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{userid:"juan.montiel", "refid":"46","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Homology in amniote brain evolution: the rise of molecular evidence","year":"2018","author":"Montiel JF, Aboitiz F","journal":"Brain, Behavior and Evolution","volume":"","number":"","pages":"","month":"","doi":"10.1159\/000489116. 2018.","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":46}
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{userid:"juan.montiel", "refid":47,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Morphological evolution of the vertebrate forebrain. From mechanical to cellular processes","year":"2019","author":"F Aboitiz, J.F. Montiel","journal":"Evolution & Development","volume":"","number":"","pages":"","month":"","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":47}
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{userid:"juan.montiel", "articletype":"article","pages":"1-112","author":"F Aboitiz, J Montiel","year":"2007","title":"Origin and evolution of the vertebrate telencephalon, with special reference to the mammalian neocortex.","month":"","journal":"Adv Anat Embryol Cell Biol","publisher":"","volume":"193","number":"","note":"","tags":"Animals,Biological Evolution,Cerebral Cortex,Mammals,Models, Biological,Neocortex,Phylogeny,Telencephalon,Vertebrates","booktitle":"","editor":"","abstract":"","address":"","school":"","issn":"0301-5556","doi":"","isi":"","pubmed":"17595827","key":"Aboitiz2007","howpublished":"","urllink":"","refid":9}
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{userid:"juan.montiel", "refid":"45","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Olfaction, navigation and the origin of isocortex","year":"2015","author":"F Aboitiz, J Montiel","journal":"Frontiers in Neuroscience","volume":"9","number":"402","pages":"","month":"Oct","doi":"10.3389\/fnins.2015.00402","pubmed":"","pdflink":"","urllink":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2015.00402\/abstract","abstract":"There are remarkable similarities between the brains of mammals and birds in terms of microcircuit architecture, despite obvious differences in gross morphology and development. While in reptiles and birds the most expanding component (the dorsal ventricular ridge) displays an overall nuclear shape and derives from the lateral and ventral pallium, in mammals a dorsal pallial, six-layered isocortex shows the most remarkable elaboration. Regardless of discussions about possible homologies between mammalian and avian brains, a main question remains in explaining the emergence of the mammalian isocortex, because it represents a unique phenotype across amniotes. In this article, we propose that the origin of the isocortex was driven by behavioral adaptations involving olfactory driven goal-directed and navigating behaviors. These adaptations were linked with increasing sensory development, which provided selective pressure for the expansion of the dorsal pallium. The latter appeared as an interface in olfactory-hippocampal networks, contributing somatosensory information for navigating behavior. Sensory input from other modalities like vision and audition were subsequently recruited into this expanding region, contributing to multimodal associative networks.","note":"","tags":"Isocortical evolution, plasticity, Olfaction, Hippocampus, associative networks","weight":45}
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{userid:"juan.montiel", "articletype":"article","pages":"409-420","author":"F Aboitiz, J Montiel","year":"2003","title":"One hundred million years of interhemispheric communication: the history of the corpus callosum.","month":"Apr","journal":"Braz J Med Biol Res","publisher":"","volume":"36","number":"4","note":"","tags":"Animals,Biological Evolution,Corpus Callosum,Functional Laterality,Humans,Mammals,Neural Pathways,Reptiles,Visual Fields","booktitle":"","editor":"","abstract":"Analysis of regional corpus callosum fiber composition reveals that callosal regions connecting primary and secondary sensory areas tend to have higher proportions of coarse-diameter, highly myelinated fibers than callosal regions connecting so-called higher-order areas. This suggests that in primary\/secondary sensory areas there are strong timing constraints for interhemispheric communication, which may be related to the process of midline fusion of the two sensory hemifields across the hemispheres. We postulate that the evolutionary origin of the corpus callosum in placental mammals is related to the mechanism of midline fusion in the sensory cortices, which only in mammals receive a topographically organized representation of the sensory surfaces. The early corpus callosum may have also served as a substrate for growth of fibers connecting higher-order areas, which possibly participated in the propagation of neuronal ensembles of synchronized activity between the hemispheres. However, as brains became much larger, the increasingly longer interhemispheric distance may have worked as a constraint for efficient callosal transmission. Callosal fiber composition tends to be quite uniform across species with different brain sizes, suggesting that the delay in callosal transmission is longer in bigger brains. There is only a small subset of large-diameter callosal fibers whose size increases with increasing interhemispheric distance. These limitations in interhemispheric connectivity may have favored the development of brain lateralization in some species like humans.","address":"","school":"","issn":"0100-879X","doi":"","isi":"","pubmed":"12700818","key":"Aboitiz2003","howpublished":"","urllink":"","refid":17}
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{userid:"juan.montiel", "refid":"44","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Pallial patterning and the origin of the isocortex","year":"2015","author":"J F Montiel, F Aboitiz","journal":"Frontiers in Neuroscience","volume":"9","number":"377","pages":"","month":"Oct","doi":"10.3389\/fnins.2015.00377","pubmed":"","pdflink":"","urllink":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2015.00377\/full","abstract":"Together with a complex variety of behavioral, physiological, morphological, and neurobiological innovations, mammals are characterized by the development of an extensive isocortex (also called neocortex) that is both laminated and radially organized, as opposed to the brain of birds and reptiles. In this article, we will advance a developmental hypothesis in which the mechanisms of evolutionary brain growth remain partly conserved across amniotes (mammals, reptiles and birds), all based on Pax6 signaling or related morphogens. Despite this conservatism, only in mammals there is an additional upregulation of dorsal and anterior signaling centers (the cortical hem and the anterior forebrain, respectively) that promoted a laminar and a columnar structure into the neocortex. It is possible that independently, some birds also developed an upregulated dorsal pallium.","note":"","tags":"isocortical development, Pax6, Wnt, anthem, hem","weight":44}
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{userid:"juan.montiel", "refid":"34","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"From tetrapods to primates: conserved developmental mechanisms in diverging ecological adaptations.","year":"2012","author":"Francisco Aboitiz, Juan F Montiel","journal":"Progress in brain research","volume":"195","number":"","pages":"3-24","month":"","doi":"10.1016\/B978-0-444-53860-4.00001-5","pubmed":"22230620","pdflink":"","urllink":"","abstract":"Primates are endowed with a brain about twice the size that of a mammal with the same body size, and humans have the largest brain relative to body size of all animals. This increase in brain size may be related to the acquisition of higher cognitive skills that permitted more complex social interactions, the evolution of culture, and the eventual ability to manipulate the environment. Nevertheless, in its internal structure, the primate brain shares a very conserved design with other mammals, being covered by a six-layered neocortex that, although expands disproportionately to other brain components, it does so following relatively well-defined allometric trends. Thus, the most fundamental events generating the basic design of the primate and human brain took place before the appearance of the first primate-like animal. Presumably, the earliest mammals already displayed a brain morphology radically different from that of their ancestors and that of their sister group, the reptiles, being characterized by the presence of an incipient neocortex that underwent an explosive growth in subsequent mammal evolution. In this chapter, we propose an integrative hypothesis for the origin of the mammalian neocortex, by considering the developmental modifications, functional networks, and ecological adaptations involved in the generation of this structure during the cretaceous period. Subsequently, the expansion of the primate brain is proposed to have relied on the amplification of the same, or very similar, developmental mechanisms as those involved in its primary origins, even in different ecological settings.","note":"","tags":"Adaptation, Physiological,Animals,Biological Evolution,Brain,Humans,Mammals,Neural Pathways,Primates","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1875-7855","isi":"","key":"Aboitiz2012","howpublished":""}
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{userid:"juan.montiel", "refid":"30","repocollections":"","attachment":"","_thumb":"","articletype":"incollection","sectionheading":"","title":"Acetylcholinesterase-Rich Neurons in the Cerebral Cortex of the Rodent Octodon degus Cholinesterases","year":"2004","author":"Aldo Villal\u00f3n, Juan Montiel, Ricardo Garc\u00eda, Aboitiz F. ","booktitle":"Cholinesterases in the second millenium: biomolecular and pathological aspects","editor":"Inestrosa NC, Campos EO","pages":"","organization":"","address":"","publisher":"P. Universidad Cat\u00f3lica de Chile - FONDAP Biomedicina","isbn":"9789562991278","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":""}
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{userid:"juan.montiel", "articletype":"article","pages":"129-139","author":"F Aboitiz, D Morales, J Montiel","year":"2001","title":"The inverted neurogenetic gradient of the mammalian isocortex: development and evolution.","month":"Dec","journal":"Brain Res Brain Res Rev","publisher":"","volume":"38","number":"1-2","note":"","tags":"Animals,Biological Evolution,Cell Adhesion Molecules, Neuronal,Cell Movement,Cerebral Cortex,Cyclin-Dependent Kinase 5,Cyclin-Dependent Kinases,Extracellular Matrix Proteins,Humans,Nerve Tissue Proteins,Neuroglia,Neurons,Serine Endopeptidases,Signal Transduction","booktitle":"","editor":"","abstract":"In this paper we review recent evidence on the molecular control of cell migration in the isocortex, and present an hypothesis for the evolutionary origin of the inside-out neurogenetic gradient of this structure. We suggest that there are at least two key factors involved in the acquisition of the inside-out gradient: (i) the expression of the protein reelin, which arrests the migration of cortical plate cells by detaching them from the radial glial fiber. This permits younger neurons to use the same fiber to migrate past the previous neurons; and (ii) the second factor is an intracellular signaling pathway dependent on a cyclin-dependent protein kinase (Cdk5). Cdk5 may work by inhibiting N-cadherin mediated cell aggregation as young cells cross the cortical plate, permitting them to move to the more superficial layers. Interestingly, the mutation in Cdk5 affects the migration of only those cells belonging to superficial layers, which are considered to be an evolutionary acquisition of the mammalian isocortex.","address":"","school":"","issn":"","doi":"","isi":"","pubmed":"11750929","key":"Aboitiz2001","howpublished":"","urllink":"","refid":3}
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{userid:"juan.montiel", "articletype":"article","pages":"98-105","author":"R Olivares, J Montiel, F Aboitiz","year":"2001","title":"Species differences and similarities in the fine structure of the mammalian corpus callosum.","month":"Feb","journal":"Brain Behav Evol","publisher":"","volume":"57","number":"2","note":"","tags":"Animals,Axons,Cats,Cattle,Corpus Callosum,Dogs,Female,Functional Laterality,Horses,Male,Mammals,Microscopy, Electron,Nerve Fibers, Myelinated,Rabbits,Rats,Rats, Sprague-Dawley,Synaptic Transmission","booktitle":"","editor":"","abstract":"A cross-species ultrastructural study of the corpus callosum was performed in six domestic species: the rat, the rabbit, the cat, the dog, the horse and the cow. The results indicate cross-species conservatism in callosal fiber composition with a good interspecies relation between fiber number and brain size. Across species, increases in both brain size and callosal area indicate more callosal fibers, although less than expected from the estimated increase in cortical cell number. Within each species, the correlation between fiber number and brain weight tends to disappear, although in most cases a larger callosum implies a larger number of callosal fibers. The median fiber diameter was conservative across species (0.11-0.2 microm), indicating the maintenance of conduction velocity of most callosal fibers regardless of interhemispheric distance. Nevertheless, the maximal fiber diameters tended to be higher in species with larger brains. Therefore, there is a population of coarse-diameter fibers that tend to increase their diameter and conduction velocity with increasing brain size. However, allometric calculations suggest that the associated increase in velocity in these large fibers may not be sufficient to maintain a constant interhemispheric transmission time in different species.","address":"","school":"","issn":"0006-8977","doi":"","isi":"","pubmed":"11435670","key":"Olivares2001","howpublished":"","urllink":"","refid":4}
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