Abstract: PURPOSE: To determine whether physicians providing primary care in Ontario were aware of guidelines published by Health Canada's National Advisory Committee on Immunization (NACI), their opinions about the varicella vaccine, and factors that influence use of the vaccine. METHODS: A questionnaire examining awareness, knowledge, and perceived barriers to using varicella vaccine was developed and mailed to a random sample of 500 family physicians and 400 pediatricians practising in Ontario. RESULTS: To the 900 questionnaires mailed, 284 family physicians (56.9%) and 232 pediatricians (59.2%) responded. Fifty-six percent of family physicians and 95.4% of pediatricians providing primary care were aware of the Health Canada guidelines. Physicians who were aware of the Health Canada guidelines were more knowledgeable about the vaccine and were more likely to recommend it. Both groups of physicians identified cost (not covered by the government), problems with storage and handling, and concerns about long-term immunity as barriers to use of the vaccine. CONCLUSION: While awareness of the guidelines was associated with better knowledge of and following recommendations for the vaccine, Health Canada guidelines were not widely distributed to all primary care providers. One way to encourage incorporation of varicella vaccine guidelines into practice would be to improve dissemination of the guidelines to all primary care providers.

Abstract:

Abstract: OBJECTIVES: To examine the association between Helicobacter pylori infection and non-ulcer dyspepsia, and to assess the effect of eradicating H pylori on dyspeptic symptoms in patients with non-ulcer dyspepsia. DESIGN: Systematic review and meta-analysis of (a) observational studies examining the association between Helicobacter pylori infection and non-ulcer dyspepsia (association studies), and (b) therapeutic trials examining the association between eradication of H pylori and dyspeptic symptoms in patients with non-ulcer dyspepsia (eradication trials). DATA SOURCES: Randomised controlled trials and observational studies conducted worldwide and published between January 1983 and March 1999. MAIN OUTCOME MEASURES: Summary odds ratios and summary symptom scores. RESULTS: 23 association studies and 5 eradication trials met the inclusion criteria. In the association studies the summary odds ratio for H pylori infection in patients with non-ulcer dyspepsia was 1.6 (95% confidence interval 1.4 to 1.8). In the eradication trials the summary odds ratio for improvement in dyspeptic symptoms in patients with non-ulcer dyspepsia in whom H pylori was eradicated was 1.9 (1.3 to 2.6). CONCLUSIONS: Some evidence shows an association between H pylori infection and dyspeptic symptoms in patients referred to gastroenterologists. An improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom H pylori was eradicated.