// +author:a amici +author:amici var _ajax_res = { hits: 9, first: 0, results: [ {userid:"maurizio.ferrarin", "articletype":"article","pages":"583-592","author":"Stefano Negrini, Barbara Piovanelli, Cinzia Amici, Valter Cappellini, Gabriele Bovi, Maurizio Ferrarin, Fabio Zaina, Alberto Borboni","year":"2016","title":"Trunk motion analysis: a systematic review from a clinical and methodological perspective.","month":"Aug","journal":"European journal of physical and rehabilitation medicine","publisher":"","volume":"52","number":"4","note":"","tags":"Adult,Aged,Back Pain,Biomechanical Phenomena,Female,Humans,Lumbar Vertebrae,Male,Middle Aged,Motion,Movement,Posture,Range of Motion, Articular,Spine,Thoracic Vertebrae","booktitle":"","editor":"","abstract":"This systematic literature review aims to check the current state of affairs of non-gait-related optoelectronic trunk movement analysis; results have been analyzed from a clinical and a methodological perspective.","address":"","school":"","issn":"1973-9095","doi":"","isi":"","pubmed":"27455950","key":"Negrini2016","howpublished":"","urllink":"","refid":290,"weight":290} , {userid:"scastellano", "articletype":"article","pages":"69-80","author":"Marco De Amici, Paola Conti, Clelia Dallanoce, Laurent Kassi, Sabrina Castellano, Giorgio Stefancich, Carlo De Micheli","year":"2000","title":"Synthesis and pharmacological characterization of new analogs of broxaterol","month":"","journal":"Med. Chem. Res.","publisher":"","volume":"10","number":"2","note":"CAN 133:296394 xD;Heterocyclic Compounds (More Than One Hetero Atom) xD;76596-57-1 (Broxaterol) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (prepn. and beta 1 and beta 2 adrenergic receptor activities of broxaterol analogs); 115697-55-7P; 115697-57-9P; 115697-60-4P; 301168-33-2P; 301168-34-3P; 301168-35-4P; 301168-36-5P; 301168-37-6P; 301168-38-7P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and beta 1 and beta 2 adrenergic receptor activities of broxaterol analogs); 684-88-8; 2028-63-9 (3-Butyn-2-ol); 5471-68-1; 14630-40-1 (Bis(trimethylsilyl)acetylene); 76596-55-9; 135325-36-9 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. and beta 1 and beta 2 adrenergic receptor activities of broxaterol analogs); 5930-98-3P; 68659-04-1P; 301168-22-9P; 301168-23-0P; 301168-24-1P; 301168-26-3P; 301168-27-4P; 301168-28-5P; 301168-29-6P; 301168-30-9P; 301168-31-0P; 301168-32-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and beta 1 and beta 2 adrenergic receptor activities of broxaterol analogs); 301168-25-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and beta 1 and beta 2 adrenergic receptor activities of broxaterol analogs)","tags":"Adrenoceptor agonists,Adrenoceptor antagonists (beta 1-,prepn. and beta 1 and beta 2 adrenergic receptor activities of broxaterol analogs),Adrenoceptor antagonists (beta 2-,broxaterol analog prepn adrenergic receptor activity,isoxazolemethanol amino prepn adrenergic receptor activity","booktitle":"","editor":"","abstract":"A series of isoxazole derivs. structurally related to broxaterol has been prepd. and tested for their potency to beta 1 and beta 2 adrenergic receptors. At variance with broxaterol, none of the tested compds. displayed agonistic activity. The 3-isopropenyl deriv. is the most potent antagonist both in the trachea and atria prepns.","address":"","school":"","issn":"1054-2523","doi":"","isi":"","pubmed":"","key":"DeAmici2000","howpublished":"","urllink":"","refid":31} , {userid:"giavarina", "articletype":"article","pages":"379-381","author":"Francesca Martino, Ilenia Filippi, Davide Giavarina, Gianpaolo Amici, Massimo de Cal, Manish Kaushik, Maria Pia Rodighiero, Carlo Crepaldi, Claudio Ronco","year":"2013","title":"Neutrophil gelatinase-associated lipocalin in peritoneal effluent: evaluation in peritoneal dialysis patients in basal condition.","month":"Jul\/Aug","journal":"Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis","publisher":"","volume":"33","number":"4","note":"","tags":"Acute-Phase Proteins,Aged,C-Reactive Protein,Cross-Sectional Studies,Female,Ferritins,Humans,Lipocalins,Male,Middle Aged,Multivariate Analysis,Peritoneal Dialysis,Proto-Oncogene Proteins","booktitle":"","editor":"","abstract":"In the present study, we assessed expression of neutrophil gelatinase-associated lipocalin (NGAL) in peritoneal effluent (pNGAL) from peritoneal dialysis (PD) patients, and we evaluated factors that might affect its level in basal conditions.","address":"","school":"","issn":"1718-4304","doi":"10.3747\/pdi.2011.00288","isi":"","pubmed":"23284073","key":"Martino2013","howpublished":"","urllink":"","refid":62,"weight":62} , {userid:"scastellano", "articletype":"article","pages":"2741-2751","author":"C Dallanoce, M De Amici, G Carrea, F Secundo, S Castellano, C De Micheli","year":"2000","title":"A chemoenzymatic approach to the synthesis of the stereoisomers of a beta -adrenergic receptor antagonist","month":"","journal":"Tetrahedron Asymmetry","publisher":"","volume":"11","number":"13","note":"CAN 133:309859 xD;Heterocyclic Compounds (More Than One Hetero Atom) xD;267236-53-3P; 267236-54-4P Role: BPN (Biosynthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.); 91376-49-7P; 267236-50-0P; 267236-51-1P; 267236-52-2P; 301670-75-7P Role: BPN (Biosynthetic preparation), PUR (Purification or recovery), RCT (Reactant), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.); 301670-76-8P; 301670-77-9P Role: BPN (Biosynthetic preparation), RCT (Reactant), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.); 9001-62-1 (Lipase) Role: CAT (Catalyst use), USES (Uses) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.); 497-06-3 (3-Butene-1,2-diol); 3282-30-2 (Pivaloyl chloride); 5471-68-1 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.); 177032-63-2P; 177032-64-3P; 191800-37-0P; 301670-78-0P; 301670-79-1P; 301670-80-4P; 301670-81-5P; 301670-82-6P; 301670-83-7P; 301670-84-8P; 301670-85-9P; 301670-86-0P; 301670-87-1P; 301670-88-2P; 301670-89-3P; 301670-90-6P; 301670-91-7P; 301670-92-8P; 301670-93-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.); 62214-39-5P; 86106-09-4P; 301670-95-1P; 301670-97-3P; 301670-99-5P; 301671-01-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.)","tags":"Resolution (kinetic,prepn. of stereoisomers of Delta 2-isoxazoline via enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc.),enzyme catalyst kinetic resoln unsatd secondary alc,isoxazoline enantiomer prepn","booktitle":"","editor":"","abstract":"The four stereoisomers of Delta 2-isoxazoline I, a beta -adrenergic receptor antagonist structurally related to Falintolol, were prepd. by an enzyme-catalyzed kinetic resoln. of the unsatd. secondary alc. CH2:CHCH(OH)CH2OSiPh2CMe3, followed by its cycloaddn. to pyruvonitrile oxide. Through this strategy, diastereomeric amino alcs. (+)-I\/(-)-I and (-)-2a\/(+)-2b were obtained in 99 and 92% enantiomeric excess, resp. The abs. configuration to the target compds. was assigned via chem. correlation to the enantiomers of epoxides 4a and 4b, whose stereochem. had been previously established.","address":"","school":"","issn":"0957-4166","doi":"","isi":"","pubmed":"","key":"Dallanoce2000","howpublished":"","urllink":"","refid":30} , {userid:"elena.ambrosino", "refid":"4","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Timely DNA vaccine combined with systemic IL-12 prevents parotid carcinomas before a dominant-negative p53 makes their growth independent of HER-2\/neu expression.","year":"2006","author":"Pannellini T, Spadaro M, Di Carlo E, Ambrosino E, Iezzi M, Amici A, Lollini PL, Forni G, Cavallo F, Musiani P.","journal":"Journal of Immunology","volume":"176","number":"12","pages":"7695-703","month":"Jun 15","doi":"","pubmed":"16751417","pdflink":"","urllink":"","abstract":"Double transgenic mice overexpressing the transforming rat HER-2\/neu oncogene and the mutated p53, with both dominant-negative and a gain-of-function properties, display early aggressive and metastasizing parotid tumors. Multiple acinar and ductal hyperplasia foci overexpressing the HER-2\/neu gene product are evident at wk 5 and progress to poorly differentiated carcinoma by wk 7. Mice die before wk 18 with invasive carcinomas and multiple metastases that no longer express HER-2\/neu. A combination of repeated electroporations of plasmids coding for the extracellular and transmembrane domains of the rat HER-2\/neu receptor with systemic IL-12 administrations started when the parotids that present diffuse hyperplasia protected all female and 50% of the male mice until the close of the experiment at wk 40. This combined treatment began when multifocal in situ carcinomas that were already present cured 33% of the females and 25% of the males. The most prominent immunologic features associated with the antitumor protection were the production of high titers of anti-HER-2\/neu Abs and the nonappearance of cell-mediated cytotoxic reactivity. In conclusion, anti-HER-2\/neu vaccination combined with systemic IL-12 control parotid carcinomas as far as p53 mutation makes their growth independent of HER-2\/neu expression.","note":"","tags":""} , {userid:"luciano.saso", "articletype":"article","pages":"17-25","author":"M G Leone, H H Abdel, G Gennaro, S Amici, D Conte, F Romanelli, M Latini, A Isidori, L Saso, B Silvestrini","year":"2001","title":"Changes of lipocalin type prostaglandin D-synthase in the seminal plasma of subfertile man.","month":"Jul\/Aug","journal":"Research communications in molecular pathology and pharmacology","publisher":"","volume":"110","number":"1-2","note":"","tags":"Electrophoresis, Polyacrylamide Gel,Humans,Infertility, Male,Intramolecular Oxidoreductases,Lipocalins,Male,Semen,Severity of Illness Index","booktitle":"","editor":"","abstract":"It was proposed that lipocalin type prostaglandin D synthase (L-PGD-S), a bifunctional protein both synthesizing PGD2 and transporting retinoids and other lipophilic ligands, could be involved in the development and the maturation of sperm. In the present study, the seminal plasma (SP) of 59 adult males was analyzed by standard WHO methods and immunoblotting, using a monospecific polyclonal antibody directed against L-PGD-S. Briefly, aliquots of SP (2.5 microl), were fractionated by polyacrylamide electrophoresis in the presence of sodium dodecyl sulfate, the blots were stained and densitometrically analyzed. To obtain quantitative data, the aliquot of SP was selected within the linear part of the dose\/band intensity curve and a proper quality control was analyzed in all blots to normalize the intensity of the bands of different experiments. A significant reduction (p<0.05) of the L-PGD-S levels was observed in severe oligozoospermic patients compared to normozoospermic subjects and a significant correlation between L-PGD-S levels and sperm concentration was found, as reported by other authors. Further studies are warranted to evaluate the possible diagnostic and pharmacological applications of these observations.","address":"","school":"","issn":"1078-0297","doi":"","isi":"","pubmed":"12090353","key":"Leone2001","howpublished":"","urllink":"","refid":76} , {userid:"claudia.cerella", "articletype":"article","pages":"1609-1611","author":"Maria D'Alessio, Claudia Cerella, Carla Amici, Caterina Pesce, Simona Coppola, Claudia Fanelli, Milena De Nicola, Silvia Cristofanon, Giovanna Clavarino, Antonio Bergamaschi, Andrea Magrini, Giampiero Gualandi, Lina Ghibelli","year":"2004","title":"Glutathione depletion up-regulates Bcl-2 in BSO-resistant cells.","month":"Oct","journal":"FASEB J","publisher":"","volume":"18","number":"13","note":"","tags":"Apoptosis,Buthionine Sulfoximine,Cell Line, Tumor,Cell Survival,Drug Resistance, Neoplasm,Glutathione,Humans,Proto-Oncogene Proteins c-bcl-2,RNA, Messenger,U937 Cells,Up-Regulation","booktitle":"","editor":"","abstract":"Glutathione depletion by inhibition of its synthesis with buthionine sulfoximine (BSO) is a focus of the current research in antitumor therapy, BSO being used as chemosensitizer. We had previously shown that two human tumor cell lines (U937 and HepG2) survive to treatment with BSO: BSO can elicit an apoptotic response, but the apoptotic process is aborted after cytochrome c release and before caspase activation, suggesting the development of an adaptive response (FASEB J., 1999, 13, 2031-2036). Here, we investigate the mechanisms of such an adaptation. We found that following BSO, U937 up-regulate Bcl-2 mRNA and protein levels, by a mechanism possibly involving NF-kappaB transcription factor; the increase in protein level is limited by a rapid decay of Bcl-2 in BSO-treated cells, suggesting that redox imbalance speeds up Bcl-2 turnover. BSO-dependent Bcl-2 up-regulation is associated with the ability to survive to BSO. Indeed, 1) its abrogation by CAPE or protein synthesis inhibition sensitizes U937 to BSO; 2) in a panel of four tumor lines, BSO-resistant (U937, HepG2, and HGB1) but not BSO-sensitive (BL41) cells can up-regulate Bcl-2 following GSH depletion; remarkably, only the latter are chemosensitized by BSO.","address":"","school":"","issn":"1530-6860","doi":"10.1096\/fj.04-1813fje","isi":"","pubmed":"15289449","key":"D'Alessio2004","howpublished":"","urllink":"","refid":16} , {userid:"elena.ambrosino", "refid":"2","attachment":"","articletype":"article","sectionheading":"","title":"Cure of mammary carcinomas in Her-2 transgenic mice through sequential stimulation of innate (neoadjuvant interleukin-12) and adaptive (DNA vaccine electroporation) immunity.","year":"2005","author":"Spadaro M, Ambrosino E, Iezzi M, Di Carlo E, Sacchetti P, Curcio C, Amici A, Wei WZ, Musiani P, Lollini PL, Cavallo F, Forni G.","journal":"Clinical Cancer Research","volume":"11","number":"5","pages":"1941-52","month":"Mar 1","doi":"","pubmed":"15756020","pdflink":"","urllink":"","abstract":"PURPOSE: Whereas neoadjuvant therapy is emerging as a treatment option in early primary breast cancer, no data are available on the use of antiangiogenic and immunomodulatory agents in a neoadjuvant setting. In a model of Her-2 spontaneous mammary cancer, we investigated the efficacy of neoadjuvant interleukin 12 (IL-12) followed by \"immune-surgery\" of the residual tumor. EXPERIMENTAL DESIGN: Female BALB\/c mice transgenic for the rat Her-2 oncogene inexorably develop invasive carcinomas in all their mammary glands by the 23rd week of age. Mice with multifocal in situ carcinomas received four weekly i.p. injections of 100 ng IL-12 followed by a 3-week rest. This course was given four times. A few mice additionally received DNA plasmids encoding portions of the Her-2 receptor electroporated through transcutaneous electric pulses. RESULTS: The protection elicited by IL-12 in combination with two DNA vaccine electroporations kept 63% of mice tumor-free. Complete protection of all 1-year-old mice was achieved when IL-12-treated mice received four vaccine electroporations. Pathologic findings, in vitro tests, and the results from immunization of both IFN-gamma and immunoglobulin gene knockout transgenic mice and of adoptive transfer experiments all show that IL-12 augments the B- and T-cell response elicited by vaccination and slightly decreases the number of regulatory T cells. In addition, IL-12 strongly inhibits tumor angiogenesis. CONCLUSIONS: In Her-2 transgenic mice, IL-12 impairs tumor progression and triggers innate immunity so markedly that DNA vaccination becomes effective at late points in time when it is ineffective on its own.","note":"","tags":""} , {userid:"domenico.deberardis", "articletype":"article","pages":"5-9","author":"Giuseppe Tavormina, Maurilio Giuseppe Maria Tavormina, Francesco Franza, Gino Aldi, Patrizia Amici, Marilisa Amorosi, Calogero Anzallo, Alba Cervone, Donatella Costa, Immacolata D'Errico, Domenico De Berardis, Wilma Di Napoli, Sandro Elisei, Barbara Felisio, Giovanna Ferella, Desiree Harnic, Maria Rosaria Juli, Gianluca Lisa, Antonella Litta, Salvatore Marcasciano, Annapaola Mazza, Efisia Meloni, Leonardo Mendolicchio, Maria Vincenza Min, Patrizia Moretti, Mariangela Perito, Maria Russiello, Jeanne Therese Sanna, Annarita Sidari, Ileana Sinisi, Barbara Solomita, Maria Grazia Spurio, Giuseppe Stranieri, Romina Tavormina, Antonella Vacca, Federica Vellante, Sharon Vitarisi, Yong-Wook Shin, Seockhoon Chung","year":"2020","title":"A New Rating Scale (SAVE-9) to Demonstrate the Stress and Anxiety in the Healthcare Workers During the COVID-19 Viral Epidemic.","month":"Sep","journal":"Psychiatria Danubina","publisher":"","volume":"32","number":"Suppl 1","note":"","tags":"Anxiety,Betacoronavirus,Coronavirus Infections,Health Personnel,Humans,Italy,Occupational Stress,Pandemics,Pneumonia, Viral","booktitle":"","editor":"","abstract":"The COVID-19 epidemic has been a major global public health problem during past months in Italy and in several other Countries and on the date of publication of this article, is still a serious public health problem. The health staff, engaged in the care of the sick and in the prevention of the spread of the infection have been subjected to a further increase in psychological difficulties and work-related stress, related to the workload for the continuous influx of sick and intense and close working shifts for the viral emergency. The SAVE-9 (Stress and Anxiety to Viral Epidemics - 9 items) scale has been developed as a tool for assessing work anxiety and stress in response to the viral epidemic of health professionals working to prevent the spread of the virus and to treat infected people.","address":"","school":"","issn":"0353-5053","doi":"","isi":"","pubmed":"32890353","key":"Tavormina2020","howpublished":"","urllink":"","refid":230,"weight":230} ] } ; ajaxResultsLoaded(_ajax_res);