150 2013-03-20T15:53:27Z

Improvements of language production in aphasic patients have been reported following repeated 1-Hz transcranial magnetic stimulation over the nondamaged right hemisphere. Most studies examined aphasic patients in the chronic phase. The effect of transcranial magnetic stimulation application in acute or subacute patients has not been systematically studied. We aimed to evaluate whether continuous t...<br/><br/>Jochen Kindler, Rahel Schumacher, Dario Cazzoli, Klemens Gutbrod, Monica Koenig, Thomas Nyffeler, Thomas Dierks, René M Müri (2012) <i>Stroke</i> <i></i> <i></i> 43: 8 2175-2179<br/>

//publicationslist.org/tobias.nef/refid151 2014-05-09T11:16:02Z

For survivors of aneurysmal subarachnoid hemorrhage (SAH), somatic and cognitive deficits can affect long-term outcomes. We were interested in comparing the deficits identified in SAH patients, including cognitive deficits, at discharge by neurosurgeons and deficits identified by neurologists upon admission to the rehabilitation unit on the same day. The assessment of deficits might have an impact...<br/><br/>Christian Fung, Jürgen Beck, Lara Lauber, René Müri, Andreas Raabe, Thomas Nyffeler (2012) <i>Journal of neurology</i> <i></i> <i></i> 259: 10 2198-2201<br/>

//publicationslist.org/tobias.nef/refid235 2014-05-09T11:16:02Z

Valid assessment of apraxia in usually non-apraxic Parkinson's disease helps to delineate atypical parkinsonism frequently associated with apraxia. Furthermore, in a subgroup of late Parkinson's disease apraxia, typically the ideomotor subtype, may gradually superimpose onto parkinsonian motor symptoms contributing to defective manual skill. Here we evaluate the utility of a brief, standardized te...<br/><br/>T Vanbellingen, C Lungu, G Lopez, F Baronti, R Müri, M Hallett, S Bohlhalter (2012) <i>Parkinsonism & related disorders</i> <i></i> <i></i> 18: 4 348-350<br/>

//publicationslist.org/tobias.nef/refid119 2011-09-01T19:24:35Z

R Riener, M Guidali, U Keller, A Duschau-Wicke, V Klamroth,T Nef (2011) <i>Top Spinal Cord Inj Rehabil</i> 17(1): 54-59<br/>

//publicationslist.org/tobias.nef/refid113 2011-09-01T19:19:42Z

Acquired cataract and cognitive impairment are both common age-related problems, and ophthalmologists are increasingly likely to encounter patients who have both. Patients with dementia types who display early visuoperceptual impairment may present first to ophthalmology services. When these patients have coexisting cataract, it may be difficult to distinguish visual complaints due to cataract fro...<br/><br/>J M Jefferis, U P Mosimann, M P Clarke (2011) <i>Br J Ophthalmol</i> <i></i> <i></i> 95: 1 17-23<br/>

//publicationslist.org/tobias.nef/refid114 2011-09-01T19:35:47Z

To test the prediction by the Perception and Attention Deficit (PAD) model of complex visual hallucinations that cognitive impairment, specifically in visual attention, is a key risk factor for complex hallucinations in eye disease.<br/><br/>G Graham, J Dean, U P Mosimann, C Colbourn, R Dudley, M Clarke, D Collerton (2011) <i>Int J Geriatr Psychiatry</i> <i></i> <i></i> 26: 3 263-267<br/>

//publicationslist.org/tobias.nef/refid116 2012-09-04T14:20:06Z

In the past decade, several arm rehabilitation robots have been developed to assist neurological patients during therapy. Early devices were limited in their number of degrees of freedom and range of motion, whereas newer robots such as the ARMin robot can support the entire arm. Often, these devices are combined with virtual environments to integrate motivating game-like scenarios. Several studie...<br/><br/>Marco Guidali, Alexander Duschau-Wicke, Simon Broggi, Verena Klamroth-Marganska, Tobias Nef, Robert Riener (2011) <i>Med Biol Eng Comput</i> <i></i> <i></i> 49: 10 1213-1223<br/>

//publicationslist.org/tobias.nef/refid112 2011-09-01T19:34:18Z

In Switzerland, approximately 350,000 people aged 70 years or older own a valid driving license. By law, these drivers are medically assessed every other year, most commonly by their general practitioner, to exclude that a medical condition is interfering with their driving skills. A prerequisite for driving is the integration of high-level cognitive functions with perception and motor function. A...<br/><br/>JT Wagner, RM Müri, T Nef, UP Mosimann (2011) <i>Swiss Med Wkly</i> <i></i> <i></i> 140: <br/>

//publicationslist.org/tobias.nef/refid118 2012-09-04T14:20:06Z

A new overground body-weight support system called ZeroG has been developed that allows patients with severe gait impairments to practice gait and balance activities in a safe, controlled manner. The unloading system is capable of providing up to 300 lb of static support and 150 lb of dynamic (or constant force) support using a custom-series elastic actuator. The unloading system is mounted to a d...<br/><br/>Joseph Hidler, David Brennan, Iian Black, Diane Nichols, Kathy Brady, Tobias Nef (2011) <i>J Rehabil Res Dev</i> <i></i> <i></i> 48: 4 287-298<br/>

//publicationslist.org/tobias.nef/refid117 2012-09-04T14:20:06Z

We have developed a haptic-based approach for retraining of interjoint coordination following stroke called time-independent functional training (TIFT) and implemented this mode in the ARMin III robotic exoskeleton. The ARMin III robot was developed by Drs. Robert Riener and Tobias Nef at the Swiss Federal Institute of Technology Zurich (Eidgenossische Technische Hochschule Zurich, or ETH Zurich),...<br/><br/>Elizabeth B Brokaw, Theresa Murray, Tobias Nef, Peter S Lum (2011) <i>J Rehabil Res Dev</i> <i></i> <i></i> 48: 4 299-316<br/>

//publicationslist.org/tobias.nef/refid237 2014-05-09T11:16:02Z

Apraxia in patients with stroke may be overlooked, as clumsiness and deficient gestural communication are often attributed to frequently coexisting sensorimotor deficits and aphasia. Early and reliable detection of apraxia by a bedside test is relevant for functional outcome in patients with stroke. The present study was aimed at constructing a new bedside screening test for apraxia, called the Ap...<br/><br/>T Vanbellingen, B Kersten, A Van de Winckel, M Bellion, F Baronti, R Müri, S Bohlhalter (2011) <i>Journal of neurology, neurosurgery, and psychiatry</i> <i></i> <i></i> 82: 4 389-392<br/>

//publicationslist.org/tobias.nef/refid236 2014-05-09T11:16:02Z

A controversial concept suggests that impaired finger dexterity in Parkinson's disease may be related to limb kinetic apraxia that is not explained by elemental motor deficits such as bradykinesia. To explore the nature of dexterous difficulties, the aim of the present study was to assess the relationship of finger dexterity with ideomotor praxis function and parkinsonian symptoms. Twenty-five pat...<br/><br/>T Vanbellingen, B Kersten, M Bellion, P Temperli, F Baronti, R Müri, S Bohlhalter (2011) <i>Brain and cognition</i> <i></i> <i></i> 77: 1 48-52<br/>

//publicationslist.org/tobias.nef/refid363 2014-09-18T06:34:57Z

Apraxia is a higher-order motor disorder impairing the ability to correctly perform skilled, purposive movements as the result of neurological disorders most commonly stroke, dementia and movement disorders. It is increasingly recognised that apraxia negatively influences activities of daily living (ADL). Early diagnosis and treatment should be part of the neurorehabilitation programme. The aim of...<br/><br/>Tim Vanbellingen, Stephan Bohlhalter (2011) <i>NeuroRehabilitation</i> <i></i> <i></i> 28: 2 91-98<br/>

//publicationslist.org/tobias.nef/refid121 2011-09-01T19:37:05Z

To analyze oculomotor recovery in a patient with ischemic lesions restricted to the left frontal eye field (FEF) and the left parietal eye field (PEF).<br/><br/>T Nyffeler, D Hubl, P Wurtz, R Wiest, C W Hess, R M Müri (2011) <i>Clin Neurophysiol</i> <i></i> <i></i> 122: 6 1203-1210<br/>

//publicationslist.org/tobias.nef/refid109 2014-05-09T11:13:56Z

Joanna M Jefferis, Urs P Mosimann, John-Paul Taylor, Michael P Clarke (2011) <i>International psychogeriatrics / IPA</i> <i></i> <i></i> 23: 6 1014-1015<br/>

//publicationslist.org/tobias.nef/refid110 2012-09-04T14:14:12Z

Visuoperceptual deficits in dementia are common and can reduce quality of life. Testing of visuoperceptual function is often confounded by impairments in other cognitive domains and motor dysfunction. We aimed to develop, pilot, and test a novel visuocognitive prototype test battery which addressed these issues, suitable for both clinical and functional imaging use.<br/><br/>Joshua S Wood, Michael J Firbank, Urs P Mosimann, John-Paul Taylor, John T O'Brien (2011) <i>J Geriatr Psychiatry Neurol</i> <i></i> <i></i> 24: 2 73-83<br/>

//publicationslist.org/tobias.nef/refid111 2012-09-04T14:14:12Z

Visual symptoms are common in Parkinson's disease with studies consistently demonstrating reductions in visual acuity, contrast sensitivity, colour and motion perception as well as alterations in electroretinogram latencies and amplitudes. Optical coherence tomography can examine retinal structure non-invasively and retinal thinning has been suggested as a potential biomarker for neurodegeneration...<br/><br/>N K Archibald, M P Clarke, U P Mosimann, D J Burn (2011) <i>Parkinsonism Relat Disord</i> <i></i> <i></i> 17: 6 431-436<br/>

//publicationslist.org/tobias.nef/refid120 2012-09-04T14:17:29Z

Neglect is defined as the failure to attend and to orient to the contralesional side of space. A horizontal bias towards the right visual field is a classical finding in patients who suffered from a right-hemispheric stroke. The vertical dimension of spatial attention orienting has only sparsely been investigated so far. The aim of this study was to investigate the specificity of this vertical bia...<br/><br/>Dario Cazzoli, Thomas Nyffeler, Christian W Hess, René M Müri (2011) <i>Neuropsychologia</i> <i></i> <i></i> 49: 9 2369-2374<br/>

//publicationslist.org/tobias.nef/refid322 2014-05-23T07:44:04Z

Müri RM, Nyffeler T (2011) <i>The Oxford Handbook of Eye Movements</i> <br/>

//publicationslist.org/tobias.nef/refid157 2013-03-20T15:55:56Z

Acquired cataract and cognitive impairment are both common age-related problems, and ophthalmologists are increasingly likely to encounter patients who have both. Patients with dementia types who display early visuoperceptual impairment may present first to ophthalmology services. When these patients have coexisting cataract, it may be difficult to distinguish visual complaints due to cataract fro...<br/><br/>J M Jefferis, U P Mosimann, M P Clarke (2011) <i>Postgrad Med J</i> <i></i> <i></i> 87: 1031 636-642<br/>

//publicationslist.org/tobias.nef/refid137 2012-04-12T10:44:46Z

Psychotropic medication is commonly used in nursing homes, to treat behavioural and psychological symptoms of dementia (BPSD) for example. Treatment with antipsychotics may improve BPSD in some residents but can be associated with serious side effects, such as higher mortality, faster disease progression and cerebrovascular events. In the current study, psychotropic medication use was analysed in ...<br/><br/>I Lustenberger, B Schüpbach, A von Gunten, U Mosimann (2011) <i>Swiss Med Wkly</i> <i></i> <i></i> 141: <br/>

//publicationslist.org/tobias.nef/refid136 2012-04-12T10:43:52Z

Acquired cataract and cognitive impairment are both common age-related problems, and ophthalmologists are increasingly likely to encounter patients who have both. Patients with dementia types who display early visuoperceptual impairment may present first to ophthalmology services. When these patients have coexisting cataract, it may be difficult to distinguish visual complaints due to cataract fro...<br/><br/>J M Jefferis, U P Mosimann, M P Clarke (2011) <i>Postgrad Med J</i> <i></i> <i></i> 87: 1031 636-642<br/>

//publicationslist.org/tobias.nef/refid130 2011-09-01T19:29:29Z

Apraxia in patients with stroke may be overlooked, as clumsiness and deficient gestural communication are often attributed to frequently coexisting sensorimotor deficits and aphasia. Early and reliable detection of apraxia by a bedside test is relevant for functional outcome in patients with stroke. The present study was aimed at constructing a new bedside screening test for apraxia, called the Ap...<br/><br/>T Vanbellingen, B Kersten, A Van de Winckel, M Bellion, F Baronti, R Müri, S Bohlhalter (2011) <i>J Neurol Neurosurg Psychiatry</i> <i></i> <i></i> 82: 4 389-392<br/>

//publicationslist.org/tobias.nef/refid135 2012-04-12T10:43:52Z

Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize...<br/><br/>Neil K Archibald, Mike P Clarke, Urs P Mosimann, David J Burn (2011) <i>Mov Disord</i> <i></i> <i></i> 26: 13 2387-2395<br/>

//publicationslist.org/tobias.nef/refid174 2014-05-27T06:44:39Z

The cognitive mechanisms underlying personal neglect are not well known. One theory postulates that personal neglect is due to a disorder of contralesional body representation. In the present study, we have investigated whether personal neglect is best explained by impairments in the representation of the contralesional side of the body, in particular, or a dysfunction of the mental representation...<br/><br/>Ulrike Baas, Bianca de Haan, Tanja Grässli, Hans-Otto Karnath, René Mueri, Walter J Perrig, Pascal Wurtz, Klemens Gutbrod (2011) <i>Neuropsychologia</i> <i></i> <i></i> 49: 5 898-905<br/>

//publicationslist.org/tobias.nef/refid143 2012-04-12T10:48:20Z

BACKGROUND: Valid assessment of apraxia in usually non-apraxic Parkinson's disease helps to delineate atypical parkinsonism frequently associated with apraxia. Furthermore, in a subgroup of late Parkinson's disease apraxia, typically the ideomotor subtype, may gradually superimpose onto parkinsonian motor symptoms contributing to defective manual skill. Here we evaluate the utility of a brief, sta...<br/><br/>T Vanbellingen, C Lungu, G Lopez, F Baronti, R Müri, M Hallett, S Bohlhalter (2011) <i>Parkinsonism Relat Disord</i> <i></i> <i></i> : <br/>

//publicationslist.org/tobias.nef/refid128 2011-09-01T19:29:29Z

A controversial concept suggests that impaired finger dexterity in Parkinson's disease may be related to limb kinetic apraxia that is not explained by elemental motor deficits such as bradykinesia. To explore the nature of dexterous difficulties, the aim of the present study was to assess the relationship of finger dexterity with ideomotor praxis function and parkinsonian symptoms. Twenty-five pat...<br/><br/>T Vanbellingen, B Kersten, M Bellion, P Temperli, F Baronti, R Müri, S Bohlhalter (2011) <i>Brain Cogn</i> <i></i> <i></i> 77: 1 48-52<br/>

//publicationslist.org/tobias.nef/refid129 2011-09-01T19:37:42Z

The traditional view of a predominant inferior parietal representation of gestures has been recently challenged by neuroimaging studies demonstrating that gesture production and discrimination may critically depend on inferior frontal lobe function. The aim of the present work was therefore to investigate the effect of transient disruption of these brain sites by continuous theta burst stimulation...<br/><br/>S Bohlhalter, T Vanbellingen, M Bertschi, P Wurtz, D Cazzoli, T Nyffeler, C W Hess, R Müri (2011) <i>Clin Neurophysiol</i> <i></i> <i></i> 122: 6 1197-1202<br/>

//publicationslist.org/tobias.nef/refid123 2011-09-01T19:38:52Z

Cerebral achromatopsia is a rare disorder of colour vision caused by bilateral damage to the occipito-temporal cortex. Patients with cerebral achromatopsia are commonly said to suffer due to their disturbed colour sense. Here, we report the case of a patient with cerebral achromatopsia who was initially unaware of his deficit, although three experiments with eye movement recordings demonstrated hi...<br/><br/>S W von Arx, R M Müri, D Heinemann, C W Hess, T Nyffeler (2010) <i>Neuropsychologia</i> <i></i> <i></i> 48: 4 970-977<br/>

//publicationslist.org/tobias.nef/refid449 2018-06-25T13:27:19Z

Understanding of visual hallucinations is developing rapidly. Single-factor explanations based on specific pathologies have given way to complex multifactor models with wide potential applicability. Clinical studies of disorders with frequent hallucinations-dementia, delirium, eye disease and psychosis-show that dysfunction within many parts of the distributed ventral object perception system is a...<br/><br/>Daniel Collerton, Urs Peter Mosimann (2010) <i>Wiley interdisciplinary reviews. Cognitive science</i> <i></i> <i></i> 1: 6 781-786<br/>

//publicationslist.org/tobias.nef/refid239 2014-05-09T11:16:02Z

Only few standardized apraxia scales are available and they do not cover all domains and semantic features of gesture production. Therefore, the objective of the present study was to evaluate the reliability and validity of a newly developed test of upper limb apraxia (TULIA), which is comprehensive and still short to administer.<br/><br/>T Vanbellingen, B Kersten, B Van Hemelrijk, A Van de Winckel, M Bertschi, R Müri, W De Weerdt, S Bohlhalter (2010) <i>European journal of neurology : the official journal of the European Federation of Neurological Societies</i> <i></i> <i></i> 17: 1 59-66<br/>

//publicationslist.org/tobias.nef/refid146 2012-04-12T11:06:19Z

T Nyffeler, RM Müri, D. Cazzoli (2010) <i>Schweizer Archiv für Neurologie</i> 161: 250-253<br/>

//publicationslist.org/tobias.nef/refid144 2012-04-12T11:03:27Z

Only few standardized apraxia scales are available and they do not cover all domains and semantic features of gesture production. Therefore, the objective of the present study was to evaluate the reliability and validity of a newly developed test of upper limb apraxia (TULIA), which is comprehensive and still short to administer.<br/><br/>T Vanbellingen, B Kersten, B Van Hemelrijk, A Van de Winckel, M Bertschi, R Müri, W De Weerdt, S Bohlhalter (2010) <i>Eur J Neurol</i> <i></i> <i></i> 17: 1 59-66<br/>

//publicationslist.org/tobias.nef/refid145 2012-04-12T11:04:34Z

When healthy observers make a saccade that is erroneously directed toward a distracter stimulus, they often produce a corrective saccade within 100ms after the end of the primary saccade. Such short inter-saccadic intervals indicate that programming of the secondary saccade has been initiated prior to the execution of the primary saccade and hence that the two saccades have been programmed concurr...<br/><br/>Radek Ptak, Armin Schnider, René Müri (2010) <i>Neuropsychologia</i> <i></i> <i></i> 48: 4 880-886<br/>

//publicationslist.org/tobias.nef/refid131 2011-09-01T19:39:14Z

Synaesthesia is a condition in which the input of one sensory modality triggers extraordinary additional experiences. On an explicit level, subjects affected by this condition normally report unidirectional experiences. In grapheme-colour synaesthesia for example, the letter A printed in black may trigger a red colour experience but not vice versa. However on an implicit level, at least for some t...<br/><br/>N Rothen, T Nyffeler, R von Wartburg, R Müri, B Meier (2010) <i>Neuropsychologia</i> <i></i> <i></i> 48: 12 3482-3487<br/>

//publicationslist.org/tobias.nef/refid132 2011-09-01T19:39:26Z

T Nyffeler, R Müri (2010) <i>Clin Neurophysiol</i> <i></i> <i></i> 121: 6 <br/>

//publicationslist.org/tobias.nef/refid115 2011-09-01T19:38:07Z

We wished to investigate the prevalence of delirium in patients upon admission to nursing homes and whether or not the previous place of residence predicts delirium.<br/><br/>A von Gunten, UP Mosimann (2010) <i>Swiss Med Wkly</i> <i></i> <i></i> 140: 25-26 376-381<br/>

//publicationslist.org/tobias.nef/refid122 2011-09-01T19:38:29Z

Hemispatial neglect - defined as the failure to attend, explore, and act upon the contralesional side of space - is a frequent and disabling neurological syndrome. Interhemispheric rivalry is considered as a major pathophysiological mechanism underlying hemispatial neglect. According to this account, the contralesional, intact hemisphere undergoes a pathological hyperactivity due to a deficient tr...<br/><br/>D Cazzoli, RM Müri, CW Hess, T Nyffeler (2010) <i>Restor Neurol Neurosci</i> <i></i> <i></i> 28: 4 499-510<br/>

//publicationslist.org/tobias.nef/refid240 2014-05-09T11:16:02Z

Visual neglect is a frequent disability in stroke and adversely affects mobility, discharge destination, and length of hospital stay. It is assumed that its severity is enhanced by a released interhemispheric inhibition from the unaffected toward the affected hemisphere. Continuous theta burst transcranial magnetic stimulation (TBS) is a new inhibitory brain stimulation protocol which has the pote...<br/><br/>Thomas Nyffeler, Dario Cazzoli, Christian W Hess, René M Müri (2009) <i>Stroke; a journal of cerebral circulation</i> <i></i> <i></i> 40: 8 2791-2796<br/>

//publicationslist.org/tobias.nef/refid238 2016-05-09T06:19:18Z

After a lesion of the posterior parietal cortex (PPC), the perception of a contra-lesional stimulus in presence of a simultaneous, ipsilesional stimulus may be impaired, a phenomenon referred to as visual extinction. In the present study, visual extinction was transiently induced in healthy subjects by interfering with the function of the right PPC by means of continuous theta burst stimulation (T...<br/><br/>D Cazzoli, R M Müri, C W Hess, T Nyffeler (2009) <i>Neuroscience</i> <i></i> <i></i> 164: 4 1609-1614<br/>

//publicationslist.org/tobias.nef/refid241 2014-05-09T11:16:02Z

Interhemispheric imbalance is discussed as a pathophysiological mechanism in visuospatial neglect. It is suggested that after a lesion of the right hemisphere the mutual transcallosal inhibition is impaired, resulting in an increased activity of the left hemisphere. We investigated the interhemispheric balance of attention in healthy subjects by using a free visual exploration task and by interfer...<br/><br/>Dario Cazzoli, Pascal Wurtz, René M Müri, Christian W Hess, Thomas Nyffeler (2009) <i>The European journal of neuroscience</i> <i></i> <i></i> 29: 6 1271-1276<br/>

//publicationslist.org/tobias.nef/refid242 2014-05-09T11:16:02Z

Despite their relevance for locomotion and social interaction in everyday situations, little is known about the cortical control of vertical saccades in humans. Results from microstimulation studies indicate that both frontal eye fields (FEFs) contribute to these eye movements. Here, we present a patient with a damaged right FEF, who hardly made vertical saccades during visual exploration. This fi...<br/><br/>Tobias Pflugshaupt, Thomas Nyffeler, Roman von Wartburg, Christian W Hess, René M Müri (2009) <i>BMJ case reports</i> <i></i> <i></i> 2009: <br/>

//publicationslist.org/tobias.nef/refid244 2014-05-09T11:16:02Z

When we actively explore the visual environment, our gaze preferentially selects regions characterized by high contrast and high density of edges, suggesting that the guidance of eye movements during visual exploration is driven to a significant degree by perceptual characteristics of a scene. Converging findings suggest that the selection of the visual target for the upcoming saccade critically d...<br/><br/>Radek Ptak, Laetitia Golay, René M Müri, Armin Schnider (2009) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 45: 10 1156-1166<br/>

//publicationslist.org/tobias.nef/refid243 2016-05-09T06:20:05Z

The analysis of eye movement parameters in visual neglect such as cumulative fixation duration, saccade amplitude, or the numbers of saccades has been used to probe attention deficits in neglect patients, since the pattern of exploratory eye movements has been taken as a strong index of attention distribution. The current overview of the literature of visual neglect has its emphasis on studies dea...<br/><br/>René M Müri, D Cazzoli, T Nyffeler, T Pflugshaupt (2009) <i>Psychological research</i> <i></i> <i></i> 73: 2 147-157<br/>

//publicationslist.org/tobias.nef/refid178 2014-03-31T06:46:54Z

Many rehabilitation robots use electric motors with gears. The backdrivability of geared drives is poor due to friction. While it is common practice to use velocity measurements to compensate for kinetic friction, breakaway friction usually cannot be compensated for without the use of an additional force sensor that directly measures the interaction force between the human and the robot. Therefore...<br/><br/>Tobias Nef, Peter Lum (2009) <i>Medical & biological engineering & computing</i> <i></i> <i></i> 47: 4 441-447<br/>

//publicationslist.org/tobias.nef/refid177 2014-03-31T06:46:54Z

Several clinical studies on chronic stroke conducted with end-effector-based robots showed improvement of the motor function in the affected arm. Compared to end-effector-based robots, exoskeleton robots provide improved guidance of the human limb and are better suited to train task-oriented movements with a large range of motions.<br/><br/>Tobias Nef, Gabriela Quinter, Roland Müller, Robert Riener (2009) <i>Neuro-degenerative diseases</i> <i></i> <i></i> 6: 5-6 240-251<br/>

//publicationslist.org/tobias.nef/refid323 2014-05-23T09:51:23Z

Schmitt WJ, Müri RM (2009) <i>Schweizer Archiv für Neurologie</i> 160: 352-355<br/>

//publicationslist.org/tobias.nef/refid221 2014-05-23T11:37:10Z

Pure alexia is an acquired reading disorder characterized by a disproportionate prolongation of reading time as a function of word length. Although the vast majority of cases reported in the literature show a right-sided visual defect, little is known about the contribution of this low-level visual impairment to their reading difficulties. The present study was aimed at investigating this issue by...<br/><br/>Tobias Pflugshaupt, Klemens Gutbrod, Pascal Wurtz, Roman von Wartburg, Thomas Nyffeler, Bianca de Haan, Hans-Otto Karnath, René M Mueri (2009) <i>Brain : a journal of neurology</i> <i></i> <i></i> 132: Pt 7 1907-1917<br/>

//publicationslist.org/tobias.nef/refid222 2014-10-07T06:50:34Z

When sight-reading a piece of music the eyes constantly scan the score slightly ahead of music execution. This separation between reading and acting is commonly termed eye-hand span and can be expressed in two ways: as anticipation in notes or in time. Previous research, predominantly in piano players, found skill-dependent differences of eye-hand span. To date no study has explored visual anticip...<br/><br/>Pascal Wurtz, René M Mueri, Mario Wiesendanger (2009) <i>Experimental brain research</i> <i></i> <i></i> 194: 3 445-450<br/>

//publicationslist.org/tobias.nef/refid223 2014-05-23T09:54:56Z

Based on neurophysiological findings and a grid to score binocular visual field function, two hypotheses concerning the spatial distribution of fixations during visual search were tested and confirmed in healthy participants and patients with homonymous visual field defects. Both groups showed significant biases of fixations and viewing time towards the centre of the screen and the upper screen ha...<br/><br/>Tobias Pflugshaupt, Roman von Wartburg, Pascal Wurtz, Silvia Chaves, Anouk Déruaz, Thomas Nyffeler, Sebastian von Arx, Mathias Luethi, Dario Cazzoli, René M Mueri (2009) <i>Vision research</i> <i></i> <i></i> 49: 2 237-248<br/>

//publicationslist.org/tobias.nef/refid194 2014-05-09T11:13:56Z

A 78-year-old female developed memory problems after a 2-year history of persistent visual complaints. Ocular pathology did not explain the extent of her perceived visual impairment. Cognitive screening tests found prominent visuo-constructive deficits and a comprehensive dementia assessment revealed the diagnosis of Alzheimer's disease. This case describes visual complaints as the initial symptom...<br/><br/>Nikolaos Koutroumanos, Michael P Clarke, Urs Peter Mosimann (2009) <i>BMJ case reports</i> <i></i> <i></i> 2009: <br/>

//publicationslist.org/tobias.nef/refid193 2014-05-09T11:13:56Z

As a more complete picture of the clinical phenotype of Parkinson's disease emerges, non-motor symptoms have become increasingly studied. Prominent among these non-motor phenomena are mood disturbance, cognitive decline and dementia, sleep disorders, hyposmia and autonomic failure. In addition, visual symptoms are common, ranging from complaints of dry eyes and reading difficulties, through to per...<br/><br/>Neil K Archibald, Michael P Clarke, Urs P Mosimann, David J Burn (2009) <i>Brain : a journal of neurology</i> <i></i> <i></i> 132: Pt 5 1128-1145<br/>

//publicationslist.org/tobias.nef/refid176 2014-03-31T06:46:54Z

Robot-assisted therapy offers a promising approach to neurorehabilitation, particularly for severely to moderately impaired stroke patients. The objective of this study was to investigate the effects of intensive arm training on motor performance in four chronic stroke patients using the robot ARMin II.<br/><br/>Patricia Staubli, Tobias Nef, Verena Klamroth-Marganska, Robert Riener (2009) <i>Journal of neuroengineering and rehabilitation</i> <i></i> <i></i> 6: <br/>

//publicationslist.org/tobias.nef/refid195 2014-05-09T11:13:56Z

Visual hallucinations are under-reported by patients and are often undiscovered by health professionals. There is no gold standard available to assess hallucinations. Our objective was to develop a reliable, valid, semi-structured interview for identifying and assessing visual hallucinations in older people with eye disease and cognitive impairment.<br/><br/>Urs Peter Mosimann, Daniel Collerton, Robert Dudley, Thomas Daniel Meyer, Gemma Graham, Jennifer Louise Dean, Daniel Bearn, Alison Killen, Lucy Dickinson, Mike Patrick Clarke, Ian Grant McKeith (2008) <i>International journal of geriatric psychiatry</i> <i></i> <i></i> 23: 7 712-718<br/>

//publicationslist.org/tobias.nef/refid245 2014-05-23T10:01:33Z

This review discusses the neurophysiology and neuroanatomy of the cortical control of reflexive and volitional saccades in humans. The main focus is on classical lesion studies and studies using the interference method of transcranial magnetic stimulation (TMS). To understand the behavioural function of a region, it is essential to assess oculomotor deficits after a focal lesion using a variety of...<br/><br/>René M Müri, Thomas Nyffeler (2008) <i>Brain and cognition</i> <i></i> <i></i> 68: 3 284-292<br/>

//publicationslist.org/tobias.nef/refid248 2014-05-09T11:16:02Z

The right posterior parietal cortex (PPC) is critically involved in visual exploration behaviour, and damage to this area may lead to neglect of the left hemispace. We investigated whether neglect-like visual exploration behaviour could be induced in healthy subjects using theta burst repetitive transcranial magnetic stimulation (rTMS). To this end, one continuous train of theta burst rTMS was app...<br/><br/>Thomas Nyffeler, Dario Cazzoli, Pascal Wurtz, Mathias Lüthi, Roman von Wartburg, Silvia Chaves, Anouk Déruaz, Christian W Hess, René M Müri (2008) <i>The European journal of neuroscience</i> <i></i> <i></i> 27: 7 1809-1813<br/>

//publicationslist.org/tobias.nef/refid333 2014-05-23T11:59:58Z

Müri RM, Nyffeler T. (2008) <i>Prog Brain Res 171:</i> 413-8<br/>

//publicationslist.org/tobias.nef/refid324 2014-05-23T10:39:50Z

Déruaz A, Safran AB, Sutter M, Müri RM (2008) <i>Clinical Medicine: Geriatrics</i> 2: 21–30<br/>

//publicationslist.org/tobias.nef/refid246 2014-05-09T11:16:02Z

In the memory antisaccade task, subjects are instructed to look at an imaginary point precisely at the opposite side of a peripheral visual stimulus presented short time previously. To perform this task accurately, the visual vector, i.e., the distance between a central fixation point and the peripheral stimulus, must be inverted from one visual hemifield to the other. Recent data in humans and mo...<br/><br/>Thomas Nyffeler, Mathias Hartmann, Christian W Hess, René M Müri (2008) <i>Progress in brain research</i> <i></i> <i></i> 171: 429-432<br/>

//publicationslist.org/tobias.nef/refid251 2014-05-09T11:16:02Z

The aim of the current study was to examine the effect of theta burst repetitive transcranial magnetic stimulation (rTMS) on the blood oxygenation level-dependent (BOLD) activation during repeated functional magnetic resonance imaging (fMRI) measurements. Theta burst rTMS was applied over the right frontal eye field in seven healthy subjects. Subsequently, repeated fMRI measurements were performed...<br/><br/>D Hubl, T Nyffeler, P Wurtz, S Chaves, T Pflugshaupt, M Lüthi, R von Wartburg, R Wiest, T Dierks, W K Strik, C W Hess, R M Müri (2008) <i>Neuroscience</i> <i></i> <i></i> 151: 3 921-928<br/>

//publicationslist.org/tobias.nef/refid252 2014-05-09T11:16:02Z

Despite their relevance for locomotion and social interaction in everyday situations, little is known about the cortical control of vertical saccades in humans. Results from microstimulation studies indicate that both frontal eye fields (FEFs) contribute to these eye movements. Here, we present a patient with a damaged right FEF, who hardly made vertical saccades during visual exploration. This fi...<br/><br/>T Pflugshaupt, T Nyffeler, R von Wartburg, C W Hess, R M Müri (2008) <i>Journal of neurology, neurosurgery, and psychiatry</i> <i></i> <i></i> 79: 4 474-477<br/>

//publicationslist.org/tobias.nef/refid247 2014-05-09T11:16:02Z

Decision-making and memory are fundamental processes for successful human behaviour. For eye movements, the frontal eye fields (FEF), the supplementary eye fields (SEF), the dorsolateral prefrontal cortex (DLPFC), the ventrolateral frontal cortex and the anterior cingulum are important for these cognitive processes. The online approach of transcranial magnetic stimulation (TMS), i.e., the applicat...<br/><br/>René M Müri, Thomas Nyffeler (2008) <i>Progress in brain research</i> <i></i> <i></i> 171: 413-418<br/>

//publicationslist.org/tobias.nef/refid249 2014-05-09T11:16:02Z

Theta burst transcranial magnetic stimulation (TBS) may induce behavioural changes that outlast the stimulation period. The neurophysiological basis of these behavioural changes are currently under investigation. Given the evidence that cortical information processing relies on transient synchronization and desynchronization of neuronal assemblies, we set out to test whether TBS is associated with...<br/><br/>Kaspar Schindler, Thomas Nyffeler, Roland Wiest, Martinus Hauf, Johannes Mathis, Ch W Hess, René Müri (2008) <i>Neuroscience letters</i> <i></i> <i></i> 436: 1 31-34<br/>

//publicationslist.org/tobias.nef/refid250 2014-05-09T11:16:02Z

The key feature of Ganser's syndrome includes approximate answers to simple questions. The cause of this rare syndrome remains uncertain. Current classification systems categorise it as a dissociative disorder, the symptoms of which are judged as psychogenic in origin. Our review of the literature (n=151) demonstrates however that Ganser's syndrome is frequently associated with brain injury, altho...<br/><br/>G Wirtz, U Baas, H Hofer, T Nyffeler, E Seifritz, R Müri, K Gutbrod (2008) <i>Der Nervenarzt</i> <i></i> <i></i> 79: 5 543-557<br/>

//publicationslist.org/tobias.nef/refid180 2014-03-31T06:46:54Z

The process of developing a successful stroke rehabilitation methodology requires four key components: a good understanding of the pathophysiological mechanisms underlying this brain disease, clear neuroscientific hypotheses to guide therapy, adequate clinical assessments of its efficacy on multiple timescales, and a systematic approach to the application of modern technologies to assist in the ev...<br/><br/>E M Siekierka, K Eng, C Bassetti, A Blickenstorfer, M S Cameirao, V Dietz, A Duff, F Erol, T Ettlin, D M Hermann, T Keller, B Keisker, J Kesselring, R Kleiser, S Kollias, J P Kool, A Kurre, S Mangold, T Nef, P Pyk, R Riener, C Schuster, F Tosi, P F M J Verschure, L Zimmerli (2007) <i>Neuro-degenerative diseases</i> <i></i> <i></i> 4: 1 57-69<br/>

//publicationslist.org/tobias.nef/refid179 2014-03-31T06:46:54Z

Task-oriented, repetitive and intensive arm training can enhance arm rehabilitation in patients with paralyzed upper extremities due to lesions of the central nervous system. There is evidence that the training duration is a key factor for the therapy progress. Robot-supported therapy can improve the rehabilitation allowing more intensive training. This paper presents the kinematics, the control a...<br/><br/>Tobias Nef, Matjaz Mihelj, Robert Riener (2007) <i>Medical & biological engineering & computing</i> <i></i> <i></i> 45: 9 887-900<br/>

//publicationslist.org/tobias.nef/refid199 2014-05-09T11:13:56Z

Predicting the behavior of phobic patients in a confrontational situation is challenging. While avoidance as a major clinical component of phobias suggests that patients orient away from threat, findings based on cognitive paradigms indicate an attentional bias towards threat. Here we present eye movement data from 21 spider phobics and 21 control subjects, based on 3 basic oculomotor tasks and a ...<br/><br/>Tobias Pflugshaupt, Urs P Mosimann, Wolfgang J Schmitt, Roman von Wartburg, Pascal Wurtz, Mathias Lüthi, Thomas Nyffeler, Christian W Hess, René M Müri (2007) <i>Journal of anxiety disorders</i> <i></i> <i></i> 21: 3 353-366<br/>

//publicationslist.org/tobias.nef/refid334 2014-05-23T12:05:26Z

Nyffeler T, Müri RM (2007) <i>Das TMS Buch</i> 411-419<br/>

//publicationslist.org/tobias.nef/refid257 2014-05-09T11:16:02Z

The combination of acquired mirror writing and reading is an extremely rare neurological disorder. It is encountered when brain damaged patients prefer horizontally mirrored over normal script in writing and reading. Previous theories have related this pathology to a disinhibition of mirrored engrams in the non-dominant hemisphere, possibly accompanied by a reversal of the preferred scanning direc...<br/><br/>Tobias Pflugshaupt, Thomas Nyffeler, Roman von Wartburg, Pascal Wurtz, Mathias Lüthi, Daniela Hubl, Klemens Gutbrod, Freimut D Juengling, Christian W Hess, René M Müri (2007) <i>Neuropsychologia</i> <i></i> <i></i> 45: 9 2078-2091<br/>

//publicationslist.org/tobias.nef/refid255 2014-05-09T11:16:02Z

Daniela Hubl, Martinus Hauf, Claudia van Swam, René Müri, Thomas Dierks, Werner Strik (2007) <i>Lancet</i> <i></i> <i></i> 370: 9586 <br/>

//publicationslist.org/tobias.nef/refid254 2014-05-09T11:16:02Z

In the anti-saccade paradigm, subjects are instructed not to make a reflexive saccade to an appearing lateral target but to make an intentional saccade to the opposite side instead. The inhibition of reflexive saccade triggering is under the control of the dorsolateral prefrontal cortex (DLPFC). The critical time interval at which this inhibition takes place during the paradigm, however, is not ex...<br/><br/>Thomas Nyffeler, René M Müri, Y Bucher-Ottiger, Charles Pierrot-Deseilligny, Bertrand Gaymard, Sophie Rivaud-Pechoux (2007) <i>The European journal of neuroscience</i> <i></i> <i></i> 26: 5 1381-1385<br/>

//publicationslist.org/tobias.nef/refid253 2014-05-09T11:16:02Z

The cardinal feature of spatial neglect is severely impaired exploration of the contralesional space, a failure resulting in unawareness of many contralesional stimuli. This deficit is exacerbated by a reflexive attentional bias toward ipsilesional items. Here we show that, in addition to these spatially lateralized failures, neglect patients also exhibit a severe bias favouring stimuli presented ...<br/><br/>Radek Ptak, Armin Schnider, Laetitia Golay, René Müri (2007) <i>Brain : a journal of neurology</i> <i></i> <i></i> 130: Pt 12 3211-3222<br/>

//publicationslist.org/tobias.nef/refid256 2014-05-09T11:16:02Z

We investigated the effect of image size on saccade amplitudes. First, in a meta-analysis, relevant results from previous scene perception studies are summarised, suggesting the possibility of a linear relationship between mean saccade amplitude and image size. Forty-eight observers viewed 96 colour scene images scaled to four different sizes, while their eye movements were recorded. Mean and medi...<br/><br/>Roman von Wartburg, Pascal Wurtz, Tobias Pflugshaupt, Thomas Nyffeler, Mathias Lüthi, René M Müri (2007) <i>Perception</i> <i></i> <i></i> 36: 3 355-365<br/>

//publicationslist.org/tobias.nef/refid201 2014-05-09T11:13:56Z

Transcranial magnetic stimulation has evolved into a powerful neuroscientific tool allowing to interfere transiently with specific brain functions. In addition, repetitive TMS (rTMS) has long-term effects (e.g. on mood), probably mediated by neurochemical alterations. While long-term safety of rTMS with regard to cognitive functioning is well established from trials exploring its therapeutic effic...<br/><br/>Michael Wagner, Tonia A Rihs, Urs P Mosimann, Hans U Fisch, Thomas E Schlaepfer (2006) <i>Journal of psychiatric research</i> <i></i> <i></i> 40: 4 315-321<br/>

//publicationslist.org/tobias.nef/refid200 2014-05-09T11:13:56Z

Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) have overlapping clinical and pathologic features. Recurrent visual hallucinations (RVH) are common in both disorders. The authors have compared details of hallucination characteristics and associated neuropsychiatric features in DLB and PDD.<br/><br/>Urs P Mosimann, Elise N Rowan, Cassie E Partington, Daniel Collerton, Elizabeth Littlewood, John T O'Brien, David J Burn, Ian G McKeith (2006) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 14: 2 153-160<br/>

//publicationslist.org/tobias.nef/refid197 2014-05-09T11:13:56Z

There is little data on stopping cholinesterase inhibitors in Dementia with Lewy bodies (DLB). Equally, it is not known if increasing the dose of cholinesterase inhibitors may help neuropsychiatric symptoms in advanced DLB.<br/><br/>Sanjeet Pakrasi, Alan Thomas, Urs P Mosimann, David A Cousins, Debbie Lett, David J Burn, John T O'Brien, Ian G McKeith (2006) <i>International journal of geriatric psychiatry</i> <i></i> <i></i> 21: 8 719-721<br/>

//publicationslist.org/tobias.nef/refid196 2014-05-09T11:13:56Z

Orthostatic hypotension is common in Lewy body disorders and may be related to disease progression and the spread of Lewy body pathology. We therefore hypothesize that PD patients with orthostatic hypotension (OH) have a different cognitive profile compared to PD patients without OH.<br/><br/>Liesl M Allcock, Rose Anne Kenny, Urs Peter Mosimann, Sherley Tordoff, Keith A Wesnes, Anthony J Hildreth, David J Burn (2006) <i>International journal of geriatric psychiatry</i> <i></i> <i></i> 21: 8 778-783<br/>

//publicationslist.org/tobias.nef/refid262 2014-05-09T11:16:02Z

Repetitive transcranial magnetic stimulation (rTMS) is a means to study the function and connectivity of brain areas. The present study addressed the question of hemispheric asymmetry of frontal regions and aimed to further understand the acute effects of high- and low-frequency rTMS on regional cerebral blood flow (rCBF). Sixteen healthy right-handed men were imaged using H(2)(15)O positron emiss...<br/><br/>D Knoch, V Treyer, M Regard, R M Müri, A Buck, B Weber (2006) <i>NeuroImage</i> <i></i> <i></i> 31: 2 641-648<br/>

//publicationslist.org/tobias.nef/refid260 2014-05-09T11:16:02Z

Recovery from eye movement deficits after cortical lesions is amazingly rapid and almost complete, which is in sharp contrast to most other neurological deficits of cerebral lesions. The underlying mechanisms of this successful recovery remain uncertain. We had the rare opportunity to examine two patients with recovery from saccade deficits after a lesion restricted to the frontal eye field (FEF) ...<br/><br/>Thomas Nyffeler, René Müri, Tobias Pflugshaupt, Roman Wartburg, Christian W Hess (2006) <i>The European journal of neuroscience</i> <i></i> <i></i> 23: 5 1397-1402<br/>

//publicationslist.org/tobias.nef/refid259 2014-05-09T11:16:02Z

The aim of the study was to compare the effect duration of two different protocols of repetitive transcranial magnetic stimulation (rTMS) on saccade triggering. In four experiments, two regions (right frontal eye field (FEF) and vertex) were stimulated using a 1-Hz and a theta burst protocol (three 30Hz pulses repeated at intervals of 100ms). The same number of TMS pulses (600 pulses) was applied ...<br/><br/>Thomas Nyffeler, Pascal Wurtz, Hans-Rudolf Lüscher, Christian W Hess, Walter Senn, Tobias Pflugshaupt, Roman von Wartburg, Mathias Lüthi, René M Müri (2006) <i>Neuroscience letters</i> <i></i> <i></i> 409: 1 57-60<br/>

//publicationslist.org/tobias.nef/refid258 2014-05-09T11:16:02Z

The ability of the brain to adjust to changing environments and to recover from damage rests on its remarkable capacity to adapt through plastic changes of underlying neural networks. We show here with an eye movement paradigm that a lifetime of plastic changes can be extended to several hours by repeated applications of theta burst transcranial magnetic stimulation to the frontal eye field of the...<br/><br/>Thomas Nyffeler, Pascal Wurtz, Hans-Rudolf Lüscher, Christian W Hess, Walter Senn, Tobias Pflugshaupt, Roman von Wartburg, Mathias Lüthi, René M Müri (2006) <i>The European journal of neuroscience</i> <i></i> <i></i> 24: 10 2961-2966<br/>

//publicationslist.org/tobias.nef/refid261 2014-05-09T11:16:02Z

Previous work has reported that in the Iowa gambling task (IGT) advantageous decisions may be taken before the advantageous strategy is known [Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997). Deciding advantageously before knowing the advantageous strategy. Science, 275, 1293-1295]. In order to test whether explicit memory is essential for the acquisition of a behavioural preference ...<br/><br/>Klemens Gutbrod, Claudine Krouzel, Helene Hofer, René Müri, Walter Perrig, Radek Ptak (2006) <i>Neuropsychologia</i> <i></i> <i></i> 44: 8 1315-1324<br/>

//publicationslist.org/tobias.nef/refid198 2014-05-09T11:13:56Z

The objective of this study was to compare functional impairments in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) and their relationship with motor and neuropsychiatric symptoms.<br/><br/>Ian G McKeith, Elise Rowan, Kristina Askew, Anitha Naidu, Louise Allan, Nicky Barnett, Debbie Lett, Urs P Mosimann, David Burn, John T O'Brien (2006) <i>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</i> <i></i> <i></i> 14: 7 582-588<br/>

//publicationslist.org/tobias.nef/refid264 2014-05-09T11:16:02Z

This chapter reviews the anatomical correlations of the cortical oculomotor centers in humans. The modern structural methods allow a better anatomical definition of the parietal, frontal and temporal structures involved in oculomotor control. Functional imaging reveals the cortical networks involved in saccadic, pursuit, and vestibular eye movements. Finally, the interaction of the network between...<br/><br/>René M Müri (2006) <i>Progress in brain research</i> <i></i> <i></i> 151: 503-526<br/>

//publicationslist.org/tobias.nef/refid263 2014-05-09T11:16:02Z

The aim of the study was to examine the effect of low-frequency repetitive transcranial magnetic stimulation on saccade triggering. In five participants, a train of 600 pulses with a frequency of 1 Hz was applied over the right frontal eye field and--as control condition--over the vertex. After repetitive transcranial magnetic stimulation application, oculomotor performance was evaluated with an o...<br/><br/>Thomas Nyffeler, Pascal Wurtz, Tobias Pflugshaupt, Roman von Wartburg, Mathias Luthi, Christian W Hess, René M Muri (2006) <i>Neuroreport</i> <i></i> <i></i> 17: 3 273-275<br/>

//publicationslist.org/tobias.nef/refid203 2014-05-09T11:13:56Z

Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age-...<br/><br/>Urs P Mosimann, René M Müri, David J Burn, Jacques Felblinger, John T O'Brien, Ian G McKeith (2005) <i>Brain : a journal of neurology</i> <i></i> <i></i> 128: Pt 6 1267-1276<br/>

//publicationslist.org/tobias.nef/refid202 2014-05-09T11:13:56Z

Fluctuations in consciousness and visual hallucinations are common neuropsychiatric features of dementia with Lewy bodies and Parkinson's disease dementia. To investigate potential neural correlates, we compared how changes in brain perfusion over a 1-year period were related to changes in the severity of these key clinical features. We recruited 29 subjects with either Parkinson's disease with de...<br/><br/>John T O'Brien, Michael J Firbank, Urs P Mosimann, David J Burn, Ian G McKeith (2005) <i>Psychiatry research</i> <i></i> <i></i> 139: 2 79-88<br/>

//publicationslist.org/tobias.nef/refid336 2014-05-23T12:19:25Z

Müri,RM, Hess, CW, Pierrot-Deseilligny, C. (2005) <i>Magnetic stimulation in clinical Neurophysiology</i> 349-364<br/>

//publicationslist.org/tobias.nef/refid206 2014-05-09T11:13:56Z

Cognitive-motivational theories of phobias propose that patients' behavior is characterized by a hypervigilance-avoidance pattern. This implies that phobics initially direct their attention towards fear-relevant stimuli, followed by avoidance that is thought to prevent objective evaluation and habituation. However, previous experiments with highly anxious individuals confirmed initial hypervigilan...<br/><br/>Tobias Pflugshaupt, Urs P Mosimann, Roman von Wartburg, Wolfgang Schmitt, Thomas Nyffeler, René M Müri (2005) <i>Journal of anxiety disorders</i> <i></i> <i></i> 19: 1 105-116<br/>

//publicationslist.org/tobias.nef/refid326 2014-05-23T10:26:38Z

Jost, T Ouerhani, N, von Wartburg, R, Müri, RM, Hügli, H (2005) <i>Computer Vision and Image Understanding Journal (CVIU) (2004)</i> : <br/>

//publicationslist.org/tobias.nef/refid325 2014-05-23T10:04:59Z

Jost, T, Ouerhani, N, von Warturg, R, Müri, RM, Hügli, H. (2005) <i>Computer Vision and Image Understanding</i> 100: 107-123<br/>

//publicationslist.org/tobias.nef/refid272 2014-05-09T11:16:02Z

We describe a patient with a topographical disorientation after a stroke of the right mediotemporooccipital lobe including the parahippocampal cortex (PHC). Clinical observations and neuropsychological testing reveal an impairment of allocentric spatial representations as well as impairments of visuospatial learning and memory. These findings are in accordance with the well-known function of the P...<br/><br/>Thomas Nyffeler, Klemens Gutbrod, Tobias Pflugshaupt, Roman von Wartburg, Christian W Hess, René M Müri (2005) <i>Cortex; a journal devoted to the study of the nervous system and behavior</i> <i></i> <i></i> 41: 2 133-143<br/>

//publicationslist.org/tobias.nef/refid271 2014-05-09T11:16:02Z

The dorsolateral prefrontal cortex (DLPFC) is involved in the preparation of saccadic eye movements. Lesion studies and functional magnetic resonance imaging (fMRI) studies suggest that the human DLPFC is located in area 46 of Brodmann. The DLPFC has direct connections with the main cortical ocular motor areas, that is with the frontal eye field (FEF) and the supplementary eye field (SEF) in the f...<br/><br/>Ch Pierrot-Deseilligny, R M Müri, T Nyffeler, D Milea (2005) <i>Annals of the New York Academy of Sciences</i> <i></i> <i></i> 1039: 239-251<br/>

//publicationslist.org/tobias.nef/refid181 2014-03-31T06:46:54Z

Task-oriented repetitive movements can improve muscle strength and movement co-ordination in patients with impairments due to neurological lesions. The application of robotics and automation technology can serve to assist, enhance, evaluate and document the rehabilitation of movements. The paper provides an overview of existing devices that can support movement therapy of the upper extremities in ...<br/><br/>R Riener, T Nef, G Colombo (2005) <i>Medical & biological engineering & computing</i> <i></i> <i></i> 43: 1 2-10<br/>

//publicationslist.org/tobias.nef/refid267 2014-05-09T11:16:02Z

In general, intermittent diplopia evokes suspicion of ocular myasthenia gravis. However, other etiologies such as Brown syndrome or myokymia of the superior oblique may provoke intermittent diplopia. We present a case of intermittent diplopia due to a tumor in the cavernous sinus. A 59-year-old patient reported intermittent diplopia after prolonged downward gaze to the right. All other gaze direct...<br/><br/>R M Müri, E Klimmeck, P Imesch (2005) <i>Revue neurologique</i> <i></i> <i></i> 161: 5 575-577<br/>

//publicationslist.org/tobias.nef/refid269 2014-05-09T11:16:02Z

The present study investigated the role of the right posterior parietal cortex (PPC) in the triggering of memory-guided saccades by means of double-pulse transcranial magnetic stimulation (dTMS). Shortly before saccade onset, dTMS with different interstimulus intervals (ISI; 35, 50, 65 or 80 ms) was applied. For contralateral saccades, dTMS significantly decreased saccadic latency with an ISI of 8...<br/><br/>Thomas Nyffeler, Andreas Egli, Tobias Pflugshaupt, Roman von Wartburg, Pascal Wurtz, Urs Mosimann, Christian W Hess, René M Müri (2005) <i>The European journal of neuroscience</i> <i></i> <i></i> 22: 2 535-538<br/>

//publicationslist.org/tobias.nef/refid270 2014-05-09T11:16:02Z

The aim of the present single case study was to investigate oculomotor recovery in a patient with simultanagnosia due to biparietal hypoxic lesions. Applying visual exploration as well as basic oculomotor tasks in three consecutive test sessions--i.e. 8 weeks, 14 weeks, and 37 weeks after brain damage had occurred--differential recovery was observed. While visual exploration remarkably improved, a...<br/><br/>Thomas Nyffeler, Tobias Pflugshaupt, Helene Hofer, Uli Baas, Klemens Gutbrod, Roman von Wartburg, Christian W Hess, René M Müri (2005) <i>Neuropsychologia</i> <i></i> <i></i> 43: 11 1591-1597<br/>

//publicationslist.org/tobias.nef/refid265 2014-05-23T10:02:11Z

The aim of this study was to investigate how oculomotor behaviour depends on the availability of colour information in pictorial stimuli. Forty study participants viewed complex images in colour or grey-scale, while their eye movements were recorded. We found two major effects of colour. First, although colour increases the complexity of an image, fixations on colour images were shorter than on th...<br/><br/>Roman von Wartburg, Nabil Ouerhani, Tobias Pflugshaupt, Thomas Nyffeler, Pascal Wurtz, Heinz Hügli, René M Müri (2005) <i>Neuroreport</i> <i></i> <i></i> 16: 14 1557-1560<br/>

//publicationslist.org/tobias.nef/refid266 2014-05-09T11:16:02Z

Visual disturbances are common after severe head trauma. Some authors report 50 percent of these patients having damage to the visual system, ocular motor nerve palsies, or central eye movement disturbances. Visual disturbances influence prognosis and outcome of neurological rehabilitation, and, in most cases, diagnosis and treatment require interdisciplinary care.<br/><br/>R M Müri, E Klimmeck, P Imesch (2005) <i>Revue neurologique</i> <i></i> <i></i> 161: 5 602-604<br/>

//publicationslist.org/tobias.nef/refid268 2014-05-09T11:16:02Z

The term visual field corresponds to the angular field of view that is seen by the eyes when they are fixed on a point straight-ahead. In neurological patients--e.g. stroke, trauma, or tumour patients--visual field function can be restricted, depending on lesion site and size. In contrast, the term "functional visual field" describes the area of visual field responsiveness under more ordinary view...<br/><br/>R M Müri, T Pflugshaupt, T Nyffeler, R von Wartburg, P Wurtz (2005) <i>Revue neurologique</i> <i></i> <i></i> 161: 5 513-517<br/>

//publicationslist.org/tobias.nef/refid275 2014-05-09T11:16:02Z

The performance of memory-guided saccades with two different delays (3 s and 30 s of memorisation) was studied in eight subjects. Single pulse transcranial magnetic stimulation (TMS) was applied simultaneously over the left and right dorsolateral prefrontal cortex (DLPFC) 1 s after target presentation. In both delays, stimulation significantly increased the percentage of error in amplitude of memo...<br/><br/>Thomas Nyffeler, Charles Pierrot-Deseilligny, Tobias Pflugshaupt, Roman von Wartburg, Christian W Hess, René M Müri (2004) <i>Experimental brain research</i> <i></i> <i></i> 154: 1 109-112<br/>

//publicationslist.org/tobias.nef/refid274 2014-05-09T11:16:02Z

This review focuses on eye movement control by the cerebral cortex, mainly in humans. Data have emerged based on the important contribution of recent techniques such as transcranial magnetic stimulation and functional magnetic resonance imaging, which provide complementary results to those of the classical lesion and electrical stimulation studies.<br/><br/>Charles Pierrot-Deseilligny, Dan Milea, René M Müri (2004) <i>Current opinion in neurology</i> <i></i> <i></i> 17: 1 17-25<br/>

//publicationslist.org/tobias.nef/refid207 2014-05-09T11:13:56Z

This article reviews the cholinergic changes in Parkinson's disease and dementia (PDD) and dementia with Lewy bodies (DLB), their potential clinical implications, and the available evidence for cholinesterase inhibitors in the treatment of PDD and DLB. Marked neuronal loss of cholinergic nuclei, reduced cholinergic markers in the neocortex, hippocampus, and selected thalamic nuclei, and receptor c...<br/><br/>Dag Aarsland, Urs P Mosimann, Ian G McKeith (2004) <i>Journal of geriatric psychiatry and neurology</i> <i></i> <i></i> 17: 3 164-171<br/>

//publicationslist.org/tobias.nef/refid204 2014-05-09T11:13:56Z

To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD).<br/><br/>U P Mosimann, G Mather, K A Wesnes, J T O'Brien, D J Burn, I G McKeith (2004) <i>Neurology</i> <i></i> <i></i> 63: 11 2091-2096<br/>

//publicationslist.org/tobias.nef/refid208 2014-05-09T11:13:56Z

Several studies on hemineglect have reported that patients recover remarkably well when assessed with neuropsychological screening tests, however, they show deficits on novel or complex tasks. We investigated whether such deficits can be revealed with eye movement analysis, applying two basic oculomotor tasks as well as two exploratory tasks. Eye movements were recorded in eight hemineglect patien...<br/><br/>Tobias Pflugshaupt, Stefanie Almoslöchner Bopp, Dörthe Heinemann, Urs P Mosimann, Roman von Wartburg, Thomas Nyffeler, Christian W Hess, René M Müri (2004) <i>Neuropsychologia</i> <i></i> <i></i> 42: 9 1203-1211<br/>

//publicationslist.org/tobias.nef/refid205 2014-05-09T11:13:56Z

Few studies have addressed the interaction between instruction content and saccadic eye movement control. To assess the impact of instructions on top-down control, we instructed 20 healthy volunteers to deliberately delay saccade triggering, to make inaccurate saccades or to redirect saccades--i.e. to glimpse towards and then immediately opposite to the target. Regular pro- and antisaccade tasks w...<br/><br/>U P Mosimann, J Felblinger, S J Colloby, R M Müri (2004) <i>Experimental brain research</i> <i></i> <i></i> 159: 2 263-267<br/>

//publicationslist.org/tobias.nef/refid211 2014-05-09T11:13:56Z

Eye movement behaviour during visual exploration of 24 patients with probable Alzheimer's disease and 24 age-matched controls was compared in a clock reading task. Controls were found to focus exploration on distinct areas at the end of each clock hand. The sum of these two areas of highest fixation density was defined as the informative region of interest (ROI). In Alzheimer's disease patients, v...<br/><br/>U P Mosimann, J Felblinger, P Ballinari, C W Hess, R M Müri (2004) <i>Brain : a journal of neurology</i> <i></i> <i></i> 127: Pt 2 431-438<br/>

//publicationslist.org/tobias.nef/refid273 2014-05-09T11:16:02Z

The aim of this study was to investigate the effect of single-pulse transcranial magnetic stimulation on the triggering of saccades. The right frontal eye field was stimulated during modified gap and overlap paradigms with flashed presentation of the lateral visual target of 80 ms. In order to examine possible facilitating or inhibitory effects on saccade triggering, three different time intervals...<br/><br/>Thomas Nyffeler, Oliver Bucher, Tobias Pflugshaupt, Roman Von Wartburg, Pascal Wurtz, Christian W Hess, René M Müri (2004) <i>The European journal of neuroscience</i> <i></i> <i></i> 20: 8 2240-2244<br/>

//publicationslist.org/tobias.nef/refid209 2014-05-09T11:13:56Z

Repetitive transcranial magnetic stimulation (rTMS) is a recent putative treatment for affective disorders. Several studies have demonstrated antidepressant effects of rTMS in younger patients; we aimed to assess its effect in older outpatients with treatment-resistant major depression. Twenty-four outpatients (mean age=62 years, S.D.=12) with major depression were randomized for sham or real stim...<br/><br/>Urs P Mosimann, Wolfgang Schmitt, Benjamin D Greenberg, Markus Kosel, René M Müri, Magdalena Berkhoff, Christian W Hess, Hans U Fisch, Thomas E Schlaepfer (2004) <i>Psychiatry research</i> <i></i> <i></i> 126: 2 123-133<br/>

//publicationslist.org/tobias.nef/refid210 2014-05-09T11:13:56Z

Lewy bodies (LB) in the central nervous system are associated with several different clinical syndromes including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Long term follow up of PD patients finds up to 78% eventually develop dementia, most of these patients exhibiting fluctuating cognition and visual hallucinations similar to DLB and with extensive cortical LB at autopsy. alph...<br/><br/>I G McKeith, U P Mosimann (2004) <i>Parkinsonism & related disorders</i> <i></i> <i></i> 10 Suppl 1: S15-S18<br/>

//publicationslist.org/tobias.nef/refid327 2014-05-23T10:09:13Z

Ouerhani, N, von Wartburg, R, Hügli, H, Müri RM. (2004) <i>Electronic Letters on Computer Vision and Image Analysis </i> 3: 13-24<br/>

//publicationslist.org/tobias.nef/refid341 2014-05-23T12:26:57Z

Straumann D, Müri RM, Hess K (2003) <i>Kompendium der Neurologie (2002)</i> 355-372<br/>

//publicationslist.org/tobias.nef/refid342 2014-05-23T12:29:11Z

Pierrot-Deseilligny, Müri RM, Ploner CJ, Gaymard B, Rivaud-Péchoux S. (2003) <i>Neural Control of Space Coding and Action Production </i> <br/>

//publicationslist.org/tobias.nef/refid340 2014-05-23T12:25:44Z

Müri RM (2003) <i>Kompendium der Neurologie (2002)</i> 373- 388<br/>

//publicationslist.org/tobias.nef/refid337 2014-05-23T12:21:36Z

Straumann D, Müri RM (2003) <i>Compendium de Neurologie</i> 351-361<br/>

//publicationslist.org/tobias.nef/refid338 2014-05-23T12:23:05Z

Müri RM (2003) <i>Compendium de Neurologie</i> 337-350<br/>

//publicationslist.org/tobias.nef/refid339 2014-05-23T12:24:22Z

Straumann D, Müri RM, Hess K. (2003) <i>Compendium de Neurologie</i> 321-336<br/>

//publicationslist.org/tobias.nef/refid278 2014-05-09T11:16:02Z

Three patients with a unilateral cortical lesion affecting the dorsolateral prefrontal cortex (DLPFC), i.e. Brodmann area 46, were tested using different paradigms of reflexive saccades (gap and overlap tasks), intentional saccades (antisaccades, memory-guided and predictive saccades) and smooth pursuit movements. Visually guided saccades with gap and overlap, latency of correct antisaccades and m...<br/><br/>C Pierrot-Deseilligny, R M Müri, C J Ploner, B Gaymard, S Demeret, S Rivaud-Pechoux (2003) <i>Brain : a journal of neurology</i> <i></i> <i></i> 126: Pt 6 1460-1473<br/>

//publicationslist.org/tobias.nef/refid279 2014-05-09T11:16:02Z

Our knowledge of the cortical control of saccadic eye movements (saccades) in humans has recently progressed mainly thanks to lesion and transcranial magnetic stimulation (TMS) studies, but also to functional imaging. It is now well-known that the frontal eye field is involved in the triggering of intentional saccades, the parietal eye field in that of reflexive saccades, the supplementary eye fie...<br/><br/>C Pierrot-Deseilligny, R M Müri, C J Ploner, B Gaymard, S Rivaud-Péchoux (2003) <i>Progress in brain research</i> <i></i> <i></i> 142: 3-17<br/>

//publicationslist.org/tobias.nef/refid276 2014-05-23T10:13:35Z

To study the influence of cycloversions induced by head tilt on parameters of scanning laser polarimetry.<br/><br/>Andrea B Jehn, René M Muri, Daniel S Mojon (2003) <i>Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde</i> <i></i> <i></i> 217: 5 311-314<br/>

//publicationslist.org/tobias.nef/refid212 2014-05-09T11:13:56Z

Dementia with Lewy bodies (DLB) accounts for 15-20% of all autopsy confirmed dementias in old age. Characteristic histopathological changes are intracellular Lewy bodies and Lewy neurites, with abundant senile plaques but sparse neurofibrillary tangles. Core clinical features are fluctuating cognitive impairment, persistent visual hallucinations and extrapyramidal motor symptoms (parkinsonism). On...<br/><br/>U P Mosimann, I G McKeith (2003) <i>Swiss medical weekly</i> <i></i> <i></i> 133: 9-10 131-142<br/>

//publicationslist.org/tobias.nef/refid280 2014-05-09T11:16:02Z

The prefrontal cortex (PFC) is known to inhibit unwanted saccades through its connections to the superior colliculus (SC). Indeed, transcranial magnetic stimulation (TMS) of the PFC decreases saccade latency by increasing the rate of express saccades. This study examined whether a similar phenomenon exists for vergence.<br/><br/>Olivier Coubard, Zoï Kapoula, René Müri, Sophie Rivaud-Péchoux (2003) <i>Investigative ophthalmology & visual science</i> <i></i> <i></i> 44: 2 600-609<br/>

//publicationslist.org/tobias.nef/refid277 2014-05-09T11:16:02Z

Fifteen healthy volunteers performed a memory-pointing task using their right arm while single-pulse transcranial magnetic stimulation (TMS) above motor threshold was applied over the posterior parietal or prefrontal cortex of the left or right hemisphere in four blocks of trials. The stimulation was randomly delivered at one of three time intervals during the 3-s delay period (early: 300 ms, inte...<br/><br/>Nikolaos Smyrnis, Christos Theleritis, Ioannis Evdokimidis, Rene M Müri, Nikos Karandreas (2003) <i>Journal of neurophysiology</i> <i></i> <i></i> 89: 6 3344-3350<br/>

//publicationslist.org/tobias.nef/refid213 2014-05-09T11:13:56Z

The performance of memory-guided saccades with two different delays (3 and 30 s of memorization) was studied in seven healthy subjects. Double-pulse transcranial magnetic stimulation (dTMS) with an interstimulus interval of 100 ms was applied over the right dorsolateral prefrontal cortex (DLPFC) early (1 s after target presentation) and late (28 s after target presentation). Early stimulation sign...<br/><br/>Thomas Nyffeler, Charles Pierrot-Deseilligny, Jaques Felblinger, Urs P Mosimann, Christian W Hess, René M Müri (2002) <i>The European journal of neuroscience</i> <i></i> <i></i> 16: 9 1823-1827<br/>

//publicationslist.org/tobias.nef/refid284 2014-05-20T08:03:27Z

The neural mechanisms underlying the craniotopic updating of visual space across saccadic eye movements are poorly understood. Previous single-unit recording studies in primates and clinical studies in brain-damaged patients have shown that the posterior parietal cortex (PPC) has a key role in this process. In the present study, we used single-pulse transcranial magnetic stimulation (TMS) to disru...<br/><br/>Paul van Donkelaar, René Müri (2002) <i>Proceedings. Biological sciences / The Royal Society</i> <i></i> <i></i> 269: 1492 735-739<br/>

//publicationslist.org/tobias.nef/refid343 2014-05-23T12:38:31Z

Pierrot-Deseilligny C, Ploner CJ, Müri RM, Gaymard B, Rivaud-Péchoux S. (2002) <i>Annals of the New York Academy of Sciences 956:</i> 216-229<br/>

//publicationslist.org/tobias.nef/refid344 2014-05-23T12:40:59Z

Müri RM, Hess CW, Pierrot-Deseilligny C. (2002) <i> Handbook of Magnetic Stimulation</i> 313-322<br/>

//publicationslist.org/tobias.nef/refid214 2014-05-09T11:13:56Z

Urs P Mosimann, Susanne C Marré, Stefan Werlen, Wolfgang Schmitt, Christian W Hess, Hans U Fisch, Thomas E Schlaepfer (2002) <i>Archives of general psychiatry</i> <i></i> <i></i> 59: 6 560-561<br/>

//publicationslist.org/tobias.nef/refid215 2014-05-09T11:13:56Z

Transcranial magnetic stimulation (TMS) was used to study visuospatial attention processing in ten healthy volunteers. In a forced choice recognition task the subjects were confronted with two symbols simultaneously presented during 120 ms at random positions, one in the left and the other in the right visual field. The subject had to identify the presented pattern out of four possible combination...<br/><br/>R M Müri, R Bühler, D Heinemann, U P Mosimann, J Felblinger, T E Schlaepfer, C W Hess (2002) <i>Experimental brain research</i> <i></i> <i></i> 143: 4 426-430<br/>

//publicationslist.org/tobias.nef/refid281 2014-05-09T11:16:02Z

Focal chondral or osteochondral defects can be painful and disabling, have a poor capacity for repair, and may predispose patients for osteoarthritis. New surgical procedures that aim to reestablish hyaline cartilage have been introduced and the results seem promising. The purpose of this study is to provide reliable data on chondral and osteochondral defects in patients with symptomatic knees req...<br/><br/>Karin Hjelle, Eirik Solheim, Torbjørn Strand, Rune Muri, Mats Brittberg (2002) <i>Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association</i> <i></i> <i></i> 18: 7 730-734<br/>

//publicationslist.org/tobias.nef/refid283 2014-05-09T11:16:02Z

Our knowledge of the cortical control of saccadic eye movements (saccades) in humans has recently progressed mainly because of lesion and transcranial magnetic stimulation (TMS) studies, but also because of functional imaging. It is now well known that the frontal eye field is involved in the control of intentional saccades, the parietal eye field in that of reflexive saccades, the supplementary e...<br/><br/>Ch Pierrot-Deseilligny, C J Ploner, R M Muri, B Gaymard, S Rivaud-Pechoux (2002) <i>Annals of the New York Academy of Sciences</i> <i></i> <i></i> 956: 216-229<br/>

//publicationslist.org/tobias.nef/refid282 2014-05-09T11:16:02Z

We review current knowledge of the cortical control of spatial memory, studied using visuooculomotor paradigms. Spatial memory is an essential cognitive process that can be involved in preparing motor responses. Our knowledge of spatial memory in humans recently has progressed thanks to the use of ocular saccades as a convenient model of motor behavior. Accuracy of memory-guided saccades, made to ...<br/><br/>Charles Pierrot-Deseilligny, René M Müri, Sophie Rivaud-Pechoux, Bertrand Gaymard, Christoph J Ploner (2002) <i>Annals of neurology</i> <i></i> <i></i> 52: 1 10-19<br/>

//publicationslist.org/tobias.nef/refid285 2014-05-20T08:03:27Z

Transcranial magnetic stimulation (TMS) was applied over the frontal eye field (FEF) and the supplementary eye field (SEF) regions before execution of the first saccade in a double step task. When applied over the FEF, stimulation increased the percentage error in amplitude of the contralateral second saccade as compared to no stimulation. This was due to an interference with retinotopic but not c...<br/><br/>Philippe N Tobler, René M Müri (2002) <i>Neuroreport</i> <i></i> <i></i> 13: 2 253-255<br/>

//publicationslist.org/tobias.nef/refid286 2014-05-20T08:03:27Z

Previous studies showed that transcranial magnetic stimulation (TMS) of the posterior parietal cortex (PPC) prolongs the latency of intentional saccades. We examined whether a similar effect exists for reflexive saccades and vergence. To elicit reflexive movements, a gap paradigm was used; lateral saccades and vergence along the median plane were interleaved. TMS was applied on the right PPC 80 ms...<br/><br/>Z Kapoula, E Isotalo, R M Müri, M P Bucci, S Rivaud-Péchoux (2001) <i>Neuroreport</i> <i></i> <i></i> 12: 18 4041-4046<br/>

//publicationslist.org/tobias.nef/refid287 2014-05-20T08:03:27Z

In order to investigate the neuronal network involved in processing extraretinal signals, functional magnetic resonance imaging (fMRI) was applied to subjects performing the double step saccade paradigm. There, the calculation of the amplitude of the second saccade must rely on extraretinal signals of the first. When compared to a task where both saccades could be performed by means of retinal sig...<br/><br/>P N Tobler, J Felblinger, M Bürki, A C Nirkko, C Ozdoba, R M Müri (2001) <i>Vision research</i> <i></i> <i></i> 41: 10-11 1351-1358<br/>

//publicationslist.org/tobias.nef/refid217 2014-05-09T11:13:56Z

Repetitive transcranial magnetic stimulation (rTMS) is a novel research tool in neurology and psychiatry. It is currently being evaluated as a conceivable alternative to electroconvulsive therapy for the treatment of mood disorders. Eight healthy young (age range 21-25 years) right-handed men without sleep complaints participated in the study. Two sessions at a 1-week interval, each consisting of ...<br/><br/>T Graf, J Engeler, P Achermann, U P Mosimann, R Noss, H U Fisch, T E Schlaepfer (2001) <i>Psychiatry research</i> <i></i> <i></i> 107: 1 1-9<br/>

//publicationslist.org/tobias.nef/refid216 2014-05-09T11:13:56Z

The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided s...<br/><br/>M Wipfli, J Felblinger, U P Mosimann, C W Hess, T E Schlaepfer, R M Müri (2001) <i>The European journal of neuroscience</i> <i></i> <i></i> 14: 3 571-575<br/>

//publicationslist.org/tobias.nef/refid288 2014-05-20T08:03:27Z

To study the temporal organisation of memory-guided saccade control we used single-pulse transcranial magnetic stimulation (TMS) over the left posterior parietal (PPC) and prefrontal cortex (PFC) in eight healthy subjects. TMS was applied either following presentation of a visual target, i.e. 160, 260, and 360 ms after the flashed point, or during the period of memorisation, i.e. between 700 and 1...<br/><br/>R M Müri, B Gaymard, S Rivaud, A Vermersch, C W Hess, C Pierrot-Deseilligny (2000) <i>Neuropsychologia</i> <i></i> <i></i> 38: 8 1105-1111<br/>

//publicationslist.org/tobias.nef/refid289 2014-05-20T08:03:27Z

Phantom limbs are traditionally conceptualized as the phenomenal persistence of a body part after deafferentation. Previous clinical observations of subjects with phantoms of congenitally absent limbs are not compatible with this view, but, in the absence of experimental work, the neural basis of such "aplasic phantoms" has remained enigmatic. In this paper, we report a series of behavioral, imagi...<br/><br/>P Brugger, S S Kollias, R M Müri, G Crelier, M C Hepp-Reymond, M Regard (2000) <i>Proceedings of the National Academy of Sciences of the United States of America</i> <i></i> <i></i> 97: 11 6167-6172<br/>

//publicationslist.org/tobias.nef/refid219 2014-05-09T11:13:56Z

In order to analyse the possible basis of subjective complaints following whiplash injury, horizontal eye movements were examined in subjects with persistent complaints ('symptomatic group') and subjects who had completely recovered ('recovered group'). The results for the symptomatic and recovered groups were compared with those for age-matched, healthy volunteers (control group). A battery of di...<br/><br/>U P Mosimann, R M Müri, J Felblinger, B P Radanov (2000) <i>Brain : a journal of neurology</i> <i></i> <i></i> 123 ( Pt 4): 828-835<br/>

//publicationslist.org/tobias.nef/refid218 2014-05-09T11:13:56Z

This study investigated the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) of the left prefrontal cortex (LPFC) on mood in a sham-controlled crossover design. Twenty-five healthy male subjects received HF-rTMS of the LPFC in real and sham conditions. Forty trains (frequency 20 Hz, stimulation intensity 100% of individual motor threshold, train duration 2 s, intertr...<br/><br/>U P Mosimann, T A Rihs, J Engeler, H Fisch, T E Schlaepfer (2000) <i>Psychiatry research</i> <i></i> <i></i> 94: 3 251-256<br/>

//publicationslist.org/tobias.nef/refid290 2014-05-20T08:03:27Z

Two different drawer tasks were investigated with the aim of assessing the role of eye movements in well-coordinated hand movements. In an unimanual step-tracking task, which had a predictive and an unpredictive movement, a two-way repeated-measures ANOVA showed a significant effect of prediction on the onset of grip-force (GF) rate (300+/-39 ms for the predictive condition versus 394+/-53 ms for ...<br/><br/>R M Müri, P Kaluzny, A Nirkko, M Frosch, M Wiesendanger (1999) <i>Experimental brain research</i> <i></i> <i></i> 128: 1-2 200-204<br/>

//publicationslist.org/tobias.nef/refid291 2014-05-20T08:03:27Z

The aim of the study was to determine the thiamin status in HIV-positive patients.<br/><br/>R M Müri, J Von Overbeck, J Furrer, P E Ballmer (1999) <i>Clinical nutrition (Edinburgh, Scotland)</i> <i></i> <i></i> 18: 6 375-378<br/>

//publicationslist.org/tobias.nef/refid292 2014-05-20T08:03:27Z

Single pulse transcranial magnet stimulation (TMS) was applied in five subjects during a saccadic gap task, i.e. with a temporal gap of 200 ms between the extinguishing of the central fixation point and the appearance of the lateral target. In all subjects, a significant increase of contralateral express saccades was found when TMS was applied over the dorsolateral prefrontal cortex (DPFC) at the ...<br/><br/>R M Müri, S Rivaud, B Gaymard, C J Ploner, A I Vermersch, C W Hess, C Pierrot-Deseilligny (1999) <i>Neuropsychologia</i> <i></i> <i></i> 37: 2 199-206<br/>

//publicationslist.org/tobias.nef/refid345 2014-05-23T12:44:14Z

Müri RM, Nirkko AC, Ozdoba C, Tobler P, Heid O, Schroth G, Hess CW (1998) <i>Current Oculomotor Research: Physiological and Psychological Aspects. </i> 235-240<br/>

//publicationslist.org/tobias.nef/refid294 2014-05-20T08:03:27Z

The POEMS syndrome is a multisystem disorder characterised by polyneuropathy, organomegaly endocrinopathy, plasma cell dyscrasia and skin changes. Along with many further manifestations this rare syndrome may also include macroangiopathy and acute vascular obliteration. In the literature such vascular problems have received only little attention and most case reports refer to involvement of the co...<br/><br/>A Forster, R Müri (1998) <i>Schweizerische medizinische Wochenschrift</i> <i></i> <i></i> 128: 26 1059-1064<br/>

//publicationslist.org/tobias.nef/refid295 2014-05-20T08:03:27Z

The technical limitations of electroencephalography (EEG) and flashed visually-evoked potentials (VEP) recordings in the static magnetic field of the MR system were systematically studied. A main artifact occurring in the magnetic field was found to be correlated with the heart cycle and had amplitudes in the range of EEG and VEP signals. For VEP recordings, a substantial reduction of this effect ...<br/><br/>R M Müri, J Felblinger, K M Rösler, B Jung, C W Hess, C Boesch (1998) <i>Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine</i> <i></i> <i></i> 39: 1 18-22<br/>

//publicationslist.org/tobias.nef/refid293 2014-05-20T08:03:27Z

The cortical activation pattern of saccades and antisaccades (versus rest) in the frontal lobe was analysed using an echo planar imaging (EPI) technique in 10 healthy subjects. Statistical analysis of activity in the dorsolateral prefrontal cortex disclosed a significantly greater activation during antisaccades in this region than during saccades. On the other hand, activity in the frontal eye fie...<br/><br/>R M Müri, O Heid, A C Nirkko, C Ozdoba, J Felblinger, G Schroth, C W Hess (1998) <i>Journal of neurology, neurosurgery, and psychiatry</i> <i></i> <i></i> 65: 3 374-377<br/>

//publicationslist.org/tobias.nef/refid332 2014-05-23T11:41:24Z

Müri RM, Faller J, Rösler KM. (1997) <i>Neuro-ophthalmology</i> 18: 97-104<br/>

//publicationslist.org/tobias.nef/refid298 2014-05-20T08:03:27Z

Power-based transcranial color-coded duplex sonography is a new development for cerebrovascular imaging that is suited for detection of slow velocities. The purpose of this study was to evaluate the ability of this technique to detect cerebral sinuses and veins by means of the occipital window and to provide reference data.<br/><br/>R W Baumgartner, A C Nirkko, R M Müri, F Gönner (1997) <i>Stroke; a journal of cerebral circulation</i> <i></i> <i></i> 28: 7 1319-1323<br/>

//publicationslist.org/tobias.nef/refid297 2014-05-20T08:03:27Z

To determine the ability of transtemporal power- and frequency-based transcranial color-coded duplex sonography to aid in the assessment of cerebral veins and sinuses, as well as to provide reference data for flow direction and velocity.<br/><br/>R W Baumgartner, F Gönner, M Arnold, R M Müri (1997) <i>AJNR. American journal of neuroradiology</i> <i></i> <i></i> 18: 9 1771-1781<br/>

//publicationslist.org/tobias.nef/refid299 2014-05-20T08:03:27Z

Eye movement disturbances resulting from cerebral lesions are reviewed and the specific roles of the different ocular motor areas are summarized. Three cortical areas may trigger saccades: the frontal eye field (FEF), the supplementary eye field (SEF) and the parietal eye field (PEF). The FEF could be involved mainly in intentional visual exploration (intentional saccades), the PEF mainly in refle...<br/><br/>C Pierrot-Deseilligny, B Gaymard, R Müri, S Rivaud (1997) <i>Journal of neurology</i> <i></i> <i></i> 244: 2 65-70<br/>

//publicationslist.org/tobias.nef/refid347 2014-05-23T12:46:53Z

Baumgartner RW, Gönner F, Müri RM (1997) <i>New trends in cerebral hemodynamics and neurosonology</i> <br/>

//publicationslist.org/tobias.nef/refid346 2014-05-23T12:45:35Z

Pierrot-Deseilligny C, Müri RM (1997) <i>Parietal lobe contributions in 3D Space</i> <br/>

//publicationslist.org/tobias.nef/refid296 2014-05-20T08:03:27Z

Echo contrast agents have been shown to provide conclusive examinations in most patients with insufficient ultrasound penetration through the temporal bone. We investigated the diagnostic value of contrast-enhanced (CE) transcranial color-coded duplex sonography (TCCD) in patients with ischemic cerebrovascular disease and insufficient temporal windows and evaluated TCCD criteria that predict wheth...<br/><br/>R W Baumgartner, M Arnold, F Gönner, I Staikow, C Herrmann, A Rivoir, R M Müri (1997) <i>Stroke; a journal of cerebral circulation</i> <i></i> <i></i> 28: 12 2473-2478<br/>

//publicationslist.org/tobias.nef/refid348 2014-05-23T12:50:40Z

Hess CW, Mathis J, Rösler KM, Müri RM (1997) <i>Perspectives of Motor Behavior and its Neural Basis</i> <br/>

//publicationslist.org/tobias.nef/refid301 2014-05-20T08:03:27Z

A method for monitoring eye movements in humans during functional MRI is presented. It is based on the acquisition of electro-oculographic (EOG) signals near one eye. EOG potentials were amplified and converted into an optical signal just outside the head coil. An optical fiber was used for signal transmission from inside the magnet bore to the control room. The EOG sensor was tested during EPI se...<br/><br/>J Felblinger, R M Müri, C Ozdoba, G Schroth, C W Hess, C Boesch (1996) <i>Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine</i> <i></i> <i></i> 36: 3 410-414<br/>

//publicationslist.org/tobias.nef/refid302 2014-05-20T08:03:27Z

A patient with a complete unilateral conjugate gaze paralysis caused by a small lesion affecting the region of the right abducens nucleus, documented by magnetic resonance imaging, is reported. Eye movements were quantitatively evaluated using electro-oculography. A gaze-evoked nystagmus to the contralateral side and impairment of smooth pursuit and vestibular ocular reflex in the contralateral he...<br/><br/>R M Müri, J F Chermann, L Cohen, S Rivaud, C Pierrot-Deseilligny (1996) <i>Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society</i> <i></i> <i></i> 16: 3 191-195<br/>

//publicationslist.org/tobias.nef/refid304 2014-05-20T08:03:27Z

To determine the roles of the putamen and pallidum in ocular motor control.<br/><br/>A I Vermersch, R M Müri, S Rivaud, M Vidailhet, B Gaymard, Y Agid, C Pierrot-Deseilligny (1996) <i>Journal of neurology, neurosurgery, and psychiatry</i> <i></i> <i></i> 60: 2 179-184<br/>

//publicationslist.org/tobias.nef/refid300 2014-05-20T08:03:27Z

1. We used single-pulse transcranial magnetic stimulation (TMS) to explore the temporal organization of the cortical control of memory-guided saccades in eight humans. The posterior parietal cortex (PPC) or the dorsolateral prefrontal cortex (DPFC), which are both known to be involved in the control of such saccades, were stimulated on the right side at different time intervals after the presentat...<br/><br/>R M Müri, A I Vermersch, S Rivaud, B Gaymard, C Pierrot-Deseilligny (1996) <i>Journal of neurophysiology</i> <i></i> <i></i> 76: 3 2102-2106<br/>

//publicationslist.org/tobias.nef/refid303 2014-05-20T08:03:27Z

The frontal eye field and parietal eye field are known to be involved during visually guided saccades. As the location of the human parietal eye field is not yet well known, functional MRI was used during such a saccade task to better localise this field. Besides activity in visual areas of the occipital cortex, bilateral activity was seen in the precentral sulcus, corresponding to the frontal eye...<br/><br/>R M Müri, M T Iba-Zizen, C Derosier, E A Cabanis, C Pierrot-Deseilligny (1996) <i>Journal of neurology, neurosurgery, and psychiatry</i> <i></i> <i></i> 60: 4 445-448<br/>

//publicationslist.org/tobias.nef/refid306 2014-05-20T08:03:27Z

Transcranial magnetic stimulation (TMS) over the region of the supplementary motor area (SMA) was used to study the cortical control of sequences of memory-guided saccades. In ten healthy subjects, TMS was applied during (a) the target presentation (learning) phase, (b) the memorization phase, and (c) the execution phase of such saccade sequences. Stimulation during the presentation phase resulted...<br/><br/>R M Müri, S Rivaud, A I Vermersch, J M Léger, C Pierrot-Deseilligny (1995) <i>Experimental brain research</i> <i></i> <i></i> 104: 1 163-166<br/>

//publicationslist.org/tobias.nef/refid220 2014-05-09T11:13:56Z

Several patients with chronic critical limb ischemia show angiographically an isolated popliteal segment (IPS) and a single calf vessel (SCV) with no direct communication to the former. In this situation a bypass can be inserted from the common femoral artery to the IPS or to the SCV. The results of 73 bypass procedures--40 to an isolated popliteal segment and 33 to a single calf vessel for limb s...<br/><br/>U P Mosimann, P Stirnemann (1995) <i>VASA. Zeitschrift für Gefässkrankheiten</i> <i></i> <i></i> 24: 1 49-55<br/>

//publicationslist.org/tobias.nef/refid305 2014-05-20T08:03:27Z

A scheme for the cortical control of saccadic eye movements is proposed based partly on defects revealed by specific test paradigms in humans with discrete lesions. Three different cortical areas are capable of triggering saccades. The frontal eye field disengages fixation, and triggers intentional saccades to visible targets, to remembered target locations, or to the location where it is predicte...<br/><br/>C Pierrot-Deseilligny, S Rivaud, B Gaymard, R Müri, A I Vermersch (1995) <i>Annals of neurology</i> <i></i> <i></i> 37: 5 557-567<br/>

//publicationslist.org/tobias.nef/refid328 2014-05-23T10:17:16Z

Müri RM, Baumgartner R (1995) <i>Neuro-ophthalmology</i> 15: 161-163<br/>

//publicationslist.org/tobias.nef/refid349 2014-05-23T12:52:01Z

Müri RM, Meienberg, O (1995) <i>Stroke syndromes</i> <br/>

//publicationslist.org/tobias.nef/refid309 2014-05-20T08:03:27Z

Memorised sequences of saccades are cortically controlled by the supplementary motor area (SMA), as shown in animal experiments and in humans with isolated SMA lesions. We applied transcranial magnetic stimulation (TMS) in eight healthy subjects executing memorised sequences of saccades. Sequences of three targets were presented. Then, upon a go-signal, the subjects had to execute the appropriate ...<br/><br/>R M Müri, K M Rösler, C W Hess (1994) <i>Experimental brain research</i> <i></i> <i></i> 101: 3 521-524<br/>

//publicationslist.org/tobias.nef/refid310 2014-05-20T08:03:27Z

The role of the hippocampal formation in the control of memory-guided saccades is unclear. We tested two types of memory-guided saccades with short memorization delay in three patients with a lesion affecting the right medial temporal lobe and involving the hippocampal formation. In single memory-guided saccades, testing spatial working memory, the gain of the patient group did not differ from tha...<br/><br/>R M Müri, S Rivaud, S Timsit, P Cornu, C Pierrot-Deseilligny (1994) <i>Experimental brain research</i> <i></i> <i></i> 101: 1 165-168<br/>

//publicationslist.org/tobias.nef/refid308 2014-05-20T08:03:27Z

Eye movements were recorded electro-oculographically in three patients with a small ischemic lesion affecting the left frontal eye field (FEF) and in 12 control subjects. Reflexive visually guided saccades (gap and overlap tasks), antisaccades, predictive saccades, memory-guided saccades, smooth pursuit and optokinetic nystagmus (OKN) were studied in the three patients. Staircase saccades and doub...<br/><br/>S Rivaud, R M Müri, B Gaymard, A I Vermersch, C Pierrot-Deseilligny (1994) <i>Experimental brain research</i> <i></i> <i></i> 102: 1 110-120<br/>

//publicationslist.org/tobias.nef/refid307 2014-05-20T08:03:27Z

1. Depolarization-induced changes in the cytosolic free calcium concentration ([Ca2+]i) were examined in slice-cultured neurons of the deep cerebellar nuclei by combined intracellular and multisite fura-2 recording techniques. 2. Firing of tetrodotoxin (TTX)-sensitive action potentials induced by depolarizing current pulses caused large elevations in somatic as well as proximal dendritic [Ca2+]i. ...<br/><br/>R Muri, T Knöpfel (1994) <i>Journal of neurophysiology</i> <i></i> <i></i> 71: 1 420-428<br/>

//publicationslist.org/tobias.nef/refid311 2014-05-20T08:03:27Z

30 right-handed subjects were given a lateralized tachistoscopic lexical-decision task. Subjects' belief in extrasensory perception (ESP) was assessed with a single six-point scale; 16 subjects were designated as believers in ESP and 14 subjects as nonbelievers. Believers in ESP did not exhibit a hemispheric asymmetry for the task while nonbelievers exhibited the expected right visual-field/left-h...<br/><br/>P Brugger, A Gamma, R Muri, M Schäfer, K I Taylor (1993) <i>Perceptual and motor skills</i> <i></i> <i></i> 77: 3 Pt 2 1299-1308<br/>

//publicationslist.org/tobias.nef/refid350 2014-05-23T12:54:01Z

Meienberg O, Müri RM (1993) <i>Neurologie in Klinik und Praxis. </i> <br/>

//publicationslist.org/tobias.nef/refid312 2014-05-20T08:03:27Z

Vertigo consists of a variety of syndromes and can be due to many etiologies. One of these causes is migraine, which in our experience is often overlooked, although migrainous vertigo is well known in the literature. Vertigo in migraine can occur as aura or during the headache phase, or independent of the attacks as aura without headache. The aim of this retrospective study was to analyze cases wi...<br/><br/>R M Müri, O Meienberg (1993) <i>Schweizerische medizinische Wochenschrift</i> <i></i> <i></i> 123: 26 1331-1336<br/>

//publicationslist.org/tobias.nef/refid224 2014-05-23T10:19:24Z

Ocular vascular occlusive disease resulting in severe retinopathy and/or post-thrombotic glaucoma has been extensively discussed in patients with lupus anticoagulant and/or anticardiolipin antibodies (LA/aCL). Inadequate circulation plays an important role in the pathogenesis of another ophthalmic entity--the normal tension glaucoma. We studied 22 patients with normal tension glaucoma (group I) an...<br/><br/>D A Tsakiris, R Osusky, H J Kaiser, R Mueri, J Flammer, G A Marbet (1992) <i>Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis</i> <i></i> <i></i> 3: 5 541-545<br/>

//publicationslist.org/tobias.nef/refid313 2014-05-20T08:03:27Z

Lesions of the brain stem can either affect the nuclei or the fascicles of the third, fourth or sixth cranial nerves and thus produce ocular motor disorders. Lesions of the oculomotor nuclear complex differ from lesions of the third nerve, since the motoneurones in the nucleus are specifically grouped. Similarly, a lesion of the sixth nerve nucleus results in a conjugate gaze palsy and not in an a...<br/><br/>O Meienberg, R Müri (1992) <i>Baillière's clinical neurology</i> <i></i> <i></i> 1: 2 417-434<br/>

//publicationslist.org/tobias.nef/refid314 2014-05-20T08:03:27Z

Single transcranial magnetic pulsed stimuli were applied over the cortical area of the putative right frontal eye field (FEF) in 11 healthy subjects. An especially designed figure of eight shaped twin coil was used, to focus the stimulus, the strength of which was adjusted to the individual motor threshold of the left hand muscles. Eye positions and movements were recorded by an infrared reflectio...<br/><br/>R M Müri, C W Hess, O Meienberg (1991) <i>Experimental brain research</i> <i></i> <i></i> 86: 1 219-223<br/>

//publicationslist.org/tobias.nef/refid315 2014-05-20T08:03:27Z

39 cases with isolated trochlear nerve palsies of traumatic origin have been analyzed retrospectively. 18 patients (46%) had had cerebral contusion, 15 (39%) cerebral concussion, and 6 patients (15%) a minor head trauma. 33 patients had unilateral trochlear nerve palsies and 6 (all of them with cerebral contusion) bilateral. The degree of the palsies did not correlate with the severity of the head...<br/><br/>R Müri, O Meienberg, D Wieser (1990) <i>Schweizerische medizinische Wochenschrift</i> <i></i> <i></i> 120: 34 1223-1227<br/>

//publicationslist.org/tobias.nef/refid329 2014-05-23T10:40:37Z

Müri RM, Meienberg O, Mändli B, Wyss B (1989) <i>Software-Kurier </i> 2: 49-51<br/>

//publicationslist.org/tobias.nef/refid316 2014-05-20T08:03:27Z

A self-developed software program is presented, by means of which it is possible to make routine recordings and automated analysis of slow eye movements in patients with suspected multiple sclerosis. The menu-guided program runs on an IBM/AT compatible personal computer and allows on-line survey of slow eye movements. Furthermore, interactive evaluation of the data is possible. Hard copies can be ...<br/><br/>R M Müri, T Grütter, O Meienberg, H Martin, B Wyss (1989) <i>Schweizer Archiv für Neurologie und Psychiatrie (Zurich, Switzerland : 1985)</i> <i></i> <i></i> 140: 1 44-46<br/>

//publicationslist.org/tobias.nef/refid317 2014-05-20T08:03:27Z

The eye movements of 100 patients with a definite diagnosis of multiple sclerosis were systematically examined using simple clinical tests, whose reliability had been first verified on 40 healthy controls. In 76 of the patients one or more eye movement disorders were observed. The most frequent finding was dissociation of the horizontal saccades due to mainly abortive forms of Internuclear Ophthal...<br/><br/>R M Müri, O Meienberg (1987) <i>Der Nervenarzt</i> <i></i> <i></i> 58: 3 171-174<br/>

//publicationslist.org/tobias.nef/refid330 2014-05-23T10:29:59Z

Müri RM, Meienberg O. (1987) <i>Nervenarzt</i> 58: 171-174<br/>

//publicationslist.org/tobias.nef/refid318 2014-05-20T08:03:27Z

R Muri, S Birkeland, A O Mølster (1986) <i>Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række</i> <i></i> <i></i> 106: 34-36 2985-6, 60<br/>

//publicationslist.org/tobias.nef/refid319 2014-05-20T08:03:27Z

Saccades were examined clinically and with an improved version of infrared reflection oculography in 79 patients with multiple sclerosis (31 definite, 17 probable, 31 possible cases). With regard to employing saccade recordings in the diagnosis of multiple sclerosis, suitability of saccadic parameters and examination technique for routine use was investigated. Accuracy and peak velocity of 30 degr...<br/><br/>O Meienberg, R Müri, P A Rabineau (1986) <i>Archives of neurology</i> <i></i> <i></i> 43: 5 438-443<br/>

//publicationslist.org/tobias.nef/refid331 2014-05-23T10:32:10Z

Hess CW, Müri RM, Meienberg O. (1986) <i>Neuro-ophthalmology</i> 6: 189-198<br/>

//publicationslist.org/tobias.nef/refid320 2014-05-20T08:03:27Z

The eye movements of 100 patients with multiple sclerosis were examined clinically, including a saccade test. Thirty-four cases of internuclear ophthalmoplegia were found, of which 14 were bilateral and 20 were unilateral. Only three patients had full restriction of adduction, whereas 16 had no restriction at all. A continuous dissociated nystagmus was present in one patient only, while in 15 just...<br/><br/>R M Müri, O Meienberg (1985) <i>Archives of neurology</i> <i></i> <i></i> 42: 9 851-855<br/>

//publicationslist.org/tobias.nef/refid335 2014-05-23T12:12:59Z

Müri, RM. () <i>Neuroanatomy of the oculomotor system </i> 503-26<br/>