Laboratory of Molecular Haematopoiesis and Stem Cell Biology
Dept. of Experimental and Clinical Medicine
University of Catanzaro Magna Graecia
Biosciences Building, Level 7
University Campus 'Salvatore Venuta'
Viale Europa, Loc. Germaneto
88100 Catanzaro - Italy
Tel.: +39 (0961) 369-4072
Fax: +39 (0961) 369-4073
 | morrone@unicz.it |
Education and training
1983 MD, University of Naples, Naples, Italy - Certificate of the Board of Physicians.
1983-1984 Postdoctoral fellow, Institute of Biochemistry, II Medical School, University of Naples; part-time attending physician, Laboratory of clinical biochemistry, II Medical School, University of Naples.
1984 Visiting fellow, Laboratory of experimental haematology, Dept. of Haematology - Oncology, Albert-Ludwigs University, Freiburg, FRG.
1985-1989 Visiting fellow, Gene structure and regulation programme, European Molecular Biology Laboratory, Heidelberg, FRG.
Positions held and academic responsibilities
1988-1992 Lecturer of Biochemistry, University of Reggio Calabria Medical School, Catanzaro, Italy.
1993-1995 Member of the Steering Committee of the Faculty of Pharmacy, Catanzaro, Italy.
1992-2000 Associate Professor of Biochemistry, University “Magna Graecia”, Catanzaro, Italy.
1995-2000 Project Leader, CEINGE Genetic Engineering Center, Naples, Italy.
since 2000 Professor of Biochemistry, University “Magna Graecia”, Catanzaro, Italy.
2000-2003 Visiting Professor, Laboratory of developmental hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
1999-2007 Chairman of the PhD programme in Experimental immunology, University “Magna Graecia”, Catanzaro, Italy.
2004-2007 Dean of Research, University “Magna Graecia”, Catanzaro, Italy.
2005-2008 Member of the external advisory Board, Dept. of Internal Medicine I: Hematology/Oncology, Albert-Ludwigs University, Freiburg i.Br. (Germany)
2010-2011 Member of the advisory Board of the Research Consortium "Tumor Stem Cells" of the Deutche Krebshilfe.
since 2007 Chairman, PhD Programme in Molecular oncology, University of Catanzaro "Magna Græcia".
since 2013 President of the School of bio-medical PhD Programmes "Life sciences and technologies", University of Catanzaro "Magna Græcia".
Scientific interests
1978-81 Analysis of the surface-membrane transport and intracellular accumulation of radioisotopes used as tumour scanning agents in normal and transformed chick embryo fibroblasts and mammalian cell lines (MD thesis).
1982-85 Study of the regulation of growth in normal and leukaemic haematopoietic cells. Characterisation of cytokine production in human leukocyte subpopulations and identification of autocrine mechanisms supporting the proliferation of leukaemic cells.
1985-89 Characterisation of the role and of the mechanism of action of interleukin-6 and transforming growth factor β in the regulation of genes encoding human acute phase proteins. Identification of cis-acting elements and DNA-binding factors that control the acute phase gene expression.
since 1990 Dissection of molecular pathways that control survival/apoptosis, self-renewal, proliferation and gene expression in normal and malignant human haematopoietic stem cells. Design of novel therapeutic approaches for haematopoietic malignancies. Identification, cloning and characterisation of genes differentially expressed in the immature compartment of the haematopoietic system. Production of vectors for efficient gene transfer in haematopoietic stem cells. Functional characterisation of candidate oncogenes and regulatory molecules by enforced expression in haematopoietic stem and progenitor cells and analysis of the resulting phenotypes in vitro and in vivo.
Scientific Societies
- International Society for Experimental Hematology
- International Society for Stem Cell Research
- Associazione di Biologia Cellulare e del Differenziamento
1983 MD, University of Naples, Naples, Italy - Certificate of the Board of Physicians.
1983-1984 Postdoctoral fellow, Institute of Biochemistry, II Medical School, University of Naples; part-time attending physician, Laboratory of clinical biochemistry, II Medical School, University of Naples.
1984 Visiting fellow, Laboratory of experimental haematology, Dept. of Haematology - Oncology, Albert-Ludwigs University, Freiburg, FRG.
1985-1989 Visiting fellow, Gene structure and regulation programme, European Molecular Biology Laboratory, Heidelberg, FRG.
Positions held and academic responsibilities
1988-1992 Lecturer of Biochemistry, University of Reggio Calabria Medical School, Catanzaro, Italy.
1993-1995 Member of the Steering Committee of the Faculty of Pharmacy, Catanzaro, Italy.
1992-2000 Associate Professor of Biochemistry, University “Magna Graecia”, Catanzaro, Italy.
1995-2000 Project Leader, CEINGE Genetic Engineering Center, Naples, Italy.
since 2000 Professor of Biochemistry, University “Magna Graecia”, Catanzaro, Italy.
2000-2003 Visiting Professor, Laboratory of developmental hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
1999-2007 Chairman of the PhD programme in Experimental immunology, University “Magna Graecia”, Catanzaro, Italy.
2004-2007 Dean of Research, University “Magna Graecia”, Catanzaro, Italy.
2005-2008 Member of the external advisory Board, Dept. of Internal Medicine I: Hematology/Oncology, Albert-Ludwigs University, Freiburg i.Br. (Germany)
2010-2011 Member of the advisory Board of the Research Consortium "Tumor Stem Cells" of the Deutche Krebshilfe.
since 2007 Chairman, PhD Programme in Molecular oncology, University of Catanzaro "Magna Græcia".
since 2013 President of the School of bio-medical PhD Programmes "Life sciences and technologies", University of Catanzaro "Magna Græcia".
Scientific interests
1978-81 Analysis of the surface-membrane transport and intracellular accumulation of radioisotopes used as tumour scanning agents in normal and transformed chick embryo fibroblasts and mammalian cell lines (MD thesis).
1982-85 Study of the regulation of growth in normal and leukaemic haematopoietic cells. Characterisation of cytokine production in human leukocyte subpopulations and identification of autocrine mechanisms supporting the proliferation of leukaemic cells.
1985-89 Characterisation of the role and of the mechanism of action of interleukin-6 and transforming growth factor β in the regulation of genes encoding human acute phase proteins. Identification of cis-acting elements and DNA-binding factors that control the acute phase gene expression.
since 1990 Dissection of molecular pathways that control survival/apoptosis, self-renewal, proliferation and gene expression in normal and malignant human haematopoietic stem cells. Design of novel therapeutic approaches for haematopoietic malignancies. Identification, cloning and characterisation of genes differentially expressed in the immature compartment of the haematopoietic system. Production of vectors for efficient gene transfer in haematopoietic stem cells. Functional characterisation of candidate oncogenes and regulatory molecules by enforced expression in haematopoietic stem and progenitor cells and analysis of the resulting phenotypes in vitro and in vivo.
Scientific Societies
- International Society for Experimental Hematology
- International Society for Stem Cell Research
- Associazione di Biologia Cellulare e del Differenziamento
