// +author:b avalle +author:avalle 
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{userid:"alain.friboulet", "articletype":"article","pages":"80-88","author":"B Avalle, A Friboulet, D Thomas","year":"2000","title":"Catalysis by anti-idiotypic antibodies.","month":"","journal":"Chem Immunol","publisher":"","volume":"77","number":"","note":"","tags":"Acetylcholinesterase,Animals,Antibodies, Anti-Idiotypic,Antibodies, Catalytic,Antibodies, Monoclonal,Catalysis,Mice,Molecular Mimicry,beta-Lactamases","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"1015-0145","doi":"","isi":"","pubmed":"11706707","key":"Avalle2000","howpublished":"","urllink":"","refid":22}
,

{userid:"alain.friboulet", "refid":87,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Structure-function studies of a new generation of catalytic protein: an abzyme with a beta-lactamase activity.","year":"2000","author":"H D\u00e9bat, B Avalle, A Friboulet, D Thomas","journal":"Int J Biochromatogr","volume":"5","number":"","pages":"91-96","month":"","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":""}
,

{userid:"alain.friboulet", "refid":"104","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Structural and Functional Mise en Abyme.","year":"2019","author":"B Avalle, S Padiolleau-Lefevre, A Friboulet","journal":"Frontiers in molecular biosciences","volume":"6","number":"","pages":"","month":"11","doi":"10.3389\/fmolb.2019.00131","pubmed":"31850365","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":104,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"2296-889X","isi":"","key":"Avalle2019","howpublished":""}
,

{userid:"alain.friboulet", "refid":"56","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Enzymes and abzymes relationships.","year":"2000","author":"B. Avalle, A. Friboulet, D. Thomas","journal":"J. Molec. Catal. B","volume":"10","number":"","pages":"39-45","month":"","doi":"10.1016\/S1381-1177(00)00106-5 ","pubmed":"","pdflink":"","urllink":"","abstract":"Antibodies and enzymes are proteins that bind macromolecules and small natural and synthetic ligands with high specificity and high affinity. While enzymes have been perfecting their skills during evolution to reach very efficient structures for catalysis, antibody-binding sites evolve toward efficient structures for binding in a few weeks. The generation of antibodies bearing catalytic activities (abzymes) brings new insights in the understanding on the evolution of the catalytic function, and also on functions that the immune system could play in metabolism.","note":"","tags":""}
,

{userid:"alain.friboulet", "refid":"28","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"A possible role of catalytic antibodies in metabolism.","year":"1999","author":"A Friboulet, B Avalle, H D\u00e9bat, D Thomas","journal":"Immunol Today","volume":"20","number":"","pages":"474-475","month":"","doi":"","pubmed":"10500296","pdflink":"","urllink":"","abstract":"","note":"","tags":"Animals,Antibodies, Catalytic,Autoimmunity,Humans,Mice,beta-Lactamases","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0167-5699","isi":"","key":"Friboulet1999","howpublished":""}
,

{userid:"alain.friboulet", "refid":"30","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Screening of inhibitory monoclonal antibodies. A critical step for producing anti-idiotypic catalytic antibodies.","year":"1998","author":"B Avalle, A Friboulet, D Thomas","journal":"Ann N Y Acad Sci","volume":"864","number":"","pages":"118-130","month":"","doi":"","pubmed":"9928086","pdflink":"","urllink":"","abstract":"In accord with the original approach that we proposed, catalytic antibodies may be produced by using the anti-idiotypic pathway according to antigen\/antibody complementarity rules. The generation and screening of the idiotypic Ab1, the central point on which are anchored the interactions with both the antigen (enzyme) and the anti-idiotypic abzyme, represent a crucial step for the success of this approach. We herein propose to describe a strategy for which we have developed a number of assays, aiming at selecting the proper Ab1, with desired features, likely to elicit an anti-idiotypic catalytic antibody. beta-Lactamase from Bacillus cereus was chosen as the example illustrating our arguments.","note":"","tags":"Antibodies, Anti-Idiotypic,Antibodies, Catalytic,Antibodies, Monoclonal,Bacillus cereus,Binding Sites,Enzyme-Linked Immunosorbent Assay,Kinetics,Penicillin G,Protein Engineering,beta-Lactamases","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0077-8923","isi":"","key":"Avalle1998","howpublished":""}
,

{userid:"alain.friboulet", "refid":"31","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Functional mimicry: elicitation of a monoclonal anti-idiotypic antibody hydrolizing beta-lactams.","year":"1998","author":"B Avalle, D Thomas, A Friboulet","journal":"FASEB J","volume":"12","number":"","pages":"1055-1060","month":"","doi":"","pubmed":"9707178","pdflink":"","urllink":"","abstract":"Antigen mimicry by anti-idiotypic antibodies is investigated as a reliable strategy to achieve molecular imprinting of an enzymatic activity. A monoclonal anti-idiotypic antibody (Ab2-9G4H9) was elicited by using a monoclonal antibody (Ab1-7AF9) specific for the beta-lactamase active site. Catalytic features of Ab2 were characterized with beta-lactamase substrates. The antibody combining site appeared to have retained a part of the catalytic specificity. The relevance of the idiotypic mimicry concept for the generation of catalytic antibodies was further demonstrated by eliciting a third generation antibody (Ab3), which was shown to recognize beta-lactamase: the complete internal image properties of Ab2 9G4H9, including binding and catalytic properties, were thus checked.","note":"","tags":"Animals,Antibodies, Anti-Idiotypic,Antibodies, Monoclonal,Catalysis,Mice,Molecular Mimicry,Molecular Structure,beta-Lactamases,beta-Lactams","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0892-6638","isi":"","key":"Avalle1998","howpublished":""}
,

{userid:"alain.friboulet", "refid":"32","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Polyclonal catalytic anti-idiotypic antibodies with a beta-lactamase activity.","year":"1996","author":"B Avalle, D Mistro, D Thomas, A Friboulet","journal":"Ann N Y Acad Sci","volume":"799","number":"","pages":"172-175","month":"","doi":"","pubmed":"8958088","pdflink":"","urllink":"","abstract":"","note":"","tags":"Animals,Antibodies, Anti-Idiotypic,Antibodies, Catalytic,Antibodies, Monoclonal,Bacillus cereus,Binding Sites,Mice,Mice, Inbred BALB C,beta-Lactamases","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0077-8923","isi":"","key":"Avalle1996","howpublished":""}
,

{userid:"alain.friboulet", "refid":"26","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Catalytic mechanism of an abzyme displaying a beta-lactamase-like activity.","year":"2000","author":"B Avalle, H D\u00e9bat, A Friboulet, D Thomas","journal":"Appl Biochem Biotechnol","volume":"83","number":"","pages":"163-9","month":"","doi":"","pubmed":"10826957","pdflink":"","urllink":"","abstract":"A catalytic IgG (Ab2) displaying a beta-lactamase-like activity was previously obtained by using the antiidiotypic pathway: the particularity of this antibody is that it is a true antiidiotype of the beta-lactamase active site. We have previously demonstrated that this IgG has retained some of the structural information displayed by the beta-lactamase active site, evident from data that polyclonal anti-Ab2 antibodies (Ab3) recognize beta-lactamase. In this article, we investigated the catalytic mechanism of the abzyme compared to that of the enzyme. The experimental data allow us to hypothesize the catalytic residues required for catalysis.","note":"","tags":"Animals,Antibodies, Anti-Idiotypic,Antibodies, Catalytic,Bacillus cereus,Catalytic Domain,Immunoglobulin G,Kinetics,Mice,beta-Lactamases","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0273-2289","isi":"","key":"Avalle2000","howpublished":""}
,

{userid:"alain.friboulet", "refid":"29","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Antibody catalysis based on functional mimicry.","year":"1998","author":"B Avalle, V Zanin, D Thomas, A Friboulet","journal":"Appl Biochem Biotechnol","volume":"75","number":"","pages":"3-12","month":"","doi":"","pubmed":"10214693","pdflink":"","urllink":"","abstract":"Approaches aiming at eliciting antibodies (Abs) that catalyze specific chemical transformations are numerous. Most of the developed methods are based on the chemical steps of the reaction catalyzed rather than on the structure of known enzyme active sites. The authors have developed an approach that rests on the mimicry properties of the idiotypic network of immune regulation. Recent results, together with the existence of natural catalytic Abs in autoimmune diseases, indicate the need to better understand the regulation properties of immune response, in order to improve the efficiency of tailor-made catalytic Abs.","note":"","tags":"Animals,Antibodies, Anti-Idiotypic,Antibodies, Catalytic,Antibody Specificity,Catalysis,Humans,Molecular Mimicry,Structure-Activity Relationship","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0273-2289","isi":"","key":"Avalle1998","howpublished":""}
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