http://publicationslist.org/data/tomas.hajek/atom.xml Tomas Hajekhttp://publicationslist.org/tomas.hajek$basepathfavicon.icoRecent additions to Tomas Hajek's PublicationsList.org pagehttp://publicationslist.org/publications.png2008-11-23T12:15:16Z http://publicationslist.org/tomas.hajek/refid7 2008-11-23T12:14:24Z

OBJECTIVE: Converging evidence suggests that the subgenual cingulate (SGC) is implicated in regulation of mood and in the pathophysiology of mood disorders. Our objective was to carry out the first meta-analysis of SGC volumes in patients with mood disorders. METHODS: We reviewed 10 volumetric magnetic resonance imaging studies of SGC volumes in patients with unipolar depression and bipolar disord...<br/><br/>Tomas Hajek, Jiri Kozeny, Miloslav Kopecek, Martin Alda, Cyril Höschl (2008) <i>J Psychiatry Neurosci</i> <i></i> <i></i> 33: 2 91-99<br/>

http://publicationslist.org/tomas.hajek/refid8 2008-11-23T12:14:24Z

BACKGROUND: Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have been identified. Decreased volumes of subgenual cingulate (SGC) were replicated in familial bipolar patients. Presence of abnormality in unaffected subjects at genetic risk for an illness needs to be established before SGC volumes can be used as an endophenotype. This is the f...<br/><br/>Tomas Hajek, Eva Gunde, Denise Bernier, Claire Slaney, Lukas Propper, Paul Grof, Glenda Macqueen, Anne Duffy, Martin Alda (2008) <i>J Affect Disord</i> <i></i> <i></i> 108: 3 263-269<br/>

http://publicationslist.org/tomas.hajek/refid10 2008-11-23T12:14:24Z

OBJECTIVE: To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder. METHODS: Retrospective chart review of response to antidepressants in "pre-bipolar" depression, compared to a matched unipolar sample. RESULTS: Family history of completed suicide (p=0.0003) and bipolar disorder (p=0.004) were more common in the pre-bipolar su...<br/><br/>Claire O'Donovan, Julie S Garnham, Tomas Hajek, Martin Alda (2008) <i>J Affect Disord</i> <i></i> <i></i> 107: 1-3 293-298<br/>

http://publicationslist.org/tomas.hajek/refid6 2008-11-23T12:14:24Z

BACKGROUND: Increased, decreased, as well as unchanged pituitary volumes have been reported in bipolar disorders (BD). It is unclear, whether abnormal pituitary volumes increase vulnerability for BD (primary vulnerability marker), or are secondary to burden of illness. To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipo...<br/><br/>Tomas Hajek, Eva Gunde, Denise Bernier, Claire Slaney, Lukas Propper, Glenda Macqueen, Anne Duffy, Martin Alda (2008) <i>Eur Arch Psychiatry Clin Neurosci</i> <i></i> <i></i> 258: 6 357-362<br/>

http://publicationslist.org/tomas.hajek/refid5 2008-11-23T12:14:24Z

OBJECTIVE: Rapid cycling (RC) affects 13-30% of bipolar patients. Most of the data regarding RC have been obtained in tertiary care research centers. Generalizability of these findings to primary care populations is thus questionable. We examined clinical and demographic factors associated with RC in both primary and tertiary care treated populations. METHOD: Clinical data were obtained by intervi...<br/><br/>Tomas Hajek, Margaret Hahn, Claire Slaney, Julie Garnham, Joshua Green, Martina Růzicková, Peter Zvolský, Martin Alda (2008) <i>Bipolar Disord</i> <i></i> <i></i> 10: 4 495-502<br/>

http://publicationslist.org/tomas.hajek/refid1 2008-11-23T12:14:24Z

BACKGROUND: The amygdala plays an important role in the regulation of emotions and has been implicated in the pathophysiology of mood disorders. Studies of amygdala volumes in mood disorders have been conflicting, with findings of increased, decreased and unchanged amygdala volumes in patients relative to controls. We present the largest meta-analysis of amygdala volumes in mood disorders and the ...<br/><br/> Hajek, Kopecek, Kozeny, Gunde, Alda, Höschl (2008) <i>J Affect Disord</i> <i></i> <i></i> : <br/>

http://publicationslist.org/tomas.hajek/refid2 2008-11-23T12:14:24Z

OBJECTIVE: Bipolar disorders have a strong genetic underpinning. Little is known about biological predispositions that convey vulnerability for the illness. We searched for biological vulnerability markers using proton magnetic resonance spectroscopy (MRS) in both affected and unaffected participants at high genetic risk for bipolar disorder. METHODS: We recruited high-risk participants aged 15-30...<br/><br/>Tomas Hajek, Denise Bernier, Claire Slaney, Lukas Propper, Matthias Schmidt, Normand Carrey, Glenda MacQueen, Anne Duffy, Martin Alda (2008) <i>J Psychiatry Neurosci</i> <i></i> <i></i> 33: 6 531-540<br/>

http://publicationslist.org/tomas.hajek/refid3 2008-11-23T12:14:24Z

Treatment of bipolar disorder (BD) has traditionally focused on alleviation of acute symptoms and prevention of future recurrences. Current treatment guide-lines advocate more or less similar treatment algorithms for all patients. Such approach largely ignores the clinical, genetic, and pathophysiological heterogeneity of BD, which makes certain patients more (or less) likely to respond to specifi...<br/><br/> Alda, Hajek, Calkin, O'Donovan (2008) <i>Ann Med</i> <i></i> <i></i> : 1-11<br/>

http://publicationslist.org/tomas.hajek/refid4 2008-11-23T12:14:24Z

OBJECTIVE: In accordance with the definition of health by the World Health Organization, outcome measures beyond mere syndromic recovery, such as quality of life ratings, would aid psychiatric practice and research. This is the first study of psychiatric diagnosis and illness stage specific profiles of subjective quality of life (SQOL) impairment. METHOD: Patients (n = 150) hospitalized at the Pra...<br/><br/>Eva Goppoldova, Eva Dragomirecka, Lucie Motlova, Tomas Hajek (2008) <i>Can J Psychiatry</i> <i></i> <i></i> 53: 9 587-593<br/>

http://publicationslist.org/tomas.hajek/refid9 2008-11-23T12:14:24Z

Margaret Hahn, Tomas Hajek, Martin Alda, Jack M Gorman (2007) <i>J Psychiatr Pract</i> <i></i> <i></i> 13: 5 336-338<br/>

http://publicationslist.org/tomas.hajek/refid11 2008-11-23T12:14:24Z

OBJECTIVES: The risk of suicidal behavior is substantially elevated in major affective disorders (AD). In bipolar disorder (BD), as many as 15% of patients may commit suicide and family history of suicide is recognized as one of the most important risk factors. Lithium reduces the rates of suicidal behavior in BD, especially in patients who achieve full mood stabilization. Yet even patients who co...<br/><br/>Patrizia Cavazzoni, Paul Grof, Anne Duffy, Eva Grof, Bruno Müller-Oerlinghausen, Anne Berghöfer, Bernd Ahrens, Petr Zvolsky, Carrie Robertson, Alison Davis, Tomas Hajek, Martin Alda (2007) <i>Bipolar Disord</i> <i></i> <i></i> 9: 4 377-385<br/>

http://publicationslist.org/tomas.hajek/refid12 2008-11-23T12:14:24Z

AIM: Previous studies have suggested altered structural and functional asymmetry of the brain in schizophrenia. METHODS: Functional MRI was used to assess differences in cortical activation during a verbal task in Broca's area and its contralateral homologue in four pairs of right-handed monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high familial loading for the i...<br/><br/>Filip Spaniel, Jaroslav Tintera, Tomas Hajek, Jiri Horacek, Monika Dezortova, Milan Hajek, Colleen Dockery, Jiri Kozeny, Cyril Höschl (2007) <i>Eur Psychiatry</i> <i></i> <i></i> 22: 5 319-322<br/>

http://publicationslist.org/tomas.hajek/refid13 2008-11-23T12:14:24Z

PURPOSE: Decreased hippocampal volume reported in neuropsychiatric and endocrine disorders is considered a result of putative neuronal damage mediated by corticosteroids. This is the first prospective study of hippocampal volume and function in patients treated with corticosteroids. METHODS: 14 subjects treated systemically with prednisone or betamethasone for dermatological or rheumatic disorders...<br/><br/>Tomás Hájek, Miloslav Kopecek, Marek Preiss, Martin Alda, Cyril Höschl (2006) <i>Eur Psychiatry</i> <i></i> <i></i> 21: 2 123-128<br/>

http://publicationslist.org/tomas.hajek/refid14 2008-11-23T12:14:24Z

PURPOSE: Borrelia burgdorferi (Bb) infection can affect the central nervous system and possibly lead to psychiatric disorders. We compared clinical and demographic variables in Bb seropositive and seronegative psychiatric patients and healthy controls. METHOD: Nine hundred and twenty-six consecutive psychiatric patients were screened for antibodies to Bb and compared with 884 simultaneously recrui...<br/><br/>T Hájek, J Libiger, D Janovská, P Hájek, M Alda, C Höschl (2006) <i>Eur Psychiatry</i> <i></i> <i></i> 21: 2 118-122<br/>

http://publicationslist.org/tomas.hajek/refid18 2008-11-23T12:14:24Z

OBJECTIVES: In this study we examined general assessment of functioning (GAF), and its relation to clinical and demographic factors in bipolar patients. A number of studies, mostly from specialized programs, show that bipolar disorder often leads to occupational and social impairment. Here we report data from patients in a primary care setting. METHODS: A total of 252 patients from the Maritime Bi...<br/><br/>Tomas Hajek, Claire Slaney, Julie Garnham, Martina Ruzickova, Michael Passmore, Martin Alda (2005) <i>Bipolar Disord</i> <i></i> <i></i> 7: 3 286-291<br/>

http://publicationslist.org/tomas.hajek/refid19 2008-11-23T12:14:24Z

T1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14...<br/><br/>Filip Spaniel, Vit Herynek, Tomas Hajek, Monika Dezortova, Jiri Horacek, Milan Hajek, Jiri Kozeny, Colleen Dockery, Cyril Höschl (2005) <i>Eur Psychiatry</i> <i></i> <i></i> 20: 1 41-44<br/>

http://publicationslist.org/tomas.hajek/refid17 2008-11-23T12:14:24Z

F Spaniel, J Tintera, T Hájek, J Horacek, M Dezortova, M Hájek (2005) <i>Br J Psychiatry</i> <i></i> <i></i> 186: 444; author reply 444-444; author reply 445<br/>

http://publicationslist.org/tomas.hajek/refid16 2008-11-23T12:14:24Z

The search for susceptibility genes for bipolar disorder (BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-term course, comorbid conditions, and response to prophylactic treatment may define ...<br/><br/>G M MacQueen, T Hajek, M Alda (2005) <i>Mol Psychiatry</i> <i></i> <i></i> 10: 9 811-826<br/>

http://publicationslist.org/tomas.hajek/refid15 2008-11-23T12:14:24Z

OBJECTIVE: Neuroimaging studies show structural brain abnormalities in bipolar patients. Some of the abnormalities may represent biological risk factors conveying vulnerability for the disease. This paper aims to identify neuroanatomical risk factors for bipolar disorder (BD). METHODS: We reviewed magnetic resonance imaging (MRI) findings in populations in which the effects of the disease or treat...<br/><br/>Tomas Hajek, Normand Carrey, Martin Alda (2005) <i>Bipolar Disord</i> <i></i> <i></i> 7: 5 393-403<br/>

http://publicationslist.org/tomas.hajek/refid20 2008-11-23T12:14:24Z

OBJECTIVE: This paper presents functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) findings in a monozygotic twin pair discordant for schizophrenia. METHOD: Functional magnetic resonance imaging was used to determine hemispheric lateralization for speech and proton MRS (1H-MRS) was employed to assess the extent of putative insult to anterior hippocampus. RESULTS:...<br/><br/>F Spaniel, T Hájek, J Tintera, P Harantová, M Dezortová, M Hájek (2003) <i>Acta Psychiatr Scand</i> <i></i> <i></i> 107: 2 155-158<br/>

http://publicationslist.org/tomas.hajek/refid22 2008-11-23T12:14:24Z

OBJECTIVE: Borrelia burgdorferi infection can affect the CNS and mimic psychiatric disorders. It is not known whether Borrelia burgdorferi contributes to overall psychiatric morbidity. The authors compared the prevalence of antibodies to Borrelia burgdorferi in groups of psychiatric patients and healthy subjects to find out whether there is an association between this infection and psychiatric mor...<br/><br/>Tomás Hájek, Beáta Pasková, Daniela Janovská, Radvan Bahbouh, Peter Hájek, Jan Libiger, Cyril Höschl (2002) <i>Am J Psychiatry</i> <i></i> <i></i> 159: 2 297-301<br/>

http://publicationslist.org/tomas.hajek/refid21 2008-11-23T12:14:24Z

There is an increasing evidence that corticosteroids damage the hippocampus in rodents and in primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory ...<br/><br/>C Höschl, T Hajek (2001) <i>Eur Arch Psychiatry Clin Neurosci</i> <i></i> <i></i> 251 Suppl 2: II81-II88<br/>