http://publicationslist.org/data/walter.j.jessen/atom.xml Walter Jessenhttp://publicationslist.org/walter.j.jessen$basepathfavicon.icoRecent additions to Walter Jessen's PublicationsList.org pagehttp://publicationslist.org/publications.png2010-12-26T03:36:02Z http://publicationslist.org/walter.j.jessen/refid12 2010-12-26T03:23:33Z

PURPOSE: Plexiform neurofibromas (pNF) are Schwann cell tumors found in a third of individuals with neurofibromatosis type 1 (NF1). pNF can undergo transformation to malignant peripheral nerve sheath tumors (MPNST). There are no identified serum biomarkers of pNF tumor burden or transformation to MPNST. Serum biomarkers would be useful to verify NF1 diagnosis, monitor tumor burden, and/or detect t...<br/><br/>Hummel TR, Jessen WJ, Miller SJ, Kluwe L, Mautner VF, Wallace MR, Lázaro C, Page GP, Worley PF, Aronow BJ, Schorry EK, Ratner N. (2010) <i> Clin Cancer Res.</i> 16: 20 5048-57<br/>

http://publicationslist.org/walter.j.jessen/refid11 2010-12-26T03:23:48Z

Understanding the biological pathways critical for common neurofibromatosis type 1 (NF1) peripheral nerve tumours is essential, as there is a lack of tumour biomarkers, prognostic factors and therapeutics. We used gene expression profiling to define transcriptional changes between primary normal Schwann cells (n = 10), NF1-derived primary benign neurofibroma Schwann cells (NFSCs) (n = 22), maligna...<br/><br/>SJ Miller*, WJ Jessen*, T Mehta, A Hardiman, E Sites, S Kaiser, A Jegga, H Li, M Upadhyaya, M Giovannini, D Muir, MR Wallace, E Lopez, E Serra, GP Nielsen, C Lazaro, A Stemmer-Rachamimov, G Page, BJ Aronow and N Ratner. (2009) <i>EMBO Mol Med</i> 1: 4 236-248<br/>

http://publicationslist.org/walter.j.jessen/refid2 2009-02-05T03:24:30Z

To identify biomarkers that discriminate the aggressive forms of prostate cancer, we performed gene expression profiling of prostate tumors using a genetically engineered mouse model that recapitulates the stages of human prostate cancer, namely Nkx3.1; Pten mutant mice. We observed a significant deregulation of the epidermal growth factor and mitogen-activated protein kinase (MAPK) signaling path...<br/><br/>Xuesong Ouyang, Walter J Jessen, Hikmat Al-Ahmadie, Angel M Serio, Yong Lin, Weichung-Joseph Shih, Victor E Reuter, Peter T Scardino, Michael M Shen, Bruce J Aronow, Andrew J Vickers, William L Gerald, Cory Abate-Shen (2008) <i>Cancer Res</i> 68: 7 2132-2144<br/>

http://publicationslist.org/walter.j.jessen/refid1 2009-02-05T03:22:20Z

Factors that drive prostate cancer progression remain poorly defined, thus hindering the development of new therapeutic strategies. Disseminated tumors are treated through regimens that ablate androgen signaling, as prostate cancer cells require androgen for growth and survival. However, recurrent, incurable tumors that have bypassed the androgen requirement ultimately arise. This study reveals th...<br/><br/>Hui Shen, Nathan Powers, Nitin Saini, Clay E S Comstock, Ankur Sharma, Katherine Weaver, Monica P Revelo, William Gerald, Erin Williams, Walter J Jessen, Bruce J Aronow, Gary Rosson, Bernard Weissman, Christian Muchardt, Moshe Yaniv, Karen E Knudsen (2008) <i>Cancer Res</i> 68: 24 10154-10162<br/>

http://publicationslist.org/walter.j.jessen/refid5 2009-02-07T02:34:55Z

BACKGROUND: The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic day...<br/><br/>Sergio Kaiser, Young-Kyu Park, Jeffrey L Franklin, Richard B Halberg, Ming Yu, Walter J Jessen, Johannes Freudenberg, Xiaodi Chen, Kevin Haigis, Anil G Jegga, Sue Kong, Bhuvaneswari Sakthivel, Huan Xu, Timothy Reichling, Mohammad Azhar, Gregory P Boivin, Reade B Roberts, Anika C Bissahoyo, Fausto Gonzales, Greg C Bloom, Steven Eschrich, Scott L Carter, Jeremy E Aronow, John Kleimeyer, Michael Kleimeyer, Vivek Ramaswamy, Stephen H Settle, Braden Boone, Shawn Levy, Jonathan M Graff, Thomas Doetschman, Joanna Groden, William F Dove, David W Threadgill, Timothy J Yeatman, Robert J Coffey, Bruce J Aronow (2007) <i>Genome Biol</i> 8: 7 <br/>

http://publicationslist.org/walter.j.jessen/refid9 2009-02-05T03:41:18Z

Androgens, particularly testosterone and its potent metabolite 5-α-dihydrotestosterone, serve as critical mediators in the development and maintenance of the male reproductive and non-reproductive systems. Androgen-dependent signaling is conveyed by the androgen receptor (AR), which is a member of the nuclear receptor superfamily. AR binding of androgen stimulates its ability to bind DNA and regu...<br/><br/>CES Comstock, CJ Burd, WJ Jessen, KE Knudsen (2007) <i>Contemporary Endocrinology: Genomics in Endocrinology, DNA Microarray Analysis in Endocrine Health and Disease.</i> 83-113<br/>

http://publicationslist.org/walter.j.jessen/refid3 2009-02-05T03:26:10Z

In this report, we have investigated the relationship between androgen levels and prostate tumorigenesis in Nkx3.1; Pten mutant mice, a genetically engineered mouse model of human prostate cancer. By experimentally manipulating serum levels of testosterone in these mice for an extended period (i.e., 7 months), we have found that prolonged exposure of Nkx3.1; Pten mutant mice to androgen levels tha...<br/><br/>Whitney Banach-Petrosky, Walter J Jessen, Xuesong Ouyang, Hui Gao, Jayashree Rao, John Quinn, Bruce J Aronow, Cory Abate-Shen (2007) <i>Cancer Res</i> 67: 19 9089-9096<br/>

http://publicationslist.org/walter.j.jessen/refid4 2009-02-05T03:28:58Z

BACKGROUND: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental technologies, gene expression microarrays and Chromatin Immuno-Precipitation on Chip (ChIP-chip), are capable of producing data informative about expression regulatory mechanism on a genome scale. The optimal approach to ...<br/><br/>Xiangdong Liu, Walter J Jessen, Siva Sivaganesan, Bruce J Aronow, Mario Medvedovic (2007) <i>BMC Bioinformatics</i> 8: <br/>

http://publicationslist.org/walter.j.jessen/refid6 2009-02-05T03:31:06Z

Transcriptional activation is often associated with chromatin remodeling. However, little is known about the dynamics of remodeling of nucleosome arrays in vivo. Upon induction of Saccharomyces cerevisiae PHO5, a novel kinetic assay of DNA methyltransferase accessibility showed that nucleosomes adjacent to the histone-free upstream activating sequence (UASp1) are disrupted earlier and at higher fr...<br/><br/>Walter J Jessen, Scott A Hoose, Jessica A Kilgore, Michael P Kladde (2006) <i>Nat Struct Mol Biol</i> 13: 3 256-263<br/>

http://publicationslist.org/walter.j.jessen/refid10 2009-02-05T01:56:08Z

Promoter transactivation is often associated with the disruption or remodeling of nucleosomes in chromatin. The budding yeast PHO5 promoter, which drives expression of the major secreted acid phosphatase, is a proven model system for investigating gene regulatory mechanisms in the context of chromatin. Under conditions of high external phosphate concentration, PHO5 transcription is repressed throu...<br/><br/>JA Kilgore, SA Hoose, A Dhasarathy, DW Neef, WJ Jessen, MP Kladde (2006) <i>DNA Structure, Chromatin and Gene Expression.</i> 101-120<br/>

http://publicationslist.org/walter.j.jessen/refid7 2009-02-05T03:34:35Z

Cytosine-5 DNA methyltransferases (C5 DMTases) are effective reagents for analyzing chromatin and footprinting DNA-bound factors in vivo. Cytosine methylation in accessible regions is assayed positively by the PCR-based technique of bisulfite sequencing. In this article, we outline two complementary uses for the DNA methyltransferase CviPI (M.CviPI, GC specificity) in probing chromatin organizatio...<br/><br/>Walter J Jessen, Archana Dhasarathy, Scott A Hoose, Christopher D Carvin, April L Risinger, Michael P Kladde (2004) <i>Methods</i> 33: 1 68-80<br/>

http://publicationslist.org/walter.j.jessen/refid8 2009-02-05T03:35:41Z

We report a technique, named targeted gene methylation (TAGM), for identifying in vivo protein-binding sites in chromatin. M.CviPI, a cytosine-5 DNA methyltransferase recognizing GC sites, is fused to a DNA-binding factor enabling simultaneous detection of targeted methylation, factor footprints, and chromatin structural changes by bisulfite genomic sequencing. Using TAGM with the yeast transactiv...<br/><br/>Christopher D Carvin, Archana Dhasarathy, Laurie B Friesenhahn, Walter J Jessen, Michael P Kladde (2003) <i>Proc Natl Acad Sci U S A</i> 100: 13 7743-7748<br/>