Vincent Karam's Publications List

Liver transplantation for erythropoietic protoporphyria in Europe.

2012-01-26T22:10:10Z

Liver transplantation is an established lifesaving treatment for patients with severe protoporphyric liver disease, but disease recurrence in the graft occurs for the majority of recipients. Severe burn injuries may occur when protective light filters are not used with surgical luminaires. Motor neuropathy with an unclear pathogenesis is a frequent complication. We retrospectively studied 35 trans...

Staffan Wahlin, Per Stal, Rene Adam, Vincent Karam, Robert Porte, Daniel Seehofer, Bridget K Gunson, Jens Hillingsø, Jürgen L Klempnauer, Jan Schmidt, Graeme Alexander, John O'Grady, Pierre-Alain Clavien, Mauro Salizzoni, Andreas Paul, Keith Rolles, Bo-Göran Ericzon, Pauline Harper (2011) Liver Transpl 17: 9 1021-1026

Significance of isolated hepatic veno-occlusive disease/sinusoidal obstruction syndrome after liver transplantation.

2012-01-26T22:10:10Z

After liver transplantation (LT), hepatic veno-occlusive disease (VOD), which is also known as sinusoidal obstruction syndrome (SOS), has been reported initially in relation to azathioprine use and subsequently in relation to acute rejection (AR). Isolated veno-occlusive disease (iVOD)/SOS raises some questions about its significance and especially its treatment. From the post-LT biopsy samples of...

Mylène Sebagh, Daniel Azoulay, Bruno Roche, Emir Hoti, Vincent Karam, Elina Teicher, Laurence Bonhomme-Faivre, Faouzi Saliba, Jean-Charles Duclos-Vallée, Didier Samuel (2011) Liver Transpl 17: 7 798-808

Symptomatic and proven de novo amyloid polyneuropathy in familial amyloid polyneuropathy domino liver recipients.

2012-01-26T22:10:10Z

D Adams, C Lacroix, T Antonini, P Lozeron, C Denier, A M Kreib, S Epelbaum, F Blandin, V Karam, D Azoulay, R Adam, D Castaing, D Samuel (2011) Amyloid 18 Suppl 1: 169-172

Short- and long-term donor morbidity in right lobe living donor liver transplantation: 91 consecutive cases in a European Center.

2012-01-26T22:10:10Z

The lack of use of a common grading system in reporting morbidity impedes estimation of the true risk to a right lobe living donor (RLLD). We report outcomes in 91 consecutive RLLD's using the validated 5-tier Clavien grading and a quality of life (QOL) questionnaire. The median follow-up was 79 months. The donors were predominantly female (66%), 22 (24%) received autologous blood transfusions. Fi...

D Azoulay, P Bhangui, P Andreani, C Salloum, V Karam, E Hoti, G Pascal, R Adam, D Samuel, Ph Ichai, F Saliba, D Castaing (2011) Am J Transplant 11: 1 101-110

Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.

2012-01-26T22:10:10Z

BACKGROUND & AIMS: Most liver transplant centres have discontinued the practice of protocol liver biopsies (LB), mainly because of the perceived lack of therapeutic benefit. This study aimed to examine the usefulness of 20-year LBs. METHODS: Ten, 15, and 20-year protocol LBs from 147 patients surviving for >20years were reviewed. Twenty-year biopsy findings were correlated with clinical data. RESU...

Mylène Sebagh, Didier Samuel, Teresa Maria Antonini, Audrey Coilly, Davide Degli Esposti, Bruno Roche, Vincent Karam, Alexandre Dos Santos, Jean-Charles Duclos-Vallée, Anne-Marie Roque-Afonso, Eric Ballot, Catherine Guettier, Frédérique Blandin, Faouzi Saliba, Daniel Azoulay (2011) J Hepatol :

Primary liver transplantation for autoimmune hepatitis: a comparative analysis of the European Liver Transplant Registry.

2012-01-26T22:10:10Z

The principal aim of this study was to compare the probability of and potential risk factors for death and graft loss after primary adult and pediatric liver transplantation in patients undergoing transplantation for autoimmune hepatitis (AIH) to those in patients undergoing transplantation for primary biliary cirrhosis (PBC; used as the reference group) or alcoholic cirrhosis (used as an example ...

Christoph Schramm, Michael Bubenheim, René Adam, Vincent Karam, John Buckels, John G O'Grady, Neville Jamieson, Stephen Pollard, Peter Neuhaus, Michael M Manns, Robert Porte, Denis Castaing, Andreas Paul, Oscar Traynor, James Garden, Styrbjörn Friman, Bo-Goran Ericzon, Lutz Fischer, Stefan Vitko, Marek Krawczyk, Herold J Metselaar, Aksel Foss, Murat Kilic, Keith Rolles, Patrizia Burra, Xavier Rogiers, Ansgar W Lohse (2010) Liver Transpl 16: 4 461-469

Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry).

2012-01-26T22:10:10Z

Alcohol-related liver disease (ALD) is one of the most common indications for liver transplantation (LT). Long-term outcome after LT for ALD versus other etiologies is still under debate. The aim of this study was to compare outcome after LT of patients with ALD, viral (VIR), and cryptogenic cirrhosis. Donor, graft and recipient ELTR variables were analysed in transplants for alcoholic and nonalco...

P Burra, M Senzolo, R Adam, V Delvart, V Karam, G Germani, J Neuberger (2010) Am J Transplant 10: 1 138-148

Towards a better liver transplant allocation system.

2012-01-26T22:10:10Z

A K Burroughs, L Marelli, E Cholongitas, P Manousou, K Rolles, V Karam, V Delvart, R Adam, C Sabin (2007) Liver Transpl 13: 6 935-6; author reply 937

The place of liver transplantation in the treatment of hepatic epitheloid hemangioendothelioma: report of the European liver transplant registry.

2012-01-26T22:10:10Z

Hepatic epitheloid hemangioendothelioma (HEHE) is a rare low-grade vascular tumor. Its treatment algorithm is still unclear mainly due to a lack of larger clinical experiences with detailed long-term follow-up.

Jan P Lerut, Giuseppe Orlando, Rene Adam, Marcello Schiavo, Jurgen Klempnauer, Darius Mirza, Emmanuel Boleslawski, Andrew Burroughs, Carlos Fernandez Sellés, Daniel Jaeck, Robert Pfitzmann, Mauro Salizzoni, Gunner Söderdahl, Rudi Steininger, Andre Wettergren, Vincenzo Mazzaferro, Yves Patrice Le Treut, Vincent Karam (2007) Ann Surg 246: 6 949-57; discussion 957

Adult liver transplantation: the Paul Brousse experience.

2012-01-26T22:10:10Z

During the past 3 decades, more than 2,250 liver transplants were performed at Paul Brousse Hospital. Overall patient survival was 82% at one year, 71% at 5 years and 64% at 10 years. Our group has developed a variety of approaches to liver transplantation, including: 1. Anti HBs immunoglobulin prophylaxis for the prevention of HBV recurrence. Combination prophylaxis with lamivudine and anti HBs i...

D Castaing, C Salloum, D Azoulay, R Adam, E Vibert, L A Veilhan, V Karam, F Saliba, Ph Ichaï, D Samuel (2007) Clin Transpl : 145-154

Liver transplantation for hereditary hemorrhagic telangiectasia: Report of the European liver transplant registry.

2012-01-26T22:14:33Z

Hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease is a rare disease characterized by the presence of arteriovenous malformations. Hepatic involvement can lead to life-threatening conditions.

Jan Lerut, Giuseppe Orlando, René Adam, Carlo Sabbà, Robert Pfitzmann, Jurgen Klempnauer, Jacques Belghiti, Jacques Pirenne, Thierry Thevenot, Christian Hillert, Colin M Brown, Dominique Gonze, Vincent Karam, Olivier Boillot (2006) Ann Surg 244: 6 854-62; discussion 862-4

3-month and 12-month mortality after first liver transplant in adults in Europe: predictive models for outcome.

2012-01-26T22:04:59Z

BACKGROUND: Mortality after liver transplantation depends on heterogeneous recipient and donor factors. Our aim was to assess risk of death and to develop models to help predict mortality after liver transplantation. METHODS: We analysed data from 34,664 first adult liver transplants from the European Liver Transplant Registry to identify factors associated with mortality at 3-months (n=21,605 in ...

Andrew K Burroughs, Caroline A Sabin, Keith Rolles, Valerie Delvart, Vincent Karam, John Buckels, John G O'Grady, Denis Castaing, Jurgen Klempnauer, Neville Jamieson, Peter Neuhaus, Jan Lerut, Jean de Ville de Goyet, Stephen Pollard, Mauro Salizzoni, Xavier Rogiers, Ferdinand Muhlbacher, Juan Carlos Garcia Valdecasas, Christopher Broelsch, Daniel Jaeck, Joaquin Berenguer, Enrique Moreno Gonzalez, Rene Adam (2006) Lancet 367: 9506 225-232

Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases.

2012-01-26T22:14:33Z

Preoperative chemotherapy for colorectal liver metastases (CLM) can produce histologic changes in the nontumor-bearing liver (NTBL) that may impact on surgical outcomes.

Thomas Aloia, Mylène Sebagh, Marylène Plasse, Vincent Karam, Francis Lévi, Sylvie Giacchetti, Daniel Azoulay, Henri Bismuth, Denis Castaing, René Adam (2006) J Clin Oncol 24: 31 4983-4990

The place of liver transplantation in Caroli's disease and syndrome.

2012-01-26T22:14:33Z

Caroli's disease (CD) or syndrome (CS) are rare inherited disorders which may cause severe, life-threatening, cholangitis or which may lead to hepatobiliary degeneration. The typical cystic biliary anomalies are often associated to congenital hepatic fibrosis (CHF) and, less frequently, to cystic renal disease especially autosomic recessive polycystic kidney disease (ARPKD). The place of liver tra...

Laurent De Kerckhove, Martine De Meyer, Catherine Verbaandert, Michel Mourad, Etienne Sokal, Pierre Goffette, Andre Geubel, Vincent Karam, Rene Adam, Jan Lerut (2006) Transpl Int 19: 5 381-388

Cadaveric full-size liver transplantation and the graft alternatives in adults: a comparative study from a single centre.

2012-01-26T22:14:33Z

This study aims to compare the results of living donor (LDLT), cadaveric split (SLT) and domino (DO) liver transplantation which are currently available alternatives to the conventional cadaveric full-size liver transplantation (CAD).

Mylène Sebagh, Funda Yilmaz, Vincent Karam, Bruno Falissard, Philippe Ichaï, Bruno Roche, Denis Castaing, Catherine Guettier, Didier Samuel, Daniel Azoulay (2006) J Hepatol 44: 1 118-125

Liver transplantation in Europe: is there a room for improvement?

2012-01-26T22:14:33Z

René Adam, Valerio Lucidi, Vincent Karam (2005) J Hepatol 42: 1 33-40

The histologic pattern of "biliary tract pathology" is accurate for the diagnosis of biliary complications.

2012-01-26T22:14:33Z

A histologic pattern comprising centrilobular cholestasis and portal changes including edema, predominantly neutrophil polymorph infiltration, cholangiolar proliferation, and cholangiolitis is well known to correspond to biliary obstruction. This pattern, referred as biliary tract pathology (BTP) in this text, remains unclear in terms of its clinical significance. We aimed to assess the incidence,...

Mylène Sebagh, Funda Yilmaz, Vincent Karam, Bruno Falissard, Bruno Roche, Daniel Azoulay, Didier Samuel, Catherine Guettier (2005) Am J Surg Pathol 29: 3 318-323

Herpes simplex virus-associated acute liver failure: a difficult diagnosis with a poor prognosis.

2012-01-26T22:14:33Z

We report 5 cases of acute liver failure related to herpes simplex (HSV) infection in 1 immunocompetent and 4 immunosuppressed patients. One patient was too ill for liver transplantation indication. Three patients, among the 4 listed, underwent liver transplantation. Three patients died 11 days to 1 year after transplantation and 2 patients died 2 to 3 days after admission. All presented with feve...

Philippe Ichai, Anne Marie Roque Afonso, Mylène Sebagh, Maria Eugenia Gonzalez, Liana Codés, Daniel Azoulay, Faouzi Saliba, Vincent Karam, Elisabeth Dussaix, Catherine Guettier, Denis Castaing, Didier Samuel (2005) Liver Transpl 11: 12 1550-1555

Donor age influences 10-year liver graft histology independently of hepatitis C virus infection.

2012-01-26T22:14:33Z

Factors influencing the long-term histological outcome of liver graft are not known. We conducted a prospective study based on a 10-year liver biopsy in order to identify the main factors influencing long-term graft histology.

Kinan Rifai, Mylène Sebagh, Vincent Karam, Faouzi Saliba, Daniel Azoulay, René Adam, Denis Castaing, Henri Bismuth, Michel Reynès, Didier Samuel, Cyrille Féray (2004) J Hepatol 41: 3 446-453

A 10 year follow up study of patients transplanted for autoimmune hepatitis: histological recurrence precedes clinical and biochemical recurrence.

2012-01-26T22:15:51Z

Autoimmune hepatitis (AIH) has been reported to recur after orthotopic liver transplantation (OLT) in 10-35% of patients in small series with a short follow up. The aim of the present study was to examine the clinical and histological outcome more than 10 years after OLT for AIH.

J-C Duclos-Vallée, M Sebagh, K Rifai, C Johanet, E Ballot, C Guettier, V Karam, M Hurtova, C Feray, M Reynes, H Bismuth, D Samuel (2003) Gut 52: 6 893-897

Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation.

2012-01-26T22:15:51Z

We assessed the impact of liver transplantation (LT) on the quality of life (QOL) of French recipients 1 year after surgery. A French version of the questionnaire used by the National Institute of Diabetes and Digestive and Kidney Disease-Pittsburg, USA (NIDDK), was validated by the back-translation method. Five QOL domains were evaluated: measures of disease, psychological distress, personal func...

Vincent Karam, Denis Castaing, Colette Danet, Valérie Delvart, Isabelle Gasquet, René Adam, Daniel Azoulay, Didier Samuel, Henri Bismuth (2003) Liver Transpl 9: 7 703-711

Quality of life in adult survivors beyond 10 years after liver, kidney, and heart transplantation.

2012-01-26T22:15:51Z

The yearly increasing survival rates testify to the success of transplantation, but questions remain relating to the quality of life (QOL) associated with long-term survival.

Vincent H Karam, Isabelle Gasquet, Valérie Delvart, Christian Hiesse, Richard Dorent, Colette Danet, Didier Samuel, Bernard Charpentier, Iradj Gandjbakhch, Henri Bismuth, Denis Castaing (2003) Transplantation 76: 12 1699-1704

Quality control of the European Liver Transplant Registry: results of audit visits to the contributing centers.

2012-01-26T22:15:51Z

The number of registries is increasing, but few of them perform reliability audits by comparing the data contained in the database with data contained in hospital charts.

Vincent Karam, Bridget Gunson, Francine Roggen, Luis Grande, Wolfgang Wannoff, Magda Janssen, Olaf Guckelberger, Valérie Delvart, Henri Bismuth, Krister Höckerstedt, Xavier Rogiers, René Adam (2003) Transplantation 75: 12 2167-2173

Split-liver transplantation for two adult recipients: feasibility and long-term outcomes.

2012-01-26T22:15:51Z

To identify the outcomes and risks of split-liver transplantation (SLT) for two adult recipients to determine the feasibility of more widespread use of this procedure to increase the graft pool for adults.

D Azoulay, D Castaing, R Adam, E Savier, V Delvart, V Karam, B Y Ming, M Dannaoui, J Krissat, H Bismuth (2001) Ann Surg 233: 4 565-574

Auxiliary partial orthotopic versus standard orthotopic whole liver transplantation for acute liver failure: a reappraisal from a single center by a case-control study.

2012-01-26T22:15:51Z

To reappraise the results of auxiliary partial orthotopic liver transplantation (APOLT) compared with those of standard whole-liver transplantation (OLT) in terms of postoperative death and complications, including neurologic sequelae.

D Azoulay, D Samuel, P Ichai, D Castaing, F Saliba, R Adam, E Savier, M Danaoui, A Smail, V Delvart, V Karam, H Bismuth (2001) Ann Surg 234: 6 723-731

Normalised intrinsic mortality risk in liver transplantation: European Liver Transplant Registry study.

2012-01-26T22:15:51Z

No model exists for liver transplantation to estimate the mortality risk in a given patient, and no standard by which to assess performance in different centres. We investigated the intrinsic mortality risk in the absence of known mortality risk factors.

R Adam, V Cailliez, P Majno, V Karam, P McMaster, R Y Caine, J O'Grady, R Pichlmayr, P Neuhaus, J B Otte, K Hoeckerstedt, H Bismuth (2000) Lancet 356: 9230 621-627

Paul Brousse Liver Transplantation: the first 1,500 cases.

2012-01-26T22:15:51Z

During the past 16 years, more than 1,500 liver transplants were performed at Paul Brousse Hospital. The overall patient survival rates were 83% at one year and 65% at 10 years. Our group has pioneered a variety of new approaches to liver transplantation, including: 1. Anti-HBs (HBIG) prophylaxis for the prevention of HBV recurrence. To date more than 270 patients have received long-term treatment...

D Azoulay, D Samuel, R Adam, E Savier, V Karam, V Delvard, F Saliba, P Ichai, B Roche, C Feray, J C Vallee, A Smail, D Castaing, H Bismuth (2000) Clin Transpl : 273-280