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{userid:"piero.sismondi", "articletype":"article","pages":"712-713","author":"P F Conte, A Rubagotti, A Falcone, G Gardin, A Nicolin, P Pronzato, R Rosso, D Amadori, P Gentilini, P Sismondi","year":"1987","title":"Cytokinetic-based versus conventional chemotherapy in metastatic breast cancer: a randomized study.","month":"Jun","journal":"Chemioterapia","publisher":"","volume":"6","number":"2 Suppl","note":"","tags":"Antineoplastic Combined Chemotherapy Protocols,Breast Neoplasms,Clinical Trials as Topic,Cyclophosphamide,Diethylstilbestrol,Epirubicin,Female,Fluorouracil,Humans,Neoplasm Metastasis","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"0392-906X","doi":"","isi":"","pubmed":"3334664","key":"Conte1987","howpublished":"","urllink":"","refid":150}
,

{userid:"piero.sismondi", "refid":"23","attachment":"ref-23\/Switching to anastrozole versus continued tamoxifen 2006.pdf","articletype":"article","sectionheading":"","title":"Switching to anastrozole versus continued tamoxifen treatment of early breast cancer. Updated results of the Italian tamoxifen anastrozole (ITA) trial.","year":"2006","author":"F Boccardo, A Rubagotti, P Guglielmini, A Fini, G Paladini, M Mesiti, M Rinaldini, S Scali, M Porpiglia, C Benedetto, N Restuccia, F Buzzi, R Franchi, B Massidda, V Distante, D Amadori, P Sismondi","journal":"Ann Oncol","volume":"17 Suppl 7","number":"","pages":"vii10-vii14","month":"Jun","doi":"10.1093\/annonc\/mdl941","pubmed":"16760270","pdflink":"","urllink":"","abstract":"BACKGROUND: Tamoxifen, for many years the 'gold standard' in the adjuvant setting for the management of endocrine sensitive early breast cancer, is associated with an increased risk of endometrial cancer and other life-threatening events. Moreover, many women relapse during or after tamoxifen therapy due to the development of resistance. This provided the rationale for a switching trial with anastrozole, the updated results of which are reported here. PATIENTS AND METHODS: This trial investigated the efficacy of switching to anastrozole for women already receiving tamoxifen. After 2-3 years of tamoxifen treatment, postmenopausal, node-positive, ER-positive patients were randomized to receive either anastrozole 1 mg\/day or to continue tamoxifen, 20 mg\/day, giving a total duration of 5-years treatment. The primary end point was disease-free survival and secondary endpoints were event-free survival, overall survival and safety. RESULTS: A total of 448 patients were enrolled. At a median follow-up time of 64 months (range 12-93), 63 events had been reported in the tamoxifen group compared with 39 in the anastrozole group [HR 0.57 (95% CI 0.38-0.85) P = 0.005]. Relapse-free and overall survival were also longer in the anastrozole group [HR 0.56 (95% CI 0.35-0.89) P = 0.01 and 0.56 (95% CI 0.28-1.15) P = 0.1]. However, the latter difference was not statistically significant. Overall more patients in the anastrozole group experienced at least one adverse event (209 versus 151: P = 0.000). However, numbers of patients experiencing serious adverse events were comparable (37 versus 40, respectively: P = 0.7). CONCLUSIONS: Switching to anastrozole after the first 2-3 years of treatment was confirmed to improve event-free and relapse-free survival of postmenopausal, node-positive, ER-positive early breast cancer patients already receiving adjuvant tamoxifen.","note":"","tags":"Antineoplastic Agents, Hormonal,Aromatase Inhibitors,Breast Neoplasms,Chemotherapy, Adjuvant,Disease-Free Survival,Female,Follow-Up Studies,Humans,Nitriles,Postmenopause,Receptors, Estrogen,Selective Estrogen Receptor Modulators,Tamoxifen,Triazoles"}
,

{userid:"frezza.giovanni", "articletype":"article","pages":"166-171","author":"Alba A Brandes, Enrico Franceschi, Mario Ermani, Alicia Tosoni, Fiorenzo Albani, Roberta Depenni, Marina Faedi, Anna Pisanello, Girolamo Crisi, Benedetta Urbini, Claudio Dazzi, Luigi Cavanna, Claudia Mucciarini, Giuseppe Pasini, Stefania Bartolini, Gianluca Marucci, Luca Morandi, Elena Zunarelli, Serenella Cerasoli, Giorgio Gardini, Giovanni Lanza, Enrico Maria Silini, Silvio Cavuto, Agostino Baruzzi, A Baruzzi, F Albani, F Calbucci, R D'Alessandro, R Michelucci, A Brandes, V Eusebi, S Ceruti, E Fainardi, R Tamarozzi, E Emiliani, M Cavallo, E Franceschi, A Tosoni, F Fiorica, A Valentini, R Depenni, C Mucciarini, G Crisi, E Sasso, C Biasini, L Cavanna, D Guidetti, N Marcello, A Pisanello, A M Cremonini, G Guiducci, S de Pasqua, S Testoni, R Agati, G Ambrosetto, A Bacci, E Baldin, A Baldrati, E Barbieri, S Bartolini, E Bellavista, F Bisulli, E Bonora, F Bunkheila, V Carelli, M Crisci, P Dall'Occa, D de Biase, S Ferro, C Franceschi, G Frezza, V Grasso, M Leonardi, G Marucci, V Mazzocchi, L Morandi, B Mostacci, G Palandri, E Pasini, M Pastore Trossello, A Pession, M Ragazzi, P Riguzzi, R Rinaldi, S Rizzi, G Romeo, F Spagnolli, P Tinuper, C Trocino, S Cerasoli, M Dall'Agata, M Faedi, M Frattarelli, G Gentili, A Giovannini, P Iorio, U Pasquini, G Galletti, C Guidi, W Neri, A Patuelli, S Strumia, M Casmiro, A Gamboni, F Rasi, G Cruciani, P Cenni, C Dazzi, Ar Guidi, F Zumaglini, A Amadori, G Pasini, M Pasquinelli, E Pasquini, A Polselli, A Ravasio, B Viti, M Sintini, A Ariatti, F Bertolini, G Bigliardi, P Carpeggiani, F Cavalleri, S Meletti, P Nichelli, E Pettorelli, G Pinna, E Zunarelli, F Artioli, I Bernardini, M Costa, G Greco, R Guerzoni, C Stucchi, C Iaccarino, R Rizzi, G Zuccoli, P Api, F Cartei, E Fallica, E Granieri, F Latini, G Lelli, C Monetti, V Ramponi, A Saletti, R Schivalocchi, S Seraceni, M R Tola, B Urbini, C Giorgi, E Montanari, D Cerasti, P Crafa, I Dascola, I Florindo, S Mazza, F Servadei, Em Silini, P Torelli, P Immovilli, N Morelli, C Vanzo","year":"2014","title":"Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center?","month":"Dec","journal":"Neuro-oncology practice","publisher":"","volume":"1","number":"4","note":"","tags":"","booktitle":"","editor":"","abstract":"As yet, no population-based prospective studies have been conducted to investigate the incidence and clinical outcome of glioblastoma (GBM) or the diffusion and impact of the current standard therapeutic approach in newly diagnosed patients younger than aged 70 years.","address":"","school":"","issn":"2054-2577","doi":"10.1093\/nop\/npu021","isi":"","pubmed":"26034628","key":"Brandes2014","howpublished":"","urllink":"","refid":59,"weight":59}
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{userid:"chan.voong", "articletype":"article","pages":"","author":"Sophie Blein, Claire Bardel, Vincent Danjean, Lesley McGuffog, Sue Healey, Daniel Barrowdale, Andrew Lee, Joe Dennis, Karoline B Kuchenbaecker, Penny Soucy, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys,  , Ramunas Janavicius, Laima Tihomirova, Nadine Tung, Cecilia M Dorfling, Elizabeth J van Rensburg, Susan L Neuhausen, Yuan Chun Ding, Anne-Marie Gerdes, Bent Ejlertsen, Finn C Nielsen, Thomas Vo Hansen, Ana Osorio, Javier Benitez, Raquel Andr\u00e9s Conejero, Ena Segota, Jeffrey N Weitzel, Margo Thelander, Paolo Peterlongo, Paolo Radice, Valeria Pensotti, Riccardo Dolcetti, Bernardo Bonanni, Bernard Peissel, Daniela Zaffaroni, Giulietta Scuvera, Siranoush Manoukian, Liliana Varesco, Gabriele L Capone, Laura Papi, Laura Ottini, Drakoulis Yannoukakos, Irene Konstantopoulou, Judy Garber, Ute Hamann, Alan Donaldson, Angela Brady, Carole Brewer, Claire Foo, D Gareth Evans, Debra Frost, Diana Eccles,  , Fiona Douglas, Jackie Cook, Julian Adlard, Julian Barwell, Lisa Walker, Louise Izatt, Lucy E Side, M John Kennedy, Marc Tischkowitz, Mark T Rogers, Mary E Porteous, Patrick J Morrison, Radka Platte, Ros Eeles, Rosemarie Davidson, Shirley Hodgson, Trevor Cole, Andrew K Godwin, Claudine Isaacs, Kathleen Claes, Kim De Leeneer, Alfons Meindl, Andrea Gehrig, Barbara Wappenschmidt, Christian Sutter, Christoph Engel, Dieter Niederacher, Doris Steinemann, Hansjoerg Plendl, Karin Kast, Kerstin Rhiem, Nina Ditsch, Norbert Arnold, Raymonda Varon-Mateeva, Rita K Schmutzler, Sabine Preisler-Adams, Nadja Bogdanova Markov, Shan Wang-Gohrke, Antoine de Pauw, C\u00e9drick Lefol, Christine Lasset, Dominique Leroux, Etienne Rouleau, Francesca Damiola,  , H\u00e9l\u00e8ne Dreyfus, Laure Barjhoux, Lisa Golmard, Nancy Uhrhammer, Val\u00e9rie Bonadona, Val\u00e9rie Sornin, Yves-Jean Bignon, Jonathan Carter, Linda Van Le, Marion Piedmonte, Paul A DiSilvestro, Miguel de la Hoya, Trinidad Caldes, Heli Nevanlinna, Kristiina Aittom\u00e4ki, Agnes Jager, Ans Mw van den Ouweland, Carolien M Kets, Cora M Aalfs, Flora E van Leeuwen, Frans Bl Hogervorst, Hanne Ej Meijers-Heijboer,  , Jan C Oosterwijk, Kees Ep van Roozendaal, Matti A Rookus, Peter Devilee, Rob B van der Luijt, Edith Olah, Orland Diez, Alex Teul\u00e9, Conxi Lazaro, Ignacio Blanco, Jes\u00fas Del Valle, Anna Jakubowska, Grzegorz Sukiennicki, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Bjarni A Agnarsson, Christine Maugard, Alberto Amadori, Marco Montagna, Manuel R Teixeira, Amanda B Spurdle, William Foulkes, Curtis Olswold, Noralane M Lindor, Vernon S Pankratz, Csilla I Szabo, Anne Lincoln, Lauren Jacobs, Marina Corines, Mark Robson, Joseph Vijai, Andreas Berger, Anneliese Fink-Retter, Christian F Singer, Christine Rappaport, Daphne Geschwantler Kaulich, Georg Pfeiler, Muy-Kheng Tea, Mark H Greene, Phuong L Mai, Gad Rennert, Evgeny N Imyanitov, Anna Marie Mulligan, Gord Glendon, Irene L Andrulis, Sandrine Tchatchou, Amanda Ewart Toland, Inge Sokilde Pedersen, Mads Thomassen, Torben A Kruse, Uffe Birk Jensen, Maria A Caligo, Eitan Friedman, Jamal Zidan, Yael Laitman, Annika Lindblom, Beatrice Melin, Brita Arver, Niklas Loman, Richard Rosenquist, Olufunmilayo I Olopade, Robert L Nussbaum, Susan J Ramus, Katherine L Nathanson, Susan M Domchek, Timothy R Rebbeck, Banu K Arun, Gillian Mitchell, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Dominique Stoppa-Lyonnet, Gilles Thomas, Jacques Simard, Fergus J Couch, Kenneth Offit, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Sylvie Mazoyer, Catherine M Phelan, Olga M Sinilnikova, David G Cox","year":"2015","title":"An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.","month":"04","journal":"Breast cancer research : BCR","publisher":"","volume":"17","number":"","note":"","tags":"BRCA1 Protein,Breast Neoplasms,Female,Genes, BRCA2,Genes, Mitochondrial,Genetic Predisposition to Disease,Haplotypes,Heterozygote,Humans,Mutation,Phylogeny,Risk","booktitle":"","editor":"","abstract":"Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1\/2 mutation carriers.","address":"","school":"","issn":"1465-542X","doi":"10.1186\/s13058-015-0567-2","isi":"","pubmed":"25925750","key":"Blein2015","howpublished":"","urllink":"","refid":23,"weight":23}
,

{userid:"manuel.r.teixeira", "refid":"201","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.","year":"2015","author":"Sophie Blein, Claire Bardel, Vincent Danjean, Lesley McGuffog, Sue Healey, Daniel Barrowdale, Andrew Lee, Joe Dennis, Karoline B Kuchenbaecker, Penny Soucy, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys,  , Ramunas Janavicius, Laima Tihomirova, Nadine Tung, Cecilia M Dorfling, Elizabeth J van Rensburg, Susan L Neuhausen, Yuan Chun Ding, Anne-Marie Gerdes, Bent Ejlertsen, Finn C Nielsen, Thomas Vo Hansen, Ana Osorio, Javier Benitez, Raquel Andr\u00e9s Conejero, Ena Segota, Jeffrey N Weitzel, Margo Thelander, Paolo Peterlongo, Paolo Radice, Valeria Pensotti, Riccardo Dolcetti, Bernardo Bonanni, Bernard Peissel, Daniela Zaffaroni, Giulietta Scuvera, Siranoush Manoukian, Liliana Varesco, Gabriele L Capone, Laura Papi, Laura Ottini, Drakoulis Yannoukakos, Irene Konstantopoulou, Judy Garber, Ute Hamann, Alan Donaldson, Angela Brady, Carole Brewer, Claire Foo, D Gareth Evans, Debra Frost, Diana Eccles,  , Fiona Douglas, Jackie Cook, Julian Adlard, Julian Barwell, Lisa Walker, Louise Izatt, Lucy E Side, M John Kennedy, Marc Tischkowitz, Mark T Rogers, Mary E Porteous, Patrick J Morrison, Radka Platte, Ros Eeles, Rosemarie Davidson, Shirley Hodgson, Trevor Cole, Andrew K Godwin, Claudine Isaacs, Kathleen Claes, Kim De Leeneer, Alfons Meindl, Andrea Gehrig, Barbara Wappenschmidt, Christian Sutter, Christoph Engel, Dieter Niederacher, Doris Steinemann, Hansjoerg Plendl, Karin Kast, Kerstin Rhiem, Nina Ditsch, Norbert Arnold, Raymonda Varon-Mateeva, Rita K Schmutzler, Sabine Preisler-Adams, Nadja Bogdanova Markov, Shan Wang-Gohrke, Antoine de Pauw, C\u00e9drick Lefol, Christine Lasset, Dominique Leroux, Etienne Rouleau, Francesca Damiola,  , H\u00e9l\u00e8ne Dreyfus, Laure Barjhoux, Lisa Golmard, Nancy Uhrhammer, Val\u00e9rie Bonadona, Val\u00e9rie Sornin, Yves-Jean Bignon, Jonathan Carter, Linda Van Le, Marion Piedmonte, Paul A DiSilvestro, Miguel de la Hoya, Trinidad Caldes, Heli Nevanlinna, Kristiina Aittom\u00e4ki, Agnes Jager, Ans Mw van den Ouweland, Carolien M Kets, Cora M Aalfs, Flora E van Leeuwen, Frans Bl Hogervorst, Hanne Ej Meijers-Heijboer,  , Jan C Oosterwijk, Kees Ep van Roozendaal, Matti A Rookus, Peter Devilee, Rob B van der Luijt, Edith Olah, Orland Diez, Alex Teul\u00e9, Conxi Lazaro, Ignacio Blanco, Jes\u00fas Del Valle, Anna Jakubowska, Grzegorz Sukiennicki, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Bjarni A Agnarsson, Christine Maugard, Alberto Amadori, Marco Montagna, Manuel R Teixeira, Amanda B Spurdle, William Foulkes, Curtis Olswold, Noralane M Lindor, Vernon S Pankratz, Csilla I Szabo, Anne Lincoln, Lauren Jacobs, Marina Corines, Mark Robson, Joseph Vijai, Andreas Berger, Anneliese Fink-Retter, Christian F Singer, Christine Rappaport, Daphne Geschwantler Kaulich, Georg Pfeiler, Muy-Kheng Tea, Mark H Greene, Phuong L Mai, Gad Rennert, Evgeny N Imyanitov, Anna Marie Mulligan, Gord Glendon, Irene L Andrulis, Sandrine Tchatchou, Amanda Ewart Toland, Inge Sokilde Pedersen, Mads Thomassen, Torben A Kruse, Uffe Birk Jensen, Maria A Caligo, Eitan Friedman, Jamal Zidan, Yael Laitman, Annika Lindblom, Beatrice Melin, Brita Arver, Niklas Loman, Richard Rosenquist, Olufunmilayo I Olopade, Robert L Nussbaum, Susan J Ramus, Katherine L Nathanson, Susan M Domchek, Timothy R Rebbeck, Banu K Arun, Gillian Mitchell, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Dominique Stoppa-Lyonnet, Gilles Thomas, Jacques Simard, Fergus J Couch, Kenneth Offit, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Sylvie Mazoyer, Catherine M Phelan, Olga M Sinilnikova, David G Cox","journal":"Breast cancer research : BCR","volume":"17","number":"1","pages":"","month":"04","doi":"10.1186\/s13058-015-0567-2","pubmed":"25925750","pdflink":"","urllink":"","abstract":"Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1\/2 mutation carriers.","note":"","tags":"BRCA1 Protein,Breast Neoplasms,Female,Genes, BRCA2,Genes, Mitochondrial,Genetic Predisposition to Disease,Haplotypes,Heterozygote,Humans,Mutation,Phylogeny,Risk","weight":201,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1465-542X","isi":"","key":"Blein2015","howpublished":""}
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