// +author:a alsultan +author:alsultan 
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{userid:"ndutta1", "articletype":"article","pages":"1535-1537","author":"Noton K Dutta, Abdullah Alsultan, Charles A Peloquin, Petros C Karakousis","year":"2013","title":"Preliminary pharmacokinetic study of repeated doses of rifampin and rifapentine in guinea pigs.","month":"Mar","journal":"Antimicrobial agents and chemotherapy","publisher":"","volume":"57","number":"3","note":"","tags":"","booktitle":"","editor":"","abstract":"Substitution of rifapentine (RFP) for rifampin (RIF) in the standard antituberculous regimen reduces the time required to cure chronic tuberculosis (TB) infection in mice, but not in guinea pigs. In order to gain insight into these discrepant findings, we conducted a steady-state pharmacokinetic (PK) study in healthy guinea pigs to study the metabolism and autoinduction of RIF and RFP. Both RFP and RIF 25-desacetyl metabolites (desRFP and desRIF, respectively), were detected at low concentrations in the serum of guinea pigs. The metabolite concentrations in guinea pigs are much lower than those seen in humans at steady state.","address":"","school":"","issn":"1098-6596","doi":"10.1128\/AAC.01933-12","isi":"","pubmed":"23295923","key":"Dutta2013","howpublished":"","urllink":"","refid":95}
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{userid:"MohrejO", "refid":14,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Incidence and predictors of surgical site infections following foot and ankle surgery","year":"2017","author":"Nader S Al-Kenani, Abdulaziz S Alsultan, Mariam A Alosfoor, Manal I Bahkali, Omar A Al-Mohrej\r\n","journal":"Journal of Musculoskeletal Surgery and Research","volume":"1","number":"1","pages":"6-9","month":"","doi":"10.4103\/jmsr.jmsr_11_17","pubmed":"","pdflink":"http:\/\/www.journalmsr.com\/article.asp?issn=WKMP-0145;year=2017;volume=1;issue=1;spage=6;epage=9;aulast=Al-Kenani;type=2","urllink":"http:\/\/www.journalmsr.com\/article.asp?issn=WKMP-0145;year=2017;volume=1;issue=1;spage=6;epage=9;aulast=Al-Kenani","abstract":"","note":"","tags":"","weight":14}
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{userid:"ndutta1", "articletype":"article","pages":"3910-3916","author":"Noton K Dutta, Abdullah Alsultan, Thomas J Gniadek, Deborah A Belchis, Michael L Pinn, Khisimuzi E Mdluli, Eric L Nuermberger, Charles A Peloquin, Petros C Karakousis","year":"2013","title":"Potent rifamycin-sparing regimen cures Guinea pig tuberculosis as rapidly as the standard regimen.","month":"Aug","journal":"Antimicrobial agents and chemotherapy","publisher":"","volume":"57","number":"8","note":"","tags":"","booktitle":"","editor":"","abstract":"Strategies involving new drug combinations, as well as new uses of existing drugs, are urgently needed to reduce the time required to cure patients with drug-sensitive or multidrug-resistant (MDR) tuberculosis (TB). We compared the sterilizing activity of the standard first-line antitubercular regimen, rifampin-isoniazid-pyrazinamide (RHZ), with that of the novel regimen PA-824-moxifloxacin-pyrazinamide (PaMZ), which is currently being studied in clinical trials (NCT01498419), in the guinea pig model of chronic TB infection, in which animals develop necrotic granulomas histologically resembling their human counterparts. Guinea pigs were aerosol infected with \u223c2 log10 bacilli of wild-type Mycobacterium tuberculosis H37Rv, and antibiotic treatment was initiated 6 weeks after infection. Separate groups of animals received RHZ, PaMZ, or single or two-drug components of the latter regimen administered at human-equivalent doses 5 days\/week for a total of 8 weeks. Relapse rates were assessed 3 months after discontinuation of treatment to determine the sterilizing activity of each combination regimen. PaMZ given at human-equivalent doses was safe and well tolerated for the entire treatment period and rendered guinea pig lungs culture negative more rapidly than RHZ did. After 1 month of treatment, 80% and 50% of animals in the RHZ and PaMZ groups, respectively, had lung culture-positive relapse. Both combination regimens prevented microbiological relapse when administered for a total of 2 months. Our data support the use of PaMZ as a novel isoniazid- and rifamycin-sparing regimen suitable for treatment of both drug-sensitive TB and MDR-TB.","address":"","school":"","issn":"1098-6596","doi":"10.1128\/AAC.00761-13","isi":"","pubmed":"23733473","key":"Dutta2013","howpublished":"","urllink":"","refid":97}
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