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{userid:"fmbuonaguro", "articletype":"article","pages":"","author":"Antonella Borrelli, Anna Lucia Tornesello, Maria Lina Tornesello, Franco M Buonaguro","year":"2018","title":"Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents.","month":"Jan","journal":"Molecules (Basel, Switzerland)","publisher":"","volume":"23","number":"2","note":"","tags":"","booktitle":"","editor":"","abstract":"Cell membranes with their selective permeability play important functions in the tight control of molecular exchanges between the cytosol and the extracellular environment as the intracellular membranes do within the internal compartments. For this reason the plasma membranes often represent a challenging obstacle to the intracellular delivery of many anti-cancer molecules. The active transport of drugs through such barrier often requires specific carriers able to cross the lipid bilayer. Cell penetrating peptides (CPPs) are generally 5-30 amino acids long which, for their ability to cross cell membranes, are widely used to deliver proteins, plasmid DNA, RNA, oligonucleotides, liposomes and anti-cancer drugs inside the cells. In this review, we describe the several types of CPPs, the chemical modifications to improve their cellular uptake, the different mechanisms to cross cell membranes and their biological properties upon conjugation with specific molecules. Special emphasis has been given to those with promising application in cancer therapy.","address":"","school":"","issn":"1420-3049","doi":"10.3390\/molecules23020295","isi":"","pubmed":"29385037","key":"Borrelli2018","howpublished":"","urllink":"","refid":167,"weight":167}
,

{userid:"j.a.diaz-perez", "refid":"334","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"A review of bubble hair deformity.","year":"2023","author":"Yumeng M Li, Julio A Diaz-Perez, Aderonke Obayomi, Fabrizio Galimberti, Paolo Romanelli, Antonella Tosti","journal":"International journal of dermatology","volume":"62","number":"3","pages":"428-431","month":"Mar","doi":"10.1111\/ijd.16200","pubmed":"35486091","pdflink":"","urllink":"","abstract":"Bubble hair deformity is an acquired abnormality characterized by air-filled cavity formations within the hair shaft, usually because of heat damage. Traditionally, bubble hair is diagnosed by visualization of characteristic bubbles under light microscopy. The increased utilization of trichoscopy (scalp dermoscopy) has led to its adoption in the diagnosis of many hair and scalp conditions, including bubble hair deformity. We sought to review clinical reports evaluating the patient profile, use of diagnostic imaging, and treatment options for bubble hair deformity. A systematic search of PubMed was performed in February 2021 using various keywords. Titles and abstracts were screened, leading to the selection of 11 case reports or series. The majority of patients were middle-aged Caucasian women who had used a heated tool to dry or style wet hair. Treatment consisted of cessation of heated tool usage. Light microscopy visualization of characteristic hair shaft cavities was used for diagnosis of bubble hair deformity in reports published prior to 2012. Diagnosis by trichoscopy was used in more recent reports. Our findings support the use of trichoscopy as a convenient and noninvasive method of diagnosing bubble hair deformity. More clinical studies are needed to evaluate the development of bubble hair deformity in ethnic hair.","note":"","tags":"Middle Aged,Humans,Female,Dermoscopy,Hair Diseases,Hair,Scalp,Hot Temperature","weight":334,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1365-4632","isi":"","key":"Li2023","howpublished":""}
,

{userid:"enzo.grossi51", "refid":"369","repocollections":"","attachment":"","_thumb":"","articletype":"misc","sectionheading":"Contributi a Congressi Internazionali \/ Contributes to International Congresses","title":"SEMANTIC CONNECTIVITY MAP OF CLINICAL AND LABORATORY TEST VARIABLES IN PEDIATRIC ACUTE-ONSET NEUROPSYCHIATRIC SYNDROME (PANS)","year":"2019","author":"Antonella Gagliano, C Galati, M Ingrassia, M Ciuffo, G Calabrese, M A Alquino, M Span\u00f2, L Scrofani, A Zuddas, Enzo Grossi ","howpublished":"ESCAP Congress Vienna, 30 june-2 july","doi":"","pubmed":"","pdflink":"","urllink":"https:\/\/www.escap.eu\/escap-congresses\/2019-vienna\/","abstract":"Paediatric acute onset neuropsychiatric syndrome (PANS) is a clinically heterogeneous disorder presenting with abrupt onset of obsessive compulsive disorder or severe eating restrictions and concomitant cognitive, behavioural, or affective symptoms. Different aetiologies and pathogenetic factors of the disorder have been proposed, included specific autoimmune mechanisms. \r\nThe present study describes a clinical sample of 40 children (M26\/F13, mean age 11.1; SD=3.5) diagnosed with PANS. The clinical data were analysed with a fourth-generation artificial neural network: the Auto-CM system, which is able to identify consistent trends and associations among variables, creating a semantic connectivity map. The matrix of connections, takes into account nonlinear associations among variables and captures connection schemes among clusters. \r\nIn our map a close link between the main PANS symptomatic dimensions (anxiety, obsessive-compulsive symptoms, irritability, sleep deterioration and restricted food intake) was observed. A very strong relation between the Natural Killer cell number and the symptoms severity was also found. Moreover, a significant reduction of the peripheral blood Natural Killer cells (NK) counting among the lymphocyte subsets was measured in almost all the children of the sample. On the contrary, a relatively weak connection between symptoms and other laboratory variables such as Antistreptolysin-O (ASO), Antinuclear Antibodies (ANA) and other inflammatory markers aroused from semantic map. \r\nThe semantic map may provide a valid support for identifying the significant clinical characteristics of the disorder and better defining the boundaries of PANS diagnostic construct. ","note":"","tags":"","weight":369}
,

{userid:"vale_nena", "refid":101,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Statistical Classification for Raman Spectra of Tumoral Genomic DNA","year":"2022","author":"Claudio Durastanti, Emilio N. M. Cirillo, Ilaria De Benedictis, Mario Ledda, Antonio Sciortino, Antonella Lisi, Annalisa Convertino, Valentina Mussi","journal":"Micromachines","volume":"13","number":"","pages":"1388","month":"","doi":"10.3390\/mi13091388","pubmed":"","pdflink":"file:\/\/\/D:\/Downloads\/micromachines-13-01388.pdf","urllink":"","abstract":"We exploit Surface-Enhanced Raman Scattering (SERS) to investigate aqueous droplets\r\nof genomic DNA deposited onto silver-coated silicon nanowires, and we show that it is possible to\r\nefficiently discriminate between spectra of tumoral and healthy cells. To assess the robustness of\r\nthe proposed technique, we develop two different statistical approaches, one based on the Principal\r\nComponents Analysis of spectral data and one based on the computation of the `2 distance between\r\nspectra. Both methods prove to be highly efficient, and we test their accuracy via the Cohen\u2019s \u03ba statis-\r\ntics. We show that the synergistic combination of the SERS spectroscopy and the statistical analysis\r\nmethods leads to efficient and fast cancer diagnostic applications allowing rapid and unexpansive\r\ndiscrimination between healthy and tumoral genomic DNA alternative to the more complex and\r\nexpensive DNA sequencing","note":"","tags":"tumoral genomic DNA; Raman spectroscopy; classification; principal component analysis; logistic regression; minimum distance classifiers","weight":101}
,

{userid:"enzo.grossi", "refid":"609","repocollections":"","attachment":"","_thumb":"","articletype":"misc","sectionheading":"Conference papers","title":"SEMANTIC CONNECTIVITY MAP OF CLINICAL AND LABORATORY TEST VARIABLES IN PEDIATRIC ACUTE-ONSET NEUROPSYCHIATRIC SYNDROME (PANS)","year":"2019","author":"Antonella  Gagliano, C. Galati, M. Ingrassia, M. Ciuffo, G. Calabrese, M.A. Alquino, M. Span\u00f2, L. Scrofani, A. Zuddas and Enzo Grossi","howpublished":"ESCAP CONGRESS VIENNA JULY 2019","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"Paediatric acute onset neuropsychiatric syndrome (PANS) is a clinically heterogeneous disorder  presenting with abrupt onset of obsessive compulsive disorder or severe eating restrictions and concomitant cognitive, behavioural, or affective symptoms. Different aetiologies and pathogenetic factors of the disorder have been proposed, included specific autoimmune mechanisms.  \r\nThe present study describes a clinical sample of 40 children (M26\/F13, mean age 11.1; SD=3.5) diagnosed with PANS. The clinical data were analysed with a fourth-generation artificial neural network: the Auto-CM system, which is able to identify consistent trends and associations among variables, creating  a semantic connectivity map. The matrix of connections, takes into account nonlinear associations among variables and captures connection schemes among clusters. \r\nIn our map a close link between the main PANS symptomatic dimensions (anxiety, obsessive-compulsive  symptoms, irritability, sleep deterioration and restricted food intake) was observed. A very strong  relation between the Natural Killer cell number and the symptoms severity was also found. Moreover, a significant reduction of the peripheral blood Natural Killer cells (NK) counting among the lymphocyte subsets was measured in almost all the children of the sample. On the contrary, a relatively weak connection between symptoms and  other laboratory variables such as Antistreptolysin-O (ASO), Antinuclear Antibodies (ANA) and other inflammatory markers aroused from semantic map. \r\nThe semantic map may provide a valid support for identifying the significant clinical characteristics of the disorder and better defining  the boundaries of PANS diagnostic construct.\r\n","note":"","tags":"","weight":609}
,

{userid:"andrea.genre", "articletype":"article","pages":"1926-1937","author":"Rita S L Veiga, Antonella Faccio, Andrea Genre, Corn\u00e9 M J Pieterse, Paola Bonfante, Marcel G A van der Heijden","year":"2013","title":"Arbuscular mycorrhizal fungi reduce growth and infect roots of the non-host plant Arabidopsis thaliana.","month":"Nov","journal":"Plant, cell & environment","publisher":"","volume":"36","number":"11","note":"","tags":"Arabidopsis,Biomass,Colony Count, Microbial,Genotype,Lolium,Mycorrhizae,Nitrogen,Phosphorus,Trifolium","booktitle":"","editor":"","abstract":"The arbuscular mycorrhizal (AM) symbiosis is widespread throughout the plant kingdom and important for plant nutrition and ecosystem functioning. Nonetheless, most terrestrial ecosystems also contain a considerable number of non-mycorrhizal plants. The interaction of such non-host plants with AM fungi (AMF) is still poorly understood. Here, in three complementary experiments, we investigated whether the non-mycorrhizal plant Arabidopsis thaliana, the model organism for plant molecular biology and genetics, interacts with AMF. We grew A.\u2009thaliana alone or together with a mycorrhizal host species (either Trifolium pratense or Lolium multiflorum) in the presence or absence of the AMF\u2005Rhizophagus irregularis. Plants were grown in a dual-compartment system with a hyphal mesh separating roots of A.\u2009thaliana from roots of the host species, avoiding direct root competition. The host plants in the system ensured the presence of an active AM fungal network. AM fungal networks caused growth depressions in A.\u2009thaliana of more than 50% which were not observed in the absence of host plants. Microscopy analyses revealed that R.\u2009irregularis supported by a host plant was capable of infecting A.\u2009thaliana root tissues (up to 43% of root length colonized), but no arbuscules were observed. The results reveal high susceptibility of A.\u2009thaliana to R.\u2009irregularis, suggesting that A.\u2009thaliana is a suitable model plant to study non-host\/AMF interactions and the biological basis of AM incompatibility.","address":"","school":"","issn":"1365-3040","doi":"10.1111\/pce.12102","isi":"","pubmed":"23527688","key":"Veiga2013","howpublished":"","urllink":"","refid":40,"weight":40}
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{userid:"vale_nena", "refid":107,"repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Learning models for classifying Raman spectra of genomic DNA from tumor subtypes","year":"2023","author":"Giacomo Lancia, Claudio Durastanti, Cristian Spitoni, Ilaria De Benedictis, Antonio Sciortino, Emilio N. M. Cirillo, Mario Ledda, Antonella Lisi, Annalisa Convertino & Valentina Mussi","journal":"Scientific Reports","volume":"13","number":"","pages":"11370","month":"","doi":"10.1038\/s41598-023-37303-w","pubmed":"","pdflink":"","urllink":"","abstract":"An early and accurate detection of different subtypes of tumors is crucial for an effective guidance to\r\npersonalized therapy and in predicting the ability of tumor to metastasize. Here we exploit the Surface\r\nEnhanced Raman Scattering (SERS) platform, based on disordered silver coated silicon nanowires (Ag\/\r\nSiNWs), to efficiently discriminate genomic DNA of different subtypes of melanoma and colon tumors.\r\nThe diagnostic information is obtained by performing label free Raman maps of the dried drops of\r\nDNA solutions onto the Ag\/NWs mat and leveraging the classification ability of learning models to\r\nreveal the specific and distinct physico-chemical interaction of tumor DNA molecules with the Ag\/NW,\r\nhere supposed to be partly caused by a different DNA methylation degree.","note":"","tags":"","weight":107}
,

{userid:"flavia.longo", "articletype":"article","pages":"","author":"Elisa Giannetta, Andrea M Isidori, Cosimo Durante, Cira Di Gioia, Flavia Longo, Vincenzo Tombolini, Nadia Bulzonetti, Chiara Graziadio, Riccardo Pofi, Daniele Gianfrilli, Antonella Verrienti, Raffaella Carletti, Sebastiano Filetti, Andrea Lenzi, Alberto Baroli","year":"2017","title":"Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET\/CT: A case report.","month":"Feb","journal":"Medicine","publisher":"","volume":"96","number":"6","note":"","tags":"Aged,Antineoplastic Combined Chemotherapy Protocols,Antiviral Agents,Female,Fluorodeoxyglucose F18,Foscarnet,Humans,Positron Emission Tomography Computed Tomography,Thyroid Carcinoma, Anaplastic,Thyroid Neoplasms","booktitle":"","editor":"","abstract":"The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).","address":"","school":"","issn":"1536-5964","doi":"10.1097\/MD.0000000000005621","isi":"","pubmed":"28178124","key":"Giannetta2017","howpublished":"","urllink":"","refid":99,"weight":99}
,

{userid:"tassone", "articletype":"article","pages":"26-35","author":"Pierpaolo Correale, Cirino Botta, Maria S Rotundo, Annamaria Guglielmo, Raffaele Conca, Antonella Licchetta, Pierpaolo Pastina, Elena Bestoso, Domenico Ciliberto, Maria G Cusi, Antonella Fioravanti, Giacomo M Guidelli, Maria T Bianco, Gabriella Misso, Elodia Martino, Michele Caraglia, Pierfrancesco Tassone, Enrico Mini, Giovanni Mantovani, Ruggero Ridolfi, Luigi Pirtoli, Pierosandro Tagliaferri","year":"2014","title":"Gemcitabine, oxaliplatin, levofolinate, 5-fluorouracil, granulocyte-macrophage colony-stimulating factor, and interleukin-2 (GOLFIG) versus FOLFOX chemotherapy in metastatic colorectal cancer patients: the GOLFIG-2 multicentric open-label randomized phase III trial.","month":"Jan","journal":"Journal of immunotherapy (Hagerstown, Md. : 1997)","publisher":"","volume":"37","number":"1","note":"","tags":"Adult,Aged,Aged, 80 and over,Antineoplastic Combined Chemotherapy Protocols,Colorectal Neoplasms,Deoxycytidine,Female,Fluorouracil,Granulocyte-Macrophage Colony-Stimulating Factor,Humans,Interleukin-2,Leucovorin,Lymphocytes, Tumor-Infiltrating,Male,Middle Aged,Neoplasm Grading,Neoplasm Metastasis,Organoplatinum Compounds,Treatment Outcome","booktitle":"","editor":"","abstract":"The GOLFIG-2 phase III trial was designed to compare the immunobiological activity and antitumor efficacy of GOLFIG chemoimmunotherapy regimen with standard FOLFOX-4 chemotherapy in frontline treatment of metastatic colorectal cancer (mCRC) patients. This trial was conceived on the basis of previous evidence of antitumor and immunomodulating activity of the GOLFIG regimen in mCRC. GOLFIG-2 is a multicentric open\/label phase III trial (EUDRACT: 2005-003458-81). Chemo-naive mCRC patients were randomized in a 1:1 ratio to receive biweekly standard FOLFOX-4 or GOLFIG [gemcitabine (1000 mg\/m(2), day 1); oxaliplatin (85 mg\/m(2), day 2); levofolinate (100 mg\/m(2), days 1-2), 5-fluorouracil (5-FU) (400 mg\/m(2) in bolus followed by 24 h infusion at 800 mg\/m(2),days 1-2), sc. GM-CSF (100 \u03bcg, days 3-7); sc. aldesleukin (0\u00b75 MIU bi-daily, days 8-14 and 17-30)] treatments. The study underwent early termination because of poor recruitment in the control arm. After a median follow-up of 43.83 months, GOLFIG regimen showed superiority over FOLFOX in terms of progression-free survival [median 9\u00b723 (95% confidence interval (CI), 6\u00b79-11.5) vs. median 5.70 (95% CI, 3.38-8.02) months; hazard ratio (HR): 0.52 (95% CI, 0.35-0.77), P=0\u00b7002] and response rate [66.1% (95% CI, 0.41-0.73) vs. 37\u00b70% (95% CI, 0.28-0.59), P=0.002], with a trend to longer survival [median 21.63 (95% CI, 18.09-25.18) vs. 14.57 mo (95% CI, 9.07-20.07); HR: 0\u00b779 (95% CI, 0.52-1.21); P=0.28]. Patients in the experimental arm showed higher incidence of non-neutropenic fever (18.5%), autoimmunity signs (18.5%), an increase in the number of monocytes, eosinophils, CD4(+) T lymphocytes, natural killer cells, and a decrease in immunoregulatory (CD3(+)CD4(+)CD25(+)FoxP3(+)) T cells. Taken together, these findings provide proof-of-principle that GOLFIG chemoimmunotherapy may represent a novel reliable option for first-line treatment of mCRC.","address":"","school":"","issn":"1537-4513","doi":"10.1097\/CJI.0000000000000004","isi":"","pubmed":"24316553","key":"Correale2014","howpublished":"","urllink":"","refid":142,"weight":142}
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{userid:"srchamb", "articletype":"article","pages":"501-509","author":"Samuel R Chamberlain, Karin Mogg, Brendan P Bradley, Annelize Koch, Chris M Dodds, Wenli X Tao, Kay Maltby, Bhopinder Sarai, Antonella Napolitano, Duncan B Richards, Edward T Bullmore, Pradeep J Nathan","year":"2012","title":"Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals.","month":"Dec","journal":"Psychopharmacology","publisher":"","volume":"224","number":"4","note":"","tags":"Adolescent,Adult,Attention,Binge-Eating Disorder,Cognition,Dose-Response Relationship, Drug,Double-Blind Method,Female,Humans,Indans,Male,Middle Aged,Narcotic Antagonists,Neuropsychological Tests,Receptors, Opioid, mu,Severity of Illness Index,Time Factors,Triazoles,Young Adult","booktitle":"","editor":"","abstract":"Translational research implicates the mu opioid neurochemical system in hedonic processing, but its role in dissociable high-level cognitive functions is not well understood. Binge-eating represents a useful model of 'behavioural addiction' for exploring this issue.","address":"","school":"","issn":"1432-2072","doi":"10.1007\/s00213-012-2778-x","isi":"","pubmed":"22752384","key":"Chamberlain2012","howpublished":"","urllink":"","refid":69}
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