http://publicationslist.org/data/volkmar.hans/atom.xml Volkmar Hanshttp://publicationslist.org/volkmar.hans$basepathfavicon.icoRecent additions to Volkmar Hans's PublicationsList.org pagehttp://publicationslist.org/publications.png2012-01-25T10:14:09Z http://publicationslist.org/volkmar.hans/refid81 2012-01-25T10:13:47Z

Volkmar HJ Hans (2012) <i>Neuropathologie</i> 97-116<br/>

http://publicationslist.org/volkmar.hans/refid78 2012-01-25T09:55:06Z

Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation...<br/><br/>Tobias Rausch, David T W Jones, Marc Zapatka, Adrian M Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A Northcott, Elke Pfaff, Jelena Tica, Qi Wang, Luca Massimi, Hendrik Witt, Sebastian Bender, Sabrina Pleier, Huriye Cin, Cynthia Hawkins, Christian Beck, Andreas von Deimling, Volkmar Hans, Benedikt Brors, Roland Eils, Wolfram Scheurlen, Jonathon Blake, Vladimir Benes, Andreas E Kulozik, Olaf Witt, Dianna Martin, Cindy Zhang, Rinnat Porat, Diana M Merino, Jonathan Wasserman, Nada Jabado, Adam Fontebasso, Lars Bullinger, Frank G Rücker, Konstanze Döhner, Hartmut Döhner, Jan Koster, Jan J Molenaar, Rogier Versteeg, Marcel Kool, Uri Tabori, David Malkin, Andrey Korshunov, Michael D Taylor, Peter Lichter, Stefan M Pfister, Jan O Korbel (2012) <i>Cell</i> <i></i> <i></i> 148: 1-2 59-71<br/>

http://publicationslist.org/volkmar.hans/refid79 2012-01-25T09:55:06Z

While the amygdala is considered to play a critical role in temporal lobe epilepsy, conclusions on underlying pathophysiological mechanisms have been derived largely from experimental animal studies. Therefore, the present study aimed to characterize synaptic network interactions, focusing on spontaneous interictal-like activity, and the expression profile of transmitter receptors in the human lat...<br/><br/>Stéphanie Graebenitz, Olga Kedo, Erwin-Josef Speckmann, Ali Gorji, Heinz Panneck, Volkmar Hans, Nicola Palomero-Gallagher, Axel Schleicher, Karl Zilles, Hans-Christian Pape (2011) <i>Brain</i> <i></i> <i></i> 134: Pt 10 2929-2947<br/>

http://publicationslist.org/volkmar.hans/refid80 2012-01-25T09:55:07Z

Neutral lipid storage disease is caused by mutations in the CGI-58 or the PNPLA2 genes. Lipid storage can be detected in various cell types including blood granulocytes. While CGI-58 mutations are associated with Chanarin-Dorfman syndrome, a condition characterized by lipid storage and skin involvement (ichthyosis), mutations in the patatin-like phospholipase domain-containing protein 2 gene (PNPL...<br/><br/>Peter Reilich, Rita Horvath, Sabine Krause, Nicolai Schramm, Doug M Turnbull, Michael Trenell, Kieren G Hollingsworth, Grainne S Gorman, Volkmar H Hans, Jens Reimann, Andrée MacMillan, Lesley Turner, Annette Schollen, Gregor Witte, Birgit Czermin, Elke Holinski-Feder, Maggie C Walter, Benedikt Schoser, Hanns Lochmüller (2011) <i>J Neurol</i> <i></i> <i></i> 258: 11 1987-1997<br/>

http://publicationslist.org/volkmar.hans/refid75 2012-01-25T09:55:07Z

Marco Gessi, Stefan Pfister, Volkmar H Hans, Andrey Korshunov, Torsten Pietsch (2011) <i>Acta Neuropathol</i> <i></i> <i></i> 121: 2 283-285<br/>

http://publicationslist.org/volkmar.hans/refid77 2012-01-25T09:55:07Z

Cerebral 3α-hydroxysteroid dehydrogenase (3α-HSD) activity was suggested to be responsible for the local directed formation of neuroactive 5α,3α-tetrahydrosteroids (5α,3α-THSs) from 5α-dihydrosteroids. We show for the first time that within human brain tissue 5α-dihydroprogesterone and 5α-dihydrotestosterone are converted via non-stereo-selective 3-ketosteroid reductase activity to produc...<br/><br/>Stephan Steckelbroeck, Dieter Lütjohann, David R Bauman, Michael Ludwig, Anke Friedl, Volkmar H J Hans, Trevor M Penning, Dietrich Klingmüller (2010) <i>Biochim Biophys Acta</i> <i></i> <i></i> 1801: 11 1221-1231<br/>

http://publicationslist.org/volkmar.hans/refid76 2012-01-25T09:55:07Z

M J A Puchner, V H Hans, A Harati, F Lohmann, M Glas, U Herrlinger (2010) <i>Ann Oncol</i> <i></i> <i></i> 21: 12 2445-2446<br/>

http://publicationslist.org/volkmar.hans/refid71 2010-04-30T08:18:49Z

Craniopharyngiomas (CP) are benign epithelial tumors of the sellar region and can be clinicopathologically distinguished into adamantinomatous (adaCP) and papillary (papCP) variants. Both subtypes are classified according to the World Health Organization grade I, but their irregular digitate brain infiltration makes any complete surgical resection difficult to obtain. Herein, we characterized the ...<br/><br/>Stefanie Burghaus, Annett Hölsken, Michael Buchfelder, Rudolf Fahlbusch, Beat M Riederer, Volkmar Hans, Ingmar Blümcke, Rolf Buslei (2010) <i>Virchows Arch</i> <i></i> <i></i> 456: 3 287-300<br/>

http://publicationslist.org/volkmar.hans/refid70 2010-04-30T08:18:49Z

Volkmar H Hans, Alexey Surov, Malte Kornhuber, Curd Behrmann (2009) <i>Neurology</i> <i></i> <i></i> 72: 13 1188; author reply 1188-1188; author reply 1189<br/>

http://publicationslist.org/volkmar.hans/refid69 2010-04-30T08:18:49Z

Activating beta-catenin (CTNNB1) mutations can be identified in the majority of adamantinomatous craniopharyngiomas (adaCP), suggesting an aberrant Wnt signaling pathway in this histopathologically peculiar tumor entity. However, there is no proven evidence that nuclear translocation of beta-catenin is associated with CTNNB1 mutations and target gene activation. We performed a laser-microdissectio...<br/><br/>Annett Hölsken, Jürgen Kreutzer, Bernd M Hofmann, Volkmar Hans, Falk Oppel, Michael Buchfelder, Rudolf Fahlbusch, Ingmar Blümcke, Rolf Buslei (2009) <i>Brain Pathol</i> <i></i> <i></i> 19: 3 357-364<br/>

http://publicationslist.org/volkmar.hans/refid73 2010-04-30T08:18:49Z

Forkhead box P1 (FOXP1) protein is a transcription factor involved in cell signaling and regulation of gene expression. The overexpression of FOXP1 in a subgroup of systemic diffuse large B-cell lymphomas has been associated with an exceptionally poor clinical outcome. Data on FOXP1 expression in primary central nervous system lymphomas (PCNSL), that is, diffuse large B-cell lymphomas confined to ...<br/><br/>Cornelius Courts, Anna Brunn, Manuel Montesinos-Rongen, Dörte Siemer, Volkmar Hans, Werner Paulus, Otmar D Wiestler, Ralf Küppers, Reiner Siebert, Martina Deckert (2009) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 68: 9 972-976<br/>

http://publicationslist.org/volkmar.hans/refid72 2010-04-30T08:18:49Z

We report the clinical presentation, neuroradiologic characteristics, and detailed histopathologic findings in a unique case of drug-resistant focal epilepsy due to sublobar dysplasia (SLD), treated successfully by resection of the malformed cortex. Histopathology with leptomeningeal and subcortical heterotopia, disturbance of cortical lamination and marked cortical and subcortical astrocytosis, b...<br/><br/>Ingrid Tuxhorn, Friedrich G Woermann, Heinz W Pannek, Volkmar H Hans (2009) <i>Epilepsia</i> <i></i> <i></i> 50: 12 2652-2657<br/>

http://publicationslist.org/volkmar.hans/refid74 2012-01-25T09:58:45Z

Inflammatory myopathy with abundant macrophages (IMAM) and dermatomyositis (DM) are considered to represent related disorders, since they share inflammatory infiltrates and skin alterations. In order to get more insight into these disorders, we addressed the cellular composition of the inflammatory infiltrates in muscle biopsies of 11 patients with IMAM and DM. In IMAM, inflammatory infiltrates pr...<br/><br/>Anna Brunn, Volkmar J Hans, Silke Vogelgesang, Martina Deckert (2009) <i>Acta Neuropathol</i> <i></i> <i></i> 118: 6 793-801<br/>

http://publicationslist.org/volkmar.hans/refid3 2009-03-25T07:14:54Z

Cogan's syndrome is a rare clinical entity characterized by non-infectious interstitial keratitis with vestibuloauditory dysfunction. The clinical course is extremely variable. In the majority of patients, there appears to be an underlying systemic process, often a "vasculitis". We were able to study for the first time a sural nerve biopsy of a 38-year-old female with clinically suggested Cogan's ...<br/><br/>Kay W Nolte, Volkmar J Hans, Christoph Schattenfroh, Joachim Weis, J Michael Schröder (2008) <i>Acta Neuropathol</i> <i></i> <i></i> 115: 5 589-596<br/>

http://publicationslist.org/volkmar.hans/refid52 2009-03-25T07:14:54Z

Volkmar H Hans, Rafael Villagrán (2008) <i>Epilepsia</i> <i></i> <i></i> 49: 1 180-181<br/>

http://publicationslist.org/volkmar.hans/refid68 2009-03-25T07:14:54Z

Primary lymphomas of the CNS (PCNSLs) show molecular features of the late germinal center exit B-cell phenotype and are impaired in their terminal differentiation as indicated by a lack of immunoglobulin class switching. Because the positive regulatory domain I protein with ZNF domain (PRDM1/BLIMP1) is a master regulator of terminal B-cell differentiation into plasma cells, we investigated a serie...<br/><br/>Cornelius Courts, Manuel Montesinos-Rongen, Anna Brunn, Stefanie Bug, Dörte Siemer, Volkmar Hans, Ingmar Blümcke, Wolfram Klapper, Carlo Schaller, Otmar D Wiestler, Ralf Küppers, Reiner Siebert, Martina Deckert (2008) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 67: 7 720-727<br/>

http://publicationslist.org/volkmar.hans/refid5 2007-12-10T10:57:41Z

OBJECTIVE: The current histopathological criteria of Rasmussen's encephalitis (RE) include the presence of T-cell-dominated inflammation, microglial activation, neuronal loss, and astrocytic activation. An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ. METHODS: Histochemical, immun...<br/><br/>Jan Bauer, Christian E Elger, Volkmar H Hans, Johannes Schramm, Horst Urbach, Hans Lassmann, Christian G Bien (2007) <i>Ann Neurol</i> <i></i> <i></i> 62: 1 67-80<br/>

http://publicationslist.org/volkmar.hans/refid6 2007-12-10T10:57:41Z

Coenzyme Q10 (CoQ10) deficiency is an autosomal recessive disorder with heterogenous phenotypic manifestations and genetic background. We describe seven patients from five independent families with an isolated myopathic phenotype of CoQ10 deficiency. The clinical, histological and biochemical presentation of our patients was very homogenous. All patients presented with exercise intolerance, fatigu...<br/><br/>Klaus Gempel, Haluk Topaloglu, Beril Talim, Peter Schneiderat, Benedikt G H Schoser, Volkmar H Hans, Beatrix Pálmafy, Gulsev Kale, Aysegul Tokatli, Catarina Quinzii, Michio Hirano, Ali Naini, Salvatore DiMauro, Holger Prokisch, Hanns Lochmüller, Rita Horvath (2007) <i>Brain</i> <i></i> <i></i> 130: Pt 8 2037-2044<br/>

http://publicationslist.org/volkmar.hans/refid7 2007-12-10T10:57:41Z

Activation of the Wnt/wingless signalling cascade is a key mechanism in developmental morphogenesis, whereas aberrant nuclear accumulation of beta-catenin in adult tissues seems to be associated with neoplastic transformation and tumour progression. Adamantinomatous craniopharyngiomas carry activating mutations in exon 3 of the beta-catenin gene, which results in a distinct pattern of nuclear beta...<br/><br/>Rolf Buslei, Annett Hölsken, Bernd Hofmann, Jürgen Kreutzer, Florian Siebzehnrubl, Volkmar Hans, Falk Oppel, Michael Buchfelder, Rudolf Fahlbusch, Ingmar Blümcke (2007) <i>Acta Neuropathol</i> <i></i> <i></i> 113: 5 585-590<br/>

http://publicationslist.org/volkmar.hans/refid4 2008-02-01T13:12:24Z

In medical image analysis the image content is often represented by features computed from the pixel matrix in order to support the development of improved clinical diagnosis systems. These features need to be interpreted and understood at a clinical level of understanding Many features are of abstract nature, as for instance features derived from a wavelet transform. The interpretation and analys...<br/><br/>B Lessmann, T W Nattkemper, V H Hans, A Degenhard (2007) <i>J Biomed Inform</i> <i></i> <i></i> 40: 6 631-641<br/>

http://publicationslist.org/volkmar.hans/refid1 2009-03-25T07:14:54Z

Tatjana Shmidt, Franziska Hampich, Michael Ridders, Stefanie Schultrich, Volkmar H Hans, Katja Tenner, Larissa Vilianovich, Fatimunnisa Qadri, Natalia Alenina, Enno Hartmann, Matthias Köhler, Michael Bader (2007) <i>Nat Cell Biol</i> <i></i> <i></i> 9: 12 1337-8; author reply 1339<br/>

http://publicationslist.org/volkmar.hans/refid2 2008-02-01T13:12:24Z

Angiocentric glioma has recently been described as a novel epilepsy associated tumor with distinct clinico-pathologic features. We report the clinical and pathologic findings in 8 additional cases of this rare tumor type and extend its characterization by genomic profiling. Almost all patients had a history of long-standing drug-resistant epilepsy. Cortico-subcortical tumors were located in the te...<br/><br/>Matthias Preusser, Alexander Hoischen, Klaus Novak, Thomas Czech, Daniela Prayer, Johannes A Hainfellner, Christoph Baumgartner, Friedrich G Woermann, Ingrid E Tuxhorn, Heinz W Pannek, Markus Bergmann, Bernhard Radlwimmer, Rafael Villagrán, Ruthild G Weber, Volkmar H Hans (2007) <i>Am J Surg Pathol</i> <i></i> <i></i> 31: 11 1709-1718<br/>

http://publicationslist.org/volkmar.hans/refid11 2007-12-10T10:57:41Z

OBJECTIVE: In adults, supratentorial primitive neuroectodermal tumor (sPNET) is a very rare undifferentiated embryoblastic neoplasm. Prognosis is worse in comparison to infratentorial medulloblastoma. Older age appears to be prognostically favorable. At present, 5-year survival rates remain below 50% in all age groups. Survival longer than 15 years in an adult has only been reported once so far. C...<br/><br/>Thomas Krampulz, Volkmar H Hans, Falk Oppel, Uwe Dietrich, Maximilian J A Puchner (2006) <i>J Neurooncol</i> <i></i> <i></i> 77: 3 291-294<br/>

http://publicationslist.org/volkmar.hans/refid10 2007-12-10T10:57:41Z

OBJECTIVE: Primary hypophysitis comprises of three distinct histomorphological entities: lymphocytic, granulomatous and xanthomatous. Clinical features of the three subtypes for diagnostic and treatment strategies have yet not been well characterized. METHODS: Endocrine function, visual fields and acuity as well as magnetic resonance imaging characteristics were assessed before and after transphen...<br/><br/>Angelika Gutenberg, Volkmar Hans, Maximilian J A Puchner, Jürgen Kreutzer, Wolfgang Brück, Patrizio Caturegli, Michael Buchfelder (2006) <i>Eur J Endocrinol</i> <i></i> <i></i> 155: 1 101-107<br/>

http://publicationslist.org/volkmar.hans/refid12 2007-12-10T10:57:41Z

Glioneuronal malformations (malformations of cortical development [MCD]) include focal cortical dysplasias (FCD) as well as highly differentiated glioneuronal tumors (i.e. gangliogliomas) and constitute frequent findings in patients with pharmacoresistent focal epilepsies. Tailored resection strategies evolved as promising treatment options and allow a systematic neuropathologic and molecular biol...<br/><br/>Albert J Becker, Ingmar Blümcke, Horst Urbach, Volkmar Hans, Michael Majores (2006) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 65: 2 99-108<br/>

http://publicationslist.org/volkmar.hans/refid9 2007-12-10T10:57:41Z

Primary central nervous system lymphomas (PCNSLs) are diffuse large B cell lymphomas confined to the brain. Only minimal data exist on chromosomal aberrations underlying PCNSLs. We studied 41 PCNSLs by fluorescence in situ hybridization for breakpoints affecting the BCL6 locus in chromosomal band 3q27. Of 37 cases evaluable, 14 (38%) carried a breakpoint in the BCL6 locus. Two of these showed juxt...<br/><br/>Heinrich Schwindt, Takashi Akasaka, Reina Zühlke-Jenisch, Volkmar Hans, Carlo Schaller, Wolfram Klapper, Martin J S Dyer, Reiner Siebert, Martina Deckert (2006) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 65: 8 776-782<br/>

http://publicationslist.org/volkmar.hans/refid8 2007-12-10T10:57:41Z

The prognostic significance of atypical histologic features in choroid plexus tumors remains uncertain. Therefore, a series of 164 choroid plexus tumors was evaluated for the presence of atypical histologic features, including mitotic activity, increased cellularity, nuclear pleomorphism, blurring of papillary growth pattern, and necrosis. The impact of histopathologic and clinical features on the...<br/><br/>Astrid Jeibmann, Martin Hasselblatt, Joachim Gerss, Brigitte Wrede, Rupert Egensperger, Rudi Beschorner, Volkmar H J Hans, Christian H Rickert, Johannes E Wolff, Werner Paulus (2006) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 65: 11 1069-1073<br/>

http://publicationslist.org/volkmar.hans/refid16 2007-12-10T10:57:41Z

Mutations in the valosin-containing protein (VCP) gene on chromosome 9p13-p12 recently have been shown to cause autosomal dominant inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. Here, we report the central nervous system autopsy findings in a 55-year-old German patient with inclusion body myopathy and frontotemporal dementia who harbors a heterozyg...<br/><br/>Rolf Schröder, Giles D J Watts, Sarju G Mehta, Bernd O Evert, Petra Broich, Klaus Fliessbach, Katharina Pauls, Volkmar H Hans, Virginia Kimonis, Dietmar R Thal (2005) <i>Ann Neurol</i> <i></i> <i></i> 57: 3 457-461<br/>

http://publicationslist.org/volkmar.hans/refid15 2007-12-10T10:57:41Z

Daniel Hänggi, Heiner Adams, Volkmar H Hans, Alphonse Probst, Markus Tolnay (2005) <i>Acta Neuropathol</i> <i></i> <i></i> 110: 1 93-96<br/>

http://publicationslist.org/volkmar.hans/refid14 2007-12-10T10:57:41Z

Mammalian neurofilaments (NFs) are modified by post-translational modifications that are thought to regulate NF assembly and organization. Whereas phosphorylation has been intensely studied, the role of another common modification, the attachment of O-linked N-acetylglucosamine (GlcNAc) to individual serine and threonine residues, is hardly understood. We generated a novel monoclonal antibody that...<br/><br/>Nina Lüdemann, Albrecht Clement, Volkmar H Hans, Julia Leschik, Christian Behl, Roland Brandt (2005) <i>J Biol Chem</i> <i></i> <i></i> 280: 36 31648-31658<br/>

http://publicationslist.org/volkmar.hans/refid13 2007-12-10T10:57:41Z

Epilepsy-associated malformations of cortical development (MCDs) comprise a variety of dysplastic and neoplastic lesions of yet undetermined molecular pathology. Histopathologic similarities between MCDs and dysplastic brain lesions in the autosomal inherited neurocutaneous phacomatosis tuberous sclerosis (TSC), which affects the TSC1 and/or TSC2 genes, suggest common pathogenetic mechanisms. Prev...<br/><br/>Michael Majores, Ingmar Blümcke, Horst Urbach, Alessandra Meroni, Volkmar Hans, Hans Holthausen, Christian E Elger, Johannes Schramm, Carlo Galli, Roberto Spreafico, Otmar D Wiestler, Albert J Becker (2005) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 64: 7 629-637<br/>

http://publicationslist.org/volkmar.hans/refid20 2007-12-10T10:57:41Z

Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are suggested to be important neurosteroids. We investigated steroid sulfatase (STS) in human temporal lobe biopsies in the context of possible cerebral DHEA(S) de novo biosynthesis. Formation of DHEA(S) in mature human brain tissue has not yet been studied. 17 alpha-Hydroxylase/C17-20-lyase and hydroxysteroid sulfotransferase catalyze the form...<br/><br/>Stephan Steckelbroeck, Alexander Nassen, Bernhard Ugele, Michael Ludwig, Matthias Watzka, Annette Reissinger, Hans Clusmann, Dieter Lütjohann, Lothar Siekmann, Dietrich Klingmüller, Volkmar H Hans (2004) <i>J Neurochem</i> <i></i> <i></i> 89: 2 403-417<br/>

http://publicationslist.org/volkmar.hans/refid19 2007-12-10T10:57:41Z

Idiopathic hypertrophic chronic pachymeningitis (IHCP) is characterised by inflammatory fibrotic thickening of the dura mater. Long term management is controversial. A 28 year old man with craniospinal IHCP and prominent lymphocytic meningitis is reported. Cerebrospinal fluid and histological examination suggested a CD4+ T cell driven process and B cell stimulation. After surgical, tuberculostatic...<br/><br/>I Kleiter, V H Hans, G Schuierer, J Marienhagen, P Hau, H Schütz, U Bogdahn, A Steinbrecher (2004) <i>J Neurol Neurosurg Psychiatry</i> <i></i> <i></i> 75: 9 1346-1348<br/>

http://publicationslist.org/volkmar.hans/refid21 2007-12-10T10:57:41Z

Severe focal epilepsy is regarded as a clinical hallmark of Rasmussen encephalitis (RE). The authors report two children with progressive hemiparesis, contralateral hemispheric atrophy, and pathologic features characteristic for RE. At histologic diagnosis and over several months, neither patient experienced seizures. The report enlarges the clinical spectrum of RE and suggests that seizures are n...<br/><br/>I Korn-Lubetzki, C G Bien, J Bauer, M Gomori, H Wiendl, L Trajo, H Ovadia, B Wilken, V H Hans, C E Elger, H Hurvitz, I Steiner (2004) <i>Neurology</i> <i></i> <i></i> 62: 6 984-986<br/>

http://publicationslist.org/volkmar.hans/refid17 2007-12-10T10:57:41Z

Malignant gliomas are the most frequent primary brain tumors and have a dismal prognosis due to their infiltrative growth. Gene therapy using viral vectors represents an attractive alternative to conventional cancer therapies. In a previous study, we established lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus (LCMV) glycoproteins (GPs) and demonstrated transduction of human ...<br/><br/>Hrvoje Miletic, Yvonne Heidemarie Fischer, Harald Neumann, Volkmar Hans, Werner Stenzel, Tsanan Giroglou, Manuel Hermann, Martina Deckert, Dorothee Von Laer (2004) <i>Hum Gene Ther</i> <i></i> <i></i> 15: 11 1091-1100<br/>

http://publicationslist.org/volkmar.hans/refid18 2007-12-10T10:57:41Z

The authors describe the first case of an intracranial transition of a melanocytoma into a primary malignant melanoma within a short time. A 37-year-old woman presented with progressive brainstem syndrome due to a tumor, originally diagnosed and treated 12 years earlier, that extended from the petroclival area to the anterior craniocervical junction. The histological workup following subtotal tumo...<br/><br/>Florian Roser, Makoto Nakamura, Almuth Brandis, Volkmar Hans, Peter Vorkapic, Madjid Samii (2004) <i>J Neurosurg</i> <i></i> <i></i> 101: 3 528-531<br/>

http://publicationslist.org/volkmar.hans/refid22 2007-12-10T10:57:41Z

Microsatellite instability (MSI) is a characteristic feature of up to 15% of colorectal cancers (CRC) and is associated with better response to adjuvant chemotherapy with 5-fluorouracil (5-FU). In this study we have investigated the association between the MSI status and the mRNA expression as well as the polymorphisms of the cellular target of 5-FU therapy, thymidylate synthase. Polymorphisms in ...<br/><br/>Sabine Merkelbach-Bruse, Volkmar Hans, Micaela Mathiak, Rosario Sanguedolce, Riccardo Alessandro, Josef Rüschoff, Reinhard Büttner, Farzad Houshdaran, Lucia Gullotti (2004) <i>Oncol Rep</i> <i></i> <i></i> 11: 4 839-843<br/>

http://publicationslist.org/volkmar.hans/refid24 2007-12-10T10:57:41Z

Estrogens play a crucial role in multiple functions of the brain and the proper balance of inactive estrone and active estradiol-17beta might be very important for their cerebral effects. The interconversion of estrone and estradiol-17beta in target tissues is known to be catalysed by a number of human 17beta-hydroxysteroid dehydrogenase (17beta-HSD) isoforms. The present study shows that enzyme c...<br/><br/>Stephan Steckelbroeck, Matthias Watzka, Annette Reissinger, Petra Wegener-Toper, Frank Bidlingmaier, Niklaas Bliesener, Volkmar H J Hans, Hans Clusmann, Michael Ludwig, Lothar Siekmann, Dietrich Klingmüller (2003) <i>J Steroid Biochem Mol Biol</i> <i></i> <i></i> 86: 1 79-92<br/>

http://publicationslist.org/volkmar.hans/refid23 2007-12-10T10:57:41Z

OBJECTIVE: To study the regional oxygen saturation (rSO(2)) of pituitary adenomas, in comparison with that of the pituitary gland. METHODS: Microspectrophotometric (MSP) measurements of rSO(2) in adenomas and pituitary tissue were performed for a series of patients undergoing first-time transsphenoidal pituitary adenoma surgery, in a standardized anesthesia setting. The areas of measured tissue we...<br/><br/>Rudolf A Kristof, Ales F Aliashkevich, Volkmar Hans, Dorothee Haun, Bernhard Meyer, Christoph Thees, Johannes Schramm (2003) <i>Neurosurgery</i> <i></i> <i></i> 53: 4 880-5; discussion 885-6<br/>

http://publicationslist.org/volkmar.hans/refid25 2007-12-10T10:57:41Z

Gastrointestinal stromal tumors (GISTs) typically express high levels of the Kit-receptor. The majority of GISTs carry mutations in the c-kit protooncogene clustering in exon 11. The significance of c-kit mutations for the biological behavior of GISTs is still under discussion. We evaluated 55 sporadic GISTs with available follow-up data for c-kit mutations in the juxtamembrane domain and detected...<br/><br/>Eva Wardelmann, Inge Losen, Volkmar Hans, Iris Neidt, Nicola Speidel, Erhard Bierhoff, Thomas Heinicke, Torsten Pietsch, Reinhard Büttner, Sabine Merkelbach-Bruse (2003) <i>Int J Cancer</i> <i></i> <i></i> 106: 6 887-895<br/>

http://publicationslist.org/volkmar.hans/refid27 2007-12-10T10:57:41Z

Dehydroepiandrosterone and its sulphate are important factors for vitality, development and functions of the CNS. They were found to be subjects to a series of enzyme-mediated conversions within the rodent CNS. In the present study, we were able to demonstrate for the first time that membrane-associated dehydroepiandrosterone 7alpha-hydroxylase activity occurs within the human brain. The cytochrom...<br/><br/>Stephan Steckelbroeck, Matthias Watzka, Dieter Lütjohann, Paul Makiola, Alexander Nassen, Volkmar H J Hans, Hans Clusmann, Annette Reissinger, Michael Ludwig, Lothar Siekmann, Dietrich Klingmüller (2002) <i>J Neurochem</i> <i></i> <i></i> 83: 3 713-726<br/>

http://publicationslist.org/volkmar.hans/refid29 2007-12-10T10:57:41Z

An intrasellar lesion resembling a hormone-inactive pituitary adenoma was resected in a 59-year-old woman. The well-differentiated benign tumor was composed of ganglion-like cells, clusters of adenohypophyseal tissue as well as a GH-expressing adenoma. In addition, small cells exhibited an intermediate neuronal and epithelial immunoreactivity. Surrounding the tumor was a spindle cell component tha...<br/><br/>Volkmar H J Hans, Horst Urbach, Rudolph A Kristof, Martina Deckert (2002) <i>Brain Pathol</i> <i></i> <i></i> 12: 3 391-2, 397<br/>

http://publicationslist.org/volkmar.hans/refid28 2007-12-10T10:57:41Z

The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocytomas (AIII), oligodendrogliomas (OIII) and oligoastrocytomas (OAIII) WHO grade III. The treatment was carried out in 48 patients: 24 AIII, 20 OAIII and four OIII, at the same medical institu...<br/><br/>Rudolf A Kristof, Georg Neuloh, Volkmar Hans, Martina Deckert, Horst Urbach, Uwe Schlegel, Matthias Simon, Johannes Schramm (2002) <i>J Neurooncol</i> <i></i> <i></i> 59: 3 231-237<br/>

http://publicationslist.org/volkmar.hans/refid26 2007-12-10T10:57:41Z

We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16. Ectopic p16 expression led to a stable but reversible G1 phase cell cycle arrest, reduced the growth of both cell lines in cell culture, and almost abolished their in vitro tumorigenicity. U-87MG-tTA-p16 glioblastoma cells consi...<br/><br/>Matthias Simon, Christian Simon, Gertraud Köster, Volkmar H J Hans, Johannes Schramm (2002) <i>J Neurooncol</i> <i></i> <i></i> 60: 1 1-12<br/>

http://publicationslist.org/volkmar.hans/refid34 2007-12-10T10:57:41Z

Cerebrospinal fluid (CSF) absorption was investigated chicken and rat using infusion tests into the cisterna magna. Data were analysed according to a mathematical model by Johnson et al. Results in rat predicted a predominant lymphatic mechanism, which was confirmed by rapid outflow of X-ray contrast media into the olfactoric mucosa. In contrast, dynamics measurements suggested CSF drainage via ar...<br/><br/>U Kelkenberg, D B von Rautenfeld, T Brinker, V H Hans (2001) <i>Neuroreport</i> <i></i> <i></i> 12: 3 553-557<br/>

http://publicationslist.org/volkmar.hans/refid35 2007-12-10T10:57:41Z

The pathophysiology of traumatic axonal injury (TAI) is only partially understood. In this study, we investigated the inflammatory response as well as the extent of neurological deficit in a rat model of traumatic brain injury (TBI). Forty-two adult rats were subjected to moderate impact-acceleration brain injury and their brains were analyzed immunohistochemically for ICAM-1 expression and neutro...<br/><br/>M Rancan, V I Otto, V H Hans, I Gerlach, R Jork, O Trentz, T Kossmann, M C Morganti-Kossmann (2001) <i>J Neurosci Res</i> <i></i> <i></i> 63: 5 438-446<br/>

http://publicationslist.org/volkmar.hans/refid30 2007-12-10T10:57:41Z

Primary central nervous system lymphomas (PCNSL) are derived from germinal center B cells. Recent molecular studies indicate that the tumor cells or their precursors have experienced antigenic stimulation. Attractive candidates for such antigens are pathogens with the capacity to reside in the brain. The aim of the present study was to evaluate whether human herpes virus (HHV)-8 is involved in the...<br/><br/>M Montesinos-Rongen, V H Hans, A M Eis-Hübinger, M Prinz, C Schaller, D Van Roost, A Aguzzi, O D Wiestler, M Deckert (2001) <i>Acta Neuropathol</i> <i></i> <i></i> 102: 5 489-495<br/>

http://publicationslist.org/volkmar.hans/refid33 2007-12-10T10:57:41Z

Although androgen metabolism in the human brain was discovered almost 30 yr ago, conclusive studies on the enzymes involved are still lacking. We therefore investigated 5alpha-reductase and colocalized 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity in cerebral neocortex (CX) and subcortical white matter (SC) specimens neurosurgically removed from 44 patients suffering from epilepsy. We ...<br/><br/>S Steckelbroeck, M Watzka, R Reichelt, V H Hans, B Stoffel-Wagner, D D Heidrich, J Schramm, F Bidlingmaier, D Klingmüller (2001) <i>J Clin Endocrinol Metab</i> <i></i> <i></i> 86: 3 1324-1331<br/>

http://publicationslist.org/volkmar.hans/refid36 2007-12-10T10:57:41Z

An enzyme-mediated metabolism of androgens and estrogens including 17beta-HSD activity in the brain of vertebrates was discovered approximately 30 years ago. Mainly 5alpha-reductase and aromatase have been studied in detail. Recently we could demonstrate reductive and oxidative 17beta-HSD activity as well as considerable mRNA expression of the 17beta-HSD types 3 and 4 in the human brain. In the pr...<br/><br/>S Steckelbroeck, M Watzka, B Stoffel-Wagner, V H Hans, L Redel, H Clusmann, C E Elger, F Bidlingmaier, D Klingmüller (2001) <i>Mol Cell Endocrinol</i> <i></i> <i></i> 171: 1-2 165-168<br/>

http://publicationslist.org/volkmar.hans/refid32 2007-12-10T10:57:41Z

The brain is believed to be an immunologically privileged organ, sheltered from the systemic immunological defense by the blood-brain barrier (BBB). However, there is increasing evidence for a marked inflammatory response in the brain after traumatic brain injury (TBI). Markers for cellular immune activation, neopterin, beta2-microglobulin (beta2M), and soluble interleukin-2 receptor (sIL-2R), wer...<br/><br/>P M Lenzlinger, V H Hans, H I Jöller-Jemelka, O Trentz, M C Morganti-Kossmann, T Kossmann (2001) <i>J Neurotrauma</i> <i></i> <i></i> 18: 5 479-489<br/>

http://publicationslist.org/volkmar.hans/refid31 2007-12-10T10:57:41Z

Microtubule-associated protein 2 (MAP2), a protein linked to the neuronal cytoskeleton in the mature central nervous system (CNS), has recently been identified in glial precursors indicating a potential role during glial development. In the present study, we systematically analyzed the expression of MAP2 in a series of 237 human neuroepithelial tumors including paraffin-embedded specimens and tumo...<br/><br/>I Blümcke, A J Becker, S Normann, V Hans, B M Riederer, S Krajewski, O D Wiestler, G Reifenberger (2001) <i>J Neuropathol Exp Neurol</i> <i></i> <i></i> 60: 10 984-993<br/>

http://publicationslist.org/volkmar.hans/refid39 2007-12-10T10:57:41Z

M C Sabel, V H Hans, G Reifenberger (2000) <i>Arch Neurol</i> <i></i> <i></i> 57: 4 587-588<br/>

http://publicationslist.org/volkmar.hans/refid38 2007-12-10T10:57:41Z

OBJECT: In recent reports, 6 to 19% of meningiomas have been classified as atypical or anaplastic/malignant. Some atypical and anaplastic meningiomas appear to arise from benign tumors by progression. Telomerase activation has recently been associated with malignant progression of human tumors. The authors have investigated a series of benign, atypical, and anaplastic/malignant meningiomas for tel...<br/><br/>M Simon, T W Park, S Leuenroth, V H Hans, T Löning, J Schramm (2000) <i>J Neurosurg</i> <i></i> <i></i> 92: 5 832-840<br/>

http://publicationslist.org/volkmar.hans/refid37 2007-12-10T10:57:41Z

In a rat model of traumatic brain injury cell activation was characterized immunohistochemically from 2 h up to 2 weeks. Reactive astrocytosis became apparent perivascularly and in the grey matter within 4h after trauma. Increased OX42 immunoreactivity indicated microglial activation in cortex and hippocampus as early as 4 h, whereas up-regulation of MHC class II (OX6) was evident in white matter ...<br/><br/>E Csuka, V H Hans, E Ammann, O Trentz, T Kossmann, M C Morganti-Kossmann (2000) <i>Neuroreport</i> <i></i> <i></i> 11: 11 2587-2590<br/>

http://publicationslist.org/volkmar.hans/refid42 2007-12-10T10:57:41Z

Interleukin-6 (IL-6) and its soluble receptor (sIL-6-R) were measured in cerebrospinal fluid (CSF) and serum of 11 severely head injured patients for up to 3 weeks following trauma. IL-6 increased immediately after injury displaying much higher concentrations in CSF than in serum (n = 11). Differently, median levels of sIL-6-R remained in the normal ranges being 10 times higher in serum than in CS...<br/><br/>V H Hans, T Kossmann, H Joller, V Otto, M C Morganti-Kossmann (1999) <i>Neuroreport</i> <i></i> <i></i> 10: 2 409-412<br/>

http://publicationslist.org/volkmar.hans/refid43 2007-12-10T10:57:41Z

Diffuse axonal injury is a frequent pathologic sequel of head trauma, which, despite its devastating consequences for the patients, remains to be fully elucidated. Here we studied the release of interleukin-6 (IL-6) into CSF and serum, as well as the expression of IL-6 messenger ribonucleic acid (mRNA) and protein in a weight drop model of axonal injury in the rat. The IL-6 activity was elevated i...<br/><br/>V H Hans, T Kossmann, P M Lenzlinger, R Probstmeier, H G Imhof, O Trentz, M C Morganti-Kossmann (1999) <i>J Cereb Blood Flow Metab</i> <i></i> <i></i> 19: 2 184-194<br/>

http://publicationslist.org/volkmar.hans/refid41 2007-12-10T10:57:41Z

Local aromatase-mediated conversion of androgens plays an important role in androgen action on the brain. To characterize estrogen formation in the human brain, we measured the microsomal aromatase activity of temporal lobe biopsies and compared it to that of human placenta using a highly sensitive 3H2O assay with [1beta-3H]androstenedione as substrate. Brain tissue was removed neurosurgically fro...<br/><br/>S Steckelbroeck, D D Heidrich, B Stoffel-Wagner, V H Hans, J Schramm, F Bidlingmaier, D Klingmüller (1999) <i>J Clin Endocrinol Metab</i> <i></i> <i></i> 84: 8 2795-2801<br/>

http://publicationslist.org/volkmar.hans/refid40 2007-12-10T10:57:41Z

Traumatic brain injury (TBI) induces local and systemic immunologic changes, release of cytokines, and cell activation. Perpetuation of these cascades may contribute to secondary damage to the brain. Therefore, the ability of the antiinflammatory mediator transforming growth factor-beta (TGF-beta) to downregulate intrathecal immunoactivation may be of fundamental value for diminishing the incidenc...<br/><br/>M C Morganti-Kossmann, V H Hans, P M Lenzlinger, R Dubs, E Ludwig, O Trentz, T Kossmann (1999) <i>J Neurotrauma</i> <i></i> <i></i> 16: 7 617-628<br/>

http://publicationslist.org/volkmar.hans/refid45 2007-12-10T10:57:41Z

Diffuse brain swelling is a common complication in young victims of a seven head injury but, there is a lack of data on relevant models of injury. We produced diffuse brain injury in 21 day old Lewis rat pups (N = 33) by modifying a recently established weight-drop-model. The trauma threshold, neurological response, histological changes, intracranial pressure (ICP), and arterial blood pressure (AB...<br/><br/>S Thomas, F Tabibnia, M U Schuhmann, V H Hans, T Brinker, M Samii (1998) <i>Acta Neurochir Suppl</i> <i></i> <i></i> 71: 135-137<br/>

http://publicationslist.org/volkmar.hans/refid44 2007-12-10T10:57:41Z

Using ICP measurements and the bolus injection technique dynamic parameters of the cerebrospinal fluid system as there are pressure-volume-index (PVI) and resistance to CSF outflow (Rout) were investigated in a new model of diffuse closed head injury (CHI) in the rat. It was found that in the absence of brain oedema and ICP alterations an increase in PVI and Rout was present in the early (4h) peri...<br/><br/>M U Schuhmann, S Thomas, V H Hans, H Beck, T Brinker, M Samii (1998) <i>Acta Neurochir Suppl</i> <i></i> <i></i> 71: 300-302<br/>

http://publicationslist.org/volkmar.hans/refid47 2007-12-10T10:57:41Z

A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-alpha and TGF-beta were monitored in CSF...<br/><br/>M C Morganti-Kossman, P M Lenzlinger, V Hans, P Stahel, E Csuka, E Ammann, R Stocker, O Trentz, T Kossmann (1997) <i>Mol Psychiatry</i> <i></i> <i></i> 2: 2 133-136<br/>

http://publicationslist.org/volkmar.hans/refid46 2007-12-10T10:57:41Z

Several studies suggest the involvement of the complement system in the pathophysiology of traumatic brain injury (TBI). Since the intrathecal generation of anaphylatoxin C5a has been shown to mediate inflammatory effects within the central nervous system, we sought to characterize the cellular expression of the mRNA for the C5a receptor (C5aR, CD88) in brains of rats with experimental diffuse axo...<br/><br/>P F Stahel, T Kossmann, M C Morganti-Kossmann, V H Hans, S R Barnum (1997) <i>Brain Res Mol Brain Res</i> <i></i> <i></i> 50: 1-2 205-212<br/>

http://publicationslist.org/volkmar.hans/refid49 2007-12-10T10:57:41Z

Cefuroxime levels were measured in cerebrospinal fluid (CSF) and serum of four patients with traumatic brain injury following the implantation of intraventricular catheters. The levels ranged from 0.15 to 2.03 micrograms/mL in CSF and from 1.8 to 66.9 micrograms/mL in serum. No ventriculostomy related infections were detected.<br/><br/>T Kossmann, V Hans, R Stocker, H G Imhof, B Joos, O Trentz, M C Morganti-Kossmann (1996) <i>J Antimicrob Chemother</i> <i></i> <i></i> 37: 1 161-167<br/>

http://publicationslist.org/volkmar.hans/refid48 2007-12-10T10:57:41Z

Cytokines are involved in nerve regeneration by modulating the synthesis of neurotrophic factors. The role played by interleukin-6 (IL-6) in promoting nerve growth factor (NGF) after brain injury was investigated by monitoring the release of IL-6 and NGF in ventricular cerebrospinal fluid (CSF) of 22 patients with severe traumatic brain injuries. IL-6 was found in the CSF of all individuals and re...<br/><br/>T Kossmann, V Hans, H G Imhof, O Trentz, M C Morganti-Kossmann (1996) <i>Brain Res</i> <i></i> <i></i> 713: 1-2 143-152<br/>

http://publicationslist.org/volkmar.hans/refid50 2007-12-10T10:57:41Z

Patients with severe traumatic brain injury (TBI) show a profound acute-phase response. Because interleukin-6 (IL-6) is an important mediator of these pathophysiological changes, IL-6 levels were monitored in the cerebrospinal fluid (CSF) and serum of 20 patients with severe isolated TBI. All patients received indwelling ventricular catheters for intracranial pressure monitoring and for release of...<br/><br/>T Kossmann, V H Hans, H G Imhof, R Stocker, P Grob, O Trentz, C Morganti-Kossmann (1995) <i>Shock</i> <i></i> <i></i> 4: 5 311-317<br/>

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V H Hans, H Rupprecht (1993) <i>Dtsch Med Wochenschr</i> <i></i> <i></i> 118: 31 <br/>