// +author:j adkins +author:adkins 
var _ajax_res = {
  hits: 10,

  first: 0,

  results: [

{userid:"debbie.adkins", "refid":5,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"The rat bone marrow micronucleus test - study design and statistical power.","year":"2009","author":"Hayes, J., Doherty, A.T., Adkins, D.J., Oldman, K.L., O'Donovan, M.R.","journal":" Mutagenesis","volume":"24","number":"","pages":"419-424","month":"","doi":"10.1093\/mutage\/gep024","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":5}
,

{userid:"debbie.adkins", "refid":6,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Corrigendum: The rat bone marrow micronucleus test - study design and statistical power (Correction to Mutagenesis, 24, pp419-424).","year":"2011","author":"Hayes, J., Doherty, A.T., Adkins, D.J., Oldman, K.L., O'Donovan, M.R.","journal":"Mutagenesis","volume":"26","number":"","pages":"687","month":"","doi":"10.1093\/mutage\/ger046 ","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":6}
,

{userid:"debbie.adkins", "refid":"4","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Retinal folding in the term rabbit fetus - developmental abnormality or fixation artifact?","year":"2008","author":"French, J., Halliday, J., Scott, M., Adkins, D., Liess, C., Waterton, J.C., Stewart, J.","journal":"Reproductive Toxicology","volume":"26","number":"","pages":"262-266","month":"","doi":"http:\/\/dx.doi.org\/10.1016\/j.reprotox.2008.08.008","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":4}
,

{userid:"debbie.adkins", "refid":8,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Effects of group housing on ECG assessment in conscious cynomolgus monkeys.","year":"2015","author":"Xing, G., Lu, J., Hu, M., Wang, S., Zhao, L., Zheng, W., Schofield, J., Oldman, K., Adkins, D., Yu, H., Platz, S., Ren, J., Skinner, M. ","journal":"Journal of Pharmacological and Toxicological methods","volume":"73","number":"","pages":"72-79","month":"","doi":"http:\/\/dx.doi.org\/10.1016\/j.vascn.2015.05.004","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":8}
,

{userid:"frauch", "articletype":"article","pages":"79-86","author":"M D Zeger, D Adkins, L A Fordham, K E White, E Schoenau, F Rauch, K J Loechner","year":"2007","title":"Hypophosphatemic rickets in opsismodysplasia","month":"","journal":"J Pediatr Endocrinol Metab","publisher":"","volume":"20","number":"1","note":"","tags":"","booktitle":"","editor":"","abstract":"BACKGROUND: Opsismodysplasia is a rare spondylo(epi)chondrodysplasia characteristized by delayed skeletal maturation and a constellation of dysplastic features. Although metaphyseal irregularities\/cupping have been noted, neither renal phosphate wasting nor rickets have previously been reported. OBJECTIVE: To evaluate hypophosphatemia and rickets in opsismodysplasia. PATIENTS: Two girls with opsismodysplasia presenting with hypophoshpatemia by 3 years of age. METHODS: Routine biochemistries to assess hypophosphatemia and renal phosphate wasting; radiographs (rachitic changes) and DEXA scan (BMD); FGF23 levels, PHEX and FGF23 gene analyses performed (Patient 1). RESULTS: Both children had hypophosphatemia, decreased TRP, and rickets. Oral phosphorus and calcitriol improved metaphyseal mineralization, yet serum phosphate levels remained relatively low and renal phosphate wasting persisted. PHEX and FGF23 gene analyses were negative, whereas serum FGF23 levels were markedly elevated in Patient 1. CONCLUSION: We now demonstrate an association between opsismodysplasia, hypophosphatemic rickets, and FGF23 elevation. Screening phosphorus levels may thus uncover a potentially treatable component of this disease.","address":"","school":"","issn":"0334-018X (Print)","doi":"","isi":"","pubmed":"","key":"Zeger2007","howpublished":"","urllink":"","refid":143}
,

{userid:"njsarlis", "articletype":"article","pages":"257-264","author":"Robert Haddad, Anne O'Neill, Guilherme Rabinowits, Roy Tishler, Fadlo Khuri, Douglas Adkins, Joseph Clark, Nicholas Sarlis, Jochen Lorch, Jonathan J Beitler, Sewanti Limaye, Sarah Riley, Marshall Posner","year":"2013","title":"Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial.","month":"Mar","journal":"The Lancet. Oncology","publisher":"","volume":"14","number":"3","note":"","tags":"Aged,Antineoplastic Combined Chemotherapy Protocols,Chemoradiotherapy,Cisplatin,Combined Modality Therapy,Disease-Free Survival,Female,Fluorouracil,Follow-Up Studies,Head and Neck Neoplasms,Humans,Induction Chemotherapy,Kaplan-Meier Estimate,Male,Middle Aged,Neoplasm Recurrence, Local,Neoplasm Staging,Taxoids","booktitle":"","editor":"","abstract":"The relative efficacy of the addition of induction chemotherapy to chemoradiotherapy compared with chemoradiotherapy alone for patients with head and neck cancer is unclear. The PARADIGM study is a multicentre open-label phase 3 study comparing the use of docetaxel, cisplatin, and fluorouracil (TPF) induction chemotherapy followed by concurrent chemoradiotherapy with cisplatin-based concurrent chemoradiotherapy alone in patients with locally advanced head and neck cancer.","address":"","school":"","issn":"1474-5488","doi":"10.1016\/S1470-2045(13)70011-1","isi":"","pubmed":"23414589","key":"Haddad2013","howpublished":"","urllink":"","refid":10,"weight":10}
,

{userid:"admin-2003", "articletype":"article","pages":"187-208","author":"Darren J Kriticos, Joel R Brown, Gunter F Maywald, Ian D Radford, D Mike Nicholas, Robert W Sutherst, Steve W Adkins","year":"2003","title":"SPAnDX : a process-based population dynamics model to explore management and climate change impacts on an invasive alien plant, Acacia nilotica","month":"","journal":"Ecological Modelling","publisher":"","volume":"163","number":"3","note":"","tags":"Acacia nilotica,Biological invasions,Cohort-based model,DYMEX,Global change,Population modelling,Simulation modelling,Wind,Climate change,Alien invasive species,population ecology,management,climate,decision support systems,weeds","booktitle":"","editor":"","abstract":"This paper describes a process-based metapopulation dynamics and phenology model of prickly acacia, Acacia nilotica, an invasive alien species in Australia. The model, SPAnDX, describes the interactions between riparian and upland sub-populations of A. nilotica within livestock paddocks, including the effects of extrinsic factors such as temperature, soil moisture availability and atmospheric concentrations of carbon dioxide. The model includes the effects of management events such as changing the livestock species or stocking rate, applying fire, and herbicide application. The predicted population behaviour of A. nilotica was sensitive to climate. Using 35 years daily weather datasets for five representative sites spanning the range of conditions that A. nilotica is found in Australia, the model predicted biomass levels that closely accord with expected values at each site. SPAnDX can be used as a decision-support tool in integrated weed management, and to explore the sensitivity of cultural management practices to climate change throughout the range of A. nilotica. The cohort-based DYMEX modelling package used to build and run SPAnDX provided several advantages over more traditional population modelling approaches (e.g. an appropriate specific formalism (discrete time, cohort-based, process-oriented), user-friendly graphical environment, extensible library of reusable components, and useful and flexible input\/output support framework).","address":"","school":"","issn":"0304-3800","doi":"Doi: 10.1016\/s0304-3800(03)00009-7","isi":"","pubmed":"","key":"Kriticos2003","howpublished":"http:\/\/www.sciencedirect.com\/science\/article\/B6VBS-47VYV5J-2\/2\/59d60daa408e05ee4ea64a9d56c1207c","urllink":"http:\/\/www.sciencedirect.com\/science\/article\/B6VBS-47VYV5J-2\/2\/59d60daa408e05ee4ea64a9d56c1207c","refid":47}
,

{userid:"debbie.adkins", "refid":"7","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"A multi-site comparison of in vivo safety pharmacology studies conducted to support ICH S7A & B regulatory submissions.","year":"2013","author":"L Ewart, A Milne, D Adkins, A Benjamin, R Bialecki, Y Chen, A-C Ericsson, S Gardner, C Grant, D Lengel, S Lindgren, S Lowing, L Marks, J Moors, K Oldman, M Pietras, H Prior, J Punton, W Redfern, R Salmond, M Skinner, M Some, A Stanton, M Swedberg, J Finch, J-P Valentin","journal":"Journal of Pharmacological and Toxicological Methods","volume":"68","number":"","pages":"30-43","month":"","doi":"http:\/\/dx.doi.org\/10.1016\/j.vascn.2013.04.008","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":7}
,

{userid:"admin-2007", "articletype":"article","pages":"1818-1837","author":"Z Liu, Y Wang, R Gallimore, F Gasse, T Johnson, P deMenocal, J Adkins, M Notaro, I C Prentice, J Kutzbach, R Jacob, P Behling, L Wang, E Ong","year":"2007","title":"Simulating the transient evolution and abrupt change of Northern Africa atmosphere-ocean-terrestrial ecosystem in the Holocene","month":"","journal":"Quaternary Science Reviews","publisher":"","volume":"26","number":"13-14","note":"","tags":"palaeobotany,palaeoclimate","booktitle":"","editor":"","abstract":"We present the first synchronously coupled transient simulation of the evolution of the northern Africa climate-ecosystem for the last 6500 years in a global general circulation ocean-atmosphere-terrestrial ecosystem model. The model simulated the major abrupt vegetation collapse in the southern Sahara at about 5\u00a0ka, consistent with the proxy records. Local precipitation, however, shows a much more gradual decline with time, implying a lack of strong positive vegetation feedback on annual rainfall during the collapse. The vegetation change in northern Africa is driven by local precipitation decline and strong precipitation variability. In contrast, the change of precipitation is dominated by internal climate variability and a gradual monsoonal climate response to orbital forcing. In addition, some minor vegetation changes are also simulated in different regions across northern Africa The model also simulated a gradual annual mean surface cooling in the subtropical North Atlantic towards the latest Holocene, as well as a reduced seasonal cycle of SST. The SST response is caused largely by the insolation forcing, while the annual mean cooling is also reinforced by the increased coastal upwelling near the east boundary. The increased upwelling results from a southward retreat of the North Africa monsoon system, and, in turn, an increased northeasterly trade wind. The simulated changes of SST and upwelling are also largely consistent with marine proxy records, albeit with a weaker magnitude in the model. The mismatch between the collapse of vegetation and gradual transition of rainfall suggests that the vegetation collapse is not caused by a strong positive vegetation feedback. Instead, it is suggested that the Mid-Holocene collapse of North African vegetation is caused mainly by a nonlinear response of the vegetation to a precipitation threshold in the presence of strong climate variability. The implication to the modeling and observations is also discussed.","address":"","school":"","issn":"0277-3791","doi":"DOI: 10.1016\/j.quascirev.2007.03.002","isi":"","pubmed":"","key":"Liu2007","howpublished":"http:\/\/www.sciencedirect.com\/science\/article\/B6VBC-4P83HNJ-1\/2\/3f7df7bf36a2b9b3b7eb91bcc21dd16e","urllink":"http:\/\/www.sciencedirect.com\/science\/article\/B6VBC-4P83HNJ-1\/2\/3f7df7bf36a2b9b3b7eb91bcc21dd16e","refid":87}
,

{userid:"h.tammen", "articletype":"article","pages":"3226-3245","author":"Gilbert S Omenn, David J States, Marcin Adamski, Thomas W Blackwell, Rajasree Menon, Henning Hermjakob, Rolf Apweiler, Brian B Haab, Richard J Simpson, James S Eddes, Eugene A Kapp, Robert L Moritz, Daniel W Chan, Alex J Rai, Arie Admon, Ruedi Aebersold, Jimmy Eng, William S Hancock, Stanley A Hefta, Helmut Meyer, Young-Ki Paik, Jong-Shin Yoo, Peipei Ping, Joel Pounds, Joshua Adkins, Xiaohong Qian, Rong Wang, Valerie Wasinger, Chi Yue Wu, Xiaohang Zhao, Rong Zeng, Alexander Archakov, Akira Tsugita, Ilan Beer, Akhilesh Pandey, Michael Pisano, Philip Andrews, Harald Tammen, David W Speicher, Samir M Hanash","year":"2005","title":"Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database.","month":"Aug","journal":"Proteomics","publisher":"","volume":"5","number":"13","note":"","tags":"Algorithms,Anticoagulants,Blood Proteins,Citric Acid,Computational Biology,DNA,Databases, Protein,Edetic Acid,Heparin,Humans,Immunoassay,Mass Spectrometry,Open Reading Frames,Pilot Projects,Proteomics,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","booktitle":"","editor":"","abstract":"HUPO initiated the Plasma Proteome Project (PPP) in 2002. Its pilot phase has (1) evaluated advantages and limitations of many depletion, fractionation, and MS technology platforms; (2) compared PPP reference specimens of human serum and EDTA, heparin, and citrate-anti-coagulated plasma; and (3) created a publicly-available knowledge base (www.bioinformatics.med.umich.edu\/hupo\/ppp; www.ebi.ac.uk\/pride). Thirty-five participating laboratories in 13 countries submitted datasets. Working groups addressed (a) specimen stability and protein concentrations; (b) protein identifications from 18 MS\/MS datasets; (c) independent analyses from raw MS-MS spectra; (d) search engine performance, subproteome analyses, and biological insights; (e) antibody arrays; and (f) direct MS\/SELDI analyses. MS-MS datasets had 15 710 different International Protein Index (IPI) protein IDs; our integration algorithm applied to multiple matches of peptide sequences yielded 9504 IPI proteins identified with one or more peptides and 3020 proteins identified with two or more peptides (the Core Dataset). These proteins have been characterized with Gene Ontology, InterPro, Novartis Atlas, OMIM, and immunoassay-based concentration determinations. The database permits examination of many other subsets, such as 1274 proteins identified with three or more peptides. Reverse protein to DNA matching identified proteins for 118 previously unidentified ORFs.We recommend use of plasma instead of serum, with EDTA (or citrate) for anticoagulation. To improve resolution, sensitivity and reproducibility of peptide identifications and protein matches, we recommend combinations of depletion, fractionation, and MS\/MS technologies, with explicit criteria for evaluation of spectra, use of search algorithms, and integration of homologous protein matches.This Special Issue of PROTEOMICS presents papers integral to the collaborative analysis plus many reports of supplementary work on various aspects of the PPP workplan. These PPP results on complexity, dynamic range, incomplete sampling, false-positive matches, and integration of diverse datasets for plasma and serum proteins lay a foundation for development and validation of circulating protein biomarkers in health and disease.","address":"","school":"","issn":"1615-9853","doi":"10.1002\/pmic.200500358","isi":"","pubmed":"16104056","key":"Omenn2005","howpublished":"","urllink":"","refid":13}
  ]
}

;
ajaxResultsLoaded(_ajax_res);