// +author:a albini +author:albini var _ajax_res = { hits: 13, first: 0, results: [ {userid:"nicola.zanini", "refid":28,"attachment":"","articletype":"inproceedings","sectionheading":"","title":"New Methods of Treating the Pancreatic Fistulas: The Use of Sclerosing Substances","year":"2004","author":"Zanini N, Piccoli L, Casadei R, Albini Riccioli L, Calculli L, Bassi F, Minni F","booktitle":"","editor":"","pages":"","organization":"JOP. J Pancreas (Online) 2004; 5(5 Suppl):451. ","address":"","publisher":"","doi":"","pubmed":"","pdflink":"","urllink":"http:\/\/www.joplink.net\/","abstract":"","note":"","tags":""} , {userid:"antlagana", "refid":"302","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Addressing the safety of hyaluronic acid dermal filler injections during the SARS CoV-2 pandemic worldwide vaccination.","year":"2021","author":"Giovanni Buzzaccarini, Marco Borin, Bianca Diffidenti, Simona Var\u00ec, Milvia Di Gioia, Maria Albini, Marco Noventa, Antonio Simone Lagan\u00e0","journal":"Journal of plastic, reconstructive & aesthetic surgery : JPRAS","volume":"","number":"","pages":"","month":"Sep","doi":"10.1016\/j.bjps.2021.08.037","pubmed":"34588152","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":302,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1878-0539","isi":"","key":"Buzzaccarini2021","howpublished":""} , {userid:"antlagana", "refid":"350","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Los Deline copolyamide filler for breast and buttock augmentation. The position statement of the Italian Aesthetic Medicine Association (AMEI).","year":"2022","author":"Giovanni Buzzaccarini, Antonio Simone Lagan\u00e0, Marco Borin, Simona Var\u00ec, Giovanni Tulipano, Stefano Vertu\u00e8, Marco Noventa, Maria Albini, Franco Vercesi","journal":"Journal of plastic, reconstructive & aesthetic surgery : JPRAS","volume":"75","number":"8","pages":"2831-2870","month":"Aug","doi":"10.1016\/j.bjps.2022.06.047","pubmed":"35817710","pdflink":"","urllink":"","abstract":"","note":"","tags":"Breast,Buttocks,Esthetics,Humans,Mammaplasty","weight":350,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1878-0539","isi":"","key":"Buzzaccarini2022","howpublished":""} , {userid:"mario.barzaghi", "refid":"4","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Structural study of the solid-state photoaddition reaction of arylidenoxindoles","year":"2000","author":" Milanesio M, Viterbo D, Albini A, Fasani E, Bianchi R, Barzaghi M","journal":"J Org Chem","volume":"65","number":"11","pages":"3416-3425","month":"Jun","doi":"10.1021\/jo991873i","pubmed":"10843625","pdflink":"","urllink":"","abstract":"The photochemistry of isomeric 2-furyliden- and benzylidenoxindoles (2H-indol-2-ones) is examined. In solution E-Z isomerization is the only process via the excited singlet state (which fluoresces in glassy solution at 77 K and not at room temperature). In the crystalline state, the two (Z) derivatives are photostable, in accordance with the prediction based on the structural determination of the furylidene derivative, which adopts the unreactive Schmidt's gamma type arrangement. The (E) furylidene derivative (1a) gives efficiently (Phi = 0.3) the head-to-tail dimer, as indicated by the crystal structure, which is of the reactive alpha type, in full accord with the topochemical principles. In contrast, the corresponding benzylidene (1b) derivative reacts sluggishly (Phi < 0. 01) and mainly gives polymers, despite the fact that crystal structure determination shows that it likewise pertains to the alpha type and complies with the topochemical rules. The difference in reactivity is explained on the basis of (i) the twist of the phenyl ring with respect to the indole plane, and (ii) the higher overall cohesion energy and the lower interaction energy between facing molecules, as found from the charge density analysis for the crystals of 1b in comparison to those of 1a. This evidences a further stringent requirement for the occurrence of topochemical photodimerizations.","note":"","tags":""} , {userid:"camillo.rosano", "articletype":"article","pages":"1129-1145","author":"A Albini, C Rosano, G Angelini, A Amaro, A I Esposito, S Maramotti, D M Noonan, U Pfeffer","year":"2014","title":"Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors.","month":"","journal":"Current medicinal chemistry","publisher":"","volume":"21","number":"9","note":"","tags":"","booktitle":"","editor":"","abstract":"Observations on the role of ovarian hormones in breast cancer growth, as well as interest in contraception, stimulated research into the biology of estrogens. The identification of the classical receptors ER\u03b1 and ER\u03b2 and the transmembrane receptor GPER and the resolution of the structure of the ligand bound to its receptor established the principal molecular mechanisms of estrogen action. The presence of estrogen-like compounds in many plants used in traditional medicine or ingested as food ingredients, phytoestrogens, as well as the estrogenic activities of many industrial pollutants and pesticides, xenoestrogens, have prompted investigations into their role in human health. Phyto- and xenoestrogens bind to the estrogen receptors with a lower affinity than the endogenous estrogens and can compete or substitute the hormone. Xenoestrogens, which accumulate in the body throughout life, are believed to increase breast cancer risk, especially in cases of prenatal and prepuberal exposure whereas the role of phytoestrogens is still a matter of debate. At present, the application of phytoestrogens appears to be limited to the treatment of post-menopausal symptoms in women where the production of endogenous estrogens has ceased. In this review we discuss chemistry, structure and classification, estrogen signaling and the consequences of the interactions of estrogens, phytoestrogens and xenoestrogens with their receptors, the complex interactions of endogenous and exogenous ligands, the evaluation of the health risks related to xenoestrogens, and the perspectives toward the synthesis of potent third generation selective estrogen receptor modulators (SERMs).","address":"","school":"","issn":"1875-533X","doi":"","isi":"","pubmed":"24304271","key":"Albini2014","howpublished":"","urllink":"","refid":88,"weight":88} , {userid:"p.larghero", "refid":"20","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Glycogen synthase kinase 3beta regulates cell death induced by synthetic triterpenoids.","year":"2008","author":"Roberta Ven\u00e8, Patrizia Larghero, Giuseppe Arena, Michael B Sporn, Adriana Albini, Francesca Tosetti","journal":"Cancer research","volume":"68","number":"17","pages":"6987-6996","month":"Sep","doi":"10.1158\/0008-5472.CAN-07-6362","pubmed":"18757413","pdflink":"","urllink":"","abstract":"The induction of programmed cell death in premalignant or malignant cancer cells by chemopreventive agents could be a valuable tool to control prostate cancer initiation and progression. In this work, we present evidence that the C-28 methyl ester of the synthetic oleanane triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) induces cell death in androgen-responsive and unresponsive human prostate cancer cell lines at nanomolar and low micromolar concentrations. CDDO-Me induced caspase-3, caspase-8, and caspase-9 activation; poly(ADP-ribose) polymerase cleavage; internucleosomal DNA fragmentation; and loss of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction in PC3 and DU145 cells. However, caspase-3 and caspase-8 inhibition by Z-DEVD-fmk and Z-IETD-fmk, respectively, or general caspase inhibition by BOC-D-fmk or Z-VAD-fmk did not rescue loss of cell viability induced by CDDO-Me, suggesting the activation of additional caspase-independent mechanisms. Interestingly, CDDO-Me induced inactivating phosphorylation at Ser(9) of glycogen synthase kinase 3beta (GSK3beta), a multifunctional kinase that mediates essential events promoting prostate cancer development and acquisition of androgen independence. The GSK3 inhibitor lithium chloride and, more effectively, GSK3 gene silencing sensitized PC3 and DU145 prostate cancer cells to CDDO-Me cytotoxicity. These data suggest that modulation of GSK3beta activation is involved in the cell death pathway engaged by CDDO-Me in prostate cancer cells.","note":"","tags":"Adenocarcinoma,Apoptosis,Caspases,Cell Line, Tumor,Dose-Response Relationship, Drug,Enzyme Activation,Glycogen Synthase Kinase 3,Glycogen Synthase Kinase 3 beta,Humans,Male,Prostatic Neoplasms,RNA Interference,Triterpenes","weight":20,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1538-7445","isi":"","key":"Ven\u00e82008","howpublished":""} , {userid:"camillo.rosano", "articletype":"article","pages":"","author":"Adriana Agnese Amaro, Alessia Isabella Esposito, Valentina Mirisola, Arta Mehilli, Camillo Rosano, Douglas Noonan, Adriana Albini, Ulrich Pfeffer, Giovanna Angelini","year":"2013","title":"Endocrine disruptor agent Nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells.","month":"Jun","journal":"Current medicinal chemistry","publisher":"","volume":"","number":"","note":"","tags":"","booktitle":"","editor":"","abstract":"Several substances widely dispersed in the environment including hormones, industrial by-products and pollutants exert hormone like activity affecting steroid-responsive physiological systems. These compounds, named endocrine disruptors are suspected to affect the mammalian reproductive system. However it is still unclear whether these substances are able to elicit estrogen like activity at the low concentrations encountered in the environment. Here we compare the effects of the endocrine disruptor nonylphenol with the effects elicited by 17-\u03b2-estradiol on gene transcription in the human breast cancer cell line MCF7. The correlation of the nonylphenol induced gene expression alterations with a reference profile of estradiol treated cells shows that nonylphenol at a concentration of 100 nM exerts a significant effect on estrogen responsive gene transcription in MCF7 cells. Most of the genes regulated by 17-\u03b2-estradiol respond to the nonylphenol in the same direction though to a much lesser extent. Molecular modeling of the potential interaction of nonylphenol with the estrogen receptor \u03b1 shows that nonylphenol is likely to bind to the estrogen receptor \u03b1.","address":"","school":"","issn":"1875-533X","doi":"","isi":"","pubmed":"23862621","key":"Amaro2013","howpublished":"","urllink":"","refid":83} , {userid:"andrea.faini", "refid":"330","repocollections":"","attachment":"","_thumb":"","articletype":"inproceedings","sectionheading":"","title":"An ICT and mobile health integrated approach to optimize patients\u2019 education on hypertension and its management by physicians : The Patients Optimal Strategy of Treatment(POST) pilot study","year":"2016","author":"F Albini, X Liu, C Torlasco, D Soranna, A Faini, R Ciminaghi, A Celsi, M Benedetti, A Zambon, M di Rienzo, G Parati","booktitle":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","editor":"IEEE","pages":"517-520","organization":"","address":"","publisher":"","doi":"10.1109\/EMBC.2016.7590753","pubmed":"28324932","pdflink":"","urllink":"http:\/\/ieeexplore.ieee.org\/document\/7590753\/","abstract":"Introduction: Uncontrolled hypertension is largely attributed to unsatisfactory doctor\u2019s engagement in its optimal management and to poor patients\u2019 compliance to therapeutic interventions. ICT and mobile Health solutions might improve these conditions, being widely available and providing highly effective communication strategies. Objective: To evaluate whether ICT and mobile Health tools are able to improve hypertension control by improving doctors\u2019 engagement and by increasing patients\u2019 education and involvement, and their compliance to lifestyle modification and prescribed drug therapy. Methods: In a pilot study, we have included 690 treated hypertensive patients with uncontrolled office blood pressure (BP), consecutively recruited by 9 general practitioners over 3 months. Patients were alternatively assigned to routine management based on repeated office visits or to an integrated ICT-based Patients Optimal Strategy for Treatment (POST) system including Home BP monitoring teletransmission, a dedicated web-based platform for patients\u2019 management by physicians (Misuriamo platform), and a smartphone mobile application (Eurohypertension APP, E-APP), over a follow-up of 6 months. BP values, demographic and clinical data were collected at baseline and at all follow-up visits (at least two). BP control and cardiovascular risk level have been evaluated at the beginning and at the end of the study. Results: 89 patients did not complete the follow-up, thus data analysis was carried out in 601 of them (303 patients in the POST group and 298 in the control group). Office BP control (\\textless;149\/90 mmHg) was 40.0% in control group, and 72.3% in POST group at 6 month follow-up. At the same time Home BP control (\\textless;135\/85 mmHg average of 6 days) in POST group was 87.5%. Conclusion: this pilot study suggests that ICT based tools might be effective in improving hypertension management, implementing positive patients\u2019 involvem- nt with better adherence to treatment prescriptions and providing the physicians with dynamic control of patients\u2019 home BP measurements, resulting in lesser clinical inertia.","note":"","tags":"Antihypertensive Agents, Biomedical monitoring, biomedical telemetry, Blood pressure, Blood Pressure, blood pressure measurement, cardiovascular risk level, clinical data, data analysis, demographic data, diseases, Drugs, Education, eurohypertension app, Female, home blood pressure monitoring, Humans, Hypertension, hypertension management, ICT-based tool, Information and Communications Technology, integrated ICT-based POST system, Life Style, lifestyle modification, Male, Middle Aged, Mobile Applications, Mobile communication, mobile health integrated approach, mobile Health tool, Patient Compliance, patient education, Patient Education as Topic, patient monitoring, Patients Optimal Strategy of Treatment, Physicians, Pilot Projects, POST pilot study, prescribed drug therapy, smart phones, smartphone mobile application, telemedicine, Telemedicine, teletransmission, Web-based platform","weight":330,"month":"aug","journal":"","volume":"","number":"","school":"","issn":"","isi":"","key":"albini_ict_2016","howpublished":" C\\"} , {userid:"thomasnguyen", "refid":"22","repocollections":"","attachment":"","_thumb":"","articletype":"inproceedings","sectionheading":"","title":"Abstract 12311 : A New Score to Differentiate Idiopathic\/Heritable Pulmonary Arterial Hypertension From Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction","year":"2017","author":"Fabio Dardi, Nikita Tanese, Sergio Caravita, Andrea Rinaldi, Celine Dewachter, Enrico Gotti, Thomas Nguyen, Enrico Monti, Alessandra Albini, Massimiliano Palazzini, Alessandra Manes, Jean Luc Vachiery, Nazzareno Gali\u0102\u00a8","booktitle":"American Heart Association's 2017 Scientific Sessions and Resuscitation Science Symposium","editor":"","pages":"","organization":"","address":"","publisher":"","doi":"","pubmed":"","pdflink":"","urllink":"http:\/\/circ.ahajournals.org\/content\/136\/Suppl_1\/A12311","abstract":"","note":"","tags":"Pulmonary hypertension, Diastolic function, Heart failure, Pulmonary circulation, Pulmonary heart disease","weight":22,"journal":"Circulation","volume":"136","number":"Suppl 1","month":"nov","school":"","issn":"0009-7322, 1524-4539","isi":"","key":"dardi_abstract_2017","howpublished":"http:\/\/circ.ahajournals.org\/content\/136\/Suppl_1\/A12311"} , {userid:"p.larghero", "refid":"21","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression.","year":"2007","author":"Patrizia Larghero, Roberta Ven\u00e8, Simona Minghelli, Giorgia Travaini, Monica Morini, Nicoletta Ferrari, Ulrich Pfeffer, Douglas M Noonan, Adriana Albini, Roberto Benelli","journal":"Carcinogenesis","volume":"28","number":"5","pages":"1008-1020","month":"May","doi":"10.1093\/carcin\/bgl233","pubmed":"17127716","pdflink":"","urllink":"","abstract":"Lipoic acid (LA) is a sulfated antioxidant produced physiologically as a coenzyme of the pyruvate dehydrogenase complex; it is currently used for treatment of non-insulin-dependent diabetes to favor the cellular uptake of glucose. We have previously described the angiopreventive potential of molecules sharing common features with LA: N-acetyl cysteine, epigallocatechin-3-gallate and xanthohumol. To expand these studies, we have tested the capacity of LA to modulate angiogenesis in tumor growth using a Kaposi's sarcoma model. Endothelial cells exposed to LA displayed a dose-dependent reduction of cell migration and a time-dependent modulation of the phosphorylation of key signaling molecules. In vivo, LA efficiently repressed angiogenesis in matrigel plugs and KS-Imm tumor growth. We analyzed modulation of gene expression in endothelial cells treated with LA for 5 h (early response), finding a mild anti-apoptotic, antioxidant and anti-inflammatory response. A group of LA-targeted genes was selected to perform real-time polymerase chain reaction time-lapse experiments. The long-term gene regulation (48 h and 4 days) shows higher rates of modulation as compared with the array data, confirming that LA is able to switch the regulation of several genes linked to cell survival, inflammation and oxidative stress. LA induced the production of tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) in KS-Imm and activin-A in KS-Imm and endothelial cells; these factors show anti-angiogenic activity in vivo contributing to explain the inhibitory effect of LA on neovascularization. According to our data, LA has promising anti-angiogenic properties, though its influence on central metabolic pathways should suggest more caution about its widespread and not prescribed use at pharmacological doses.","note":"","tags":"Anti-Inflammatory Agents,Apoptosis,Biological Assay,Cell Movement,Cell Proliferation,Dose-Response Relationship, Drug,Endothelial Cells,Endothelium, Vascular,Gene Expression Regulation, Neoplastic,Neovascularization, Pathologic,Oligonucleotide Array Sequence Analysis,Oxidative Stress,Phosphorylation,Polymerase Chain Reaction,Sarcoma, Kaposi,Thioctic Acid,Tumor Cells, Cultured","weight":21,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0143-3334","isi":"","key":"Larghero2007","howpublished":""} ] } ; ajaxResultsLoaded(_ajax_res);