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{userid:"katrin.horn", "refid":"22","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.","year":"2021","author":"Mathias Gorski, Bettina Jung, Yong Li, Pamela R Matias-Garcia, Matthias Wuttke, Stefan Coassin, Chris H L Thio, Marcus E Kleber, Thomas W Winkler, Veronika Wanner, Jin-Fang Chai, Audrey Y Chu, Massimiliano Cocca, Mary F Feitosa, Sahar Ghasemi, Anselm Hoppmann, Katrin Horn, Man Li, Teresa Nutile, Markus Scholz, Karsten B Sieber, Alexander Teumer, Adrienne Tin, Judy Wang, Bamidele O Tayo, Tarunveer S Ahluwalia, Peter Almgren, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Robert J Carroll, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Josef Coresh, Martin H de Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Andre Franke, Sandra Freitag-Wolf, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Christian Gieger, Pavel Hamet, Kevin Ho, Edith Hofer, Bernd Holleczek, Valencia Hui Xian Foo, Nina Hutri-K\u00e4h\u00f6nen, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Mika K\u00e4h\u00f6nen, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Kr\u00e4mer, Brigitte K\u00fchnel, Leslie A Lange, Terho Lehtim\u00e4ki, Wolfgang Lieb,  ,  , Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytik\u00e4inen, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Josyf C Mychaleckyj, Girish N Nadkarni, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Michelle L O'Donoghue, Marju Orho-Melander, Sarah A Pendergrass, Brenda W J H Penninx, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Charumathi Sabanayagam, Helena Schmidt, Reinhold Schmidt, Ben Sch\u00f6ttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Konstantin Strauch, Silke Szymczak, Kent D Taylor, Johanne Tremblay, Layal Chaker, Pim van der Harst, Peter J van der Most, Niek Verweij, Uwe V\u00f6lker, Melanie Waldenberger, Lars Wallentin, Dawn M Waterworth, Harvey D White, James G Wilson, Tien-Yin Wong, Mark Woodward, Qiong Yang, Masayuki Yasuda, Laura M Yerges-Armstrong, Yan Zhang, Harold Snieder, Christoph Wanner, Carsten A B\u00f6ger, Anna K\u00f6ttgen, Florian Kronenberg, Cristian Pattaro, Iris M Heid","journal":"Kidney international","volume":"99","number":"4","pages":"926-939","month":"04","doi":"10.1016\/j.kint.2020.09.030","pubmed":"33137338","pdflink":"","urllink":"","abstract":"Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL\/min\/1.73m\/year or more (\"Rapid3\"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL\/min\/1.73m at follow-up among those with eGFRcrea 60 mL\/min\/1.73m or more at baseline (\"CKDi25\"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and\/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and\/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.","note":"","tags":"AMP-Activated Protein Kinases,Creatinine,Genome-Wide Association Study,Glomerular Filtration Rate,Humans,Kidney,Protein Disulfide-Isomerases,United Kingdom","weight":22,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1523-1755","isi":"","key":"Gorski2021","howpublished":""}
,

{userid:"katrin.horn", "refid":"32","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.","year":"2022","author":"Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix G\u00fcnther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan \u00c4rnl\u00f6v, Bj\u00f8rn Olav \u00c5svold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael B\u00f6hnke, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Ben Brumpton, Robert J Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y Chu, Marina Ciullo, Massimiliano Cocca, James P Cook, Josef Coresh, Daniele Cusi, Martin H de Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Michele K Evans, Mary F Feitosa, Andre Franke, Sandra Freitag-Wolf, Christian Fuchsberger, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Christian Gieger, Daniel F Gudbjartsson, Stein Hallan, Pavel Hamet, Asahi Hishida, Kevin Ho, Edith Hofer, Bernd Holleczek, Hilma Holm, Anselm Hoppmann, Katrin Horn, Nina Hutri-K\u00e4h\u00f6nen, Kristian Hveem, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Bettina Jung, Mika K\u00e4h\u00f6nen, Irma Karabegovi\u0107, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Kr\u00e4mer, Brigitte K\u00fchnel, Johanna Kuusisto, Markku Laakso, Leslie A Lange, Terho Lehtim\u00e4ki, Man Li, Wolfgang Lieb,  , Lars Lind, Cecilia M Lindgren, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytik\u00e4inen, Anubha Mahajan, Pamela R Matias-Garcia, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Andrew P Morris, Josyf C Mychaleckyj, Girish N Nadkarni, Mariko Naito, Masahiro Nakatochi, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Teresa Nutile, Michelle L O'Donoghue, Jeffrey O'Connell, Isleifur Olafsson, Marju Orho-Melander, Afshin Parsa, Sarah A Pendergrass, Brenda W J H Penninx, Mario Pirastu, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Myriam Rheinberger, Kenneth M Rice, Federica Rizzi, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Daniela Ruggiero, Kathleen A Ryan, Charumathi Sabanayagam, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Markus Scholz, Ben Sch\u00f6ttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Karsten B Sieber, Xueling Sim, Mario Sims, Harold Snieder, Kira J Stanzick, Unnur Thorsteinsdottir, Hannah Stocker, Konstantin Strauch, Heather M Stringham, Patrick Sulem, Silke Szymczak, Kent D Taylor, Chris H L Thio, Johanne Tremblay, Simona Vaccargiu, Pim van der Harst, Peter J van der Most, Niek Verweij, Uwe V\u00f6lker, Kenji Wakai, Melanie Waldenberger, Lars Wallentin, Stefan Wallner, Judy Wang, Dawn M Waterworth, Harvey D White, Cristen J Willer, Tien-Yin Wong, Mark Woodward, Qiong Yang, Laura M Yerges-Armstrong, Martina Zimmermann, Alan B Zonderman, Tobias Bergler, Kari Stefansson, Carsten A B\u00f6ger, Cristian Pattaro, Anna K\u00f6ttgen, Florian Kronenberg, Iris M Heid","journal":"Kidney international","volume":"102","number":"3","pages":"624-639","month":"Sep","doi":"10.1016\/j.kint.2022.05.021","pubmed":"35716955","pdflink":"","urllink":"","abstract":"Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant-by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with age-dependency of genetic cross-section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in-silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03-1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics.","note":"","tags":"Cross-Sectional Studies,Genetic Loci,Genome-Wide Association Study,Glomerular Filtration Rate,Humans,Kidney,Longitudinal Studies,N-Acetylgalactosaminyltransferases,Renal Insufficiency,Renal Insufficiency, Chronic","weight":32,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1523-1755","isi":"","key":"Gorski2022","howpublished":""}
,

{userid:"katrin.horn", "articletype":"article","pages":"957-972","author":"Matthias Wuttke, Yong Li, Man Li, Karsten B Sieber, Mary F Feitosa, Mathias Gorski, Adrienne Tin, Lihua Wang, Audrey Y Chu, Anselm Hoppmann, Holger Kirsten, Ayush Giri, Jin-Fang Chai, Gardar Sveinbjornsson, Bamidele O Tayo, Teresa Nutile, Christian Fuchsberger, Jonathan Marten, Massimiliano Cocca, Sahar Ghasemi, Yizhe Xu, Katrin Horn, Damia Noce, Peter J van der Most, Sanaz Sedaghat, Zhi Yu, Masato Akiyama, Saima Afaq, Tarunveer S Ahluwalia, Peter Almgren, Najaf Amin, Johan \u00c4rnl\u00f6v, Stephan J L Bakker, Nisha Bansal, Daniela Baptista, Sven Bergmann, Mary L Biggs, Ginevra Biino, Michael Boehnke, Eric Boerwinkle, Mathilde Boissel, Erwin P Bottinger, Thibaud S Boutin, Hermann Brenner, Marco Brumat, Ralph Burkhardt, Adam S Butterworth, Eric Campana, Archie Campbell, Harry Campbell, Micka\u00ebl Canouil, Robert J Carroll, Eulalia Catamo, John C Chambers, Miao-Ling Chee, Miao-Li Chee, Xu Chen, Ching-Yu Cheng, Yurong Cheng, Kaare Christensen, Renata Cifkova, Marina Ciullo, Maria Pina Concas, James P Cook, Josef Coresh, Tanguy Corre, Cinzia Felicita Sala, Daniele Cusi, John Danesh, E Warwick Daw, Martin H de Borst, Alessandro De Grandi, Ren\u00e9e de Mutsert, Aiko P J de Vries, Frauke Degenhardt, Graciela Delgado, Ayse Demirkan, Emanuele Di Angelantonio, Katalin Dittrich, Jasmin Divers, Rajkumar Dorajoo, Kai-Uwe Eckardt, Georg Ehret, Paul Elliott, Karlhans Endlich, Michele K Evans, Janine F Felix, Valencia Hui Xian Foo, Oscar H Franco, Andre Franke, Barry I Freedman, Sandra Freitag-Wolf, Yechiel Friedlander, Philippe Froguel, Ron T Gansevoort, He Gao, Paolo Gasparini, J Michael Gaziano, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Franco Giulianini, Martin G\u00f6gele, Scott D Gordon, Daniel F Gudbjartsson, Vilmundur Gudnason, Toomas Haller, Pavel Hamet, Tamara B Harris, Catharina A Hartman, Caroline Hayward, Jacklyn N Hellwege, Chew-Kiat Heng, Andrew A Hicks, Edith Hofer, Wei Huang, Nina Hutri-K\u00e4h\u00f6nen, Shih-Jen Hwang, M Arfan Ikram, Olafur S Indridason, Erik Ingelsson, Marcus Ising, Vincent W V Jaddoe, Johanna Jakobsdottir, Jost B Jonas, Peter K Joshi, Navya Shilpa Josyula, Bettina Jung, Mika K\u00e4h\u00f6nen, Yoichiro Kamatani, Candace M Kammerer, Masahiro Kanai, Mika Kastarinen, Shona M Kerr, Chiea-Chuen Khor, Wieland Kiess, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Antje K\u00f6rner, Peter Kovacs, Aldi T Kraja, Alena Krajcoviechova, Holly Kramer, Bernhard K Kr\u00e4mer, Florian Kronenberg, Michiaki Kubo, Brigitte K\u00fchnel, Mikko Kuokkanen, Johanna Kuusisto, Martina La Bianca, Markku Laakso, Leslie A Lange, Carl D Langefeld, Jeannette Jen-Mai Lee, Benjamin Lehne, Terho Lehtim\u00e4ki, Wolfgang Lieb,  , Su-Chi Lim, Lars Lind, Cecilia M Lindgren, Jun Liu, Jianjun Liu, Markus Loeffler, Ruth J F Loos, Susanne Lucae, Mary Ann Lukas, Leo-Pekka Lyytik\u00e4inen, Reedik M\u00e4gi, Patrik K E Magnusson, Anubha Mahajan, Nicholas G Martin, Jade Martins, Winfried M\u00e4rz, Deborah Mascalzoni, Koichi Matsuda, Christa Meisinger, Thomas Meitinger, Olle Melander, Andres Metspalu, Evgenia K Mikaelsdottir, Yuri Milaneschi, Kozeta Miliku, Pashupati P Mishra,  , Karen L Mohlke, Nina Mononen, Grant W Montgomery, Dennis O Mook-Kanamori, Josyf C Mychaleckyj, Girish N Nadkarni, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Raymond Noordam, Jeffrey O'Connell, Michelle L O'Donoghue, Isleifur Olafsson, Albertine J Oldehinkel, Marju Orho-Melander, Willem H Ouwehand, Sandosh Padmanabhan, Nicholette D Palmer, Runolfur Palsson, Brenda W J H Penninx, Thomas Perls, Markus Perola, Mario Pirastu, Nicola Pirastu, Giorgio Pistis, Anna I Podgornaia, Ozren Polasek, Belen Ponte, David J Porteous, Tanja Poulain, Peter P Pramstaller, Michael H Preuss, Bram P Prins, Michael A Province, Ton J Rabelink, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Paul M Ridker, Fernando Rivadeneira, Federica Rizzi, David J Roberts, Antonietta Robino, Peter Rossing, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Kathleen A Ryan, Yasaman Saba, Charumathi Sabanayagam, Veikko Salomaa, Erika Salvi, Kai-Uwe Saum, Helena Schmidt, Reinhold Schmidt, Ben Sch\u00f6ttker, Christina-Alexandra Schulz, Nicole Schupf, Christian M Shaffer, Yuan Shi, Albert V Smith, Blair H Smith, Nicole Soranzo, Cassandra N Spracklen, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Per O Svensson, Silke Szymczak, E-Shyong Tai, Salman M Tajuddin, Nicholas Y Q Tan, Kent D Taylor, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H L Thio, Hauke Thomsen, Gudmar Thorleifsson, Daniela Toniolo, Anke T\u00f6njes, Johanne Tremblay, Ioanna Tzoulaki, Andr\u00e9 G Uitterlinden, Simona Vaccargiu, Rob M van Dam, Pim van der Harst, Cornelia M van Duijn, Digna R Velez Edward, Niek Verweij, Suzanne Vogelezang, Uwe V\u00f6lker, Peter Vollenweider, Gerard Waeber, Melanie Waldenberger, Lars Wallentin, Ya Xing Wang, Chaolong Wang, Dawn M Waterworth, Wen Bin Wei, Harvey White, John B Whitfield, Sarah H Wild, James F Wilson, Mary K Wojczynski, Charlene Wong, Tien-Yin Wong, Liang Xu, Qiong Yang, Masayuki Yasuda, Laura M Yerges-Armstrong, Weihua Zhang, Alan B Zonderman, Jerome I Rotter, Murielle Bochud, Bruce M Psaty, Veronique Vitart, James G Wilson, Abbas Dehghan, Afshin Parsa, Daniel I Chasman, Kevin Ho, Andrew P Morris, Olivier Devuyst, Shreeram Akilesh, Sarah A Pendergrass, Xueling Sim, Carsten A B\u00f6ger, Yukinori Okada, Todd L Edwards, Harold Snieder, Kari Stefansson, Adriana M Hung, Iris M Heid, Markus Scholz, Alexander Teumer, Anna K\u00f6ttgen, Cristian Pattaro","year":"2019","title":"A catalog of genetic loci associated with kidney function from analyses of a million individuals.","month":"06","journal":"Nature genetics","publisher":"","volume":"51","number":"6","note":"","tags":"Chromosome Mapping,European Continental Ancestry Group,Genetic Association Studies,Genetic Predisposition to Disease,Genome-Wide Association Study,Glomerular Filtration Rate,Humans,Inheritance Patterns,Kidney Function Tests,Phenotype,Polymorphism, Single Nucleotide,Quantitative Trait Loci,Quantitative Trait, Heritable,Renal Insufficiency, Chronic,Uromodulin","booktitle":"","editor":"","abstract":"Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n\u2009=\u20091,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n\u2009=\u2009416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.","address":"","school":"","issn":"1546-1718","doi":"10.1038\/s41588-019-0407-x","isi":"","pubmed":"31152163","key":"Wuttke2019","howpublished":"","urllink":"","refid":13,"weight":13}
,

{userid:"katrin.horn", "refid":"30","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.","year":"2022","author":"Thomas W Winkler, Humaira Rasheed, Alexander Teumer, Mathias Gorski, Bryce X Rowan, Kira J Stanzick, Laurent F Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y Chu, Bamidele Tayo, Chris H L Thio, Daniele Cusi, Jin-Fang Chai, Karsten B Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, Peter J van der Most, Qiong Yang, Sahar Ghasemi, Teresa Nutile, Yong Li, Giulia Pontali, Felix G\u00fcnther, Abbas Dehghan, Adolfo Correa, Afshin Parsa, Agnese Feresin, Aiko P J de Vries, Alan B Zonderman, Albert V Smith, Albertine J Oldehinkel, Alessandro De Grandi, Alexander R Rosenkranz, Andre Franke, Andrej Teren, Andres Metspalu, Andrew A Hicks, Andrew P Morris, Anke T\u00f6njes, Anna Morgan, Anna I Podgornaia, Annette Peters, Antje K\u00f6rner, Anubha Mahajan, Archie Campbell, Barry I Freedman, Beatrice Spedicati, Belen Ponte, Ben Sch\u00f6ttker, Ben Brumpton, Bernhard Banas, Bernhard K Kr\u00e4mer, Bettina Jung, Bj\u00f8rn Olav \u00c5svold, Blair H Smith, Boting Ning, Brenda W J H Penninx, Brett R Vanderwerff, Bruce M Psaty, Candace M Kammerer, Carl D Langefeld, Caroline Hayward, Cassandra N Spracklen, Cassianne Robinson-Cohen, Catharina A Hartman, Cecilia M Lindgren, Chaolong Wang, Charumathi Sabanayagam, Chew-Kiat Heng, Chiara Lanzani, Chiea-Chuen Khor, Ching-Yu Cheng, Christian Fuchsberger, Christian Gieger, Christian M Shaffer, Christina-Alexandra Schulz, Cristen J Willer, Daniel I Chasman, Daniel F Gudbjartsson, Daniela Ruggiero, Daniela Toniolo, Darina Czamara, David J Porteous, Dawn M Waterworth, Deborah Mascalzoni, Dennis O Mook-Kanamori, Dermot F Reilly, E Warwick Daw, Edith Hofer, Eric Boerwinkle, Erika Salvi, Erwin P Bottinger, E-Shyong Tai, Eulalia Catamo, Federica Rizzi, Feng Guo, Fernando Rivadeneira, Franco Guilianini, Gardar Sveinbjornsson, Georg Ehret, Gerard Waeber, Ginevra Biino, Giorgia Girotto, Giorgio Pistis, Girish N Nadkarni, Graciela E Delgado, Grant W Montgomery, Harold Snieder, Harry Campbell, Harvey D White, He Gao, Heather M Stringham, Helena Schmidt, Hengtong Li, Hermann Brenner, Hilma Holm, Holgen Kirsten, Holly Kramer, Igor Rudan, Ilja M Nolte, Ioanna Tzoulaki, Isleifur Olafsson, Jade Martins, James P Cook, James F Wilson, Jan Halbritter, Janine F Felix, Jasmin Divers, Jaspal S Kooner, Jeannette Jen-Mai Lee, Jeffrey O'Connell, Jerome I Rotter, Jianjun Liu, Jie Xu, Joachim Thiery, Johan \u00c4rnl\u00f6v, Johanna Kuusisto, Johanna Jakobsdottir, Johanne Tremblay, John C Chambers, John B Whitfield, John M Gaziano, Jonathan Marten, Josef Coresh, Jost B Jonas, Josyf C Mychaleckyj, Kaare Christensen, Kai-Uwe Eckardt, Karen L Mohlke, Karlhans Endlich, Katalin Dittrich, Kathleen A Ryan, Kenneth M Rice, Kent D Taylor, Kevin Ho, Kjell Nikus, Koichi Matsuda, Konstantin Strauch, Kozeta Miliku, Kristian Hveem, Lars Lind, Lars Wallentin, Laura M Yerges-Armstrong, Laura M Raffield, Lawrence S Phillips, Lenore J Launer, Leo-Pekka Lyytik\u00e4inen, Leslie A Lange, Lorena Citterio, Lucija Klaric, M Arfan Ikram, Marcus Ising, Marcus E Kleber, Margherita Francescatto, Maria Pina Concas, Marina Ciullo, Mario Piratsu, Marju Orho-Melander, Markku Laakso, Markus Loeffler, Markus Perola, Martin H de Borst, Martin G\u00f6gele, Martina La Bianca, Mary Ann Lukas, Mary F Feitosa, Mary L Biggs, Mary K Wojczynski, Maryam Kavousi, Masahiro Kanai, Masato Akiyama, Masayuki Yasuda, Matthias Nauck, Melanie Waldenberger, Miao-Li Chee, Miao-Ling Chee, Michael Boehnke, Michael H Preuss, Michael Stumvoll, Michael A Province, Michele K Evans, Michelle L O'Donoghue, Michiaki Kubo, Mika K\u00e4h\u00f6nen, Mika Kastarinen, Mike A Nalls, Mikko Kuokkanen, Mohsen Ghanbari, Murielle Bochud, Navya Shilpa Josyula, Nicholas G Martin, Nicholas Y Q Tan, Nicholette D Palmer, Nicola Pirastu, Nicole Schupf, Niek Verweij, Nina Hutri-K\u00e4h\u00f6nen, Nina Mononen, Nisha Bansal, Olivier Devuyst, Olle Melander, Olli T Raitakari, Ozren Polasek, Paolo Manunta, Paolo Gasparini, Pashupati P Mishra, Patrick Sulem, Patrik K E Magnusson, Paul Elliott, Paul M Ridker, Pavel Hamet, Per O Svensson, Peter K Joshi, Peter Kovacs, Peter P Pramstaller, Peter Rossing, Peter Vollenweider, Pim van der Harst, Rajkumar Dorajoo, Ralene Z H Sim, Ralph Burkhardt, Ran Tao, Raymond Noordam, Reedik M\u00e4gi, Reinhold Schmidt, Ren\u00e9e de Mutsert, Rico Rueedi, Rob M van Dam, Robert J Carroll, Ron T Gansevoort, Ruth J F Loos, Sala Cinzia Felicita, Sanaz Sedaghat, Sandosh Padmanabhan, Sandra Freitag-Wolf, Sarah A Pendergrass, Sarah E Graham, Scott D Gordon, Shih-Jen Hwang, Shona M Kerr, Simona Vaccargiu, Snehal B Patil, Stein Hallan, Stephan J L Bakker, Su-Chi Lim, Susanne Lucae, Suzanne Vogelezang, Sven Bergmann, Tanguy Corre, Tarunveer S Ahluwalia, Terho Lehtim\u00e4ki, Thibaud S Boutin, Thomas Meitinger, Tien-Yin Wong, Tobias Bergler, Ton J Rabelink, T\u00f5nu Esko, Toomas Haller, Unnur Thorsteinsdottir, Uwe V\u00f6lker, Valencia Hui Xian Foo, Veikko Salomaa, Veronique Vitart, Vilmantas Giedraitis, Vilmundur Gudnason, Vincent W V Jaddoe, Wei Huang, Weihua Zhang, Wen Bin Wei, Wieland Kiess, Winfried M\u00e4rz, Wolfgang Koenig, Wolfgang Lieb, Xin Gao, Xueling Sim, Ya Xing Wang, Yechiel Friedlander, Yih-Chung Tham, Yoichiro Kamatani, Yukinori Okada, Yuri Milaneschi, Zhi Yu,  ,  ,  , Klaus J Stark, Kari Stefansson, Carsten A B\u00f6ger, Adriana M Hung, Florian Kronenberg, Anna K\u00f6ttgen, Cristian Pattaro, Iris M Heid","journal":"Communications biology","volume":"5","number":"1","pages":"","month":"Jun","doi":"10.1002\/(SICI)1098-1004(200001)15:1<57::AID-HUMU12>3.0.CO;2-G","pubmed":"35697829","pdflink":"","urllink":"","abstract":"Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n\u2009=\u2009178,691, n\u2009=\u20091,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM\/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.","note":"","tags":"Creatinine,Diabetes Mellitus,Diabetic Nephropathies,Genome-Wide Association Study,Glomerular Filtration Rate,Humans,Kidney","weight":30,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"2399-3642","isi":"","key":"Winkler2022","howpublished":""}
,

{userid:"katrin.horn", "refid":"33","repocollections":"","attachment":"","_thumb":"","articletype":"article","sectionheading":"","title":"A saturated map of common genetic variants associated with human height.","year":"2022","author":"Lo\u00efc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Saori Sakaue, Marielisa Graff, Anders U Eliasen, Yunxuan Jiang, Sridharan Raghavan, Jenkai Miao, Joshua D Arias, Sarah E Graham, Ronen E Mukamel, Cassandra N Spracklen, Xianyong Yin, Shyh-Huei Chen, Teresa Ferreira, Heather H Highland, Yingjie Ji, Tugce Karaderi, Kuang Lin, Kreete L\u00fcll, Deborah E Malden, Carolina Medina-Gomez, Moara Machado, Amy Moore, Sina R\u00fceger, Xueling Sim, Scott Vrieze, Tarunveer S Ahluwalia, Masato Akiyama, Matthew A Allison, Marcus Alvarez, Mette K Andersen, Alireza Ani, Vivek Appadurai, Liubov Arbeeva, Seema Bhaskar, Lawrence F Bielak, Sailalitha Bollepalli, Lori L Bonnycastle, Jette Bork-Jensen, Jonathan P Bradfield, Yuki Bradford, Peter S Braund, Jennifer A Brody, Kristoffer S Burgdorf, Brian E Cade, Hui Cai, Qiuyin Cai, Archie Campbell, Marisa Ca\u00f1adas-Garre, Eulalia Catamo, Jin-Fang Chai, Xiaoran Chai, Li-Ching Chang, Yi-Cheng Chang, Chien-Hsiun Chen, Alessandra Chesi, Seung Hoan Choi, Ren-Hua Chung, Massimiliano Cocca, Maria Pina Concas, Christian Couture, Gabriel Cuellar-Partida, Rebecca Danning, E Warwick Daw, Frauke Degenhard, Graciela E Delgado, Alessandro Delitala, Ayse Demirkan, Xuan Deng, Poornima Devineni, Alexander Dietl, Maria Dimitriou, Latchezar Dimitrov, Rajkumar Dorajoo, Arif B Ekici, Jorgen E Engmann, Zammy Fairhurst-Hunter, Aliki-Eleni Farmaki, Jessica D Faul, Juan-Carlos Fernandez-Lopez, Lukas Forer, Margherita Francescatto, Sandra Freitag-Wolf, Christian Fuchsberger, Tessel E Galesloot, Yan Gao, Zishan Gao, Frank Geller, Olga Giannakopoulou, Franco Giulianini, Anette P Gjesing, Anuj Goel, Scott D Gordon, Mathias Gorski, Jakob Grove, Xiuqing Guo, Stefan Gustafsson, Jeffrey Haessler, Thomas F Hansen, Aki S Havulinna, Simon J Haworth, Jing He, Nancy Heard-Costa, Prashantha Hebbar, George Hindy, Yuk-Lam A Ho, Edith Hofer, Elizabeth Holliday, Katrin Horn, Whitney E Hornsby, Jouke-Jan Hottenga, Hongyan Huang, Jie Huang, Alicia Huerta-Chagoya, Jennifer E Huffman, Yi-Jen Hung, Shaofeng Huo, Mi Yeong Hwang, Hiroyuki Iha, Daisuke D Ikeda, Masato Isono, Anne U Jackson, Susanne J\u00e4ger, Iris E Jansen, Ingegerd Johansson, Jost B Jonas, Anna Jonsson, Torben J\u00f8rgensen, Ioanna-Panagiota Kalafati, Masahiro Kanai, Stavroula Kanoni, Line L K\u00e5rhus, Anuradhani Kasturiratne, Tomohiro Katsuya, Takahisa Kawaguchi, Rachel L Kember, Katherine A Kentistou, Han-Na Kim, Young Jin Kim, Marcus E Kleber, Maria J Knol, Azra Kurbasic, Marie Lauzon, Phuong Le, Rodney Lea, Jong-Young Lee, Hampton L Leonard, Shengchao A Li, Xiaohui Li, Xiaoyin Li, Jingjing Liang, Honghuang Lin, Shih-Yi Lin, Jun Liu, Xueping Liu, Ken Sin Lo, Jirong Long, Laura Lores-Motta, Jian'an Luan, Valeriya Lyssenko, Leo-Pekka Lyytik\u00e4inen, Anubha Mahajan, Vasiliki Mamakou, Massimo Mangino, Ani Manichaikul, Jonathan Marten, Manuel Mattheisen, Laven Mavarani, Aaron F McDaid, Karina Meidtner, Tori L Melendez, Josep M Mercader, Yuri Milaneschi, Jason E Miller, Iona Y Millwood, Pashupati P Mishra, Ruth E Mitchell, Line T M\u00f8llehave, Anna Morgan, Soeren Mucha, Matthias Munz, Masahiro Nakatochi, Christopher P Nelson, Maria Nethander, Chu Won Nho, Aneta A Nielsen, Ilja M Nolte, Suraj S Nongmaithem, Raymond Noordam, Ioanna Ntalla, Teresa Nutile, Anita Pandit, Paraskevi Christofidou, Katri P\u00e4rna, Marc Pauper, Eva R B Petersen, Liselotte V Petersen, Niina Pitk\u00e4nen, Ozren Pola\u0161ek, Alaitz Poveda, Michael H Preuss, Saiju Pyarajan, Laura M Raffield, Hiromi Rakugi, Julia Ramirez, Asif Rasheed, Dennis Raven, Nigel W Rayner, Carlos Riveros, Rebecca Rohde, Daniela Ruggiero, Sanni E Ruotsalainen, Kathleen A Ryan, Maria Sabater-Lleal, Richa Saxena, Markus Scholz, Anoop Sendamarai, Botong Shen, Jingchunzi Shi, Jae Hun Shin, Carlo Sidore, Colleen M Sitlani, Roderick C Slieker, Roelof A J Smit, Albert V Smith, Jennifer A Smith, Laura J Smyth, Lorraine Southam, Valgerdur Steinthorsdottir, Liang Sun, Fumihiko Takeuchi, Divya Sri Priyanka Tallapragada, Kent D Taylor, Bamidele O Tayo, Catherine Tcheandjieu, Natalie Terzikhan, Paola Tesolin, Alexander Teumer, Elizabeth Theusch, Deborah J Thompson, Gudmar Thorleifsson, Paul R H J Timmers, Stella Trompet, Constance Turman, Simona Vaccargiu, Sander W van der Laan, Peter J van der Most, Jan B van Klinken, Jessica van Setten, Shefali S Verma, Niek Verweij, Yogasudha Veturi, Carol A Wang, Chaolong Wang, Lihua Wang, Zhe Wang, Helen R Warren, Wen Bin Wei, Ananda R Wickremasinghe, Matthias Wielscher, Kerri L Wiggins, Bendik S Winsvold, Andrew Wong, Yang Wu, Matthias Wuttke, Rui Xia, Tian Xie, Ken Yamamoto, Jingyun Yang, Jie Yao, Hannah Young, Noha A Yousri, Lei Yu, Lingyao Zeng, Weihua Zhang, Xinyuan Zhang, Jing-Hua Zhao, Wei Zhao, Wei Zhou, Martina E Zimmermann, Magdalena Zoledziewska, Linda S Adair, Hieab H H Adams, Carlos A Aguilar-Salinas, Fahd Al-Mulla, Donna K Arnett, Folkert W Asselbergs, Bj\u00f8rn Olav \u00c5svold, John Attia, Bernhard Banas, Stefania Bandinelli, David A Bennett, Tobias Bergler, Dwaipayan Bharadwaj, Ginevra Biino, Hans Bisgaard, Eric Boerwinkle, Carsten A B\u00f6ger, Klaus B\u00f8nnelykke, Dorret I Boomsma, Anders D B\u00f8rglum, Judith B Borja, Claude Bouchard, Donald W Bowden, Ivan Brandslund, Ben Brumpton, Julie E Buring, Mark J Caulfield, John C Chambers, Giriraj R Chandak, Stephen J Chanock, Nish Chaturvedi, Yii-Der Ida Chen, Zhengming Chen, Ching-Yu Cheng, Ingrid E Christophersen, Marina Ciullo, John W Cole, Francis S Collins, Richard S Cooper, Miguel Cruz, Francesco Cucca, L Adrienne Cupples, Michael J Cutler, Scott M Damrauer, Thomas M Dantoft, Gert J de Borst, Lisette C P G M de Groot, Philip L De Jager, Dominique P V de Kleijn, H Janaka de Silva, George V Dedoussis, Anneke I den Hollander, Shufa Du, Douglas F Easton, Petra J M Elders, A Heather Eliassen, Patrick T Ellinor, S\u00f6lve Elmst\u00e5hl, Jeanette Erdmann, Michele K Evans, Diane Fatkin, Bjarke Feenstra, Mary F Feitosa, Luigi Ferrucci, Ian Ford, Myriam Fornage, Andre Franke, Paul W Franks, Barry I Freedman, Paolo Gasparini, Christian Gieger, Giorgia Girotto, Michael E Goddard, Yvonne M Golightly, Clicerio Gonzalez-Villalpando, Penny Gordon-Larsen, Harald Grallert, Struan F A Grant, Niels Grarup, Lyn Griffiths, Vilmundur Gudnason, Christopher Haiman, Hakon Hakonarson, Torben Hansen, Catharina A Hartman, Andrew T Hattersley, Caroline Hayward, Susan R Heckbert, Chew-Kiat Heng, Christian Hengstenberg, Alex W Hewitt, Haretsugu Hishigaki, Carel B Hoyng, Paul L Huang, Wei Huang, Steven C Hunt, Kristian Hveem, Elina Hypp\u00f6nen, William G Iacono, Sahoko Ichihara, M Arfan Ikram, Carmen R Isasi, Rebecca D Jackson, Marjo-Riitta Jarvelin, Zi-Bing Jin, Karl-Heinz J\u00f6ckel, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Mika K\u00e4h\u00f6nen, Yoichiro Kamatani, Kui Dong Kang, Jaakko Kaprio, Sharon L R Kardia, Fredrik Karpe, Norihiro Kato, Frank Kee, Thorsten Kessler, Amit V Khera, Chiea Chuen Khor, Lambertus A L M Kiemeney, Bong-Jo Kim, Eung Kweon Kim, Hyung-Lae Kim, Paulus Kirchhof, Mika Kivimaki, Woon-Puay Koh, Heikki A Koistinen, Genovefa D Kolovou, Jaspal S Kooner, Charles Kooperberg, Anna K\u00f6ttgen, Peter Kovacs, Adriaan Kraaijeveld, Peter Kraft, Ronald M Krauss, Meena Kumari, Zoltan Kutalik, Markku Laakso, Leslie A Lange, Claudia Langenberg, Lenore J Launer, Loic Le Marchand, Hyejin Lee, Nanette R Lee, Terho Lehtim\u00e4ki, Huaixing Li, Liming Li, Wolfgang Lieb, Xu Lin, Lars Lind, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Markus Loeffler, Barry London, Steven A Lubitz, Stephen J Lye, David A Mackey, Reedik M\u00e4gi, Patrik K E Magnusson, Gregory M Marcus, Pedro Marques Vidal, Nicholas G Martin, Winfried M\u00e4rz, Fumihiko Matsuda, Robert W McGarrah, Matt McGue, Amy Jayne McKnight, Sarah E Medland, Dan Mellstr\u00f6m, Andres Metspalu, Braxton D Mitchell, Paul Mitchell, Dennis O Mook-Kanamori, Andrew D Morris, Lorelei A Mucci, Patricia B Munroe, Mike A Nalls, Saman Nazarian, Amanda E Nelson, Matt J Neville, Christopher Newton-Cheh, Christopher S Nielsen, Markus M N\u00f6then, Claes Ohlsson, Albertine J Oldehinkel, Lorena Orozco, Katja Pahkala, P\u00e4ivi Pajukanta, Colin N A Palmer, Esteban J Parra, Cristian Pattaro, Oluf Pedersen, Craig E Pennell, Brenda W J H Penninx, Louis Perusse, Annette Peters, Patricia A Peyser, David J Porteous, Danielle Posthuma, Chris Power, Peter P Pramstaller, Michael A Province, Qibin Qi, Jia Qu, Daniel J Rader, Olli T Raitakari, Sarju Ralhan, Loukianos S Rallidis, Dabeeru C Rao, Susan Redline, Dermot F Reilly, Alexander P Reiner, Sang Youl Rhee, Paul M Ridker, Michiel Rienstra, Samuli Ripatti, Marylyn D Ritchie, Dan M Roden, Frits R Rosendaal, Jerome I Rotter, Igor Rudan, Femke Rutters, Charumathi Sabanayagam, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Dharambir K Sanghera, Naveed Sattar, B\u00f6rge Schmidt, Helena Schmidt, Reinhold Schmidt, Matthias B Schulze, Heribert Schunkert, Laura J Scott, Rodney J Scott, Peter Sever, Eric J Shiroma, M Benjamin Shoemaker, Xiao-Ou Shu, Eleanor M Simonsick, Mario Sims, Jai Rup Singh, Andrew B Singleton, Moritz F Sinner, J Gustav Smith, Harold Snieder, Tim D Spector, Meir J Stampfer, Klaus J Stark, David P Strachan, Leen M 't Hart, Yasuharu Tabara, Hua Tang, Jean-Claude Tardif, Thangavel A Thanaraj, Nicholas J Timpson, Anke T\u00f6njes, Angelo Tremblay, Tiinamaija Tuomi, Jaakko Tuomilehto, Maria-Teresa Tusi\u00e9-Luna, Andre G Uitterlinden, Rob M van Dam, Pim van der Harst, Nathalie Van der Velde, Cornelia M van Duijn, Natasja M van Schoor, Veronique Vitart, Uwe V\u00f6lker, Peter Vollenweider, Henry V\u00f6lzke, Niels H Wacher-Rodarte, Mark Walker, Ya Xing Wang, Nicholas J Wareham, Richard M Watanabe, Hugh Watkins, David R Weir, Thomas M Werge, Elisabeth Widen, Lynne R Wilkens, Gonneke Willemsen, Walter C Willett, James F Wilson, Tien-Yin Wong, Jeong-Taek Woo, Alan F Wright, Jer-Yuarn Wu, Huichun Xu, Chittaranjan S Yajnik, Mitsuhiro Yokota, Jian-Min Yuan, Eleftheria Zeggini, Babette S Zemel, Wei Zheng, Xiaofeng Zhu, Joseph M Zmuda, Alan B Zonderman, John-Anker Zwart,  ,  ,  ,  ,  ,  ,  , Daniel I Chasman, Yoon Shin Cho, Iris M Heid, Mark I McCarthy, Maggie C Y Ng, Christopher J O'Donnell, Fernando Rivadeneira, Unnur Thorsteinsdottir, Yan V Sun, E Shyong Tai, Michael Boehnke, Panos Deloukas, Anne E Justice, Cecilia M Lindgren, Ruth J F Loos, Karen L Mohlke, Kari E North, Kari Stefansson, Robin G Walters, Thomas W Winkler, Kristin L Young, Po-Ru Loh, Jian Yang, T\u00f5nu Esko, Themistocles L Assimes, Adam Auton, Goncalo R Abecasis, Cristen J Willer, Adam E Locke, Sonja I Berndt, Guillaume Lettre, Timothy M Frayling, Yukinori Okada, Andrew R Wood, Peter M Visscher, Joel N Hirschhorn","journal":"Nature","volume":"610","number":"7933","pages":"704-712","month":"Oct","doi":"10.1038\/s41467-018-03371-0","pubmed":"36224396","pdflink":"","urllink":"","abstract":"Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4\u2009million individuals of diverse ancestries, we show\u00a0that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90\u2009kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.","note":"","tags":"Humans,Genome-Wide Association Study,Linkage Disequilibrium,Polymorphism, Single Nucleotide,Gene Frequency,Genome","weight":33,"publisher":"","booktitle":"","editor":"","address":"","school":"","issn":"1476-4687","isi":"","key":"Yengo2022","howpublished":""}
  ]
}

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