Yoichiro Homma's Publications List

Only Surgical Resection Can Identify the Second Primary Lung Cancer out of the Metastasis after Gastric Cancer Surgery

2012-11-16T03:37:07Z

Objective: Solitary pulmonary lesions (SPLs) in patients with a history of malignancy require not only the distinction between benign and malignant, but also that between metastatic and primary lesions. We aim to establish the clinical strategy for the treatment of a solitary pulmonary lesion that is detected during the postoperative surveillance for gastric cancer. Methods: We retrospectively ex...

Toru Nakamura, Yoichiro Homma, Naoko Miyata, Shinichiro Ushida, Kazufumi Suzuki, Yoshiro Otsuki, Hidenori Nakamura, Kazuhito Funai and Futoru Toyoda (2012) Japanese Journal of Clinical Oncology :

Inguinal lymph node metastases are recognized with high frequency in rectal adenocarcinoma invading the dentate line. The histological features at the invasive front may predict inguinal lymph node metastasis.

2010-09-23T03:19:34Z

ABSTRACT Background: Inguinal lymph node (ILN) metastasis occurs with high frequency in some of the patients with lower rectal cancer. The aim of this article was to identify risk factors for ILN metastasis in patients with low rectal adenocarcinoma. Method: We retrospectively analyzed 156 patients with lower rectal adenocarcinoma who underwent radical resection (R0) at a single institution. Resul...

T Hamano, Y Homma, Y Otsuki, S Shimizu, H Yobayashi, Y Kobayashi (2010) Colorectal Dis 12:

Severe tumor budding is a risk factor for lateral lymph node metastasis in early rectal cancers.

2010-09-08T04:23:11Z

BACKGROUND: Lateral lymph node (LLN) metastasis sometimes occurs in patients with early rectal cancer that has invaded the submucosa (SM) and muscularis propria (MP). This study aims to identify the risk factor(s) for LLN metastasis in such patients. METHOD: We retrospectively analyzed 65 patients with pathological SM or MP lower rectal adenocarcinoma, for whom radical resection had been performed...

Yoichiro Homma, Takashi Hamano, Yoshiro Otsuki, Shinichi Shimizu, Hiroshi Kobayashi, Yasuyuki Kobayashi (2010) J Surg Oncol 102: 3 230-234

A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.

2009-08-05T10:23:39Z

A common mutation in the gene encoding the cytoplasmic sensor Nod2, involving a frameshift insertion at nucleotide 3020 (3020insC), is strongly associated with Crohn's disease. How 3020insC contributes to this disease is a controversial issue. Clinical studies have identified defective production of interleukin 10 (IL-10) in patients with Crohn's disease who bear the 3020insC mutation, which sugge...

Eiichiro Noguchi, Yoichiro Homma, Xiaoyan Kang, Mihai G Netea, Xiaojing Ma (2009) Nat Immunol 10: 5 471-479

Positive Peritoneal Washing Cytology in Multiple Cavities Can Predict Poor Prognosis of Advanced Gastric Cancer Patients.

2009-10-25T01:38:25Z

BACKGROUND: Positive peritoneal washing cytology (PWC) has been reported to be a poor prognostic factor for gastric cancer. Japanese gastric cancer classifications recommend PWC in Douglas' pouch for advanced gastric cancer. However, the sensitivity of PWC is relatively low. The goal of this study was to investigate whether PWC in multiple cavities increases its sensitivity to predict prognosis. M...

Homma, Ushida, Yamada, Kobayashi, Suzuki (2009) Ann Surg Oncol :

Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.

2009-08-05T10:23:39Z

Production of interleukin (IL)-10, a major immunoregulatory cytokine, by phagocytes during clearance of apoptotic cells is critical to ensuring cellular homeostasis and suppression of autoimmunity. Little is known about the regulatory mechanisms in this fundamental process. We report that IL-10 production stimulated by apoptotic cells was regulated at the point of transcription in a manner depende...

Elaine Y Chung, Jianguo Liu, Yoichiro Homma, Yunhua Zhang, Andrea Brendolan, Matilde Saggese, Jihong Han, Roy Silverstein, Licia Selleri, Xiaojing Ma (2007) Immunity 27: 6 952-964

The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation.

2009-08-05T10:23:39Z

The inflammatory response of macrophages to infectious agents is a highly dynamic and orchestrated process involving the release of a variety of inflammatory mediators, including interleukin-12 (IL-12), as a consequence of the recognition of the pathogens. Regulation of IL-12 gene expression by the anti-inflammatory cytokine IL-10 represents a major homeostatic process underlying host-pathogen and...

Yoichiro Homma, Shanjin Cao, Xiaoyan Shi, Xiaojing Ma (2007) J Interferon Cytokine Res 27: 9 799-808

Interleukin-12: An Update on its Immunological Activities, Signaling and Regulation of Gene Expression

2009-08-05T10:26:08Z

Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against intracellular microbial infection and control of malignancy via its ability to stimulate both innate and adaptive immune effector cells. The potency of IL-12 renders itself to stringent regulation of the timing, locali...

Liu, Jianguo; Cao, Shanjin; Kim, Sunjung; Chung, Elaine Y.; Homma, Yoichiro; Guan, Xiuqin; Jimenez, Violeta; Ma, Xiaojing (2005) Current Immunology Reviews 1: 2 119-137(19)