http://publicationslist.org/data/y.z.zhang/atom.xml Yiguo Zhanghttp://publicationslist.org/y.z.zhang$basepathfavicon.icoRecent additions to Yiguo Zhang's PublicationsList.org pagehttp://publicationslist.org/publications.png2014-04-05T17:52:19Z http://publicationslist.org/y.z.zhang/refid33 2014-04-05T17:51:51Z

The membrane-bound Nrf1 transcription factor regulates critical homeostatic and developmental genes. The conserved N-terminal homology box 1 (NHB1) sequence in Nrf1 targets the cap'n'collar (CNC) basic basic-region leucine zipper (bZIP) factor to the endoplasmic reticulum (ER), but it is unknown how its activity is controlled topologically within membranes. Herein, we report a hitherto unknown mec...<br/><br/>Yiguo Zhang, Yonggang Ren, Shaojun Li, John D Hayes (2014) <i>PloS one</i> <i></i> <i></i> 9: 4 1-17; e93458<br/>

http://publicationslist.org/y.z.zhang/refid32 2014-01-29T12:12:15Z

Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outgrowth of castration resistant prostate cancer (CRPC). In prostate cancer (PCa) cells, ADT may enhance AR activity through induction of oxidative stress. Herein, we investigated the roles of Nrf1 and Nrf2, transcription factors that regulate antioxidant gene expression, on hormone-mediated AR transac...<br/><br/>Michelle A Schultz, Sharika S Hagan, Amrita Datta, Yiguo Zhang, Michael L Freeman, Suresh C Sikka, Asim B Abdel-Mageed, Debasis Mondal (2014) <i>PloS one</i> <i></i> <i></i> 9: 1 <br/>

http://publicationslist.org/y.z.zhang/refid30 2013-07-08T05:13:49Z

The integral membrane-bound Nrf1 transcription factor fulfils important functions in maintaining cellular homeostasis and organ integrity, but how it is controlled vectorially is unknown. Herein, creative use of Gal4-based reporter assays with protease protection assays (GRAPPA), and double fluorescence protease protection (dFPP), reveals that the membrane-topogenic vectorial behaviour of Nrf1 dic...<br/><br/>Yiguo Zhang, John D Hayes (2013) <i>Scientific reports_Nature.com</i> <i></i> <i></i> 3: 2006 1-16<br/>

http://publicationslist.org/y.z.zhang/refid31 2014-01-07T21:26:39Z

ds, a subclass of polyphenols, are abundant components of fruit and vegetables, prevalent in the diet and having an inverse association with the incidence of various degenerative diseases and cancer. Mechanisms underlying the beneficial effects of flavonoids on the human health are being investigated worldwide. Flavonoids have been found to reduce the risk of carcinogenesis by blocking the initiat...<br/><br/>H Xiao, F Lü, D Steward, Y Zhang (2013) <i>Current Chemical Biology</i> 7: 2 151-176<br/>

http://publicationslist.org/y.z.zhang/refid28 2013-09-13T18:34:59Z

Identification of regulatable mechanisms by which transcription factor NF-E2 p45-related factor 2 (Nrf2) is repressed will allow strategies to be designed that counter drug resistance associated with its upregulation in tumours that harbour somatic mutations in Kelch-like ECH-associated protein-1 (Keap1), a gene that encodes a joint adaptor and substrate receptor for the Cul3-Rbx1/Roc1 ubiquitin l...<br/><br/>S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, J D Hayes (2012-3) <i>Oncogene</i> <i></i> <i></i> 32: 32 3765-3781<br/>

http://publicationslist.org/y.z.zhang/refid26 2011-05-25T19:19:07Z

Background: Epidemiological statistics has shown that there are approximately 1.2 million new cases of lung cancer diagnosed every year and the death rate of these patients is 17.8%. Earlier diagnosis is key to promote the five-year survival rate of these cancer patients. Some tumor markers have been found to be valuable for earlier diagnosis, but a single marker has limitation in its sensitivi...<br/><br/>Yongjun Wu, Yiming Wu, Jing Wang, Zhen Yan, Lingbo Qu, Bingren Xiang, Yiguo Zhang (2011) <i>Expert Systems with Applications</i> 38: 11329-1134<br/>

http://publicationslist.org/y.z.zhang/refid27 2012-01-08T11:24:59Z

It is clear that solar UV irradiation is a crucial environmental factor resulting in skin diseases partially through activation of cell signaling toward altered gene expression and reprogrammed protein translation. Such a key translational control mechanism is executed by the eukaryotic initiation factor 2α subunit (eIF2α) and the downstream events provoked by phosphorylation of eIF2α at Ser(51...<br/><br/>Julia Li Zhong, Li Yang, Fenglin Lü, Han Xiao, Ruoqi Xu, Lijuan Wang, Feng Zhu, Yiguo Zhang (2011) <i>Photochem Photobiol</i> <i></i> <i></i> 87: 5 1092-1104<br/>

http://publicationslist.org/y.z.zhang/refid25 2011-05-25T19:08:52Z

Nrf1 [NF-E2 (nuclear factor-erythroid 2)-related factor 1] is a CNC (cap'n'collar) bZIP (basic-region leucine zipper) transcription factor that is tethered to ER (endoplasmic reticulum) and nuclear envelope membranes through its N-terminal signal peptide (residues 1-30). Besides the signal peptide, amino acids 31-90 of Nrf1 also negatively regulate the CNC-bZIP factor. In the present study we have...<br/><br/>Yiguo Zhang, John D Hayes (2010) <i>Biochem J</i> <i></i> <i></i> 430: 3 497-510<br/>

http://publicationslist.org/y.z.zhang/refid1 2009-04-18T07:35:10Z

In rat liver RL-34 cells, endogenous Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is localized in the ER (endoplasmic reticulum) where it exists as a glycosylated protein. Electron microscopy has demonstrated that ectopic Nrf1 in COS-1 cells is located in the ER and the NE (nuclear envelope). Subcellular fractionation, together with a membrane proteinase protection assay, reveale...<br/><br/>Yiguo Zhang, John M Lucocq, John D Hayes (2009) <i>Biochem J</i> <i></i> <i></i> 418: 2 293-310<br/>

http://publicationslist.org/y.z.zhang/refid24 2009-04-18T07:35:10Z

Transcription factor Nrf3 (NF-E2 p45-related factor 3) is targeted to the endoplasmic reticulum (ER). Mouse Nrf3 is subject to proteolysis, Asn glycosylation, and deglycosylation reactions. It is synthesized as a approximately 96-kDa protein that is subsequently converted into isoforms of approximately 90, 80, and 70 kDa. In the ER, the approximately 90-kDa glycoprotein is predominant and gives ri...<br/><br/>Yiguo Zhang, Akira Kobayashi, Masayuki Yamamoto, John D Hayes (2009) <i>J Biol Chem</i> <i></i> <i></i> 284: 5 3195-3210<br/>

http://publicationslist.org/y.z.zhang/refid3 2008-11-25T19:13:48Z

Double-stranded RNA-dependent protein kinase R (PKR) has been implicated in anti-viral (antitumor) and apoptotic responses. PKR is activated by extracellular stresses and phosphorylates the alpha subunit of protein synthesis initiation factor eIF2, thereby inhibiting protein synthesis and impeding virus multiplication. Phosphorylation of eIF2alpha in mammalian cells has been shown to be increased ...<br/><br/>Tatyana A Zykova, Feng Zhu, Yiguo Zhang, Ann M Bode, Zigang Dong (2007) <i>Carcinogenesis</i> <i></i> <i></i> 28: 7 1543-1551<br/>

http://publicationslist.org/y.z.zhang/refid2 2008-11-25T19:13:48Z

Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is negatively controlled by its NTD (N-terminal domain) that lies between amino acids 1 and 124. This domain contains a leucine-rich sequence, called NHB1 (N-terminal homology box 1; residues 11-30), which tethers Nrf1 to the ER (endoplasmic reticulum). Electrophoresis resolved Nrf1 into two major bands of approx. 95 and 120 kDa. The 1...<br/><br/>Yiguo Zhang, John M Lucocq, Masayuki Yamamoto, John D Hayes (2007) <i>Biochem J</i> <i></i> <i></i> 408: 2 161-172<br/>

http://publicationslist.org/y.z.zhang/refid5 2008-11-25T19:13:48Z

The oncoprotein c-Jun is a component of the activator protein-1 transcription factor complex, which is involved in cellular proliferation, transformation, and death. The stabilization of c-Jun is critically important for its function. The phosphorylation of c-Jun by c-Jun NH(2)-terminal kinase 1 and extracellular signal-regulated protein kinases reduces c-Jun ubiquitination resulting in increased ...<br/><br/>Feng Zhu, Bu Young Choi, Wei-Ya Ma, Zhongliang Zhao, Yiguo Zhang, Yong Yeon Cho, Hong Seok Choi, Akira Imamoto, Ann M Bode, Zigang Dong (2006) <i>Cancer Res</i> <i></i> <i></i> 66: 11 5729-5736<br/>

http://publicationslist.org/y.z.zhang/refid4 2008-11-25T19:13:48Z

Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) and Nrf2 regulate ARE (antioxidant response element)-driven genes. At its N-terminal end, Nrf1 contains 155 additional amino acids that are absent from Nrf2. This 155-amino-acid polypeptide includes the N-terminal domain (NTD, amino acids 1-124) and a region (amino acids 125-155) that is part of acidic domain 1 (amino acids 125-295). W...<br/><br/>Yiguo Zhang, Dorothy H Crouch, Masayuki Yamamoto, John D Hayes (2006) <i>Biochem J</i> <i></i> <i></i> 399: 3 373-385<br/>

http://publicationslist.org/y.z.zhang/refid6 2008-11-25T19:13:48Z

The tumor suppressor p53 protein is one of the most highly connected nodes in cellular signal transduction pathways and acts as a central regulatory switch in networks controlling cell proliferation and apoptosis. It is involved in the activation of genes that maintain control over cellular responses to DNA errors such as DNA repair, chromosomal recombination, and chromosome segregation. Here we s...<br/><br/>Yong-Yeon Cho, Zhiwei He, Yiguo Zhang, Hong Seok Choi, Feng Zhu, Bu Young Choi, Bong Seok Kang, Wei-Ya Ma, Ann M Bode, Zigang Dong (2005) <i>Cancer Res</i> <i></i> <i></i> 65: 9 3596-3603<br/>

http://publicationslist.org/y.z.zhang/refid7 2008-11-25T19:13:48Z

Signal transducers and activators of transcription (STATs) play a critical role in signal transduction pathways. STATs are a family of cytoplasmic proteins with roles as signal messengers and transcription factors that participate in normal cellular responses to cytokines and growth factors. Phosphorylation of STAT1 at Ser727 is essential for its activation and occurs in response to stress signals...<br/><br/>Tatyana A Zykova, Yiguo Zhang, Feng Zhu, Ann M Bode, Zigang Dong (2005) <i>Carcinogenesis</i> <i></i> <i></i> 26: 2 331-342<br/>

http://publicationslist.org/y.z.zhang/refid9 2008-11-25T19:13:48Z

Phosphorylation at Ser727 in signal transducer and activator of transcription 1 (STAT1) is essential for its activation and signal transduction. However, the upstream kinases responsible for phosphorylating Ser727 are still elusive. Here, we provide evidence showing that UVA-induced mitogen-activated protein kinase (MAPK) signaling pathways lead to STAT1 Ser727 phosphorylation. Our experimental re...<br/><br/>Yiguo Zhang, Yong-Yeon Cho, Brandon L Petersen, Feng Zhu, Zigang Dong (2004) <i>Carcinogenesis</i> <i></i> <i></i> 25: 7 1165-1175<br/>

http://publicationslist.org/y.z.zhang/refid8 2008-11-25T19:13:48Z

Activating transcription factor 2 (ATF2) has been shown to regulate gene expression in the cellular response to environmental stresses such as ultraviolet (UV) irradiation. However, the signal transduction mechanism of ATF2 activation by UV is not as yet completely understood. In the present study, we provide evidence showing that UVC-stimulated phosphorylation of ATF2 (Thr71) was to varying degre...<br/><br/>Feng Zhu, Yiguo Zhang, Ann M Bode, Zigang Dong (2004) <i>Carcinogenesis</i> <i></i> <i></i> 25: 10 1847-1852<br/>

http://publicationslist.org/y.z.zhang/refid11 2008-11-25T19:19:44Z

Phosphorylation at Ser(727) is known to be required for complete activation of STAT3 by diverse stimuli including UV irradiation, but the kinase(s) responsible for phosphorylating STAT3 (Ser(727)) is still not well discerned. In the present study, we observed that activation of ATM is required for a UVA-stimulated increase in Ser(727) phosphorylation of STAT3 as well as in activation and phosphory...<br/><br/>Yiguo Zhang, Yong-Yeon Cho, Brandon L Petersen, Ann M Bode, Feng Zhu, Zigang Dong (2003) <i>J Biol Chem</i> <i></i> <i></i> 278: 15 12650-12659<br/>

http://publicationslist.org/y.z.zhang/refid10 2008-11-25T19:13:48Z

Recently, blockage of p53-dependent transcriptional activation and apoptosis by pifithrin-alpha (PFTalpha) has been reported to be useful for reducing the side effects of cancer therapy and the compound is thus thought to be a specific inhibitor of p53 [Komarov et al., Science 1999;285:1733-1737]. Here, we found that PFTalpha did not inhibit UVB- or doxorubicin (Dox)-stimulated p53-mediated transc...<br/><br/>Akira Kaji, Yiguo Zhang, Masaaki Nomura, Ann M Bode, Wei-Ya Ma, Qing-Bai She, Zigang Dong (2003) <i>Mol Carcinog</i> <i></i> <i></i> 37: 3 138-148<br/>

http://publicationslist.org/y.z.zhang/refid13 2008-11-25T19:19:44Z

Cyclooxygenases (COX) are rate-limiting enzymes that catalyze the conversion of arachidonic acid to prostaglandins, which are involved in many physiological and pathophysiological responses. COX-2, one of two isoforms of COX, was recently found to play an important role in carcinogenesis in many cell and tissue types. COX-2 inhibitors, which belong to the family of nonsteroidal anti-inflammatory d...<br/><br/>Guangming Liu, Wei-Ya Ma, Ann M Bode, Yiguo Zhang, Zigang Dong (2003) <i>J Biol Chem</i> <i></i> <i></i> 278: 4 2124-2130<br/>

http://publicationslist.org/y.z.zhang/refid12 2008-11-25T19:19:44Z

Arsenite is known to be an environmental human carcinogen. However, the mechanism of action of this compound in skin carcinogenesis is not completely clear. Here, we provide evidence that arsenite can induce phosphorylation of histone H3 at serine 10 in a time- and dose-dependent manner in JB6 Cl 41 cells. Arsenite induces phosphorylation of Akt1 at serine 473 and increases Akt1 activity. A domina...<br/><br/>Zhiwei He, Wei-Ya Ma, Guangming Liu, Yiguo Zhang, Ann M Bode, Zigang Dong (2003) <i>J Biol Chem</i> <i></i> <i></i> 278: 12 10588-10593<br/>

http://publicationslist.org/y.z.zhang/refid16 2008-11-25T19:21:34Z

Solar UVA, but not UVC, reaches the earth's surface and therefore is an important etiological factor for the induction of human skin cancer. ATM kinase is an important regulator of cell survival and cell cycle checkpoints. Here, we observe that UVA, unlike UVC, triggers ATM kinase activity, and the activation may occur through reactive oxygen species produced after irradiation of cells with UVA. W...<br/><br/>Yiguo Zhang, Wei-Ya Ma, Akira Kaji, Ann M Bode, Zigang Dong (2002) <i>J Biol Chem</i> <i></i> <i></i> 277: 5 3124-3131<br/>

http://publicationslist.org/y.z.zhang/refid14 2008-11-25T19:21:34Z

Resveratrol, a constituent of grapes and other foods, is one of the most promising agents for cancer prevention. In a previous study, we showed that the antitumor activity of resveratrol occurs through extracellular signal-regulated protein kinases (ERKs) and p38 kinase-mediated p53 activation. In this study, we also determined that c-jun NH(2)-terminal kinases (JNKs) are involved in resveratrol-i...<br/><br/>Qing-Bai She, Chuanshu Huang, Yiguo Zhang, Zigang Dong (2002) <i>Mol Carcinog</i> <i></i> <i></i> 33: 4 244-250<br/>

http://publicationslist.org/y.z.zhang/refid15 2008-11-25T19:21:34Z

In resting cells, eIF4E-binding protein 1 (4E-BP1) binds to the eukaryotic initiation factor-4E (eIF-4E), preventing formation of a functional eIF-4F complex essential for cap-dependent initiation of translation. Phosphorylation of 4E-BP1 dissociates it from eIF-4E, relieving the translation block. Studies suggested that insulin- or growth factor-induced 4E-BP1 phosphorylation is mediated by phosp...<br/><br/>Guangming Liu, Yiguo Zhang, Ann M Bode, Wei-Ya Ma, Zigang Dong (2002) <i>J Biol Chem</i> <i></i> <i></i> 277: 11 8810-8816<br/>

http://publicationslist.org/y.z.zhang/refid17 2008-11-25T19:21:34Z

Most of the signal pathways involved in ultraviolet (UV)-induced skin carcinogenesis are thought to originate at plasma membrane receptors. However, UVA-induced signal transduction to downstream ribosomal protein S6 kinases, p70(S6K) and p90(RSK), is not well understood. In this report, we show that UVA stimulation of the epidermal growth factor receptor (EGFR) may lead to activation of p70(S6K)/p...<br/><br/>Y Zhang, Z Dong, A M Bode, W Y Ma, N Chen (2001) <i>DNA Cell Biol</i> <i></i> <i></i> 20: 12 769-779<br/>

http://publicationslist.org/y.z.zhang/refid22 2008-11-25T19:21:34Z

UVA exposure plays an important role in the etiology of skin cancer. The family of p90-kDa ribosomal S6 kinases (p90(RSK)/MAPKAP-K1) are activated via phosphorylation. In this study, results show that UVA-induced phosphorylation of p90(RSK) at Ser(381) through ERKs and JNKs, but not p38 kinase pathways. We provide evidence that UVA-induced p90(RSK) phosphorylation and kinase activity were time- an...<br/><br/>Y Zhang, S Zhong, Z Dong, N Chen, A M Bode, W Ma (2001) <i>J Biol Chem</i> <i></i> <i></i> 276: 18 14572-14580<br/>

http://publicationslist.org/y.z.zhang/refid23 2008-11-25T19:21:34Z

Activator protein-1 (AP-1), a dimeric complex consisting of proteins encoded by the jun and fos gene families, is a transcription factor induced by a variety of signals including those eliciting proliferation, differentiation, and neoplastic transformation. Although AP-1 has been widely studied in the last decade, physiological levels of AP-1 in different tissues are unclear. In the present study,...<br/><br/>S P Zhong, W Y Ma, J A Quealy, Y Zhang, Z Dong (2001) <i>Am J Physiol Regul Integr Comp Physiol</i> <i></i> <i></i> 280: 2 R376-R381<br/>

http://publicationslist.org/y.z.zhang/refid21 2008-11-25T19:21:34Z

The sphingomyelin-ceramide pathway is an evolutionarily conserved ubiquitous signal transduction system that regulates many cell functions including apoptosis. Sphingomyelin (SM) is hydrolyzed to ceramide by different sphingomyelinases. Ceramide serves as a second messenger in mediating cellular effects of cytokines and stress. In this study, we find that acid sphingomyelinase (SMase) activity was...<br/><br/>Y Zhang, P Mattjus, P C Schmid, Z Dong, S Zhong, W Y Ma, R E Brown, A M Bode, H H Schmid (2001) <i>J Biol Chem</i> <i></i> <i></i> 276: 15 11775-11782<br/>

http://publicationslist.org/y.z.zhang/refid20 2008-11-25T19:21:34Z

Histone H3 phosphorylation is related closely to chromatin remodeling and chromosome condensation. H3 phosphorylation at serine 28 is coupled with mitotic chromosome condensation in diverse mammalian cell lines. However, the pathway that mediates phosphorylation of H3 at serine 28 is unknown. In the present study, ERK1, ERK2, or p38 kinase strongly phosphorylated H3 at serine 28 in vitro. JNK1 or ...<br/><br/>S Zhong, Y Zhang, C Jansen, H Goto, M Inagaki, Z Dong (2001) <i>J Biol Chem</i> <i></i> <i></i> 276: 16 12932-12937<br/>

http://publicationslist.org/y.z.zhang/refid19 2008-11-25T19:21:34Z

Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well understood. Here, we observed that UVA induces phosphorylation and activation of p70(S6K). Further, UVA-stimulated p70(S6K) ...<br/><br/>Y Zhang, Z Dong, M Nomura, S Zhong, N Chen, A M Bode (2001) <i>J Biol Chem</i> <i></i> <i></i> 276: 24 20913-20923<br/>

http://publicationslist.org/y.z.zhang/refid18 2008-11-25T19:21:34Z

Phosphorylation of Tyr(705) and Ser(727) of signal transducer and activator of transcription 3 (STAT3) are known to be required for maximal activation by diverse stimuli. Tyr(705) phosphorylation is generally accepted to be mediated by the Janus kinase family. But the mechanism for STAT3 (Ser(727)) phosphorylation is not well understood. Here, we provide evidence that UVA-induced phosphorylation o...<br/><br/>Y Zhang, G Liu, Z Dong (2001) <i>J Biol Chem</i> <i></i> <i></i> 276: 45 42534-42542<br/>