LITIS EA 4108 (Computer Science, Information Processing, and Systems Laboratory)
Normandie Université- University of Rouen
76821 Mont Saint Aignan Cedex
France
 | helene.dauchel@univ-rouen.fr |
Since september 1994 I am an assistant professor in the department of biology at the University of Rouen.
Present research projects and responsibilities
Coordinator of applied bioinformatics developments for NGS data analysis, from raw data to annotation and biological interpretation; human Exome-Seq, plant mRNA-Seq for biomedical innovation and personalized medicine
Research projects:
My research activity has evolved in four different periods since 1989. Gradually, through biological topics going from immunopathology in human (Ph. D.), from the vegetal cell wall growth in the flax model with wet experimental approaches (first position in 1994 in plant molecular biology), in 2000 I moved for a second position in genomics and applied bioinformatics and started working in comparative genomics area.
Since 2010, Next Generation Sequencing and data analysis are central of my activities. Collaborative research programs in my computer team (LITIS-TIBS) with biomedical labs (IRIB-HN), focuse on the development of pipelines and innovating user-friendly analytic tools for NGS data analysis, annotation and interpretation (human Exome-Seq and plant mRNA-Seq). As a biologist and applied bioinformatician researcher, I organize the interface between many labs staff in multiple sites (University, Hospital, Cancer Center), comprising theorical bioinformaticians and biostatisticians, bioinformatician engineers and clinical or plant wet biologists. In close collaboration with the actors I impulse innovative analysis strategies, from raw data to biological interpretations. I manage the tool developments to support biomedical labs efforts (cancer, genetics, neuropsychiatric, algae), towards translational genomics and predictive, preventive and personalized clinical care
Teaching:
- Since September 1994, I am assistant professor in the department of biology at the University of Rouen Normandy. Starting with new courses in plant biotechnology and immunology, my current courses are in molecular genetics, genomics and bioinformatics analysis for BSc and MSc program.
- Since 1999, I am the director of the Bioinformatics MSc of University of Rouen, http://masterbioinfo.univ-rouen.fr/, hence contributing to the education effort of engineers and researchers in genomics and bioinformatics for prominent institutions in France, in Europe and Canada. Pioneer in France, this master is an original three years apprenticeship course and benefits of a prestigious network of partner structures (Ex : CNRS, INSERM, INRA, Genoscope, CEA, ENS, Curie Institut, Pasteur Institut, private biotechnology companies).
* High-throughput technologies for genomics and transcriptomics: NGS technologies and applications (DNA-seq, RNA-seq), array technologies.
* Genome variability : evolution and biomedical context
* Bioinformatics analysis: international resources in bioinformatics (main databases, genome browsers), structural and functional annotation of genomes and proteomes, sequence comparison and multiple alignment, genome evolution and comparative genomics
Present research projects and responsibilities
Coordinator of applied bioinformatics developments for NGS data analysis, from raw data to annotation and biological interpretation; human Exome-Seq, plant mRNA-Seq for biomedical innovation and personalized medicine
Research projects:
My research activity has evolved in four different periods since 1989. Gradually, through biological topics going from immunopathology in human (Ph. D.), from the vegetal cell wall growth in the flax model with wet experimental approaches (first position in 1994 in plant molecular biology), in 2000 I moved for a second position in genomics and applied bioinformatics and started working in comparative genomics area.
Since 2010, Next Generation Sequencing and data analysis are central of my activities. Collaborative research programs in my computer team (LITIS-TIBS) with biomedical labs (IRIB-HN), focuse on the development of pipelines and innovating user-friendly analytic tools for NGS data analysis, annotation and interpretation (human Exome-Seq and plant mRNA-Seq). As a biologist and applied bioinformatician researcher, I organize the interface between many labs staff in multiple sites (University, Hospital, Cancer Center), comprising theorical bioinformaticians and biostatisticians, bioinformatician engineers and clinical or plant wet biologists. In close collaboration with the actors I impulse innovative analysis strategies, from raw data to biological interpretations. I manage the tool developments to support biomedical labs efforts (cancer, genetics, neuropsychiatric, algae), towards translational genomics and predictive, preventive and personalized clinical care
Teaching:
- Since September 1994, I am assistant professor in the department of biology at the University of Rouen Normandy. Starting with new courses in plant biotechnology and immunology, my current courses are in molecular genetics, genomics and bioinformatics analysis for BSc and MSc program.
- Since 1999, I am the director of the Bioinformatics MSc of University of Rouen, http://masterbioinfo.univ-rouen.fr/, hence contributing to the education effort of engineers and researchers in genomics and bioinformatics for prominent institutions in France, in Europe and Canada. Pioneer in France, this master is an original three years apprenticeship course and benefits of a prestigious network of partner structures (Ex : CNRS, INSERM, INRA, Genoscope, CEA, ENS, Curie Institut, Pasteur Institut, private biotechnology companies).
* High-throughput technologies for genomics and transcriptomics: NGS technologies and applications (DNA-seq, RNA-seq), array technologies.
* Genome variability : evolution and biomedical context
* Bioinformatics analysis: international resources in bioinformatics (main databases, genome browsers), structural and functional annotation of genomes and proteomes, sequence comparison and multiple alignment, genome evolution and comparative genomics
