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Markus Melloh

Western Australian Institute for Medical Research (WAIMR)
University of Western Australia
B Block
Hospital Avenue
QEII Medical Centre
Nedlands WA 6009
Australia
markus.melloh@uwa.edu.au
Markus is an Orthopaedic Surgeon and Rheumatologist trained at the Humboldt University and the Free University Berlin, Germany. In 2003, he completed his Medical Research Doctorate (DMedSc) in Sports Medicine at the Charité/ Humboldt University Berlin on the variability of physiological values during constant prolonged workloads.

After his Doctorate Markus was appointed Head of an Interdisciplinary Pain Clinic before taking up a position as Post-doctoral Research Fellow of EuroSpine, the Spine Society of Europe and being appointed International Coordinator of the Spine Tango Spine Registry at the MEM Research Center, University of Berne, Switzerland. In 2007, he accomplished a Master's Degree in Public Health at the Swiss School of Public Health, University of Zurich, Switzerland focusing on prognostic factors of low back pain. From 2007-2011, Markus held appointments as Senior Clinical Lecturer at the Department of Orthopaedic Surgery and as Programme Director of Spine Research at the Centre for Musculoskeletal Outcomes Research (CMOR), Dunedin School of Medicine, University of Otago, New Zealand where he also completed a PhD in Orthopaedic Surgery. In 2011, he accomplished a Diploma in Business Administration at the Edinburgh Business School, UK where he continues his studies towards a Specialist MBA in Strategic Planning.

Currently, Markus is appointed as Research Associate Professor at the Western Australian Institute for Medical Research (WAIMR), University of Western Australia. He also acts as Director of Research for Getparticipants, an international internet-based portal that connects participants and researchers. Markus is elected active member of the exclusive International Society for the Study of the Lumbar Spine (ISSLS), the premier international society for spine research; ISSLS membership is only by invitation requiring a significant contribution of the applicant to spine research. Furthermore, he is elected member of the Spine Society of Australia (SSA), Spine Society of Europe (EuroSpine) and North American Spine Society (NASS). Markus has a track record of almost 40 peer-reviewed publications and 70 research abstracts in the last 5 years, and more than 110 oral and 80 poster presentations at national/international conferences - including almost 50 invited presentations.

Journal articles

in press
accepted for publication
2012
2011
2010
2009
2008
M Melloh, C Roder, A Elfering, J C Theis, U Muller, L P Staub, E Aghayev, T Zweig, T Barz, T Kohlmann, S Wieser, P Juni, M Zwahlen (2008)  Differences across health care systems in outcome and cost-utility of surgical and conservative treatment of chronic low back pain : a study protocol   BMC Musculoskelet Disord. 9: 81.  
Abstract: BACKGROUND: There is little evidence on differences across health care systems in choice and outcome of the treatment of chronic low back pain (CLBP) with spinal surgery and conservative treatment as the main options. At least six randomised controlled trials comparing these two options have been performed; they show conflicting results without clear-cut evidence for superior effectiveness of any of the evaluated interventions and could not address whether treatment effect varied across patient subgroups. Cost-utility analyses display inconsistent results when comparing surgical and conservative treatment of CLBP. Due to its higher feasibility, we chose to conduct a prospective observational cohort study. METHODS: This study aims to examine if1. Differences across health care systems result in different treatment outcomes of surgical and conservative treatment of CLBP2. Patient characteristics (work-related, psychological factors, etc.) and co-interventions (physiotherapy, cognitive behavioural therapy, return-to-work programs, etc.) modify the outcome of treatment for CLBP3. Cost-utility in terms of quality-adjusted life years differs between surgical and conservative treatment of CLBP.This study will recruit 1000 patients from orthopaedic spine units, rehabilitation centres, and pain clinics in Switzerland and New Zealand. Effectiveness will be measured by the Oswestry Disability Index (ODI) at baseline and after six months. The change in ODI will be the primary endpoint of this study.Multiple linear regression models will be used, with the change in ODI from baseline to six months as the dependent variable and the type of health care system, type of treatment, patient characteristics, and co-interventions as independent variables. Interactions will be incorporated between type of treatment and different co-interventions and patient characteristics. Cost-utility will be measured with an index based on EQol-5D in combination with cost data. CONCLUSION: This study will provide evidence if differences across health care systems in the outcome of treatment of CLBP exist. It will classify patients with CLBP into different clinical subgroups and help to identify specific target groups who might benefit from specific surgical or conservative interventions. Furthermore, cost-utility differences will be identified for different groups of patients with CLBP. Main results of this study should be replicated in future studies on CLBP.
Notes: Melloh, Markus xD;Roder, Christoph xD;Elfering, Achim xD;Theis, Jean-Claude xD;Muller, Urs xD;Staub, Lukas P xD;Aghayev, Emin xD;Zweig, Thomas xD;Barz, Thomas xD;Kohlmann, Thomas xD;Wieser, Simon xD;Juni, Peter xD;Zwahlen, Marcel xD;England xD;BMC musculoskeletal disorders xD;BMC Musculoskelet Disord. 2008 Jun 6;9:81.
C Roder, S Eggli, P Munger, M Melloh, A Busato (2008)  Patient characteristics differently affect early cup and stem loosening in THA : a case-control study on 7,535 patients   Int Orthop. 32: (1). 33-8.  
Abstract: We postulated that certain patient characteristics have different effects on early THA component loosening. With two matched case-control studies we assessed 3,028 cups and 5,224 stems. Loosening was defined using signs of mechanical component failure on routine follow-up radiographs or revision for aseptic loosening. Women and men had similar cup-loosening odds, but women had lower odds for stem loosening (p < 0.0001). Odds for cup loosening decreased by 2.1% per additional year of age (p = 0.0004), those for stem loosening by 2.4% (p < 0.0001). Each additional kilogram of weight decreased cup loosening odds by 1.3% (p = 0.0051). Each additional unit of BMI increased stem loosening odds (p = 0.0109). Charnley classes B and C were protective factors against loosening of both components. There were no risk differences for the various main diagnoses. Certain patient characteristics differently affected early cup and stem loosening, although some characteristics had the same protective or harmful effect on component survival.
Notes: Roder, C xD;Eggli, S xD;Munger, P xD;Melloh, M xD;Busato, A xD;Germany xD;International orthopaedics xD;Int Orthop. 2008 Feb;32(1):33-8. Epub 2007 Feb 15.
T Barz, M Melloh, L Staub, C Roeder, J Lange, F G Smiszek, J C Theis, H R Merk (2008)  The diagnostic value of a treadmill test in predicting lumbar spinal stenosis   Eur Spine J. 17: (5). 686-690.  
Abstract: Lumbar spinal stenosis is a frequent indication for spinal surgery. The predictive quality of treadmill testing and MRI for diagnostic verification is not yet clearly defined. Aim of the current study was to assess correlations between treadmill testing and MRI findings in the lumbar spine. Twenty-five patients with lumbar spinal stenosis were prospectively examined. Treadmill tests were performed and the area of the dural sac and neuroforamina was examined with MRI for the narrowest spinal segment. VAS and ODI were used for clinical assessment. The median age of the patients was 67 years. In the narrowest spinal segment the median area of the dural sac was 91 mm(2). The median ODI was 66 per cent. The median walking distance in the treadmill test was 70 m. The distance reached in the treadmill test correlated with the area of the dural sac (Spearman's rho = 0.53) and ODI (rho = -0.51), but not with the area of the neuroforamina and VAS. The distance reached in the treadmill test predicts the grade of stenosis in MRI but has a limited diagnostic importance for the level of clinical symptoms in lumbar spinal stenosis.
Notes: Journal article xD;European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society xD;Eur Spine J. 2008 Feb 8;.
2007
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