Volkmar Hans's Publications List

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.

2018-12-14T08:59:36Z

Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors as a separate entity has not yet been conclusively demonstrated and molecular features have only been partia...

Annekathrin Reinhardt, Damian Stichel, Daniel Schrimpf, Felix Sahm, Andrey Korshunov, David E Reuss, Christian Koelsche, Kristin Huang, Annika K Wefers, Volker Hovestadt, Martin Sill, Dorothee Gramatzki, Joerg Felsberg, Guido Reifenberger, Arend Koch, Ulrich-W Thomale, Albert Becker, Volkmar H Hans, Marco Prinz, Ori Staszewski, Till Acker, Hildegard Dohmen, Christian Hartmann, Wolf Mueller, Muin S A Tuffaha, Werner Paulus, Katharina Heß, Benjamin Brokinkel, Jens Schittenhelm, Camelia-Maria Monoranu, Almuth Friederike Kessler, Mario Loehr, Rolf Buslei, Martina Deckert, Christian Mawrin, Patricia Kohlhof, Ekkehard Hewer, Adriana Olar, Fausto J Rodriguez, Caterina Giannini, Amulya A NageswaraRao, Uri Tabori, Nuno Miguel Nunes, Michael Weller, Ute Pohl, Zane Jaunmuktane, Sebastian Brandner, Andreas Unterberg, Daniel Hänggi, Michael Platten, Stefan M Pfister, Wolfgang Wick, Christel Herold-Mende, David T W Jones, Andreas von Deimling, David Capper (2018) Acta neuropathologica 136: 2 273-291

ATPase N-ethylmaleimide-sensitive Fusion Protein: A Novel Key Player for Causing Spontaneous Network Excitation in Human Temporal Lobe Epilepsy.

2018-12-14T08:59:36Z

The molecular basis for onset, maintenance and propagation of excitation along neuronal networks in epilepsy is still poorly understood. Besides different neurotransmitter receptors that control signal transfer at the synapse, one key regulator involved in all of these processes is the ATPase N-ethylmaleimide-sensitive fusion protein (NSF). Therefore, we analyzed receptor subunits and NSF levels i...

Christina Herold, Hans-Jürgen Bidmon, Heinz W Pannek, Volkmar Hans, Ali Gorji, Erwin-Josef Speckmann, Karl Zilles (2018) Neuroscience 371: 371-383

Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location.

2018-03-04T21:32:36Z

The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). Tumors of this entity arise in CNS midline structures of predominantly pediatric patients and are associated with an overall dismal prognosis. They are defined by K27M mutations in H3F3A or HIST1H3B/C...

Michael Karremann, Gerrit H Gielen, Marion Hoffmann, Maria Wiese, Niclas Colditz, Monika Warmuth-Metz, Brigitte Bison, Alexander Claviez, Dannis G van Vuurden, André O von Bueren, Marco Gessi, Ingrid Kühnle, Volkmar H Hans, Martin Benesch, Dominik Sturm, Rolf-Dieter Kortmann, Andreas Waha, Torsten Pietsch, Christof M Kramm (2018) Neuro-oncology 20: 1 123-131

DNA methylation-based classification of central nervous system tumours.

2018-12-14T08:59:36Z

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for...

David Capper, David T W Jones, Martin Sill, Volker Hovestadt, Daniel Schrimpf, Dominik Sturm, Christian Koelsche, Felix Sahm, Lukas Chavez, David E Reuss, Annekathrin Kratz, Annika K Wefers, Kristin Huang, Kristian W Pajtler, Leonille Schweizer, Damian Stichel, Adriana Olar, Nils W Engel, Kerstin Lindenberg, Patrick N Harter, Anne K Braczynski, Karl H Plate, Hildegard Dohmen, Boyan K Garvalov, Roland Coras, Annett Hölsken, Ekkehard Hewer, Melanie Bewerunge-Hudler, Matthias Schick, Roger Fischer, Rudi Beschorner, Jens Schittenhelm, Ori Staszewski, Khalida Wani, Pascale Varlet, Melanie Pages, Petra Temming, Dietmar Lohmann, Florian Selt, Hendrik Witt, Till Milde, Olaf Witt, Eleonora Aronica, Felice Giangaspero, Elisabeth Rushing, Wolfram Scheurlen, Christoph Geisenberger, Fausto J Rodriguez, Albert Becker, Matthias Preusser, Christine Haberler, Rolf Bjerkvig, Jane Cryan, Michael Farrell, Martina Deckert, Jürgen Hench, Stephan Frank, Jonathan Serrano, Kasthuri Kannan, Aristotelis Tsirigos, Wolfgang Brück, Silvia Hofer, Stefanie Brehmer, Marcel Seiz-Rosenhagen, Daniel Hänggi, Volkmar Hans, Stephanie Rozsnoki, Jordan R Hansford, Patricia Kohlhof, Bjarne W Kristensen, Matt Lechner, Beatriz Lopes, Christian Mawrin, Ralf Ketter, Andreas Kulozik, Ziad Khatib, Frank Heppner, Arend Koch, Anne Jouvet, Catherine Keohane, Helmut Mühleisen, Wolf Mueller, Ute Pohl, Marco Prinz, Axel Benner, Marc Zapatka, Nicholas G Gottardo, Pablo Hernáiz Driever, Christof M Kramm, Hermann L Müller, Stefan Rutkowski, Katja von Hoff, Michael C Frühwald, Astrid Gnekow, Gudrun Fleischhack, Stephan Tippelt, Gabriele Calaminus, Camelia-Maria Monoranu, Arie Perry, Chris Jones, Thomas S Jacques, Bernhard Radlwimmer, Marco Gessi, Torsten Pietsch, Johannes Schramm, Gabriele Schackert, Manfred Westphal, Guido Reifenberger, Pieter Wesseling, Michael Weller, Vincent Peter Collins, Ingmar Blümcke, Martin Bendszus, Jürgen Debus, Annie Huang, Nada Jabado, Paul A Northcott, Werner Paulus, Amar Gajjar, Giles W Robinson, Michael D Taylor, Zane Jaunmuktane, Marina Ryzhova, Michael Platten, Andreas Unterberg, Wolfgang Wick, Matthias A Karajannis, Michel Mittelbronn, Till Acker, Christian Hartmann, Kenneth Aldape, Ulrich Schüller, Rolf Buslei, Peter Lichter, Marcel Kool, Christel Herold-Mende, David W Ellison, Martin Hasselblatt, Matija Snuderl, Sebastian Brandner, Andrey Korshunov, Andreas von Deimling, Stefan M Pfister (2018) Nature 555: 7697 469-474

Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features.

2018-12-14T08:59:36Z

Ependymoma with YAP1-MAMLD1 fusion is a rare, recently described supratentorial neoplasm of childhood, with few cases published so far. We report on 15 pediatric patients with ependymomas carrying YAP1-MAMLD1 fusions, with their characteristic histopathology, immunophenotype and molecular/cytogenetic, radiological and clinical features. The YAP1-MAMLD1 fusion was documented by RT-PCR/Sanger sequen...

Felipe Andreiuolo, Pascale Varlet, Arnault Tauziède-Espariat, Stephanie T Jünger, Evelyn Dörner, Verena Dreschmann, Klaus Kuchelmeister, Andreas Waha, Christine Haberler, Irene Slavc, Selim Corbacioglu, Markus J Riemenschneider, Alfred Leipold, Thomas Rüdiger, Dieter Körholz, Till Acker, Alexandra Russo, Jörg Faber, Clemens Sommer, Sven Armbrust, Martina Rose, Bernhard Erdlenbruch, Volkmar H Hans, Benedikt Bernbeck, Dominik Schneider, Johann Lorenzen, Martin Ebinger, Rupert Handgretinger, Manuela Neumann, Miriam van Buiren, Marco Prinz, Jelena Roganovic, Antonia Jakovcevic, Sung-Hye Park, Jacques Grill, Stéphanie Puget, Martina Messing-Jünger, Harald Reinhard, Markus Bergmann, Elke Hattingen, Torsten Pietsch (2018) Brain pathology (Zurich, Switzerland) :

Directional spread of activity in synaptic networks of the human lateral amygdala.

2018-03-04T21:32:36Z

Spontaneous epileptiform activity has previously been observed in lateral amygdala (LA) slices derived from patients with intractable-temporal lobe epilepsy. The present study aimed to characterize intranuclear LA synaptic connectivity and to test the hypothesis that differences in the spread of flow of neuronal activity may relate to spontaneous epileptiform activity occurrence. Electrical activi...

Stéphanie Graebenitz, Manuela Cerina, Jörg Lesting, Olga Kedo, Ali Gorji, Heinz Pannek, Volkmar Hans, Karl Zilles, Hans-Christian Pape, Erwin-Josef Speckmann (2017) Neuroscience 349: 330-340

Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis.

2018-03-04T21:32:36Z

Onconeural antibodies are associated with cancer and paraneoplastic encephalitis. While their pathogenic role is still largely unknown, their high diagnostic value is undisputed. In this study we describe the discovery of a novel target of autoimmunity in an index case of paraneoplastic encephalitis associated with urogenital cancer.A 75-year-old man with a history of invasive bladder carcinoma 6 ...

Stoyan Popkirov, Ilya Ayzenberg, Stefanie Hahn, Jan Bauer, Yvonne Denno, Nicole Rieckhoff, Christiane Radzimski, Volkmar H Hans, Sebastian Berg, Florian Roghmann, Joachim Noldus, Christian G Bien, Sabine Skodda, Jörg Wellmer, Winfried Stöcker, Christos Krogias, Ralf Gold, Uwe Schlegel, Christian Probst, Lars Komorowski, Ramona Miske, Ingo Kleiter (2017) Acta neuropathologica communications 5: 1

Pituitary apoplexy - A single center retrospective study from the neurosurgical perspective and review of the literature.

2018-03-04T21:32:36Z

Thunderclap headache and visual disturbances are typical clinical features of pituitary apoplexy (PA). Because of the acute symptomatology, many patients are referred to a neurosurgical department without prior endocrinological assessment. It is the aim of the present study to analyze initial presenting symptoms, outcome and associated endocrine disturbances in a cohort of patients with pituitary ...

Agnieszka Grzywotz, Bernadette Kleist, Lars C Möller, Volkmar H Hans, Sophia Göricke, Ulrich Sure, Oliver Müller, Ilonka Kreitschmann-Andermahr (2017) Clinical neurology and neurosurgery 163: 39-45

A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma - A final report.

2018-03-04T21:39:06Z

The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection.

Astrid K Gnekow, David A Walker, Daniela Kandels, Susan Picton, Giorgio Perilongo, Jacques Grill, Tore Stokland, Per Eric Sandstrom, Monika Warmuth-Metz, Torsten Pietsch, Felice Giangaspero, René Schmidt, Andreas Faldum, Denise Kilmartin, Angela De Paoli, Gian Luca De Salvo, and collaborators (2017) European journal of cancer (Oxford, England : 1990) 81: 206-225

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

2016-08-08T08:18:44Z

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined ...

Dominik Sturm, Brent A Orr, Umut H Toprak, Volker Hovestadt, David T W Jones, David Capper, Martin Sill, Ivo Buchhalter, Paul A Northcott, Irina Leis, Marina Ryzhova, Christian Koelsche, Elke Pfaff, Sariah J Allen, Gnanaprakash Balasubramanian, Barbara C Worst, Kristian W Pajtler, Sebastian Brabetz, Pascal D Johann, Felix Sahm, Jüri Reimand, Alan Mackay, Diana M Carvalho, Marc Remke, Joanna J Phillips, Arie Perry, Cynthia Cowdrey, Rachid Drissi, Maryam Fouladi, Felice Giangaspero, Maria Łastowska, Wiesława Grajkowska, Wolfram Scheurlen, Torsten Pietsch, Christian Hagel, Johannes Gojo, Daniela Lötsch, Walter Berger, Irene Slavc, Christine Haberler, Anne Jouvet, Stefan Holm, Silvia Hofer, Marco Prinz, Catherine Keohane, Iris Fried, Christian Mawrin, David Scheie, Bret C Mobley, Matthew J Schniederjan, Mariarita Santi, Anna M Buccoliero, Sonika Dahiya, Christof M Kramm, André O von Bueren, Katja von Hoff, Stefan Rutkowski, Christel Herold-Mende, Michael C Frühwald, Till Milde, Martin Hasselblatt, Pieter Wesseling, Jochen Rößler, Ulrich Schüller, Martin Ebinger, Jens Schittenhelm, Stephan Frank, Rainer Grobholz, Istvan Vajtai, Volkmar Hans, Reinhard Schneppenheim, Karel Zitterbart, V Peter Collins, Eleonora Aronica, Pascale Varlet, Stephanie Puget, Christelle Dufour, Jacques Grill, Dominique Figarella-Branger, Marietta Wolter, Martin U Schuhmann, Tarek Shalaby, Michael Grotzer, Timothy van Meter, Camelia-Maria Monoranu, Jörg Felsberg, Guido Reifenberger, Matija Snuderl, Lynn Ann Forrester, Jan Koster, Rogier Versteeg, Richard Volckmann, Peter van Sluis, Stephan Wolf, Tom Mikkelsen, Amar Gajjar, Kenneth Aldape, Andrew S Moore, Michael D Taylor, Chris Jones, Nada Jabado, Matthias A Karajannis, Roland Eils, Matthias Schlesner, Peter Lichter, Andreas von Deimling, Stefan M Pfister, David W Ellison, Andrey Korshunov, Marcel Kool (2016) Cell 164: 5 1060-1072

Erratum: Histological criteria for atypical pituitary adenomas - data from the German pituitary adenoma registry suggests modifications.

2016-04-11T10:31:39Z

Christian P Miermeister, Stephan Petersenn, Michael Buchfelder, Rudolf Fahlbusch, Dieter K Lüdecke, Annett Hölsken, Markus Bergmann, Ulrich Johannes Knappe, Volkmar H Hans, Jörg Flitsch, Wolfgang Saeger, Rolf Buslei (2016) Acta neuropathologica communications 4: 1

Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry.

2018-03-04T21:32:36Z

A novel vacuum stable proton sponge, 4-maleicanhydridoproton sponge (MAPS), was prepared and applied as the matrix in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) of an aggressive brain tumor tissue (glioblastoma multiforme). Ionic maps of lactate, 2-hydroxyglutarate and chloride anions (m/z 89, 147, 35, respectively) were obtained using a routine MALDI ToF mas...

M Giampà, M B Lissel, T Patschkowski, J Fuchser, V H Hans, O Gembruch, H Bednarz, K Niehaus (2016) Chemical communications (Cambridge, England) 52: 63 9801-9804

Revised version of quality guidelines for presurgical epilepsy evaluation and surgical epilepsy therapy issued by the Austrian, German, and Swiss working group on presurgical epilepsy diagnosis and operative epilepsy treatment.

2018-03-04T21:32:36Z

The definition of minimal standards remains pivotal as a basis for a high standard of care and as a basis for staff allocation or reimbursement. Only limited publications are available regarding the required staffing or methodologic expertise in epilepsy centers. The executive board of the working group (WG) on presurgical epilepsy diagnosis and operative epilepsy treatment published the first gui...

Felix Rosenow, Thomas Bast, Thomas Czech, Martha Feucht, Volkmar H Hans, Christoph Helmstaedter, Hans-Jürgen Huppertz, Soheyl Noachtar, Frank Oltmanns, Tilman Polster, Margitta Seeck, Eugen Trinka, Kathrin Wagner, Adam Strzelczyk (2016) Epilepsia 57: 8 1215-1220

Erfolgreiche Epilepsiechirurgie bei seit über 20 Jahren therapierefraktärer Temporallappenepilepsie und multiplen Voreingriffen.

2016-10-14T10:25:18Z

Epilepsie ist eine der häufigsten chronischen neurologischen Erkrankungen und stellt für die Betroffenen und Angehörigen eine erhebliche Belastung dar. Wir berichten über einen Patienten, bei dem trotz über 20 Jahren dauernden therapierefraktärem Verlauf und multiplen Voreingriffen eine langjährige Anfallsfreiheit durch einen epilepsiechirurgischen Eingriff erreicht werden konnte. Der Fallb...

Hannah Brazel, Philipp S. Reif, Sebastian Bauer, Anke Hermsen, Axel Pagenstecher, Volkmar H. Hans, Ulrich Sure, Susanne Knake, Felix Rosenow, Adam Strzelczyk (2016) Zeitschrift für Epileptologie 29: 3 156-160

Histological criteria for atypical pituitary adenomas - data from the German pituitary adenoma registry suggests modifications.

2016-08-08T08:18:44Z

The term atypical pituitary adenoma (APA) was revised in the 2004 World Health Organization (WHO) classification of pituitary tumors. However, two of the four parameters required for the diagnosis of APAs were formulated rather vaguely (i.e., "extensive" nuclear staining for p53; "elevated" mitotic index). Based on a case-control study using a representative cohort of typical pituitary adenomas an...

Christian P Miermeister, Stephan Petersenn, Michael Buchfelder, Rudolf Fahlbusch, Dieter K Lüdecke, Annett Hölsken, Markus Bergmann, Hans Ulrich Knappe, Volkmar H Hans, Jörg Flitsch, Wolfgang Saeger, Rolf Buslei (2015) Acta neuropathologica communications 3: 1

Giant Dural Supratentorial Chondroma Generating the Question of How Large Can a Tumor Become Without Revealing Itself.

2016-04-11T10:31:39Z

Chondromas usually affect the small bones of hand and feet and account for only 0.5% of all intracranial tumors. We present a case of a giant, supratentorial meningeal chondroma in a 19-year old male patient and discuss the preoperative diagnostic findings as well as the appropriate treatment options. A 19-old male presented with headache, new onset of focal seizures and paresis of left upper extr...

Alexandros Doukas, Annamarie Tallo, Richard Parvin, Volkmar Hans, Pooya Daemi, Azad Cheko, Martin Scholz, Athanasios K Petridis (2015) Clinics and practice 5: 4

Qualitätsleitlinien für prächirurgische Epilepsiediagnostik und operative Epilepsietherapie. 1. Neufassung

2016-01-26T17:48:49Z

In patients with pharmacorefractory epilepsy, preoperative epilepsy evaluation and subsequent epilepsy surgery lead to a significant improvement of seizure control, proportion of seizure-free patients, quality of life and social participation. The aims of preoperative epilepsy evaluation are to define the chance of complete seizure freedom and the likelihood of inducing new neurological deficits i...

F Rosenow, T Bast, T Czech, V Hans, C Helmstaedter, H-J Huppertz, M Seeck, E Trinka, K Wagner, Vorstand der Arbeitsgemeinschaft für prächirurgische Epilepsiediagnostik und operative Epilepsietherapie (2014) Der Nervenarzt 85: 6 753-756

SMARCB1 involvement in the development of leiomyoma in a patient with schwannomatosis.

2014-08-23T10:00:42Z

Germline SMARCB1 mutations predispose in schwannomatosis patients to the development of multiple benign schwannomas and, in some cases, meningiomas. Here, we report on a 34-year-old female patient who developed multiple schwannomas at various locations and in addition a leiomyoma of the cervix uteri. She carried a c.362+1G>A mutation that inactivates the donor splice site of exon 3. This mutation ...

Theo J M Hulsebos, Susan Kenter, Ulrike Siebers-Renelt, Volkmar Hans, Pieter Wesseling, Uta Flucke (2014) The American journal of surgical pathology 38: 3 421-425

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma.

2014-03-20T20:59:25Z

Neuroectodermal tumors in general demonstrate high and dense expression of the somatostatin receptor subtype 2 (sst₂). It controls proliferation of both normal and neoplastic cells. sst₂ has thus been suggested as a therapeutic target and prognostic marker for certain malignancies.

Marc Remke, Esther Hering, Nicolas U Gerber, Marcel Kool, Dominik Sturm, Christian H Rickert, Joachim Gerß, Stefan Schulz, Thomas Hielscher, Martin Hasselblatt, Astrid Jeibmann, Volkmar Hans, Vijay Ramaswamy, Michael D Taylor, Torsten Pietsch, Stefan Rutkowski, Andrey Korshunov, Carmelia-Maria Monoranu, Michael C Frühwald (2013) Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 29: 8 1253-1262

Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYC(low)BCL2 (low) subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas.

2015-08-25T07:31:42Z

Anna Brunn, Inga Nagel, Manuel Montesinos-Rongen, Wolfram Klapper, Inga Vater, Werner Paulus, Volkmar Hans, Ingmar Blümcke, Joachim Weis, Reiner Siebert, Martina Deckert (2013) Acta neuropathologica 126: 4 603-605

Dissecting the genomic complexity underlying medulloblastoma.

2012-09-11T09:16:19Z

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduc...

David T W Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J Pugh, Volker Hovestadt, Adrian M Stütz, Tobias Rausch, Hans-Jörg Warnatz, Marina Ryzhova, Sebastian Bender, Dominik Sturm, Sabrina Pleier, Huriye Cin, Elke Pfaff, Laura Sieber, Andrea Wittmann, Marc Remke, Hendrik Witt, Sonja Hutter, Theophilos Tzaridis, Joachim Weischenfeldt, Benjamin Raeder, Meryem Avci, Vyacheslav Amstislavskiy, Marc Zapatka, Ursula D Weber, Qi Wang, Bärbel Lasitschka, Cynthia C Bartholomae, Manfred Schmidt, Christof von Kalle, Volker Ast, Chris Lawerenz, Jürgen Eils, Rolf Kabbe, Vladimir Benes, Peter van Sluis, Jan Koster, Richard Volckmann, David Shih, Matthew J Betts, Robert B Russell, Simona Coco, Gian Paolo Tonini, Ulrich Schüller, Volkmar Hans, Norbert Graf, Yoo-Jin Kim, Camelia Monoranu, Wolfgang Roggendorf, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E Kulozik, Andreas von Deimling, Olaf Witt, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U Schuhmann, Michael C Frühwald, Martin Hasselblatt, Nada Jabado, Stefan Rutkowski, André O von Bueren, Dan Williamson, Steven C Clifford, Martin G McCabe, V Peter Collins, Stephan Wolf, Stefan Wiemann, Hans Lehrach, Benedikt Brors, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Paul A Northcott, Michael D Taylor, Matthew Meyerson, Scott L Pomeroy, Marie-Laure Yaspo, Jan O Korbel, Andrey Korshunov, Roland Eils, Stefan M Pfister, Peter Lichter (2012) Nature 488: 7409 100-105

Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias.

2012-10-29T12:43:57Z

An International League Against Epilepsy (ILAE) consensus classification system for focal cortical dysplasias (FCDs) has been published in 2011 specifying clinicopathologic FCD variants. The aim of the present work was to microscopically assess interobserver agreement and intraobserver reproducibility for FCD categories among an international group of neuropathologists with different levels of exp...

Roland Coras, Onno J de Boer, Dawna Armstrong, Albert Becker, Thomas S Jacques, Hajime Miyata, Maria Thom, Harry V Vinters, Roberto Spreafico, Buge Oz, Gianluca Marucci, Jose Pimentel, Angelika Mühlebner, Josef Zamecnik, Anna Maria Buccoliero, Fabio Rogerio, Nathalie Streichenberger, Nobutaka Arai, Marianna Bugiani, Silke Vogelgesang, Rob Macaulay, Carolin Salon, Volkmar Hans, Marc Polivka, Felice Giangaspero, Dyah Fauziah, Jang-Hee Kim, Lei Liu, Wang Dandan, Jing Gao, Benjamin Lindeboom, Ingmar Blümcke, Eleonora Aronica (2012) Epilepsia 53: 8 1341-1348

KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.

2012-06-13T05:58:45Z

In a strategy to identify novel genes involved in glioma pathogenesis by molecular characterization of chromosomal translocation breakpoints, we identified the KIAA1797 gene, encoding a protein with an as yet undefined function, to be disrupted by a 7;9 translocation in a primary glioblastoma culture. Array-based comparative genomic hybridization detected deletions involving KIAA1797 in around hal...

Antje Brockschmidt, Detlef Trost, Heike Peterziel, Katrin Zimmermann, Marion Ehrler, Henriette Grassmann, Philipp-Niclas Pfenning, Anke Waha, Dirk Wohlleber, Felix F Brockschmidt, Manfred Jugold, Alexander Hoischen, Claudia Kalla, Andreas Waha, Gerald Seifert, Percy A Knolle, Eicke Latz, Volkmar H Hans, Wolfgang Wick, Alexander Pfeifer, Peter Angel, Ruthild G Weber (2012) Brain 135: Pt 4 1027-1041

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

2012-03-21T08:41:01Z

Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation...

Tobias Rausch, David T W Jones, Marc Zapatka, Adrian M Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A Northcott, Elke Pfaff, Jelena Tica, Qi Wang, Luca Massimi, Hendrik Witt, Sebastian Bender, Sabrina Pleier, Huriye Cin, Cynthia Hawkins, Christian Beck, Andreas von Deimling, Volkmar Hans, Benedikt Brors, Roland Eils, Wolfram Scheurlen, Jonathon Blake, Vladimir Benes, Andreas E Kulozik, Olaf Witt, Dianna Martin, Cindy Zhang, Rinnat Porat, Diana M Merino, Jonathan Wasserman, Nada Jabado, Adam Fontebasso, Lars Bullinger, Frank G Rücker, Konstanze Döhner, Hartmut Döhner, Jan Koster, Jan J Molenaar, Rogier Versteeg, Marcel Kool, Uri Tabori, David Malkin, Andrey Korshunov, Michael D Taylor, Peter Lichter, Stefan M Pfister, Jan O Korbel (2012) Cell 148: 1-2 59-71

Prä- und Perinatalschäden.

2012-08-07T15:17:05Z

Volkmar H J Hans (2012) Neuropathologie. 97-116

Toll-like receptors promote inflammation in idiopathic inflammatory myopathies.

2013-01-23T13:11:03Z

The roles of Toll-like receptors (TLRs) and their myeloid differentiation response gene 88 (MyD88)-dependent and MyD88-independent signaling cascade particularly with regard to the pathogenesis and regulation of immune responses in idiopathic inflammatory myopathies are unclear. We investigated these pathways in muscle biopsies from 5 cases each of polymyositis, inclusion body myositis, dermatomyo...

Anna Brunn, Katja Zornbach, Volkmar H Hans, Walter F Haupt, Martina Deckert (2012) J Neuropathol Exp Neurol 71: 10 855-867

Multireceptor analysis in human neocortex reveals complex alterations of receptor ligand binding in focal epilepsies.

2013-04-01T11:57:33Z

A disturbed balance between excitatory and inhibitory neurotransmission underlies epileptic activity, although reports concerning neurotransmitter systems involved remain controversial.

Nicola Palomero-Gallagher, Axel Schleicher, Hans-J Bidmon, Heinz-W Pannek, Volkmar Hans, Ali Gorji, Erwin-J Speckmann, Karl Zilles (2012) Epilepsia 53: 11 1987-1997

Interictal-like network activity and receptor expression in the epileptic human lateral amygdala.

2012-03-21T08:41:01Z

While the amygdala is considered to play a critical role in temporal lobe epilepsy, conclusions on underlying pathophysiological mechanisms have been derived largely from experimental animal studies. Therefore, the present study aimed to characterize synaptic network interactions, focusing on spontaneous interictal-like activity, and the expression profile of transmitter receptors in the human lat...

Stéphanie Graebenitz, Olga Kedo, Erwin-Josef Speckmann, Ali Gorji, Heinz Panneck, Volkmar Hans, Nicola Palomero-Gallagher, Axel Schleicher, Karl Zilles, Hans-Christian Pape (2011) Brain 134: Pt 10 2929-2947

Absence of chromosome 19q13.41 amplification in a case of atypical teratoid/rhabdoid tumor with ependymoblastic differentiation.

2012-03-21T08:41:01Z

Marco Gessi, Stefan Pfister, Volkmar H Hans, Andrey Korshunov, Torsten Pietsch (2011) Acta Neuropathol 121: 2 283-285

The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene.

2012-03-21T08:41:01Z

Neutral lipid storage disease is caused by mutations in the CGI-58 or the PNPLA2 genes. Lipid storage can be detected in various cell types including blood granulocytes. While CGI-58 mutations are associated with Chanarin-Dorfman syndrome, a condition characterized by lipid storage and skin involvement (ichthyosis), mutations in the patatin-like phospholipase domain-containing protein 2 gene (PNPL...

Peter Reilich, Rita Horvath, Sabine Krause, Nicolai Schramm, Doug M Turnbull, Michael Trenell, Kieren G Hollingsworth, Grainne S Gorman, Volkmar H Hans, Jens Reimann, Andrée MacMillan, Lesley Turner, Annette Schollen, Gregor Witte, Birgit Czermin, Elke Holinski-Feder, Maggie C Walter, Benedikt Schoser, Hanns Lochmüller (2011) J Neurol 258: 11 1987-1997

Bevacizumab-induced regression of anaplastic meningioma.

2012-03-21T08:41:01Z

M J A Puchner, V H Hans, A Harati, F Lohmann, M Glas, U Herrlinger (2010) Ann Oncol 21: 12 2445-2446

Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors.

2012-03-21T08:41:01Z

Cerebral 3α-hydroxysteroid dehydrogenase (3α-HSD) activity was suggested to be responsible for the local directed formation of neuroactive 5α,3α-tetrahydrosteroids (5α,3α-THSs) from 5α-dihydrosteroids. We show for the first time that within human brain tissue 5α-dihydroprogesterone and 5α-dihydrotestosterone are converted via non-stereo-selective 3-ketosteroid reductase activity to produc...

Stephan Steckelbroeck, Dieter Lütjohann, David R Bauman, Michael Ludwig, Anke Friedl, Volkmar H J Hans, Trevor M Penning, Dietrich Klingmüller (2010) Biochim Biophys Acta 1801: 11 1221-1231

A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas.

2010-04-30T08:18:49Z

Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants. Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain. Herein, we characterized the ...

Stefanie Burghaus, Annett Hölsken, Michael Buchfelder, Rudolf Fahlbusch, Beat M Riederer, Volkmar Hans, Ingmar Blümcke, Rolf Buslei (2010) Virchows Arch 456: 3 287-300

Sublobar dysplasia--A clinicopathologic report after successful epilepsy surgery.

2010-04-30T08:18:49Z

We report the clinical presentation, neuroradiologic characteristics, and detailed histopathologic findings in a unique case of drug-resistant focal epilepsy due to sublobar dysplasia (SLD), treated successfully by resection of the malformed cortex. Histopathology with leptomeningeal and subcortical heterotopia, disturbance of cortical lamination and marked cortical and subcortical astrocytosis, b...

Ingrid Tuxhorn, Friedrich G Woermann, Heinz W Pannek, Volkmar H Hans (2009) Epilepsia 50: 12 2652-2657

Schwannomatosis.

2010-04-30T08:18:49Z

Volkmar H Hans, Alexey Surov, Malte Kornhuber, Curd Behrmann (2009) Neurology 72: 13 1188; author reply 1188-1188; author reply 1189

Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas.

2010-04-30T08:18:49Z

Activating beta-catenin (CTNNB1) mutations can be identified in the majority of adamantinomatous craniopharyngiomas (adaCP), suggesting an aberrant Wnt signaling pathway in this histopathologically peculiar tumor entity. However, there is no proven evidence that nuclear translocation of beta-catenin is associated with CTNNB1 mutations and target gene activation. We performed a laser-microdissectio...

Annett Hölsken, Jürgen Kreutzer, Bernd M Hofmann, Volkmar Hans, Falk Oppel, Michael Buchfelder, Rudolf Fahlbusch, Ingmar Blümcke, Rolf Buslei (2009) Brain Pathol 19: 3 357-364

Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma.

2010-04-30T08:18:49Z

Forkhead box P1 (FOXP1) protein is a transcription factor involved in cell signaling and regulation of gene expression. The overexpression of FOXP1 in a subgroup of systemic diffuse large B-cell lymphomas has been associated with an exceptionally poor clinical outcome. Data on FOXP1 expression in primary central nervous system lymphomas (PCNSL), that is, diffuse large B-cell lymphomas confined to ...

Cornelius Courts, Anna Brunn, Manuel Montesinos-Rongen, Dörte Siemer, Volkmar Hans, Werner Paulus, Otmar D Wiestler, Ralf Küppers, Reiner Siebert, Martina Deckert (2009) J Neuropathol Exp Neurol 68: 9 972-976

Inflammatory myopathy with abundant macrophages and dermatomyositis: two stages of one disorder or two distinct entities?

2012-01-25T09:58:45Z

Inflammatory myopathy with abundant macrophages (IMAM) and dermatomyositis (DM) are considered to represent related disorders, since they share inflammatory infiltrates and skin alterations. In order to get more insight into these disorders, we addressed the cellular composition of the inflammatory infiltrates in muscle biopsies of 11 patients with IMAM and DM. In IMAM, inflammatory infiltrates pr...

Anna Brunn, Volkmar J Hans, Silke Vogelgesang, Martina Deckert (2009) Acta Neuropathol 118: 6 793-801

Zentrales Nervensystem.

2012-08-07T15:44:14Z

Adriano Aguzzi, Markus Glatzel, Markus Tolnay, Volkmar Hans, Otmar D. Wiestler (2008) Pathologie. 255-330

Focal chronic inflammatory epileptic encephalopathy - comment on Rhodes et al.

2009-03-25T07:14:54Z

Volkmar H Hans, Rafael Villagrán (2008) Epilepsia 49: 1 180-181

Perineurial cells filled with collagen in 'atypical' Cogan's syndrome.

2009-03-25T07:14:54Z

Cogan's syndrome is a rare clinical entity characterized by non-infectious interstitial keratitis with vestibuloauditory dysfunction. The clinical course is extremely variable. In the majority of patients, there appears to be an underlying systemic process, often a "vasculitis". We were able to study for the first time a sural nerve biopsy of a 38-year-old female with clinically suggested Cogan's ...

Kay W Nolte, Volkmar J Hans, Christoph Schattenfroh, Joachim Weis, J Michael Schröder (2008) Acta Neuropathol 115: 5 589-596

Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma.

2009-03-25T07:14:54Z

Primary lymphomas of the CNS (PCNSLs) show molecular features of the late germinal center exit B-cell phenotype and are impaired in their terminal differentiation as indicated by a lack of immunoglobulin class switching. Because the positive regulatory domain I protein with ZNF domain (PRDM1/BLIMP1) is a master regulator of terminal B-cell differentiation into plasma cells, we investigated a serie...

Cornelius Courts, Manuel Montesinos-Rongen, Anna Brunn, Stefanie Bug, Dörte Siemer, Volkmar Hans, Ingmar Blümcke, Wolfram Klapper, Carlo Schaller, Otmar D Wiestler, Ralf Küppers, Reiner Siebert, Martina Deckert (2008) J Neuropathol Exp Neurol 67: 7 720-727

A method for linking computed image features to histological semantics in neuropathology.

2008-02-01T13:12:24Z

In medical image analysis the image content is often represented by features computed from the pixel matrix in order to support the development of improved clinical diagnosis systems. These features need to be interpreted and understood at a clinical level of understanding Many features are of abstract nature, as for instance features derived from a wavelet transform. The interpretation and analys...

B Lessmann, T W Nattkemper, V H Hans, A Degenhard (2007) J Biomed Inform 40: 6 631-641

Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas.

2007-12-10T10:57:41Z

Activation of the Wnt/wingless signalling cascade is a key mechanism in developmental morphogenesis, whereas aberrant nuclear accumulation of beta-catenin in adult tissues seems to be associated with neoplastic transformation and tumour progression. Adamantinomatous craniopharyngiomas carry activating mutations in exon 3 of the beta-catenin gene, which results in a distinct pattern of nuclear beta...

Rolf Buslei, Annett Hölsken, Bernd Hofmann, Jürgen Kreutzer, Florian Siebzehnrubl, Volkmar Hans, Falk Oppel, Michael Buchfelder, Rudolf Fahlbusch, Ingmar Blümcke (2007) Acta Neuropathol 113: 5 585-590

The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene.

2007-12-10T10:57:41Z

Coenzyme Q10 (CoQ10) deficiency is an autosomal recessive disorder with heterogenous phenotypic manifestations and genetic background. We describe seven patients from five independent families with an isolated myopathic phenotype of CoQ10 deficiency. The clinical, histological and biochemical presentation of our patients was very homogenous. All patients presented with exercise intolerance, fatigu...

Klaus Gempel, Haluk Topaloglu, Beril Talim, Peter Schneiderat, Benedikt G H Schoser, Volkmar H Hans, Beatrix Pálmafy, Gulsev Kale, Aysegul Tokatli, Catarina Quinzii, Michio Hirano, Ali Naini, Salvatore DiMauro, Holger Prokisch, Hanns Lochmüller, Rita Horvath (2007) Brain 130: Pt 8 2037-2044

Astrocytes are a specific immunological target in Rasmussen's encephalitis.

2007-12-10T10:57:41Z

OBJECTIVE: The current histopathological criteria of Rasmussen's encephalitis (RE) include the presence of T-cell-dominated inflammation, microglial activation, neuronal loss, and astrocytic activation. An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ. METHODS: Histochemical, immun...

Jan Bauer, Christian E Elger, Volkmar H Hans, Johannes Schramm, Horst Urbach, Hans Lassmann, Christian G Bien (2007) Ann Neurol 62: 1 67-80

Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases.

2008-02-01T13:12:24Z

Angiocentric glioma has recently been described as a novel epilepsy associated tumor with distinct clinico-pathologic features. We report the clinical and pathologic findings in 8 additional cases of this rare tumor type and extend its characterization by genomic profiling. Almost all patients had a history of long-standing drug-resistant epilepsy. Cortico-subcortical tumors were located in the te...

Matthias Preusser, Alexander Hoischen, Klaus Novak, Thomas Czech, Daniela Prayer, Johannes A Hainfellner, Christoph Baumgartner, Friedrich G Woermann, Ingrid E Tuxhorn, Heinz W Pannek, Markus Bergmann, Bernhard Radlwimmer, Rafael Villagrán, Ruthild G Weber, Volkmar H Hans (2007) Am J Surg Pathol 31: 11 1709-1718

Normal brain development in importin-alpha5 deficient-mice.

2009-03-25T07:14:54Z

Tatjana Shmidt, Franziska Hampich, Michael Ridders, Stefanie Schultrich, Volkmar H Hans, Katja Tenner, Larissa Vilianovich, Fatimunnisa Qadri, Natalia Alenina, Enno Hartmann, Matthias Köhler, Michael Bader (2007) Nat Cell Biol 9: 12 1337-8; author reply 1339

Angiocentric giloma.

2012-08-08T08:59:08Z

Burger PC, Jouvet A, Preusser M, Hans VH, Rosenblum MK, Lellouch-Tubiana A (2007) WHO Classification of Tumours of the Central Nervous System. 92-93

Prognostic implications of atypical histologic features in choroid plexus papilloma.

2007-12-10T10:57:41Z

The prognostic significance of atypical histologic features in choroid plexus tumors remains uncertain. Therefore, a series of 164 choroid plexus tumors was evaluated for the presence of atypical histologic features, including mitotic activity, increased cellularity, nuclear pleomorphism, blurring of papillary growth pattern, and necrosis. The impact of histopathologic and clinical features on the...

Astrid Jeibmann, Martin Hasselblatt, Joachim Gerss, Brigitte Wrede, Rupert Egensperger, Rudi Beschorner, Volkmar H J Hans, Christian H Rickert, Johannes E Wolff, Werner Paulus (2006) J Neuropathol Exp Neurol 65: 11 1069-1073

Primary hypophysitis: clinical-pathological correlations.

2007-12-10T10:57:41Z

OBJECTIVE: Primary hypophysitis comprises of three distinct histomorphological entities: lymphocytic, granulomatous and xanthomatous. Clinical features of the three subtypes for diagnostic and treatment strategies have yet not been well characterized. METHODS: Endocrine function, visual fields and acuity as well as magnetic resonance imaging characteristics were assessed before and after transphen...

Angelika Gutenberg, Volkmar Hans, Maximilian J A Puchner, Jürgen Kreutzer, Wolfgang Brück, Patrizio Caturegli, Michael Buchfelder (2006) Eur J Endocrinol 155: 1 101-107

Molecular neuropathology of epilepsy-associated glioneuronal malformations.

2007-12-10T10:57:41Z

Glioneuronal malformations (malformations of cortical development [MCD]) include focal cortical dysplasias (FCD) as well as highly differentiated glioneuronal tumors (i.e. gangliogliomas) and constitute frequent findings in patients with pharmacoresistent focal epilepsies. Tailored resection strategies evolved as promising treatment options and allow a systematic neuropathologic and molecular biol...

Albert J Becker, Ingmar Blümcke, Horst Urbach, Volkmar Hans, Michael Majores (2006) J Neuropathol Exp Neurol 65: 2 99-108

Long-term relapse-free survival with supratentorial primitive neuroectodermal tumor in an adult: a case report.

2007-12-10T10:57:41Z

OBJECTIVE: In adults, supratentorial primitive neuroectodermal tumor (sPNET) is a very rare undifferentiated embryoblastic neoplasm. Prognosis is worse in comparison to infratentorial medulloblastoma. Older age appears to be prognostically favorable. At present, 5-year survival rates remain below 50% in all age groups. Survival longer than 15 years in an adult has only been reported once so far. C...

Thomas Krampulz, Volkmar H Hans, Falk Oppel, Uwe Dietrich, Maximilian J A Puchner (2006) J Neurooncol 77: 3 291-294

Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination.

2007-12-10T10:57:41Z

Primary central nervous system lymphomas (PCNSLs) are diffuse large B cell lymphomas confined to the brain. Only minimal data exist on chromosomal aberrations underlying PCNSLs. We studied 41 PCNSLs by fluorescence in situ hybridization for breakpoints affecting the BCL6 locus in chromosomal band 3q27. Of 37 cases evaluable, 14 (38%) carried a breakpoint in the BCL6 locus. Two of these showed juxt...

Heinrich Schwindt, Takashi Akasaka, Reina Zühlke-Jenisch, Volkmar Hans, Carlo Schaller, Wolfram Klapper, Martin J S Dyer, Reiner Siebert, Martina Deckert (2006) J Neuropathol Exp Neurol 65: 8 776-782

Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells.

2007-12-10T10:57:41Z

Epilepsy-associated malformations of cortical development (MCDs) comprise a variety of dysplastic and neoplastic lesions of yet undetermined molecular pathology. Histopathologic similarities between MCDs and dysplastic brain lesions in the autosomal inherited neurocutaneous phacomatosis tuberous sclerosis (TSC), which affects the TSC1 and/or TSC2 genes, suggest common pathogenetic mechanisms. Prev...

Michael Majores, Ingmar Blümcke, Horst Urbach, Alessandra Meroni, Volkmar Hans, Hans Holthausen, Christian E Elger, Johannes Schramm, Carlo Galli, Roberto Spreafico, Otmar D Wiestler, Albert J Becker (2005) J Neuropathol Exp Neurol 64: 7 629-637

Mutant valosin-containing protein causes a novel type of frontotemporal dementia.

2007-12-10T10:57:41Z

Mutations in the valosin-containing protein (VCP) gene on chromosome 9p13-p12 recently have been shown to cause autosomal dominant inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. Here, we report the central nervous system autopsy findings in a 55-year-old German patient with inclusion body myopathy and frontotemporal dementia who harbors a heterozyg...

Rolf Schröder, Giles D J Watts, Sarju G Mehta, Bernd O Evert, Petra Broich, Klaus Fliessbach, Katharina Pauls, Volkmar H Hans, Virginia Kimonis, Dietmar R Thal (2005) Ann Neurol 57: 3 457-461

Recurrent glomus tumor of the sellar region with malignant progression.

2007-12-10T10:57:41Z

Daniel Hänggi, Heiner Adams, Volkmar H Hans, Alphonse Probst, Markus Tolnay (2005) Acta Neuropathol 110: 1 93-96

O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS).

2007-12-10T10:57:41Z

Mammalian neurofilaments (NFs) are modified by post-translational modifications that are thought to regulate NF assembly and organization. Whereas phosphorylation has been intensely studied, the role of another common modification, the attachment of O-linked N-acetylglucosamine (GlcNAc) to individual serine and threonine residues, is hardly understood. We generated a novel monoclonal antibody that...

Nina Lüdemann, Albrecht Clement, Volkmar H Hans, Julia Leschik, Christian Behl, Roland Brandt (2005) J Biol Chem 280: 36 31648-31658

Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study.

2007-12-10T10:57:41Z

Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are suggested to be important neurosteroids. We investigated steroid sulfatase (STS) in human temporal lobe biopsies in the context of possible cerebral DHEA(S) de novo biosynthesis. Formation of DHEA(S) in mature human brain tissue has not yet been studied. 17 alpha-Hydroxylase/C17-20-lyase and hydroxysteroid sulfotransferase catalyze the form...

Stephan Steckelbroeck, Alexander Nassen, Bernhard Ugele, Michael Ludwig, Matthias Watzka, Annette Reissinger, Hans Clusmann, Dieter Lütjohann, Lothar Siekmann, Dietrich Klingmüller, Volkmar H Hans (2004) J Neurochem 89: 2 403-417

Rasmussen encephalitis with active inflammation and delayed seizures onset.

2007-12-10T10:57:41Z

Severe focal epilepsy is regarded as a clinical hallmark of Rasmussen encephalitis (RE). The authors report two children with progressive hemiparesis, contralateral hemispheric atrophy, and pathologic features characteristic for RE. At histologic diagnosis and over several months, neither patient experienced seizures. The report enlarges the clinical spectrum of RE and suggests that seizures are n...

I Korn-Lubetzki, C G Bien, J Bauer, M Gomori, H Wiendl, L Trajo, H Ovadia, B Wilken, V H Hans, C E Elger, H Hurvitz, I Steiner (2004) Neurology 62: 6 984-986

Associations between polymorphisms in the thymidylate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer.

2007-12-10T10:57:41Z

Microsatellite instability (MSI) is a characteristic feature of up to 15% of colorectal cancers (CRC) and is associated with better response to adjuvant chemotherapy with 5-fluorouracil (5-FU). In this study we have investigated the association between the MSI status and the mRNA expression as well as the polymorphisms of the cellular target of 5-FU therapy, thymidylate synthase. Polymorphisms in ...

Sabine Merkelbach-Bruse, Volkmar Hans, Micaela Mathiak, Rosario Sanguedolce, Riccardo Alessandro, Josef Rüschoff, Reinhard Büttner, Farzad Houshdaran, Lucia Gullotti (2004) Oncol Rep 11: 4 839-843

Entwicklungsstörungen und Fehlbildungen.

2012-08-08T08:59:23Z

Volkmar H Hans, Otmar D Wiestler (2004) Pathologie. 268-273

Transition from meningeal melanocytoma to primary cerebral melanoma. Case report.

2007-12-10T10:57:41Z

The authors describe the first case of an intracranial transition of a melanocytoma into a primary malignant melanoma within a short time. A 37-year-old woman presented with progressive brainstem syndrome due to a tumor, originally diagnosed and treated 12 years earlier, that extended from the petroclival area to the anterior craniocervical junction. The histological workup following subtotal tumo...

Florian Roser, Makoto Nakamura, Almuth Brandis, Volkmar Hans, Peter Vorkapic, Madjid Samii (2004) J Neurosurg 101: 3 528-531

Intraventricular cytarabine in a case of idiopathic hypertrophic pachymeningitis.

2007-12-10T10:57:41Z

Idiopathic hypertrophic chronic pachymeningitis (IHCP) is characterised by inflammatory fibrotic thickening of the dura mater. Long term management is controversial. A 28 year old man with craniospinal IHCP and prominent lymphocytic meningitis is reported. Cerebrospinal fluid and histological examination suggested a CD4+ T cell driven process and B cell stimulation. After surgical, tuberculostatic...

I Kleiter, V H Hans, G Schuierer, J Marienhagen, P Hau, H Schütz, U Bogdahn, A Steinbrecher (2004) J Neurol Neurosurg Psychiatry 75: 9 1346-1348

Schädel-Hirn-Trauma.

2012-08-08T08:59:35Z

Volkmar H Hans, Otmar D Wiestler (2004) Pathologie. 273-279

Zytokinfreisetzung nach Schädel-Hirn-Verletzungen -- Klinische und experimentelle Resultate

2013-11-04T12:59:14Z

Volkmar H J Hans (2004) Rheinische Friedrich-Wilhelms-Universität Bonn

Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins.

2007-12-10T10:57:41Z

Malignant gliomas are the most frequent primary brain tumors and have a dismal prognosis due to their infiltrative growth. Gene therapy using viral vectors represents an attractive alternative to conventional cancer therapies. In a previous study, we established lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus (LCMV) glycoproteins (GPs) and demonstrated transduction of human ...

Hrvoje Miletic, Yvonne Heidemarie Fischer, Harald Neumann, Volkmar Hans, Werner Stenzel, Tsanan Giroglou, Manuel Hermann, Martina Deckert, Dorothee Von Laer (2004) Hum Gene Ther 15: 11 1091-1100

Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors.

2007-12-10T10:57:41Z

Gastrointestinal stromal tumors (GISTs) typically express high levels of the Kit-receptor. The majority of GISTs carry mutations in the c-kit protooncogene clustering in exon 11. The significance of c-kit mutations for the biological behavior of GISTs is still under discussion. We evaluated 55 sporadic GISTs with available follow-up data for c-kit mutations in the juxtamembrane domain and detected...

Eva Wardelmann, Inge Losen, Volkmar Hans, Iris Neidt, Nicola Speidel, Erhard Bierhoff, Thomas Heinicke, Torsten Pietsch, Reinhard Büttner, Sabine Merkelbach-Bruse (2003) Int J Cancer 106: 6 887-895

Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain.

2007-12-10T10:57:41Z

Estrogens play a crucial role in multiple functions of the brain and the proper balance of inactive estrone and active estradiol-17beta might be very important for their cerebral effects. The interconversion of estrone and estradiol-17beta in target tissues is known to be catalysed by a number of human 17beta-hydroxysteroid dehydrogenase (17beta-HSD) isoforms. The present study shows that enzyme c...

Stephan Steckelbroeck, Matthias Watzka, Annette Reissinger, Petra Wegener-Toper, Frank Bidlingmaier, Niklaas Bliesener, Volkmar H J Hans, Hans Clusmann, Michael Ludwig, Lothar Siekmann, Dietrich Klingmüller (2003) J Steroid Biochem Mol Biol 86: 1 79-92

The regional oxygen saturation of pituitary adenomas is lower than that of the pituitary gland: microspectrophotometric study with potential clinical implications.

2007-12-10T10:57:41Z

OBJECTIVE: To study the regional oxygen saturation (rSO(2)) of pituitary adenomas, in comparison with that of the pituitary gland. METHODS: Microspectrophotometric (MSP) measurements of rSO(2) in adenomas and pituitary tissue were performed for a series of patients undergoing first-time transsphenoidal pituitary adenoma surgery, in a standardized anesthesia setting. The areas of measured tissue we...

Rudolf A Kristof, Ales F Aliashkevich, Volkmar Hans, Dorothee Haun, Bernhard Meyer, Christoph Thees, Johannes Schramm (2003) Neurosurgery 53: 4 880-5; discussion 885-6

Pathologie und biologische Grundlagen hirneigener Tumoren.

2012-08-07T20:15:57Z

Wiestler, O.D., Becker, A., Burkhardt, R., Buslei, R., Hans, V.H.J., Pietsch, T. (2002) Klinik der hirneigenen Tumoren und Metastasen: Grundlagen-Diagnostik-Therapie. 1-26

Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression.

2007-12-10T10:57:41Z

We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16. Ectopic p16 expression led to a stable but reversible G1 phase cell cycle arrest, reduced the growth of both cell lines in cell culture, and almost abolished their in vitro tumorigenicity. U-87MG-tTA-p16 glioblastoma cells consi...

Matthias Simon, Christian Simon, Gertraud Köster, Volkmar H J Hans, Johannes Schramm (2002) J Neurooncol 60: 1 1-12

Combined surgery, radiation, and PCV chemotherapy for astrocytomas compared to oligodendrogliomas and oligoastrocytomas WHO grade III.

2007-12-10T10:57:41Z

The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocytomas (AIII), oligodendrogliomas (OIII) and oligoastrocytomas (OAIII) WHO grade III. The treatment was carried out in 48 patients: 24 AIII, 20 OAIII and four OIII, at the same medical institu...

Rudolf A Kristof, Georg Neuloh, Volkmar Hans, Martina Deckert, Horst Urbach, Uwe Schlegel, Matthias Simon, Johannes Schramm (2002) J Neurooncol 59: 3 231-237

Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7alpha-hydroxylase and 17-ketosteroid reductase activity in the human brain.

2007-12-10T10:57:41Z

Dehydroepiandrosterone and its sulphate are important factors for vitality, development and functions of the CNS. They were found to be subjects to a series of enzyme-mediated conversions within the rodent CNS. In the present study, we were able to demonstrate for the first time that membrane-associated dehydroepiandrosterone 7alpha-hydroxylase activity occurs within the human brain. The cytochrom...

Stephan Steckelbroeck, Matthias Watzka, Dieter Lütjohann, Paul Makiola, Alexander Nassen, Volkmar H J Hans, Hans Clusmann, Annette Reissinger, Michael Ludwig, Lothar Siekmann, Dietrich Klingmüller (2002) J Neurochem 83: 3 713-726

January 2002: 59-year-old woman with an intrasellar lesion.

2007-12-10T10:57:41Z

An intrasellar lesion resembling a hormone-inactive pituitary adenoma was resected in a 59-year-old woman. The well-differentiated benign tumor was composed of ganglion-like cells, clusters of adenohypophyseal tissue as well as a GH-expressing adenoma. In addition, small cells exhibited an intermediate neuronal and epithelial immunoreactivity. Surrounding the tumor was a spindle cell component tha...

Volkmar H J Hans, Horst Urbach, Rudolph A Kristof, Martina Deckert (2002) Brain Pathol 12: 3 391-2, 397

Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats.

2007-12-10T10:57:41Z

The pathophysiology of traumatic axonal injury (TAI) is only partially understood. In this study, we investigated the inflammatory response as well as the extent of neurological deficit in a rat model of traumatic brain injury (TBI). Forty-two adult rats were subjected to moderate impact-acceleration brain injury and their brains were analyzed immunohistochemically for ICAM-1 expression and neutro...

M Rancan, V I Otto, V H Hans, I Gerlach, R Jork, O Trentz, T Kossmann, M C Morganti-Kossmann (2001) J Neurosci Res 63: 5 438-446

Expression of the 17beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain.

2007-12-10T10:57:41Z

An enzyme-mediated metabolism of androgens and estrogens including 17beta-HSD activity in the brain of vertebrates was discovered approximately 30 years ago. Mainly 5alpha-reductase and aromatase have been studied in detail. Recently we could demonstrate reductive and oxidative 17beta-HSD activity as well as considerable mRNA expression of the 17beta-HSD types 3 and 4 in the human brain. In the pr...

S Steckelbroeck, M Watzka, B Stoffel-Wagner, V H Hans, L Redel, H Clusmann, C E Elger, F Bidlingmaier, D Klingmüller (2001) Mol Cell Endocrinol 171: 1-2 165-168

Chicken arachnoid granulations: a new model for cerebrospinal fluid absorption in man.

2007-12-10T10:57:41Z

Cerebrospinal fluid (CSF) absorption was investigated chicken and rat using infusion tests into the cisterna magna. Data were analysed according to a mathematical model by Johnson et al. Results in rat predicted a predominant lymphatic mechanism, which was confirmed by rapid outflow of X-ray contrast media into the olfactoric mucosa. In contrast, dynamics measurements suggested CSF drainage via ar...

U Kelkenberg, D B von Rautenfeld, T Brinker, V H Hans (2001) Neuroreport 12: 3 553-557

Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans.

2007-12-10T10:57:41Z

The brain is believed to be an immunologically privileged organ, sheltered from the systemic immunological defense by the blood-brain barrier (BBB). However, there is increasing evidence for a marked inflammatory response in the brain after traumatic brain injury (TBI). Markers for cellular immune activation, neopterin, beta2-microglobulin (beta2M), and soluble interleukin-2 receptor (sIL-2R), wer...

P M Lenzlinger, V H Hans, H I Jöller-Jemelka, O Trentz, M C Morganti-Kossmann, T Kossmann (2001) J Neurotrauma 18: 5 479-489

Human herpes virus-8 is not associated with primary central nervous system lymphoma in HIV-negative patients.

2007-12-10T10:57:41Z

Primary central nervous system lymphomas (PCNSL) are derived from germinal center B cells. Recent molecular studies indicate that the tumor cells or their precursors have experienced antigenic stimulation. Attractive candidates for such antigens are pathogens with the capacity to reside in the brain. The aim of the present study was to evaluate whether human herpes virus (HHV)-8 is involved in the...

M Montesinos-Rongen, V H Hans, A M Eis-Hübinger, M Prinz, C Schaller, D Van Roost, A Aguzzi, O D Wiestler, M Deckert (2001) Acta Neuropathol 102: 5 489-495

Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells.

2007-12-10T10:57:41Z

Microtubule-associated protein 2 (MAP2), a protein linked to the neuronal cytoskeleton in the mature central nervous system (CNS), has recently been identified in glial precursors indicating a potential role during glial development. In the present study, we systematically analyzed the expression of MAP2 in a series of 237 human neuroepithelial tumors including paraffin-embedded specimens and tumo...

I Blümcke, A J Becker, S Normann, V Hans, B M Riederer, S Krajewski, O D Wiestler, G Reifenberger (2001) J Neuropathol Exp Neurol 60: 10 984-993

Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain.

2007-12-10T10:57:41Z

Although androgen metabolism in the human brain was discovered almost 30 yr ago, conclusive studies on the enzymes involved are still lacking. We therefore investigated 5alpha-reductase and colocalized 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity in cerebral neocortex (CX) and subcortical white matter (SC) specimens neurosurgically removed from 44 patients suffering from epilepsy. We ...

S Steckelbroeck, M Watzka, R Reichelt, V H Hans, B Stoffel-Wagner, D D Heidrich, J Schramm, F Bidlingmaier, D Klingmüller (2001) J Clin Endocrinol Metab 86: 3 1324-1331

Mixed gangliocytoma/pituitary adenoma.

2007-12-10T10:57:41Z

M C Sabel, V H Hans, G Reifenberger (2000) Arch Neurol 57: 4 587-588

Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progression.

2007-12-10T10:57:41Z

OBJECT: In recent reports, 6 to 19% of meningiomas have been classified as atypical or anaplastic/malignant. Some atypical and anaplastic meningiomas appear to arise from benign tumors by progression. Telomerase activation has recently been associated with malignant progression of human tumors. The authors have investigated a series of benign, atypical, and anaplastic/malignant meningiomas for tel...

M Simon, T W Park, S Leuenroth, V H Hans, T Löning, J Schramm (2000) J Neurosurg 92: 5 832-840

Cell activation and inflammatory response following traumatic axonal injury in the rat.

2007-12-10T10:57:41Z

In a rat model of traumatic brain injury cell activation was characterized immunohistochemically from 2 h up to 2 weeks. Reactive astrocytosis became apparent perivascularly and in the grey matter within 4h after trauma. Increased OX42 immunoreactivity indicated microglial activation in cortex and hippocampus as early as 4 h, whereas up-regulation of MHC class II (OX6) was evident in white matter ...

E Csuka, V H Hans, E Ammann, O Trentz, T Kossmann, M C Morganti-Kossmann (2000) Neuroreport 11: 11 2587-2590

Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid.

2007-12-10T10:57:41Z

Diffuse axonal injury is a frequent pathologic sequel of head trauma, which, despite its devastating consequences for the patients, remains to be fully elucidated. Here we studied the release of interleukin-6 (IL-6) into CSF and serum, as well as the expression of IL-6 messenger ribonucleic acid (mRNA) and protein in a weight drop model of axonal injury in the rat. The IL-6 activity was elevated i...

V H Hans, T Kossmann, P M Lenzlinger, R Probstmeier, H G Imhof, O Trentz, M C Morganti-Kossmann (1999) J Cereb Blood Flow Metab 19: 2 184-194

Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma.

2007-12-10T10:57:41Z

Interleukin-6 (IL-6) and its soluble receptor (sIL-6-R) were measured in cerebrospinal fluid (CSF) and serum of 11 severely head injured patients for up to 3 weeks following trauma. IL-6 increased immediately after injury displaying much higher concentrations in CSF than in serum (n = 11). Differently, median levels of sIL-6-R remained in the normal ranges being 10 times higher in serum than in CS...

V H Hans, T Kossmann, H Joller, V Otto, M C Morganti-Kossmann (1999) Neuroreport 10: 2 409-412

Characterization of aromatase cytochrome P450 activity in the human temporal lobe.

2007-12-10T10:57:41Z

Local aromatase-mediated conversion of androgens plays an important role in androgen action on the brain. To characterize estrogen formation in the human brain, we measured the microsomal aromatase activity of temporal lobe biopsies and compared it to that of human placenta using a highly sensitive 3H2O assay with [1beta-3H]androstenedione as substrate. Brain tissue was removed neurosurgically fro...

S Steckelbroeck, D D Heidrich, B Stoffel-Wagner, V H Hans, J Schramm, F Bidlingmaier, D Klingmüller (1999) J Clin Endocrinol Metab 84: 8 2795-2801

TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function.

2007-12-10T10:57:41Z

Traumatic brain injury (TBI) induces local and systemic immunologic changes, release of cytokines, and cell activation. Perpetuation of these cascades may contribute to secondary damage to the brain. Therefore, the ability of the antiinflammatory mediator transforming growth factor-beta (TGF-beta) to downregulate intrathecal immunoactivation may be of fundamental value for diminishing the incidenc...

M C Morganti-Kossmann, V H Hans, P M Lenzlinger, R Dubs, E Ludwig, O Trentz, T Kossmann (1999) J Neurotrauma 16: 7 617-628

Traumatic brain injury in the developing rat pup: studies of ICP, PVI and neurological response.

2007-12-10T10:57:41Z

Diffuse brain swelling is a common complication in young victims of a seven head injury but, there is a lack of data on relevant models of injury. We produced diffuse brain injury in 21 day old Lewis rat pups (N = 33) by modifying a recently established weight-drop-model. The trauma threshold, neurological response, histological changes, intracranial pressure (ICP), and arterial blood pressure (AB...

S Thomas, F Tabibnia, M U Schuhmann, V H Hans, T Brinker, M Samii (1998) Acta Neurochir Suppl 71: 135-137

CSF dynamics in a rodent model of closed head injury.

2007-12-10T10:57:41Z

Using ICP measurements and the bolus injection technique dynamic parameters of the cerebrospinal fluid system as there are pressure-volume-index (PVI) and resistance to CSF outflow (Rout) were investigated in a new model of diffuse closed head injury (CHI) in the rat. It was found that in the absence of brain oedema and ICP alterations an increase in PVI and Rout was present in the early (4h) peri...

M U Schuhmann, S Thomas, V H Hans, H Beck, T Brinker, M Samii (1998) Acta Neurochir Suppl 71: 300-302

Experimental diffuse axonal injury induces enhanced neuronal C5a receptor mRNA expression in rats.

2007-12-10T10:57:41Z

Several studies suggest the involvement of the complement system in the pathophysiology of traumatic brain injury (TBI). Since the intrathecal generation of anaphylatoxin C5a has been shown to mediate inflammatory effects within the central nervous system, we sought to characterize the cellular expression of the mRNA for the C5a receptor (C5aR, CD88) in brains of rats with experimental diffuse axo...

P F Stahel, T Kossmann, M C Morganti-Kossmann, V H Hans, S R Barnum (1997) Brain Res Mol Brain Res 50: 1-2 205-212

Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue.

2007-12-10T10:57:41Z

A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-alpha and TGF-beta were monitored in CSF...

M C Morganti-Kossman, P M Lenzlinger, V Hans, P Stahel, E Csuka, E Ammann, R Stocker, O Trentz, T Kossmann (1997) Mol Psychiatry 2: 2 133-136

Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury.

2007-12-10T10:57:41Z

Cefuroxime levels were measured in cerebrospinal fluid (CSF) and serum of four patients with traumatic brain injury following the implantation of intraventricular catheters. The levels ranged from 0.15 to 2.03 micrograms/mL in CSF and from 1.8 to 66.9 micrograms/mL in serum. No ventriculostomy related infections were detected.

T Kossmann, V Hans, R Stocker, H G Imhof, B Joos, O Trentz, M C Morganti-Kossmann (1996) J Antimicrob Chemother 37: 1 161-167

Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes.

2007-12-10T10:57:41Z

Cytokines are involved in nerve regeneration by modulating the synthesis of neurotrophic factors. The role played by interleukin-6 (IL-6) in promoting nerve growth factor (NGF) after brain injury was investigated by monitoring the release of IL-6 and NGF in ventricular cerebrospinal fluid (CSF) of 22 patients with severe traumatic brain injuries. IL-6 was found in the CSF of all individuals and re...

T Kossmann, V Hans, H G Imhof, O Trentz, M C Morganti-Kossmann (1996) Brain Res 713: 1-2 143-152

Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries.

2007-12-10T10:57:41Z

Patients with severe traumatic brain injury (TBI) show a profound acute-phase response. Because interleukin-6 (IL-6) is an important mediator of these pathophysiological changes, IL-6 levels were monitored in the cerebrospinal fluid (CSF) and serum of 20 patients with severe isolated TBI. All patients received indwelling ventricular catheters for intracranial pressure monitoring and for release of...

T Kossmann, V H Hans, H G Imhof, R Stocker, P Grob, O Trentz, C Morganti-Kossmann (1995) Shock 4: 5 311-317

Die Bealschen Sacculi -- Eine roentgenographische und immunhistochemische Studie zur Häufung pathologischer Prozesse im Pankreaskopf

2013-11-04T12:59:59Z

Volkmar H J Hans (1994) Friedrich-Alexander-Universität Erlangen

Juxtapapillary duodenal diverticulum

2007-12-10T10:57:41Z

V H Hans, H Rupprecht (1993) Dtsch Med Wochenschr 118: 31