// +author:m attreed +author:attreed var _ajax_res = { hits: 4, first: 0, results: [ {userid:"emmanuel.barillot", "refid":"159","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation.","year":"2016","author":"Jennifer C Chow, Constance Ciaudo, Melissa J Fazzari, Nathan Mise, Nicolas Servant, Jacob L Glass, Matthew Attreed, Philip Avner, Anton Wutz, Emmanuel Barillot, John M Greally, Olivier Voinnet, Edith Heard","journal":"Cell","volume":"166","number":"3","pages":"","month":"Jul","doi":"10.1016\/j.cell.2016.07.013","pubmed":"27471971","pdflink":"","urllink":"","abstract":"","note":"","tags":"Chromatin Assembly and Disassembly,Heterochromatin,Long Interspersed Nucleotide Elements,X Chromosome,X Chromosome Inactivation","weight":"159","publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1097-4172","isi":"","key":"Chow2016","howpublished":""} , {userid:"awutz", "refid":"82","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation.","year":"2016","author":"Jennifer C Chow, Constance Ciaudo, Melissa J Fazzari, Nathan Mise, Nicolas Servant, Jacob L Glass, Matthew Attreed, Philip Avner, Anton Wutz, Emmanuel Barillot, John M Greally, Olivier Voinnet, Edith Heard","journal":"Cell","volume":"166","number":"3","pages":"782","month":"","doi":"10.1016\/j.cell.2016.07.013","pubmed":"27471971","pdflink":"","urllink":"","abstract":"","note":"","tags":"Chromatin Assembly and Disassembly,Heterochromatin,Long Interspersed Nucleotide Elements,X Chromosome,X Chromosome Inactivation","weight":82,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1097-4172","isi":"","key":"Chow2016","howpublished":""} , {userid:"emmanuel.barillot", "articletype":"article","pages":"956-969","author":"Jennifer C Chow, Constance Ciaudo, Melissa J Fazzari, Nathan Mise, Nicolas Servant, Jacob L Glass, Matthew Attreed, Philip Avner, Anton Wutz, Emmanuel Barillot, John M Greally, Olivier Voinnet, Edith Heard","year":"2010","title":"LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.","month":"Jun","journal":"Cell","publisher":"","volume":"141","number":"6","note":"","tags":"Animals,Cell Line,Embryonic Stem Cells,Female,Heterochromatin,Humans,Long Interspersed Nucleotide Elements,Mice,RNA, Untranslated,Transcription, Genetic,X Chromosome,X Chromosome Inactivation","booktitle":"","editor":"","abstract":"During X chromosome inactivation (XCI), Xist RNA coats and silences one of the two X chromosomes in female cells. Little is known about how XCI spreads across the chromosome, although LINE-1 elements have been proposed to play a role. Here we show that LINEs participate in creating a silent nuclear compartment into which genes become recruited. A subset of young LINE-1 elements, however, is expressed during XCI, rather than being silenced. We demonstrate that such LINE expression requires the specific heterochromatic state induced by Xist. These LINEs often lie within escape-prone regions of the X chromosome, but close to genes that are subject to XCI, and are associated with putative endo-siRNAs. LINEs may thus facilitate XCI at different levels, with silent LINEs participating in assembly of a heterochromatic nuclear compartment induced by Xist, and active LINEs participating in local propagation of XCI into regions that would otherwise be prone to escape.","address":"","school":"","issn":"1097-4172","doi":"10.1016\/j.cell.2010.04.042","isi":"","pubmed":"20550932","key":"Chow2010","howpublished":"","urllink":"","refid":76} , {userid:"awutz", "articletype":"article","pages":"956-969","author":"Jennifer C Chow, Constance Ciaudo, Melissa J Fazzari, Nathan Mise, Nicolas Servant, Jacob L Glass, Matthew Attreed, Philip Avner, Anton Wutz, Emmanuel Barillot, John M Greally, Olivier Voinnet, Edith Heard","year":"2010","title":"LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.","month":"Jun","journal":"Cell","publisher":"","volume":"141","number":"6","note":"","tags":"Animals,Cell Line,Embryonic Stem Cells,Female,Heterochromatin,Humans,Long Interspersed Nucleotide Elements,Mice,RNA, Long Untranslated,RNA, Untranslated,Transcription, Genetic,X Chromosome,X Chromosome Inactivation","booktitle":"","editor":"","abstract":"During X chromosome inactivation (XCI), Xist RNA coats and silences one of the two X chromosomes in female cells. Little is known about how XCI spreads across the chromosome, although LINE-1 elements have been proposed to play a role. Here we show that LINEs participate in creating a silent nuclear compartment into which genes become recruited. A subset of young LINE-1 elements, however, is expressed during XCI, rather than being silenced. We demonstrate that such LINE expression requires the specific heterochromatic state induced by Xist. These LINEs often lie within escape-prone regions of the X chromosome, but close to genes that are subject to XCI, and are associated with putative endo-siRNAs. LINEs may thus facilitate XCI at different levels, with silent LINEs participating in assembly of a heterochromatic nuclear compartment induced by Xist, and active LINEs participating in local propagation of XCI into regions that would otherwise be prone to escape.","address":"","school":"","issn":"1097-4172","doi":"10.1016\/j.cell.2010.04.042","isi":"","pubmed":"20550932","key":"Chow2010","howpublished":"","urllink":"","refid":36} ] } ; ajaxResultsLoaded(_ajax_res);