e.j.breukink - Publications List

Journal articles

R Kusters, E Breukink, A Gallusser, A Kuhn, B Dekruijff A Dual Role for Phosphatidylglycerol in Protein Translocation across the Escherichia-Coli Inner Membrane Journal of Biological Chemistry 269: 2. 1560-1563

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R Kusters, T Devrije, E Breukink, B Dekruijff Secb Protein Stabilizes a Translocation-Competent State of Purified Prephoe Protein Journal of Biological Chemistry 264: 35. 20827-20830

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E van der Bink - van der Laan, J W P Boots, R E J Spelbrink, G M Kool, E Breukink, J A Killian, B de Kruijff Membrane interaction of the glycosyltransferase MurG : a special role for cardiolipin Journal of Bacteriology 185: 13. 3773-3779

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L Lins, P Ducarme, E Breukink, R Brasseur Computational study of nisin interaction with model membrane Biochimica Et Biophysica Acta-Biomembranes 1420: 1-2. 111-120

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N E Kramer, E J Smid, J Kok, B de Kruijff, O P Kuipers, E Breukink Resistance of Gram-positive bacteria to nisin is not determined by Lipid II levels Fems Microbiology Letters 239: 1. 157-161

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S T D Hsu, E Breukink, E Tischenko, M A G Lutters, B de Kruijff, R Kaptein, Amjj Bonvin, N A J van Nuland The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics Nature Structural & Molecular Biology 11: 10. 963-967

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H E Hasper, B de Kruijff, E Breukink Assembly and stability of nisin-Lipid II pores Biochemistry 43: 36. 11567-11575

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S T Hsu, E Breukink, B de Kruijff, R Kaptein, Amjj Bonvin, N A J van Nuland Mapping the targeted membrane pore formation mechanism by solution NMR : The nisin Z and lipid II interaction in SDS micelles Biochemistry 41: 24. 7670-7676

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S T D Hsu, E Breukink, G Bierbaum, H G Sahl, B de Kruijff, R Kaptein, N A J van Nuland, Amjj Bonvin NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles - Conformational changes are a key to antimicrobial activity Journal of Biological Chemistry 278: 15. 13110-13117

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V van Dam, R Sijbrandi, M Kol, E Swiezewska, B de Kruijff, E Breukink Transmembrane transport of peptidoglycan precursors across model and bacterial membranes Molecular Microbiology 64: 4. 1105-1114

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H E van Heusden, B de Kruijff, E Breukink Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin Biochemistry 41: 40. 12171-12178

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C VanKraaij, E Breukink, H S Rollema, R J Siezen, R A Demel, B DeKruijff, O P Kuipers Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity European Journal of Biochemistry 247: 1. 114-120

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A L J vanRaalte, R A Demel, G Verberkmoes, E Breukink, R C A Keller, B deKruijff Influence of the signal sequence and chaperone SecB on the interaction between precursor protein prePhoE and phospholipids (vol 235, pg 207, 1996) European Journal of Biochemistry 237: 3. 882-882

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A L J vanRaalte, R A Demel, G Verberkmoes, E Breukink, R C A Keller, B deKruijff Influence of the signal sequence and chaperone SecB on the interaction between precursor protein prePhoE and phospholipids European Journal of Biochemistry 235: 1-2. 207-214

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I Wiedemann, E Breukink, C van Kraaij, O P Kuipers, G Bierbaum, B de Kruijff, H A Sahl Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity Journal of Biological Chemistry 276: 3. 1772-1779

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J Vanderwolk, M Klose, E Breukink, R A Demel, B Dekruijff, R Freudl, A J M Driessen Characterization of a Bacillus-Subtilis Seca Mutant Protein-Deficient in Translocation Atpase and Release from the Membrane Molecular Microbiology 8: 1. 31-42

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C van Kraaij, E Breukink, H S Rollema, R S Bongers, H A Kosters, B de Kruijff, O P Kuipers Engineering a disulfide bond and free thiols in the lantibiotic nisin Z European Journal of Biochemistry 267: 3. 901-909

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H E van Heusden, B de Kruijff, E Breukink Orientation of the pore-forming antibiotic peptide nisin in presence of its membrane-anchored target lipid II Biophysical Journal 82: 1. 554A-554A

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E J M van Kan, R A Demel, E Breukink, A van der Bent, B de Kruijff Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms Biochemistry 41: 24. 7529-7539

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C van Kraaij, E Breukink, M A Noordermeer, R A Demel, R J Siezen, O P Kuipers, B de Kruijff Pore formation by nisin involves translocation of its C-terminal part across the membrane Biochemistry 37: 46. 16033-16040

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M Hasegawa, A Kawasaki, K Yang, Y Fujimoto, J Masumoto, E Breukink, G Nunez, K Fukase, N Inohara A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses Journal of Biological Chemistry 282: 16. 11757-11764

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R A G Harmsen, N Ghalit, J Kemmink, H W Hilbers, E Breukink, D T S Rijkers, R M J Liskamp Alkene/Alkane-bridged mimics of the lantibiotic Nisin : Toward novel peptide-based antibiotics Biopolymers 88: 4. 583-583

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E Breukink, B de Kruijff Lipid II as a target for antibiotics Nature Reviews Drug Discovery 5: 4. 321-332

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E Breukink, R A Demel, G Dekortekool, B Dekruijff Seca Insertion into Phospholipids Is Stimulated by Negatively Charged Lipids and Inhibited by Atp - a Monolayer Study Biochemistry 31: 4. 1119-1124

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E Breukink, P Ganz, B de Kruijff, J Seelig Binding of nisin Z to bilayer vesicles as determined with isothermal titration calorimetry Biochemistry 39: 33. 10247-10254

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E Breukink, R C A Keller, B Dekruijff Nucleotide and Negatively Charged Lipid-Dependent Vesicle Aggregation Caused by Seca - Evidence That Seca Contains 2 Lipid-Binding Sites Febs Letters 331: 1-2. 19-24

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E Breukink, B de Kruijff The lantibiotic nisin, a special case or not? Biochimica Et Biophysica Acta-Biomembranes 1462: 1-2. 223-234

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E Breukink, B B Bonev, I Wiedemann, H G Sahl, A Watts, B de Kruijff Specific interaction of the lantibiotic nisin with lipid II leads to highly efficient pore formation Biophysical Journal 80: 1. 2A-2A

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B B Bonev, E Breukink, E Swiezewska, B De Kruijff, A Watts Targeting extracellular pyrophosphates underpins the high selectivity of nisin Faseb Journal 18: 15. 1862-1869

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P Born, E Breukink, W Vollmer In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli Journal of Biological Chemistry 281: 37. 26985-26993

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E Breukink A lesson in efficient killing from two-component lantibiotics Molecular Microbiology 61: 2. 271-273

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E Breukink, R Kunsters, B Dekruijff Invitro Studies on the Folding Characteristics of the Escherichia-Coli Precursor Protein Prephoe (European Journal Biochemistry, Vol 208, Pg 420, 1990) European Journal of Biochemistry 211: 3. 909-909

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E Breukink, R Kusters, B Dekruijff Invitro Studies on the Folding Characteristics of the Escherichia-Coli Precursor Protein Prephoe - Evidence That Secb Prevents the Precursor from Aggregating by Forming a Functional Complex European Journal of Biochemistry 208: 2. 419-425

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W G M Breukink-Engbers Monitoring therapy with anticoagulants in The Netherlands Seminars in Thrombosis and Hemostasis 25: 1. 37-42

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T denBlaauwen, J G deWit, H Gosker, C vanderDoes, E J Breukink, L deLeij, A J M Driessen Inhibition of preprotein translocation and reversion of the membrane inserted state of SecA by a carboxyl terminus binding MAb Biochemistry 36: 30. 9159-9168

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D N Ganchev, H E Hasper, E Breukink, B de Kruijff Size and orientation of the lipid II headgroup as revealed by AFM imaging Biochemistry 45: 19. 6195-6202

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E Breukink, C vanKraaij, A vanDalen, R J Siezen, R A Demel, O P Kuipers, B deKruijff Acidic lipid dependent binding, insertion and aggregation of the lantibiotic nisin are involved in pore formation Biophysical Journal 72: 2. TU323-TU323

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E Breukink, C vanKraaij, R A Demel, R J Siezen, O P Kuipers, B deKruijff The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane Biochemistry 36: 23. 6968-6976

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E Breukink, N Nouwen, A Vanraalte, S Mizushima, J Tommassen, B Dekruijff The C-Terminus of Seca Is Involved in Both Lipid-Binding and Secb Binding Journal of Biological Chemistry 270: 14. 7902-7907

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E Breukink, H E van Heusden, P J Vollmerhaus, E Swiezewska, L Brunner, S Walker, A J R Heck, B de Kruijff Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes Journal of Biological Chemistry 278: 22. 19898-19903

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E Breukink, C van Kraaij, A van Dalen, R A Demel, R J Siezen, B de Kruijff, O P Kuipers The orientation of nisin in membranes Biochemistry 37: 22. 8153-8162

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U Bertsche, E Breukink, T Kast, W Vollmer In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli Journal of Biological Chemistry 280: 45. 38096-38101

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