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{userid:"francesco_checchi", "articletype":"article","pages":"","author":"F Checchi, R J Waldman, L F Roberts, A Ager, R Asgary, M T Benner, K Blanchet, G Burnham, E d\u2019Harcourt, J Leaning, M B F Massaquoi, E J Mills, R T Moresky, P Patel, B Roberts, M J Toole, B Woodruff, A B Zwi","year":"2016","title":"World Health Organization and emergency health : if not now, when?","month":"Jan","journal":"BMJ (Clinical research ed)","publisher":"BMJ Publishing Group","volume":"352","number":"","note":"","tags":"","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"0959-8138","doi":"10.1136\/bmj.i469","isi":"","pubmed":"","key":"checchi2016worldwhen","howpublished":"","urllink":"","refid":61,"weight":61}
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{userid:"rui.medeiros", "articletype":"article","pages":"","author":"S Forner, A C Martini, G A Prieto, C T Dang, C J Rodriguez-Ortiz, J M Reyes-Ruiz, L Trujillo-Estrada, C da Cunha, E J Andrews, J Phan, J Vu Ha, Avzd Chang, Y Levites, P E Cruz, R Ager, R Medeiros, M Kitazawa, C G Glabe, C W Cotman, T Golde, D Baglietto-Vargas, F M LaFerla","year":"2019","title":"Intra- and extracellular \u03b2-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus","month":"","journal":"","publisher":"","volume":"9","number":"1","note":"2045-2322 Forner, Stefania Orcid: 0000-0001-7977-4866 Martini, Alessandra C Orcid: 0000-0002-8447-6756 Prieto, G Aleph Dang, Cindy T Rodriguez-Ortiz, Carlos J Orcid: 0000-0003-2688-947x Reyes-Ruiz, Jorge Mauricio Trujillo-Estrada, Laura da Cunha, Celia Andrews, Elizabeth J Phan, Jimmy Vu Ha, Jordan Chang, Allissa V Z D Levites, Yona Cruz, Pedro E Ager, Rahasson Medeiros, Rodrigo Orcid: 0000-0002-9399-7852 Kitazawa, Masashi Glabe, Charles G Cotman, Carl W Golde, Todd Baglietto-Vargas, David Orcid: 0000-0003-1441-3175 LaFerla, Frank M P01 AG000538\/AG\/NIA NIH HHS\/United States R21 AG048506\/AG\/NIA NIH HHS\/United States U01AG046139\/U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)\/International Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Sci Rep. 2019 Nov 4;9(1):15936. doi: 10.1038\/s41598-019-52324-0.","tags":"Alzheimer Disease\/metabolism\/pathology Amyloid beta-Peptides\/genetics\/*metabolism Animals Cells, Cultured Dependovirus\/*genetics Gene Transfer Techniques Genetic Vectors\/genetics\/metabolism Hippocampus\/cytology\/*metabolism Maze Learning Memory\/*physiology Mice Mice, Inbred C57BL Neuronal Plasticity\/*physiology Peptide Fragments\/genetics\/*metabolism Synapses\/metabolism","booktitle":"","editor":"","abstract":"Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with dementia severity when compared with other pathological features of the disease. Nevertheless, the series of events that promote synaptic failure still remain under debate, as potential triggers such as \u03b2-amyloid (A\u03b2) can vary in size, configuration and cellular location, challenging data interpretation in causation studies. Here we present data obtained using adeno-associated viral (AAV) constructs that drive the expression of oligomeric A\u03b2 either intra or extracellularly. We observed that expression of A\u03b2 in both cellular compartments affect learning and memory, reduce the number of synapses and the expression of synaptic-related proteins, and disrupt chemical long-term potentiation (cLTP). Together, these findings indicate that during the progression AD the early accumulation of A\u03b2 inside neurons is sufficient to promote morphological and functional cellular toxicity, a phenomenon that can be exacerbated by the buildup of A\u03b2 in the brain parenchyma. Moreover, our AAV constructs represent a valuable tool in the investigation of the pathological properties of A\u03b2 oligomers both in vivo and in vitro.","address":"","school":"","issn":"2045-2322","doi":"10.1038\/s41598-019-52324-0","isi":"","pubmed":"","key":"ref44","howpublished":"","urllink":"","refid":420,"weight":420}
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