http://publicationslist.org/data/y.yu/atom.xml Yingjie Yuhttp://publicationslist.org/y.yu$basepathfavicon.icoRecent additions to Yingjie Yu's PublicationsList.org pagehttp://publicationslist.org/publications.png2011-05-11T19:27:14Z http://publicationslist.org/y.yu/refid4 2011-05-11T19:21:14Z

Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal cancer remains high, highlighting the need for improved therapies. Numerous studies have demonstrated increased activation of EGFR and its family members (EGFRs), IGF-1R as well as c-Src in colorectal cancer. The current study was undertake...<br/><br/>Jyoti Nautiyal, Sanjeev Banerjee, Shailender S Kanwar, Yingjie Yu, Bhaumik B Patel, Fazlul H Sarkar, Adhip P N Majumdar (2011) <i>Int J Cancer</i> <i></i> <i></i> 128: 4 951-961<br/>

http://publicationslist.org/y.yu/refid1 2011-05-11T19:21:14Z

Recurrence of colon cancer, which affects nearly 50% of patients treated by conventional therapeutics, is thought to be due to re-emergence of chemotherapy-resistant cancer stem/stem-like cells (CSCs). Therefore, development of therapeutic strategies for targeted elimination of CSCs would be a novel strategy. The current study examines whether difluorinated-curcumin (CDF), a novel analog of the di...<br/><br/>Shailender Singh Kanwar, Yingjie Yu, Jyoti Nautiyal, Bhaumik B Patel, Subhash Padhye, Fazlul H Sarkar, Adhip P N Majumdar (2011) <i>Pharm Res</i> <i></i> <i></i> 28: 4 827-838<br/>

http://publicationslist.org/y.yu/refid6 2011-05-11T19:21:14Z

The intestinal epithelium is subjected to repetitive deformation during normal gut function by peristalsis and villous motility. In vitro, cyclic strain promotes intestinal epithelial proliferation and induces an absorptive phenotype characterized by increased dipeptidyl dipeptidase (DPPIV) expression. Schlafen 3 is a novel gene recently associated with cellular differentiation. We sought to evalu...<br/><br/>Lisi Yuan, Yingjie Yu, Matthew A Sanders, Adhip P N Majumdar, Marc D Basson (2010) <i>Am J Physiol Gastrointest Liver Physiol</i> <i></i> <i></i> 298: 6 G994-G1003<br/>

http://publicationslist.org/y.yu/refid5 2011-05-11T19:21:14Z

Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion and progression of carcinogenesis. 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but produces an incomplete response resulting in survival of cells (chemo-surviving cells) that may lead to cancer recurrence. The present investigation...<br/><br/>Bhaumik B Patel, Deepshika Gupta, Althea A Elliott, Vivek Sengupta, Yingjie Yu, Adhip P N Majumdar (2010) <i>Anticancer Res</i> <i></i> <i></i> 30: 2 319-325<br/>

http://publicationslist.org/y.yu/refid3 2011-05-11T19:21:14Z

Many solid tumors, including breast cancer, show increased activation of several growth factor receptors, specifically epidermal growth factor receptor (EGFR) and its family members as well as c-Src, a nonreceptor tyrosine kinase that promotes proliferation, inhibits apoptosis, and induces metastasis. We hypothesize that inhibition of c-Src and EGFRs will be an effective therapeutic strategy for t...<br/><br/>Jyoti Nautiyal, Yingjie Yu, Amro Aboukameel, Shailender S Kanwar, Jayanta K Das, Jianhua Du, Bhaumik B Patel, Fazlul H Sarkar, Arun K Rishi, Ramzi M Mohammad, Adhip P N Majumdar (2010) <i>Mol Cancer Ther</i> <i></i> <i></i> 9: 6 1503-1514<br/>

http://publicationslist.org/y.yu/refid2 2011-05-11T19:21:14Z

Recent evidence suggests that epithelial cancers, including colorectal cancer are driven by a small sub-population of self-renewing, multi-potent cells termed cancer stem cells (CSCs) which are thought to be responsible for recurrence of cancer. One of the characteristics of CSCs is their ability to form floating spheroids under anchorage-independent conditions in a serum-free defined media. The c...<br/><br/>Shailender S Kanwar, Yingjie Yu, Jyoti Nautiyal, Bhaumik B Patel, Adhip P N Majumdar (2010) <i>Mol Cancer</i> <i></i> <i></i> 9: <br/>

http://publicationslist.org/y.yu/refid9 2011-05-11T19:21:14Z

Schlafen-3 (Slfn-3), a novel gene, has been shown to be a negative regulator of proliferation. The current investigation was undertaken to determine whether Slfn-3 might play a role in regulating cellular differentiation. Butyric acid, a short chain fatty acid, which induced differentiation of intestinal cells as evidenced by increased alkaline phosphatase (ALP) activity in the rat small intestina...<br/><br/>Vaishali B Patel, Yingjie Yu, Jayanta K Das, Bhaumik B Patel, Adhip P N Majumdar (2009) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 388: 4 752-756<br/>

http://publicationslist.org/y.yu/refid10 2011-05-11T19:21:14Z

Although aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa of Fischer 344 rats, the regulatory mechanisms are poorly understood. Gene expression profiling (Illumina platform) was carried out in freshly isolated colonic mucosal cells from young (4-6 mo old) and aged (22-24 mo old) Fischer 344 rats. Sixty-six genes were differentially expressed in the col...<br/><br/>Bhaumik B Patel, Yingjie Yu, Jianhua Du, Arun K Rishi, Fazlul H Sarkar, Adi L Tarca, Anil Wali, Adhip P N Majumdar (2009) <i>Am J Physiol Gastrointest Liver Physiol</i> <i></i> <i></i> 296: 4 G955-G962<br/>

http://publicationslist.org/y.yu/refid8 2011-05-11T19:21:14Z

Development and progression of many malignancies, including colorectal cancer, are associated with activation of multiple signaling pathways. Therefore, inhibition of these signaling pathways with noncytotoxic natural products represents a logical preventive and/or therapeutic approach for colon cancer. Curcumin and resveratrol, both of which inhibit the growth of transformed cells and colon carci...<br/><br/>Adhip P N Majumdar, Sanjeev Banerjee, Jyoti Nautiyal, Bhaumik B Patel, Vaishali Patel, Jianhua Du, Yingjie Yu, Althea A Elliott, Edi Levi, Fazlul H Sarkar (2009) <i>Nutr Cancer</i> <i></i> <i></i> 61: 4 544-553<br/>

http://publicationslist.org/y.yu/refid16 2011-05-11T19:24:52Z

It is becoming increasingly evident that cancer stem cells play a vital role in development and progression of cancers and relapse following chemotherapy. The present study examines the presence of cancer stem-like cells (CSC) in adenomatous polyps and in normal appearing colonic mucosa in humans during aging. The number of polyps was found to increase linearly with advancing age (r(2)=0.92, p<0.0...<br/><br/>Bhaumik B Patel, Yingjie Yu, Jianhua Du, Edi Levi, Phillip A Phillip, Adhip P N Majumdar (2009) <i>Biochem Biophys Res Commun</i> <i></i> <i></i> 378: 3 344-347<br/>

http://publicationslist.org/y.yu/refid7 2011-05-11T19:21:14Z

5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics but with limited success. This could partly be due to the enrichment of cancer stem cells (CSCs) that are resistant to conventional chemotherapy. Therefore, validation of a nontoxic agent that can either cause reversal of chemoresistance or promote the killing of CSCs would be highly...<br/><br/>Yingjie Yu, Shailender S Kanwar, Bhaumik B Patel, Jyoti Nautiyal, Fazlul H Sarkar, Adhip Pn Majumdar (2009) <i>Transl Oncol</i> <i></i> <i></i> 2: 4 321-328<br/>

http://publicationslist.org/y.yu/refid17 2011-05-11T19:24:52Z

Because the colonic mucosa is in direct contact with digesta, luminal exposure to potentially carcinogenic or chemopreventive agents may be important in colorectal carcinogenesis, independently of the effects of systemic exposure through the circulation. To date, few biomarkers for luminal exposure have been identified, and isolation of reasonably good quality fecal human RNA remains difficult. In...<br/><br/>Ying Jie Yu, Adhip P N Majumdar, Jordan M Nechvatal, Jeffrey L Ram, Marc D Basson, Lance K Heilbrun, Ikuko Kato (2008) <i>Cancer Epidemiol Biomarkers Prev</i> <i></i> <i></i> 17: 2 455-458<br/>

http://publicationslist.org/y.yu/refid19 2011-05-11T19:24:52Z

Curcumin (diferuloylmethane), which has been shown to inhibit growth of transformed cells, has no discernible toxicity and achieves high levels in colonic mucosa. 5-fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but with limited success. The present investigation was, therefore, undertaken to examine whether curcumin in combinatio...<br/><br/>Bhaumik B Patel, Radha Sengupta, Sadia Qazi, Hetal Vachhani, Yingjie Yu, Arun K Rishi, Adhip P N Majumdar (2008) <i>Int J Cancer</i> <i></i> <i></i> 122: 2 267-273<br/>

http://publicationslist.org/y.yu/refid20 2011-05-11T19:24:52Z

Deregulated signaling by the epidermal growth factor receptor family of proteins is encountered in human malignancies including breast cancer. Cell cycle and apoptosis-regulatory protein-1 (CARP-1), a novel, perinuclear phosphoprotein, is a regulator of apoptosis signaling by epidermal growth factor receptors. CARP-1 expression is diminished in human breast cancers, and correlates inversely with h...<br/><br/>Liyue Zhang, Edi Levi, Pralay Majumder, Yingjie Yu, Amro Aboukameel, Jianhua Du, Hu Xu, Ramzi Mohammad, James S Hatfield, Anil Wali, Volkan Adsay, Adhip P N Majumdar, Arun K Rishi (2007) <i>Mol Cancer Ther</i> <i></i> <i></i> 6: 5 1661-1672<br/>

http://publicationslist.org/y.yu/refid18 2011-05-11T19:24:52Z

Although the regulatory mechanisms for the age-related rise in proliferation and reduction in apoptosis in the colonic mucosa are yet to be fully delineated, we have demonstrated that these events are associated with increased expression and activation of epithelial growth factor receptor (EGFR)/ErbB-1 and some of its receptor family members (EGFRs), indicating their involvement in these processes...<br/><br/>Adhip P N Majumdar, Jianhua Du, Yingjie Yu, Hu Xu, Edi Levi, Bhaumik B Patel, Arun K Rishi (2007) <i>Am J Physiol Gastrointest Liver Physiol</i> <i></i> <i></i> 293: 6 G1215-G1222<br/>

http://publicationslist.org/y.yu/refid21 2011-05-11T19:24:52Z

Activation of the epidermal growth factor receptor (EGFR) and/or its family member(s) stimulates many processes of carcinogenesis, including cell invasion and the formation of new blood vessels, events that are critically involved in angiogenesis. Interference with the activation of EGFRs, therefore, represents a promising strategy for the development of novel and selective anticancer therapies. P...<br/><br/>Arun K Rishi, Rakesh Parikh, Anil Wali, Lukasz Durko, Liyue Zhang, Yingjie Yu, Adhip P N Majumdar (2006) <i>Anticancer Res</i> <i></i> <i></i> 26: 2A 1029-1037<br/>

http://publicationslist.org/y.yu/refid22 2011-05-11T19:24:52Z

CARP-1, a novel apoptosis inducer, regulates apoptosis signaling by diverse agents, including adriamycin and growth factors. Epidermal growth factor receptor (EGFR)-related protein (ERRP), a pan-ErbB inhibitor, inhibits EGFR and stimulates apoptosis. Treatments of cells with ERRP or Iressa (an EGFR tyrosine kinase inhibitor) results in elevated CARP-1 levels, whereas antisense-dependent depletion ...<br/><br/>Arun K Rishi, Liyue Zhang, Yingjie Yu, Yan Jiang, Jyoti Nautiyal, Anil Wali, Joseph A Fontana, Edi Levi, Adhip P N Majumdar (2006) <i>J Biol Chem</i> <i></i> <i></i> 281: 19 13188-13198<br/>

http://publicationslist.org/y.yu/refid23 2011-05-11T19:24:52Z

Inactivation of epidermal growth factor receptor (EGFR) family members represents a promising strategy for the development of selective therapies against epithelial cancers. Current anti-EGFR therapies, such as cetuximab (Erbitux), gefitinib (Iressa), or trastuzumab (Herceptin), target EGFR or HER-2 but not both. Because solid tumors express different EGFRs, identification of inhibitor(s), targeti...<br/><br/>Hu Xu, Yingjie Yu, Dorota Marciniak, Arun K Rishi, Fazlul H Sarkar, Omer Kucuk, Adhip P N Majumdar (2005) <i>Mol Cancer Ther</i> <i></i> <i></i> 4: 3 435-442<br/>

http://publicationslist.org/y.yu/refid24 2011-05-11T19:24:52Z

CD437, a novel retinoid, causes cell cycle arrest and apoptosis in a number of cancer cells including human breast carcinoma (HBC) by utilizing an undefined retinoic acid receptor/retinoid X receptor-independent mechanism. To delineate mediators of CD437 signaling, we utilized a random antisense-dependent functional knockout genetic approach. We identified a cDNA that encodes approximately 130-kDa...<br/><br/>Arun K Rishi, Liyue Zhang, Madanamohan Boyanapalli, Anil Wali, Ramzi M Mohammad, Yingjie Yu, Joseph A Fontana, James S Hatfield, Marcia I Dawson, Adhip P N Majumdar, Uwe Reichert (2003) <i>J Biol Chem</i> <i></i> <i></i> 278: 35 33422-33435<br/>

http://publicationslist.org/y.yu/refid25 2011-05-11T19:24:52Z

Epidermal growth factor receptor is frequently implicated in epithelial cancers and is, therefore, being considered as a potential target for therapy. Recently, we reported the isolation and characterization of epidermal growth factor receptor-related protein, a negative regulator of epidermal growth factor receptor. To discern whether epidermal growth factor receptor-related protein could be an e...<br/><br/>Dorota J Marciniak, Lathika Moragoda, Ramzi M Mohammad, Yingjie Yu, Kiran K Nagothu, Amro Aboukameel, Fazlul H Sarkar, Volkan N Adsay, Arun K Rishi, Adhip P n Majumdar (2003) <i>Gastroenterology</i> <i></i> <i></i> 124: 5 1337-1347<br/>

http://publicationslist.org/y.yu/refid11 2011-05-11T19:24:09Z

Although epidermal growth factor receptor (EGFR) plays a key role in regulating cell proliferation, differentiation, and transformation in many tissues, little is known about the factor(s) that may modulate its function. We have isolated a cDNA clone from the rat gastroduodenal mucosa whose full length revealed 1,958 bp that contained 227 bp of 5'-untranslated region (UTR) and an open-reading fram...<br/><br/>Y Yu, A K Rishi, J R Turner, D Liu, E D Black, J A Moshier, A P Majumdar (2001) <i>Am J Physiol Cell Physiol</i> <i></i> <i></i> 280: 5 C1083-C1089<br/>

http://publicationslist.org/y.yu/refid13 2011-05-11T19:24:09Z

Although in Fischer 344 rats aging is found to be associated with increased gastric mucosal proliferative activity, little is known about specific changes in the regulatory mechanisms of this process. To determine whether changes in cell cycling events could partly contribute to the age-related rise in gastric mucosal proliferative activity, the present investigation examines changes in cyclin-dep...<br/><br/>Z Q Xiao, Y Yu, A Khan, R Jaszewski, M N Ehrinpreis, A P Majumdar (1999) <i>Am J Physiol</i> <i></i> <i></i> 277: 5 Pt 1 G929-G934<br/>

http://publicationslist.org/y.yu/refid12 2011-05-11T19:24:09Z

To study the role of EGF-R in small intestinal adaptation to hemorrhage and I/R, anesthetized rabbits were implanted aseptically with arterial and venous catheters and bilateral renal artery Doppler flow probes and silastic occluders and allowed to recover. Rabbits were then randomly assigned to one of six groups: time control; hemorrhage (22.5 mL/kg) and 2.5 hours of renal occlusion (hemorrhage p...<br/><br/>J L Sondeen, M A Dubick, Y Yu, A P Majumdar (1999) <i>J Lab Clin Med</i> <i></i> <i></i> 134: 6 641-648<br/>

http://publicationslist.org/y.yu/refid14 2011-05-11T19:24:09Z

Aging is associated with decreased reparative ability of the gastric mucosa. Our recent data suggest a role for epidermal growth factor receptor (EGFR) in the mucosal reparative processes. Thus we examined changes in EGFR tyrosine kinase activity as well as expression and subcellular localization of EGFR and its ligand transforming growth factor-alpha (TGF-alpha) in the gastric mucosa of young (4-...<br/><br/>L Liu, J R Turner, Y Yu, A J Khan, R Jaszewski, S E Fligiel, A P Majumdar (1998) <i>Am J Physiol</i> <i></i> <i></i> 275: 5 Pt 1 G943-G950<br/>

http://publicationslist.org/y.yu/refid15 2011-05-11T19:24:09Z

Although in Fischer-344 rats aging is found to be associated with increased gastric mucosal proliferative activity, little is known about the intracellular events that regulate this process. The present investigation examines the age-related changes in gastric mucosal tyrosine kinase activity and expression of epidermal growth factor receptor(EGFR) and its structural and functional analog p185c-er...<br/><br/>J Tureaud, F H Sarkar, S E Fligiel, S Kulkarni, R Jaszewski, K Reddy, Y Yu, A P Majumdar (1997) <i>Am J Physiol</i> <i></i> <i></i> 273: 2 Pt 1 G389-G398<br/>