Professor in Pharmaceutics Having 10 years of Teaching experience and 2 Years of Industrial Experience as a Manufacturing chemist in Parenterals department. active participant of reaesrch projects and Seminars ect.
Abstract: ABSTRACT
In the present study an attempt was made to design the transdermal drug delivery system of Naproxen with Ethylcellulose and Hydroxy propyl methyl cellulose polymer in various concentrations. Tramsdermal films were fabricated by matrix technique with various polymer proportions using dibutylphthalate as plasticizer. These transdermal drug patches were characterized for their thickness, tensile strength, content uniformity, in-vitro release. The release profiles were found to be varied with various concentrations of Ethylcellulose Polymer. The sample of patches prepared with 2:8 and 8:2 ratios of Ethyl cellulose and Hydroxy propyl methyl cellulose shows highest and lowest in-vitro release of Naproxen respectively.
Notes: naproxen that releases from the transdermal patches of NF-III (EC-HPMC 6:4) and NF-IV (EC-HPMC 8:2) showed prolonged drug release. The high proportion of hydrophobic polymer ethyl cellulose is responsible for sustaining the drug release. This research work highlights the best combination of drug and polymer concentrations and also provides a rational guideline for formulating controlled release transdermal patches. The formulated transdermal delivery system of Naproxen can be a best alternate to the oral formulations for effectiv therapy of inflammatory conditions.
Abstract: ABSTRACT
Title: Evaluation of Anti-inflammatory activity of methanolic extract of Spermacoce hispida Linn.Aim: To confirm the anti-inflammatory activity of Spermacoce
hispida Linn which is traditionally utilized in India.Method: The Methanolic extract of Spermacoce hispida Linn whole plant at the dose level of 100 and 200
mg/kg body weight were evaluated for anti-inflammatory activity in wistar albino male rats by using carrageenan induced paw edema. Results and
conclusion: The extract exhibited significant anti-inflammatory activity, which supports the traditional medicinal utilization of the plant. And also the results
were compared with Indomethacin (10mg/kg) administered group of animals. Phytochemical screening of the methanolic extract revealed the presence of alkaloids,
flavonoids, sterols, carbohydrates and saponins.
Abstract: Purpose: The objective of the study was to select a suitable polymer for immobilization of pancreatic porcine lipase by entrapment method and to evaluate the kinetic properties of immobilized enzyme with free enzyme.
Method:. Enzyme was immobilized by entrapment method using calcium alginate and barium alginate polymers. Lipase activity was determined by titrimetric assay procedure. Km and Vmax were determined with Michaelis Menton Equation.
Result: The present work demonstrated that calcium alginate beads loaded with enzyme is more stable at high temperature and has excellent Vmax and Km in comparison with barium alginate beads.. Compare to immobilized enzyme free enzyme could not withstand high temperature.
Conclusion: Sodium alginate polymer is an excellent carrier for entrapment of pancreatic porcine lipase.
Abstract: Abstract
Purpose: To study the effect of the methanolic extract of Urena lobata Linn. on invitro immunostimulant activity.Method: Different concentrations (5-100µg/ml) of methanolic extract ofUrena lobata was subjected for its immunomodulatory activity using human blood by phagocytosis.Result: This study revealed that the methanolic extract of Urena lobata Linn. has phagocytosis and intracellular killing potency of human neutrophils at different concentration.Conclusion:Urena lobata Linn posses’ immunomodulatory property.
Abstract:
In the present study cassia fistula (Caesalpinaceae) bark was extracted with water. The extracts were vacuum dried to yield Aqueous Extract (AQET). The extracts were evaluated for hepatoprotective activity against Carbon tetrachloride (CCl4) induced liver damage at 250 mg/kg and 500 mg/kg dose level. The biochemical parameters observed in serum were total bilirubin, Alkaline phosphatase (ALP), Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT) levels and total protein. Aspartate transaminase (AST), Alanine Transaminase (ALT) and total protein levels in liver were also evaluated. Histopathological study on the liver tissue was also performed. The extracts exhibited dose dependant reduction in total bilirubin, ALP, SGOT, SGPT, AST, ALT and increase in total protein (serum and liver) levels. The extract treated groups shows mild hepatatocytic damage compared to the CCl4 treated group. CONCLUSION: Cassia fistulal attenuates the hepatotoxic effect of CCl4.
