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{userid:"stefan.woehrl", "articletype":"article","pages":"1045-52","author":"W Hemmer, M Focke, D Kolarich, I B Wilson, F Altmann, S W\u00f6hrl, M G\u00f6tz, R Jarisch","year":"2001","title":"Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy","month":"","journal":"J Allergy Clin Immunol","publisher":"","volume":"108","number":"6","note":"21617257 xD;0091-6749 xD;Journal Article","tags":"Animal,Bee Venoms\/*immunology,Carbohydrates\/*immunology,Cross Reactions,Human,Hypersensitivity\/*immunology,Immunoglobulin E\/*blood,Insect Bites and Stings\/*immunology,Rabbits,Support, Non-U.S. Gov't,Wasp Venoms\/*immunology","booktitle":"","editor":"","abstract":"BACKGROUND: Up to 50% of patients with stinging-insect allergy have double-positive RAST results to honeybee and yellow jacket (YJ) venom. True double sensitization and crossreactivity through venom hyaluronidases are considered main reasons for this multiple reactivity. OBJECTIVE: We investigated the role of antibodies against cross-reactive carbohydrate determinants in venom double positivity. METHODS: CAP inhibition experiments were performed with crude oilseed rape (OSR) and timothy grass pollen extracts and a neoglycoprotein construct displaying a MUXF glycan, as present in pineapple-stem bromelain (MUXF-BSA). CAP to OSR was used as a rough measure for carbohydrate-specific IgE in individual sera. RESULTS: CAP results to OSR pollen were positive in 2 of 14 single-positive honeybee venom sera, 2 of 16 single-positive YJ venom sera, and 33 (80.5%) of 41 double-positive sera (P < .00001, chi(2) test). CAP inhibition was performed in 16 selected patients with a CAP class of 3 or higher to both venoms. In 9 of 11 patients with a highly positive CAP result to OSR (CAP score to OSR > CAP score to second venom), pollen extracts, MUXF-BSA, or both were able to completely inhibit IgE binding to one of the venoms, whereas this was not the case in 5 patients with a negative or weakly positive CAP result to OSR (CAP score to OSR < CAP score to second venom). CONCLUSIONS: The data suggest that carbohydrate-specific IgE is a major cause for the double positivity to honeybee and YJ venom seen in patients with Hymenoptera allergy. Because these antibodies may have low clinical relevance, they may severely impede the correct diagnosis of Hymenoptera venom allergy.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"Hemmer2001b","howpublished":"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11742287","urllink":"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11742287","refid":89}
,

{userid:"ohad.birk", "refid":"25","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.","year":"1996","author":"O S Birk, D C Douek, D Elias, K Takacs, H Dewchand, S L Gur, M D Walker, R van der Zee, I R Cohen, D M Altmann","journal":"Proc Natl Acad Sci U S A","volume":"93","number":"3","pages":"1032-1037","month":"Feb","doi":"","pubmed":"8577709","pdflink":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC40025\/pdf\/pnas01507-0079.pdf","urllink":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC40025\/?tool=pubmed","abstract":"A pathogenic role for self-reactive cells against the stress protein Hsp60 has been proposed as one of the events leading to autoimmune destruction of pancreatic beta cells in the diabetes of nonobese diabetic (NOD) mice. To examine this hypothesis, we generated transgenic NOD mice carrying a murine Hsp60 transgene driven by the H-2E alpha class II promoter. This would be expected to direct expression of the transgene to antigen-presenting cells including those in the thymus and so induce immunological tolerance by deletion. Detailed analysis of Hsp60 expression revealed that the endogenous gene is itself expressed strongly in thymic medullary epithelium (and weakly in cortex) yet fails to induce tolerance. Transgenic mice with retargeted Hsp60 showed overexpression of the gene in thymic cortical epithelium and in bone marrow-derived cells. Analysis of spontaneous T-cell responses to a panel of self and heterologous Hsp60 antigens showed that tolerance to the protein had not been induced, although responses to an immunodominant 437-460 epitope implicated in disease were suppressed, probably indicating an epitope shift. This correlated with changes in disease susceptibility: insulitis in transgenic mice was substantially reduced so that pathology rarely progressed beyond periislet infiltration. This was reflected in a substantial reduction in hyperglycemia and disease. These data indicate that T cells specific for some epitopes of murine Hsp60 are likely to be involved in the islet-cell destruction that occurs in NOD mice.","note":"","tags":"Animals,Chaperonin 60,Diabetes Mellitus, Type 1,Disease Susceptibility,Female,Genes, MHC Class II,Immunity, Cellular,Islets of Langerhans,Lymphocyte Activation,Male,Mice,Mice, Inbred C57BL,Mice, Inbred CBA,Mice, Inbred NOD,Mice, Transgenic,Polymerase Chain Reaction,Promoter Regions (Genetics),Recombinant Proteins,T-Lymphocytes,Thymus Gland","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0027-8424","key":"Birk1996","howpublished":""}
,

{userid:"ohad.birk", "refid":"28","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"The 60-kDa heat shock protein modulates allograft rejection.","year":"1999","author":"O S Birk, S L Gur, D Elias, R Margalit, F Mor, P Carmi, J Bockova, D M Altmann, I R Cohen","journal":"Proc Natl Acad Sci U S A","volume":"96","number":"9","pages":"5159-5163","month":"Apr","doi":"","pubmed":"10220435","pdflink":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC21833\/pdf\/pq005159.pdf","urllink":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC21833\/?tool=pubmed","abstract":"Allograft rejection is a process of immune reactivity triggered by foreign transplantation antigens. We now demonstrate that the 60-kDa heat shock protein (hsp60), a molecule that is identical in the donor and the recipient, can regulate allograft immunity. In wild-type mice, hsp60 expression was greatly enhanced in allografts being rejected. By using MHC class II (Ealpha) promoter hsp60 transgenic mice either as donors of skin with enhanced expression of hsp60, or as allograft recipients with decreased hsp60 autoimmunity, we found that augmented expression of mouse hsp60 in the allograft accelerated its rejection, whereas reduced autoimmunity to mouse hsp60 in graft recipients delayed the process. Moreover, in nontransgenic mice, therapeutic administration of hsp60 or hsp60 peptides, known to modulate naturally occurring hsp60 autoimmunity, led to delayed allograft rejection. Thus, we demonstrate that hsp60 expression and hsp60 autoimmunity can influence and modify the immune response to foreign antigens. Hence, autoimmunity to self-hsp60 epitopes is not necessarily an aberration, but may serve physiologically and therapeutically to modulate foreign immunity.","note":"","tags":"Animals,Autoimmunity,Chaperonin 60,Graft Rejection,Mice,Mice, Transgenic,Skin Transplantation,Transplantation, Homologous","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"0027-8424","key":"Birk1999","howpublished":""}
,

{userid:"esric", "refid":"18","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Simultaneous multi-spectral, single-photon fluorescence imaging using a plasmonic colour filter array.","year":"2021","author":"Peter W R Connolly, Jessica Valli, Yash D Shah, Yoann Altmann, James Grant, Claudio Accarino, Colin Rickman, David R S Cumming, Gerald S Buller","journal":"Journal of biophotonics","volume":"14","number":"7","pages":"","month":"07","doi":"10.1002\/jbio.202000505","pubmed":"33829644","pdflink":"","urllink":"","abstract":"We present the first realisation of simultaneous multi-spectral fluorescence imaging using a single-photon avalanche diode (SPAD) array, where the spectral unmixing is facilitated by a plasmonic metasurface mosaic colour filter array (CFA). A 64\u2009\u00d7\u200964 pixel format silicon SPAD array is used to record widefield fluorescence and brightfield data from four biological samples. A plasmonic metasurface composed of an arrangement of circular and elliptical nanoholes etched into an aluminium thin film deposited on a glass substrate provides the high transmission efficiency CFA, enabling a bespoke spectral unmixing algorithm to reconstruct high fidelity, full colour images from as few as \u223c3 photons per pixel. This approach points the way toward real-time, single-photon sensitive multi-spectral fluorescence imaging. Furthermore, this is possible without additional bulky components such as a filter wheel, prism or diffraction grating, nor the need for multiple sample exposures or multiple detectors.","note":"","tags":"Algorithms,Color,Microscopy, Fluorescence,Optical Imaging,Photons","weight":18,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1864-0648","isi":"","key":"Connolly2021","howpublished":""}
,

{userid:"peterbrenneisen", "refid":76,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner","year":"2020","author":"L Drews, M Zimmermann, P Westhoff, D Brilhaus, RE Poss, L Bergmann, C Wiek, P Brenneisen, RP Piekorz, T Mettler-Altmann, APM Weber, AS Reichert","journal":"Dis Model Mech","volume":"13","number":"","pages":"dmm047134","month":"","doi":"10.1242\/dmm.047134","pubmed":"32717801","pdflink":"","urllink":"","abstract":"Astrocyte dysfunction is a primary factor in hepatic encephalopathy (HE) impairing neuronal activity under hyperammonemia. In particular, the early events causing ammonia-induced toxicity to astrocytes are not well understood. Using established cellular HE models, we show that mitochondria rapidly undergo fragmentation in a reversible manner upon hyperammonemia. Further, in our analyses, within a timescale of minutes, mitochondrial respiration and glycolysis were hampered, which occurred in a pH-independent manner. Using metabolomics, an accumulation of glucose and numerous amino acids, including branched chain amino acids, was observed. Metabolomic tracking of 15N-labeled ammonia showed rapid incorporation of 15N into glutamate and glutamate-derived amino acids. Downregulating human GLUD2 [encoding mitochondrial glutamate dehydrogenase 2 (GDH2)], inhibiting GDH2 activity by SIRT4 overexpression, and supplementing cells with glutamate or glutamine alleviated ammonia-induced inhibition of mitochondrial respiration. Metabolomic tracking of 13C-glutamine showed that hyperammonemia can inhibit anaplerosis of tricarboxylic acid (TCA) cycle intermediates. Contrary to its classical anaplerotic role, we show that, under hyperammonemia, GDH2 catalyzes the removal of ammonia by reductive amination of \u03b1-ketoglutarate, which efficiently and rapidly inhibits the TCA cycle. Overall, we propose a critical GDH2-dependent mechanism in HE models that helps to remove ammonia, but also impairs energy metabolism in mitochondria rapidly.","note":"","tags":"brain energy metabolism, glutamate dehydrogenase, hepatic encephalopathy, hyperammonemia, mitochondria, TCA cycle","weight":76}
,

{userid:"timothymuller", "articletype":"article","pages":"1859-1871","author":"O Ciccarelli, T E Behrens, D R Altmann, R W Orrell, R S Howard, H Johansen-Berg, D H Miller, P M Matthews, A J Thompson","year":"2006","title":"Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis.","month":"Jul","journal":"Brain : a journal of neurology","publisher":"","volume":"129","number":"Pt 7","note":"","tags":"Adult,Aged,Algorithms,Amyotrophic Lateral Sclerosis,Anisotropy,Brain Mapping,Diffusion Magnetic Resonance Imaging,Disease Progression,Female,Humans,Image Processing, Computer-Assisted,Leg,Male,Middle Aged,Muscle Spasticity,Muscle, Skeletal,Pyramidal Tracts","booktitle":"","editor":"","abstract":"The goal of probabilistic tractography is to obtain a connectivity index along a white matter pathway that reflects fibre organization and is sensitive to pathological abnormalities contributing to disability. Here, we present the development of voxel-based connectivity measures along the tractography-derived corticospinal tract (CST). We investigated whether these connectivity measures are different in patients with amyotrophic lateral sclerosis (ALS) and correlate with the rate of disease progression. We also investigated whether fractional anisotropy (FA), which reflects directional coherence of fibre tracts, is reduced in the CST of ALS patients and relates to disease progression rate. Thirteen patients with probable or definite ALS and 19 healthy subjects were studied. The probabilistic tractography algorithm segmented the bilateral CST, along which FA and connectivity values were obtained. To take into account the asymmetric distribution of connectivity values, two summary statistic measures that focused on voxels with higher connectivity values were selected and then used in the analysis, together with the mean connectivity and the mean FA. To complete the analysis, the same summary measures for FA were included. Differences in all these indices between patients with moderate or rapid disease progression rate and controls were investigated using linear regression, adjusted for age and white matter fraction. The association between FA or connectivity in the CST and the disease progression rate was assessed using linear regression. Patients with a rapid disease progression rate had significantly lower summary connectivity measures than controls in the left CST, but there was only a borderline statistical difference in mean connectivity. Patients with rapid progression had a significantly lower mean FA, and any other FA measure, in both CSTs than controls. When only patients were considered, strong associations between the rate of disease progression and all the connectivity measures in the left CST were found (P-values between P < 0.001 and P = 0.002, partial correlation coefficients between -0.90 and -0.82). However, there was no evidence of an association between disease progression rate and any of the FA measures in the bilateral CST. Our findings suggest that FA and connectivity provide complementary information, since FA is sensitive to the detection of all the group differences, whereas the summary connectivity measures correlate with disease progression rate. The development of such connectivity measures raises their potential as markers of disease progression in ALS, and provides guidance for their use in other neurological diseases.","address":"","school":"","issn":"1460-2156","doi":"10.1093\/brain\/awl100","isi":"","pubmed":"16672290","key":"Ciccarelli2006","howpublished":"","urllink":"","refid":102,"weight":102}
,

{userid:"digby.f.warner", "articletype":"article","pages":"447-452","author":"Brian D Robertson, Danny Altmann, Clif Barry, Bill Bishai, Stewart Cole, Thomas Dick, Ken Duncan, Chris Dye, Sabine Ehrt, Hanif Esmail, Joanne Flynn, Richard Hafner, Gray Handley, Willem Hanekom, Paul van Helden, Gilla Kaplan, Stefan H E Kaufmann, Peter Kim, Christian Lienhardt, Valerie Mizrahi, Eric Rubin, Dirk Schnappinger, David Sherman, Jelle Thole, Omar Vandal, Gerhard Walzl, Digby Warner, Robert Wilkinson, Douglas Young","year":"2012","title":"Detection and treatment of subclinical tuberculosis.","month":"Nov","journal":"Tuberculosis (Edinburgh, Scotland)","publisher":"","volume":"92","number":"6","note":"","tags":"Antitubercular Agents,Bacterial Load,Biomarkers,Drug Design,Female,Humans,Immunization Programs,Latent Tuberculosis,Male,Models, Animal,Mycobacterium tuberculosis,South Africa,Tuberculosis,Tuberculosis Vaccines","booktitle":"","editor":"","abstract":"Reduction of active disease by preventive therapy has the potential to make an important contribution towards the goal of tuberculosis (TB) elimination. This report summarises discussions amongst a Working Group convened to consider areas of research that will be important in optimising the design and delivery of preventative therapies. The Working Group met in Cape Town on 26th February 2012, following presentation of results from the GC11 Grand Challenges in Global Health project to discover drugs for latent TB.","address":"","school":"","issn":"1873-281X","doi":"10.1016\/j.tube.2012.06.004","isi":"","pubmed":"22819716","key":"Robertson2012","howpublished":"","urllink":"","refid":84,"weight":84}
,

{userid:"sven.haller", "refid":"236","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals.","year":"2024","author":"Luigi Lorenzini, Lyduine E Collij, Niccol\u00f3 Tesi, Nat\u00e0lia Vilor-Tejedor, Silvia Ingala, Kaj Blennow, Christopher Foley, Giovanni B Frisoni, Sven Haller, Henne Holstege, Sven van der van der Lee, Pablo Martinez-Lage, Riccardo E Marioni, Daniel L McCartney, John O' Brien, Tiago Gil Oliveira, Pierre Payoux, Marcel Reinders, Craig Ritchie, Philip Scheltens, Adam J Schwarz, Carole H Sudre, Adam D Waldman, Robin Wolz, Gael Chatelat, Michael Ewers, Alle Meije Wink, Henk J M M Mutsaerts, Juan Domingo Gispert, Pieter Jelle Visser, Betty M Tijms, Andre Altmann, Frederik Barkhof","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","volume":"20","number":"9","pages":"6146-6160","month":"Sep","doi":"10.3390\/biomedicines9070781","pubmed":"39073684","pdflink":"","urllink":"","abstract":"Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine.","note":"","tags":"Humans,Alzheimer Disease,Endophenotypes,Biomarkers,Amyloid beta-Peptides,Female,Male,tau Proteins,Aged,Brain,Genetic Predisposition to Disease,Middle Aged,Magnetic Resonance Imaging,White Matter","weight":236,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1552-5279","isi":"","key":"Lorenzini2024","howpublished":""}
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{userid:"pauljamesbennie", "articletype":"article","pages":"","author":"M Dietrich, B M Peterson, P Albrecht, M Altmann, A J Barth, P J Bennie, R Bertram, N G Bochkarev, H Bock, J M Braun, A Burenkov, S Collier, L.-Z. Fang, O P Francis, A V Filippenko, C B Foltz, W Gaessler, C M Gaskell, M Geffert, K K Ghosh, R W Hilditch, R K Honeycutt, K Horne, J P Huchra, S Kaspi, M Kuemmel, K M Leighly, D C Leonard, Y F Malkov, V Mikhailov, H R Miller, A C Morrill, J Noble, P T O\u2019Brien, T D Oswalt, S P Pebley, M Pfeiffer, V I Pronik, B.-C. Qian, J W Robertson, A Robinson, K S Rumstay, J Schmoll, S G Sergeev, E A Sergeeva, A I Shapovalova, D R Skillman, S A Snedden, S Soundararajaperumal, G M Stirpe, J Tao, G W Turner, R M Wagner, S J Wagner, J Y Wei, H Wu, W Zheng, Z L Zou","year":"1999","title":"VizieR Online Data Catalog : 3C 390.3 BVRI and H photometry (Dietrich+, 1998)","month":"mar","journal":"VizieR Online Data Catalog","publisher":"","volume":"211","number":"","note":"","tags":"Active gal. nuclei, Photometry: UBVRI, Photometry: H-alpha, Photometry: H-beta, Photometry: H-gamma","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"","key":"ref1999yCat..21150185D","howpublished":"","urllink":"","refid":15,"weight":15}
,

{userid:"pauljamesbennie", "articletype":"article","pages":"185-202","author":"M Dietrich, B M Peterson, P Albrecht, M Altmann, A J Barth, P J Bennie, R Bertram, N G Bochkarev, H Bock, J M Braun, A Burenkov, S Collier, L.-Z. Fang, O P Francis, A V Filippenko, C B Foltz, W G\u00e4ssler, C M Gaskell, M Geffert, K K Ghosh, R W Hilditch, R K Honeycutt, K Horne, J P Huchra, S Kaspi, M K\u00fcmmel, K M Leighly, D C Leonard, Y F Malkov, V Mikhailov, H R Miller, A C Morrill, J Noble, P T O\u2019Brien, T D Oswalt, S P Pebley, M Pfeiffer, V I Pronik, B.-C. Qian, J W Robertson, A Robinson, K S Rumstay, J Schmoll, S G Sergeev, E A Sergeeva, A I Shapovalova, D R Skillman, S A Snedden, S Soundararajaperumal, G M Stirpe, J Tao, G W Turner, R M Wagner, S J Wagner, J Y Wei, H Wu, W Zheng, Z L Zou","year":"1998","title":"Steps toward Determination of the Size and Structure of the Broad-Line Region in Active Galactic Nuclei. XII. Ground-based Monitoring of 3C 390.3","month":"apr","journal":"\\apjs","publisher":"","volume":"115","number":"","note":"","tags":"GALAXIES: ACTIVE, GALAXIES: INDIVIDUAL ALPHANUMERIC: 3C 390.3, GALAXIES: SEYFERT, Galaxies: Active, Galaxies: Individual: Alphanumeric: 3C 390.3, Galaxies: Seyfert","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"","doi":"10.1086\/313085","isi":"","pubmed":"","key":"ref1998ApJS..115..185D","howpublished":"","urllink":"","refid":16,"weight":16}
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