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{userid:"robbert.bredius", "articletype":"article","pages":"605-610","author":"J E Kist-van Holthe, D Bresters, Y M Ahmed-Ousenkova, C A Goedvolk, F C H Abbink, R Wolterbeek, R G M Bredius, E K J Pauwels, A J van der Heijden","year":"2005","title":"Long-term renal function after hemopoietic stem cell transplantation in children.","month":"Oct","journal":"Bone marrow transplantation","publisher":"","volume":"36","number":"7","note":"","tags":"Child,Cohort Studies,Creatinine,Female,Follow-Up Studies,Glomerular Filtration Rate,Hematopoietic Stem Cell Transplantation,Humans,Kidney,Kidney Failure, Chronic,Kidney Tubules,Male,Prevalence,Prospective Studies,Regression Analysis,Retrospective Studies,Time Factors,Transplantation Conditioning","booktitle":"","editor":"","abstract":"Glomerular function of all long-term survivors who underwent hemopoietic stem cell transplantation (HSCT) from 1991 to 1998 (study I, n=121) was studied retrospectively. In addition, we prospectively analyzed glomerular and tubular function of all long-term surviving children who received an HSCT between 1998 and 2000 (study II, n=41). We found a lower prevalence of children with chronic renal failure (CRF) post-HSCT in our more recent cohort (study II: 10%) as compared to the older cohort (study I: 24%) 5.0 (0.7 s.d.) and 7.6 (2.4 s.d.) year's post-HSCT, respectively. Furthermore, it seems that renal function may stabilize after 1-year post-HSCT. None of the patients required dialysis or antihypertensive medication at long-term follow-up. The sole predictor of CRF in our study was high serum creatinine pre-HSCT (P=0.007), while acute renal failure within 3 months after HSCT (P=0.08) only showed a trend towards predicting CRF. We could not confirm a relation of conditioning with irradiation with CRF post-HSCT, as was shown in several other pediatric and adult studies. Proximal and distal tubular dysfunction only occurred in a minority of long-time survivors of HSCT (3-12 and 9-13%, respectively) and had no clinical consequences.","address":"","school":"","issn":"0268-3369","doi":"10.1038\/sj.bmt.1705110","isi":"","pubmed":"16044134","key":"Kist-vanHolthe2005","howpublished":"","urllink":"","refid":"39","weight":"39"}
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