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Nacim Betrouni
Inserm U703
Institut de Technologie Médicale
Pavillon Vancostenobel
CHRU Lille
Lille Cedex - France
tel: 33(0)320446722
fax: 33(0)320446715
n-betrouni@chru-lille.fr
Betrouni Nacim, né le 12 octobre 1976.
Titres Universitaires
Diplôme d’Ingénieur de l’Université Mouloud Mammeri de Tizi Ouzou, Algérie, 1999.
D.E.A. Automatique et Informatique Industrielle, Université des Sciences et Techniques de Lille, 2001.
Doctorat de l'Université en Automatique et Informatique Industrielle, Université des Sciences et Techniques (Lille 1), 2004.
Fonctions Universitaires et Hospitalo-Universitaires
Assistant hospitalo-universitaire au Laboratoire de Biophysique, Faculté de Médecine, Université Lille 2, depuis novembre 2004.
Membre du groupe Quantification en imagerie fonctionnelle du GdR Stic-Santé (CNRS-INSERM)
Membre du projet CMCU avec une collaboration avec le Laboratoire de Biophysique de la Faculté de Médecine de Monastir, Tunisie.
Membre du Cancéropôle Nord-ouest (Axe 9 : Imagerie et Radiothérapie)
Membre de la Société Française de Génie Biologique et Médicale (SFGBM)

Journal articles

2007
R Lopes, P Dubois, A S Dewalle, M Steinling, S Maouche, N Betrouni (2007)  3D Mutifractal Analysis of Cerebral Tomoscintigraphy Images   International Journal of Computer Assisted Radiology and Surgery 2: S17-S18  
Abstract: In this study, we describe the preliminary results of a tool to assist the diagnosis for the characterization of pathological cases of epilepsy disease using cerebral tomoscintigraphy images. The tool is based on the use of multifractal modelling to detect the local changes of homogeneity.
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N Betrouni, M Vermandel, D Pasquier, J Rousseau (2007)  Ultrasound Image Guided Patient Setup for Prostate Cancer Conformal Radiotherapy   Pattern Recognition Letters 28: 13. 1808-1817  
Abstract: The radiotherapy planning procedure is achieved using images obtained from computed tomography (CT) or magnetic resonance imaging (MR). These images are taken before the treatment which is performed in several sessions over several weeks. At the beginning of each session, the patient has to be positioned on the treatment couch under the linear accelerator in the same position as during MR or CT imaging and planning, and the organs are assumed to be in the same place. Currently, the methods used for this repositioning are based on the external anatomy of the patient and assume that the internal structures do not move. In this study, we present a new approach, suited to clinical practice, for the automatic repositioning of patients in prostate cancer radiotherapy. It is based on localisation by ultrasound images and optical stereolocalisation and on a matching with some images regenerated in the planning volume. The method exploits a statistical model of the prostate to automatically extract its contours. The first tests in conditions of a radiotherapy session show that the method is able to obtain a patient setup with an accuracy of about 1.4 mm.
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N Betrouni, R Viard, P Dubois, R Lopes, A S Dewalle, M Vermandel (2007)  New simple procedure for spatial calibration of freehand ultrasound machine   International Journal of Computer Assisted Radiology and Surgery 2: S31-S33  
Abstract: The purpose of our study is to propose a practical and easy to use method for the calibration of a freehand ultrasound machine. We introduce a new spatial calibration of the probe based on a simple phantom. The method includes automatic features extraction by the Hough transform algorithm and a robust parameters optimization. Experiments demonstrate the reproducibility of the method. Many evaluation were conducted to evaluate the accuracy of the 3D measures realized from the image, we found errors less than 1.4 mm. The technique we describe is pragmatic way for a rapid and accurate calibration of a freehand ultrasound system. Technique that could be used for the intra-operative visualization procedures
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David Pasquier, Thomas Lacornerie, Maximilien Vermandel, Jean Rousseau, M D Eric Lartigau, Nacim Betrouni (2007)  Automatic segmentation of pelvic structures from MRI images for prostate cancer radiotherapy   International Journal of Oncology Biology Physics 68: 2. 592-600  
Abstract: Purpose/Objective. Target volumes and organ at risk delineation is a time consuming task in radiotherapy planning. The development of automated segmentation tools still remains a difficult problem due to pelvic organs shape variability. In this paper 3D deformable model approach and seeded region growing algorithm for prostate and organ at risk automatic delineation on MR images are evaluated. Methods and materials. Manual and automatic delineation were compared in 24 patients using a sagittal T2-w TSE and an axial T1-w 3D FFE or TSE sequences. For prostate automatic delineation, an organ model-based method was used. Prostate without seminal vesicles was delineated as CTV. For bladder and rectum automatic delineation, a seeded region growing method was used. Manual contouring was considered as the reference. The following parameters were measured: volume ratio (Vr) (automatic/manual), volume overlap (Vo) (ratio of the volume of intersection to the volume of union, optimal value=1), correctly delineated volume (Vc) (percent ratio of the volume of intersection to the manual defined volume, optimal value=100). Results. For CTV, the Vr, Vo and Vc were 1.13 (±0.1), 0.78 (±0.05) and 94.75 (±3.3) respectively. For rectum, the Vr, Vo and Vc were 0.97 (±0.1), 0.78 (±0.06) and 86.52 (±5) respectively. Vr, Vo and Vc were 0.95 (±0.03), 0.88 (±0.03) and 91.29 (±3.1) for bladder respectively. Conclusion. Our results show that organ model method is robustness and leads to reproducible prostate segmentation with minor interactive corrections. For bladder and rectum automatic delineation MRI soft tissue contrast allows to use region growing methods.
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2006
Betrouni N Vermandel M Pasquier D Maouche S Rousseau (2006)  Repositionnement du patient en radiothérapie conformationnelle du cancer de la prostate par recalage d'images échographiques et d'images de résonance magnétique.   Traitement du signal 23: 4. 321-332  
Abstract: En radiothérapie conformationnelle, le calcul des doses et des balistiques des faisceaux à appliquer pour irradier la tumeur se fait en se basant sur des images tomographiques (IRM ou scanner (TDM)) réalisées avant le traitement. Celui-ci dure plusieurs séances réparties sur plusieurs semaines. Au début de chaque séance le patient doit être installé sur la table de traitement dans les conditions initiales de planification. Actuellement, les méthodes les plus utilisées pour ce repositionnement se basent sur l’anatomie externe du patient et supposent une immobilité des organes internes. De ce fait, des marges d’erreurs sont prévues dans la définition des volumes pour prendre en considération ces mouvements et les erreurs du repositionnement. Ce travail présente une nouvelle approche, adaptée aux conditions cliniques, pour le repositionnement automatique du patient en radiothérapie de la prostate. Elle est basée sur un repérage temps réel par échographie et une mise en correspondance rapide et précise avec des images générées dans le volume de planification. La méthode exploite une modélisation statistique de la prostate pour extraire automatiquement ses contours. Les premiers tests de la méthode dans les conditions réelles d’une séance de radiothérapie montrent que le repositionnement peut être obtenu avec une précision de l’ordre de 1.4 mm.
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2005
Nacim Betrouni, Maximilien Vermandel, David Pasquier Salah Maouche, Jean Rousseau (2005)  Segmentation of abdominal ultrasound images of the prostate using a priori information and an adapted noise filter   Computerized Medical Imaging and Graphics 29: 1. 43-51  
Abstract: This article discusses a method for the automatic segmentation of trans-abdominal ultrasound images of the prostate. Segmentation begins with the application of a filter to enhance the contours without modifying the image information. It combines adaptive morphological filtering and median filtering to detect the noise-containing regions and smooth them. A heuristic optimization algorithm searches for the contour initialized from a prostate model. The performance of the algorithm was tested by comparing the resulting contours with those obtained by manual segmentation. The average distance between the contours was 2.5 mm and the average coverage index was 93%.
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2004
N Betrouni, J Rousseau, S Maouche (2004)  An hybrid system for 3D location in medical interventions   Wseas transactions on Biology and biomedicine 1: 51-54  
Abstract: This paper describes a localization system composed of a stereovision system with two cameras and an ultrasound system. After calibration of 2 cameras, a mask of infra-red LEDs is mounted on the probe. A method for spatial and temporal calibration is presented and used to calibrate the ultrasound system. Position and orientation of each ultrasonic cross-section are precisely measured and a 3D localization is available from the US images with an accuracy of 0.4 mm. We present two clinical applications of the system which gave good results in each case.
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Conference papers

2006
2005
2004
2003

PhD theses

2004
Nacim Betrouni (2004)  REPOSITIONNEMENT DU PATIENT EN RADIOTHERAPIE CONFORMATIONNELLE DE LA PROSTATE PAR FUSION D’IMAGES   Université des Sciences et Technologie de Lille  
Abstract: En radiothérapie conformationnelle le calcul des doses et les balistiques des rayons à appliquer pour irradier la tumeur se fait en se basant sur des images scanner prises avant le traitement qui dure plusieurs séances réparties en plusieurs semaines. Au début de chaque séance le patient doit être installé sur la table de traitement dans les conditions initiales de planification. Actuellement, les méthodes les plus utilisées pour ce repositionnement souffrent de lacunes car elles se basent sur l’anatomie externe et supposent une immobilité des organes internes. Dans le cadre de cette thèse, nous avons présenté une méthode, adaptée aux conditions cliniques, pour le repositionnement automatique. Elle est basée sur un repérage temps réel par échographie et stéréovision et une mise en correspondance avec les images de planification. La méthode exploite une modélisation statistique de la prostate pour extraire ses contours. In conformal radiotherapy the dosimetry and ballistics of the rays to apply to irradiate the tumour are calculated using images provided by tomographic imaging taken before the treatment, which may lasts several meetings distributed in several weeks. At the beginning of each session, the patient has to be positioned on the treatment couch under the linear accelerator in the same position as during MR or CT imaging and planning, and the organs are assumed to be in the same place. Currently, the methods used for this repositioning suffer from gaps because they are based on the external anatomy and suppose an immobility of the internal bodies. In this study, we have presented a method, adapted to the clinical conditions, for the automatic set up of patient for prostate radiotherapy. It is based on localisation by ultrasonic images and stereovision and a matching with planning images. The method exploits a statistical modelling of the prostate to automatically extract its contours.
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