// +author:j apold +author:apold 
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{userid:"molven", "articletype":"article","pages":"515-524","author":"P R Nj\u00f8lstad, A Molven, J Apold, A Fjose","year":"1990","title":"The zebrafish homeobox gene hox-2.2: transcription unit, potential regulatory regions and in situ localization of transcripts.","month":"Feb","journal":"EMBO J","publisher":"","volume":"9","number":"2","note":"","tags":"Amino Acid Sequence,Animals,Base Sequence,Cloning, Molecular,Cyprinidae,Embryo, Nonmammalian,Genes, Homeobox,Genes, Regulator,Mice,Molecular Sequence Data,Nucleic Acid Hybridization,Sequence Homology, Nucleic Acid,Terminology as Topic,Transcription, Genetic,Zebrafish","booktitle":"","editor":"","abstract":"The data presented in this report strongly suggest that the genome of the zebrafish, Brachydanio rerio, has a homeobox cluster which is equivalent to the murine Hox-2 locus. In support of this conclusion, we have found two closely linked zebrafish genes which are true homologues of the mouse Hox-2.1 and Hox-2.2 genes. Here we describe structural and functional properties of the zebrafish Hox-2.2 homologue hox-2.2. Furthermore, we have identified another zebrafish gene related to hox-2.2 which appears to correspond to the Hox-6.1 gene of the murine Hox-3 locus. In order to characterize the zebrafish hox-2.2 gene we have determined the genomic DNA sequence of a 3.4 kb SalI fragment. This revealed that the hox-2.2 transcription unit encodes a putative protein of 228 amino acids. The homeodomains of the murine Hox-2.2 and the zebrafish hox-2.2 proteins are almost identical and extensive sequence identity exists in other regions of the two proteins, which share 160 (70%) of the amino acid residues. Also in terms of expression, strong similarities were observed relative to the murine Hox-2.2 gene. Transcripts derived from zebrafish hox-2.2 start to accumulate when somite formation is initiated. Later in development these transcripts are detected mainly in the central nervous system. Reminiscent of Hox-2.2, the rostral boundary of zebrafish hox-2.2 expression is located in the posterior region of the hindbrain. Notably, untranslated regions of the hox-2.2 gene contain several short sequences closely related to a known homeodomain recognition sequence.","address":"","school":"","issn":"0261-4189","doi":"","isi":"","pubmed":"1968004","key":"Nj\u00f8lstad1990","howpublished":"","urllink":"","refid":53}
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{userid:"molven", "articletype":"article","pages":"9097-9111","author":"P R Nj\u00f8lstad, A Molven, I Hordvik, J Apold, A Fjose","year":"1988","title":"Primary structure, developmentally regulated expression and potential duplication of the zebrafish homeobox gene ZF-21.","month":"Oct","journal":"Nucleic Acids Res","publisher":"","volume":"16","number":"19","note":"","tags":"Amino Acid Sequence,Animals,Base Sequence,Blotting, Northern,Cloning, Molecular,DNA,Fishes,Gene Expression Regulation,Genes, Homeobox,Molecular Sequence Data,Multigene Family,RNA, Messenger,Restriction Mapping","booktitle":"","editor":"","abstract":"We report the molecular cloning and characterization of a cDNA derived from a zebrafish gene (ZF-21) related to the mouse homeobox containing gene Hox2.1. Interesting information about the differential conservation of various domains was gained from comparisons between the putative protein sequences from ZF-21 (275 amino acids) and Hox2.1 (279 aa). A separate DNA binding domain including the ZF-21 homeodomain and 36 additional flanking residues is completely identical to the C-terminal part of Hox2.1. As a consequence, these two mouse and zebrafish proteins must have identical DNA binding properties. A lower level of sequence identity between the N-terminal coding regions of ZF-21 and Hox2.1 reduces the total protein homology to 81%. However, short stretches of perfect homology in these N-terminals suggests that the essential biochemical functions are the same. As expected for true homologues, the ZF-21 and Hox2.1 genes also share extensive similarities with respect to non-coding sequences and temporal expression during embryogenesis. The finding of a potential ZF-21 duplication is discussed in relation to functional and evolutionary aspects of vertebrate homeobox genes.","address":"","school":"","issn":"0305-1048","doi":"","isi":"","pubmed":"2902580","key":"Nj\u00f8lstad1988","howpublished":"","urllink":"","refid":55}
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