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{userid:"publist_brainimaging", "articletype":"article","pages":"648-652","author":"M Merickel, R Gray, P Chauvin, S Appel","year":"1981","title":"Cultured muscle from myotonic muscular dystrophy patients: altered membrane electrical properties.","month":"Jan","journal":"Proceedings of the National Academy of Sciences of the United States of America","publisher":"","volume":"78","number":"1","note":"","tags":"Action Potentials,Biopsy,Culture Techniques,Humans,Membrane Potentials,Muscles,Muscular Dystrophies,Potassium","booktitle":"","editor":"","abstract":"Myotonic muscular dystrophy (MyD) is an inherited human disease involving skeletal muscle as well as many other organ systems. We have approached the study of this disorder by growing normal and diseased human muscle in a primary tissue culture system and investigating some of the electrical properties of the resulting myotubes. The most distinctive abnormality noted in MyD myotubes was an increased tendency to fire repetitive action potentials. A decreased action potential afterhyperpolarization amplitude and the presence of depolarizing afterpotentials were also noted, as were a decreased resting membrane potential, decreased action potential amplitude and overshoot, and decreased outward-going rectification. Although the ionic basis of these abnormal properties in vitro is not clearly defined, changes in the slow outward-going potassium current offer the best explanation. Furthermore, MyD cell culture offers a valuable model for critical analysis of the molecular mechanisms underlying MyD deficits.","address":"","school":"","issn":"0027-8424","doi":"","isi":"","pubmed":"6941262","key":"Merickel1981","howpublished":"","urllink":"","refid":73,"weight":73}
,

{userid:"mmckeown", "refid":"235","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Altered EEG alpha and theta oscillations characterize apathy in Parkinson's disease during incentivized movement \r\n","year":"2019","author":"M Zhu, A HajiHosseini, TR Baumeister, S Garg,  S Appel-Cresswell, MJ McKeown\r\n","journal":"NeuroImage: Clinical","volume":"23","number":"101922","pages":"","month":"Jul","doi":"10.1016\/j.nicl.2019.101922","pubmed":"31284232","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":235}
,

{userid:"mmckeown", "refid":"298","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Apathy scores in Parkinson\u2019s disease relate to EEG components in an incentivized motor task","year":"2024","author":"S. Lee, E. Song, M Zhu, S Appel-Cresswell, and MJ McKeown","journal":"Brain Communications","volume":"6","number":"1","pages":"fcae025","month":"","doi":"","pubmed":"","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":298}
,

{userid:"christian.ulrichs", "articletype":"article","pages":"2450-2462","author":"I Mewis, J G Tokuhisa, J C Schultz, H M Appel, C Ulrichs, J Gershenzon","year":"2006","title":"Gene expression and glucosinolate accumulation in Arabidopsis thaliana in response to generalist and specialist herbivores of different feeding guilds and the role of defense signaling pathways","month":"","journal":"PHYTOCHEMISTRY","publisher":"","volume":"67","number":"22","note":"Times Cited: 36","tags":"","booktitle":"","editor":"","abstract":"Glucosinolate accumulation and expression of glucosinolate biosynthetic genes were studied in response to four herbivores in Arabidopsis thaliana (L.) wild-type (Columbia) and mutant lines affected in defense signaling. Herbivory on wild-type plants led to increased aliphatic glucosinolate content for three of four herbivores tested, the aphid generalist Myzus persicae (Sulzer), the aphid specialist Brevicoryne brassicae (L.), and the lepidopteran generalist Spodoptera exigua Hubner. The lepidopteran specialist Pieris rapae L. did not alter aliphatic glucosinolate content in the wild-type, but indole glucosinolates increased slightly. Gene expression associated with aliphatic glucosinolate biosynthesis increased after feeding by all species, indicating that glucosinolate accumulation is not always regulated at the level of these gene transcripts. A. thaliana lines with mutations in jasmonate (coil), salicylate (npr1), and ethylene signaling (etr1) diverged in gene expression, glucosinolate content, and insect performance compared to wild-type suggesting the involvement of all three modes of signaling in responses to herbivores. The coil mutant had much lower constitutive levels of aliphatic glucosinolates than wildtype but content increased in response to herbivory. In contrast, nprl had higher constitutive levels of aliphatic glucosinolates and levels did not increase after feeding. Glucosinolate content of the etr1 mutant was comparable to wild-type and did not change with herbivory, except for P. rapae feeding which elicited elevated indolyl glucosinolate levels. Unlike the wild-type response, gene transcripts of aliphatic glucosinolate biosynthesis did not generally increase in the mutants. Both glucosinolate content and gene expression data indicate that salicylate and ethylene signaling repress some jasmonate-mediated responses to herbivory. (c) 2006 Elsevier Ltd. All rights reserved.","address":"","school":"","issn":"0031-9422","doi":"10.1016\/j.phytochem.2006.09.004","isi":"WOS:000242261700005","pubmed":"","key":"Mewis2006","howpublished":"","urllink":"","refid":32}
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{userid:"christian.ulrichs", "articletype":"article","pages":"2450-2462","author":"Inga Mewis, James G Tokuhisa, Jack C Schultz, Heidi M Appel, Christian Ulrichs, Jonathan Gershenzon","year":"2006","title":"Gene expression and glucosinolate accumulation in Arabidopsis thaliana in response to generalist and specialist herbivores of different feeding guilds and the role of defense signaling pathways.","month":"Nov","journal":"Phytochemistry","publisher":"","volume":"67","number":"22","note":"","tags":"Animals,Aphids,Arabidopsis,Colombia,Feeding Behavior,Gene Expression,Glucosinolates,Lepidoptera,Mutation,Signal Transduction","booktitle":"","editor":"","abstract":"Glucosinolate accumulation and expression of glucosinolate biosynthetic genes were studied in response to four herbivores in Arabidopsis thaliana (L.) wild-type (Columbia) and mutant lines affected in defense signaling. Herbivory on wild-type plants led to increased aliphatic glucosinolate content for three of four herbivores tested, the aphid generalist Myzus persicae (Sulzer), the aphid specialist Brevicoryne brassicae (L.), and the lepidopteran generalist Spodoptera exigua H\u00fcbner. The lepidopteran specialist Pieris rapae L. did not alter aliphatic glucosinolate content in the wild-type, but indole glucosinolates increased slightly. Gene expression associated with aliphatic glucosinolate biosynthesis increased after feeding by all species, indicating that glucosinolate accumulation is not always regulated at the level of these gene transcripts. A. thaliana lines with mutations in jasmonate (coi1), salicylate (npr1), and ethylene signaling (etr1) diverged in gene expression, glucosinolate content, and insect performance compared to wild-type suggesting the involvement of all three modes of signaling in responses to herbivores. The coi1 mutant had much lower constitutive levels of aliphatic glucosinolates than wild-type but content increased in response to herbivory. In contrast, npr1 had higher constitutive levels of aliphatic glucosinolates and levels did not increase after feeding. Glucosinolate content of the etr1 mutant was comparable to wild-type and did not change with herbivory, except for P. rapae feeding which elicited elevated indolyl glucosinolate levels. Unlike the wild-type response, gene transcripts of aliphatic glucosinolate biosynthesis did not generally increase in the mutants. Both glucosinolate content and gene expression data indicate that salicylate and ethylene signaling repress some jasmonate-mediated responses to herbivory.","address":"","school":"","issn":"0031-9422","doi":"10.1016\/j.phytochem.2006.09.004","isi":"","pubmed":"17049571","key":"Mewis2006","howpublished":"","urllink":"","refid":60}
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{userid:"anthony.sebastian", "articletype":"article","pages":"497-504","author":"Kendall F Moseley, Connie M Weaver, Lawrence Appel, Anthony Sebastian, Deborah E Sellmeyer","year":"2013","title":"Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women.","month":"Mar","journal":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","publisher":"","volume":"28","number":"3","note":"","tags":"Aged,Bone and Bones,Calcium,Female,Humans,Male,Middle Aged,Placebos,Potassium Citrate","booktitle":"","editor":"","abstract":"The dietary acid load created by the typical Western diet may adversely impact the skeleton by disrupting calcium metabolism. Whether neutralizing dietary acid with alkaline potassium salts results in sustained improvements in calcium balance remains controversial. In this randomized, double-blind, placebo-controlled study, 52 men and women (mean age 65.2\u2009\u00b1\u20096.2 years) were randomly assigned to potassium citrate 60\u2009mmol\/d, 90\u2009mmol\/d, or placebo daily with measurements of bone turnover markers, net acid excretion, and calcium metabolism, including intestinal fractional calcium absorption and calcium balance, obtained at baseline and at 6 months. At 6 months, net acid excretion was significantly lower in both treatment groups compared to placebo and it was negative, meaning subjects' dietary acid was completely neutralized (-11.3\u2009mmol\/d on 60\u2009mmol\/d; -29.5\u2009mmol\/d on 90\u2009mmol\/d, p\u2009<\u20090.001 compared to placebo). At 6 months, 24-hour urine calcium was significantly reduced in persons taking potassium citrate 60\u2009mmol\/d (-46\u2009\u00b1\u200915.9\u2009mg\/d) and 90\u2009mmol\/d (-59\u2009\u00b1\u200931.6\u2009mg\/d) compared with placebo (p\u2009<\u20090.01). Fractional calcium absorption was not changed by potassium citrate supplementation. Net calcium balance was significantly improved in participants taking potassium citrate 90\u2009mmol\/d compared to placebo (142\u2009\u00b1\u200980\u2009mg\/d on 90\u2009mmol\/d versus -80\u2009\u00b1\u200954\u2009mg\/d on placebo; p\u2009=\u20090.02). Calcium balance was also improved on potassium citrate 60\u2009mmol\/d, but this did not reach statistical significance (p\u2009=\u20090.18). Serum C-telopeptide decreased significantly in both potassium citrate groups compared to placebo (-34.6\u2009\u00b1\u200939.1\u2009ng\/L on 90\u2009mmol\/d, p\u2009=\u20090.05; -71.6\u2009\u00b1\u200940.7\u2009ng\/L on 60\u2009mmol\/d, p\u2009=\u20090.02) whereas bone-specific alkaline phosphatase did not change. Intact parathyroid hormone was significantly decreased in the 90\u2009mmol\/d group (p\u2009=\u20090.01). Readily available, safe, and easily administered in an oral form, potassium citrate has the potential to improve skeletal health. Longer-term trials with definitive outcomes such as bone density and fracture are needed.","address":"","school":"","issn":"1523-4681","doi":"10.1002\/jbmr.1764","isi":"","pubmed":"22991267","key":"Moseley2013","howpublished":"","urllink":"","refid":12,"weight":12}
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{userid:"mmckeown", "refid":"222","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Habitual exercisers versus sedentary subjects with Parkinson's Disease: Multimodal PET and fMRI study","year":"2018","author":"MA. Sacheli, DK Murray, N Vafai, K Dinelle, N Neilson, J McKenzie, S Appel-Cresswell, MJ McKeown, M Schulzer, V Sossi, A J Stoessl","journal":"Movement Disorders","volume":"33","number":"12","pages":"1945-1950","month":"Oct","doi":"https:\/\/doi.org\/10.1002\/mds.27498","pubmed":" 30376184","pdflink":"","urllink":"","abstract":"","note":"","tags":"","weight":222}
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{userid:"ellen-moran", "articletype":"article","pages":"","author":"Ellen M Moran, Ren\u00e9 Heydrich, Chin Teck Ng, Tajvur P Saber, Jennifer McCormick, Joachim Sieper, Heiner Appel, Ursula Fearon, Douglas J Veale","year":"2011","title":"IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates.","month":"08","journal":"PloS one","publisher":"","volume":"6","number":"8","note":"","tags":"Anoxia,Arthritis,Cell Movement,Humans,Inflammation,Interleukin-17,Joints,Leukocytes, Mononuclear,Neutrophils,Synovial Fluid,Synovial Membrane","booktitle":"","editor":"","abstract":"This study examines the expression of IL-17A-secreting cells within the inflamed synovium and the relationship to in vivo joint hypoxia measurements.","address":"","school":"","issn":"1932-6203","doi":"10.1371\/journal.pone.0024048","isi":"","pubmed":"21887369","key":"Moran2011","howpublished":"","urllink":"","refid":3,"weight":3}
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{userid:"j.l.medina-franco", "refid":"41","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Strategies for the use of mixture-based synthetic combinatorial libraries : Scaffold ranking, direct testing, in vivo, and enhanced deconvolution by computational methods","year":"2008","author":"Richard A Houghten, Clernencia Pinilla, Marc A Giulianotti, Jon R Appel, Colette T Dooley, Adel Nefzi, John M Ostresh, Yongping Yu, Gerald M Maggiora, Jose L Medina-Franco, Daniela Brunner, Jeff Schneider","journal":"JOURNAL OF COMBINATORIAL CHEMISTRY","volume":"10","number":"1","pages":"3-19","month":"JAN","doi":"10.1021\/cc7001205","pubmed":"18067268","pdflink":"","urllink":"","abstract":"","note":"","tags":"","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1520-4766","isi":"WOS:000252409800002","key":"Houghten2008","howpublished":""}
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{userid:"r.j.warburton",  _fulltext:1,  _thumb:'_thumb.png', "refid":"622","repocollections":"","attachment":"ref-622\/Riedel_PRApplied_2014.pdf","_thumb":"_thumb.png","articletype":"article","sectionheading":"","title":"Low-Loss Broadband Antenna for Efficient Photon Collection from a Coherent Spin in Diamond","year":"2014","author":"D Riedel, D Rohner, M Ganzhorn, T Kaldewey, P Appel, E Neu, R J Warburton, P Maletinsky","journal":"Physical Review Applied","volume":"2","number":"","pages":"064011","month":"12","doi":"10.1103\/PhysRevApplied.2.064011","pubmed":"","pdflink":"","urllink":"","abstract":"We report the creation of a low-loss broadband optical antenna giving highly directed output from a coherent single spin in the solid state. The device, a crystalline solid-state realization of a dielectric antenna, is engineered for individual nitrogen-vacancy electronic spins in diamond. We demonstrate a directionality close to 10. The photonic structure preserves the high spin coherence of single-crystal diamond (T2\u2273100\u2009\u2009\u03bcs). The single-photon count rate approaches a megahertz facilitating efficient spin readout. We thus demonstrate a key enabling technology for quantum applications such as high-sensitivity magnetometry and long-distance spin entanglement.","note":"","tags":"","weight":622,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"2331-7019","isi":"","key":"ISI:000347200800002","howpublished":""}
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